Mus musculus

0 known processes

Fam19a5

family with sequence similarity 19, member A5

(Aliases: AW049604,Tafa-5,Tara-5,TAFA5)

Fam19a5 biological process predictions


Filter by process size:
Biological processGO term IDProcess sizeProbabilityFunc Analog Org
axonogenesisGO:00074092740.380
regulation of cellular amine metabolic processGO:0033238200.310
amine metabolic processGO:0009308450.223
membrane organizationGO:00610242450.193
chemotaxisGO:00069352470.181
regulation of alpha amino 3 hydroxy 5 methyl 4 isoxazole propionate selective glutamate receptor activityGO:2000311110.176
regulation of membrane potentialGO:00423911920.169
defecationGO:003042110.140
positive regulation of nervous system developmentGO:00519622210.126
regulation of cellular ketone metabolic processGO:0010565660.117
regulation of glutamate receptor signaling pathwayGO:1900449160.101
positive regulation of cellular amine metabolic processGO:003324050.100
neuron projection guidanceGO:00974851410.100
cellular ketone metabolic processGO:0042180840.099
regulation of long term synaptic depressionGO:190045230.090
regulation of neuron differentiationGO:00456642810.084
cellular amino acid metabolic processGO:00065201030.075
transmembrane receptor protein tyrosine kinase signaling pathwayGO:00071692470.074
protein modification by small protein conjugation or removalGO:00706472070.070
cellular amine metabolic processGO:0044106440.070
regulation of cellular amino acid metabolic processGO:000652150.063
regulation of receptor activityGO:0010469410.062
positive regulation of cellular amino acid metabolic processGO:004576430.062
regulation of transferase activityGO:00513382630.061
positive regulation of cell developmentGO:00107202370.060
negative regulation of neuron differentiationGO:00456651010.059
cell adhesionGO:00071553290.058
cognitionGO:00508901490.058
neuron neuron synaptic transmissionGO:0007270690.057
negative regulation of nervous system developmentGO:00519611560.055
axon guidanceGO:00074111410.054
positive regulation of neuron differentiationGO:00456661410.054
striated muscle tissue developmentGO:00147062930.054
regulation of cell projection organizationGO:00313442060.053
neurotransmitter transportGO:0006836760.051
terminal button organizationGO:007255330.050
regulation of protein kinase activityGO:00458592320.047
maintenance of presynaptic active zone structureGO:004879010.047
neurotransmitter secretionGO:0007269620.046
mapk cascadeGO:00001652810.044
glutamate receptor signaling pathwayGO:0007215350.044
actin cytoskeleton organizationGO:00300362200.044
transmembrane transportGO:00550854120.044
negative regulation of molecular functionGO:00440922580.042
dorsal ventral axon guidanceGO:003356330.041
regulation of neuron projection developmentGO:00109751690.041
tube formationGO:00351481400.040
proteolysis involved in cellular protein catabolic processGO:00516031470.040
regulation of organelle organizationGO:00330432890.040
membrane depolarizationGO:0051899640.040
nitrogen compound transportGO:00717052710.040
microtubule based processGO:00070172360.040
regulation of neurotransmitter levelsGO:0001505870.039
ion transmembrane transportGO:00342203610.039
nucleoside phosphate metabolic processGO:00067533380.039
synaptic transmissionGO:00072683290.039
positive regulation of protein kinase activityGO:00458601440.039
inner ear morphogenesisGO:00424721010.039
macromolecule catabolic processGO:00090572810.039
negative regulation of synapse assemblyGO:005196430.038
connective tissue developmentGO:00614481790.038
muscle tissue developmentGO:00605373080.038
negative regulation of protein metabolic processGO:00512482820.038
regulation of cell morphogenesis involved in differentiationGO:00107691510.037
regulation of cell migrationGO:00303342190.037
regulation of secretion by cellGO:19035302490.037
organonitrogen compound biosynthetic processGO:19015661920.037
protein catabolic processGO:00301632210.036
urogenital system developmentGO:00016552610.036
regulation of asymmetric cell divisionGO:000978640.036
ear developmentGO:00435832000.036
multicellular organismal signalingGO:0035637910.035
neuronal action potentialGO:0019228540.035
cation transportGO:00068123990.035
peptidyl amino acid modificationGO:00181933360.035
cation transmembrane transportGO:00986552660.034
small gtpase mediated signal transductionGO:0007264970.034
regulation of cell motilityGO:20001452360.034
protein targetingGO:00066051430.034
regulation of wnt signaling pathwayGO:00301111230.034
sensory organ morphogenesisGO:00905962420.034
intracellular protein transportGO:00068862040.034
regulation of synaptic growth at neuromuscular junctionGO:000858240.033
microtubule based movementGO:0007018840.033
modification dependent macromolecule catabolic processGO:00436321330.033
regulation of terminal button organizationGO:200033110.032
rhythmic processGO:00485111740.032
ubiquitin dependent protein catabolic processGO:00065111290.032
establishment of endothelial blood brain barrierGO:001404530.032
compound eye developmentGO:004874910.031
regulation of synaptic transmission glutamatergicGO:0051966190.030
regulation of anterior head developmentGO:200074220.030
wnt signaling pathway involved in forebrain neuroblast divisionGO:002187420.029
central nervous system neuron differentiationGO:00219531620.029
cerebellum formationGO:002158810.029
positive regulation of protein phosphorylationGO:00019342420.029
learningGO:0007612980.029
peptide transportGO:00158331330.029
renal system developmentGO:00720012250.028
peptidyl tyrosine modificationGO:00182121450.028
apoptotic signaling pathwayGO:00971903060.028
positive regulation of interleukin 8 productionGO:003275720.028
nucleotide metabolic processGO:00091173320.028
transmission of nerve impulseGO:0019226760.028
hindbrain developmentGO:00309021280.028
protein modification by small protein conjugationGO:00324461870.028
cytoplasmic transportGO:00164822340.027
cellular protein catabolic processGO:00442571550.027
positive regulation of wnt signaling pathwayGO:0030177450.027
positive regulation of protein modification processGO:00314012990.027
regulation of defense responseGO:00313472330.027
establishment of protein localization to organelleGO:00725941180.027
modification dependent protein catabolic processGO:00199411330.027
retina development in camera type eyeGO:00600411190.027
regulation of mapk cascadeGO:00434082480.027
ensheathment of neuronsGO:0007272760.027
single organism cell adhesionGO:00986021560.027
canonical wnt signaling pathwayGO:00600701300.026
oxygen homeostasisGO:003236420.026
regulation of vesicle mediated transportGO:00606271390.026
regulation of actin filament based processGO:0032970990.026
cellular macromolecule catabolic processGO:00442652060.026
epithelial tube formationGO:00721751300.026
establishment of planar polarity involved in neural tube closureGO:0090177150.026
peptidyl tyrosine phosphorylationGO:00181081430.026
somatotropin secreting cell differentiationGO:006012640.026
axon ensheathmentGO:0008366760.026
embryonic organ morphogenesisGO:00485622760.025
protein ubiquitinationGO:00165671710.025
single fertilizationGO:0007338820.025
cell proliferation in external granule layerGO:0021924100.025
lymphocyte differentiationGO:00300982420.025
negative regulation of neuron projection developmentGO:0010977500.025
non canonical wnt signaling pathwayGO:0035567330.025
positive regulation of transferase activityGO:00513471670.025
synapse organizationGO:00508081250.025
cyclic nucleotide biosynthetic processGO:0009190440.025
epithelial tube morphogenesisGO:00605623030.025
response to organonitrogen compoundGO:00102432460.025
purine containing compound biosynthetic processGO:0072522700.025
protein localization to organelleGO:00333651850.024
pallium developmentGO:00215431200.024
cardiac muscle tissue developmentGO:00487381300.024
endocytosisGO:00068971680.024
regulation of system processGO:00440572000.024
myelinationGO:0042552740.024
angiogenesisGO:00015252010.024
organophosphate biosynthetic processGO:00904071220.023
transmembrane receptor protein serine threonine kinase signaling pathwayGO:00071781940.023
negative regulation of cellular component organizationGO:00511291940.023
telencephalon developmentGO:00215371860.023
hormone secretionGO:00468791280.023
negative regulation of canonical wnt signaling pathwayGO:0090090510.023
cellular response to growth factor stimulusGO:00713631970.023
rhombomere morphogenesisGO:002159320.023
regionalizationGO:00030023370.023
nucleotide biosynthetic processGO:0009165780.022
regulation of hormone levelsGO:00108172110.022
myeloid cell differentiationGO:00300992330.022
synaptic transmission glutamatergicGO:0035249360.022
heart morphogenesisGO:00030071780.022
cell type specific apoptotic processGO:00972852680.022
compartment pattern specificationGO:000738640.022
establishment of vesicle localizationGO:0051650810.022
ribose phosphate biosynthetic processGO:0046390590.022
fat cell differentiationGO:00454441600.021
establishment of organelle localizationGO:00516561220.021
neural precursor cell proliferationGO:00613511210.021
peripheral nervous system neuron axonogenesisGO:004893630.021
memoryGO:0007613580.021
regulation of kinase activityGO:00435492490.020
cell cell adhesion via plasma membrane adhesion moleculesGO:0098742400.020
development of primary sexual characteristicsGO:00451371430.020
exocytosisGO:00068871210.020
methylationGO:00322591340.020
kidney epithelium developmentGO:00720731210.020
wnt signaling pathway planar cell polarity pathwayGO:0060071270.020
cell fate commitmentGO:00451652100.020
renal vesicle morphogenesisGO:0072077150.020
organelle fissionGO:00482851700.020
muscle cell differentiationGO:00426922610.020
non canonical wnt signaling pathway involved in heart developmentGO:006134130.020
cerebral cortex developmentGO:0021987860.020
second messenger mediated signalingGO:0019932730.020
carbohydrate derivative biosynthetic processGO:19011371830.020
positive regulation of neuron projection developmentGO:0010976790.020
regulation of transporter activityGO:0032409570.020
nucleocytoplasmic transportGO:00069131390.020
respiratory system developmentGO:00605411900.020
neuromuscular process controlling balanceGO:0050885590.020
protein import into nucleusGO:0006606950.019
axon cargo transportGO:0008088330.019
establishment of planar polarity of embryonic epitheliumGO:0042249160.019
negative regulation of cell developmentGO:00107211690.019
metanephric nephron developmentGO:0072210340.019
forebrain developmentGO:00309003020.019
action potentialGO:0001508780.019
asymmetric neuroblast divisionGO:005505910.019
skin developmentGO:00435882200.019
cellular homeostasisGO:00197252400.019
canonical wnt signaling pathway involved in regulation of type b pancreatic cell proliferationGO:004434310.019
positive regulation of peptidyl tyrosine phosphorylationGO:0050731610.019
ameboidal type cell migrationGO:00016671280.019
organ growthGO:00352651170.019
fast calcium ion dependent exocytosis of neurotransmitterGO:009874610.019
cellular lipid metabolic processGO:00442553230.019
nuclear divisionGO:00002801580.018
regulation of secretionGO:00510462740.018
peptide secretionGO:00027901140.018
epithelial cell developmentGO:00020641590.018
kidney morphogenesisGO:0060993830.018
skeletal muscle cell differentiationGO:0035914660.018
regulation of ovulationGO:006027830.018
positive regulation of anagenGO:005188510.018
peptide hormone secretionGO:00300721090.018
regulation of feeding behaviorGO:006025930.018
branching morphogenesis of an epithelial tubeGO:00487541590.018
reactive oxygen species metabolic processGO:0072593840.018
rho protein signal transductionGO:0007266320.018
rhombomere formationGO:002159410.018
tissue migrationGO:0090130680.017
regulation of cell cycleGO:00517262810.017
cell recognitionGO:0008037830.017
regulation of transmembrane receptor protein serine threonine kinase signaling pathwayGO:00900921120.017
tube closureGO:0060606910.017
organelle localizationGO:00516401790.017
male sex differentiationGO:00466611090.017
camera type eye developmentGO:00430102660.017
regulation of vasculature developmentGO:1901342880.017
cardiac muscle cell proliferationGO:0060038310.017
nephron epithelium morphogenesisGO:0072088680.017
plasma membrane organizationGO:0007009900.017
ear morphogenesisGO:00424711180.016
central nervous system vasculogenesisGO:002200930.016
ribose phosphate metabolic processGO:00196932910.016
regulation of striated muscle cell differentiationGO:0051153810.016
kidney developmentGO:00018222130.016
planar cell polarity pathway involved in ventricular septum morphogenesisGO:006134820.016
skeletal muscle satellite cell maintenance involved in skeletal muscle regenerationGO:001483430.016
male gamete generationGO:00482322850.016
synapse assemblyGO:0007416560.016
purine ribonucleotide biosynthetic processGO:0009152590.016
cell chemotaxisGO:0060326810.016
regulation of postsynaptic membrane potentialGO:0060078480.016
fertilizationGO:00095661270.016
vesicle localizationGO:0051648860.016
regulation of cellular response to growth factor stimulusGO:0090287820.016
regulation of gamma aminobutyric acid secretionGO:001405220.016
spemann organizer formationGO:006006120.016
cyclic nucleotide metabolic processGO:0009187590.016
female gamete generationGO:0007292740.016
positive regulation of behaviorGO:0048520400.016
regulation of endocytosisGO:0030100690.016
regulation of sequence specific dna binding transcription factor activityGO:00510901060.016
dendrite developmentGO:00163581150.016
circulatory system processGO:00030131970.016
monosaccharide metabolic processGO:00059961060.016
morphogenesis of embryonic epitheliumGO:00163311590.016
mitral valve developmentGO:000317440.016
metencephalon developmentGO:0022037890.016
midgut developmentGO:000749440.016
negative regulation of cellular protein metabolic processGO:00322692470.016
positive regulation of mapk cascadeGO:00434101700.016
dendrite self avoidanceGO:007059320.016
primary neural tube formationGO:0014020950.016
nucleoside phosphate biosynthetic processGO:1901293790.015
regulation of apoptotic signaling pathwayGO:20012331970.015
regulation of establishment of planar polarityGO:0090175280.015
uterus morphogenesisGO:006103820.015
spermatogenesisGO:00072832840.015
glial cell differentiationGO:00100011310.015
peripheral nervous system axon regenerationGO:001401220.015
tertiary branching involved in mammary gland duct morphogenesisGO:006074830.015
stem cell proliferationGO:00720891170.015
posttranscriptional regulation of gene expressionGO:00106081550.015
cellular chemical homeostasisGO:00550822150.015
spinal cord ventral commissure morphogenesisGO:002196520.015
response to growth factorGO:00708481980.015
ureteric bud morphogenesisGO:0060675620.015
lung developmentGO:00303241640.015
amide transportGO:00428861380.015
leukocyte differentiationGO:00025213420.015
lateral line system developmentGO:004892510.015
meiotic cell cycleGO:00513211220.015
regulation of rna polymerase ii transcriptional preinitiation complex assemblyGO:004589820.015
nephron epithelium developmentGO:0072009920.015
locomotory behaviorGO:00076261950.015
postsynaptic membrane organizationGO:0001941180.015
cerebellum developmentGO:0021549770.015
netrin activated signaling pathwayGO:003800710.015
negative regulation of triglyceride biosynthetic processGO:001086820.015
positive regulation of kinase activityGO:00336741550.015
embryonic epithelial tube formationGO:00018381300.015
gonad developmentGO:00084061410.015
establishment of synaptic vesicle localizationGO:0097480570.015
regulation of peptidyl tyrosine phosphorylationGO:0050730930.015
cell proliferation in forebrainGO:0021846300.014
actomyosin structure organizationGO:0031032560.014
cerebellar cortex developmentGO:0021695480.014
positive regulation of apoptotic processGO:00430652170.014
negative regulation of protein modification processGO:00314001630.014
neuromuscular processGO:0050905990.014
cervix developmentGO:006006720.014
nuclear importGO:0051170950.014
retina morphogenesis in camera type eyeGO:0060042450.014
cerebellum morphogenesisGO:0021587420.014
regulation of engulfment of apoptotic cellGO:190107420.014
response to monosaccharideGO:0034284670.014
synaptic vesicle transportGO:0048489570.014
neural retina developmentGO:0003407410.014
regulation of ion transportGO:00432692150.014
regulation of excitatory postsynaptic membrane potentialGO:0060079410.014
protein maturationGO:00516041760.014
cellular response to heparinGO:007150410.014
single organismal cell cell adhesionGO:00163371310.014
oligodendrocyte differentiationGO:0048709530.014
nuclear transportGO:00511691390.014
purine nucleotide biosynthetic processGO:0006164650.014
ras protein signal transductionGO:0007265770.014
regulation of map kinase activityGO:00434051200.014
developmental growth involved in morphogenesisGO:00605601380.014
t cell activationGO:00421102890.014
positive regulation of schwann cell proliferationGO:001062510.014
central nervous system segmentationGO:003528330.014
microtubule based transportGO:0010970500.014
female gonad developmentGO:0008585710.014
positive regulation of ossificationGO:0045778470.014
glial cell developmentGO:0021782540.013
central nervous system projection neuron axonogenesisGO:0021952210.013
nephron morphogenesisGO:0072028690.013
neural tube formationGO:00018411080.013
mesonephric duct morphogenesisGO:007218040.013
planar cell polarity pathway involved in outflow tract morphogenesisGO:006134720.013
cardiocyte differentiationGO:0035051870.013
regulation of protein ubiquitinationGO:0031396520.013
brain segmentationGO:003528430.013
synaptic vesicle localizationGO:0097479590.013
meiotic nuclear divisionGO:00071261150.013
segmentationGO:0035282930.013
triglyceride biosynthetic processGO:0019432170.013
negative regulation of cell projection organizationGO:0031345560.013
lung smooth muscle developmentGO:006114520.013
regulation of cell adhesionGO:00301551540.013
negative regulation of dendritic spine developmentGO:006100030.013
lateral sprouting involved in mammary gland duct morphogenesisGO:006059920.013
blood circulationGO:00080151950.013
germ cell developmentGO:00072811850.013
regulation of lymphocyte activationGO:00512492400.013
negative regulation of immune system processGO:00026832090.013
sensory perception of umami tasteGO:005091740.013
wnt signaling pathwayGO:00160551880.013
central nervous system neuron developmentGO:0021954670.013
camp biosynthetic processGO:0006171310.013
positive regulation of cell motilityGO:20001471160.013
positive regulation of rna polymerase ii transcriptional preinitiation complex assemblyGO:004589920.013
testosterone biosynthetic processGO:006137020.013
asymmetric stem cell divisionGO:009872230.012
establishment of tissue polarityGO:0007164280.012
developmental inductionGO:0031128340.012
cerebral cortex cell migrationGO:0021795440.012
metanephros developmentGO:0001656790.012
g protein coupled receptor signaling pathwayGO:00071862430.012
regulation of exocytosisGO:0017157610.012
cytoskeleton dependent intracellular transportGO:0030705500.012
response to parathyroid hormoneGO:007110730.012
gonad morphogenesisGO:003526210.012
regulation of cell activationGO:00508652890.012
metanephric loop of henle developmentGO:007223640.012
regulation of neurotransmitter transportGO:0051588350.012
negative regulation of cell proliferationGO:00082852960.012
olfactory learningGO:000835520.012
cardiac muscle cell differentiationGO:0055007690.012
renal outer medulla developmentGO:007205420.012
renal vesicle inductionGO:007203430.012
pharynx developmentGO:006046510.012
negative regulation of mesenchymal cell proliferationGO:007220130.012
forebrain generation of neuronsGO:0021872630.012
metanephros morphogenesisGO:0003338240.012
cartilage developmentGO:00512161400.012
positive regulation of cell projection organizationGO:0031346950.012
synaptic vesicle exocytosisGO:0016079260.012
metanephric nephron morphogenesisGO:0072273190.012
cell proliferation in midbrainGO:003327820.012
positive regulation of mesonephros developmentGO:0061213200.012
regulation of neural precursor cell proliferationGO:2000177700.012
positive regulation of leukocyte differentiationGO:1902107860.012
g protein coupled acetylcholine receptor signaling pathwayGO:000721340.012
regulation of leukocyte differentiationGO:19021051590.012
positive regulation of growthGO:00459271040.012
negative regulation of dendritic spine morphogenesisGO:006100230.012
renal vesicle developmentGO:0072087170.012
zygotic determination of anterior posterior axis embryoGO:000735430.012
carbohydrate biosynthetic processGO:0016051740.012
cell cell adhesionGO:0098609410.012
positive regulation of synaptic transmission gabaergicGO:003223080.012
central nervous system neuron axonogenesisGO:0021955280.012
response to transforming growth factor betaGO:0071559880.012
gliogenesisGO:00420631410.012
midbrain hindbrain boundary maturationGO:002173210.012
planar cell polarity pathway involved in cardiac right atrium morphogenesisGO:006134920.011
response to peptideGO:19016521360.011
cellular component assembly involved in morphogenesisGO:00109271390.011
positive regulation of programmed cell deathGO:00430682180.011
regulation of chemotaxisGO:0050920530.011
t cell differentiation in thymusGO:0033077770.011
regulation of actin cytoskeleton organizationGO:0032956840.011
neuron recognitionGO:0008038250.011
protein processingGO:00164851630.011
negative regulation of intracellular signal transductionGO:19025321670.011
primary prostatic bud elongationGO:006051620.011
central nervous system morphogenesisGO:002155120.011
single organism nuclear importGO:1902593950.011
regulation of ossificationGO:00302781120.011
maintenance of locationGO:0051235890.011
establishment of planar polarity involved in nephron morphogenesisGO:007204610.011
purine containing compound metabolic processGO:00725213110.011
carbohydrate homeostasisGO:00335001280.011
regulation of protein modification by small protein conjugation or removalGO:1903320570.011
extracellular structure organizationGO:00430621480.011
positive regulation of protein serine threonine kinase activityGO:00719021060.011
learning or memoryGO:00076111480.011
regulation of muscle tissue developmentGO:1901861970.011
endomembrane system organizationGO:00102561470.011
positive regulation of non canonical wnt signaling pathwayGO:200005260.011
golgi vesicle transportGO:0048193300.011
activation of adenylate cyclase activityGO:000719040.011
development of primary male sexual characteristicsGO:0046546880.011
macromolecule methylationGO:00434141200.011
cellular carbohydrate metabolic processGO:00442621190.011
smoothened signaling pathwayGO:00072241050.011
cyclic purine nucleotide metabolic processGO:0052652430.011
synaptic vesicle membrane organizationGO:004849910.011
mitral valve morphogenesisGO:000318340.011
respiratory tube developmentGO:00303231670.011
calcium ion transmembrane transportGO:0070588850.011
regulation of myeloid cell differentiationGO:0045637960.011
multi organism behaviorGO:0051705620.011
morphogenesis of a polarized epitheliumGO:0001738370.011
epithelial cell migrationGO:0010631630.011
retrograde transport endosome to golgiGO:004214720.011
engulfment of apoptotic cellGO:004365230.011
hindbrain morphogenesisGO:0021575460.010
regulation of peptide transportGO:0090087910.010
regulation of cytoskeleton organizationGO:00514931220.010
positive regulation of cell activationGO:00508671580.010
regulation of nucleocytoplasmic transportGO:0046822730.010
regulation of transforming growth factor beta receptor signaling pathwayGO:0017015430.010
soft palate developmentGO:006002320.010
regulation of epithelial cell proliferationGO:00506781410.010
negative regulation of photoreceptor cell differentiationGO:004653340.010
regulation of cellular protein catabolic processGO:1903362610.010
neuron deathGO:00709971540.010
formation of organ boundaryGO:001016010.010
positive regulation of canonical wnt signaling pathway involved in controlling type b pancreatic cell proliferationGO:200008110.010
positive regulation of epithelial cell differentiation involved in kidney developmentGO:200069820.010
regulation of protein catabolic processGO:00421761080.010
spemann organizer formation at the anterior end of the primitive streakGO:006006410.010
nephron tubule morphogenesisGO:0072078680.010
organic hydroxy compound biosynthetic processGO:1901617770.010
planar cell polarity pathway involved in heart morphogenesisGO:006134630.010
regulation of anatomical structure sizeGO:00900661780.010
negative regulation of bmp signaling pathwayGO:0030514350.010
regulation of response to woundingGO:19030341890.010
regulation of cell cell adhesion mediated by cadherinGO:200004720.010
negative regulation of wnt signaling pathwayGO:0030178730.010
negative regulation of cell motilityGO:2000146610.010
positive regulation of osteoblast differentiationGO:0045669340.010
ureteric bud developmentGO:0001657940.010
neuron maturationGO:0042551290.010

Fam19a5 disease predictions

Disease predictions are made from cross-annotation of human disease genes to the identified functional analogs in mouse and predicted with the mouse functional network.

DiseaseDO term IDSizeProbabilityFunc Analog Org
nervous system diseaseDOID:86300.015
disease of anatomical entityDOID:700.015
neuropathyDOID:87000.012