IMP: Integrative Multi-species Prediction

Mus musculus

0 known processes

Col6a3

collagen, type VI, alpha 3

(Aliases: Col6a-3,AI507288)

Entrez: 12835
Ensembl: ENSMUSG00000048126
UniProtKB: Q9Z0I9
UniProtKB: J3QQ16

Process Predictions
Disease Predictions

Col6a3 biological process predictions

Show only novel predictionsHighlight processes of functional analogs

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Biological process	GO term ID	Process size	Probability	Func Analog Org
extracellular structure organization	GO:0043062	148	0.998	Mouse
extracellular matrix organization	GO:0030198	147	0.977	Mouse
cellular response to amino acid stimulus	GO:0071230	29	0.899
cell adhesion	GO:0007155	329	0.842	Mouse
fibril organization	GO:0097435	2	0.649
collagen fibril organization	GO:0030199	32	0.560
bone development	GO:0060348	120	0.514
response to amino acid	GO:0043200	37	0.486
cellular response to growth factor stimulus	GO:0071363	197	0.468
extrinsic apoptotic signaling pathway	GO:0097191	126	0.457
cartilage condensation	GO:0001502	18	0.404
cell substrate adhesion	GO:0031589	130	0.395	Mouse
regulation of cell adhesion	GO:0030155	154	0.392	Mouse
response to growth factor	GO:0070848	198	0.386
cell aggregation	GO:0098743	18	0.382
skeletal system development	GO:0001501	356	0.374
nephron development	GO:0072006	109	0.372
regulation of cell substrate adhesion	GO:0010810	73	0.348	Mouse
ossification	GO:0001503	216	0.345
respiratory tube development	GO:0030323	167	0.333
aorta smooth muscle tissue morphogenesis	GO:0060414	2	0.325
cardiac muscle tissue development	GO:0048738	130	0.316
connective tissue development	GO:0061448	179	0.302
protein heterotrimerization	GO:0070208	8	0.287
cellular response to acid chemical	GO:0071229	68	0.274
extracellular fibril organization	GO:0043206	2	0.269
cell matrix adhesion	GO:0007160	68	0.266
negative regulation of cell adhesion	GO:0007162	45	0.257
trabecula formation	GO:0060343	24	0.242
blood vessel morphogenesis	GO:0048514	285	0.238
chondrocyte differentiation	GO:0002062	72	0.227
digestive system development	GO:0055123	200	0.221
regulation of neuron migration	GO:2001222	22	0.216
endoderm formation	GO:0001706	20	0.200
anatomical structure homeostasis	GO:0060249	145	0.198
wound healing	GO:0042060	157	0.189
male gamete generation	GO:0048232	285	0.189
proteoglycan metabolic process	GO:0006029	38	0.185
renal system development	GO:0072001	225	0.183
tissue homeostasis	GO:0001894	115	0.180
protein trimerization	GO:0070206	13	0.171
bone trabecula formation	GO:0060346	9	0.157
negative regulation of cell substrate adhesion	GO:0010812	16	0.152
physiological cardiac muscle hypertrophy	GO:0003301	3	0.148
endochondral bone morphogenesis	GO:0060350	50	0.142
urogenital system development	GO:0001655	261	0.139
cell type specific apoptotic process	GO:0097285	268	0.137
cellular response to transforming growth factor beta stimulus	GO:0071560	88	0.137
protein hydroxylation	GO:0018126	4	0.134
response to organonitrogen compound	GO:0010243	246	0.134
protein heterooligomerization	GO:0051291	14	0.133
negative regulation of cell development	GO:0010721	169	0.132
digestive tract development	GO:0048565	190	0.132
regulation of cell motility	GO:2000145	236	0.128
cartilage development involved in endochondral bone morphogenesis	GO:0060351	24	0.127
embryonic organ morphogenesis	GO:0048562	276	0.124
lung development	GO:0030324	164	0.124
cerebral cortex development	GO:0021987	86	0.122
striated muscle tissue development	GO:0014706	293	0.122
spermatogenesis	GO:0007283	284	0.121
response to bmp	GO:0071772	14	0.116
regulation of system process	GO:0044057	200	0.106
single organism cell adhesion	GO:0098602	156	0.106
face development	GO:0060324	38	0.104
cartilage development	GO:0051216	140	0.104
angiogenesis	GO:0001525	201	0.102
cardiac ventricle morphogenesis	GO:0003208	50	0.101
ventricular cardiac muscle tissue morphogenesis	GO:0055010	32	0.099
regulation of removal of superoxide radicals	GO:2000121	4	0.099
limb bud formation	GO:0060174	10	0.099
positive regulation of peptidase activity	GO:0010952	49	0.096
trabecula morphogenesis	GO:0061383	40	0.095
limb development	GO:0060173	166	0.093
heart morphogenesis	GO:0003007	178	0.093
muscle tissue morphogenesis	GO:0060415	53	0.092
removal of superoxide radicals	GO:0019430	12	0.090
limb morphogenesis	GO:0035108	149	0.088
cardiac muscle cell development	GO:0055013	39	0.086
response to organic cyclic compound	GO:0014070	198	0.085
skeletal system morphogenesis	GO:0048705	203	0.083
negative regulation of vasculature development	GO:1901343	26	0.083
digestive tract morphogenesis	GO:0048546	147	0.083
mesonephric tubule morphogenesis	GO:0072171	63	0.083
head morphogenesis	GO:0060323	34	0.081
multicellular organismal homeostasis	GO:0048871	164	0.080
cell growth involved in cardiac muscle cell development	GO:0061049	3	0.078
signal transduction in absence of ligand	GO:0038034	55	0.075
appendage morphogenesis	GO:0035107	149	0.075
intussusceptive angiogenesis	GO:0002041	2	0.073
embryonic skeletal system development	GO:0048706	120	0.072
cardiac chamber morphogenesis	GO:0003206	93	0.071
forebrain development	GO:0030900	302	0.071
negative regulation of nervous system development	GO:0051961	156	0.070
negative regulation of extrinsic apoptotic signaling pathway	GO:2001237	45	0.070
negative regulation of extrinsic apoptotic signaling pathway in absence of ligand	GO:2001240	16	0.068
cellular response to organonitrogen compound	GO:0071417	145	0.065
positive regulation of cell migration	GO:0030335	109	0.065
regulation of proteolysis	GO:0030162	164	0.064
elastic fiber assembly	GO:0048251	4	0.064
artery development	GO:0060840	53	0.064
regulation of cell growth involved in cardiac muscle cell development	GO:0061050	3	0.063
negative regulation of apoptotic signaling pathway	GO:2001234	104	0.062
regulation of extrinsic apoptotic signaling pathway in absence of ligand	GO:2001239	26	0.062
regulation of ossification	GO:0030278	112	0.062
ventricular cardiac muscle tissue development	GO:0003229	38	0.059
aorta development	GO:0035904	23	0.059
peripheral nervous system axon regeneration	GO:0014012	2	0.059
neuron migration	GO:0001764	122	0.057
positive regulation of cellular amino acid metabolic process	GO:0045764	3	0.057
synaptic transmission	GO:0007268	329	0.057
biomineral tissue development	GO:0031214	64	0.056
negative regulation of blood vessel morphogenesis	GO:2000181	25	0.056
regulation of extrinsic apoptotic signaling pathway	GO:2001236	77	0.055
negative regulation of tooth mineralization	GO:0070171	1	0.055
embryonic skeletal system morphogenesis	GO:0048704	91	0.054
small gtpase mediated signal transduction	GO:0007264	97	0.051
protein oligomerization	GO:0051259	67	0.051
bone morphogenesis	GO:0060349	78	0.050
regionalization	GO:0003002	337	0.050
negative regulation of angiogenesis	GO:0016525	25	0.050
muscle tissue development	GO:0060537	308	0.050
regulation of macrophage migration inhibitory factor signaling pathway	GO:2000446	1	0.049
regulation of synaptic growth at neuromuscular junction	GO:0008582	4	0.048
retinal blood vessel morphogenesis	GO:0061304	3	0.048
sensory perception of sound	GO:0007605	97	0.048	Mouse
formation of primary germ layer	GO:0001704	77	0.047
notochord development	GO:0030903	20	0.045
telencephalon development	GO:0021537	186	0.044
regulation of endothelial cell apoptotic process	GO:2000351	9	0.044
chondrocyte development	GO:0002063	24	0.044
negative regulation of phospholipase activity	GO:0010519	4	0.044
replacement ossification	GO:0036075	26	0.044
organ growth	GO:0035265	117	0.044
epithelial tube morphogenesis	GO:0060562	303	0.043
regulation of tooth mineralization	GO:0070170	2	0.043
camera type eye development	GO:0043010	266	0.042
negative regulation of neuron migration	GO:2001223	6	0.042
positive regulation of bone remodeling	GO:0046852	13	0.041
response to catecholamine	GO:0071869	4	0.041
cellular response to bmp stimulus	GO:0071773	14	0.039
glycoprotein metabolic process	GO:0009100	116	0.039
negative regulation of cell proliferation	GO:0008285	296	0.038
transforming growth factor beta receptor signaling pathway	GO:0007179	71	0.037
regulation of cell migration	GO:0030334	219	0.037
response to transforming growth factor beta	GO:0071559	88	0.037
endothelial cell apoptotic process	GO:0072577	9	0.037
cardiac muscle tissue morphogenesis	GO:0055008	44	0.037
regulation of apoptotic signaling pathway	GO:2001233	197	0.036
regulation of angiogenesis	GO:0045765	81	0.036
sensory organ morphogenesis	GO:0090596	242	0.036
astrocyte fate commitment	GO:0060018	4	0.036
branching morphogenesis of an epithelial tube	GO:0048754	159	0.035
bone trabecula morphogenesis	GO:0061430	12	0.035
kidney development	GO:0001822	213	0.034
rho protein signal transduction	GO:0007266	32	0.033
growth plate cartilage development	GO:0003417	14	0.033
ameboidal type cell migration	GO:0001667	128	0.033
endochondral bone growth	GO:0003416	19	0.033
gastrulation	GO:0007369	116	0.032
intestinal epithelial structure maintenance	GO:0060729	4	0.032
oviduct development	GO:0060066	3	0.032
endoderm development	GO:0007492	45	0.032
sensory perception	GO:0007600	245	0.032	Mouse
response to inorganic substance	GO:0010035	96	0.031
ras protein signal transduction	GO:0007265	77	0.031
regulation of muscle system process	GO:0090257	80	0.030
cardiac cell development	GO:0055006	41	0.030
pallium development	GO:0021543	120	0.030
cellular ketone metabolic process	GO:0042180	84	0.029
regulation of transmembrane receptor protein serine threonine kinase signaling pathway	GO:0090092	112	0.028
direct ossification	GO:0036072	5	0.028
clathrin coat assembly	GO:0048268	2	0.028
ear development	GO:0043583	200	0.028
regulation of biomineral tissue development	GO:0070167	33	0.027
cellular response to cytokine stimulus	GO:0071345	189	0.027
positive regulation of proteolysis	GO:0045862	85	0.027
skeletal muscle organ development	GO:0060538	163	0.027
physiological muscle hypertrophy	GO:0003298	3	0.026
regulation of transmission of nerve impulse	GO:0051969	1	0.026
cellular response to abiotic stimulus	GO:0071214	56	0.026
axonogenesis	GO:0007409	274	0.026
regulation of peptidase activity	GO:0052547	96	0.026
face morphogenesis	GO:0060325	29	0.026
tendon development	GO:0035989	6	0.025
positive regulation of cell motility	GO:2000147	116	0.025
developmental maturation	GO:0021700	193	0.025
organonitrogen compound biosynthetic process	GO:1901566	192	0.025
positive regulation of cell substrate adhesion	GO:0010811	47	0.025	Mouse
cellular response to superoxide	GO:0071451	14	0.025
mesenchyme development	GO:0060485	152	0.025
negative regulation of cell migration	GO:0030336	59	0.024
organelle fission	GO:0048285	170	0.024
peptidyl amino acid modification	GO:0018193	336	0.024
ear morphogenesis	GO:0042471	118	0.024
skin development	GO:0043588	220	0.024
negative regulation of gastrulation	GO:2000542	3	0.024
response to acid chemical	GO:0001101	111	0.023
extrinsic apoptotic signaling pathway in absence of ligand	GO:0097192	55	0.023
blood circulation	GO:0008015	195	0.023
regulation of neuron projection development	GO:0010975	169	0.022
sensory perception of mechanical stimulus	GO:0050954	107	0.022	Mouse
endodermal cell differentiation	GO:0035987	14	0.022
transmembrane receptor protein serine threonine kinase signaling pathway	GO:0007178	194	0.022
spinal cord development	GO:0021510	81	0.022
regulation of endodermal cell differentiation	GO:1903224	2	0.022
respiratory system development	GO:0060541	190	0.022
negative regulation of lipoprotein lipase activity	GO:0051005	1	0.022
macromolecule catabolic process	GO:0009057	281	0.022
extracellular matrix assembly	GO:0085029	12	0.021
regulation of chondrocyte differentiation	GO:0032330	33	0.021
positive regulation of cell morphogenesis involved in differentiation	GO:0010770	72	0.021
inner ear morphogenesis	GO:0042472	101	0.021
developmental cell growth	GO:0048588	84	0.021
cellular amino acid metabolic process	GO:0006520	103	0.020
response to thyroid hormone	GO:0097066	2	0.020
cellular response to mechanical stimulus	GO:0071260	7	0.020
muscle cell differentiation	GO:0042692	261	0.020
long term synaptic potentiation	GO:0060291	25	0.020
regulation of cartilage development	GO:0061035	44	0.020
otic vesicle development	GO:0071599	14	0.020
aorta morphogenesis	GO:0035909	22	0.020
positive regulation of growth	GO:0045927	104	0.020
negative regulation of cartilage development	GO:0061037	17	0.020
cellular response to external stimulus	GO:0071496	88	0.019
muscle cell development	GO:0055001	133	0.019
regulation of blood coagulation	GO:0030193	28	0.019
positive regulation of rho protein signal transduction	GO:0035025	7	0.019
kidney morphogenesis	GO:0060993	83	0.019
regulation of organelle organization	GO:0033043	289	0.019
positive regulation of hydrolase activity	GO:0051345	148	0.019
smooth muscle tissue development	GO:0048745	22	0.019
regulation of cellular amine metabolic process	GO:0033238	20	0.019
neuromuscular process	GO:0050905	99	0.019
negative regulation of signal transduction in absence of ligand	GO:1901099	16	0.018
regulation of rho protein signal transduction	GO:0035023	71	0.018
endomembrane system organization	GO:0010256	147	0.018
cellular response to epidermal growth factor stimulus	GO:0071364	4	0.018
response to epidermal growth factor	GO:0070849	4	0.018
regulation of cellular amino acid metabolic process	GO:0006521	5	0.018
positive regulation of metanephric mesenchymal cell migration	GO:2000591	1	0.017
regulation of homeostatic process	GO:0032844	182	0.017
negative regulation of macrophage chemotaxis	GO:0010760	1	0.017
appendage development	GO:0048736	166	0.017
positive regulation of cell adhesion	GO:0045785	80	0.017	Mouse
negative regulation of neuron projection regeneration	GO:0070571	3	0.017
plasma membrane organization	GO:0007009	90	0.016
oxidation reduction process	GO:0055114	342	0.016
multicellular organism growth	GO:0035264	161	0.016
mitotic cell cycle	GO:0000278	195	0.016
early endosome to late endosome transport	GO:0045022	2	0.016
foramen ovale closure	GO:0035922	1	0.016
homeostasis of number of cells	GO:0048872	210	0.016
bone resorption	GO:0045453	38	0.016
retina development in camera type eye	GO:0060041	119	0.016
regulation of sphingolipid biosynthetic process	GO:0090153	1	0.016
germ cell development	GO:0007281	185	0.015
peptidyl proline hydroxylation	GO:0019511	3	0.015
palate development	GO:0060021	76	0.015
cellular response to estradiol stimulus	GO:0071392	6	0.015
morphogenesis of a branching structure	GO:0001763	203	0.015
positive regulation of cellular amine metabolic process	GO:0033240	5	0.015
neuromuscular process controlling balance	GO:0050885	59	0.015
synaptic transmission cholinergic	GO:0007271	7	0.015
negative regulation of ossification	GO:0030279	49	0.015
regulation of vesicle mediated transport	GO:0060627	139	0.014
positive regulation of cell cycle	GO:0045787	92	0.014
nuclear division	GO:0000280	158	0.014
vegf activated neuropilin signaling pathway involved in axon guidance	GO:1902378	1	0.014
positive regulation of nervous system development	GO:0051962	221	0.014
response to radiation	GO:0009314	165	0.014
substrate adhesion dependent cell spreading	GO:0034446	30	0.014
regulation of muscle adaptation	GO:0043502	31	0.014
gland development	GO:0048732	330	0.014
positive regulation of axon extension	GO:0045773	20	0.014
positive regulation of cell projection organization	GO:0031346	95	0.013
cardiac chamber development	GO:0003205	108	0.013
negative regulation of intracellular signal transduction	GO:1902532	167	0.013
locomotory behavior	GO:0007626	195	0.013
organelle assembly	GO:0070925	177	0.013
negative regulation of response to wounding	GO:1903035	77	0.013
somitogenesis	GO:0001756	69	0.013
multi multicellular organism process	GO:0044706	109	0.013
negative regulation of cellular component organization	GO:0051129	194	0.013
cellular response to hormone stimulus	GO:0032870	150	0.013
defense response to bacterium	GO:0042742	119	0.013	Mouse
antimicrobial peptide secretion	GO:0002776	1	0.013
protein catabolic process	GO:0030163	221	0.013
odontogenesis	GO:0042476	78	0.013
covalent chromatin modification	GO:0016569	163	0.012
synaptic transmission glutamatergic	GO:0035249	36	0.012
regulation of cellular response to growth factor stimulus	GO:0090287	82	0.012
multicellular organismal response to stress	GO:0033555	62	0.012
negative regulation of immune system process	GO:0002683	209	0.012
regulation of ras protein signal transduction	GO:0046578	114	0.012
regulation of cellular component biogenesis	GO:0044087	181	0.012
regulation of exit from mitosis	GO:0007096	1	0.012
gonad development	GO:0008406	141	0.012
prostate gland morphogenesis	GO:0060512	32	0.012
negative regulation of epithelial cell proliferation	GO:0050680	64	0.012
salivary gland development	GO:0007431	37	0.012
cellular response to thyroid hormone stimulus	GO:0097067	1	0.012
anatomical structure maturation	GO:0071695	49	0.012
response to monoamine	GO:0071867	4	0.011
regulation of map kinase activity	GO:0043405	120	0.011
engulfment of apoptotic cell	GO:0043652	3	0.011
regulation of synaptic plasticity	GO:0048167	87	0.011
negative regulation of endodermal cell differentiation	GO:1903225	1	0.011
negative regulation of growth	GO:0045926	99	0.011
apoptotic signaling pathway	GO:0097190	306	0.011
cellular protein catabolic process	GO:0044257	155	0.011
regulation of cellular response to stress	GO:0080135	159	0.011
sequestering of bmp in extracellular matrix	GO:0035582	3	0.011
regulation of response to cytokine stimulus	GO:0060759	23	0.011
cytokine mediated signaling pathway	GO:0019221	115	0.011
metal ion homeostasis	GO:0055065	189	0.011
epithelial cell proliferation	GO:0050673	174	0.011
establishment of monopolar cell polarity	GO:0061162	8	0.011
positive regulation of cell development	GO:0010720	237	0.010
regulation of androgen receptor signaling pathway	GO:0060765	3	0.010
synapse organization	GO:0050808	125	0.010
positive regulation of transcription from rna polymerase ii promoter involved in smooth muscle cell differentiation	GO:2000721	2	0.010
negative regulation of cell motility	GO:2000146	61	0.010
glucose homeostasis	GO:0042593	128	0.010
reactive oxygen species metabolic process	GO:0072593	84	0.010

Col6a3 disease predictions

Disease predictions are made from cross-annotation of human disease genes to the identified functional analogs in mouse and predicted with the mouse functional network.

Disease	DO term ID	Probability	Func Analog Org
disease of anatomical entity	DOID:7	0.966	Human
musculoskeletal system disease	DOID:17	0.966	Human
myopathy	DOID:423	0.939	Human
muscular disease	DOID:0080000	0.939	Human
muscle tissue disease	DOID:66	0.939	Human
muscular dystrophy	DOID:9884	0.582	Human
congenital muscular dystrophy	DOID:0050557	0.582	Human
connective tissue disease	DOID:65	0.260
collagen disease	DOID:854	0.260
bone disease	DOID:0080001	0.132
bone remodeling disease	DOID:0080005	0.132
cardiomyopathy	DOID:0050700	0.071
heart disease	DOID:114	0.071
intrinsic cardiomyopathy	DOID:0060036	0.071
cardiovascular system disease	DOID:1287	0.071
dilated cardiomyopathy	DOID:12930	0.071
ehlers danlos syndrome	DOID:13359	0.069
bone development disease	DOID:0080006	0.051
osteogenesis imperfecta	DOID:12347	0.051
osteochondrodysplasia	DOID:2256	0.051
osteoporosis	DOID:11476	0.033
bone resorption disease	DOID:0080011	0.033
nervous system disease	DOID:863	0.028
eye disease	DOID:5614	0.023
sensory system disease	DOID:0050155	0.023
eye and adnexa disease	DOID:1492	0.023
retinal disease	DOID:5679	0.019
retinal degeneration	DOID:8466	0.017
glaucoma	DOID:1686	0.017

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