IMP: Integrative Multi-species Prediction

Mus musculus

0 known processes

Sema3b

sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3B

(Aliases: AW208495,LUCA-1,sema5,semaV,SemA,Semaa)

Entrez: 20347
Ensembl: ENSMUSG00000057969
UniProtKB: M9MMK0
UniProtKB: Q0VGP2

Process Predictions
Disease Predictions

Sema3b biological process predictions

Show only novel predictionsHighlight processes of functional analogs

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Biological process	GO term ID	Process size	Probability	Func Analog Org
cell adhesion	GO:0007155	329	0.584	Worm
cell substrate adhesion	GO:0031589	130	0.534
branching morphogenesis of an epithelial tube	GO:0048754	159	0.464
ion transmembrane transport	GO:0034220	361	0.448
purine nucleoside metabolic process	GO:0042278	241	0.434	Mouse
sensory organ morphogenesis	GO:0090596	242	0.424
camera type eye development	GO:0043010	266	0.421
actin filament organization	GO:0007015	113	0.416
cellular amino acid metabolic process	GO:0006520	103	0.413
transmembrane transport	GO:0055085	412	0.400
regulation of cell substrate adhesion	GO:0010810	73	0.376
developmental maturation	GO:0021700	193	0.371	Mouse
regulation of cell motility	GO:2000145	236	0.365	Mouse Worm
nucleobase containing small molecule metabolic process	GO:0055086	352	0.344	Mouse
inorganic ion transmembrane transport	GO:0098660	234	0.341
cellular amine metabolic process	GO:0044106	44	0.338
regulation of hydrolase activity	GO:0051336	246	0.334	Mouse
cation transport	GO:0006812	399	0.323
nucleoside phosphate metabolic process	GO:0006753	338	0.317	Mouse
cation transmembrane transport	GO:0098655	266	0.311
digestive tract development	GO:0048565	190	0.297
nucleoside triphosphate metabolic process	GO:0009141	230	0.297	Mouse
guanosine containing compound metabolic process	GO:1901068	144	0.296	Mouse
regulation of cellular amine metabolic process	GO:0033238	20	0.291
regulation of body fluid levels	GO:0050878	162	0.291
urogenital system development	GO:0001655	261	0.290
skeletal muscle organ development	GO:0060538	163	0.288
ossification	GO:0001503	216	0.286	Mouse
negative regulation of phosphate metabolic process	GO:0045936	184	0.285	Mouse
nucleoside triphosphate catabolic process	GO:0009143	205	0.279	Mouse
guanosine containing compound catabolic process	GO:1901069	144	0.265	Mouse
ras protein signal transduction	GO:0007265	77	0.262
renal system development	GO:0072001	225	0.260
organic hydroxy compound metabolic process	GO:1901615	203	0.257
muscle cell differentiation	GO:0042692	261	0.255	Mouse
transmembrane receptor protein tyrosine kinase signaling pathway	GO:0007169	247	0.254
purine ribonucleoside triphosphate metabolic process	GO:0009205	220	0.254	Mouse
regulation of transmembrane receptor protein serine threonine kinase signaling pathway	GO:0090092	112	0.251
purine ribonucleotide metabolic process	GO:0009150	290	0.249	Mouse
cation homeostasis	GO:0055080	212	0.244
regulation of cellular catabolic process	GO:0031329	242	0.244	Mouse
gtp metabolic process	GO:0046039	144	0.239	Mouse
regulation of protein localization	GO:0032880	231	0.239
kidney development	GO:0001822	213	0.237
mesonephric duct morphogenesis	GO:0072180	4	0.236
ameboidal type cell migration	GO:0001667	128	0.232	Mouse
nephron epithelium morphogenesis	GO:0072088	68	0.232
mesonephric duct formation	GO:0072181	2	0.229
regulation of cytoskeleton organization	GO:0051493	122	0.223	Worm
negative regulation of synapse assembly	GO:0051964	3	0.223
leukocyte differentiation	GO:0002521	342	0.221	Mouse
morphogenesis of a polarized epithelium	GO:0001738	37	0.219
single organismal cell cell adhesion	GO:0016337	131	0.217
organonitrogen compound catabolic process	GO:1901565	264	0.213	Mouse
renal outer medulla development	GO:0072054	2	0.210
regulation of cellular response to stress	GO:0080135	159	0.208
nucleoside catabolic process	GO:0009164	206	0.206	Mouse
blood vessel morphogenesis	GO:0048514	285	0.205	Mouse
glycosyl compound metabolic process	GO:1901657	246	0.205	Mouse
small gtpase mediated signal transduction	GO:0007264	97	0.203
membrane organization	GO:0061024	245	0.202
cell matrix adhesion	GO:0007160	68	0.201
morphogenesis of embryonic epithelium	GO:0016331	159	0.200	Mouse Worm
forebrain development	GO:0030900	302	0.199	Mouse
neuron projection guidance	GO:0097485	141	0.197	Mouse Worm Fly
single organism cell adhesion	GO:0098602	156	0.197
positive regulation of cell adhesion	GO:0045785	80	0.197
gtp catabolic process	GO:0006184	143	0.195	Mouse
morphogenesis of a branching epithelium	GO:0061138	193	0.193	Mouse
epithelial cell proliferation	GO:0050673	174	0.193
myoblast differentiation involved in skeletal muscle regeneration	GO:0014835	3	0.193
purine ribonucleoside catabolic process	GO:0046130	205	0.192	Mouse
axonogenesis	GO:0007409	274	0.192	Mouse Worm Fly
actin cytoskeleton organization	GO:0030036	220	0.191	Worm
protein localization to membrane	GO:0072657	108	0.189
exocrine system development	GO:0035272	45	0.187	Mouse Fly
planar cell polarity pathway involved in pericardium morphogenesis	GO:0061354	2	0.186
polarity specification of proximal distal axis	GO:0010085	2	0.184
purine ribonucleoside triphosphate catabolic process	GO:0009207	199	0.183	Mouse
ribonucleotide metabolic process	GO:0009259	291	0.181	Mouse
planar cell polarity pathway involved in outflow tract morphogenesis	GO:0061347	2	0.181
ribonucleoside metabolic process	GO:0009119	245	0.180	Mouse
nephron morphogenesis	GO:0072028	69	0.180
sensory perception	GO:0007600	245	0.174
kidney epithelium development	GO:0072073	121	0.172
nucleotide catabolic process	GO:0009166	217	0.171	Mouse
negative regulation of cell proliferation	GO:0008285	296	0.169
heart morphogenesis	GO:0003007	178	0.167
anion transport	GO:0006820	177	0.166
negative regulation of neuron projection development	GO:0010977	50	0.166	Mouse
cellular ketone metabolic process	GO:0042180	84	0.166
nephron tubule development	GO:0072080	84	0.164
purine containing compound metabolic process	GO:0072521	311	0.164	Mouse
amine metabolic process	GO:0009308	45	0.163
cell type specific apoptotic process	GO:0097285	268	0.162
cell maturation	GO:0048469	127	0.162
ribose phosphate metabolic process	GO:0019693	291	0.160	Mouse
positive regulation of cell cell adhesion mediated by cadherin	GO:2000049	2	0.159
purine nucleoside catabolic process	GO:0006152	205	0.159	Mouse
epithelial cell morphogenesis	GO:0003382	41	0.158
cell cell junction organization	GO:0045216	72	0.158
circulatory system process	GO:0003013	197	0.157	Mouse
cell fate commitment	GO:0045165	210	0.157
ribonucleotide catabolic process	GO:0009261	208	0.156	Mouse
protein localization to plasma membrane	GO:0072659	57	0.156
wnt signaling pathway involved in forebrain neuroblast division	GO:0021874	2	0.156
appendage development	GO:0048736	166	0.155
digestive system development	GO:0055123	200	0.155
tube formation	GO:0035148	140	0.154	Mouse
carbohydrate derivative catabolic process	GO:1901136	231	0.154	Mouse
regulation of organelle organization	GO:0033043	289	0.153	Worm
positive regulation of protein modification process	GO:0031401	299	0.151	Mouse
positive regulation of growth	GO:0045927	104	0.151
plasma membrane organization	GO:0007009	90	0.151
morphogenesis of a branching structure	GO:0001763	203	0.150	Mouse
muscle contraction	GO:0006936	101	0.149
purine nucleoside triphosphate metabolic process	GO:0009144	226	0.149	Mouse
epithelial cell development	GO:0002064	159	0.148
planar cell polarity pathway involved in ventricular septum morphogenesis	GO:0061348	2	0.146
positive regulation of interleukin 8 secretion	GO:2000484	1	0.144
central nervous system vasculogenesis	GO:0022009	3	0.141
regulation of gtp catabolic process	GO:0033124	113	0.141	Mouse
epithelial cell migration	GO:0010631	63	0.140	Mouse
central nervous system morphogenesis	GO:0021551	2	0.140
nucleoside metabolic process	GO:0009116	246	0.139	Mouse
positive regulation of cellular amine metabolic process	GO:0033240	5	0.139
bmp signaling pathway	GO:0030509	93	0.138
regulation of rna polymerase ii transcriptional preinitiation complex assembly	GO:0045898	2	0.138
regulation of synaptic growth at neuromuscular junction	GO:0008582	4	0.138
regulation of canonical wnt signaling pathway involved in controlling type b pancreatic cell proliferation	GO:2000079	1	0.136
blastocyst development	GO:0001824	80	0.135
regulation of anagen	GO:0051884	1	0.135
regulation of secretion by cell	GO:1903530	249	0.135
aromatic compound catabolic process	GO:0019439	286	0.133	Mouse
regulation of nucleotide catabolic process	GO:0030811	122	0.132	Mouse
tertiary branching involved in mammary gland duct morphogenesis	GO:0060748	3	0.131
positive regulation of neuron differentiation	GO:0045666	141	0.131	Mouse
ribonucleoside triphosphate metabolic process	GO:0009199	220	0.130	Mouse
positive regulation of cellular amino acid metabolic process	GO:0045764	3	0.130
canonical wnt signaling pathway involved in regulation of cell proliferation	GO:0044340	3	0.129
regulation of proteolysis	GO:0030162	164	0.129
nitrogen compound transport	GO:0071705	271	0.129
lung development	GO:0030324	164	0.128
oviduct development	GO:0060066	3	0.127
ribonucleoside catabolic process	GO:0042454	206	0.127	Mouse
purine nucleoside triphosphate catabolic process	GO:0009146	203	0.126	Mouse
positive regulation of cell cycle	GO:0045787	92	0.126
cell junction organization	GO:0034330	77	0.125
regulation of cell adhesion	GO:0030155	154	0.125	Worm
regulation of establishment of planar polarity	GO:0090175	28	0.125
epithelial tube morphogenesis	GO:0060562	303	0.124	Mouse
maintenance of cell number	GO:0098727	3	0.124
regulation of purine nucleotide catabolic process	GO:0033121	122	0.124	Mouse
synapse organization	GO:0050808	125	0.124
negative regulation of cell development	GO:0010721	169	0.124	Mouse
regulation of system process	GO:0044057	200	0.124	Mouse
organic cyclic compound catabolic process	GO:1901361	295	0.123	Mouse
positive regulation of protein phosphorylation	GO:0001934	242	0.121	Mouse
blood circulation	GO:0008015	195	0.121	Mouse
paraxial mesodermal cell fate commitment	GO:0048343	2	0.120
regulation of transmembrane transport	GO:0034762	128	0.120
positive regulation of hydrolase activity	GO:0051345	148	0.119	Mouse
regulation of nucleoside metabolic process	GO:0009118	130	0.119	Mouse
purine nucleotide catabolic process	GO:0006195	211	0.119	Mouse
purine ribonucleoside metabolic process	GO:0046128	241	0.119	Mouse
regulation of purine nucleotide metabolic process	GO:1900542	169	0.118	Mouse
cell junction assembly	GO:0034329	52	0.118
regulation of testosterone biosynthetic process	GO:2000224	2	0.117
establishment of protein localization to plasma membrane	GO:0090002	34	0.117
nephron tubule morphogenesis	GO:0072078	68	0.117
regulation of intracellular protein transport	GO:0033157	82	0.117
thyroid stimulating hormone secreting cell differentiation	GO:0060129	4	0.116
glycosyl compound catabolic process	GO:1901658	206	0.116	Mouse
outer medullary collecting duct development	GO:0072060	1	0.115
regulation of synaptic plasticity	GO:0048167	87	0.115
striated muscle cell development	GO:0055002	125	0.114
regulation of epithelial cell proliferation	GO:0050678	141	0.114
skeletal muscle satellite cell maintenance involved in skeletal muscle regeneration	GO:0014834	3	0.114
regulation of nucleotide metabolic process	GO:0006140	169	0.114	Mouse
ribonucleoside triphosphate catabolic process	GO:0009203	199	0.113	Mouse
regulation of actin filament based process	GO:0032970	99	0.113	Worm
positive regulation of anagen	GO:0051885	1	0.110
gas homeostasis	GO:0033483	3	0.110
rho protein signal transduction	GO:0007266	32	0.110
regulation of mitotic cell cycle	GO:0007346	126	0.109
heterocycle catabolic process	GO:0046700	280	0.108	Mouse
positive regulation of gtpase activity	GO:0043547	85	0.108	Mouse
mesonephric tubule morphogenesis	GO:0072171	63	0.108
apoptotic signaling pathway	GO:0097190	306	0.108
regulation of rho gtpase activity	GO:0032319	58	0.107	Mouse
positive regulation of kinase activity	GO:0033674	155	0.107
regulation of cysteine type endopeptidase activity	GO:2000116	65	0.107
nephron epithelium development	GO:0072009	92	0.107
regionalization	GO:0003002	337	0.107	Mouse
regulation of ras protein signal transduction	GO:0046578	114	0.106	Mouse
transmembrane receptor protein serine threonine kinase signaling pathway	GO:0007178	194	0.106
paraxial mesodermal cell differentiation	GO:0048342	2	0.106
angiogenesis	GO:0001525	201	0.106	Mouse
protein catabolic process	GO:0030163	221	0.106
amide transport	GO:0042886	138	0.106
regulation of peptidase activity	GO:0052547	96	0.105
regulation of protein transport	GO:0051223	163	0.105
organophosphate catabolic process	GO:0046434	232	0.105	Mouse
planar cell polarity pathway involved in cardiac right atrium morphogenesis	GO:0061349	2	0.105
extracellular matrix organization	GO:0030198	147	0.105
planar cell polarity pathway involved in cardiac muscle tissue morphogenesis	GO:0061350	2	0.104
establishment of organ orientation	GO:0048561	1	0.104
actomyosin structure organization	GO:0031032	56	0.104
actin filament bundle assembly	GO:0051017	40	0.104
stem cell differentiation	GO:0048863	268	0.104	Mouse
regulation of cellular amino acid metabolic process	GO:0006521	5	0.104
positive regulation of map kinase activity	GO:0043406	84	0.104
protein localization to organelle	GO:0033365	185	0.103
regulation of secretion	GO:0051046	274	0.102
organic hydroxy compound transport	GO:0015850	93	0.102
canonical wnt signaling pathway involved in regulation of type b pancreatic cell proliferation	GO:0044343	1	0.101
positive regulation of epithelial cell proliferation involved in lung morphogenesis	GO:0060501	3	0.101
midbrain hindbrain boundary maturation during brain development	GO:0022004	1	0.100
endothelial cell migration	GO:0043542	44	0.099	Mouse
nucleoside phosphate catabolic process	GO:1901292	222	0.099	Mouse
regulation of kinase activity	GO:0043549	249	0.099
cellular response to acid chemical	GO:0071229	68	0.099
muscle system process	GO:0003012	141	0.099
hindbrain formation	GO:0021576	1	0.099
embryonic appendage morphogenesis	GO:0035113	126	0.099
regulation of mapk cascade	GO:0043408	248	0.098
regulation of apoptotic signaling pathway	GO:2001233	197	0.098
muscle cell development	GO:0055001	133	0.098
regulation of establishment of protein localization	GO:0070201	181	0.098
regulation of ion transmembrane transport	GO:0034765	119	0.097
calcium ion homeostasis	GO:0055074	127	0.097
lateral sprouting involved in mammary gland duct morphogenesis	GO:0060599	2	0.097
cell growth	GO:0016049	130	0.096	Mouse
canonical wnt signaling pathway	GO:0060070	130	0.096
regulation of cellular ketone metabolic process	GO:0010565	66	0.096
positive regulation of apoptotic process	GO:0043065	217	0.095
purine nucleotide metabolic process	GO:0006163	302	0.095	Mouse
negative regulation of testosterone biosynthetic process	GO:2000225	1	0.095
branching involved in ureteric bud morphogenesis	GO:0001658	56	0.094
midbrain hindbrain boundary maturation	GO:0021732	1	0.094
regulation of cell migration	GO:0030334	219	0.094	Mouse Worm
regulation of ras gtpase activity	GO:0032318	88	0.094	Mouse
intracellular protein transport	GO:0006886	204	0.094
regulation of bmp signaling pathway	GO:0030510	60	0.094
midgut development	GO:0007494	4	0.092
maintenance of location	GO:0051235	89	0.092
renal tubule development	GO:0061326	87	0.092
positive regulation of protein kinase activity	GO:0045860	144	0.092
retinal blood vessel morphogenesis	GO:0061304	3	0.091
uterus morphogenesis	GO:0061038	2	0.091
locomotory behavior	GO:0007626	195	0.091	Fly
positive regulation of canonical wnt signaling pathway involved in controlling type b pancreatic cell proliferation	GO:2000081	1	0.090
salivary gland morphogenesis	GO:0007435	33	0.090	Mouse
renal tubule morphogenesis	GO:0061333	72	0.090
mitotic cell cycle	GO:0000278	195	0.090
lung induction	GO:0060492	3	0.090
nephric duct formation	GO:0072179	4	0.089
mapk cascade	GO:0000165	281	0.089
kidney morphogenesis	GO:0060993	83	0.089
cellular divalent inorganic cation homeostasis	GO:0072503	127	0.087
embryonic placenta development	GO:0001892	98	0.087
positive regulation of nucleoside metabolic process	GO:0045979	91	0.087	Mouse
non canonical wnt signaling pathway via jnk cascade	GO:0038031	3	0.087
chemotaxis	GO:0006935	247	0.087	Mouse Worm Fly
regulation of cellular component biogenesis	GO:0044087	181	0.086
regulation of cell projection organization	GO:0031344	206	0.086	Mouse
mesoderm development	GO:0007498	100	0.086
branching involved in salivary gland morphogenesis	GO:0060445	26	0.085	Mouse
developmental growth involved in morphogenesis	GO:0060560	138	0.085	Mouse
organic anion transport	GO:0015711	137	0.085
positive regulation of proteolysis	GO:0045862	85	0.084
trachea cartilage morphogenesis	GO:0060535	4	0.084
renal vesicle induction	GO:0072034	3	0.084
pallium development	GO:0021543	120	0.084	Mouse
response to nutrient levels	GO:0031667	109	0.083
appendage morphogenesis	GO:0035107	149	0.083
metanephric glomerular basement membrane development	GO:0072274	1	0.083
metanephros development	GO:0001656	79	0.083
wnt signaling pathway	GO:0016055	188	0.083
metal ion homeostasis	GO:0055065	189	0.083
endomembrane system organization	GO:0010256	147	0.083
divalent inorganic cation transport	GO:0072511	178	0.082
cardiac right atrium morphogenesis	GO:0003213	3	0.082
stem cell development	GO:0048864	219	0.082	Mouse
bone mineralization	GO:0030282	54	0.082
negative regulation of phosphorus metabolic process	GO:0010563	184	0.082	Mouse
microtubule based process	GO:0007017	236	0.082
muscle tissue development	GO:0060537	308	0.081
positive regulation of mapk cascade	GO:0043410	170	0.081
ubiquitin dependent smad protein catabolic process	GO:0030579	2	0.081
positive regulation of branching involved in lung morphogenesis	GO:0061047	4	0.081
regulation of endopeptidase activity	GO:0052548	89	0.081
embryonic epithelial tube formation	GO:0001838	130	0.080	Mouse
epithelial tube formation	GO:0072175	130	0.080	Mouse
ureteric bud development	GO:0001657	94	0.080
peptide transport	GO:0015833	133	0.080
positive regulation of purine nucleotide catabolic process	GO:0033123	88	0.080	Mouse
regulation of neuron apoptotic process	GO:0043523	122	0.079
cognition	GO:0050890	149	0.079
cellular metal ion homeostasis	GO:0006875	151	0.079
regulation of cell activation	GO:0050865	289	0.079
oxygen homeostasis	GO:0032364	2	0.079
positive regulation of peptidase activity	GO:0010952	49	0.078
brain morphogenesis	GO:0048854	32	0.077
respiratory system development	GO:0060541	190	0.077
gland development	GO:0048732	330	0.076	Mouse Fly
respiratory tube development	GO:0030323	167	0.076
regulation of neuron differentiation	GO:0045664	281	0.076	Mouse
establishment of planar polarity	GO:0001736	28	0.076
endocytosis	GO:0006897	168	0.076
positive regulation of protein transport	GO:0051222	93	0.075
cellular homeostasis	GO:0019725	240	0.075
tissue remodeling	GO:0048771	102	0.075
cardiac muscle tissue development	GO:0048738	130	0.075
spemann organizer formation	GO:0060061	2	0.075
negative regulation of androgen biosynthetic process	GO:2000180	1	0.074
establishment of planar polarity involved in nephron morphogenesis	GO:0072046	1	0.074
cellular nitrogen compound catabolic process	GO:0044270	280	0.074	Mouse
multicellular organismal signaling	GO:0035637	91	0.074
neuron projection extension	GO:1990138	64	0.074	Mouse
hypophysis morphogenesis	GO:0048850	3	0.074
morphogenesis of an epithelial sheet	GO:0002011	27	0.073
embryonic limb morphogenesis	GO:0030326	126	0.073
regulation of cell cycle	GO:0051726	281	0.073
regulation of cysteine type endopeptidase activity involved in apoptotic process	GO:0043281	62	0.073
establishment of anatomical structure orientation	GO:0048560	1	0.072
regulation of chemotaxis	GO:0050920	53	0.072	Mouse
ureteric bud morphogenesis	GO:0060675	62	0.071
positive regulation of nucleotide catabolic process	GO:0030813	88	0.071	Mouse
positive regulation of nervous system development	GO:0051962	221	0.071	Mouse
smooth muscle contraction	GO:0006939	44	0.071
purine ribonucleotide catabolic process	GO:0009154	208	0.070	Mouse
cellular ion homeostasis	GO:0006873	165	0.070
outflow tract morphogenesis	GO:0003151	53	0.070
regulation of axon extension	GO:0030516	43	0.070	Mouse
cartilage development	GO:0051216	140	0.070
ear development	GO:0043583	200	0.070
limbic system development	GO:0021761	72	0.069	Mouse
positive regulation of stem cell proliferation	GO:2000648	59	0.069
positive regulation of transforming growth factor beta2 production	GO:0032915	2	0.069
metanephric nephron development	GO:0072210	34	0.069
positive regulation of organelle organization	GO:0010638	128	0.069
gastrulation	GO:0007369	116	0.069
regulation of intracellular transport	GO:0032386	159	0.068
regulation of ion transport	GO:0043269	215	0.068
positive regulation of rho gtpase activity	GO:0032321	41	0.068	Mouse
specification of organ identity	GO:0010092	30	0.068
cellular response to growth factor stimulus	GO:0071363	197	0.068
epithelium migration	GO:0090132	63	0.068	Mouse
response to transforming growth factor beta	GO:0071559	88	0.068
connective tissue development	GO:0061448	179	0.067
lipid biosynthetic process	GO:0008610	179	0.067
protein maturation	GO:0051604	176	0.067
digestive tract morphogenesis	GO:0048546	147	0.067
regulation of actin cytoskeleton organization	GO:0032956	84	0.066	Worm
regulation of neuron death	GO:1901214	134	0.066
limb development	GO:0060173	166	0.066
nephron tubule formation	GO:0072079	20	0.066
regulation of cellular response to growth factor stimulus	GO:0090287	82	0.066
establishment of protein localization to membrane	GO:0090150	54	0.066
positive regulation of cell substrate adhesion	GO:0010811	47	0.066
neuromuscular process	GO:0050905	99	0.066
monocarboxylic acid metabolic process	GO:0032787	191	0.065
cytoplasmic transport	GO:0016482	234	0.065
regulation of epithelial cell migration	GO:0010632	35	0.065	Mouse
protein localization to nucleus	GO:0034504	121	0.065
regulation of organ morphogenesis	GO:2000027	144	0.065
positive regulation of potassium ion transport	GO:0043268	3	0.064
response to inorganic substance	GO:0010035	96	0.064
telencephalon development	GO:0021537	186	0.064	Mouse
skeletal system development	GO:0001501	356	0.064	Mouse
wnt signaling pathway calcium modulating pathway	GO:0007223	2	0.064
primary neural tube formation	GO:0014020	95	0.064	Mouse
chondrocyte differentiation	GO:0002062	72	0.064
anion transmembrane transport	GO:0098656	71	0.063
cellular response to transforming growth factor beta stimulus	GO:0071560	88	0.063
foregut regionalization	GO:0060423	3	0.063
regulation of ketone biosynthetic process	GO:0010566	2	0.063
positive regulation of purine nucleotide metabolic process	GO:1900544	114	0.063	Mouse
retina development in camera type eye	GO:0060041	119	0.063
transforming growth factor beta receptor signaling pathway	GO:0007179	71	0.062
fibroblast growth factor receptor signaling pathway	GO:0008543	46	0.062
positive regulation of cellular catabolic process	GO:0031331	148	0.062	Mouse
establishment of planar polarity involved in neural tube closure	GO:0090177	15	0.062
mesonephric tubule formation	GO:0072172	11	0.062
divalent inorganic cation homeostasis	GO:0072507	138	0.062
neural tube development	GO:0021915	160	0.062	Mouse
purine containing compound catabolic process	GO:0072523	213	0.061	Mouse
inner medullary collecting duct development	GO:0072061	2	0.061
positive regulation of transcription from rna polymerase ii promoter involved in smooth muscle cell differentiation	GO:2000721	2	0.061
embryonic organ morphogenesis	GO:0048562	276	0.061
neurotransmitter transport	GO:0006836	76	0.061
neuron apoptotic process	GO:0051402	142	0.061
stem cell proliferation	GO:0072089	117	0.060
planar cell polarity pathway involved in heart morphogenesis	GO:0061346	3	0.060
cerebellum formation	GO:0021588	1	0.060
developmental programmed cell death	GO:0010623	41	0.060
spemann organizer formation at the anterior end of the primitive streak	GO:0060064	1	0.060
establishment of tissue polarity	GO:0007164	28	0.060
regulation of fibroblast growth factor production	GO:0090270	4	0.059
protein targeting	GO:0006605	143	0.058
negative regulation of bmp signaling pathway	GO:0030514	35	0.058
regulation of ossification	GO:0030278	112	0.058	Mouse
regulation of cell morphogenesis involved in differentiation	GO:0010769	151	0.058	Mouse
photoreceptor cell differentiation	GO:0046530	52	0.058
negative regulation of cell motility	GO:2000146	61	0.057	Mouse
sodium ion export	GO:0071436	2	0.057
lipid transport	GO:0006869	98	0.057
axon guidance	GO:0007411	141	0.056	Mouse Worm Fly
organonitrogen compound biosynthetic process	GO:1901566	192	0.056
peptidyl amino acid modification	GO:0018193	336	0.056	Mouse
mesonephric epithelium development	GO:0072163	94	0.056
myotube differentiation	GO:0014902	105	0.056
regulation of lymphocyte activation	GO:0051249	240	0.056
platelet activation	GO:0030168	40	0.056
positive regulation of ras gtpase activity	GO:0032320	65	0.056	Mouse
response to fibroblast growth factor	GO:0071774	47	0.056
protein import into nucleus	GO:0006606	95	0.056
kidney rudiment formation	GO:0072003	3	0.055
somatotropin secreting cell differentiation	GO:0060126	4	0.055
skin development	GO:0043588	220	0.055
positive regulation of secretion	GO:0051047	130	0.055
generation of precursor metabolites and energy	GO:0006091	103	0.055
mitotic cell cycle process	GO:1903047	159	0.055
negative regulation of intracellular signal transduction	GO:1902532	167	0.054
regulation of cardiac cell fate specification	GO:2000043	1	0.053
non canonical wnt signaling pathway via mapk cascade	GO:0038030	3	0.053
regulation of membrane potential	GO:0042391	192	0.053
nuclear transport	GO:0051169	139	0.053
positive regulation of actin filament bundle assembly	GO:0032233	11	0.053
organ induction	GO:0001759	21	0.053
brown fat cell differentiation	GO:0050873	36	0.053
regulation of transferase activity	GO:0051338	263	0.053
regulation of peptidyl tyrosine phosphorylation	GO:0050730	93	0.053	Mouse
oxidation reduction process	GO:0055114	342	0.053
testosterone biosynthetic process	GO:0061370	2	0.052
positive regulation of wnt signaling pathway	GO:0030177	45	0.052
renal inner medulla development	GO:0072053	3	0.052
small molecule biosynthetic process	GO:0044283	132	0.052
mesoderm formation	GO:0001707	62	0.052
cellular chemical homeostasis	GO:0055082	215	0.052
cellular response to fibroblast growth factor stimulus	GO:0044344	47	0.052
transforming growth factor beta2 production	GO:0032906	2	0.052
endodermal cell fate specification	GO:0001714	4	0.051
negative regulation of immune system process	GO:0002683	209	0.051
striated muscle tissue development	GO:0014706	293	0.051
positive regulation of cell morphogenesis involved in differentiation	GO:0010770	72	0.051	Mouse
negative regulation of axon extension	GO:0030517	19	0.051	Mouse
metanephric renal vesicle morphogenesis	GO:0072283	12	0.050
negative regulation of growth	GO:0045926	99	0.050	Mouse
cardiac muscle cell differentiation	GO:0055007	69	0.050
sodium ion export from cell	GO:0036376	1	0.050
mitochondrion organization	GO:0007005	134	0.050
sodium ion transport	GO:0006814	73	0.050
neuronal action potential	GO:0019228	54	0.050
positive regulation of peptidyl tyrosine phosphorylation	GO:0050731	61	0.050	Mouse
cellular response to extracellular stimulus	GO:0031668	81	0.049
positive regulation of programmed cell death	GO:0043068	218	0.049
metanephric nephron epithelium development	GO:0072243	19	0.049
establishment of endothelial blood brain barrier	GO:0014045	3	0.049
response to acid chemical	GO:0001101	111	0.049
fat cell differentiation	GO:0045444	160	0.049
carboxylic acid transport	GO:0046942	100	0.049
alcohol metabolic process	GO:0006066	116	0.048
negative regulation of prostatic bud formation	GO:0060686	4	0.048
lung field specification	GO:0060424	3	0.048
inorganic cation transmembrane transport	GO:0098662	207	0.048
regulation of cell cycle phase transition	GO:1901987	77	0.048
positive regulation of epithelial cell proliferation	GO:0050679	68	0.048
negative regulation of epithelial cell proliferation	GO:0050680	64	0.048
negative regulation of nervous system development	GO:0051961	156	0.047	Mouse
tissue migration	GO:0090130	68	0.047	Mouse
myeloid leukocyte differentiation	GO:0002573	119	0.047
regulation of cell cycle process	GO:0010564	160	0.047
ear morphogenesis	GO:0042471	118	0.047
mesonephros development	GO:0001823	97	0.047
positive regulation of secretion by cell	GO:1903532	114	0.047
extracellular structure organization	GO:0043062	148	0.047
positive regulation of hormone secretion	GO:0046887	38	0.046
skeletal system morphogenesis	GO:0048705	203	0.046
labyrinthine layer development	GO:0060711	49	0.046
regulation of protein kinase activity	GO:0045859	232	0.046
regulation of protein tyrosine kinase activity	GO:0061097	17	0.046
regulation of circadian sleep wake cycle	GO:0042749	3	0.046
positive regulation of muscle tissue development	GO:1901863	32	0.046
lipid localization	GO:0010876	126	0.045
regulation of morphogenesis of a branching structure	GO:0060688	53	0.045
regulation of hormone levels	GO:0010817	211	0.045
hematopoietic progenitor cell differentiation	GO:0002244	143	0.045
extracellular matrix cell signaling	GO:0035426	5	0.045

Sema3b disease predictions

Disease predictions are made from cross-annotation of human disease genes to the identified functional analogs in mouse and predicted with the mouse functional network.

Disease	DO term ID	Probability
disease of anatomical entity	DOID:7	0.186
nervous system disease	DOID:863	0.186
sensory system disease	DOID:0050155	0.151
musculoskeletal system disease	DOID:17	0.077
eye and adnexa disease	DOID:1492	0.054
eye disease	DOID:5614	0.054

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