IMP: Integrative Multi-species Prediction

Mus musculus

48 known processes

Serping1

serine (or cysteine) peptidase inhibitor, clade G, member 1

(Aliases: C1INH,C1nh)

Entrez: 12258
Ensembl: ENSMUSG00000023224
UniProtKB: P97290

Process Predictions
Disease Predictions

Serping1 biological process predictions

Show only novel predictionsHighlight processes of functional analogs

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Biological process	GO term ID	Process size	Probability	Func Analog Org
negative regulation of proteolysis	GO:0045861	74	0.718
complement activation	GO:0006956	16	0.698	Human
regulation of peptidase activity	GO:0052547	96	0.585
protein activation cascade	GO:0072376	19	0.479	Human
angiogenesis	GO:0001525	201	0.460	Mouse
protein processing	GO:0016485	163	0.456
positive regulation of activation of membrane attack complex	GO:0001970	2	0.418
amine metabolic process	GO:0009308	45	0.401
protein maturation	GO:0051604	176	0.386
negative regulation of protein metabolic process	GO:0051248	282	0.385
regulation of endopeptidase activity	GO:0052548	89	0.354
response to organic cyclic compound	GO:0014070	198	0.338
regulation of proteolysis	GO:0030162	164	0.319
immune effector process	GO:0002252	321	0.283	Human
positive regulation of protein phosphorylation	GO:0001934	242	0.278
establishment of blood nerve barrier	GO:0008065	3	0.274
negative regulation of hydrolase activity	GO:0051346	71	0.274
innate immune response	GO:0045087	157	0.268	Human
carbohydrate metabolic process	GO:0005975	230	0.264
response to lipopolysaccharide	GO:0032496	128	0.263
negative regulation of endopeptidase activity	GO:0010951	44	0.257
regulation of cellular ketone metabolic process	GO:0010565	66	0.245
humoral immune response	GO:0006959	57	0.244	Human
mapk cascade	GO:0000165	281	0.244
regulation of cellular amine metabolic process	GO:0033238	20	0.234
cellular ketone metabolic process	GO:0042180	84	0.227
extracellular matrix organization	GO:0030198	147	0.219	Mouse
ossification	GO:0001503	216	0.215
monosaccharide metabolic process	GO:0005996	106	0.215
cellular lipid metabolic process	GO:0044255	323	0.214
glucose metabolic process	GO:0006006	92	0.213
response to steroid hormone	GO:0048545	56	0.207
response to molecule of bacterial origin	GO:0002237	143	0.200
kidney development	GO:0001822	213	0.199
regulation of blood pressure	GO:0008217	93	0.198	Mouse
regulation of cell motility	GO:2000145	236	0.192
negative regulation of tooth mineralization	GO:0070171	1	0.190
regulation of angiogenesis	GO:0045765	81	0.188	Mouse
type b pancreatic cell proliferation	GO:0044342	10	0.183
regulation of cellular amino acid metabolic process	GO:0006521	5	0.180
cell adhesion	GO:0007155	329	0.178
negative regulation of cell migration	GO:0030336	59	0.177
response to peptide	GO:1901652	136	0.177
oxidation reduction process	GO:0055114	342	0.166
regulation of epithelial cell proliferation	GO:0050678	141	0.164	Mouse
cellular amine metabolic process	GO:0044106	44	0.163
endothelium development	GO:0003158	45	0.160
negative regulation of peptidase activity	GO:0010466	46	0.159
carbohydrate homeostasis	GO:0033500	128	0.157
regulation of cytokine production	GO:0001817	266	0.156	Mouse
positive regulation of protein kinase b signaling	GO:0051897	32	0.154
regulation of defense response	GO:0031347	233	0.154	Human
triglyceride metabolic process	GO:0006641	51	0.150
cellular response to growth factor stimulus	GO:0071363	197	0.149
myeloid cell differentiation	GO:0030099	233	0.144
peptidyl amino acid modification	GO:0018193	336	0.143
response to organonitrogen compound	GO:0010243	246	0.142
epithelial tube morphogenesis	GO:0060562	303	0.141
blood vessel morphogenesis	GO:0048514	285	0.141	Mouse
regulation of glucose metabolic process	GO:0010906	60	0.140
glycerolipid metabolic process	GO:0046486	122	0.139
regulation of vasculature development	GO:1901342	88	0.132	Mouse
chondroitin sulfate proteoglycan metabolic process	GO:0050654	20	0.129
cellular response to peptide	GO:1901653	92	0.127
positive regulation of behavior	GO:0048520	40	0.126
glucose homeostasis	GO:0042593	128	0.125
negative regulation of cellular protein metabolic process	GO:0032269	247	0.125
cell substrate adhesion	GO:0031589	130	0.124
regulation of cell migration	GO:0030334	219	0.121
macromolecule glycosylation	GO:0043413	55	0.119
response to interferon gamma	GO:0034341	34	0.118
positive regulation of cytokine production	GO:0001819	174	0.117	Mouse
positive regulation of mapk cascade	GO:0043410	170	0.117
cellular response to cytokine stimulus	GO:0071345	189	0.116
regulation of tooth mineralization	GO:0070170	2	0.114
positive regulation of protein kinase c activity	GO:1900020	1	0.113
cell matrix adhesion	GO:0007160	68	0.112
positive regulation of nervous system development	GO:0051962	221	0.112
peptidyl serine modification	GO:0018209	83	0.110
astrocyte activation	GO:0048143	2	0.109
regulation of hydrolase activity	GO:0051336	246	0.108
positive regulation of fatty acid biosynthetic process	GO:0045723	3	0.108
transmembrane receptor protein tyrosine kinase signaling pathway	GO:0007169	247	0.106
negative regulation of protein maturation	GO:1903318	79	0.106
adaptive immune response based on somatic recombination of immune receptors built from immunoglobulin superfamily domains	GO:0002460	145	0.103
positive regulation of chemotaxis	GO:0050921	38	0.100
ovarian follicle rupture	GO:0001543	2	0.100
regulation of transferase activity	GO:0051338	263	0.098
hexose metabolic process	GO:0019318	98	0.098
morphogenesis of a branching epithelium	GO:0061138	193	0.098
inflammatory response	GO:0006954	244	0.097	Human
regulation of protein processing	GO:0070613	96	0.097
lymphocyte mediated immunity	GO:0002449	139	0.096
peptide cross linking	GO:0018149	10	0.094
negative regulation of odontogenesis	GO:0042483	3	0.094
organic hydroxy compound metabolic process	GO:1901615	203	0.094
blood circulation	GO:0008015	195	0.093	Mouse
lipid biosynthetic process	GO:0008610	179	0.093
response to peptide hormone	GO:0043434	127	0.091
chemotaxis	GO:0006935	247	0.091
negative regulation of phosphorus metabolic process	GO:0010563	184	0.089
gluconeogenesis	GO:0006094	39	0.089
regulation of fatty acid metabolic process	GO:0019217	28	0.088
cellular response to organonitrogen compound	GO:0071417	145	0.088
cellular response to hormone stimulus	GO:0032870	150	0.086
glycoprotein metabolic process	GO:0009100	116	0.086
production of molecular mediator of immune response	GO:0002440	103	0.085
lung development	GO:0030324	164	0.085
negative regulation of molecular function	GO:0044092	258	0.085
endocrine process	GO:0050886	39	0.083	Mouse
regulation of lipid metabolic process	GO:0019216	118	0.082
cytokine production	GO:0001816	319	0.082	Mouse
regulation of hormone levels	GO:0010817	211	0.082
negative regulation of cell proliferation	GO:0008285	296	0.081	Mouse
regulation of carbohydrate metabolic process	GO:0006109	75	0.080
negative regulation of protein processing	GO:0010955	79	0.080
regulation of protein kinase activity	GO:0045859	232	0.079
epithelial cell proliferation	GO:0050673	174	0.079	Mouse
regulation of kinase activity	GO:0043549	249	0.079
cholesterol metabolic process	GO:0008203	56	0.078
regulation of inflammatory response	GO:0050727	147	0.078	Human
gland development	GO:0048732	330	0.078	Mouse
positive regulation of angiogenesis	GO:0045766	46	0.076
negative regulation of cellular carbohydrate metabolic process	GO:0010677	19	0.073
neutral lipid metabolic process	GO:0006638	57	0.072
camera type eye development	GO:0043010	266	0.072
positive regulation of transferase activity	GO:0051347	167	0.072
sulfur compound metabolic process	GO:0006790	100	0.072
positive regulation of protein modification process	GO:0031401	299	0.070
response to insulin	GO:0032868	100	0.070
regulation of cell growth	GO:0001558	91	0.070
positive regulation of neutrophil migration	GO:1902624	12	0.070
terpenoid metabolic process	GO:0006721	25	0.069
female sex differentiation	GO:0046660	84	0.069
positive regulation of inflammatory response	GO:0050729	47	0.069
muscle tissue development	GO:0060537	308	0.068
transmembrane receptor protein serine threonine kinase signaling pathway	GO:0007178	194	0.067
chondroitin sulfate metabolic process	GO:0030204	17	0.066
urogenital system development	GO:0001655	261	0.066	Mouse
mucopolysaccharide metabolic process	GO:1903510	25	0.066
acylglycerol metabolic process	GO:0006639	55	0.065
regulation of cellular carbohydrate metabolic process	GO:0010675	75	0.065
positive regulation of cellular amino acid metabolic process	GO:0045764	3	0.065
positive regulation of peptidyl serine phosphorylation	GO:0033138	25	0.064
small molecule biosynthetic process	GO:0044283	132	0.064
lateral line system development	GO:0048925	1	0.063
positive regulation of insulin receptor signaling pathway	GO:0046628	4	0.063
renal system development	GO:0072001	225	0.063
response to growth factor	GO:0070848	198	0.062
morphogenesis of a branching structure	GO:0001763	203	0.062
response to inorganic substance	GO:0010035	96	0.062
entry into cell of other organism involved in symbiotic interaction	GO:0051806	15	0.062
regulation of mapk cascade	GO:0043408	248	0.061
regulation of apoptotic signaling pathway	GO:2001233	197	0.061
glial cell differentiation	GO:0010001	131	0.059
embryonic organ morphogenesis	GO:0048562	276	0.059
response to oxidative stress	GO:0006979	123	0.058
positive regulation of cellular amine metabolic process	GO:0033240	5	0.058
respiratory tube development	GO:0030323	167	0.057
response to acid chemical	GO:0001101	111	0.057
cellular response to insulin stimulus	GO:0032869	78	0.056
multicellular organism growth	GO:0035264	161	0.056
respiratory system development	GO:0060541	190	0.056
cellular amino acid metabolic process	GO:0006520	103	0.056
negative regulation of cell motility	GO:2000146	61	0.055
cellular response to peptide hormone stimulus	GO:0071375	92	0.055
endothelial cell development	GO:0001885	20	0.054
long chain fatty acid import	GO:0044539	2	0.054
epidermis development	GO:0008544	187	0.054
circulatory system process	GO:0003013	197	0.053	Mouse
nephron development	GO:0072006	109	0.053
peptidyl tyrosine modification	GO:0018212	145	0.052
skin development	GO:0043588	220	0.052
adaptive immune response	GO:0002250	155	0.052
fatty acid metabolic process	GO:0006631	121	0.052
negative regulation of protein phosphorylation	GO:0001933	126	0.052
wound healing	GO:0042060	157	0.051
negative regulation of transmembrane receptor protein serine threonine kinase signaling pathway	GO:0090101	61	0.050
negative regulation of phosphorylation	GO:0042326	166	0.050
hexose transport	GO:0008645	56	0.049
proteoglycan metabolic process	GO:0006029	38	0.049
brown fat cell differentiation	GO:0050873	36	0.049
regulation of protein maturation	GO:1903317	96	0.049
peptidyl tyrosine phosphorylation	GO:0018108	143	0.048
cellular response to transforming growth factor beta stimulus	GO:0071560	88	0.047
protein kinase b signaling	GO:0043491	74	0.047
epithelial cell development	GO:0002064	159	0.047
developmental growth involved in morphogenesis	GO:0060560	138	0.047
fat cell differentiation	GO:0045444	160	0.047
kidney epithelium development	GO:0072073	121	0.046
response to corticosteroid	GO:0031960	20	0.046
response to osmotic stress	GO:0006970	21	0.045
regulation of cellular response to growth factor stimulus	GO:0090287	82	0.045
regulation of gluconeogenesis	GO:0006111	30	0.045
response to monosaccharide	GO:0034284	67	0.044
regulation of anatomical structure size	GO:0090066	178	0.044	Mouse
positive regulation of erk1 and erk2 cascade	GO:0070374	47	0.044
sensory system development	GO:0048880	3	0.044
connective tissue development	GO:0061448	179	0.043
glycosaminoglycan metabolic process	GO:0030203	34	0.043
activation of immune response	GO:0002253	138	0.043	Human
cell chemotaxis	GO:0060326	81	0.043
diterpenoid metabolic process	GO:0016101	24	0.043
cell cell adhesion	GO:0098609	41	0.042
negative regulation of protein modification process	GO:0031400	163	0.042
intrinsic apoptotic signaling pathway	GO:0097193	132	0.042
positive regulation of glucose transport	GO:0010828	16	0.042
regulation of cellular response to insulin stimulus	GO:1900076	30	0.041
nucleoside phosphate metabolic process	GO:0006753	338	0.041
gliogenesis	GO:0042063	141	0.041
cytokine mediated signaling pathway	GO:0019221	115	0.040
activation of nf kappab inducing kinase activity	GO:0007250	4	0.040
positive regulation of growth	GO:0045927	104	0.040
small gtpase mediated signal transduction	GO:0007264	97	0.040
positive regulation of kinase activity	GO:0033674	155	0.040
angiotensin mediated vasoconstriction involved in regulation of systemic arterial blood pressure	GO:0001998	3	0.040
peptide cross linking via chondroitin 4 sulfate glycosaminoglycan	GO:0019800	8	0.039
sensory organ morphogenesis	GO:0090596	242	0.039
branching morphogenesis of an epithelial tube	GO:0048754	159	0.038
negative regulation of intracellular signal transduction	GO:1902532	167	0.038
spermatogenesis	GO:0007283	284	0.038
defense response to other organism	GO:0098542	197	0.038
female gonad development	GO:0008585	71	0.037
positive regulation of protein activation cascade	GO:2000259	2	0.037
regulation of secretion	GO:0051046	274	0.036
regulation of intrinsic apoptotic signaling pathway	GO:2001242	61	0.036
entry into other organism involved in symbiotic interaction	GO:0051828	15	0.036
regulation of transmembrane receptor protein serine threonine kinase signaling pathway	GO:0090092	112	0.036
negative regulation of epithelial cell proliferation	GO:0050680	64	0.035	Mouse
cellular carbohydrate metabolic process	GO:0044262	119	0.035
homeostasis of number of cells	GO:0048872	210	0.035
hormone metabolic process	GO:0042445	86	0.035
negative regulation of phosphate metabolic process	GO:0045936	184	0.035
transforming growth factor beta receptor signaling pathway	GO:0007179	71	0.035
regulation of protein secretion	GO:0050708	82	0.035
glucocorticoid metabolic process	GO:0008211	9	0.034
striated muscle tissue development	GO:0014706	293	0.034
regulation of complement activation	GO:0030449	7	0.034	Human
monosaccharide biosynthetic process	GO:0046364	44	0.034
response to alcohol	GO:0097305	48	0.034
response to nutrient levels	GO:0031667	109	0.034
neuron death	GO:0070997	154	0.034
positive regulation of proteolysis	GO:0045862	85	0.033
nucleotide metabolic process	GO:0009117	332	0.033
regulation of organ morphogenesis	GO:2000027	144	0.033
positive regulation of cell development	GO:0010720	237	0.033
hexose biosynthetic process	GO:0019319	39	0.033
response to transforming growth factor beta	GO:0071559	88	0.033
positive regulation of apoptotic process	GO:0043065	217	0.033
ovulation cycle	GO:0042698	59	0.033
response to extracellular stimulus	GO:0009991	127	0.032
cellular response to organic cyclic compound	GO:0071407	87	0.032
negative regulation of immune system process	GO:0002683	209	0.032	Human
astrocyte differentiation	GO:0048708	43	0.032
negative regulation of transforming growth factor beta receptor signaling pathway	GO:0030512	26	0.032
regulation of fat cell differentiation	GO:0045598	81	0.032
regulation of osteoblast differentiation	GO:0045667	67	0.031
cartilage development	GO:0051216	140	0.031
extracellular structure organization	GO:0043062	148	0.031	Mouse
renal system process	GO:0003014	48	0.030	Mouse
nephron epithelium development	GO:0072009	92	0.030
apoptotic signaling pathway	GO:0097190	306	0.030
entry into host	GO:0044409	15	0.030
monosaccharide transport	GO:0015749	58	0.029
regulation of protein stability	GO:0031647	52	0.029
negative regulation of platelet derived growth factor receptor alpha signaling pathway	GO:2000584	2	0.029
regulation of protein kinase b signaling	GO:0051896	56	0.029
glucose transport	GO:0015758	56	0.028
regulation of ras protein signal transduction	GO:0046578	114	0.028
isoprenoid metabolic process	GO:0006720	29	0.028
response to radiation	GO:0009314	165	0.028
negative regulation of carbohydrate metabolic process	GO:0045912	19	0.028
muscle cell differentiation	GO:0042692	261	0.028
regulation of cholesterol metabolic process	GO:0090181	14	0.028
positive regulation of cell projection organization	GO:0031346	95	0.028
regulation of transforming growth factor beta receptor signaling pathway	GO:0017015	43	0.028
positive regulation of apoptotic cell clearance	GO:2000427	3	0.027
tooth mineralization	GO:0034505	9	0.027
cellular response to steroid hormone stimulus	GO:0071383	33	0.027
negative regulation of blood vessel morphogenesis	GO:2000181	25	0.027	Mouse
regulation of response to wounding	GO:1903034	189	0.027	Human
macromolecule catabolic process	GO:0009057	281	0.027
positive regulation of endopeptidase activity	GO:0010950	43	0.027
nitrogen compound transport	GO:0071705	271	0.027
regulation of systemic arterial blood pressure mediated by a chemical signal	GO:0003044	33	0.026	Mouse
leukocyte tethering or rolling	GO:0050901	3	0.026
insulin receptor signaling pathway	GO:0008286	49	0.026
muscle cell proliferation	GO:0033002	52	0.026	Mouse
cellular protein catabolic process	GO:0044257	155	0.026
development of primary sexual characteristics	GO:0045137	143	0.026
response to metal ion	GO:0010038	47	0.026
anatomical structure homeostasis	GO:0060249	145	0.026
cell growth	GO:0016049	130	0.025
alcohol metabolic process	GO:0006066	116	0.025
positive regulation of hydrolase activity	GO:0051345	148	0.025
retinoid metabolic process	GO:0001523	24	0.025
positive regulation of protein kinase activity	GO:0045860	144	0.025
neutrophil migration	GO:1990266	37	0.025
protein glycosylation	GO:0006486	55	0.025
skeletal system morphogenesis	GO:0048705	203	0.025
nephron tubule development	GO:0072080	84	0.025
organonitrogen compound biosynthetic process	GO:1901566	192	0.024
regulation of renal output by angiotensin	GO:0002019	2	0.024
negative regulation of gluconeogenesis	GO:0045721	9	0.024
regulation of glucose transport	GO:0010827	32	0.024
metanephric glomerular visceral epithelial cell development	GO:0072249	2	0.024
adiponectin secretion	GO:0070162	2	0.024
skin morphogenesis	GO:0043589	38	0.024
entry into host cell	GO:0030260	15	0.024
positive regulation of reactive oxygen species biosynthetic process	GO:1903428	2	0.024
defense response to gram positive bacterium	GO:0050830	50	0.024
regulation of platelet derived growth factor receptor alpha signaling pathway	GO:2000583	2	0.024
regulation of cell projection organization	GO:0031344	206	0.024
transmembrane transport	GO:0055085	412	0.024
heart morphogenesis	GO:0003007	178	0.023
negative regulation of apoptotic signaling pathway	GO:2001234	104	0.023
hormone secretion	GO:0046879	128	0.023
carbohydrate transport	GO:0008643	62	0.023
negative regulation of cellular response to growth factor stimulus	GO:0090288	46	0.023
regulation of peptidyl tyrosine phosphorylation	GO:0050730	93	0.023
cellular homeostasis	GO:0019725	240	0.023
glycosylation	GO:0070085	62	0.023
negative regulation of intrinsic apoptotic signaling pathway	GO:2001243	34	0.023
regulation of reactive oxygen species biosynthetic process	GO:1903426	2	0.023
regulation of lymphocyte mediated immunity	GO:0002706	84	0.022
regulation of tube size	GO:0035150	57	0.022	Mouse
regulation of cell size	GO:0008361	72	0.022
carbohydrate biosynthetic process	GO:0016051	74	0.022
regulation of establishment of protein localization	GO:0070201	181	0.022
regulation of protein activation cascade	GO:2000257	7	0.022	Human
aminoglycan metabolic process	GO:0006022	34	0.022
regulation of systemic arterial blood pressure by hormone	GO:0001990	25	0.022	Mouse
regulation of neuron apoptotic process	GO:0043523	122	0.022
phagocytosis	GO:0006909	66	0.022
cell type specific apoptotic process	GO:0097285	268	0.021
male gamete generation	GO:0048232	285	0.021
immunoglobulin mediated immune response	GO:0016064	69	0.021
engulfment of apoptotic cell	GO:0043652	3	0.021
cellular response to molecule of bacterial origin	GO:0071219	83	0.021
cellular response to monosaccharide stimulus	GO:0071326	47	0.021
regulation of cell adhesion	GO:0030155	154	0.021
regulation of acute inflammatory response	GO:0002673	27	0.021	Human
regulation of secretion by cell	GO:1903530	249	0.021
regulation of neuron projection development	GO:0010975	169	0.020
interleukin 27 mediated signaling pathway	GO:0070106	1	0.020
phosphatidylinositol 3 kinase signaling	GO:0014065	36	0.020
aromatic compound catabolic process	GO:0019439	286	0.020
peptidyl serine phosphorylation	GO:0018105	74	0.020
regulation of neutrophil chemotaxis	GO:0090022	14	0.020
metanephric glomerular epithelium development	GO:0072244	3	0.019
nuclear import	GO:0051170	95	0.019
cerebellum development	GO:0021549	77	0.019
movement in host environment	GO:0052126	15	0.019
cellular response to glucocorticoid stimulus	GO:0071385	13	0.019
mitochondrion organization	GO:0007005	134	0.019
epithelium migration	GO:0090132	63	0.019
glycoprotein biosynthetic process	GO:0009101	89	0.019
regulation of neuron death	GO:1901214	134	0.019
nephron morphogenesis	GO:0072028	69	0.018
stem cell differentiation	GO:0048863	268	0.018
regulation of neuron differentiation	GO:0045664	281	0.018
epithelial cell migration	GO:0010631	63	0.018
lipid catabolic process	GO:0016042	69	0.018
fat soluble vitamin biosynthetic process	GO:0042362	4	0.018
regulation of protein serine threonine kinase activity	GO:0071900	157	0.018
complement activation lectin pathway	GO:0001867	5	0.018	Human
peptide secretion	GO:0002790	114	0.018
neuron apoptotic process	GO:0051402	142	0.018
movement in environment of other organism involved in symbiotic interaction	GO:0052192	15	0.018
positive regulation of complement activation	GO:0045917	2	0.018
formation of primary germ layer	GO:0001704	77	0.018
renal control of peripheral vascular resistance involved in regulation of systemic arterial blood pressure	GO:0003072	5	0.018	Mouse
tissue homeostasis	GO:0001894	115	0.018
fatty acid oxidation	GO:0019395	28	0.017
metencephalon development	GO:0022037	89	0.017
negative regulation of viral entry into host cell	GO:0046597	10	0.017
regulation of transmission of nerve impulse	GO:0051969	1	0.017
regulation of adaptive immune response	GO:0002819	90	0.017
positive regulation of peptidase activity	GO:0010952	49	0.017
hindbrain morphogenesis	GO:0021575	46	0.017
reactive oxygen species metabolic process	GO:0072593	84	0.017
limb development	GO:0060173	166	0.017
protein localization to organelle	GO:0033365	185	0.017
positive regulation of cytokine secretion	GO:0050715	41	0.017
response to decreased oxygen levels	GO:0036293	59	0.017
response to purine containing compound	GO:0014074	28	0.017
negative regulation of ossification	GO:0030279	49	0.017
mineralocorticoid biosynthetic process	GO:0006705	1	0.017
ear development	GO:0043583	200	0.017
reactive oxygen species biosynthetic process	GO:1903409	8	0.017
morphogenesis of embryonic epithelium	GO:0016331	159	0.016
response to reactive oxygen species	GO:0000302	56	0.016
regulation of metanephric mesenchymal cell migration	GO:2000589	2	0.016
extrinsic apoptotic signaling pathway	GO:0097191	126	0.016
sterol metabolic process	GO:0016125	58	0.016
positive regulation of glucose import	GO:0046326	14	0.016
actin cytoskeleton organization	GO:0030036	220	0.016
response to nutrient	GO:0007584	12	0.016
positive regulation of endocytosis	GO:0045807	42	0.016
regulation of cysteine type endopeptidase activity	GO:2000116	65	0.016
regulation of lipid biosynthetic process	GO:0046890	54	0.016
skeletal system development	GO:0001501	356	0.016
b cell mediated immunity	GO:0019724	71	0.016
establishment or maintenance of cell polarity	GO:0007163	86	0.016
negative regulation of kinase activity	GO:0033673	81	0.016
odontogenesis	GO:0042476	78	0.016
interleukin 8 production	GO:0032637	4	0.016
cellular response to interferon gamma	GO:0071346	25	0.016
positive regulation of adaptive immune response based on somatic recombination of immune receptors built from immunoglobulin superfamily domains	GO:0002824	61	0.016
posttranscriptional regulation of gene expression	GO:0010608	155	0.016
defense response to virus	GO:0051607	68	0.016
immunoglobulin production	GO:0002377	73	0.015
regulation of phospholipid biosynthetic process	GO:0071071	3	0.015
establishment of tissue polarity	GO:0007164	28	0.015
lipid modification	GO:0030258	65	0.015
regulation of cellular response to stress	GO:0080135	159	0.015
transition metal ion transport	GO:0000041	38	0.015
heterocycle catabolic process	GO:0046700	280	0.015
cellular nitrogen compound catabolic process	GO:0044270	280	0.015
negative regulation of biomineral tissue development	GO:0070168	11	0.015
negative regulation of oxidative stress induced intrinsic apoptotic signaling pathway	GO:1902176	4	0.015
response to glucocorticoid	GO:0051384	20	0.015
regulation of striated muscle cell differentiation	GO:0051153	81	0.015
kidney morphogenesis	GO:0060993	83	0.015
cardiac muscle tissue development	GO:0048738	130	0.015
morphogenesis of a polarized epithelium	GO:0001738	37	0.015
regulation of erk1 and erk2 cascade	GO:0070372	71	0.015
cellular response to lipid	GO:0071396	145	0.015
carbohydrate derivative biosynthetic process	GO:1901137	183	0.015
negative regulation of cellular amine metabolic process	GO:0033239	1	0.015
positive regulation of lipid metabolic process	GO:0045834	40	0.015
metanephric glomerular epithelial cell development	GO:0072313	2	0.015
regulation of carbohydrate biosynthetic process	GO:0043255	40	0.015
intrinsic apoptotic signaling pathway in response to oxidative stress	GO:0008631	19	0.015
positive regulation of defense response	GO:0031349	124	0.015
neuromuscular process	GO:0050905	99	0.015
tissue migration	GO:0090130	68	0.015
iron ion homeostasis	GO:0055072	36	0.015
neutrophil chemotaxis	GO:0030593	36	0.015
cellular response to dna damage stimulus	GO:0006974	207	0.014
import into cell	GO:0098657	8	0.014
peptide transport	GO:0015833	133	0.014
regulation of reactive oxygen species metabolic process	GO:2000377	40	0.014
leukocyte migration	GO:0050900	124	0.014
negative regulation of leukocyte differentiation	GO:1902106	51	0.014
regulation of fatty acid biosynthetic process	GO:0042304	12	0.014
lipid oxidation	GO:0034440	29	0.014
renal tubule development	GO:0061326	87	0.014
neuron projection extension	GO:1990138	64	0.014
nucleotide catabolic process	GO:0009166	217	0.014
negative regulation of response to oxidative stress	GO:1902883	10	0.014
cellular chemical homeostasis	GO:0055082	215	0.014
positive regulation of granulocyte chemotaxis	GO:0071624	12	0.014
skeletal muscle organ development	GO:0060538	163	0.014
platelet derived growth factor receptor alpha signaling pathway	GO:0035790	3	0.014
acute inflammatory response	GO:0002526	41	0.014	Human
neural tube formation	GO:0001841	108	0.014
regulation of viral entry into host cell	GO:0046596	12	0.014
axonogenesis	GO:0007409	274	0.014
regionalization	GO:0003002	337	0.013
regulation of syncytium formation by plasma membrane fusion	GO:0060142	23	0.013
regulation of protein localization	GO:0032880	231	0.013
limb morphogenesis	GO:0035108	149	0.013
cardiac chamber morphogenesis	GO:0003206	93	0.013
positive regulation of camp dependent protein kinase activity	GO:2000481	3	0.013
cellular biogenic amine metabolic process	GO:0006576	28	0.013
hair cycle	GO:0042633	90	0.013
astrocyte development	GO:0014002	12	0.013
bmp signaling pathway	GO:0030509	93	0.013
metanephric glomerular epithelial cell differentiation	GO:0072312	2	0.013
positive regulation of epithelial cell differentiation involved in kidney development	GO:2000698	2	0.013
regulation of phospholipase a2 activity	GO:0032429	3	0.013
nucleobase containing small molecule metabolic process	GO:0055086	352	0.013
interleukin 12 secretion	GO:0072610	3	0.013

Serping1 disease predictions

Disease predictions are made from cross-annotation of human disease genes to the identified functional analogs in mouse and predicted with the mouse functional network.

Disease	DO term ID	Probability	Func Analog Org
hemolytic anemia	DOID:583	0.686
disease of anatomical entity	DOID:7	0.686	Human
anemia	DOID:2355	0.686
normocytic anemia	DOID:720	0.686
hematopoietic system disease	DOID:74	0.686
immune system disease	DOID:2914	0.686
hemolytic uremic syndrome	DOID:12554	0.686
nervous system disease	DOID:863	0.110
disease of metabolism	DOID:0014667	0.086
inherited metabolic disorder	DOID:655	0.086
eye disease	DOID:5614	0.053
retinal disease	DOID:5679	0.053
sensory system disease	DOID:0050155	0.053
retinal degeneration	DOID:8466	0.053
eye and adnexa disease	DOID:1492	0.053
lipid metabolism disorder	DOID:3146	0.026
connective tissue disease	DOID:65	0.024
musculoskeletal system disease	DOID:17	0.024
bone disease	DOID:0080001	0.022
bone development disease	DOID:0080006	0.022
age related macular degeneration	DOID:10871	0.017
degeneration of macula and posterior pole	DOID:2007	0.017
macular degeneration	DOID:4448	0.017
acquired metabolic disease	DOID:0060158	0.016
osteochondrodysplasia	DOID:2256	0.014

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