IMP: Integrative Multi-species Prediction

Mus musculus

183 known processes

Igf1r

insulin-like growth factor I receptor

(Aliases: D930020L01,CD221,IGF-1R,A330103N21Rik,hyft)

Ensembl: ENSMUSG00000005533
Entrez: 16001
UniProtKB: Q60751
UniProtKB: E9QNX9
UniProtKB: Q3U1L4

Process Predictions
Disease Predictions

Igf1r biological process predictions

Show only novel predictionsHighlight processes of functional analogs

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Biological process	GO term ID	Process size	Probability	Func Analog Org
regulation of insulin receptor signaling pathway	GO:0046626	21	0.972
hexose metabolic process	GO:0019318	98	0.965	Mouse
monosaccharide metabolic process	GO:0005996	106	0.942	Mouse
regulation of polysaccharide metabolic process	GO:0032881	13	0.931	Mouse
regulation of glucan biosynthetic process	GO:0010962	7	0.925	Mouse
regulation of glycogen metabolic process	GO:0070873	13	0.878	Mouse
glucose metabolic process	GO:0006006	92	0.793	Mouse
glycogen metabolic process	GO:0005977	32	0.778	Mouse
cellular amino acid metabolic process	GO:0006520	103	0.768
positive regulation of glucose metabolic process	GO:0010907	21	0.755	Mouse
carbohydrate biosynthetic process	GO:0016051	74	0.732	Mouse
cellular polysaccharide metabolic process	GO:0044264	38	0.701	Mouse
sensory organ morphogenesis	GO:0090596	242	0.695	Zebrafish
generation of precursor metabolites and energy	GO:0006091	103	0.688	Mouse
regulation of t cell activation	GO:0050863	170	0.681
cellular carbohydrate metabolic process	GO:0044262	119	0.671	Mouse
insulin like growth factor receptor signaling pathway	GO:0048009	21	0.663	Human Zebrafish
negative regulation of insulin receptor signaling pathway	GO:0046627	14	0.659
regulation of cellular ketone metabolic process	GO:0010565	66	0.650
energy reserve metabolic process	GO:0006112	39	0.649	Mouse
gland development	GO:0048732	330	0.620
polysaccharide biosynthetic process	GO:0000271	20	0.619	Mouse
regulation of cellular amino acid metabolic process	GO:0006521	5	0.612
circadian rhythm	GO:0007623	114	0.612	Fly
epidermis development	GO:0008544	187	0.610
release of cytochrome c from mitochondria	GO:0001836	23	0.592
polysaccharide metabolic process	GO:0005976	39	0.575	Mouse
cellular amine metabolic process	GO:0044106	44	0.566
regulation of carbohydrate biosynthetic process	GO:0043255	40	0.534	Mouse
epithelial tube morphogenesis	GO:0060562	303	0.520
response to organic cyclic compound	GO:0014070	198	0.519	Rat Fly
amine metabolic process	GO:0009308	45	0.515
regulation of glucose metabolic process	GO:0010906	60	0.510	Mouse
leukocyte differentiation	GO:0002521	342	0.500
respiratory tube development	GO:0030323	167	0.488
cellular glucan metabolic process	GO:0006073	32	0.480	Mouse
insulin receptor signaling pathway	GO:0008286	49	0.480	Mouse Fly
cation transport	GO:0006812	399	0.472
regulation of cell migration	GO:0030334	219	0.467	Human
forebrain development	GO:0030900	302	0.461
transmembrane receptor protein tyrosine kinase signaling pathway	GO:0007169	247	0.455	Human Zebrafish Mouse Fly
multicellular organism growth	GO:0035264	161	0.454	Worm Fly
glycogen biosynthetic process	GO:0005978	14	0.453	Mouse
ossification	GO:0001503	216	0.445
oxidation reduction process	GO:0055114	342	0.433	Mouse
adult behavior	GO:0030534	135	0.426
myotube differentiation	GO:0014902	105	0.424	Fly
muscle tissue development	GO:0060537	308	0.412
negative regulation of glycogen biosynthetic process	GO:0045719	1	0.406
syncytium formation by plasma membrane fusion	GO:0000768	42	0.403	Fly
posttranscriptional regulation of gene expression	GO:0010608	155	0.399
negative regulation of release of cytochrome c from mitochondria	GO:0090201	6	0.395
central nervous system neuron differentiation	GO:0021953	162	0.386	Zebrafish
wound healing	GO:0042060	157	0.385	Zebrafish
gonad development	GO:0008406	141	0.374	Fly
single organismal cell cell adhesion	GO:0016337	131	0.370
glucan biosynthetic process	GO:0009250	14	0.369	Mouse
type i pneumocyte differentiation	GO:0060509	7	0.366
peptidyl amino acid modification	GO:0018193	336	0.364
carbohydrate metabolic process	GO:0005975	230	0.359	Mouse Fly
positive regulation of protein serine threonine kinase activity	GO:0071902	106	0.353	Human
regulation of generation of precursor metabolites and energy	GO:0043467	38	0.350	Mouse
sensory perception of umami taste	GO:0050917	4	0.341
response to alkaloid	GO:0043279	34	0.341	Fly
positive regulation of cellular amine metabolic process	GO:0033240	5	0.337
muscle cell differentiation	GO:0042692	261	0.335	Fly
positive regulation of map kinase activity	GO:0043406	84	0.329	Human
negative regulation of cell proliferation	GO:0008285	296	0.327
myelination in peripheral nervous system	GO:0022011	19	0.315
cellular macromolecule catabolic process	GO:0044265	206	0.313
skeletal system development	GO:0001501	356	0.311
establishment or maintenance of cell polarity	GO:0007163	86	0.302	Rat
translation	GO:0006412	93	0.301
negative regulation of intracellular signal transduction	GO:1902532	167	0.298
t cell activation	GO:0042110	289	0.296
proteasomal protein catabolic process	GO:0010498	98	0.295
regulation of cellular amine metabolic process	GO:0033238	20	0.293
lung epithelium development	GO:0060428	37	0.290
lung cell differentiation	GO:0060479	30	0.290
mesodermal cell migration	GO:0008078	4	0.285
urogenital system development	GO:0001655	261	0.285
synapse organization	GO:0050808	125	0.284
skin development	GO:0043588	220	0.283
regulation of release of cytochrome c from mitochondria	GO:0090199	11	0.279
t cell proliferation	GO:0042098	120	0.278
negative regulation of cellular response to insulin stimulus	GO:1900077	16	0.276
proteoglycan biosynthetic process	GO:0030166	20	0.274
modification dependent protein catabolic process	GO:0019941	133	0.269
mitotic cell cycle process	GO:1903047	159	0.267
regulation of binding	GO:0051098	111	0.266
regulation of leukocyte proliferation	GO:0070663	121	0.266
cellular response to peptide hormone stimulus	GO:0071375	92	0.264	Mouse Fly
ameboidal type cell migration	GO:0001667	128	0.263
positive regulation of cellular carbohydrate metabolic process	GO:0010676	29	0.261	Mouse
locomotory behavior	GO:0007626	195	0.261	Fly
multi multicellular organism process	GO:0044706	109	0.259	Fly
proteolysis involved in cellular protein catabolic process	GO:0051603	147	0.259
rhythmic process	GO:0048511	174	0.256	Fly
regulation of cellular catabolic process	GO:0031329	242	0.254	Worm Fly
negative regulation of cellular protein metabolic process	GO:0032269	247	0.250	Human Zebrafish
renal system development	GO:0072001	225	0.248
glucose transport	GO:0015758	56	0.242
connective tissue development	GO:0061448	179	0.242
regulation of cell motility	GO:2000145	236	0.239	Human
regulation of cell activation	GO:0050865	289	0.236
regulation of membrane potential	GO:0042391	192	0.233
organelle assembly	GO:0070925	177	0.232	Worm
retina development in camera type eye	GO:0060041	119	0.231
positive regulation of cell cycle	GO:0045787	92	0.231
regulation of organ growth	GO:0046620	61	0.229	Fly
striated muscle tissue development	GO:0014706	293	0.226
action potential	GO:0001508	78	0.226
digestive system development	GO:0055123	200	0.224
positive regulation of protein phosphorylation	GO:0001934	242	0.224	Human
cellular ketone metabolic process	GO:0042180	84	0.220
cellular response to insulin stimulus	GO:0032869	78	0.220	Mouse Fly
morphogenesis of a branching epithelium	GO:0061138	193	0.219
camera type eye development	GO:0043010	266	0.212	Zebrafish
cytoplasmic transport	GO:0016482	234	0.210	Worm
regulation of cytoplasmic transport	GO:1903649	112	0.210	Worm
cerebellar granule cell precursor proliferation	GO:0021930	10	0.208
positive regulation of cellular amino acid metabolic process	GO:0045764	3	0.208
respiratory system development	GO:0060541	190	0.208
neuronal action potential	GO:0019228	54	0.206
developmental maturation	GO:0021700	193	0.205	Fly
response to insulin	GO:0032868	100	0.205	Mouse Fly
cellular response to peptide	GO:1901653	92	0.202	Mouse Fly
response to radiation	GO:0009314	165	0.201
regulation of cellular carbohydrate metabolic process	GO:0010675	75	0.200	Mouse
positive regulation of nervous system development	GO:0051962	221	0.199
steroid metabolic process	GO:0008202	119	0.196	Rat
lung development	GO:0030324	164	0.195
kidney development	GO:0001822	213	0.193
regulation of carbohydrate metabolic process	GO:0006109	75	0.192	Mouse
negative regulation of phosphorus metabolic process	GO:0010563	184	0.192
germ line stem cell division	GO:0042078	2	0.192	Fly
negative regulation of cellular amino acid metabolic process	GO:0045763	0	0.190
organ growth	GO:0035265	117	0.190	Fly
regulation of protein catabolic process	GO:0042176	108	0.190
regulation of system process	GO:0044057	200	0.189
cartilage development	GO:0051216	140	0.189
response to endoplasmic reticulum stress	GO:0034976	53	0.188
response to nutrient levels	GO:0031667	109	0.186	Rat Worm
positive regulation of t cell activation	GO:0050870	101	0.185
regulation of steroid biosynthetic process	GO:0050810	26	0.185	Rat
type ii pneumocyte differentiation	GO:0060510	7	0.184
gliogenesis	GO:0042063	141	0.182
carbohydrate homeostasis	GO:0033500	128	0.182
glucose import	GO:0046323	32	0.180
positive regulation of protein kinase activity	GO:0045860	144	0.178	Human
immune effector process	GO:0002252	321	0.178
intracellular protein transport	GO:0006886	204	0.174	Worm
regulation of feeding behavior	GO:0060259	3	0.173	Fly
response to organonitrogen compound	GO:0010243	246	0.172	Mouse Fly
glucan metabolic process	GO:0044042	32	0.172	Mouse
positive regulation of insulin receptor signaling pathway	GO:0046628	4	0.170
positive regulation of cell activation	GO:0050867	158	0.169
regulation of secretion by cell	GO:1903530	249	0.169
response to peptide hormone	GO:0043434	127	0.167	Mouse Fly
positive regulation of lymphocyte proliferation	GO:0050671	70	0.166
regulation of nuclear division	GO:0051783	56	0.165
apoptotic mitochondrial changes	GO:0008637	48	0.165
fat cell differentiation	GO:0045444	160	0.165
negative regulation of phosphate metabolic process	GO:0045936	184	0.165
cellular lipid metabolic process	GO:0044255	323	0.163
glial cell differentiation	GO:0010001	131	0.162
cellular response to organonitrogen compound	GO:0071417	145	0.161	Mouse Fly
positive regulation of cell migration	GO:0030335	109	0.158	Human
activation of mapk activity	GO:0000187	59	0.157	Human
carbohydrate transport	GO:0008643	62	0.157
cellular response to abiotic stimulus	GO:0071214	56	0.155	Mouse
positive regulation of kinase activity	GO:0033674	155	0.154	Human
regulation of proteolysis	GO:0030162	164	0.153	Zebrafish
response to growth factor	GO:0070848	198	0.151	Mouse
positive regulation of cell motility	GO:2000147	116	0.151	Human
memory	GO:0007613	58	0.149
regulation of hormone levels	GO:0010817	211	0.149	Rat
hormone secretion	GO:0046879	128	0.148
embryonic limb morphogenesis	GO:0030326	126	0.147
motor neuron axon guidance	GO:0008045	26	0.147
protein kinase b signaling	GO:0043491	74	0.147
energy derivation by oxidation of organic compounds	GO:0015980	77	0.147	Mouse
regulation of synaptic growth at neuromuscular junction	GO:0008582	4	0.146
regulation of protein maturation	GO:1903317	96	0.146	Zebrafish
regulation of protein binding	GO:0043393	60	0.143
regulation of phospholipase c activity	GO:1900274	3	0.142
lipid transport	GO:0006869	98	0.142
t cell activation involved in immune response	GO:0002286	43	0.140
cell adhesion	GO:0007155	329	0.138
monosaccharide transport	GO:0015749	58	0.138
cell maturation	GO:0048469	127	0.138	Fly
lung epithelial cell differentiation	GO:0060487	29	0.137
protein heterotetramerization	GO:0051290	4	0.137
positive regulation of cellular catabolic process	GO:0031331	148	0.136
formation of radial glial scaffolds	GO:0021943	4	0.136
neuron projection guidance	GO:0097485	141	0.136	Fly
macromolecule catabolic process	GO:0009057	281	0.136
regulation of kinase activity	GO:0043549	249	0.135	Human
exocrine system development	GO:0035272	45	0.134
positive regulation of cell division	GO:0051781	31	0.134
cell proliferation in external granule layer	GO:0021924	10	0.133
aminoglycan metabolic process	GO:0006022	34	0.132
regulation of cellular component biogenesis	GO:0044087	181	0.132	Worm
nucleocytoplasmic transport	GO:0006913	139	0.132	Worm
positive regulation of lymphocyte activation	GO:0051251	140	0.131
cellular metal ion homeostasis	GO:0006875	151	0.131
chromatin organization	GO:0006325	206	0.131
neural tube closure	GO:0001843	90	0.130
stem cell differentiation	GO:0048863	268	0.129
leukocyte proliferation	GO:0070661	172	0.128
embryonic appendage morphogenesis	GO:0035113	126	0.128
positive regulation of leukocyte proliferation	GO:0070665	73	0.127
negative regulation of molecular function	GO:0044092	258	0.125
spermatogenesis	GO:0007283	284	0.125	Mouse Fly
circulatory system process	GO:0003013	197	0.124
negative regulation of translation	GO:0017148	22	0.123
axon guidance	GO:0007411	141	0.123	Fly
regulation of apoptotic signaling pathway	GO:2001233	197	0.122
regulation of bmp signaling pathway	GO:0030510	60	0.122
regulation of fat cell differentiation	GO:0045598	81	0.120
reactive nitrogen species metabolic process	GO:2001057	0	0.119
response to peptide	GO:1901652	136	0.119	Mouse Fly
positive regulation of transcription elongation from rna polymerase ii promoter	GO:0032968	2	0.118
hexose transport	GO:0008645	56	0.118
female sex differentiation	GO:0046660	84	0.117	Fly
endocytosis	GO:0006897	168	0.117
epithelial cell proliferation	GO:0050673	174	0.117
lipid catabolic process	GO:0016042	69	0.116
positive regulation of lipid metabolic process	GO:0045834	40	0.115	Rat
nucleotide metabolic process	GO:0009117	332	0.115
angiogenesis	GO:0001525	201	0.115
branching morphogenesis of an epithelial tube	GO:0048754	159	0.114
lipid localization	GO:0010876	126	0.114	Worm
regulation of anatomical structure size	GO:0090066	178	0.113	Fly
morphogenesis of a branching structure	GO:0001763	203	0.113
regulation of cell projection assembly	GO:0060491	38	0.110
modification dependent macromolecule catabolic process	GO:0043632	133	0.109
purine containing compound catabolic process	GO:0072523	213	0.108
myeloid cell differentiation	GO:0030099	233	0.106
regulation of gtp catabolic process	GO:0033124	113	0.106
regulation of proteasomal ubiquitin dependent protein catabolic process	GO:0032434	40	0.106
regulation of cell size	GO:0008361	72	0.106	Fly
regulation of epithelial cell proliferation	GO:0050678	141	0.105
negative regulation of growth	GO:0045926	99	0.105
positive regulation of interleukin 5 secretion	GO:2000664	1	0.104
photoreceptor cell development	GO:0042461	40	0.104
regulation of glucose transport	GO:0010827	32	0.104
hindbrain development	GO:0030902	128	0.104
regulation of mitochondrion organization	GO:0010821	27	0.103
clara cell differentiation	GO:0060486	4	0.103
germline stem cell asymmetric division	GO:0098728	2	0.103	Fly
hemostasis	GO:0007599	78	0.102
regulation of hydrolase activity	GO:0051336	246	0.102	Zebrafish
skeletal system morphogenesis	GO:0048705	203	0.101
axonogenesis	GO:0007409	274	0.101	Rat Fly
protein targeting	GO:0006605	143	0.101	Worm
epithelial cell development	GO:0002064	159	0.101	Mouse
positive regulation of lipid biosynthetic process	GO:0046889	18	0.100	Rat
embryonic skeletal system development	GO:0048706	120	0.100
regulation of cell cycle process	GO:0010564	160	0.099
regulation of glycogen biosynthetic process	GO:0005979	7	0.099	Mouse
mitotic cell cycle	GO:0000278	195	0.099
nuclear import	GO:0051170	95	0.099	Worm
cellular protein catabolic process	GO:0044257	155	0.098
negative regulation of cellular response to growth factor stimulus	GO:0090288	46	0.097
cell fate commitment	GO:0045165	210	0.097
positive regulation of phospholipase activity	GO:0010518	3	0.097
positive regulation of protein modification process	GO:0031401	299	0.096	Human
prostate gland development	GO:0030850	48	0.096
positive regulation of transferase activity	GO:0051347	167	0.096	Human
negative regulation of cellular amine metabolic process	GO:0033239	1	0.096
axon ensheathment	GO:0008366	76	0.095
apical constriction	GO:0003383	4	0.095
neural tube formation	GO:0001841	108	0.095
ear development	GO:0043583	200	0.094	Zebrafish
epithelial cell migration	GO:0010631	63	0.093
negative regulation of hydrolase activity	GO:0051346	71	0.093	Zebrafish
neural tube development	GO:0021915	160	0.093
defecation	GO:0030421	1	0.093
t cell differentiation	GO:0030217	174	0.092
negative regulation of synapse assembly	GO:0051964	3	0.092
positive regulation of phospholipase c activity	GO:0010863	2	0.092
regulation of protein targeting	GO:1903533	61	0.091	Worm
forebrain generation of neurons	GO:0021872	63	0.090
nitrogen compound transport	GO:0071705	271	0.090
cell proliferation in hindbrain	GO:0021534	10	0.090
male gamete generation	GO:0048232	285	0.090	Mouse Fly
ras protein signal transduction	GO:0007265	77	0.089
regulation of protein serine threonine kinase activity	GO:0071900	157	0.089	Human
multi organism reproductive behavior	GO:0044705	29	0.089	Fly
ensheathment of neurons	GO:0007272	76	0.089
schwann cell development	GO:0014044	22	0.088
positive regulation of purine nucleotide catabolic process	GO:0033123	88	0.088
regulation of protein import into nucleus	GO:0042306	52	0.087	Worm
positive regulation of hydrolase activity	GO:0051345	148	0.087
retina morphogenesis in camera type eye	GO:0060042	45	0.087
lipid biosynthetic process	GO:0008610	179	0.086	Rat
neuron maturation	GO:0042551	29	0.086	Fly
regulation of nucleotide metabolic process	GO:0006140	169	0.086
cognition	GO:0050890	149	0.086
regulation of reactive oxygen species biosynthetic process	GO:1903426	2	0.086
positive regulation of cell growth	GO:0030307	33	0.085	Fly
apoptotic signaling pathway	GO:0097190	306	0.084
regulation of polysaccharide biosynthetic process	GO:0032885	7	0.084	Mouse
regulation of organelle organization	GO:0033043	289	0.084
intracellular receptor signaling pathway	GO:0030522	74	0.084
purine containing compound metabolic process	GO:0072521	311	0.083
purine nucleotide metabolic process	GO:0006163	302	0.083
syncytium formation	GO:0006949	43	0.083	Fly
erk1 and erk2 cascade	GO:0070371	77	0.083	Mouse
molting cycle	GO:0042303	90	0.082
maintenance of location	GO:0051235	89	0.082	Worm
ribonucleoside catabolic process	GO:0042454	206	0.082
regulation of cell cycle	GO:0051726	281	0.082
regulation of mitotic cell cycle	GO:0007346	126	0.081
prostate gland morphogenesis	GO:0060512	32	0.081
nuclear transcribed mrna catabolic process deadenylation dependent decay	GO:0000288	12	0.081
nucleoside catabolic process	GO:0009164	206	0.081
compound eye development	GO:0048749	1	0.080
negative regulation of epithelial cell proliferation	GO:0050680	64	0.080
negative regulation of proteolysis	GO:0045861	74	0.080	Zebrafish
cation homeostasis	GO:0055080	212	0.080
response to pain	GO:0048265	26	0.080
peptidyl tyrosine phosphorylation	GO:0018108	143	0.079
lymphocyte differentiation	GO:0030098	242	0.078
cellular nitrogen compound catabolic process	GO:0044270	280	0.078
nucleoside triphosphate catabolic process	GO:0009143	205	0.078
negative regulation of planar cell polarity pathway involved in pericardium morphogenesis	GO:2000166	1	0.077
eye photoreceptor cell differentiation	GO:0001754	41	0.077
leukocyte activation involved in immune response	GO:0002366	126	0.077
gtp metabolic process	GO:0046039	144	0.077
organic hydroxy compound transport	GO:0015850	93	0.077
plasma membrane long chain fatty acid transport	GO:0015911	1	0.076
regulation of transferase activity	GO:0051338	263	0.076	Human
negative regulation of mapk cascade	GO:0043409	65	0.076
wnt signaling pathway	GO:0016055	188	0.076
regulation of cellular response to insulin stimulus	GO:1900076	30	0.076
nucleoside phosphate metabolic process	GO:0006753	338	0.075
mitotic nuclear division	GO:0007067	48	0.075
cellular response to hormone stimulus	GO:0032870	150	0.075	Mouse Fly
filopodium assembly	GO:0046847	19	0.075
negative regulation of protein metabolic process	GO:0051248	282	0.074	Human Zebrafish
regulation of lipid metabolic process	GO:0019216	118	0.074	Rat
regulation of protein kinase activity	GO:0045859	232	0.074	Human
cellular response to growth factor stimulus	GO:0071363	197	0.073	Mouse
regulation of lymphocyte activation	GO:0051249	240	0.073
ribose phosphate biosynthetic process	GO:0046390	59	0.073
nucleobase containing small molecule metabolic process	GO:0055086	352	0.072
mapk cascade	GO:0000165	281	0.072
synaptic transmission	GO:0007268	329	0.072
regulation of peptidyl tyrosine phosphorylation	GO:0050730	93	0.072
heterocycle catabolic process	GO:0046700	280	0.072
negative regulation of endothelial cell migration	GO:0010596	4	0.071
anion transport	GO:0006820	177	0.071	Mouse
sulfur compound biosynthetic process	GO:0044272	37	0.071
neuron migration	GO:0001764	122	0.071
dna metabolic process	GO:0006259	303	0.071	Human Rat
guanosine containing compound metabolic process	GO:1901068	144	0.071
regulation of cellular protein catabolic process	GO:1903362	61	0.071
multicellular organismal signaling	GO:0035637	91	0.071
regulation of protein complex assembly	GO:0043254	83	0.071
primary neural tube formation	GO:0014020	95	0.070
establishment of protein localization to organelle	GO:0072594	118	0.069	Worm
regulation of sequence specific dna binding transcription factor activity	GO:0051090	106	0.069
positive regulation of apoptotic signaling pathway	GO:2001235	95	0.068
regulation of wnt signaling pathway	GO:0030111	123	0.068
actin cytoskeleton organization	GO:0030036	220	0.068
regulation of purine nucleotide metabolic process	GO:1900542	169	0.068
appendage morphogenesis	GO:0035107	149	0.067
hair cycle	GO:0042633	90	0.067
regulation of ion transport	GO:0043269	215	0.067	Mouse
regulation of transmembrane receptor protein serine threonine kinase signaling pathway	GO:0090092	112	0.067
protein localization to nucleus	GO:0034504	121	0.067	Worm
single organism cell adhesion	GO:0098602	156	0.066
regulation of mapk cascade	GO:0043408	248	0.065
regulation of melanocyte differentiation	GO:0045634	7	0.065
learning or memory	GO:0007611	148	0.065
lung alveolus development	GO:0048286	45	0.065
nuclear transport	GO:0051169	139	0.064	Worm
response to alcohol	GO:0097305	48	0.063
positive regulation of leukocyte differentiation	GO:1902107	86	0.063
negative regulation of mitochondrion organization	GO:0010823	9	0.063
central nervous system neuron development	GO:0021954	67	0.063
positive regulation of proteolysis involved in cellular protein catabolic process	GO:1903052	31	0.063
fatty acid transmembrane transport	GO:1902001	1	0.063
response to light stimulus	GO:0009416	135	0.063
muscle adaptation	GO:0043500	39	0.063
fibroblast proliferation	GO:0048144	35	0.062
organic cyclic compound catabolic process	GO:1901361	295	0.062
positive regulation of intracellular transport	GO:0032388	70	0.062
regulation of glucose import	GO:0046324	26	0.061
methylation	GO:0032259	134	0.061
neuroblast differentiation	GO:0014016	2	0.061
divalent metal ion transport	GO:0070838	172	0.061
protein import into nucleus	GO:0006606	95	0.061	Worm
retinal cone cell development	GO:0046549	8	0.061
peptidyl tyrosine modification	GO:0018212	145	0.060
somitogenesis	GO:0001756	69	0.060
hindlimb morphogenesis	GO:0035137	42	0.060
prostate glandular acinus morphogenesis	GO:0060526	7	0.060
regionalization	GO:0003002	337	0.060	Zebrafish
peptide secretion	GO:0002790	114	0.060
regulation of secretion	GO:0051046	274	0.060
mammary gland epithelium development	GO:0061180	65	0.060
axis elongation involved in somitogenesis	GO:0090245	4	0.060
central nervous system projection neuron axonogenesis	GO:0021952	21	0.059
neuron projection regeneration	GO:0031102	14	0.059
g protein coupled receptor signaling pathway	GO:0007186	243	0.059
cardiac right atrium morphogenesis	GO:0003213	3	0.059
inorganic ion transmembrane transport	GO:0098660	234	0.059
calcium ion homeostasis	GO:0055074	127	0.059
reactive oxygen species biosynthetic process	GO:1903409	8	0.058
regulation of proteolysis involved in cellular protein catabolic process	GO:1903050	56	0.058
regulation of filopodium assembly	GO:0051489	13	0.058
calcium ion transport	GO:0006816	159	0.057
lung lobe morphogenesis	GO:0060463	9	0.057
glial cell development	GO:0021782	54	0.057
positive regulation of dna templated transcription elongation	GO:0032786	2	0.057
transmembrane transport	GO:0055085	412	0.057
lipid storage	GO:0019915	36	0.056	Worm
negative regulation of apoptotic signaling pathway	GO:2001234	104	0.056
purine ribonucleoside metabolic process	GO:0046128	241	0.056
negative regulation of protein processing	GO:0010955	79	0.056	Zebrafish
glycoprotein metabolic process	GO:0009100	116	0.056
positive regulation of gtp catabolic process	GO:0033126	85	0.056
interleukin 5 secretion	GO:0072603	2	0.055
purine ribonucleotide metabolic process	GO:0009150	290	0.055
lymphocyte proliferation	GO:0046651	164	0.055
negative regulation of protein modification process	GO:0031400	163	0.055	Human
adult locomotory behavior	GO:0008344	91	0.055
bmp signaling pathway	GO:0030509	93	0.055
pancreas development	GO:0031016	57	0.055
appendage development	GO:0048736	166	0.054
ribonucleoprotein complex subunit organization	GO:0071826	28	0.054
negative regulation of nervous system development	GO:0051961	156	0.054
embryonic organ morphogenesis	GO:0048562	276	0.054	Zebrafish
dna methylation	GO:0006306	43	0.054
cellular response to cytokine stimulus	GO:0071345	189	0.053
regulation of map kinase activity	GO:0043405	120	0.053	Human
lymphocyte activation involved in immune response	GO:0002285	93	0.053
peptide transport	GO:0015833	133	0.053
regulation of body fluid levels	GO:0050878	162	0.053
protein alkylation	GO:0008213	81	0.053
regulation of mesenchymal cell proliferation involved in lung development	GO:2000790	2	0.053
receptor mediated endocytosis	GO:0006898	51	0.053
positive regulation of growth	GO:0045927	104	0.052	Worm Fly
proteoglycan metabolic process	GO:0006029	38	0.052
protein maturation	GO:0051604	176	0.052	Zebrafish
regulation of protein transport	GO:0051223	163	0.052	Worm
regulation of cerebellar granule cell precursor proliferation	GO:0021936	12	0.052
protein catabolic process	GO:0030163	221	0.052
organelle fission	GO:0048285	170	0.052
olfactory learning	GO:0008355	2	0.051
g protein coupled acetylcholine receptor signaling pathway	GO:0007213	4	0.051
regulation of hormone secretion	GO:0046883	88	0.051
forebrain neuron differentiation	GO:0021879	52	0.051
proteasome mediated ubiquitin dependent protein catabolic process	GO:0043161	88	0.051
regulation of cell shape	GO:0008360	39	0.051
cerebellum morphogenesis	GO:0021587	42	0.051
cytosolic calcium ion homeostasis	GO:0051480	70	0.051
cell differentiation in hindbrain	GO:0021533	24	0.051
cellular calcium ion homeostasis	GO:0006874	119	0.051
digestive tract development	GO:0048565	190	0.051
reproductive behavior	GO:0019098	32	0.050	Fly
activation of adenylate cyclase activity	GO:0007190	4	0.050
carbohydrate derivative biosynthetic process	GO:1901137	183	0.050
extrinsic apoptotic signaling pathway in absence of ligand	GO:0097192	55	0.050
inorganic cation transmembrane transport	GO:0098662	207	0.050
myeloid leukocyte differentiation	GO:0002573	119	0.050
regulation of cellular response to growth factor stimulus	GO:0090287	82	0.050
protein import	GO:0017038	101	0.050	Worm
regulation of peptide hormone secretion	GO:0090276	75	0.050
negative regulation of transmembrane receptor protein serine threonine kinase signaling pathway	GO:0090101	61	0.049
positive regulation of steroid biosynthetic process	GO:0010893	4	0.049	Rat
positive regulation of interleukin 13 secretion	GO:2000667	1	0.049
positive regulation of protein catabolic process	GO:0045732	60	0.049
substrate dependent cerebral cortex tangential migration	GO:0021825	3	0.049
peptide hormone secretion	GO:0030072	109	0.049
positive regulation of gtpase activity	GO:0043547	85	0.049
negative regulation of phosphorylation	GO:0042326	166	0.049
carbohydrate derivative catabolic process	GO:1901136	231	0.048
regulation of steroid metabolic process	GO:0019218	39	0.048	Rat
microtubule based process	GO:0007017	236	0.048
sensory system development	GO:0048880	3	0.048
blood circulation	GO:0008015	195	0.048
germ cell development	GO:0007281	185	0.048	Fly
muscle system process	GO:0003012	141	0.048
regulation of vesicle mediated transport	GO:0060627	139	0.048
purine nucleoside metabolic process	GO:0042278	241	0.048

Igf1r disease predictions

Disease predictions are made from cross-annotation of human disease genes to the identified functional analogs in mouse and predicted with the mouse functional network.

Disease	DO term ID	Probability
disease of cellular proliferation	DOID:14566	0.825
cancer	DOID:162	0.652
organ system cancer	DOID:0050686	0.358
disease of metabolism	DOID:0014667	0.132
gastrointestinal system cancer	DOID:3119	0.090
inherited metabolic disorder	DOID:655	0.080
acquired metabolic disease	DOID:0060158	0.057

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