Mus musculus

0 known processes

Pnpla8

patatin-like phospholipase domain containing 8

(Aliases: 1200006O19Rik,AI467579,MGC150064,Ipla2(gamma))

Pnpla8 biological process predictions


Filter by process size:
Biological processGO term IDProcess sizeProbabilityFunc Analog Org
regulation of cellular catabolic processGO:00313292420.151
establishment of protein localization to peroxisomeGO:007266340.136
cellular amino acid metabolic processGO:00065201030.119
guanosine containing compound metabolic processGO:19010681440.112
organic cyclic compound catabolic processGO:19013612950.105
protein localization to peroxisomeGO:007266240.100
nucleotide metabolic processGO:00091173320.093
nucleobase containing small molecule metabolic processGO:00550863520.081
cellular ketone metabolic processGO:0042180840.079
small gtpase mediated signal transductionGO:0007264970.077
glycosyl compound metabolic processGO:19016572460.076
ribonucleoside catabolic processGO:00424542060.076
protein catabolic processGO:00301632210.075
response to oxidative stressGO:00069791230.074
ras protein signal transductionGO:0007265770.072
ribose phosphate metabolic processGO:00196932910.068
ribonucleoside triphosphate catabolic processGO:00092031990.067
purine ribonucleoside metabolic processGO:00461282410.066
peroxisome organizationGO:000703170.063
nucleoside phosphate metabolic processGO:00067533380.062
ribonucleoside triphosphate metabolic processGO:00091992200.062
cellular macromolecule catabolic processGO:00442652060.059
ribonucleotide metabolic processGO:00092592910.058
aromatic compound catabolic processGO:00194392860.057
glycerophospholipid metabolic processGO:0006650710.056
Human
purine ribonucleotide catabolic processGO:00091542080.055
regulation of cellular response to stressGO:00801351590.055
ribonucleotide catabolic processGO:00092612080.053
negative regulation of protein metabolic processGO:00512482820.052
purine ribonucleoside catabolic processGO:00461302050.050
organonitrogen compound catabolic processGO:19015652640.050
Human
ribonucleoside metabolic processGO:00091192450.049
regulation of cellular ketone metabolic processGO:0010565660.048
peroxisomal transportGO:004357440.048
guanosine containing compound catabolic processGO:19010691440.048
negative regulation of cellular component organizationGO:00511291940.048
anion transportGO:00068201770.046
Human
carboxylic acid catabolic processGO:0046395510.046
response to nutrient levelsGO:00316671090.045
cellular protein catabolic processGO:00442571550.044
amine metabolic processGO:0009308450.044
Human
heterocycle catabolic processGO:00467002800.043
purine nucleoside triphosphate catabolic processGO:00091462030.042
cellular response to organonitrogen compoundGO:00714171450.042
cellular nitrogen compound catabolic processGO:00442702800.042
negative regulation of intracellular signal transductionGO:19025321670.041
nucleoside triphosphate metabolic processGO:00091412300.040
response to radiationGO:00093141650.040
organic anion transportGO:00157111370.040
Human
ubiquitin dependent protein catabolic process via the multivesicular body sorting pathwayGO:004316230.039
autophagyGO:0006914450.039
organic hydroxy compound metabolic processGO:19016152030.038
Human
purine ribonucleotide metabolic processGO:00091502900.038
macromolecule catabolic processGO:00090572810.037
nucleoside metabolic processGO:00091162460.037
proteolysis involved in cellular protein catabolic processGO:00516031470.036
negative regulation of phosphorus metabolic processGO:00105631840.036
purine containing compound catabolic processGO:00725232130.035
chromosome organization involved in meiosisGO:0070192390.035
purine ribonucleoside triphosphate catabolic processGO:00092071990.035
membrane organizationGO:00610242450.034
organophosphate catabolic processGO:00464342320.034
Human
purine nucleoside triphosphate metabolic processGO:00091442260.034
small molecule biosynthetic processGO:00442831320.034
Human
intracellular protein transportGO:00068862040.033
protein targetingGO:00066051430.033
negative regulation of cellular protein metabolic processGO:00322692470.033
nitrogen compound transportGO:00717052710.033
wnt signaling pathwayGO:00160551880.032
oxidation reduction processGO:00551143420.032
action potentialGO:0001508780.031
spermatogenesisGO:00072832840.031
gtp metabolic processGO:00460391440.031
organic acid biosynthetic processGO:0016053860.031
Human
multicellular organism growthGO:00352641610.031
cellular response to hormone stimulusGO:00328701500.031
positive regulation of cellular amino acid metabolic processGO:004576430.031
lipid biosynthetic processGO:00086101790.031
Human
protein targeting to peroxisomeGO:000662540.030
purine nucleoside metabolic processGO:00422782410.030
protein ubiquitinationGO:00165671710.030
response to light stimulusGO:00094161350.030
regulation of organelle organizationGO:00330432890.030
carbohydrate derivative catabolic processGO:19011362310.029
translationGO:0006412930.029
mitochondrion organizationGO:00070051340.029
regulation of purine nucleotide metabolic processGO:19005421690.029
fatty acid metabolic processGO:00066311210.029
Human
purine nucleotide metabolic processGO:00061633020.028
negative regulation of phosphate metabolic processGO:00459361840.028
regulation of neuron projection developmentGO:00109751690.028
posttranscriptional regulation of gene expressionGO:00106081550.028
cofactor metabolic processGO:0051186800.028
transmembrane transportGO:00550854120.028
regulation of neuron differentiationGO:00456642810.028
cell type specific apoptotic processGO:00972852680.028
negative regulation of immune system processGO:00026832090.028
response to organonitrogen compoundGO:00102432460.027
nucleoside catabolic processGO:00091642060.027
regulation of cellular amine metabolic processGO:0033238200.027
i kappab kinase nf kappab signalingGO:0007249850.027
rho protein signal transductionGO:0007266320.027
organelle fissionGO:00482851700.027
response to starvationGO:0042594650.027
purine containing compound metabolic processGO:00725213110.026
nucleoside phosphate catabolic processGO:19012922220.026
regulation of cellular component biogenesisGO:00440871810.026
reactive oxygen species metabolic processGO:0072593840.026
regulation of purine nucleotide catabolic processGO:00331211220.026
regulation of lipid metabolic processGO:00192161180.026
meiotic cell cycle processGO:1903046770.026
small molecule catabolic processGO:0044282710.026
Human
axonogenesisGO:00074092740.026
meiotic cell cycleGO:00513211220.026
nucleotide catabolic processGO:00091662170.026
transmembrane receptor protein serine threonine kinase signaling pathwayGO:00071781940.026
nuclear divisionGO:00002801580.026
sterol metabolic processGO:0016125580.026
meiotic nuclear divisionGO:00071261150.025
golgi to endosome transportGO:000689530.025
establishment of protein localization to organelleGO:00725941180.025
activation of immune responseGO:00022531380.025
purine ribonucleoside triphosphate metabolic processGO:00092052200.024
germ cell developmentGO:00072811850.024
proteasome mediated ubiquitin dependent protein catabolic processGO:0043161880.024
cell growthGO:00160491300.024
regulation of nucleotide catabolic processGO:00308111220.024
purine nucleoside catabolic processGO:00061522050.024
regulation of membrane potentialGO:00423911920.024
cation transportGO:00068123990.023
regulation of transferase activityGO:00513382630.023
cellular amine metabolic processGO:0044106440.023
Human
regulation of nucleotide metabolic processGO:00061401690.023
synapsisGO:0007129340.023
phospholipid metabolic processGO:0006644870.023
Human
regulation of nucleoside metabolic processGO:00091181300.023
negative regulation of protein modification processGO:00314001630.023
positive regulation of cellular amine metabolic processGO:003324050.023
regulation of ras gtpase activityGO:0032318880.023
establishment of protein localization to vacuoleGO:007266640.023
dendrite developmentGO:00163581150.022
steroid metabolic processGO:00082021190.022
response to inorganic substanceGO:0010035960.022
regulation of defense responseGO:00313472330.022
canonical wnt signaling pathwayGO:00600701300.022
nucleoside triphosphate catabolic processGO:00091432050.022
positive regulation of ras gtpase activityGO:0032320650.022
regulation of cellular amino acid metabolic processGO:000652150.022
regulation of intrinsic apoptotic signaling pathwayGO:2001242610.021
lipid localizationGO:00108761260.021
Human
protein localization to organelleGO:00333651850.021
regulation of cell projection organizationGO:00313442060.021
organophosphate biosynthetic processGO:00904071220.021
positive regulation of nucleotide catabolic processGO:0030813880.021
mitotic cell cycle processGO:19030471590.021
synapse organizationGO:00508081250.021
cellular response to growth factor stimulusGO:00713631970.021
response to peptide hormoneGO:00434341270.021
defense response to other organismGO:00985421970.020
forebrain developmentGO:00309003020.020
microtubule based processGO:00070172360.020
organelle localizationGO:00516401790.020
response to extracellular stimulusGO:00099911270.020
regulation of anatomical structure sizeGO:00900661780.020
positive regulation of cell motilityGO:20001471160.020
positive regulation of protein modification processGO:00314012990.020
synaptonemal complex organizationGO:0070193150.019
mapk cascadeGO:00001652810.019
protein modification by small protein conjugation or removalGO:00706472070.019
t cell activationGO:00421102890.019
female gamete generationGO:0007292740.019
monocarboxylic acid metabolic processGO:00327871910.019
Human
alcohol biosynthetic processGO:0046165430.019
positive regulation of purine nucleotide catabolic processGO:0033123880.019
multicellular organismal signalingGO:0035637910.019
purine nucleotide catabolic processGO:00061952110.019
cellular homeostasisGO:00197252400.018
mitochondrion degradationGO:000042230.018
response to peptideGO:19016521360.018
camera type eye developmentGO:00430102660.018
negative regulation of phosphorylationGO:00423261660.018
organic hydroxy compound biosynthetic processGO:1901617770.018
regulation of apoptotic signaling pathwayGO:20012331970.018
positive regulation of neuron differentiationGO:00456661410.018
regulation of gtp catabolic processGO:00331241130.018
actin cytoskeleton organizationGO:00300362200.018
organonitrogen compound biosynthetic processGO:19015661920.018
regulation of lymphocyte activationGO:00512492400.018
transmembrane receptor protein tyrosine kinase signaling pathwayGO:00071692470.018
maintenance of locationGO:0051235890.018
female meiosis chromosome segregationGO:001632110.018
protein oligomerizationGO:0051259670.017
response to growth factorGO:00708481980.017
monocarboxylic acid biosynthetic processGO:0072330610.017
Human
positive regulation of nervous system developmentGO:00519622210.017
alcohol metabolic processGO:00060661160.017
Human
ossificationGO:00015032160.017
organic acid transportGO:00158491010.017
Human
positive regulation of gtpase activityGO:0043547850.017
transmission of nerve impulseGO:0019226760.017
positive regulation of nucleotide metabolic processGO:00459811140.017
ubiquitin dependent protein catabolic processGO:00065111290.017
regulation of cell migrationGO:00303342190.017
localization within membraneGO:005166840.017
cation homeostasisGO:00550802120.017
cytoplasmic transportGO:00164822340.017
protein localization to vacuoleGO:007266540.017
regulation of intracellular transportGO:00323861590.016
regulation of translationGO:0006417710.016
positive regulation of nucleoside metabolic processGO:0045979910.016
cellular response to peptideGO:1901653920.016
fat cell differentiationGO:00454441600.016
regulation of synaptic plasticityGO:0048167870.016
fatty acid alpha oxidationGO:000156120.016
regulation of reactive oxygen species metabolic processGO:2000377400.016
negative regulation of protein phosphorylationGO:00019331260.016
regulation of cell motilityGO:20001452360.016
regulation of neuron deathGO:19012141340.016
protein targeting to vacuoleGO:000662330.016
negative regulation of neuron deathGO:1901215980.016
positive regulation of purine nucleotide metabolic processGO:19005441140.016
cellular response to transforming growth factor beta stimulusGO:0071560880.016
positive regulation of hydrolase activityGO:00513451480.016
regulation of mapk cascadeGO:00434082480.015
lipid transportGO:0006869980.015
Human
endocytosisGO:00068971680.015
neuron deathGO:00709971540.015
regulation of kinase activityGO:00435492490.015
gtp catabolic processGO:00061841430.015
negative regulation of ras protein signal transductionGO:0046580180.015
neuronal action potentialGO:0019228540.015
regulation of ras protein signal transductionGO:00465781140.015
cellular response to cytokine stimulusGO:00713451890.015
proteasomal protein catabolic processGO:0010498980.015
cofactor biosynthetic processGO:0051188410.015
regulation of transmembrane receptor protein serine threonine kinase signaling pathwayGO:00900921120.015
fatty acid oxidationGO:0019395280.015
regulation of secretion by cellGO:19035302490.015
anatomical structure homeostasisGO:00602491450.015
carboxylic acid biosynthetic processGO:0046394860.015
Human
glycerolipid metabolic processGO:00464861220.015
Human
response to organic cyclic compoundGO:00140701980.014
cellularizationGO:000734910.014
response to uvGO:0009411440.014
regulation of secretionGO:00510462740.014
male gamete generationGO:00482322850.014
glycosyl compound catabolic processGO:19016582060.014
pyrimidine containing compound catabolic processGO:007252930.014
developmental maturationGO:00217001930.014
regulation of ossificationGO:00302781120.014
negative regulation of cellular response to growth factor stimulusGO:0090288460.014
leukocyte differentiationGO:00025213420.014
chromatin organizationGO:00063252060.014
response to drugGO:0042493750.014
modification dependent protein catabolic processGO:00199411330.014
regulation of neuron apoptotic processGO:00435231220.014
sensory perceptionGO:00076002450.014
adaptive immune responseGO:00022501550.014
adult behaviorGO:00305341350.014
mitotic nuclear divisionGO:0007067480.014
mitotic cell cycleGO:00002781950.014
retrograde transport endosome to golgiGO:004214720.014
cellular lipid metabolic processGO:00442553230.013
Human
coenzyme biosynthetic processGO:0009108230.013
brown fat cell differentiationGO:0050873360.013
ion transmembrane transportGO:00342203610.013
negative regulation of cell cycleGO:00457861230.013
regulation of innate immune responseGO:0045088910.013
response to endoplasmic reticulum stressGO:0034976530.013
negative regulation of mapk cascadeGO:0043409650.013
cellular response to nutrient levelsGO:0031669640.013
regulation of protein catabolic processGO:00421761080.013
cellular response to insulin stimulusGO:0032869780.013
immune effector processGO:00022523210.013
apoptotic signaling pathwayGO:00971903060.013
regulation of t cell proliferationGO:0042129920.013
chiasma assemblyGO:005102660.013
regulation of cellular response to growth factor stimulusGO:0090287820.013
nucleotide biosynthetic processGO:0009165780.013
chromosome segregationGO:0007059480.013
regulation of rho protein signal transductionGO:0035023710.013
membrane fusionGO:0061025380.013
regulation of cellular component sizeGO:00325351210.013
response to acid chemicalGO:00011011110.013
tissue homeostasisGO:00018941150.013
stem cell developmentGO:00488642190.013
regulation of cell cycle processGO:00105641600.013
response to transforming growth factor betaGO:0071559880.013
early endosome to late endosome transportGO:004502220.013
skeletal system morphogenesisGO:00487052030.013
cellular response to lipidGO:00713961450.013
negative regulation of molecular functionGO:00440922580.013
lateral inhibitionGO:004633110.013
positive regulation of transferase activityGO:00513471670.012
carbohydrate derivative biosynthetic processGO:19011371830.012
cytokine productionGO:00018163190.012
myeloid leukocyte differentiationGO:00025731190.012
protein importGO:00170381010.012
immune response regulating signaling pathwayGO:00027641250.012
compound eye developmentGO:004874910.012
regulation of proteolysisGO:00301621640.012
lipoprotein metabolic processGO:0042157430.012
lipid modificationGO:0030258650.012
chemotaxisGO:00069352470.012
positive regulation of programmed cell deathGO:00430682180.012
translational initiationGO:0006413240.012
nucleoside phosphate biosynthetic processGO:1901293790.012
cellular response to biotic stimulusGO:0071216920.012
muscle tissue developmentGO:00605373080.012
cellular response to peptide hormone stimulusGO:0071375920.012
regulation of protein kinase activityGO:00458592320.012
phosphatidylethanolamine biosynthetic processGO:000664620.012
regulation of autophagyGO:0010506300.012
locomotory behaviorGO:00076261950.012
immune response activating signal transductionGO:00027571160.012
regulation of fatty acid metabolic processGO:0019217280.012
ribonucleoprotein complex localizationGO:007116610.012
response to insulinGO:00328681000.012
stress activated protein kinase signaling cascadeGO:0031098810.012
regulation of cellular protein catabolic processGO:1903362610.012
regulation of lymphocyte anergyGO:000291140.012
cellular chemical homeostasisGO:00550822150.012
regulation of vesicle mediated transportGO:00606271390.011
blood circulationGO:00080151950.011
regulation of protein serine threonine kinase activityGO:00719001570.011
regionalizationGO:00030023370.011
negative regulation of defense responseGO:0031348770.011
neuron apoptotic processGO:00514021420.011
regulation of cell cycleGO:00517262810.011
regulation of cell sizeGO:0008361720.011
regulation of protein transportGO:00512231630.011
myeloid cell differentiationGO:00300992330.011
acylglycerol metabolic processGO:0006639550.011
regulation of t cell activationGO:00508631700.011
neural tube closureGO:0001843900.011
microtubule cytoskeleton organizationGO:00002261570.011
amino acid transportGO:0006865610.011
sterol transportGO:0015918380.011
p38mapk cascadeGO:003806640.011
ensheathment of neuronsGO:0007272760.011
cellular response to extracellular stimulusGO:0031668810.011
cellular response to acid chemicalGO:0071229680.011
regulation of lymphocyte proliferationGO:00506701170.011
regulation of leukocyte differentiationGO:19021051590.011
positive regulation of secretion by cellGO:19035321140.011
regulation of reactive oxygen species biosynthetic processGO:190342620.011
homeostasis of number of cellsGO:00488722100.011
g protein coupled receptor signaling pathwayGO:00071862430.011
organic acid catabolic processGO:0016054510.011
cell adhesionGO:00071553290.011
divalent metal ion transportGO:00708381720.011
spermatid developmentGO:00072861080.011
cellular protein complex assemblyGO:00436231160.011
er associated ubiquitin dependent protein catabolic processGO:0030433100.011
dna endoreduplicationGO:004202340.011
protein modification by small protein conjugationGO:00324461870.011
positive regulation of apoptotic signaling pathwayGO:2001235950.011
regulation of cytoplasmic translationGO:200076540.011
copii coated vesicle buddingGO:009011420.011
lipid catabolic processGO:0016042690.011
Human
epithelial tube morphogenesisGO:00605623030.011
defense response to bacteriumGO:00427421190.011
positive regulation of cell migrationGO:00303351090.011
rab protein signal transductionGO:003248210.011
negative regulation of transmembrane receptor protein serine threonine kinase signaling pathwayGO:0090101610.010
hormone secretionGO:00468791280.010
negative regulation of growthGO:0045926990.010
connective tissue developmentGO:00614481790.010
regulation of steroid biosynthetic processGO:0050810260.010
myelinationGO:0042552740.010
negative regulation of organelle organizationGO:0010639900.010
regulation of mrna polyadenylationGO:190036310.010
regulation of cell activationGO:00508652890.010
regulation of cytoplasmic transportGO:19036491120.010
exocytosisGO:00068871210.010
regulation of homeostatic processGO:00328441820.010
negative regulation of cell activationGO:00508661110.010
meiosis iGO:0007127600.010
positive regulation of neuron projection developmentGO:0010976790.010
nuclear importGO:0051170950.010
endomembrane system organizationGO:00102561470.010
lipid homeostasisGO:0055088630.010
positive regulation of cell developmentGO:00107202370.010
regulation of proteasomal ubiquitin dependent protein catabolic processGO:0032434400.010
centrosome separationGO:005129940.010
cellular response to external stimulusGO:0071496880.010
sensory organ morphogenesisGO:00905962420.010
synaptic transmissionGO:00072683290.010

Pnpla8 disease predictions

Disease predictions are made from cross-annotation of human disease genes to the identified functional analogs in mouse and predicted with the mouse functional network.

DiseaseDO term IDSizeProbabilityFunc Analog Org
nervous system diseaseDOID:86300.020
disease of anatomical entityDOID:700.020
disease of metabolismDOID:001466700.019
inherited metabolic disorderDOID:65500.017
sensory system diseaseDOID:005015500.016
eye diseaseDOID:561400.016
retinal degenerationDOID:846600.016
retinal diseaseDOID:567900.016
eye and adnexa diseaseDOID:149200.016