IMP: Integrative Multi-species Prediction

Mus musculus

110 known processes

Ep300

E1A binding protein p300

(Aliases: A730011L11,KAT3B,A430090G16,p300)

Ensembl: ENSMUSG00000055024
Entrez: 328572
UniProtKB: Q8BJ14
UniProtKB: B2RWS6

Process Predictions
Disease Predictions

Ep300 biological process predictions

Show only novel predictionsHighlight processes of functional analogs

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Biological process	GO term ID	Process size	Probability	Func Analog Org
chromatin modification	GO:0016568	187	0.970	Human Mouse Worm
protein acylation	GO:0043543	64	0.969	Human Mouse Worm
covalent chromatin modification	GO:0016569	163	0.964	Human Mouse Worm
histone acetylation	GO:0016573	41	0.963	Human Mouse Worm
chromatin organization	GO:0006325	206	0.952	Human Mouse Worm
peptidyl lysine modification	GO:0018205	77	0.944	Human Mouse Worm
dna metabolic process	GO:0006259	303	0.899
internal protein amino acid acetylation	GO:0006475	42	0.881	Human Mouse Worm
peptidyl lysine acetylation	GO:0018394	45	0.824	Human Mouse Worm
histone modification	GO:0016570	159	0.753	Human Mouse Worm
cellular response to dna damage stimulus	GO:0006974	207	0.745	Human
cellular amino acid metabolic process	GO:0006520	103	0.707
regulation of cellular amine metabolic process	GO:0033238	20	0.706
histone h4 acetylation	GO:0043967	10	0.688	Human
regulation of cellular ketone metabolic process	GO:0010565	66	0.681
gene silencing	GO:0016458	38	0.669
myeloid cell differentiation	GO:0030099	233	0.669
cellular response to radiation	GO:0071478	28	0.657
histone h3 acetylation	GO:0043966	14	0.651
methylation	GO:0032259	134	0.650
amine metabolic process	GO:0009308	45	0.630
regulation of histone modification	GO:0031056	56	0.616
internal peptidyl lysine acetylation	GO:0018393	42	0.603	Human Mouse Worm
positive regulation of cellular amine metabolic process	GO:0033240	5	0.562
response to uv	GO:0009411	44	0.550
protein methylation	GO:0006479	81	0.543
cellular ketone metabolic process	GO:0042180	84	0.536
regulation of response to drug	GO:2001023	2	0.536
embryonic placenta development	GO:0001892	98	0.529
male gamete generation	GO:0048232	285	0.523	Worm
positive regulation of apoptotic process	GO:0043065	217	0.501
cellular response to light stimulus	GO:0071482	19	0.500
negative regulation of cell proliferation	GO:0008285	296	0.500
positive regulation of cell death	GO:0010942	224	0.499
response to oxidative stress	GO:0006979	123	0.497
cellular response to external stimulus	GO:0071496	88	0.494
placenta development	GO:0001890	140	0.488
lipid phosphorylation	GO:0046834	25	0.462
phosphatidylinositol phosphorylation	GO:0046854	23	0.439
peptidyl amino acid modification	GO:0018193	336	0.429	Human Mouse Worm
regulation of chromatin modification	GO:1903308	57	0.412
regulation of histone methylation	GO:0031060	30	0.405
response to radiation	GO:0009314	165	0.404
erythrocyte differentiation	GO:0030218	88	0.394
gland development	GO:0048732	330	0.394
oxidation reduction process	GO:0055114	342	0.382
regulation of chromatin silencing	GO:0031935	2	0.380
cellular carbohydrate metabolic process	GO:0044262	119	0.373
cellular lipid metabolic process	GO:0044255	323	0.365
homeostasis of number of cells	GO:0048872	210	0.365
hexose metabolic process	GO:0019318	98	0.355
positive regulation of programmed cell death	GO:0043068	218	0.354
generation of precursor metabolites and energy	GO:0006091	103	0.351
negative regulation of cellular amino acid metabolic process	GO:0045763	0	0.345
response to inorganic substance	GO:0010035	96	0.335
response to decreased oxygen levels	GO:0036293	59	0.334	Human
signal transduction by p53 class mediator	GO:0072331	51	0.325	Human
negative regulation of gene expression epigenetic	GO:0045814	15	0.316
spermatogenesis	GO:0007283	284	0.316	Worm
protein alkylation	GO:0008213	81	0.307
response to acid chemical	GO:0001101	111	0.298
carbohydrate metabolic process	GO:0005975	230	0.294
regulation of organelle organization	GO:0033043	289	0.291
leukocyte differentiation	GO:0002521	342	0.290
regulation of cellular amino acid metabolic process	GO:0006521	5	0.288
genetic imprinting	GO:0071514	27	0.288
lipid biosynthetic process	GO:0008610	179	0.283
cellular response to oxidative stress	GO:0034599	76	0.283
response to testosterone	GO:0033574	3	0.278
negative regulation of cell cycle	GO:0045786	123	0.271
negative regulation of cell size	GO:0045792	3	0.270
macromolecule methylation	GO:0043414	120	0.267
myeloid leukocyte differentiation	GO:0002573	119	0.265
monosaccharide metabolic process	GO:0005996	106	0.262
regulation of chromatin organization	GO:1902275	57	0.259
positive regulation of organelle organization	GO:0010638	128	0.254
limb morphogenesis	GO:0035108	149	0.254
muscle cell differentiation	GO:0042692	261	0.252
cellular amine metabolic process	GO:0044106	44	0.248
phosphatidylinositol 3 phosphate biosynthetic process	GO:0036092	6	0.246
maintenance of chromatin silencing	GO:0006344	2	0.244
chromatin silencing	GO:0006342	15	0.238
t cell differentiation	GO:0030217	174	0.237
regulation of genetic imprinting	GO:2000653	5	0.225
positive regulation of cellular amino acid metabolic process	GO:0045764	3	0.219
glucose metabolic process	GO:0006006	92	0.213
negative regulation of cellular amine metabolic process	GO:0033239	1	0.212
positive regulation of histone h3 k9 methylation	GO:0051574	4	0.212
response to light stimulus	GO:0009416	135	0.209
negative regulation of chromatin silencing	GO:0031936	1	0.209
regulation of glucose metabolic process	GO:0010906	60	0.209
response to reactive oxygen species	GO:0000302	56	0.205
dna repair	GO:0006281	107	0.205
histone lysine methylation	GO:0034968	50	0.203
respiratory tube development	GO:0030323	167	0.203
regulation of cellular carbohydrate metabolic process	GO:0010675	75	0.200
embryonic organ morphogenesis	GO:0048562	276	0.198
regulation of chromosome organization	GO:0033044	83	0.196
macromolecule catabolic process	GO:0009057	281	0.193
regulation of cell size	GO:0008361	72	0.189
regulation of feeding behavior	GO:0060259	3	0.189
germ cell development	GO:0007281	185	0.187	Worm
histone methylation	GO:0016571	71	0.185
appendage development	GO:0048736	166	0.184
dendrite development	GO:0016358	115	0.179
dna methylation	GO:0006306	43	0.179
cell type specific apoptotic process	GO:0097285	268	0.178
cellular response to abiotic stimulus	GO:0071214	56	0.178
neural tube development	GO:0021915	160	0.176
morphogenesis of embryonic epithelium	GO:0016331	159	0.172
positive regulation of chromatin modification	GO:1903310	28	0.170
transmembrane receptor protein tyrosine kinase signaling pathway	GO:0007169	247	0.168
developmental maturation	GO:0021700	193	0.167
regulation of cellular response to drug	GO:2001038	1	0.164
response to drug	GO:0042493	75	0.162
regulation of hydrolase activity	GO:0051336	246	0.161
regionalization	GO:0003002	337	0.159
regulation of insulin receptor signaling pathway	GO:0046626	21	0.154
response to peptide	GO:1901652	136	0.153
multicellular organism growth	GO:0035264	161	0.152
cellular response to nitric oxide	GO:0071732	4	0.152
camera type eye development	GO:0043010	266	0.151
regulation of cell cycle	GO:0051726	281	0.149
regulation of cellular catabolic process	GO:0031329	242	0.148
protein maturation	GO:0051604	176	0.146
morphogenesis of a branching structure	GO:0001763	203	0.146
response to oxygen levels	GO:0070482	62	0.144	Human
cellular response to gamma radiation	GO:0071480	4	0.140
regulation of cellular component size	GO:0032535	121	0.138
insulin receptor signaling pathway	GO:0008286	49	0.137
neural tube formation	GO:0001841	108	0.137
negative regulation of myeloid cell differentiation	GO:0045638	38	0.136
cellular response to acid chemical	GO:0071229	68	0.136
limb development	GO:0060173	166	0.136
positive regulation of insulin receptor signaling pathway	GO:0046628	4	0.134
embryonic limb morphogenesis	GO:0030326	126	0.133
regulation of establishment of protein localization	GO:0070201	181	0.131
chromatin remodeling	GO:0006338	32	0.129
response to metal ion	GO:0010038	47	0.129
regulation of wnt signaling pathway	GO:0030111	123	0.128
negative regulation of leukocyte differentiation	GO:1902106	51	0.127
telencephalon development	GO:0021537	186	0.126
skeletal muscle organ development	GO:0060538	163	0.126
maintenance of location	GO:0051235	89	0.126	Worm
intracellular steroid hormone receptor signaling pathway	GO:0030518	29	0.125	Human
embryonic appendage morphogenesis	GO:0035113	126	0.125
positive regulation of transcription from rna polymerase ii promoter in response to stress	GO:0036003	3	0.125
lymphocyte differentiation	GO:0030098	242	0.125
regulation of proteolysis	GO:0030162	164	0.124
lung development	GO:0030324	164	0.123
cellular response to insulin stimulus	GO:0032869	78	0.123
response to organonitrogen compound	GO:0010243	246	0.121
intracellular receptor signaling pathway	GO:0030522	74	0.121	Human
intrinsic apoptotic signaling pathway in response to oxidative stress	GO:0008631	19	0.120
dna damage response signal transduction by p53 class mediator	GO:0030330	19	0.120
morphogenesis of a branching epithelium	GO:0061138	193	0.119
organophosphate biosynthetic process	GO:0090407	122	0.118
embryonic epithelial tube formation	GO:0001838	130	0.118
development of primary female sexual characteristics	GO:0046545	73	0.118
phosphatidylinositol biosynthetic process	GO:0006661	15	0.116
glycerophospholipid metabolic process	GO:0006650	71	0.115
negative regulation of cellular protein metabolic process	GO:0032269	247	0.114
response to steroid hormone	GO:0048545	56	0.114	Human
chromatin mediated maintenance of transcription	GO:0048096	2	0.111
mammary gland epithelium development	GO:0061180	65	0.111
epithelial cell development	GO:0002064	159	0.111
energy derivation by oxidation of organic compounds	GO:0015980	77	0.110
nucleoside phosphate metabolic process	GO:0006753	338	0.110
fibroblast proliferation	GO:0048144	35	0.108
regulation of fat cell differentiation	GO:0045598	81	0.107
cellular response to organonitrogen compound	GO:0071417	145	0.107
nucleotide metabolic process	GO:0009117	332	0.107
organonitrogen compound biosynthetic process	GO:1901566	192	0.107
negative regulation of phosphorylation	GO:0042326	166	0.107
intrinsic apoptotic signaling pathway	GO:0097193	132	0.106	Human
cellular response to hormone stimulus	GO:0032870	150	0.105
cellular protein catabolic process	GO:0044257	155	0.103
neuron apoptotic process	GO:0051402	142	0.103
muscle cell apoptotic process	GO:0010657	18	0.103
response to extracellular stimulus	GO:0009991	127	0.103
wnt signaling pathway	GO:0016055	188	0.103
regulation of muscle cell apoptotic process	GO:0010660	17	0.102
myotube differentiation	GO:0014902	105	0.102
apoptotic signaling pathway	GO:0097190	306	0.101	Human
positive regulation of protein phosphorylation	GO:0001934	242	0.100
carbohydrate homeostasis	GO:0033500	128	0.100
digestive tract development	GO:0048565	190	0.100
cellular response to nutrient levels	GO:0031669	64	0.100
neuron death	GO:0070997	154	0.099
double strand break repair	GO:0006302	48	0.098
response to insulin	GO:0032868	100	0.097
positive regulation of myeloid cell differentiation	GO:0045639	43	0.097
positive regulation of chromosome organization	GO:2001252	33	0.096
branching morphogenesis of an epithelial tube	GO:0048754	159	0.096
stem cell development	GO:0048864	219	0.096	Mouse
sensory organ morphogenesis	GO:0090596	242	0.095
female sex differentiation	GO:0046660	84	0.095
negative regulation of cell aging	GO:0090344	5	0.095
apoptotic mitochondrial changes	GO:0008637	48	0.095
negative regulation of cell growth	GO:0030308	44	0.094
extrinsic apoptotic signaling pathway	GO:0097191	126	0.094
purine ribonucleotide metabolic process	GO:0009150	290	0.094
carbon catabolite activation of transcription	GO:0045991	4	0.092
glycerophospholipid biosynthetic process	GO:0046474	32	0.091
spermatid differentiation	GO:0048515	115	0.091
posttranscriptional regulation of gene expression	GO:0010608	155	0.090
regulation of mitotic cell cycle	GO:0007346	126	0.089
negative regulation of sequence specific dna binding transcription factor activity	GO:0043433	40	0.089
positive regulation of cellular catabolic process	GO:0031331	148	0.088
tube formation	GO:0035148	140	0.088
regulation of neuron death	GO:1901214	134	0.088
positive regulation of cytokine production	GO:0001819	174	0.087
negative regulation of fat cell differentiation	GO:0045599	36	0.087
cell maturation	GO:0048469	127	0.087
cellular response to drug	GO:0035690	15	0.086
protein localization to nucleus	GO:0034504	121	0.086
heart contraction	GO:0060047	93	0.086
positive regulation of transcription by galactose	GO:0000411	1	0.086
heterocycle catabolic process	GO:0046700	280	0.086
regulation of response to oxidative stress	GO:1902882	19	0.085
intrinsic apoptotic signaling pathway in response to dna damage	GO:0008630	57	0.085	Human
extrinsic apoptotic signaling pathway via death domain receptors	GO:0008625	34	0.083
negative regulation of oxidative stress induced intrinsic apoptotic signaling pathway	GO:1902176	4	0.082
angiogenesis	GO:0001525	201	0.082
negative regulation of phosphorus metabolic process	GO:0010563	184	0.082
protein oligomerization	GO:0051259	67	0.082
positive regulation of apoptotic signaling pathway	GO:2001235	95	0.082
female gamete generation	GO:0007292	74	0.082	Worm
negative regulation of growth	GO:0045926	99	0.082
development of primary sexual characteristics	GO:0045137	143	0.082
skeletal system morphogenesis	GO:0048705	203	0.082
chromatin silencing at rdna	GO:0000183	3	0.081
columnar cuboidal epithelial cell differentiation	GO:0002065	82	0.081
protein ubiquitination	GO:0016567	171	0.080
skeletal system development	GO:0001501	356	0.079
regulation of cellular response to oxidative stress	GO:1900407	19	0.079
nucleocytoplasmic transport	GO:0006913	139	0.079
protein catabolic process	GO:0030163	221	0.079
mammary gland morphogenesis	GO:0060443	54	0.079
regulation of autophagy	GO:0010506	30	0.079
regulation of binding	GO:0051098	111	0.078
carbohydrate derivative biosynthetic process	GO:1901137	183	0.078
positive regulation of dna templated transcription elongation	GO:0032786	2	0.077
negative regulation of dna replication	GO:0008156	4	0.076
cellular macromolecule catabolic process	GO:0044265	206	0.076
transmembrane receptor protein serine threonine kinase signaling pathway	GO:0007178	194	0.076
release of cytochrome c from mitochondria	GO:0001836	23	0.076
regulation of cytoplasmic transport	GO:1903649	112	0.076
regulation of transcription from rna polymerase ii promoter by galactose	GO:0000431	1	0.075
response to molecule of bacterial origin	GO:0002237	143	0.075
positive regulation of protein modification process	GO:0031401	299	0.074
labyrinthine layer development	GO:0060711	49	0.074
epithelial cell proliferation	GO:0050673	174	0.074
neuron maturation	GO:0042551	29	0.073
cellular response to oxygen levels	GO:0071453	20	0.073
positive regulation of cysteine type endopeptidase activity	GO:2001056	39	0.072
muscle cell development	GO:0055001	133	0.072
i kappab kinase nf kappab signaling	GO:0007249	85	0.072
regulation of peptidase activity	GO:0052547	96	0.072
cellular response to peptide hormone stimulus	GO:0071375	92	0.071
regulation of endopeptidase activity	GO:0052548	89	0.070
regulation of peptidyl lysine acetylation	GO:2000756	22	0.070
cell cycle checkpoint	GO:0000075	47	0.070
regulation of leukocyte differentiation	GO:1902105	159	0.069
neural precursor cell proliferation	GO:0061351	121	0.069
regulation of protein stability	GO:0031647	52	0.069
purine ribonucleotide catabolic process	GO:0009154	208	0.069
negative regulation of cellular senescence	GO:2000773	3	0.069
purine ribonucleoside catabolic process	GO:0046130	205	0.069
protein processing	GO:0016485	163	0.069
protein import	GO:0017038	101	0.068
gastrulation	GO:0007369	116	0.068
regulation of lipid metabolic process	GO:0019216	118	0.068
response to alcohol	GO:0097305	48	0.067
modification dependent macromolecule catabolic process	GO:0043632	133	0.067
response to hypoxia	GO:0001666	58	0.067	Human
hematopoietic progenitor cell differentiation	GO:0002244	143	0.067
negative regulation of molecular function	GO:0044092	258	0.067
monocarboxylic acid metabolic process	GO:0032787	191	0.066
embryonic hemopoiesis	GO:0035162	23	0.066
regulation of anatomical structure size	GO:0090066	178	0.066
cellular response to peptide	GO:1901653	92	0.066
digestive tract morphogenesis	GO:0048546	147	0.066
negative regulation of neuron death	GO:1901215	98	0.065
cellular response to lipid	GO:0071396	145	0.065
positive regulation of macroautophagy	GO:0016239	3	0.065
carbon catabolite activation of transcription from rna polymerase ii promoter	GO:0000436	4	0.065
positive regulation of neuron apoptotic process	GO:0043525	25	0.064
regulation of mitotic cell cycle phase transition	GO:1901990	73	0.064
protein localization to organelle	GO:0033365	185	0.063
negative regulation of transforming growth factor beta receptor signaling pathway	GO:0030512	26	0.063
response to purine containing compound	GO:0014074	28	0.063
response to nutrient levels	GO:0031667	109	0.062
fat cell differentiation	GO:0045444	160	0.062
stem cell differentiation	GO:0048863	268	0.062	Mouse
response to heat	GO:0009408	27	0.062
negative regulation of phosphate metabolic process	GO:0045936	184	0.062
blastocyst development	GO:0001824	80	0.061
regulation of myeloid leukocyte differentiation	GO:0002761	58	0.061
regulation of cellular ketone metabolic process by regulation of transcription from rna polymerase ii promoter	GO:0072364	7	0.061
response to peptide hormone	GO:0043434	127	0.061
reactive oxygen species metabolic process	GO:0072593	84	0.061
regulation of dna templated transcription in response to stress	GO:0043620	9	0.061
appendage morphogenesis	GO:0035107	149	0.061
muscle fiber development	GO:0048747	76	0.061
glycerolipid metabolic process	GO:0046486	122	0.060
regulation of zinc ion transport	GO:0071579	2	0.060
neural tube closure	GO:0001843	90	0.060
primary neural tube formation	GO:0014020	95	0.059
organic hydroxy compound metabolic process	GO:1901615	203	0.059
regulation of apoptotic signaling pathway	GO:2001233	197	0.059
actin cytoskeleton organization	GO:0030036	220	0.059
organic cyclic compound catabolic process	GO:1901361	295	0.058
purine nucleoside monophosphate metabolic process	GO:0009126	81	0.058
positive regulation of endopeptidase activity	GO:0010950	43	0.058
regulation of carbohydrate metabolic process	GO:0006109	75	0.058
t cell activation	GO:0042110	289	0.058
positive regulation of binding	GO:0051099	49	0.058
digestive system development	GO:0055123	200	0.057
syncytium formation by plasma membrane fusion	GO:0000768	42	0.057
cellular response to biotic stimulus	GO:0071216	92	0.057
negative regulation of cell cycle process	GO:0010948	69	0.057
nucleosome disassembly	GO:0006337	1	0.057
regulation of neuron apoptotic process	GO:0043523	122	0.057
defense response to other organism	GO:0098542	197	0.057
negative regulation of cellular component organization	GO:0051129	194	0.057
placenta blood vessel development	GO:0060674	31	0.056
peptidyl serine modification	GO:0018209	83	0.056
protein modification by small protein conjugation	GO:0032446	187	0.056
g1 s transition of mitotic cell cycle	GO:0000082	57	0.056
axonogenesis	GO:0007409	274	0.055
cytokine production	GO:0001816	319	0.055
positive regulation of hydrolase activity	GO:0051345	148	0.055
clathrin coat assembly	GO:0048268	2	0.055
glucose homeostasis	GO:0042593	128	0.054
epithelial tube morphogenesis	GO:0060562	303	0.054
epithelial tube formation	GO:0072175	130	0.054
oogenesis	GO:0048477	56	0.054	Worm
negative regulation of protein maturation	GO:1903318	79	0.054
cytoplasmic transport	GO:0016482	234	0.053
purine ribonucleoside metabolic process	GO:0046128	241	0.053
positive regulation of neuron death	GO:1901216	28	0.053
regulation of fibroblast proliferation	GO:0048145	34	0.053
lipid modification	GO:0030258	65	0.053
regulation of cytokine production	GO:0001817	266	0.053
glycosyl compound metabolic process	GO:1901657	246	0.053
multicellular organismal aging	GO:0010259	24	0.053	Worm
regulation of striated muscle cell differentiation	GO:0051153	81	0.052
regulation of protein import into nucleus	GO:0042306	52	0.052
negative regulation of organelle organization	GO:0010639	90	0.052
dna recombination	GO:0006310	92	0.052
positive regulation of histone modification	GO:0031058	28	0.052
nucleobase containing small molecule metabolic process	GO:0055086	352	0.052
positive regulation of glucose metabolic process	GO:0010907	21	0.051
regulation of cellular response to insulin stimulus	GO:1900076	30	0.051
cellular response to inorganic substance	GO:0071241	37	0.050
blood vessel morphogenesis	GO:0048514	285	0.050
negative regulation of mitotic cell cycle phase transition	GO:1901991	45	0.050
regulation of cell motility	GO:2000145	236	0.050
negative regulation of transmembrane receptor protein serine threonine kinase signaling pathway	GO:0090101	61	0.050
lipid homeostasis	GO:0055088	63	0.049
alpha beta t cell differentiation	GO:0046632	69	0.049
nucleoside monophosphate metabolic process	GO:0009123	85	0.049
respiratory system development	GO:0060541	190	0.049
positive regulation of cysteine type endopeptidase activity involved in apoptotic process	GO:0043280	36	0.048
regulation of protein localization	GO:0032880	231	0.048
rhythmic process	GO:0048511	174	0.048
transforming growth factor beta receptor signaling pathway	GO:0007179	71	0.048
positive regulation of cell development	GO:0010720	237	0.048
glycosyl compound catabolic process	GO:1901658	206	0.048
b cell homeostasis	GO:0001782	34	0.047
regulation of muscle tissue development	GO:1901861	97	0.047
regulation of protein kinase activity	GO:0045859	232	0.047
regulation of nucleocytoplasmic transport	GO:0046822	73	0.047
heart morphogenesis	GO:0003007	178	0.046
positive regulation of cellular component biogenesis	GO:0044089	94	0.046
negative regulation of protein metabolic process	GO:0051248	282	0.046
regulation of protein maturation	GO:1903317	96	0.046
carbon catabolite regulation of transcription	GO:0045990	4	0.046
negative regulation of myeloid leukocyte differentiation	GO:0002762	20	0.046
organelle fission	GO:0048285	170	0.046
regulation of histone h3 k9 methylation	GO:0051570	8	0.045
negative regulation of neuron apoptotic process	GO:0043524	92	0.045
anatomical structure homeostasis	GO:0060249	145	0.045
response to organic cyclic compound	GO:0014070	198	0.045	Human
granulocyte differentiation	GO:0030851	17	0.045
negative regulation of cellular response to insulin stimulus	GO:1900077	16	0.045
positive regulation of peptidase activity	GO:0010952	49	0.045
mrna metabolic process	GO:0016071	84	0.044
innate immune response	GO:0045087	157	0.044
regulation of transcription from rna polymerase ii promoter in response to stress	GO:0043618	8	0.044
regulation of myeloid cell differentiation	GO:0045637	96	0.044
regulation of cysteine type endopeptidase activity involved in apoptotic process	GO:0043281	62	0.043
histone h3 k4 trimethylation	GO:0080182	5	0.043
positive regulation of behavior	GO:0048520	40	0.043
cellular response to starvation	GO:0009267	57	0.043
blood circulation	GO:0008015	195	0.043
forebrain development	GO:0030900	302	0.043
positive regulation of erk1 and erk2 cascade	GO:0070374	47	0.043
regulation of transmembrane receptor protein serine threonine kinase signaling pathway	GO:0090092	112	0.043
feeding behavior	GO:0007631	62	0.043
regulation of histone acetylation	GO:0035065	19	0.042
phagocytosis	GO:0006909	66	0.042
cell substrate adhesion	GO:0031589	130	0.042
negative regulation of cellular response to oxidative stress	GO:1900408	10	0.041
gonad development	GO:0008406	141	0.041
aromatic compound catabolic process	GO:0019439	286	0.041
carbohydrate derivative catabolic process	GO:1901136	231	0.041
ovulation cycle	GO:0042698	59	0.041
body morphogenesis	GO:0010171	45	0.041
positive regulation of proteolysis	GO:0045862	85	0.041
response to lipopolysaccharide	GO:0032496	128	0.041
male sex differentiation	GO:0046661	109	0.040
response to growth factor	GO:0070848	198	0.040
positive regulation of protein kinase activity	GO:0045860	144	0.040
carbon catabolite regulation of transcription from rna polymerase ii promoter	GO:0000429	4	0.040
macroautophagy	GO:0016236	21	0.040
negative regulation of protein modification process	GO:0031400	163	0.040
cation homeostasis	GO:0055080	212	0.040
hepaticobiliary system development	GO:0061008	67	0.039
regulation of bmp signaling pathway	GO:0030510	60	0.039
macromolecule deacylation	GO:0098732	37	0.039	Human
female gonad development	GO:0008585	71	0.039
myeloid cell homeostasis	GO:0002262	114	0.039
phospholipid biosynthetic process	GO:0008654	36	0.039
nucleoside metabolic process	GO:0009116	246	0.039
defense response to bacterium	GO:0042742	119	0.039
histone h4 k16 acetylation	GO:0043984	3	0.039
regulation of secretion	GO:0051046	274	0.039
positive regulation of apoptotic process involved in mammary gland involution	GO:0060058	4	0.039
striated muscle tissue development	GO:0014706	293	0.039
regulation of blood pressure	GO:0008217	93	0.039
nucleotide biosynthetic process	GO:0009165	78	0.038
regulation of cell cycle process	GO:0010564	160	0.038
regulation of protein transport	GO:0051223	163	0.038
negative regulation of mitotic cell cycle	GO:0045930	58	0.038
protein dna complex subunit organization	GO:0071824	28	0.038
nitrogen compound transport	GO:0071705	271	0.038
stress activated protein kinase signaling cascade	GO:0031098	81	0.038
protein modification by small protein conjugation or removal	GO:0070647	207	0.038
purine ribonucleoside monophosphate metabolic process	GO:0009167	80	0.038
muscle tissue development	GO:0060537	308	0.037
cell aging	GO:0007569	35	0.037
bone morphogenesis	GO:0060349	78	0.037
ribonucleoside monophosphate metabolic process	GO:0009161	80	0.037
phosphatidylinositol metabolic process	GO:0046488	45	0.037
amide transport	GO:0042886	138	0.037
regulation of transferase activity	GO:0051338	263	0.036
locomotory behavior	GO:0007626	195	0.036
regulation of protein processing	GO:0070613	96	0.036
response to fatty acid	GO:0070542	8	0.036
glucan metabolic process	GO:0044042	32	0.036
liver development	GO:0001889	66	0.036
mesoderm development	GO:0007498	100	0.036
oocyte differentiation	GO:0009994	35	0.036
leukocyte apoptotic process	GO:0071887	71	0.036
regulation of protein acetylation	GO:1901983	22	0.035
regulation of organ growth	GO:0046620	61	0.035
sensory perception	GO:0007600	245	0.035
negative regulation of gene silencing	GO:0060969	2	0.035
cellular response to reactive nitrogen species	GO:1902170	5	0.035
hindbrain development	GO:0030902	128	0.035
proteolysis involved in cellular protein catabolic process	GO:0051603	147	0.035
divalent inorganic cation transport	GO:0072511	178	0.035
establishment of protein localization to organelle	GO:0072594	118	0.035
regulation of cellular component biogenesis	GO:0044087	181	0.034
endocrine system development	GO:0035270	98	0.034
regulation of transforming growth factor beta receptor signaling pathway	GO:0017015	43	0.034
respiratory system process	GO:0003016	25	0.034
regulation of response to wounding	GO:1903034	189	0.034
glycerolipid biosynthetic process	GO:0045017	50	0.034
negative regulation of transferase activity	GO:0051348	85	0.034
positive regulation of cellular carbohydrate metabolic process	GO:0010676	29	0.034
bmp signaling pathway	GO:0030509	93	0.034
alpha amino acid metabolic process	GO:1901605	59	0.033
regulation of ossification	GO:0030278	112	0.033
response to oxygen radical	GO:0000305	16	0.033
activation of cysteine type endopeptidase activity involved in apoptotic process	GO:0006919	27	0.033
single organism nuclear import	GO:1902593	95	0.033
wound healing	GO:0042060	157	0.033
regulation of intrinsic apoptotic signaling pathway	GO:2001242	61	0.033
ribose phosphate metabolic process	GO:0019693	291	0.033
adaptive immune response	GO:0002250	155	0.033
response to transforming growth factor beta	GO:0071559	88	0.033
dna integrity checkpoint	GO:0031570	28	0.033

Ep300 disease predictions

Disease predictions are made from cross-annotation of human disease genes to the identified functional analogs in mouse and predicted with the mouse functional network.

Disease	DO term ID	Probability	Func Analog Org
cancer	DOID:162	0.434	Human
disease of cellular proliferation	DOID:14566	0.434	Human
large intestine cancer	DOID:5672	0.194	Human
colon cancer	DOID:219	0.194	Human
gastrointestinal system cancer	DOID:3119	0.194	Human
intestinal cancer	DOID:10155	0.194	Human
organ system cancer	DOID:0050686	0.194	Human
colorectal cancer	DOID:9256	0.194	Human
thoracic cancer	DOID:5093	0.054
breast cancer	DOID:1612	0.033

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