IMP: Integrative Multi-species Prediction

Mus musculus

274 known processes

Efna1

ephrin A1

(Aliases: B61,Epl1,Eplg1,AI325262,Efl1,Lerk1)

Entrez: 13636
Ensembl: ENSMUSG00000027954
UniProtKB: D3YTT5
UniProtKB: Q9D7K8
UniProtKB: P52793

Process Predictions
Disease Predictions

Efna1 biological process predictions

Show only novel predictionsHighlight processes of functional analogs

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Biological process	GO term ID	Process size	Probability	Func Analog Org
leukocyte differentiation	GO:0002521	342	0.830	Mouse
t cell activation	GO:0042110	289	0.826	Mouse
angiogenesis	GO:0001525	201	0.792
axon target recognition	GO:0007412	4	0.721
lymphocyte differentiation	GO:0030098	242	0.717
t cell differentiation in thymus	GO:0033077	77	0.632
regulation of ras gtpase activity	GO:0032318	88	0.616	Mouse
immune effector process	GO:0002252	321	0.589
regulation of rho gtpase activity	GO:0032319	58	0.581	Mouse
mapk cascade	GO:0000165	281	0.569
activation of rac gtpase activity	GO:0032863	2	0.532
embryonic organ morphogenesis	GO:0048562	276	0.529
positive regulation of cell activation	GO:0050867	158	0.527	Mouse
myeloid leukocyte activation	GO:0002274	83	0.525
regulation of cellular amine metabolic process	GO:0033238	20	0.522
cellular amine metabolic process	GO:0044106	44	0.499
cell cell recognition	GO:0009988	44	0.488
muscle cell differentiation	GO:0042692	261	0.456	Mouse
regulation of hydrolase activity	GO:0051336	246	0.452	Mouse
rho protein signal transduction	GO:0007266	32	0.430
t cell differentiation	GO:0030217	174	0.429
positive regulation of cellular catabolic process	GO:0031331	148	0.422
positive regulation of t cell activation	GO:0050870	101	0.422	Mouse
regulation of cell migration	GO:0030334	219	0.421
cellular amino acid metabolic process	GO:0006520	103	0.404
positive regulation of rac gtpase activity	GO:0032855	14	0.393
purine nucleoside metabolic process	GO:0042278	241	0.384	Mouse
chemotaxis	GO:0006935	247	0.374	Mouse
t cell proliferation	GO:0042098	120	0.372	Mouse
ribonucleoside catabolic process	GO:0042454	206	0.368	Mouse
guanosine containing compound metabolic process	GO:1901068	144	0.351	Mouse
regulation of cellular catabolic process	GO:0031329	242	0.349	Mouse
adaptive immune response	GO:0002250	155	0.348
cell activation involved in immune response	GO:0002263	126	0.342
blood vessel endothelial cell migration	GO:0043534	23	0.341
amine metabolic process	GO:0009308	45	0.337
regulation of gtp catabolic process	GO:0033124	113	0.329	Mouse
positive regulation of protein phosphorylation	GO:0001934	242	0.327
positive regulation of protein modification process	GO:0031401	299	0.324
regulation of cellular amino acid metabolic process	GO:0006521	5	0.319
small gtpase mediated signal transduction	GO:0007264	97	0.316
myeloid cell activation involved in immune response	GO:0002275	34	0.314
positive regulation of nucleoside metabolic process	GO:0045979	91	0.312
positive regulation of ras gtpase activity	GO:0032320	65	0.311
activation of mapk activity involved in innate immune response	GO:0035419	2	0.310
regulation of gliogenesis	GO:0014013	50	0.305
positive regulation of protein kinase activity	GO:0045860	144	0.303
regulation of t cell proliferation	GO:0042129	92	0.300	Mouse
blood circulation	GO:0008015	195	0.299
regulation of neuron differentiation	GO:0045664	281	0.297
cellular ketone metabolic process	GO:0042180	84	0.297
positive regulation of rho gtpase activity	GO:0032321	41	0.292
organophosphate catabolic process	GO:0046434	232	0.290	Mouse
regulation of vasculature development	GO:1901342	88	0.288
skeletal muscle organ development	GO:0060538	163	0.286
positive regulation of mapk cascade	GO:0043410	170	0.285
regulation of purine nucleotide catabolic process	GO:0033121	122	0.280	Mouse
endocardial cushion to mesenchymal transition involved in heart valve formation	GO:0003199	4	0.275
action potential	GO:0001508	78	0.273
gtp catabolic process	GO:0006184	143	0.272	Mouse
pallium development	GO:0021543	120	0.271
single organismal cell cell adhesion	GO:0016337	131	0.269	Mouse
regulation of cytoskeleton organization	GO:0051493	122	0.262	Mouse
regulation of cell activation	GO:0050865	289	0.258	Mouse
neuron projection guidance	GO:0097485	141	0.257	Mouse
alpha beta t cell activation	GO:0046631	91	0.256
leukocyte activation involved in immune response	GO:0002366	126	0.252
actin cytoskeleton organization	GO:0030036	220	0.250	Mouse
positive regulation of thymocyte migration	GO:2000412	2	0.250
regulation of angiogenesis	GO:0045765	81	0.245
regulation of protein kinase activity	GO:0045859	232	0.240
regulation of mapk cascade	GO:0043408	248	0.238
ras protein signal transduction	GO:0007265	77	0.237
axon guidance	GO:0007411	141	0.233	Mouse
positive regulation of lymphocyte activation	GO:0051251	140	0.232	Mouse
nucleoside catabolic process	GO:0009164	206	0.230	Mouse
alpha beta t cell proliferation	GO:0046633	21	0.230
telencephalon development	GO:0021537	186	0.227
ameboidal type cell migration	GO:0001667	128	0.226
circulatory system process	GO:0003013	197	0.225
locomotory behavior	GO:0007626	195	0.224	Mouse
camera type eye development	GO:0043010	266	0.224
nucleotide catabolic process	GO:0009166	217	0.223	Mouse
cellular nitrogen compound catabolic process	GO:0044270	280	0.222	Mouse
divalent inorganic cation homeostasis	GO:0072507	138	0.217
nucleoside metabolic process	GO:0009116	246	0.216	Mouse
regulation of response to wounding	GO:1903034	189	0.216
ribose phosphate metabolic process	GO:0019693	291	0.214	Mouse
regulation of actin cytoskeleton organization	GO:0032956	84	0.212	Mouse
notochord formation	GO:0014028	5	0.211
gtp metabolic process	GO:0046039	144	0.208	Mouse
establishment of lymphocyte polarity	GO:0001767	2	0.196
purine nucleotide catabolic process	GO:0006195	211	0.196	Mouse
positive regulation of dendritic cell chemotaxis	GO:2000510	1	0.193
immune response regulating signaling pathway	GO:0002764	125	0.192
purine nucleoside triphosphate metabolic process	GO:0009144	226	0.191	Mouse
cerebral cortex cell migration	GO:0021795	44	0.191
response to growth factor	GO:0070848	198	0.189
neural precursor cell proliferation	GO:0061351	121	0.188
negative thymic t cell selection	GO:0045060	12	0.188
localization within membrane	GO:0051668	4	0.188
cellular extravasation	GO:0045123	17	0.188
synaptic transmission	GO:0007268	329	0.187
negative regulation of cell proliferation	GO:0008285	296	0.185	Mouse
peptidyl amino acid modification	GO:0018193	336	0.184
negative regulation of cell development	GO:0010721	169	0.184
heart contraction	GO:0060047	93	0.183
thymic t cell selection	GO:0045061	22	0.179
positive regulation of membrane protein ectodomain proteolysis	GO:0051044	3	0.176
forebrain cell migration	GO:0021885	58	0.176
muscular septum morphogenesis	GO:0003150	4	0.174
positive regulation of cellular amino acid metabolic process	GO:0045764	3	0.174
engulfment of apoptotic cell	GO:0043652	3	0.172
guanosine containing compound catabolic process	GO:1901069	144	0.168	Mouse
nucleoside phosphate metabolic process	GO:0006753	338	0.168	Mouse
regulation of transferase activity	GO:0051338	263	0.167
regulation of nucleoside metabolic process	GO:0009118	130	0.166	Mouse
cell recognition	GO:0008037	83	0.166	Mouse
positive regulation of phagocytosis	GO:0050766	26	0.164
cytoplasmic transport	GO:0016482	234	0.161
regulation of membrane potential	GO:0042391	192	0.161
blood vessel morphogenesis	GO:0048514	285	0.160
positive regulation of purine nucleotide catabolic process	GO:0033123	88	0.160
retinal ganglion cell axon guidance	GO:0031290	18	0.158	Mouse
activation of immune response	GO:0002253	138	0.157
epidermis development	GO:0008544	187	0.155	Worm
regulation of protein serine threonine kinase activity	GO:0071900	157	0.155
ephrin receptor signaling pathway	GO:0048013	20	0.155
myeloid dendritic cell activation involved in immune response	GO:0002277	2	0.155
cell chemotaxis	GO:0060326	81	0.155
immune response activating signal transduction	GO:0002757	116	0.154
nucleoside triphosphate metabolic process	GO:0009141	230	0.152	Mouse
positive regulation of nucleotide catabolic process	GO:0030813	88	0.152
divalent metal ion transport	GO:0070838	172	0.152
cellular response to cytokine stimulus	GO:0071345	189	0.151
g protein coupled receptor signaling pathway	GO:0007186	243	0.151
ensheathment of neurons	GO:0007272	76	0.149
purine containing compound catabolic process	GO:0072523	213	0.147	Mouse
cerebral cortex development	GO:0021987	86	0.147
septum primum development	GO:0003284	4	0.147
cytokine metabolic process	GO:0042107	71	0.146
forebrain development	GO:0030900	302	0.146
regulation of t cell activation	GO:0050863	170	0.146	Mouse
cellular homeostasis	GO:0019725	240	0.146	Mouse
nucleoside triphosphate catabolic process	GO:0009143	205	0.145	Mouse
regulation of secretion	GO:0051046	274	0.145	Mouse
nucleotide metabolic process	GO:0009117	332	0.143	Mouse
purine ribonucleoside triphosphate metabolic process	GO:0009205	220	0.142	Mouse
regulation of lymphocyte activation	GO:0051249	240	0.140	Mouse
extrinsic apoptotic signaling pathway	GO:0097191	126	0.140
positive regulation of gtp catabolic process	GO:0033126	85	0.140
regulation of nucleotide metabolic process	GO:0006140	169	0.140	Mouse
membrane organization	GO:0061024	245	0.139
positive regulation of nucleotide metabolic process	GO:0045981	114	0.139
plasma membrane organization	GO:0007009	90	0.137
leukocyte migration	GO:0050900	124	0.137
regulation of monocyte extravasation	GO:2000437	2	0.135
tumor necrosis factor superfamily cytokine production	GO:0071706	51	0.135
regulation of purine nucleotide metabolic process	GO:1900542	169	0.134	Mouse
stem cell development	GO:0048864	219	0.134
regulation of nucleotide catabolic process	GO:0030811	122	0.132	Mouse
regulation of actin filament based process	GO:0032970	99	0.132	Mouse
aortic valve morphogenesis	GO:0003180	4	0.132
ossification	GO:0001503	216	0.132
mitral valve morphogenesis	GO:0003183	4	0.131
regulation of t cell extravasation	GO:2000407	3	0.131
positive regulation of purine nucleotide metabolic process	GO:1900544	114	0.130
heterocycle catabolic process	GO:0046700	280	0.129	Mouse
positive regulation of cellular amine metabolic process	GO:0033240	5	0.128
kidney development	GO:0001822	213	0.127
positive regulation of map kinase activity	GO:0043406	84	0.127
fasciculation of sensory neuron axon	GO:0097155	3	0.126
regulation of adaptive immune response	GO:0002819	90	0.126
regulation of neuron death	GO:1901214	134	0.126
wound healing	GO:0042060	157	0.124
carbohydrate derivative catabolic process	GO:1901136	231	0.124	Mouse
regulation of neuron apoptotic process	GO:0043523	122	0.123
positive regulation of gtpase activity	GO:0043547	85	0.123
regulation of cellular component biogenesis	GO:0044087	181	0.123
negative regulation of nervous system development	GO:0051961	156	0.123
actin filament organization	GO:0007015	113	0.122
phospholipid metabolic process	GO:0006644	87	0.122
glycosyl compound catabolic process	GO:1901658	206	0.122	Mouse
activation of rho gtpase activity	GO:0032862	7	0.121
positive regulation of cell development	GO:0010720	237	0.120
regulation of glial cell differentiation	GO:0045685	41	0.120
ascending aorta development	GO:0035905	3	0.120
tricuspid valve development	GO:0003175	3	0.120
purine ribonucleoside triphosphate catabolic process	GO:0009207	199	0.119	Mouse
epithelial tube morphogenesis	GO:0060562	303	0.118
innate immune response	GO:0045087	157	0.118
t cell selection	GO:0045058	34	0.118
regulation of cell motility	GO:2000145	236	0.116
ribonucleotide catabolic process	GO:0009261	208	0.115	Mouse
monocyte extravasation	GO:0035696	2	0.115
divalent inorganic cation transport	GO:0072511	178	0.115
urogenital system development	GO:0001655	261	0.114
negative regulation of dendritic spine morphogenesis	GO:0061002	3	0.114
positive regulation of epithelial cell proliferation	GO:0050679	68	0.114
cytokine production	GO:0001816	319	0.113
regulation of rho protein signal transduction	GO:0035023	71	0.113	Mouse
neuron apoptotic process	GO:0051402	142	0.112
cytokine biosynthetic process	GO:0042089	68	0.112
skeletal system development	GO:0001501	356	0.112
positive regulation of striated muscle cell differentiation	GO:0051155	35	0.112	Mouse
cell migration involved in sprouting angiogenesis	GO:0002042	9	0.112
sequestering of metal ion	GO:0051238	19	0.111
wnt signaling pathway	GO:0016055	188	0.109
regulation of protein localization	GO:0032880	231	0.109
regulation of cellular ketone metabolic process	GO:0010565	66	0.108
transmembrane receptor protein tyrosine kinase signaling pathway	GO:0007169	247	0.107
bundle of his development	GO:0003166	4	0.107
regulation of organelle organization	GO:0033043	289	0.106	Mouse
protein localization to organelle	GO:0033365	185	0.106
negative regulation of cellular component organization	GO:0051129	194	0.106
striated muscle tissue development	GO:0014706	293	0.106	Mouse
positive regulation of hydrolase activity	GO:0051345	148	0.105
positive regulation of nervous system development	GO:0051962	221	0.105
purine ribonucleotide catabolic process	GO:0009154	208	0.104	Mouse
telencephalon cell migration	GO:0022029	55	0.104
negative regulation of cell migration	GO:0030336	59	0.104
myeloid leukocyte differentiation	GO:0002573	119	0.104	Mouse
positive regulation of immunological synapse formation	GO:2000522	1	0.102
organonitrogen compound catabolic process	GO:1901565	264	0.102	Mouse
heart morphogenesis	GO:0003007	178	0.101
lymphocyte proliferation	GO:0046651	164	0.101	Mouse
organic cyclic compound catabolic process	GO:1901361	295	0.101	Mouse
inner ear morphogenesis	GO:0042472	101	0.101
positive regulation of transferase activity	GO:0051347	167	0.101
cell type specific apoptotic process	GO:0097285	268	0.100
positive regulation of defense response	GO:0031349	124	0.100
multicellular organismal signaling	GO:0035637	91	0.100
sensory perception of pain	GO:0019233	47	0.099
regulation of transmembrane receptor protein serine threonine kinase signaling pathway	GO:0090092	112	0.098
ribonucleotide metabolic process	GO:0009259	291	0.098	Mouse
cation homeostasis	GO:0055080	212	0.097
lymphocyte migration	GO:0072676	26	0.097
muscle system process	GO:0003012	141	0.096
cell adhesion	GO:0007155	329	0.096	Mouse
axonogenesis	GO:0007409	274	0.095
b cell differentiation	GO:0030183	78	0.095
negative t cell selection	GO:0043383	13	0.095
regulation of protein transport	GO:0051223	163	0.094
striated muscle contraction	GO:0006941	45	0.094
peptide transport	GO:0015833	133	0.094	Mouse
mesenchymal cell development	GO:0014031	93	0.094
regulation of multi organism process	GO:0043900	111	0.093
myeloid dendritic cell activation	GO:0001773	25	0.093
heart process	GO:0003015	94	0.093
ear development	GO:0043583	200	0.091
negative regulation of ovulation	GO:0060280	1	0.091
sequestering of calcium ion	GO:0051208	18	0.090
metal ion homeostasis	GO:0055065	189	0.089
positive regulation of angiogenesis	GO:0045766	46	0.088
glial cell differentiation	GO:0010001	131	0.088
commissural neuron axon guidance	GO:0071679	8	0.088
negative regulation of angiogenesis	GO:0016525	25	0.087
regulation of epithelial cell proliferation	GO:0050678	141	0.087	Mouse
positive regulation of muscle cell differentiation	GO:0051149	39	0.086	Mouse
epithelial cell proliferation	GO:0050673	174	0.086	Mouse
b cell activation	GO:0042113	161	0.085
regulation of homeostatic process	GO:0032844	182	0.085	Mouse
placenta development	GO:0001890	140	0.085
regulation of leukocyte proliferation	GO:0070663	121	0.084	Mouse
regulation of leukocyte differentiation	GO:1902105	159	0.084
fasciculation of motor neuron axon	GO:0097156	2	0.084
ascending aorta morphogenesis	GO:0035910	3	0.084
sensory organ morphogenesis	GO:0090596	242	0.083
positive regulation of protein serine threonine kinase activity	GO:0071902	106	0.082
t cell extravasation	GO:0072683	4	0.082
ventricular septum development	GO:0003281	42	0.081
ribonucleoside triphosphate metabolic process	GO:0009199	220	0.081	Mouse
homeostasis of number of cells	GO:0048872	210	0.080
muscle cell development	GO:0055001	133	0.079
cardiac chamber morphogenesis	GO:0003206	93	0.079
positive regulation of monocyte chemotaxis	GO:0090026	2	0.079
regulation of protein complex assembly	GO:0043254	83	0.078
regulation of cytokine production	GO:0001817	266	0.078
positive regulation of cytokine production	GO:0001819	174	0.078
regulation of anatomical structure size	GO:0090066	178	0.078
mesenchyme development	GO:0060485	152	0.078
organic hydroxy compound metabolic process	GO:1901615	203	0.077
dendrite extension	GO:0097484	3	0.077
purine nucleotide metabolic process	GO:0006163	302	0.077	Mouse
epithelial to mesenchymal transition	GO:0001837	47	0.077
ear morphogenesis	GO:0042471	118	0.076
cytokine mediated signaling pathway	GO:0019221	115	0.076
amide transport	GO:0042886	138	0.076	Mouse
cation transport	GO:0006812	399	0.075
cellular ion homeostasis	GO:0006873	165	0.074
purine containing compound metabolic process	GO:0072521	311	0.074	Mouse
stem cell differentiation	GO:0048863	268	0.073
prevention of polyspermy	GO:0060468	4	0.073
canonical wnt signaling pathway	GO:0060070	130	0.073
cytosolic calcium ion homeostasis	GO:0051480	70	0.073
positive regulation of immune effector process	GO:0002699	107	0.073
tricuspid valve formation	GO:0003195	2	0.072
purine ribonucleotide metabolic process	GO:0009150	290	0.072	Mouse
muscle tissue development	GO:0060537	308	0.071	Mouse
cognition	GO:0050890	149	0.071
glucose homeostasis	GO:0042593	128	0.071	Mouse
neuron migration	GO:0001764	122	0.070
cell migration involved in gastrulation	GO:0042074	13	0.069
germ cell development	GO:0007281	185	0.069
regulation of monocyte chemotaxis	GO:0090025	3	0.069
regulation of endothelial cell migration	GO:0010594	22	0.069
muscle contraction	GO:0006936	101	0.068
regulation of innate immune response	GO:0045088	91	0.068
positive regulation of cd8 positive alpha beta t cell extravasation	GO:2000451	2	0.068
regulation of tumor necrosis factor ligand superfamily member 11 production	GO:2000307	1	0.067
response to molecule of bacterial origin	GO:0002237	143	0.067
interleukin 12 secretion	GO:0072610	3	0.067
cellular response to carbohydrate stimulus	GO:0071322	50	0.067	Mouse
negative regulation of neuron projection regeneration	GO:0070571	3	0.067
cell substrate adhesion	GO:0031589	130	0.067
regulation of tumor necrosis factor superfamily cytokine production	GO:1903555	50	0.066
nephron development	GO:0072006	109	0.066
regulation of cell projection organization	GO:0031344	206	0.066
eosinophil migration	GO:0072677	3	0.066
positive regulation of fibronectin dependent thymocyte migration	GO:2000415	1	0.066
regulation of muscle tissue development	GO:1901861	97	0.066	Mouse
protein localization to nucleus	GO:0034504	121	0.066
regulation of ovulation	GO:0060278	3	0.065
skin development	GO:0043588	220	0.065	Worm
positive regulation of behavior	GO:0048520	40	0.065
leukocyte mediated immunity	GO:0002443	174	0.065
atrial septum primum morphogenesis	GO:0003289	3	0.065
regulation of secretion by cell	GO:1903530	249	0.065	Mouse
cellular response to growth factor stimulus	GO:0071363	197	0.065
parathyroid hormone secretion	GO:0035898	2	0.064
ribonucleoside triphosphate catabolic process	GO:0009203	199	0.063	Mouse
substrate dependent cell migration	GO:0006929	18	0.063
rac protein signal transduction	GO:0016601	13	0.063
adult locomotory behavior	GO:0008344	91	0.063	Mouse
regulation of cellular response to growth factor stimulus	GO:0090287	82	0.063
adaptive immune response based on somatic recombination of immune receptors built from immunoglobulin superfamily domains	GO:0002460	145	0.063
cell adhesion mediated by integrin	GO:0033627	18	0.063
regulation of dendritic spine development	GO:0060998	22	0.062
nephron tubule development	GO:0072080	84	0.062
regulation of cytoplasmic transport	GO:1903649	112	0.062
developmental maturation	GO:0021700	193	0.062
response to oxygen levels	GO:0070482	62	0.062
regulation of immune complex clearance by monocytes and macrophages	GO:0090264	2	0.062
notochord development	GO:0030903	20	0.061
positive regulation of acute inflammatory response	GO:0002675	16	0.061
extracellular matrix dependent thymocyte migration	GO:0072680	1	0.060
response to acid chemical	GO:0001101	111	0.060
cd8 positive alpha beta t cell extravasation	GO:0035697	3	0.060
endothelial cell migration	GO:0043542	44	0.060
leukocyte proliferation	GO:0070661	172	0.060	Mouse
endodermal cell fate specification	GO:0001714	4	0.060
immune response regulating cell surface receptor signaling pathway	GO:0002768	80	0.060
positive regulation of programmed cell death	GO:0043068	218	0.060
positive regulation of transmembrane receptor protein serine threonine kinase signaling pathway	GO:0090100	43	0.060
regulation of stem cell proliferation	GO:0072091	78	0.060
tube formation	GO:0035148	140	0.060
purine nucleoside catabolic process	GO:0006152	205	0.059	Mouse
positive thymic t cell selection	GO:0045059	13	0.059
positive regulation of immune complex clearance by monocytes and macrophages	GO:0090265	2	0.058
transmembrane receptor protein serine threonine kinase signaling pathway	GO:0007178	194	0.058
regulation of heart contraction	GO:0008016	77	0.058
regulation of cell adhesion	GO:0030155	154	0.058	Mouse
mesenchymal cell differentiation	GO:0048762	107	0.058
regulation of eosinophil migration	GO:2000416	2	0.058
leukocyte chemotaxis	GO:0030595	69	0.058
glycosyl compound metabolic process	GO:1901657	246	0.058	Mouse
cardiac muscle contraction	GO:0060048	32	0.058
regulation of intracellular transport	GO:0032386	159	0.057
regulation of epithelial to mesenchymal transition	GO:0010717	22	0.057
release of sequestered calcium ion into cytosol	GO:0051209	42	0.057
apoptotic signaling pathway	GO:0097190	306	0.057
sprouting angiogenesis	GO:0002040	26	0.057
single organism cell adhesion	GO:0098602	156	0.057	Mouse
digestive tract morphogenesis	GO:0048546	147	0.056
regulation of kinase activity	GO:0043549	249	0.056
nucleobase containing small molecule metabolic process	GO:0055086	352	0.056	Mouse
positive regulation of apoptotic process	GO:0043065	217	0.056
regulation of sequence specific dna binding transcription factor activity	GO:0051090	106	0.056
gland development	GO:0048732	330	0.055
humoral immune response	GO:0006959	57	0.054
single organism nuclear import	GO:1902593	95	0.054
regulation of defense response	GO:0031347	233	0.054
activation of mapk activity	GO:0000187	59	0.054
regulation of positive chemotaxis	GO:0050926	7	0.053
regulation of vesicle mediated transport	GO:0060627	139	0.053
pulmonary valve development	GO:0003177	5	0.053
heart trabecula formation	GO:0060347	14	0.053
digestive tract development	GO:0048565	190	0.053
positive regulation of cell migration	GO:0030335	109	0.053
activation of ras gtpase activity	GO:0032856	11	0.052
calcium ion transport into cytosol	GO:0060402	48	0.052
maintenance of location	GO:0051235	89	0.052
cochlea development	GO:0090102	35	0.052
regulation of cellular component size	GO:0032535	121	0.052
positive regulation of t cell proliferation	GO:0042102	52	0.052	Mouse
asymmetric neuroblast division	GO:0055059	1	0.052
fibronectin dependent thymocyte migration	GO:0072681	1	0.051
ventricular septum morphogenesis	GO:0060412	27	0.051
sensory organ boundary specification	GO:0008052	1	0.051
regulation of t cell costimulation	GO:2000523	2	0.051
regulation of blood circulation	GO:1903522	93	0.050
negative regulation of phosphorylation	GO:0042326	166	0.050
palate development	GO:0060021	76	0.050
morphogenesis of a branching epithelium	GO:0061138	193	0.050
myelination in peripheral nervous system	GO:0022011	19	0.050
positive regulation of t cell extravasation	GO:2000409	2	0.049
positive regulation of monocyte extravasation	GO:2000439	1	0.049
regulation of immunological synapse formation	GO:2000520	2	0.049
transmission of nerve impulse	GO:0019226	76	0.049
cardioblast migration to the midline involved in heart field formation	GO:0060975	1	0.049
kidney morphogenesis	GO:0060993	83	0.049
regulation of cytokine biosynthetic process	GO:0042035	59	0.049
negative regulation of apoptotic signaling pathway	GO:2001234	104	0.049
labyrinthine layer blood vessel development	GO:0060716	21	0.048
formation of organ boundary	GO:0010160	1	0.048
positive regulation of cytosolic calcium ion concentration	GO:0007204	65	0.048
regulation of insulin secretion involved in cellular response to glucose stimulus	GO:0061178	31	0.048	Mouse
eosinophil activation involved in immune response	GO:0002278	1	0.048
negative regulation of immune system process	GO:0002683	209	0.048
regulation of cell cycle	GO:0051726	281	0.048
positive regulation of cell adhesion	GO:0045785	80	0.048
dendritic spine development	GO:0060996	30	0.048
cellular component assembly involved in morphogenesis	GO:0010927	139	0.048
production of molecular mediator of immune response	GO:0002440	103	0.048
myeloid cell apoptotic process	GO:0033028	22	0.047
positive regulation of t cell costimulation	GO:2000525	2	0.047
fertilization	GO:0009566	127	0.047
retinal blood vessel morphogenesis	GO:0061304	3	0.047
regulation of striated muscle cell differentiation	GO:0051153	81	0.047	Mouse
hematopoietic progenitor cell differentiation	GO:0002244	143	0.046
epithelium migration	GO:0090132	63	0.046
aromatic compound catabolic process	GO:0019439	286	0.046	Mouse
positive regulation of kinase activity	GO:0033674	155	0.046
cellular glucose homeostasis	GO:0001678	52	0.046	Mouse
regulation of ras protein signal transduction	GO:0046578	114	0.046	Mouse
negative regulation of wnt signaling pathway involved in heart development	GO:0003308	4	0.046
nuclear transport	GO:0051169	139	0.046
membrane raft organization	GO:0031579	5	0.046
macrophage activation	GO:0042116	27	0.046
regulation of inflammatory response	GO:0050727	147	0.045
actin filament based movement	GO:0030048	23	0.045
t cell migration	GO:0072678	19	0.045
regulation of apoptotic signaling pathway	GO:2001233	197	0.045
positive regulation of intracellular transport	GO:0032388	70	0.045
regulation of protein import into nucleus	GO:0042306	52	0.045
neuronal action potential	GO:0019228	54	0.044
regulation of dendritic cell chemotaxis	GO:2000508	1	0.044
cell fate commitment	GO:0045165	210	0.044
leukocyte apoptotic process	GO:0071887	71	0.044
neuroblast proliferation	GO:0007405	49	0.044
neural tube development	GO:0021915	160	0.044
regulation of dendritic spine morphogenesis	GO:0061001	17	0.044
positive regulation of cell motility	GO:2000147	116	0.044
purine nucleoside triphosphate catabolic process	GO:0009146	203	0.044	Mouse
embryonic epithelial tube formation	GO:0001838	130	0.044
regulation of metal ion transport	GO:0010959	106	0.044
cellular response to lipopolysaccharide	GO:0071222	77	0.043
embryonic placenta development	GO:0001892	98	0.043
myelination	GO:0042552	74	0.043
endocytosis	GO:0006897	168	0.043
microglial cell activation	GO:0001774	3	0.043
endocardial cushion development	GO:0003197	26	0.043
purine ribonucleoside metabolic process	GO:0046128	241	0.042	Mouse
cellular metal ion homeostasis	GO:0006875	151	0.042
nephron epithelium morphogenesis	GO:0072088	68	0.042
regulation of antigen receptor mediated signaling pathway	GO:0050854	29	0.042
negative regulation of macrophage apoptotic process	GO:2000110	3	0.042
sensory perception	GO:0007600	245	0.042
pulmonary valve morphogenesis	GO:0003184	5	0.042
cell migration to the midline involved in heart development	GO:0003318	1	0.042
cellular response to biotic stimulus	GO:0071216	92	0.042
insulin secretion	GO:0030073	89	0.041	Mouse
regulation of auditory receptor cell differentiation	GO:0045607	4	0.041
mesonephric tubule development	GO:0072164	94	0.041
insulin secretion involved in cellular response to glucose stimulus	GO:0035773	36	0.041	Mouse
peptide hormone secretion	GO:0030072	109	0.041	Mouse
branching morphogenesis of an epithelial tube	GO:0048754	159	0.041
positive regulation of organelle organization	GO:0010638	128	0.041
endocrine process	GO:0050886	39	0.040
regionalization	GO:0003002	337	0.040
regulation of ion transport	GO:0043269	215	0.040
regulation of map kinase activity	GO:0043405	120	0.040
macromolecule catabolic process	GO:0009057	281	0.040
regulation of endothelial cell proliferation	GO:0001936	23	0.040
regulation of cd8 positive alpha beta t cell extravasation	GO:2000449	3	0.040
protein kinase b signaling	GO:0043491	74	0.040
lateral line system development	GO:0048925	1	0.040
positive regulation of inflammatory response	GO:0050729	47	0.040
negative regulation of immune effector process	GO:0002698	55	0.040
nitrogen compound transport	GO:0071705	271	0.040	Mouse
endothelial cell proliferation	GO:0001935	27	0.040
dendritic spine morphogenesis	GO:0060997	22	0.040

Efna1 disease predictions

Disease predictions are made from cross-annotation of human disease genes to the identified functional analogs in mouse and predicted with the mouse functional network.

Disease	DO term ID	Probability
heart disease	DOID:114	0.340
disease of anatomical entity	DOID:7	0.340
cardiovascular system disease	DOID:1287	0.340
muscular disease	DOID:0080000	0.045
musculoskeletal system disease	DOID:17	0.045

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