IMP: Integrative Multi-species Prediction

Mus musculus

12 known processes

Serpina3c

serine (or cysteine) peptidase inhibitor, clade A, member 3C

(Aliases: spi2,Klkbp,1A1,MGC144822,Kalbp)

Ensembl: ENSMUSG00000066361
Entrez: 16625
UniProtKB: P29621

Process Predictions
Disease Predictions

Serpina3c biological process predictions

Show only novel predictionsHighlight processes of functional analogs

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Biological process	GO term ID	Process size	Probability	Func Analog Org
negative regulation of gluconeogenesis	GO:0045721	9	0.792	Mouse
cellular ketone metabolic process	GO:0042180	84	0.695	Mouse
triglyceride metabolic process	GO:0006641	51	0.597	Mouse
acylglycerol metabolic process	GO:0006639	55	0.495	Mouse
positive regulation of protein kinase c activity	GO:1900020	1	0.478
male gamete generation	GO:0048232	285	0.443	Mouse
regulation of protein kinase c activity	GO:1900019	1	0.386
regulation of cellular ketone metabolic process	GO:0010565	66	0.384	Mouse
cellular lipid metabolic process	GO:0044255	323	0.370	Mouse
neutral lipid metabolic process	GO:0006638	57	0.324	Mouse
cellular response to peptide	GO:1901653	92	0.320	Mouse
cellular amino acid metabolic process	GO:0006520	103	0.311
regulation of renal output by angiotensin	GO:0002019	2	0.297
spermatogenesis	GO:0007283	284	0.272	Mouse
response to peptide hormone	GO:0043434	127	0.258
regulation of lipid metabolic process	GO:0019216	118	0.248	Mouse
response to insulin	GO:0032868	100	0.237	Mouse
hexose biosynthetic process	GO:0019319	39	0.224	Mouse
sterol metabolic process	GO:0016125	58	0.224	Mouse
defense response to other organism	GO:0098542	197	0.223
positive regulation of apoptotic process	GO:0043065	217	0.221	Rat
regulation of cellular amino acid metabolic process	GO:0006521	5	0.219
negative regulation of lipid metabolic process	GO:0045833	30	0.218	Mouse
cellular response to peptide hormone stimulus	GO:0071375	92	0.210	Mouse
regulation of cellular amine metabolic process	GO:0033238	20	0.194
positive regulation of fatty acid biosynthetic process	GO:0045723	3	0.188
immune effector process	GO:0002252	321	0.184
lipid biosynthetic process	GO:0008610	179	0.183	Mouse
cellular response to organonitrogen compound	GO:0071417	145	0.180	Mouse
carbohydrate biosynthetic process	GO:0016051	74	0.168	Mouse
cellular response to hormone stimulus	GO:0032870	150	0.167	Mouse
activation of nf kappab inducing kinase activity	GO:0007250	4	0.166
carbohydrate metabolic process	GO:0005975	230	0.160	Mouse
regulation of secretion by cell	GO:1903530	249	0.158
adaptive immune response based on somatic recombination of immune receptors built from immunoglobulin superfamily domains	GO:0002460	145	0.158
glycoprotein metabolic process	GO:0009100	116	0.156	Mouse
positive regulation of insulin receptor signaling pathway	GO:0046628	4	0.151	Mouse
regulation of triglyceride metabolic process	GO:0090207	17	0.150	Mouse
glycoprotein biosynthetic process	GO:0009101	89	0.149	Mouse
cholesterol metabolic process	GO:0008203	56	0.142	Mouse
cellular response to insulin stimulus	GO:0032869	78	0.140	Mouse
activation of immune response	GO:0002253	138	0.134
response to peptide	GO:1901652	136	0.131
regulation of glucose metabolic process	GO:0010906	60	0.130	Mouse
glycerolipid metabolic process	GO:0046486	122	0.129	Mouse
protein processing	GO:0016485	163	0.124	Mouse
leukocyte mediated immunity	GO:0002443	174	0.123
fatty acid metabolic process	GO:0006631	121	0.121
positive regulation of cellular amine metabolic process	GO:0033240	5	0.120
regulation of inflammatory response	GO:0050727	147	0.120
negative regulation of protein metabolic process	GO:0051248	282	0.119	Mouse
astrocyte activation	GO:0048143	2	0.118
cellular response to cytokine stimulus	GO:0071345	189	0.116
monosaccharide biosynthetic process	GO:0046364	44	0.115	Mouse
regulation of carbohydrate metabolic process	GO:0006109	75	0.114	Mouse
inflammatory response	GO:0006954	244	0.112
response to organonitrogen compound	GO:0010243	246	0.109
regulation of carbohydrate biosynthetic process	GO:0043255	40	0.109	Mouse
macromolecule glycosylation	GO:0043413	55	0.107	Mouse
glycosylation	GO:0070085	62	0.104	Mouse
defense response to bacterium	GO:0042742	119	0.104
monocarboxylic acid metabolic process	GO:0032787	191	0.104
response to lipopolysaccharide	GO:0032496	128	0.104
lymphocyte mediated immunity	GO:0002449	139	0.100
amine metabolic process	GO:0009308	45	0.100
response to molecule of bacterial origin	GO:0002237	143	0.100
regulation of fatty acid metabolic process	GO:0019217	28	0.099
positive regulation of cellular amino acid metabolic process	GO:0045764	3	0.098
transmembrane receptor protein tyrosine kinase signaling pathway	GO:0007169	247	0.098	Mouse
regulation of insulin receptor signaling pathway	GO:0046626	21	0.095	Mouse
positive regulation of transferase activity	GO:0051347	167	0.094
negative regulation of cellular carbohydrate metabolic process	GO:0010677	19	0.093	Mouse
adaptive immune response	GO:0002250	155	0.092
insulin receptor signaling pathway	GO:0008286	49	0.090	Mouse
smooth muscle contraction	GO:0006939	44	0.089
regulation of endopeptidase activity	GO:0052548	89	0.089	Mouse
ovarian follicle rupture	GO:0001543	2	0.089
positive regulation of cytokine production	GO:0001819	174	0.088
positive regulation of protein phosphorylation	GO:0001934	242	0.087
monosaccharide metabolic process	GO:0005996	106	0.085	Mouse
steroid metabolic process	GO:0008202	119	0.084	Mouse
macromolecule catabolic process	GO:0009057	281	0.083
protein n linked glycosylation	GO:0006487	12	0.083	Mouse
peptidyl amino acid modification	GO:0018193	336	0.083
regulation of cholesterol metabolic process	GO:0090181	14	0.082	Mouse
regulation of lipid biosynthetic process	GO:0046890	54	0.079	Mouse
positive regulation of mapk cascade	GO:0043410	170	0.079
regulation of kinase activity	GO:0043549	249	0.077
cell type specific apoptotic process	GO:0097285	268	0.077
cellular response to testosterone stimulus	GO:0071394	1	0.074
mapk cascade	GO:0000165	281	0.073
regulation of response to wounding	GO:1903034	189	0.073
regulation of protein serine threonine kinase activity	GO:0071900	157	0.073
regulation of gluconeogenesis	GO:0006111	30	0.072	Mouse
regulation of protein kinase activity	GO:0045859	232	0.070
positive regulation of cell death	GO:0010942	224	0.067	Rat
positive regulation of cytokine secretion	GO:0050715	41	0.066
positive regulation of lipid metabolic process	GO:0045834	40	0.066
regulation of hormone levels	GO:0010817	211	0.064
protein activation cascade	GO:0072376	19	0.064
glucocorticoid metabolic process	GO:0008211	9	0.064	Mouse
regulation of lymphocyte mediated immunity	GO:0002706	84	0.063
regulation of defense response	GO:0031347	233	0.062
negative regulation of carbohydrate metabolic process	GO:0045912	19	0.061	Mouse
negative regulation of molecular function	GO:0044092	258	0.061	Mouse
fatty acid biosynthetic process	GO:0006633	41	0.061
establishment of blood nerve barrier	GO:0008065	3	0.061
regulation of protein processing	GO:0070613	96	0.060	Mouse
negative regulation of protein processing	GO:0010955	79	0.060	Mouse
carbohydrate derivative biosynthetic process	GO:1901137	183	0.058	Mouse
cellular carbohydrate metabolic process	GO:0044262	119	0.056	Mouse
negative regulation of cellular protein metabolic process	GO:0032269	247	0.056	Mouse
positive regulation of protein serine threonine kinase activity	GO:0071902	106	0.056
regulation of adaptive immune response	GO:0002819	90	0.054
regulation of fatty acid biosynthetic process	GO:0042304	12	0.054
innate immune response	GO:0045087	157	0.053
regulation of transferase activity	GO:0051338	263	0.053
regulation of phosphatidylinositol 3 kinase signaling	GO:0014066	30	0.052	Mouse
negative regulation of phosphorylation	GO:0042326	166	0.051
regulation of mapk cascade	GO:0043408	248	0.051
alcohol metabolic process	GO:0006066	116	0.050	Mouse
protein glycosylation	GO:0006486	55	0.049	Mouse
renin angiotensin regulation of aldosterone production	GO:0002018	3	0.049
ureteric bud development	GO:0001657	94	0.049
maintenance of location	GO:0051235	89	0.048
female sex differentiation	GO:0046660	84	0.046
organic acid biosynthetic process	GO:0016053	86	0.046
regulation of cell activation	GO:0050865	289	0.045
production of molecular mediator of immune response	GO:0002440	103	0.045
regulation of protein maturation	GO:1903317	96	0.044	Mouse
acute inflammatory response	GO:0002526	41	0.044
positive regulation of innate immune response	GO:0045089	80	0.044
regulation of systemic arterial blood pressure by circulatory renin angiotensin	GO:0001991	13	0.044
complement activation	GO:0006956	16	0.043
mesonephros development	GO:0001823	97	0.043
angiotensin mediated vasoconstriction involved in regulation of systemic arterial blood pressure	GO:0001998	3	0.043
cytokine production	GO:0001816	319	0.042
negative regulation of multi organism process	GO:0043901	68	0.041
regulation of multi organism process	GO:0043900	111	0.041
organic hydroxy compound metabolic process	GO:1901615	203	0.041	Mouse
positive regulation of adaptive immune response based on somatic recombination of immune receptors built from immunoglobulin superfamily domains	GO:0002824	61	0.041
regulation of protein transport	GO:0051223	163	0.040
positive regulation of programmed cell death	GO:0043068	218	0.040	Rat
hexose metabolic process	GO:0019318	98	0.040	Mouse
positive regulation of secretion	GO:0051047	130	0.039
protein maturation	GO:0051604	176	0.039	Mouse
small molecule biosynthetic process	GO:0044283	132	0.039
positive regulation of protein modification process	GO:0031401	299	0.039
negative regulation of intracellular signal transduction	GO:1902532	167	0.038
peptidyl serine phosphorylation	GO:0018105	74	0.038
amide transport	GO:0042886	138	0.038
regulation of secretion	GO:0051046	274	0.038
gluconeogenesis	GO:0006094	39	0.038	Mouse
regulation of phospholipase c activity	GO:1900274	3	0.038
negative regulation of protein maturation	GO:1903318	79	0.038	Mouse
negative regulation of immune system process	GO:0002683	209	0.037
cation transport	GO:0006812	399	0.037
female gonad development	GO:0008585	71	0.037
cell matrix adhesion	GO:0007160	68	0.037
response to stilbenoid	GO:0035634	22	0.037
neutrophil mediated killing of gram positive bacterium	GO:0070946	2	0.037
carboxylic acid biosynthetic process	GO:0046394	86	0.036
b cell mediated immunity	GO:0019724	71	0.036
negative regulation of neuron death	GO:1901215	98	0.035
cytokine secretion	GO:0050663	72	0.035
regulation of vesicle mediated transport	GO:0060627	139	0.035
phasic smooth muscle contraction	GO:0014821	8	0.034
response to extracellular stimulus	GO:0009991	127	0.034
positive regulation of leukocyte mediated immunity	GO:0002705	70	0.034
regulation of neuron death	GO:1901214	134	0.034
regulation of adaptive immune response based on somatic recombination of immune receptors built from immunoglobulin superfamily domains	GO:0002822	87	0.034
immunoglobulin mediated immune response	GO:0016064	69	0.034
protein catabolic process	GO:0030163	221	0.033
peptidyl serine modification	GO:0018209	83	0.033
positive regulation of protein kinase activity	GO:0045860	144	0.033
cell substrate adhesion	GO:0031589	130	0.033
negative regulation of homeostatic process	GO:0032845	71	0.033
leukocyte differentiation	GO:0002521	342	0.032
positive regulation of eosinophil migration	GO:2000418	2	0.032
regulation of peptidyl serine phosphorylation	GO:0033135	39	0.032
cellular metal ion homeostasis	GO:0006875	151	0.031
drug metabolic process	GO:0017144	4	0.031
positive regulation of kinase activity	GO:0033674	155	0.031
positive regulation of protein activation cascade	GO:2000259	2	0.031
response to acid chemical	GO:0001101	111	0.031
multicellular organism growth	GO:0035264	161	0.031
multicellular organismal homeostasis	GO:0048871	164	0.031
regulation of membrane potential	GO:0042391	192	0.031
negative regulation of protein phosphorylation	GO:0001933	126	0.031
regulation of angiotensin levels in blood	GO:0002002	4	0.030
regulation of proteolysis	GO:0030162	164	0.030	Mouse
peptide transport	GO:0015833	133	0.030
phagocytosis	GO:0006909	66	0.030
peptide secretion	GO:0002790	114	0.029
regulation of eosinophil migration	GO:2000416	2	0.029
regulation of cellular carbohydrate metabolic process	GO:0010675	75	0.029	Mouse
response to drug	GO:0042493	75	0.029
positive regulation of defense response	GO:0031349	124	0.029
cellular chemical homeostasis	GO:0055082	215	0.029
regulation of fat cell differentiation	GO:0045598	81	0.029
development of primary female sexual characteristics	GO:0046545	73	0.028
glucose metabolic process	GO:0006006	92	0.028	Mouse
positive regulation of lymphocyte differentiation	GO:0045621	61	0.028
cellular amine metabolic process	GO:0044106	44	0.028
reactive nitrogen species metabolic process	GO:2001057	0	0.028
regulation of hydrolase activity	GO:0051336	246	0.028	Mouse
organ regeneration	GO:0031100	2	0.027
nitrogen compound transport	GO:0071705	271	0.027
germ cell development	GO:0007281	185	0.027
metal ion homeostasis	GO:0055065	189	0.027
regulation of angiotensin metabolic process	GO:0060177	4	0.027
cellular divalent inorganic cation homeostasis	GO:0072503	127	0.027
defense response to gram positive bacterium	GO:0050830	50	0.027
regulation of immunoglobulin mediated immune response	GO:0002889	37	0.026
cell adhesion	GO:0007155	329	0.026
positive regulation of protein secretion	GO:0050714	52	0.026
granzyme mediated apoptotic signaling pathway	GO:0008626	1	0.026
neuron apoptotic process	GO:0051402	142	0.026
cellular response to lipid	GO:0071396	145	0.026
antibacterial peptide production	GO:0002778	2	0.025
phosphatidylinositol mediated signaling	GO:0048015	41	0.025	Mouse
protein kinase b signaling	GO:0043491	74	0.025
learning or memory	GO:0007611	148	0.025
lymphocyte activation involved in immune response	GO:0002285	93	0.025
nucleotide metabolic process	GO:0009117	332	0.025
regulation of cell cycle	GO:0051726	281	0.025
positive regulation of phospholipase c activity	GO:0010863	2	0.025
negative regulation of peptidase activity	GO:0010466	46	0.025	Mouse
epithelial cell proliferation	GO:0050673	174	0.025	Rat
regulation of cytokine secretion	GO:0050707	61	0.025
cellular homeostasis	GO:0019725	240	0.024
negative regulation of endopeptidase activity	GO:0010951	44	0.024	Mouse
regulation of lymphocyte activation	GO:0051249	240	0.024
neuron death	GO:0070997	154	0.024
regulation of t cell activation	GO:0050863	170	0.024
fat cell differentiation	GO:0045444	160	0.024
peptidyl tyrosine modification	GO:0018212	145	0.024
regulation of reactive oxygen species biosynthetic process	GO:1903426	2	0.024
regulation of cell migration	GO:0030334	219	0.024
negative regulation of cell proliferation	GO:0008285	296	0.024	Rat
regulation of metal ion transport	GO:0010959	106	0.024
antibacterial peptide biosynthetic process	GO:0002780	2	0.023
positive regulation of secretion by cell	GO:1903532	114	0.023
homeostasis of number of cells	GO:0048872	210	0.023
regulation of protein localization	GO:0032880	231	0.023
regulation of protein kinase b signaling	GO:0051896	56	0.023
regulation of complement activation	GO:0030449	7	0.023
response to organic cyclic compound	GO:0014070	198	0.023
regulation of cytokine production	GO:0001817	266	0.023
negative regulation of neuron apoptotic process	GO:0043524	92	0.023
t cell mediated immunity	GO:0002456	50	0.023
peristalsis	GO:0030432	8	0.022
negative regulation of execution phase of apoptosis	GO:1900118	4	0.022
regulation of t cell differentiation	GO:0045580	83	0.022
negative regulation of phospholipase activity	GO:0010519	4	0.022
nucleobase containing small molecule metabolic process	GO:0055086	352	0.022
negative regulation of hydrolase activity	GO:0051346	71	0.022	Mouse
regulation of blood vessel size by renin angiotensin	GO:0002034	5	0.022
negative regulation of growth	GO:0045926	99	0.022
blood vessel morphogenesis	GO:0048514	285	0.022	Rat
positive regulation of immune effector process	GO:0002699	107	0.021
negative regulation of lymphocyte activation	GO:0051250	91	0.021
negative regulation of phosphorus metabolic process	GO:0010563	184	0.021
female gamete generation	GO:0007292	74	0.021
glucose homeostasis	GO:0042593	128	0.021
feeding behavior	GO:0007631	62	0.021
stress activated protein kinase signaling cascade	GO:0031098	81	0.021
reactive oxygen species biosynthetic process	GO:1903409	8	0.020
oxidation reduction process	GO:0055114	342	0.020
regulation of cell motility	GO:2000145	236	0.020
cytokine mediated signaling pathway	GO:0019221	115	0.020
mesonephric tubule development	GO:0072164	94	0.020
organic cyclic compound catabolic process	GO:1901361	295	0.020
regulation of peptide transport	GO:0090087	91	0.020
endocrine process	GO:0050886	39	0.020
positive regulation of phospholipase activity	GO:0010518	3	0.020
regulation of establishment of protein localization	GO:0070201	181	0.020
negative regulation of cell activation	GO:0050866	111	0.020
positive regulation of thymocyte migration	GO:2000412	2	0.019
organonitrogen compound biosynthetic process	GO:1901566	192	0.019
cellular response to acid chemical	GO:0071229	68	0.019
positive regulation of lymphocyte mediated immunity	GO:0002708	62	0.019
negative regulation of complement activation	GO:0045916	3	0.019
lymphocyte differentiation	GO:0030098	242	0.019
extracellular structure organization	GO:0043062	148	0.019
calcium ion homeostasis	GO:0055074	127	0.019
regulation of endocytosis	GO:0030100	69	0.019
regulation of cell adhesion	GO:0030155	154	0.019
regulation of neuron apoptotic process	GO:0043523	122	0.019
fertilization	GO:0009566	127	0.019
negative regulation of protein modification process	GO:0031400	163	0.018
peptidyl tyrosine phosphorylation	GO:0018108	143	0.018
cellular response to organic cyclic compound	GO:0071407	87	0.018
divalent inorganic cation homeostasis	GO:0072507	138	0.018
leukocyte mediated cytotoxicity	GO:0001909	62	0.018
glycerolipid biosynthetic process	GO:0045017	50	0.018
purine containing compound catabolic process	GO:0072523	213	0.018
renal control of peripheral vascular resistance involved in regulation of systemic arterial blood pressure	GO:0003072	5	0.018
regulation of reactive oxygen species metabolic process	GO:2000377	40	0.018
humoral immune response	GO:0006959	57	0.018
ovulation cycle	GO:0042698	59	0.018
i kappab kinase nf kappab signaling	GO:0007249	85	0.018
transmission of nerve impulse	GO:0019226	76	0.017
regulation of b cell mediated immunity	GO:0002712	37	0.017
regulation of leukocyte mediated immunity	GO:0002703	104	0.017
angiogenesis	GO:0001525	201	0.017	Rat
anatomical structure homeostasis	GO:0060249	145	0.017
chemotaxis	GO:0006935	247	0.017
activation of adenylate cyclase activity	GO:0007190	4	0.017
thymocyte migration	GO:0072679	2	0.017
carbohydrate homeostasis	GO:0033500	128	0.017
lipid localization	GO:0010876	126	0.017
nephron epithelium development	GO:0072009	92	0.017
cellular response to food	GO:0071240	1	0.017
kidney epithelium development	GO:0072073	121	0.017
ovulation	GO:0030728	15	0.017
aromatic compound catabolic process	GO:0019439	286	0.017
regulation of steroid metabolic process	GO:0019218	39	0.017	Mouse
cognition	GO:0050890	149	0.017
negative regulation of mapk cascade	GO:0043409	65	0.017
astrocyte development	GO:0014002	12	0.016
transition metal ion transport	GO:0000041	38	0.016
small gtpase mediated signal transduction	GO:0007264	97	0.016
monocarboxylic acid biosynthetic process	GO:0072330	61	0.016
t cell activation	GO:0042110	289	0.016
exocytosis	GO:0006887	121	0.016
posttranscriptional regulation of gene expression	GO:0010608	155	0.016
lipid modification	GO:0030258	65	0.016
apoptotic signaling pathway	GO:0097190	306	0.016
regulation of cellular catabolic process	GO:0031329	242	0.016
negative regulation of insulin secretion involved in cellular response to glucose stimulus	GO:0061179	4	0.016
transmembrane transport	GO:0055085	412	0.016
heterocycle catabolic process	GO:0046700	280	0.016
positive regulation of lipid biosynthetic process	GO:0046889	18	0.016
cation homeostasis	GO:0055080	212	0.015
eosinophil migration	GO:0072677	3	0.015
spermatid differentiation	GO:0048515	115	0.015
ribonucleotide metabolic process	GO:0009259	291	0.015
transmembrane receptor protein serine threonine kinase signaling pathway	GO:0007178	194	0.015
regulation of acute inflammatory response	GO:0002673	27	0.015
cellular response to oxidative stress	GO:0034599	76	0.015
nucleic acid phosphodiester bond hydrolysis	GO:0090305	49	0.015
cellular calcium ion homeostasis	GO:0006874	119	0.015
response to osmotic stress	GO:0006970	21	0.015
mesonephric epithelium development	GO:0072163	94	0.015
regulation of immunoglobulin production	GO:0002637	42	0.015
cellular macromolecule catabolic process	GO:0044265	206	0.015
terpenoid metabolic process	GO:0006721	25	0.015
negative regulation of blood vessel morphogenesis	GO:2000181	25	0.015	Rat
negative regulation of phosphate metabolic process	GO:0045936	184	0.015
regulation of hemostasis	GO:1900046	28	0.015
spermatid development	GO:0007286	108	0.015
learning	GO:0007612	98	0.014
nucleoside phosphate metabolic process	GO:0006753	338	0.014
regulation of body fluid levels	GO:0050878	162	0.014
intracellular protein transport	GO:0006886	204	0.014
renal system development	GO:0072001	225	0.014
cellular response to growth factor stimulus	GO:0071363	197	0.014
extracellular matrix organization	GO:0030198	147	0.014
response to oxidative stress	GO:0006979	123	0.014
protein modification by small protein conjugation	GO:0032446	187	0.014
positive regulation of reactive oxygen species biosynthetic process	GO:1903428	2	0.014
negative regulation of proteolysis	GO:0045861	74	0.014	Mouse
protein localization to organelle	GO:0033365	185	0.014
purine ribonucleotide metabolic process	GO:0009150	290	0.014
disruption of cells of other organism involved in symbiotic interaction	GO:0051818	13	0.014
regulation of systemic arterial blood pressure by hormone	GO:0001990	25	0.014
cellular response to lipopolysaccharide	GO:0071222	77	0.014
positive regulation of apoptotic signaling pathway	GO:2001235	95	0.014
negative regulation of protein activation cascade	GO:2000258	3	0.014
t cell proliferation	GO:0042098	120	0.014
regulation of lipid storage	GO:0010883	20	0.014
locomotory behavior	GO:0007626	195	0.014
rhythmic process	GO:0048511	174	0.014
positive regulation of endocytosis	GO:0045807	42	0.014
immunoglobulin production	GO:0002377	73	0.014
nik nf kappab signaling	GO:0038061	14	0.013
hemostasis	GO:0007599	78	0.013
positive regulation of proteolysis	GO:0045862	85	0.013
regulation of blood coagulation	GO:0030193	28	0.013
olfactory learning	GO:0008355	2	0.013
organonitrogen compound catabolic process	GO:1901565	264	0.013
regulation of homeostatic process	GO:0032844	182	0.013
organophosphate biosynthetic process	GO:0090407	122	0.013
negative regulation of t cell activation	GO:0050868	65	0.013
forebrain development	GO:0030900	302	0.013
cytosolic calcium ion homeostasis	GO:0051480	70	0.013
regulation of intracellular transport	GO:0032386	159	0.013
myeloid cell homeostasis	GO:0002262	114	0.013
single organism cell adhesion	GO:0098602	156	0.013
dna metabolic process	GO:0006259	303	0.013
negative regulation of t cell proliferation	GO:0042130	38	0.013
morphogenesis of a branching structure	GO:0001763	203	0.013
regulation of tube size	GO:0035150	57	0.013
regulation of systemic arterial blood pressure mediated by a chemical signal	GO:0003044	33	0.013
negative regulation of kinase activity	GO:0033673	81	0.013
toll like receptor signaling pathway	GO:0002224	38	0.013
purine containing compound metabolic process	GO:0072521	311	0.013
activation of phospholipase c activity	GO:0007202	2	0.012
compound eye development	GO:0048749	1	0.012
single fertilization	GO:0007338	82	0.012
nephron development	GO:0072006	109	0.012
leukocyte apoptotic process	GO:0071887	71	0.012
positive regulation of t cell differentiation	GO:0045582	52	0.012
rna processing	GO:0006396	105	0.012
positive regulation of hydrolase activity	GO:0051345	148	0.012
purine ribonucleoside metabolic process	GO:0046128	241	0.012
vascular process in circulatory system	GO:0003018	62	0.012
response to nutrient levels	GO:0031667	109	0.012
regulation of transmembrane receptor protein serine threonine kinase signaling pathway	GO:0090092	112	0.012
sequestering of metal ion	GO:0051238	19	0.012
killing of cells in other organism involved in symbiotic interaction	GO:0051883	13	0.012
positive regulation of cell development	GO:0010720	237	0.012
asymmetric stem cell division	GO:0098722	3	0.012
regulation of systemic arterial blood pressure by renin angiotensin	GO:0003081	20	0.012
cellular response to transforming growth factor beta stimulus	GO:0071560	88	0.012
negative regulation of transmembrane receptor protein serine threonine kinase signaling pathway	GO:0090101	61	0.012
cellular ion homeostasis	GO:0006873	165	0.012
peptide hormone secretion	GO:0030072	109	0.012
regulation of cellular component biogenesis	GO:0044087	181	0.012
regulation of t cell proliferation	GO:0042129	92	0.012
progesterone metabolic process	GO:0042448	4	0.012
positive regulation of phagocytosis	GO:0050766	26	0.012
cytokine metabolic process	GO:0042107	71	0.011
regulation of map kinase activity	GO:0043405	120	0.011
myeloid cell differentiation	GO:0030099	233	0.011
immune response regulating signaling pathway	GO:0002764	125	0.011
killing of cells of other organism	GO:0031640	13	0.011
regulation of angiogenesis	GO:0045765	81	0.011	Rat
positive regulation of protein kinase b signaling	GO:0051897	32	0.011
leukocyte proliferation	GO:0070661	172	0.011
stress activated mapk cascade	GO:0051403	80	0.011
protein oligomerization	GO:0051259	67	0.011
regulation of lamellipodium assembly	GO:0010591	3	0.011
nephron epithelium morphogenesis	GO:0072088	68	0.011
negative regulation of response to wounding	GO:1903035	77	0.011
isoprenoid metabolic process	GO:0006720	29	0.011
regeneration	GO:0031099	38	0.011
negative regulation of cell growth	GO:0030308	44	0.011
cytoplasmic transport	GO:0016482	234	0.011
regulation of lymphocyte differentiation	GO:0045619	107	0.011
bone resorption	GO:0045453	38	0.011
negative regulation of angiogenesis	GO:0016525	25	0.011	Rat
purine nucleotide metabolic process	GO:0006163	302	0.011
cell activation involved in immune response	GO:0002263	126	0.011
renal tubule development	GO:0061326	87	0.011
phosphatidylinositol 3 kinase signaling	GO:0014065	36	0.011	Mouse
cell killing	GO:0001906	67	0.010
regulation of humoral immune response	GO:0002920	22	0.010
alpha beta t cell activation	GO:0046631	91	0.010
leukocyte chemotaxis	GO:0030595	69	0.010
negative regulation of leukocyte proliferation	GO:0070664	46	0.010
cytosolic calcium ion transport	GO:0060401	48	0.010
negative regulation of inflammatory response	GO:0050728	61	0.010
negative regulation of cellular response to growth factor stimulus	GO:0090288	46	0.010
regulation of phagocytosis	GO:0050764	33	0.010
cholesterol homeostasis	GO:0042632	44	0.010
cell chemotaxis	GO:0060326	81	0.010
regulation of cell growth involved in cardiac muscle cell development	GO:0061050	3	0.010
mitochondrion organization	GO:0007005	134	0.010
icosanoid metabolic process	GO:0006690	33	0.010
disruption by host of symbiont cells	GO:0051852	11	0.010
mesonephric tubule morphogenesis	GO:0072171	63	0.010
regulation of lymphocyte proliferation	GO:0050670	117	0.010
positive regulation of cytosolic calcium ion concentration	GO:0007204	65	0.010
regulation of leukocyte differentiation	GO:1902105	159	0.010
positive regulation of t cell activation	GO:0050870	101	0.010
epithelial cell development	GO:0002064	159	0.010
negative regulation of cell migration	GO:0030336	59	0.010
purine containing compound biosynthetic process	GO:0072522	70	0.010
positive regulation of leukocyte differentiation	GO:1902107	86	0.010
cellular response to molecule of bacterial origin	GO:0071219	83	0.010
organic hydroxy compound transport	GO:0015850	93	0.010
nephron morphogenesis	GO:0072028	69	0.010
regulation of protein catabolic process	GO:0042176	108	0.010

Serpina3c disease predictions

Disease predictions are made from cross-annotation of human disease genes to the identified functional analogs in mouse and predicted with the mouse functional network.

Disease	DO term ID	Probability
disease of metabolism	DOID:0014667	0.052
inherited metabolic disorder	DOID:655	0.014
disease of anatomical entity	DOID:7	0.011
nervous system disease	DOID:863	0.011

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