IMP: Integrative Multi-species Prediction

Mus musculus

0 known processes

Prl3d2

prolactin family 3, subfamily d, member 1

(Aliases: PL-Ib,Plib)

Ensembl: ENSMUSG00000062737
Entrez: 215028
UniProtKB: Q8CGZ8
UniProtKB: Q5SZY7

Process Predictions
Disease Predictions

Prl3d2 biological process predictions

Show only novel predictionsHighlight processes of functional analogs

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Biological process	GO term ID	Process size	Probability	Func Analog Org
negative regulation of blood vessel endothelial cell migration	GO:0043537	3	0.249	Mouse
negative regulation of endothelial cell migration	GO:0010596	4	0.164	Mouse
regulation of microvillus assembly	GO:0032534	3	0.138	Mouse
muscle fiber development	GO:0048747	76	0.062	Mouse
response to organic cyclic compound	GO:0014070	198	0.062
negative regulation of muscle cell differentiation	GO:0051148	33	0.055	Mouse
myotube differentiation	GO:0014902	105	0.052	Mouse
skeletal muscle fiber development	GO:0048741	58	0.047	Mouse
regulation of myotube differentiation	GO:0010830	62	0.045	Mouse
skeletal muscle organ development	GO:0060538	163	0.040	Mouse
hematopoietic progenitor cell differentiation	GO:0002244	143	0.037
regulation of skeletal muscle fiber development	GO:0048742	36	0.035	Mouse
muscle cell development	GO:0055001	133	0.033	Mouse
regulation of angiotensin metabolic process	GO:0060177	4	0.032
positive regulation of protein modification process	GO:0031401	299	0.032	Rat
regulation of response to wounding	GO:1903034	189	0.032
small gtpase mediated signal transduction	GO:0007264	97	0.031
muscle tissue development	GO:0060537	308	0.030	Mouse
regulation of microvillus organization	GO:0032530	3	0.030	Mouse
striated muscle cell development	GO:0055002	125	0.028	Mouse
response to testosterone	GO:0033574	3	0.028
positive regulation of cytokine production	GO:0001819	174	0.027
response to lipopolysaccharide	GO:0032496	128	0.027
immune effector process	GO:0002252	321	0.027
positive regulation of cell migration	GO:0030335	109	0.026	Mouse
muscle cell differentiation	GO:0042692	261	0.025	Mouse
blood circulation	GO:0008015	195	0.025
nucleoside triphosphate metabolic process	GO:0009141	230	0.025
maintenance of location	GO:0051235	89	0.025
adaptive immune response	GO:0002250	155	0.025
cell adhesion	GO:0007155	329	0.024
response to molecule of bacterial origin	GO:0002237	143	0.024
regulation of angiotensin levels in blood	GO:0002002	4	0.024
blood vessel morphogenesis	GO:0048514	285	0.023	Mouse
rho protein signal transduction	GO:0007266	32	0.023
positive regulation of protein kinase activity	GO:0045860	144	0.023	Rat
cellular homeostasis	GO:0019725	240	0.022
myotube cell development	GO:0014904	60	0.022	Mouse
blood vessel endothelial cell migration	GO:0043534	23	0.021	Mouse
cytokine production	GO:0001816	319	0.021
negative regulation of cell motility	GO:2000146	61	0.021	Mouse
positive regulation of protein phosphorylation	GO:0001934	242	0.021	Rat
cellular response to lipid	GO:0071396	145	0.021
leukocyte mediated immunity	GO:0002443	174	0.021
positive regulation of cell projection organization	GO:0031346	95	0.020	Mouse
positive regulation of cellular amine metabolic process	GO:0033240	5	0.020
regulation of cellular component biogenesis	GO:0044087	181	0.020	Mouse
ameboidal type cell migration	GO:0001667	128	0.020	Mouse
aromatic compound catabolic process	GO:0019439	286	0.020
mapk cascade	GO:0000165	281	0.020
regulation of cell motility	GO:2000145	236	0.019	Mouse
regulation of inflammatory response	GO:0050727	147	0.019
regulation of lymphocyte activation	GO:0051249	240	0.019
heterocycle catabolic process	GO:0046700	280	0.019
organic cyclic compound catabolic process	GO:1901361	295	0.019
regulation of muscle tissue development	GO:1901861	97	0.018	Mouse
regulation of cellular catabolic process	GO:0031329	242	0.018
positive regulation of kinase activity	GO:0033674	155	0.018	Rat
response to stilbenoid	GO:0035634	22	0.018
regulation of hormone levels	GO:0010817	211	0.018
myoblast differentiation	GO:0045445	52	0.018	Mouse
cellular nitrogen compound catabolic process	GO:0044270	280	0.017
cellular response to peptide hormone stimulus	GO:0071375	92	0.017
oxidation reduction process	GO:0055114	342	0.017
regulation of hydrolase activity	GO:0051336	246	0.017
positive regulation of cellular amino acid metabolic process	GO:0045764	3	0.017
regulation of cytokine production	GO:0001817	266	0.017
circulatory system process	GO:0003013	197	0.017
cellular chemical homeostasis	GO:0055082	215	0.017
macromolecule catabolic process	GO:0009057	281	0.017
regulation of cellular ketone metabolic process	GO:0010565	66	0.017
ras protein signal transduction	GO:0007265	77	0.017
regulation of cellular amino acid metabolic process	GO:0006521	5	0.017
protein maturation	GO:0051604	176	0.016
saturated monocarboxylic acid metabolic process	GO:0032788	2	0.016
monocarboxylic acid metabolic process	GO:0032787	191	0.016
nucleoside phosphate catabolic process	GO:1901292	222	0.016
regulation of cell migration	GO:0030334	219	0.016	Mouse
lymphocyte mediated immunity	GO:0002449	139	0.015
nucleoside phosphate metabolic process	GO:0006753	338	0.015
regulation of blood vessel endothelial cell migration	GO:0043535	12	0.015	Mouse
regulation of cell activation	GO:0050865	289	0.015
response to organonitrogen compound	GO:0010243	246	0.015
activation of janus kinase activity	GO:0042976	2	0.015	Rat
single organismal cell cell adhesion	GO:0016337	131	0.015
response to oxidative stress	GO:0006979	123	0.015
purine containing compound metabolic process	GO:0072521	311	0.015
sensory perception	GO:0007600	245	0.014
carbohydrate derivative catabolic process	GO:1901136	231	0.014
lipid biosynthetic process	GO:0008610	179	0.014
cellular amino acid metabolic process	GO:0006520	103	0.014
regulation of neural precursor cell proliferation	GO:2000177	70	0.014	Mouse
purine nucleotide metabolic process	GO:0006163	302	0.014
regulation of secretion	GO:0051046	274	0.014
positive regulation of thymocyte migration	GO:2000412	2	0.014
regulation of organelle organization	GO:0033043	289	0.014
cellular amine metabolic process	GO:0044106	44	0.014
glycoprotein biosynthetic process	GO:0009101	89	0.014
striated muscle tissue development	GO:0014706	293	0.014	Mouse
cellular ketone metabolic process	GO:0042180	84	0.014
t cell activation	GO:0042110	289	0.014
interspecies interaction between organisms	GO:0044419	83	0.014
protein processing	GO:0016485	163	0.013
cellular macromolecule catabolic process	GO:0044265	206	0.013
nucleobase containing small molecule metabolic process	GO:0055086	352	0.013
ribonucleoside metabolic process	GO:0009119	245	0.013
nitrogen compound transport	GO:0071705	271	0.013
wound healing	GO:0042060	157	0.013
cellular ion homeostasis	GO:0006873	165	0.013
purine nucleoside triphosphate catabolic process	GO:0009146	203	0.013
regulation of systemic arterial blood pressure mediated by a chemical signal	GO:0003044	33	0.013
ribose phosphate metabolic process	GO:0019693	291	0.013
hemostasis	GO:0007599	78	0.013
action potential	GO:0001508	78	0.013
regulation of defense response	GO:0031347	233	0.013
anatomical structure homeostasis	GO:0060249	145	0.013
endothelial cell migration	GO:0043542	44	0.013	Mouse
cellular divalent inorganic cation homeostasis	GO:0072503	127	0.012
positive regulation of cell motility	GO:2000147	116	0.012	Mouse
engulfment of apoptotic cell	GO:0043652	3	0.012
small molecule biosynthetic process	GO:0044283	132	0.012
purine ribonucleotide metabolic process	GO:0009150	290	0.012
purine ribonucleotide catabolic process	GO:0009154	208	0.012
regulation of body fluid levels	GO:0050878	162	0.012
regulation of cell adhesion	GO:0030155	154	0.012
cellular response to organonitrogen compound	GO:0071417	145	0.012
positive regulation of angiogenesis	GO:0045766	46	0.012	Mouse
response to steroid hormone	GO:0048545	56	0.012
transmission of nerve impulse	GO:0019226	76	0.012
anion transport	GO:0006820	177	0.012
regulation of striated muscle cell differentiation	GO:0051153	81	0.012	Mouse
ribonucleotide metabolic process	GO:0009259	291	0.012
protein catabolic process	GO:0030163	221	0.012
regulation of cell projection assembly	GO:0060491	38	0.012	Mouse
metal ion homeostasis	GO:0055065	189	0.012
nucleotide catabolic process	GO:0009166	217	0.012
regulation of transferase activity	GO:0051338	263	0.012	Rat
inflammatory response	GO:0006954	244	0.012
symbiosis encompassing mutualism through parasitism	GO:0044403	83	0.012
regulation of hemostasis	GO:1900046	28	0.012
heart morphogenesis	GO:0003007	178	0.012
purine ribonucleoside metabolic process	GO:0046128	241	0.012
regulation of blood pressure	GO:0008217	93	0.012
positive regulation of secretion by cell	GO:1903532	114	0.011
cellular response to testosterone stimulus	GO:0071394	1	0.011
regulation of protein localization	GO:0032880	231	0.011
innate immune response	GO:0045087	157	0.011
multicellular organismal homeostasis	GO:0048871	164	0.011
angiogenesis	GO:0001525	201	0.011	Mouse
nucleotide metabolic process	GO:0009117	332	0.011
activation of mapk activity involved in innate immune response	GO:0035419	2	0.011
t cell differentiation	GO:0030217	174	0.011
cellular lipid metabolic process	GO:0044255	323	0.011
purine nucleoside metabolic process	GO:0042278	241	0.011
regulation of lymphocyte differentiation	GO:0045619	107	0.011
positive regulation of transferase activity	GO:0051347	167	0.011	Rat
multicellular organismal signaling	GO:0035637	91	0.011
ribonucleotide catabolic process	GO:0009261	208	0.011
apoptotic signaling pathway	GO:0097190	306	0.011
cytokine metabolic process	GO:0042107	71	0.011
neuronal action potential	GO:0019228	54	0.011
negative regulation of angiogenesis	GO:0016525	25	0.011	Mouse
fatty acid metabolic process	GO:0006631	121	0.011
negative regulation of protein metabolic process	GO:0051248	282	0.011
organophosphate catabolic process	GO:0046434	232	0.011
negative regulation of hydrolase activity	GO:0051346	71	0.011
negative regulation of cell proliferation	GO:0008285	296	0.011
carbohydrate biosynthetic process	GO:0016051	74	0.010
inter male aggressive behavior	GO:0002121	3	0.010
positive regulation of cellular catabolic process	GO:0031331	148	0.010
negative regulation of molecular function	GO:0044092	258	0.010
purine ribonucleoside triphosphate metabolic process	GO:0009205	220	0.010
cellular response to hormone stimulus	GO:0032870	150	0.010
glycosyl compound metabolic process	GO:1901657	246	0.010
negative regulation of response to wounding	GO:1903035	77	0.010
cell type specific apoptotic process	GO:0097285	268	0.010
blood coagulation	GO:0007596	76	0.010
negative regulation of immune system process	GO:0002683	209	0.010
regulation of cellular amine metabolic process	GO:0033238	20	0.010
cofactor metabolic process	GO:0051186	80	0.010
carbohydrate metabolic process	GO:0005975	230	0.010
regulation of myoblast differentiation	GO:0045661	29	0.010	Mouse
antimicrobial peptide biosynthetic process	GO:0002777	2	0.010
sulfur compound metabolic process	GO:0006790	100	0.010
regulation of coagulation	GO:0050818	31	0.010

Prl3d2 disease predictions

Disease predictions are made from cross-annotation of human disease genes to the identified functional analogs in mouse and predicted with the mouse functional network.

Disease	DO term ID	Probability
disease of anatomical entity	DOID:7	0.023
nervous system disease	DOID:863	0.023
disease of metabolism	DOID:0014667	0.018
inherited metabolic disorder	DOID:655	0.018
eye disease	DOID:5614	0.016
sensory system disease	DOID:0050155	0.016
retinal disease	DOID:5679	0.016
eye and adnexa disease	DOID:1492	0.016
anemia	DOID:2355	0.014
hematopoietic system disease	DOID:74	0.014
normocytic anemia	DOID:720	0.014
immune system disease	DOID:2914	0.014
central nervous system disease	DOID:331	0.012
neurodegenerative disease	DOID:1289	0.012

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