IMP: Integrative Multi-species Prediction

Mus musculus

202 known processes

Lrrk2

leucine-rich repeat kinase 2

(Aliases: cI-46,D630001M17Rik,Gm927,9330188B09Rik,4921513O20Rik,AW561911)

Ensembl: ENSMUSG00000036273
Entrez: 66725
UniProtKB: Q5S006
UniProtKB: Q9CQG8

Process Predictions
Disease Predictions

Lrrk2 biological process predictions

Show only novel predictionsHighlight processes of functional analogs

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Biological process	GO term ID	Process size	Probability	Func Analog Org
purine ribonucleoside triphosphate metabolic process	GO:0009205	220	0.994	Human
nucleotide catabolic process	GO:0009166	217	0.992	Human
purine nucleoside metabolic process	GO:0042278	241	0.991	Human
nucleotide metabolic process	GO:0009117	332	0.984	Human
purine ribonucleotide metabolic process	GO:0009150	290	0.982	Human
positive regulation of protein export from nucleus	GO:0046827	4	0.977
establishment of organelle localization	GO:0051656	122	0.971
organelle localization	GO:0051640	179	0.965
nucleoside triphosphate metabolic process	GO:0009141	230	0.962	Human
nucleoside catabolic process	GO:0009164	206	0.960	Human
ribonucleoside triphosphate catabolic process	GO:0009203	199	0.958	Human
purine nucleoside triphosphate metabolic process	GO:0009144	226	0.957	Human
glycosyl compound metabolic process	GO:1901657	246	0.954	Human
nucleoside triphosphate catabolic process	GO:0009143	205	0.946	Human
ribonucleoside metabolic process	GO:0009119	245	0.938	Human
ribonucleotide catabolic process	GO:0009261	208	0.935	Human
purine nucleoside catabolic process	GO:0006152	205	0.931	Human
purine ribonucleoside metabolic process	GO:0046128	241	0.915	Human
thermosensory behavior	GO:0040040	1	0.914
ribose phosphate metabolic process	GO:0019693	291	0.907	Human
regulation of actin cytoskeleton organization	GO:0032956	84	0.905
ras protein signal transduction	GO:0007265	77	0.904
organic cyclic compound catabolic process	GO:1901361	295	0.903	Human
purine ribonucleotide catabolic process	GO:0009154	208	0.903	Human
purine ribonucleoside catabolic process	GO:0046130	205	0.891	Human
intracellular protein transport	GO:0006886	204	0.890	Human
gtp catabolic process	GO:0006184	143	0.880	Human
nucleoside metabolic process	GO:0009116	246	0.878	Human
keratinocyte development	GO:0003334	10	0.870
oocyte axis specification	GO:0007309	2	0.864
organophosphate catabolic process	GO:0046434	232	0.857	Human
ribonucleotide metabolic process	GO:0009259	291	0.841	Human
glycosyl compound catabolic process	GO:1901658	206	0.840	Human
ribonucleoside triphosphate metabolic process	GO:0009199	220	0.835	Human
heterocycle catabolic process	GO:0046700	280	0.830	Human
mitochondrion distribution	GO:0048311	4	0.830	Human Fly
regulation of cellular component biogenesis	GO:0044087	181	0.819
protein targeting	GO:0006605	143	0.818	Human
purine containing compound metabolic process	GO:0072521	311	0.817	Human
establishment or maintenance of microtubule cytoskeleton polarity	GO:0030951	1	0.802
nucleus localization	GO:0051647	20	0.801
nucleoside phosphate catabolic process	GO:1901292	222	0.798	Human
aromatic compound catabolic process	GO:0019439	286	0.794	Human
regulation of mitochondrial fission	GO:0090140	3	0.785
microtubule cytoskeleton organization	GO:0000226	157	0.785	Fly
spindle localization	GO:0051653	22	0.785
purine nucleotide metabolic process	GO:0006163	302	0.781	Human
purine ribonucleoside triphosphate catabolic process	GO:0009207	199	0.780	Human
carbohydrate derivative catabolic process	GO:1901136	231	0.778	Human
negative regulation of ubiquitin protein transferase activity	GO:0051444	3	0.773
regulation of protein complex assembly	GO:0043254	83	0.772
meiotic cell cycle	GO:0051321	122	0.771
regulation of ubiquitin protein ligase activity involved in mitotic cell cycle	GO:0051439	1	0.764
nucleobase containing small molecule metabolic process	GO:0055086	352	0.758	Human
ribonucleoside catabolic process	GO:0042454	206	0.757	Human
purine containing compound catabolic process	GO:0072523	213	0.752	Human
regulation of exit from mitosis	GO:0007096	1	0.747
guanosine containing compound metabolic process	GO:1901068	144	0.738	Human
membrane organization	GO:0061024	245	0.729
nucleoside phosphate metabolic process	GO:0006753	338	0.727	Human
oocyte construction	GO:0007308	2	0.720
dephosphorylation	GO:0016311	129	0.719
purine nucleoside triphosphate catabolic process	GO:0009146	203	0.705	Human
small gtpase mediated signal transduction	GO:0007264	97	0.702
microtubule based process	GO:0007017	236	0.696	Fly
purine nucleotide catabolic process	GO:0006195	211	0.695	Human
positive regulation of protein transport	GO:0051222	93	0.693
regulation of purine nucleotide catabolic process	GO:0033121	122	0.693	Human
regulation of ras protein signal transduction	GO:0046578	114	0.688
organonitrogen compound catabolic process	GO:1901565	264	0.682	Human
regulation of cytoskeleton organization	GO:0051493	122	0.682	Fly
gtp metabolic process	GO:0046039	144	0.670	Human
actin polymerization or depolymerization	GO:0008154	54	0.669
negative regulation of ligase activity	GO:0051352	3	0.669
cytokinesis	GO:0000910	17	0.659
positive regulation of apoptotic process	GO:0043065	217	0.655
protein polymerization	GO:0051258	57	0.642
regulation of epidermal cell division	GO:0010482	3	0.641
regulation of actin filament based process	GO:0032970	99	0.641
endocytosis	GO:0006897	168	0.628	Human Fly
positive regulation of intracellular transport	GO:0032388	70	0.614
regulation of hydrolase activity	GO:0051336	246	0.603	Human
regulation of ligase activity	GO:0051340	10	0.602
negative regulation of phosphorus metabolic process	GO:0010563	184	0.591
energy derivation by oxidation of organic compounds	GO:0015980	77	0.559
positive regulation of mapk cascade	GO:0043410	170	0.557	Human
regulation of gtp catabolic process	GO:0033124	113	0.549	Human
positive regulation of programmed cell death	GO:0043068	218	0.548	Human
establishment or maintenance of cytoskeleton polarity	GO:0030952	2	0.544
cellular protein complex assembly	GO:0043623	116	0.543
regulation of transferase activity	GO:0051338	263	0.540	Human
lamellipodium organization	GO:0097581	29	0.536
energy reserve metabolic process	GO:0006112	39	0.532
regulation of lamellipodium assembly	GO:0010591	3	0.532
regulation of protein stability	GO:0031647	52	0.530
positive regulation of cell death	GO:0010942	224	0.518	Human
organism emergence from protective structure	GO:0071684	4	0.518
vacuole organization	GO:0007033	38	0.513
regulation of intracellular protein transport	GO:0033157	82	0.512	Human
chromosome segregation	GO:0007059	48	0.510
atp metabolic process	GO:0046034	75	0.500
negative regulation of protein modification process	GO:0031400	163	0.495
cognition	GO:0050890	149	0.491
protein export from nucleus	GO:0006611	20	0.490
synaptic transmission	GO:0007268	329	0.485
forebrain development	GO:0030900	302	0.485	Human
positive regulation of gtpase activity	GO:0043547	85	0.483	Human
actin cytoskeleton organization	GO:0030036	220	0.479
establishment of mitotic spindle localization	GO:0040001	12	0.477
g protein coupled receptor signaling pathway	GO:0007186	243	0.475
establishment of spindle localization	GO:0051293	19	0.471
regulation of kinase activity	GO:0043549	249	0.469	Human
mitochondrion organization	GO:0007005	134	0.462	Human Fly
cell division	GO:0051301	120	0.454
regulation of protein serine threonine kinase activity	GO:0071900	157	0.454	Human
negative regulation of protein metabolic process	GO:0051248	282	0.448
regulation of mapk cascade	GO:0043408	248	0.440	Human
cell adhesion	GO:0007155	329	0.430
regulation of actin filament polymerization	GO:0030833	38	0.417
regulation of protein transport	GO:0051223	163	0.413	Human
regulation of ubiquitin protein transferase activity	GO:0051438	7	0.409
establishment or maintenance of cell polarity	GO:0007163	86	0.404
cellular glucan metabolic process	GO:0006073	32	0.396
regulation of mitochondrion organization	GO:0010821	27	0.393	Human
actin filament organization	GO:0007015	113	0.390
positive regulation of intracellular protein transport	GO:0090316	42	0.390
aggresome assembly	GO:0070842	2	0.388
negative regulation of actin filament depolymerization	GO:0030835	9	0.386
rho protein signal transduction	GO:0007266	32	0.386
regulation of establishment of protein localization	GO:0070201	181	0.377	Human
muscle cell differentiation	GO:0042692	261	0.359
positive regulation of mitochondrion organization	GO:0010822	17	0.355
cellular nitrogen compound catabolic process	GO:0044270	280	0.354	Human
glucan metabolic process	GO:0044042	32	0.350
positive regulation of rac gtpase activity	GO:0032855	14	0.348
positive regulation of organelle organization	GO:0010638	128	0.346
positive regulation of nucleocytoplasmic transport	GO:0046824	30	0.341
regulation of protein export from nucleus	GO:0046825	11	0.338
epidermal cell division	GO:0010481	3	0.321
actin filament polymerization	GO:0030041	44	0.318
developmental maturation	GO:0021700	193	0.317	Human Fly
zygote asymmetric cell division	GO:0010070	2	0.316
organelle fission	GO:0048285	170	0.316
nucleoside monophosphate metabolic process	GO:0009123	85	0.315
regulation of organelle organization	GO:0033043	289	0.314	Human Fly
regulation of intracellular transport	GO:0032386	159	0.305	Human
inclusion body assembly	GO:0070841	3	0.303
mapk cascade	GO:0000165	281	0.298	Human
hatching	GO:0035188	4	0.296
generation of precursor metabolites and energy	GO:0006091	103	0.293
negative regulation of keratinocyte proliferation	GO:0010839	7	0.288
negative regulation of dephosphorylation	GO:0035305	9	0.287
divalent metal ion transport	GO:0070838	172	0.283
regulation of synaptic plasticity	GO:0048167	87	0.282
negative regulation of transferase activity	GO:0051348	85	0.277
epithelial cell development	GO:0002064	159	0.276
negative regulation of molecular function	GO:0044092	258	0.276	Human
telencephalon development	GO:0021537	186	0.275	Human
neuron migration	GO:0001764	122	0.275
negative regulation of protein phosphorylation	GO:0001933	126	0.274
positive regulation of cell development	GO:0010720	237	0.274
muscle cell development	GO:0055001	133	0.271
intracellular distribution of mitochondria	GO:0048312	1	0.268	Human Fly
regulation of cell morphogenesis involved in differentiation	GO:0010769	151	0.266
meiotic nuclear division	GO:0007126	115	0.263
positive regulation of apoptotic signaling pathway	GO:2001235	95	0.258
guanosine containing compound catabolic process	GO:1901069	144	0.255	Human
oxidation reduction process	GO:0055114	342	0.254	Human
regulation of substrate adhesion dependent cell spreading	GO:1900024	12	0.253
polysaccharide metabolic process	GO:0005976	39	0.249
regionalization	GO:0003002	337	0.247
positive regulation of nucleotide catabolic process	GO:0030813	88	0.236	Human
regulation of rho gtpase activity	GO:0032319	58	0.234
establishment of spindle orientation	GO:0051294	15	0.234
regulation of cell adhesion	GO:0030155	154	0.230
regulation of nucleoside metabolic process	GO:0009118	130	0.229	Human
membrane fusion	GO:0061025	38	0.229
regulation of nucleotide catabolic process	GO:0030811	122	0.229	Human
protein localization to organelle	GO:0033365	185	0.228	Human
cellular polysaccharide metabolic process	GO:0044264	38	0.222
mitotic cell cycle process	GO:1903047	159	0.220
protein depolymerization	GO:0051261	34	0.220
positive regulation of ras gtpase activity	GO:0032320	65	0.220
regulation of actin filament length	GO:0030832	45	0.218
regulation of protein ubiquitination	GO:0031396	52	0.215	Human
pole plasm assembly	GO:0007315	2	0.213
purine ribonucleoside monophosphate metabolic process	GO:0009167	80	0.211
regulation of protein kinase activity	GO:0045859	232	0.209	Human
regulation of cell division	GO:0051302	76	0.207
positive regulation of cytoplasmic transport	GO:1903651	40	0.207
mitotic nuclear division	GO:0007067	48	0.206
mitotic cytokinesis	GO:0000281	4	0.206
regulation of cell substrate adhesion	GO:0010810	73	0.198
positive regulation of cell substrate adhesion	GO:0010811	47	0.195
positive regulation of cellular amino acid metabolic process	GO:0045764	3	0.192
ribonucleoside monophosphate catabolic process	GO:0009158	57	0.191
glycogen metabolic process	GO:0005977	32	0.190
nuclear transport	GO:0051169	139	0.189
ribonucleoside monophosphate metabolic process	GO:0009161	80	0.186
cytoplasmic transport	GO:0016482	234	0.184	Human
regulation of cell projection assembly	GO:0060491	38	0.183
single fertilization	GO:0007338	82	0.181
microtubule based movement	GO:0007018	84	0.181
purine nucleoside monophosphate metabolic process	GO:0009126	81	0.180
regulation of ras gtpase activity	GO:0032318	88	0.180
cellular amino acid metabolic process	GO:0006520	103	0.180
actin filament depolymerization	GO:0030042	15	0.179
regulation of cellular amine metabolic process	GO:0033238	20	0.177
positive regulation of lamellipodium organization	GO:1902745	3	0.175
regulation of cell projection organization	GO:0031344	206	0.174
regulation of cyclin dependent protein serine threonine kinase activity	GO:0000079	16	0.170
carbohydrate metabolic process	GO:0005975	230	0.169
cell substrate adhesion	GO:0031589	130	0.168
positive regulation of release of cytochrome c from mitochondria	GO:0090200	5	0.166
positive regulation of mitochondrial fission	GO:0090141	2	0.165
apoptotic mitochondrial changes	GO:0008637	48	0.163
chromosome movement towards spindle pole	GO:0051305	3	0.162
regulation of actin polymerization or depolymerization	GO:0008064	45	0.161
positive regulation of rho gtpase activity	GO:0032321	41	0.160
keratinization	GO:0031424	9	0.160
regulation of synaptic growth at neuromuscular junction	GO:0008582	4	0.159
negative regulation of protein dephosphorylation	GO:0035308	2	0.158
regulation of cellular catabolic process	GO:0031329	242	0.156
regulation of peptidyl serine phosphorylation	GO:0033135	39	0.155
regulation of protein complex disassembly	GO:0043244	28	0.155
cell fate specification	GO:0001708	72	0.154
keratinocyte differentiation	GO:0030216	48	0.154
oogenesis	GO:0048477	56	0.154
physiological muscle hypertrophy	GO:0003298	3	0.153
cellular carbohydrate metabolic process	GO:0044262	119	0.152
regulation of secretion	GO:0051046	274	0.150	Human
syncytium formation by plasma membrane fusion	GO:0000768	42	0.149
positive regulation of secretion by cell	GO:1903532	114	0.148
atp catabolic process	GO:0006200	55	0.148
hippocampus development	GO:0021766	52	0.147
positive regulation of growth	GO:0045927	104	0.146
regulation of body fluid levels	GO:0050878	162	0.145
regulation of cell growth	GO:0001558	91	0.145
cell growth	GO:0016049	130	0.143	Worm
vesicle organization	GO:0016050	60	0.143
learning or memory	GO:0007611	148	0.143
negative regulation of organelle organization	GO:0010639	90	0.141	Human
positive regulation of gtp catabolic process	GO:0033126	85	0.137	Human
necroptotic process	GO:0070266	21	0.137
positive regulation of erk1 and erk2 cascade	GO:0070374	47	0.137
nucleoside monophosphate catabolic process	GO:0009125	59	0.133
cellular ketone metabolic process	GO:0042180	84	0.132
synaptic vesicle localization	GO:0097479	59	0.132
negative regulation of cell growth involved in cardiac muscle cell development	GO:0061052	2	0.132
membrane invagination	GO:0010324	17	0.131
cellular calcium ion homeostasis	GO:0006874	119	0.131
regulation of cellular amino acid metabolic process	GO:0006521	5	0.131
positive regulation of hydrolase activity	GO:0051345	148	0.131	Human
erk1 and erk2 cascade	GO:0070371	77	0.131
regulation of protein localization	GO:0032880	231	0.130	Human
oocyte anterior posterior axis specification	GO:0007314	2	0.130
regulation of rho protein signal transduction	GO:0035023	71	0.130
regulation of cell growth involved in cardiac muscle cell development	GO:0061050	3	0.129
filopodium assembly	GO:0046847	19	0.128
negative regulation of cellular protein metabolic process	GO:0032269	247	0.126
substantia nigra development	GO:0021762	2	0.126
protein targeting to vacuole	GO:0006623	3	0.126
inositol phosphate mediated signaling	GO:0048016	13	0.125
multicellular organismal water homeostasis	GO:0050891	23	0.125
meiotic cell cycle process	GO:1903046	77	0.124
protein secretion	GO:0009306	111	0.124
regulation of anatomical structure size	GO:0090066	178	0.123
regulation of intrinsic apoptotic signaling pathway	GO:2001242	61	0.123
engulfment of apoptotic cell	GO:0043652	3	0.123
protein stabilization	GO:0050821	25	0.122
positive regulation of ras protein signal transduction	GO:0046579	13	0.122
mitotic spindle checkpoint	GO:0071174	9	0.122
regulation of secretion by cell	GO:1903530	249	0.121	Human
limbic system development	GO:0021761	72	0.121
regulation of mitotic cell cycle phase transition	GO:1901990	73	0.121
phagocytosis	GO:0006909	66	0.119
physiological cardiac muscle hypertrophy	GO:0003301	3	0.119
positive regulation of cell morphogenesis involved in differentiation	GO:0010770	72	0.119
positive regulation of mitochondrial outer membrane permeabilization involved in apoptotic signaling pathway	GO:1901030	6	0.118
establishment of protein localization to organelle	GO:0072594	118	0.118	Human
regulation of cellular component size	GO:0032535	121	0.117
transmembrane receptor protein tyrosine kinase signaling pathway	GO:0007169	247	0.116
olfactory learning	GO:0008355	2	0.115
regulation of neuron projection development	GO:0010975	169	0.113
cellular response to dna damage stimulus	GO:0006974	207	0.111
regulation of dephosphorylation	GO:0035303	18	0.110
establishment of synaptic vesicle localization	GO:0097480	57	0.109
macromolecular complex disassembly	GO:0032984	43	0.108
post embryonic hemopoiesis	GO:0035166	4	0.107
regulation of protein binding	GO:0043393	60	0.106	Human
negative regulation of protein modification by small protein conjugation or removal	GO:1903321	20	0.106
female gamete generation	GO:0007292	74	0.105
regulation of protein depolymerization	GO:1901879	26	0.105
purine ribonucleoside monophosphate catabolic process	GO:0009169	57	0.105
regulation of microtubule cytoskeleton organization	GO:0070507	37	0.104	Fly
muscle contraction	GO:0006936	101	0.104
mitochondrion localization	GO:0051646	9	0.103	Human Fly
mitotic cell cycle embryonic	GO:0045448	5	0.103
regulation of release of cytochrome c from mitochondria	GO:0090199	11	0.103
fertilization	GO:0009566	127	0.103
negative regulation of cellular component organization	GO:0051129	194	0.101	Human
epithelial cell proliferation	GO:0050673	174	0.100
cardiac muscle tissue development	GO:0048738	130	0.099
regulation of neuronal synaptic plasticity	GO:0048168	30	0.099
regulation of jnk cascade	GO:0046328	62	0.098
regulation of cytoplasmic transport	GO:1903649	112	0.098	Human
maintenance of location	GO:0051235	89	0.098
negative regulation of cellular amino acid metabolic process	GO:0045763	0	0.097
oocyte development	GO:0048599	33	0.097
regulation of nucleocytoplasmic transport	GO:0046822	73	0.097
nuclear dna replication	GO:0033260	3	0.096
dna replication	GO:0006260	52	0.096
purine nucleoside monophosphate catabolic process	GO:0009128	58	0.095
heart morphogenesis	GO:0003007	178	0.095
myeloid leukocyte activation	GO:0002274	83	0.094
amine metabolic process	GO:0009308	45	0.094
striated muscle contraction	GO:0006941	45	0.094
cerebral cortex development	GO:0021987	86	0.094
regulation of keratinocyte proliferation	GO:0010837	15	0.094
apoptotic signaling pathway	GO:0097190	306	0.093
nuclear division	GO:0000280	158	0.093
actomyosin structure organization	GO:0031032	56	0.093
regulation of cell migration	GO:0030334	219	0.092
muscle tissue development	GO:0060537	308	0.091
establishment of skin barrier	GO:0061436	14	0.091
positive regulation of transferase activity	GO:0051347	167	0.091	Human
cell growth involved in cardiac muscle cell development	GO:0061049	3	0.089
divalent inorganic cation homeostasis	GO:0072507	138	0.088
regulation of epidermal cell differentiation	GO:0045604	21	0.088
positive regulation of secretion	GO:0051047	130	0.086
oocyte differentiation	GO:0009994	35	0.086
negative regulation of protein depolymerization	GO:1901880	21	0.086
keratinocyte proliferation	GO:0043616	21	0.085
positive regulation of stress activated mapk cascade	GO:0032874	48	0.085
positive regulation of cellular catabolic process	GO:0031331	148	0.085
positive regulation of nucleotide metabolic process	GO:0045981	114	0.085	Human
second messenger mediated signaling	GO:0019932	73	0.085
protein modification by small protein conjugation or removal	GO:0070647	207	0.085	Human
jnk cascade	GO:0007254	72	0.084
monocarboxylic acid metabolic process	GO:0032787	191	0.084
stress activated mapk cascade	GO:0051403	80	0.083
extracellular matrix organization	GO:0030198	147	0.082
asymmetric stem cell division	GO:0098722	3	0.082
regulation of mitosis	GO:0007088	29	0.082
negative regulation of mitosis	GO:0045839	10	0.081
positive regulation of purine nucleotide metabolic process	GO:1900544	114	0.081	Human
positive regulation of cell adhesion	GO:0045785	80	0.081
germ cell development	GO:0007281	185	0.080
endomembrane system organization	GO:0010256	147	0.079
regulation of stress activated mapk cascade	GO:0032872	69	0.079
dna metabolic process	GO:0006259	303	0.079
regulation of actin filament depolymerization	GO:0030834	13	0.079
water homeostasis	GO:0030104	27	0.078
cation transport	GO:0006812	399	0.076
negative regulation of dendrite development	GO:2000171	9	0.076
pallium development	GO:0021543	120	0.076
regulation of epidermis development	GO:0045682	33	0.075
positive regulation of cell growth	GO:0030307	33	0.075
regulation of water loss via skin	GO:0033561	16	0.074
syncytium formation	GO:0006949	43	0.074
cell cycle checkpoint	GO:0000075	47	0.074
multicellular organismal reproductive behavior	GO:0033057	23	0.074
organic anion transport	GO:0015711	137	0.072
negative regulation of cytoskeleton organization	GO:0051494	36	0.072
regulation of membrane potential	GO:0042391	192	0.072
regulation of purine nucleotide metabolic process	GO:1900542	169	0.071	Human
regulation of erk1 and erk2 cascade	GO:0070372	71	0.071
protein oligomerization	GO:0051259	67	0.071
receptor mediated endocytosis	GO:0006898	51	0.070
positive regulation of cellular component biogenesis	GO:0044089	94	0.069
central nervous system neuron differentiation	GO:0021953	162	0.069
cell junction assembly	GO:0034329	52	0.069
positive regulation of epidermal cell differentiation	GO:0045606	6	0.069
divalent inorganic cation transport	GO:0072511	178	0.068
negative regulation of nuclear division	GO:0051784	19	0.068
negative regulation of epithelial cell proliferation	GO:0050680	64	0.067
regulation of epithelial cell proliferation	GO:0050678	141	0.067
response to organonitrogen compound	GO:0010243	246	0.067	Human
posttranscriptional regulation of gene expression	GO:0010608	155	0.067
protein localization to mitochondrion	GO:0070585	15	0.066	Human
epidermis development	GO:0008544	187	0.066
response to temperature stimulus	GO:0009266	55	0.066
negative regulation of phosphate metabolic process	GO:0045936	184	0.066
protein folding	GO:0006457	28	0.066
exit from mitosis	GO:0010458	3	0.065
organic acid transport	GO:0015849	101	0.065
extrinsic apoptotic signaling pathway	GO:0097191	126	0.065
regulation of defense response	GO:0031347	233	0.064
neutrophil mediated immunity	GO:0002446	19	0.064
regulation of proteasomal ubiquitin dependent protein catabolic process	GO:0032434	40	0.063
cell fate commitment	GO:0045165	210	0.063
intrinsic apoptotic signaling pathway	GO:0097193	132	0.062
muscle system process	GO:0003012	141	0.062
positive regulation of cellular amine metabolic process	GO:0033240	5	0.062
positive regulation of fibroblast migration	GO:0010763	5	0.062
regulation of microtubule based process	GO:0032886	52	0.062	Fly
nuclear migration	GO:0007097	6	0.061
neural tube formation	GO:0001841	108	0.061
positive regulation of nucleoside metabolic process	GO:0045979	91	0.060	Human
cell maturation	GO:0048469	127	0.060	Human
chemotaxis	GO:0006935	247	0.060	Worm
fatty acid metabolic process	GO:0006631	121	0.060
nuclear export	GO:0051168	34	0.059
anatomical structure homeostasis	GO:0060249	145	0.059	Mouse
protein catabolic process	GO:0030163	221	0.059
negative regulation of protein ubiquitination	GO:0031397	19	0.059
establishment of mitochondrion localization	GO:0051654	4	0.058
synapse organization	GO:0050808	125	0.058	Human Fly
cellular metal ion homeostasis	GO:0006875	151	0.058
circulatory system process	GO:0003013	197	0.058
dna integrity checkpoint	GO:0031570	28	0.058
cellular protein complex disassembly	GO:0043624	36	0.058
exocyst localization	GO:0051601	2	0.057
intracellular mrna localization	GO:0008298	4	0.056
regulation of cell cycle	GO:0051726	281	0.056
positive regulation of jnk cascade	GO:0046330	46	0.056
sensory perception	GO:0007600	245	0.055
response to organic cyclic compound	GO:0014070	198	0.055	Human
adherens junction assembly	GO:0034333	22	0.055
dna damage checkpoint	GO:0000077	26	0.055
positive regulation of substrate adhesion dependent cell spreading	GO:1900026	8	0.055
positive regulation of synaptic growth at neuromuscular junction	GO:0045887	1	0.055
exocytosis	GO:0006887	121	0.054	Human
stress activated protein kinase signaling cascade	GO:0031098	81	0.054
regulated secretory pathway	GO:0045055	32	0.054
protein localization to plasma membrane	GO:0072659	57	0.054
regulation of protein modification by small protein conjugation or removal	GO:1903320	57	0.054	Human
regulation of mitotic cell cycle	GO:0007346	126	0.054
positive regulation of protein modification process	GO:0031401	299	0.054	Human Mouse
mitotic cell cycle	GO:0000278	195	0.054
wnt signaling pathway	GO:0016055	188	0.053
protein modification by small protein conjugation	GO:0032446	187	0.053	Human
multi multicellular organism process	GO:0044706	109	0.053
regulation of adrenergic receptor signaling pathway	GO:0071877	4	0.053
fibroblast migration	GO:0010761	21	0.052
cellular ion homeostasis	GO:0006873	165	0.052
defense response to bacterium	GO:0042742	119	0.052
genetic imprinting	GO:0071514	27	0.052
organic hydroxy compound metabolic process	GO:1901615	203	0.052
regulation of heart contraction	GO:0008016	77	0.052
sulfur compound biosynthetic process	GO:0044272	37	0.052
regulation of nuclear division	GO:0051783	56	0.052
canonical wnt signaling pathway involved in heart development	GO:0061316	3	0.051
cellular lipid metabolic process	GO:0044255	323	0.051
establishment of mitotic spindle orientation	GO:0000132	12	0.051
adult behavior	GO:0030534	135	0.051
platelet derived growth factor receptor signaling pathway	GO:0048008	32	0.051
carboxylic acid transport	GO:0046942	100	0.051
reactive oxygen species metabolic process	GO:0072593	84	0.050	Human
muscle adaptation	GO:0043500	39	0.050
plasma membrane organization	GO:0007009	90	0.050
multi organism reproductive behavior	GO:0044705	29	0.049
negative regulation of protein complex assembly	GO:0031333	25	0.049
regulation of map kinase activity	GO:0043405	120	0.049	Human
regulation of cellular ketone metabolic process	GO:0010565	66	0.049
positive regulation of lamellipodium assembly	GO:0010592	2	0.049
asymmetric cell division	GO:0008356	8	0.048
axonogenesis	GO:0007409	274	0.048	Worm
positive regulation of cytoskeleton organization	GO:0051495	49	0.048
calcineurin nfat signaling cascade	GO:0033173	8	0.048
cell fate determination	GO:0001709	32	0.048
regulation of lamellipodium organization	GO:1902743	5	0.048
small molecule biosynthetic process	GO:0044283	132	0.047
signal transduction in absence of ligand	GO:0038034	55	0.047
dendrite development	GO:0016358	115	0.047
extrinsic apoptotic signaling pathway in absence of ligand	GO:0097192	55	0.047
negative regulation of cell proliferation	GO:0008285	296	0.047
necrotic cell death	GO:0070265	30	0.047
blood circulation	GO:0008015	195	0.047
actin filament based movement	GO:0030048	23	0.047
arp2 3 complex mediated actin nucleation	GO:0034314	3	0.046
positive regulation of protein phosphorylation	GO:0001934	242	0.046	Human Mouse
regulation of proteolysis involved in cellular protein catabolic process	GO:1903050	56	0.046
positive regulation of peptidyl serine phosphorylation	GO:0033138	25	0.046
myeloid leukocyte mediated immunity	GO:0002444	42	0.046
proteasome mediated ubiquitin dependent protein catabolic process	GO:0043161	88	0.045
negative regulation of cellular amine metabolic process	GO:0033239	1	0.045
positive regulation of protein serine threonine kinase activity	GO:0071902	106	0.045	Human
protein complex disassembly	GO:0043241	40	0.045
cardiac muscle contraction	GO:0060048	32	0.045
cellular response to peptide	GO:1901653	92	0.045
regulation of nucleotide metabolic process	GO:0006140	169	0.045	Human
regulation of microtubule polymerization or depolymerization	GO:0031110	20	0.044
regulation of cell cycle process	GO:0010564	160	0.044
nucleocytoplasmic transport	GO:0006913	139	0.044
embryonic epithelial tube formation	GO:0001838	130	0.044
regulation of cell motility	GO:2000145	236	0.044
innate immune response	GO:0045087	157	0.044
multi organism behavior	GO:0051705	62	0.044
regulation of binding	GO:0051098	111	0.044	Human
synapse assembly	GO:0007416	56	0.043
neural nucleus development	GO:0048857	22	0.043
regulation of protein dephosphorylation	GO:0035304	4	0.043
positive regulation of actin filament polymerization	GO:0030838	26	0.043
negative regulation of nfat protein import into nucleus	GO:0051534	3	0.043

Lrrk2 disease predictions

Disease predictions are made from cross-annotation of human disease genes to the identified functional analogs in mouse and predicted with the mouse functional network.

Disease	DO term ID	Probability	Func Analog Org
disease of anatomical entity	DOID:7	0.221	Human
nervous system disease	DOID:863	0.221	Human
central nervous system disease	DOID:331	0.180	Human
sensory system disease	DOID:0050155	0.056

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