Mus musculus

202 known processes

Lrrk2

leucine-rich repeat kinase 2

(Aliases: cI-46,D630001M17Rik,Gm927,9330188B09Rik,4921513O20Rik,AW561911)

Lrrk2 biological process predictions


Filter by process size:
Biological processGO term IDProcess sizeProbabilityFunc Analog Org
purine ribonucleoside triphosphate metabolic processGO:00092052200.994
Human
nucleotide catabolic processGO:00091662170.992
Human
purine nucleoside metabolic processGO:00422782410.991
Human
nucleotide metabolic processGO:00091173320.984
Human
purine ribonucleotide metabolic processGO:00091502900.982
Human
positive regulation of protein export from nucleusGO:004682740.977
establishment of organelle localizationGO:00516561220.971
organelle localizationGO:00516401790.965
nucleoside triphosphate metabolic processGO:00091412300.962
Human
nucleoside catabolic processGO:00091642060.960
Human
ribonucleoside triphosphate catabolic processGO:00092031990.958
Human
purine nucleoside triphosphate metabolic processGO:00091442260.957
Human
glycosyl compound metabolic processGO:19016572460.954
Human
nucleoside triphosphate catabolic processGO:00091432050.946
Human
ribonucleoside metabolic processGO:00091192450.938
Human
ribonucleotide catabolic processGO:00092612080.935
Human
purine nucleoside catabolic processGO:00061522050.931
Human
purine ribonucleoside metabolic processGO:00461282410.915
Human
thermosensory behaviorGO:004004010.914
ribose phosphate metabolic processGO:00196932910.907
Human
regulation of actin cytoskeleton organizationGO:0032956840.905
ras protein signal transductionGO:0007265770.904
organic cyclic compound catabolic processGO:19013612950.903
Human
purine ribonucleotide catabolic processGO:00091542080.903
Human
purine ribonucleoside catabolic processGO:00461302050.891
Human
intracellular protein transportGO:00068862040.890
Human
gtp catabolic processGO:00061841430.880
Human
nucleoside metabolic processGO:00091162460.878
Human
keratinocyte developmentGO:0003334100.870
oocyte axis specificationGO:000730920.864
organophosphate catabolic processGO:00464342320.857
Human
ribonucleotide metabolic processGO:00092592910.841
Human
glycosyl compound catabolic processGO:19016582060.840
Human
ribonucleoside triphosphate metabolic processGO:00091992200.835
Human
heterocycle catabolic processGO:00467002800.830
Human
mitochondrion distributionGO:004831140.830
Human Fly
regulation of cellular component biogenesisGO:00440871810.819
protein targetingGO:00066051430.818
Human
purine containing compound metabolic processGO:00725213110.817
Human
establishment or maintenance of microtubule cytoskeleton polarityGO:003095110.802
nucleus localizationGO:0051647200.801
nucleoside phosphate catabolic processGO:19012922220.798
Human
aromatic compound catabolic processGO:00194392860.794
Human
regulation of mitochondrial fissionGO:009014030.785
microtubule cytoskeleton organizationGO:00002261570.785
Fly
spindle localizationGO:0051653220.785
purine nucleotide metabolic processGO:00061633020.781
Human
purine ribonucleoside triphosphate catabolic processGO:00092071990.780
Human
carbohydrate derivative catabolic processGO:19011362310.778
Human
negative regulation of ubiquitin protein transferase activityGO:005144430.773
regulation of protein complex assemblyGO:0043254830.772
meiotic cell cycleGO:00513211220.771
regulation of ubiquitin protein ligase activity involved in mitotic cell cycleGO:005143910.764
nucleobase containing small molecule metabolic processGO:00550863520.758
Human
ribonucleoside catabolic processGO:00424542060.757
Human
purine containing compound catabolic processGO:00725232130.752
Human
regulation of exit from mitosisGO:000709610.747
guanosine containing compound metabolic processGO:19010681440.738
Human
membrane organizationGO:00610242450.729
nucleoside phosphate metabolic processGO:00067533380.727
Human
oocyte constructionGO:000730820.720
dephosphorylationGO:00163111290.719
purine nucleoside triphosphate catabolic processGO:00091462030.705
Human
small gtpase mediated signal transductionGO:0007264970.702
microtubule based processGO:00070172360.696
Fly
purine nucleotide catabolic processGO:00061952110.695
Human
positive regulation of protein transportGO:0051222930.693
regulation of purine nucleotide catabolic processGO:00331211220.693
Human
regulation of ras protein signal transductionGO:00465781140.688
organonitrogen compound catabolic processGO:19015652640.682
Human
regulation of cytoskeleton organizationGO:00514931220.682
Fly
gtp metabolic processGO:00460391440.670
Human
actin polymerization or depolymerizationGO:0008154540.669
negative regulation of ligase activityGO:005135230.669
cytokinesisGO:0000910170.659
positive regulation of apoptotic processGO:00430652170.655
protein polymerizationGO:0051258570.642
regulation of epidermal cell divisionGO:001048230.641
regulation of actin filament based processGO:0032970990.641
endocytosisGO:00068971680.628
Human Fly
positive regulation of intracellular transportGO:0032388700.614
regulation of hydrolase activityGO:00513362460.603
Human
regulation of ligase activityGO:0051340100.602
negative regulation of phosphorus metabolic processGO:00105631840.591
energy derivation by oxidation of organic compoundsGO:0015980770.559
positive regulation of mapk cascadeGO:00434101700.557
Human
regulation of gtp catabolic processGO:00331241130.549
Human
positive regulation of programmed cell deathGO:00430682180.548
Human
establishment or maintenance of cytoskeleton polarityGO:003095220.544
cellular protein complex assemblyGO:00436231160.543
regulation of transferase activityGO:00513382630.540
Human
lamellipodium organizationGO:0097581290.536
energy reserve metabolic processGO:0006112390.532
regulation of lamellipodium assemblyGO:001059130.532
regulation of protein stabilityGO:0031647520.530
positive regulation of cell deathGO:00109422240.518
Human
organism emergence from protective structureGO:007168440.518
vacuole organizationGO:0007033380.513
regulation of intracellular protein transportGO:0033157820.512
Human
chromosome segregationGO:0007059480.510
atp metabolic processGO:0046034750.500
negative regulation of protein modification processGO:00314001630.495
cognitionGO:00508901490.491
protein export from nucleusGO:0006611200.490
synaptic transmissionGO:00072683290.485
forebrain developmentGO:00309003020.485
Human
positive regulation of gtpase activityGO:0043547850.483
Human
actin cytoskeleton organizationGO:00300362200.479
establishment of mitotic spindle localizationGO:0040001120.477
g protein coupled receptor signaling pathwayGO:00071862430.475
establishment of spindle localizationGO:0051293190.471
regulation of kinase activityGO:00435492490.469
Human
mitochondrion organizationGO:00070051340.462
Human Fly
cell divisionGO:00513011200.454
regulation of protein serine threonine kinase activityGO:00719001570.454
Human
negative regulation of protein metabolic processGO:00512482820.448
regulation of mapk cascadeGO:00434082480.440
Human
cell adhesionGO:00071553290.430
regulation of actin filament polymerizationGO:0030833380.417
regulation of protein transportGO:00512231630.413
Human
regulation of ubiquitin protein transferase activityGO:005143870.409
establishment or maintenance of cell polarityGO:0007163860.404
cellular glucan metabolic processGO:0006073320.396
regulation of mitochondrion organizationGO:0010821270.393
Human
actin filament organizationGO:00070151130.390
positive regulation of intracellular protein transportGO:0090316420.390
aggresome assemblyGO:007084220.388
negative regulation of actin filament depolymerizationGO:003083590.386
rho protein signal transductionGO:0007266320.386
regulation of establishment of protein localizationGO:00702011810.377
Human
muscle cell differentiationGO:00426922610.359
positive regulation of mitochondrion organizationGO:0010822170.355
cellular nitrogen compound catabolic processGO:00442702800.354
Human
glucan metabolic processGO:0044042320.350
positive regulation of rac gtpase activityGO:0032855140.348
positive regulation of organelle organizationGO:00106381280.346
positive regulation of nucleocytoplasmic transportGO:0046824300.341
regulation of protein export from nucleusGO:0046825110.338
epidermal cell divisionGO:001048130.321
actin filament polymerizationGO:0030041440.318
developmental maturationGO:00217001930.317
Human Fly
zygote asymmetric cell divisionGO:001007020.316
organelle fissionGO:00482851700.316
nucleoside monophosphate metabolic processGO:0009123850.315
regulation of organelle organizationGO:00330432890.314
Human Fly
regulation of intracellular transportGO:00323861590.305
Human
inclusion body assemblyGO:007084130.303
mapk cascadeGO:00001652810.298
Human
hatchingGO:003518840.296
generation of precursor metabolites and energyGO:00060911030.293
negative regulation of keratinocyte proliferationGO:001083970.288
negative regulation of dephosphorylationGO:003530590.287
divalent metal ion transportGO:00708381720.283
regulation of synaptic plasticityGO:0048167870.282
negative regulation of transferase activityGO:0051348850.277
epithelial cell developmentGO:00020641590.276
negative regulation of molecular functionGO:00440922580.276
Human
telencephalon developmentGO:00215371860.275
Human
neuron migrationGO:00017641220.275
negative regulation of protein phosphorylationGO:00019331260.274
positive regulation of cell developmentGO:00107202370.274
muscle cell developmentGO:00550011330.271
intracellular distribution of mitochondriaGO:004831210.268
Human Fly
regulation of cell morphogenesis involved in differentiationGO:00107691510.266
meiotic nuclear divisionGO:00071261150.263
positive regulation of apoptotic signaling pathwayGO:2001235950.258
guanosine containing compound catabolic processGO:19010691440.255
Human
oxidation reduction processGO:00551143420.254
Human
regulation of substrate adhesion dependent cell spreadingGO:1900024120.253
polysaccharide metabolic processGO:0005976390.249
regionalizationGO:00030023370.247
positive regulation of nucleotide catabolic processGO:0030813880.236
Human
regulation of rho gtpase activityGO:0032319580.234
establishment of spindle orientationGO:0051294150.234
regulation of cell adhesionGO:00301551540.230
regulation of nucleoside metabolic processGO:00091181300.229
Human
membrane fusionGO:0061025380.229
regulation of nucleotide catabolic processGO:00308111220.229
Human
protein localization to organelleGO:00333651850.228
Human
cellular polysaccharide metabolic processGO:0044264380.222
mitotic cell cycle processGO:19030471590.220
protein depolymerizationGO:0051261340.220
positive regulation of ras gtpase activityGO:0032320650.220
regulation of actin filament lengthGO:0030832450.218
regulation of protein ubiquitinationGO:0031396520.215
Human
pole plasm assemblyGO:000731520.213
purine ribonucleoside monophosphate metabolic processGO:0009167800.211
regulation of protein kinase activityGO:00458592320.209
Human
regulation of cell divisionGO:0051302760.207
positive regulation of cytoplasmic transportGO:1903651400.207
mitotic nuclear divisionGO:0007067480.206
mitotic cytokinesisGO:000028140.206
regulation of cell substrate adhesionGO:0010810730.198
positive regulation of cell substrate adhesionGO:0010811470.195
positive regulation of cellular amino acid metabolic processGO:004576430.192
ribonucleoside monophosphate catabolic processGO:0009158570.191
glycogen metabolic processGO:0005977320.190
nuclear transportGO:00511691390.189
ribonucleoside monophosphate metabolic processGO:0009161800.186
cytoplasmic transportGO:00164822340.184
Human
regulation of cell projection assemblyGO:0060491380.183
single fertilizationGO:0007338820.181
microtubule based movementGO:0007018840.181
purine nucleoside monophosphate metabolic processGO:0009126810.180
regulation of ras gtpase activityGO:0032318880.180
cellular amino acid metabolic processGO:00065201030.180
actin filament depolymerizationGO:0030042150.179
regulation of cellular amine metabolic processGO:0033238200.177
positive regulation of lamellipodium organizationGO:190274530.175
regulation of cell projection organizationGO:00313442060.174
regulation of cyclin dependent protein serine threonine kinase activityGO:0000079160.170
carbohydrate metabolic processGO:00059752300.169
cell substrate adhesionGO:00315891300.168
positive regulation of release of cytochrome c from mitochondriaGO:009020050.166
positive regulation of mitochondrial fissionGO:009014120.165
apoptotic mitochondrial changesGO:0008637480.163
chromosome movement towards spindle poleGO:005130530.162
regulation of actin polymerization or depolymerizationGO:0008064450.161
positive regulation of rho gtpase activityGO:0032321410.160
keratinizationGO:003142490.160
regulation of synaptic growth at neuromuscular junctionGO:000858240.159
negative regulation of protein dephosphorylationGO:003530820.158
regulation of cellular catabolic processGO:00313292420.156
regulation of peptidyl serine phosphorylationGO:0033135390.155
regulation of protein complex disassemblyGO:0043244280.155
cell fate specificationGO:0001708720.154
keratinocyte differentiationGO:0030216480.154
oogenesisGO:0048477560.154
physiological muscle hypertrophyGO:000329830.153
cellular carbohydrate metabolic processGO:00442621190.152
regulation of secretionGO:00510462740.150
Human
syncytium formation by plasma membrane fusionGO:0000768420.149
positive regulation of secretion by cellGO:19035321140.148
atp catabolic processGO:0006200550.148
hippocampus developmentGO:0021766520.147
positive regulation of growthGO:00459271040.146
regulation of body fluid levelsGO:00508781620.145
regulation of cell growthGO:0001558910.145
cell growthGO:00160491300.143
Worm
vesicle organizationGO:0016050600.143
learning or memoryGO:00076111480.143
negative regulation of organelle organizationGO:0010639900.141
Human
positive regulation of gtp catabolic processGO:0033126850.137
Human
necroptotic processGO:0070266210.137
positive regulation of erk1 and erk2 cascadeGO:0070374470.137
nucleoside monophosphate catabolic processGO:0009125590.133
cellular ketone metabolic processGO:0042180840.132
synaptic vesicle localizationGO:0097479590.132
negative regulation of cell growth involved in cardiac muscle cell developmentGO:006105220.132
membrane invaginationGO:0010324170.131
cellular calcium ion homeostasisGO:00068741190.131
regulation of cellular amino acid metabolic processGO:000652150.131
positive regulation of hydrolase activityGO:00513451480.131
Human
erk1 and erk2 cascadeGO:0070371770.131
regulation of protein localizationGO:00328802310.130
Human
oocyte anterior posterior axis specificationGO:000731420.130
regulation of rho protein signal transductionGO:0035023710.130
regulation of cell growth involved in cardiac muscle cell developmentGO:006105030.129
filopodium assemblyGO:0046847190.128
negative regulation of cellular protein metabolic processGO:00322692470.126
substantia nigra developmentGO:002176220.126
protein targeting to vacuoleGO:000662330.126
inositol phosphate mediated signalingGO:0048016130.125
multicellular organismal water homeostasisGO:0050891230.125
meiotic cell cycle processGO:1903046770.124
protein secretionGO:00093061110.124
regulation of anatomical structure sizeGO:00900661780.123
regulation of intrinsic apoptotic signaling pathwayGO:2001242610.123
engulfment of apoptotic cellGO:004365230.123
protein stabilizationGO:0050821250.122
positive regulation of ras protein signal transductionGO:0046579130.122
mitotic spindle checkpointGO:007117490.122
regulation of secretion by cellGO:19035302490.121
Human
limbic system developmentGO:0021761720.121
regulation of mitotic cell cycle phase transitionGO:1901990730.121
phagocytosisGO:0006909660.119
physiological cardiac muscle hypertrophyGO:000330130.119
positive regulation of cell morphogenesis involved in differentiationGO:0010770720.119
positive regulation of mitochondrial outer membrane permeabilization involved in apoptotic signaling pathwayGO:190103060.118
establishment of protein localization to organelleGO:00725941180.118
Human
regulation of cellular component sizeGO:00325351210.117
transmembrane receptor protein tyrosine kinase signaling pathwayGO:00071692470.116
olfactory learningGO:000835520.115
regulation of neuron projection developmentGO:00109751690.113
cellular response to dna damage stimulusGO:00069742070.111
regulation of dephosphorylationGO:0035303180.110
establishment of synaptic vesicle localizationGO:0097480570.109
macromolecular complex disassemblyGO:0032984430.108
post embryonic hemopoiesisGO:003516640.107
regulation of protein bindingGO:0043393600.106
Human
negative regulation of protein modification by small protein conjugation or removalGO:1903321200.106
female gamete generationGO:0007292740.105
regulation of protein depolymerizationGO:1901879260.105
purine ribonucleoside monophosphate catabolic processGO:0009169570.105
regulation of microtubule cytoskeleton organizationGO:0070507370.104
Fly
muscle contractionGO:00069361010.104
mitochondrion localizationGO:005164690.103
Human Fly
mitotic cell cycle embryonicGO:004544850.103
regulation of release of cytochrome c from mitochondriaGO:0090199110.103
fertilizationGO:00095661270.103
negative regulation of cellular component organizationGO:00511291940.101
Human
epithelial cell proliferationGO:00506731740.100
cardiac muscle tissue developmentGO:00487381300.099
regulation of neuronal synaptic plasticityGO:0048168300.099
regulation of jnk cascadeGO:0046328620.098
regulation of cytoplasmic transportGO:19036491120.098
Human
maintenance of locationGO:0051235890.098
negative regulation of cellular amino acid metabolic processGO:004576300.097
oocyte developmentGO:0048599330.097
regulation of nucleocytoplasmic transportGO:0046822730.097
nuclear dna replicationGO:003326030.096
dna replicationGO:0006260520.096
purine nucleoside monophosphate catabolic processGO:0009128580.095
heart morphogenesisGO:00030071780.095
myeloid leukocyte activationGO:0002274830.094
amine metabolic processGO:0009308450.094
striated muscle contractionGO:0006941450.094
cerebral cortex developmentGO:0021987860.094
regulation of keratinocyte proliferationGO:0010837150.094
apoptotic signaling pathwayGO:00971903060.093
nuclear divisionGO:00002801580.093
actomyosin structure organizationGO:0031032560.093
regulation of cell migrationGO:00303342190.092
muscle tissue developmentGO:00605373080.091
establishment of skin barrierGO:0061436140.091
positive regulation of transferase activityGO:00513471670.091
Human
cell growth involved in cardiac muscle cell developmentGO:006104930.089
divalent inorganic cation homeostasisGO:00725071380.088
regulation of epidermal cell differentiationGO:0045604210.088
positive regulation of secretionGO:00510471300.086
oocyte differentiationGO:0009994350.086
negative regulation of protein depolymerizationGO:1901880210.086
keratinocyte proliferationGO:0043616210.085
positive regulation of stress activated mapk cascadeGO:0032874480.085
positive regulation of cellular catabolic processGO:00313311480.085
positive regulation of nucleotide metabolic processGO:00459811140.085
Human
second messenger mediated signalingGO:0019932730.085
protein modification by small protein conjugation or removalGO:00706472070.085
Human
jnk cascadeGO:0007254720.084
monocarboxylic acid metabolic processGO:00327871910.084
stress activated mapk cascadeGO:0051403800.083
extracellular matrix organizationGO:00301981470.082
asymmetric stem cell divisionGO:009872230.082
regulation of mitosisGO:0007088290.082
negative regulation of mitosisGO:0045839100.081
positive regulation of purine nucleotide metabolic processGO:19005441140.081
Human
positive regulation of cell adhesionGO:0045785800.081
germ cell developmentGO:00072811850.080
endomembrane system organizationGO:00102561470.079
regulation of stress activated mapk cascadeGO:0032872690.079
dna metabolic processGO:00062593030.079
regulation of actin filament depolymerizationGO:0030834130.079
water homeostasisGO:0030104270.078
cation transportGO:00068123990.076
negative regulation of dendrite developmentGO:200017190.076
pallium developmentGO:00215431200.076
regulation of epidermis developmentGO:0045682330.075
positive regulation of cell growthGO:0030307330.075
regulation of water loss via skinGO:0033561160.074
syncytium formationGO:0006949430.074
cell cycle checkpointGO:0000075470.074
multicellular organismal reproductive behaviorGO:0033057230.074
organic anion transportGO:00157111370.072
negative regulation of cytoskeleton organizationGO:0051494360.072
regulation of membrane potentialGO:00423911920.072
regulation of purine nucleotide metabolic processGO:19005421690.071
Human
regulation of erk1 and erk2 cascadeGO:0070372710.071
protein oligomerizationGO:0051259670.071
receptor mediated endocytosisGO:0006898510.070
positive regulation of cellular component biogenesisGO:0044089940.069
central nervous system neuron differentiationGO:00219531620.069
cell junction assemblyGO:0034329520.069
positive regulation of epidermal cell differentiationGO:004560660.069
divalent inorganic cation transportGO:00725111780.068
negative regulation of nuclear divisionGO:0051784190.068
negative regulation of epithelial cell proliferationGO:0050680640.067
regulation of epithelial cell proliferationGO:00506781410.067
response to organonitrogen compoundGO:00102432460.067
Human
posttranscriptional regulation of gene expressionGO:00106081550.067
protein localization to mitochondrionGO:0070585150.066
Human
epidermis developmentGO:00085441870.066
response to temperature stimulusGO:0009266550.066
negative regulation of phosphate metabolic processGO:00459361840.066
protein foldingGO:0006457280.066
exit from mitosisGO:001045830.065
organic acid transportGO:00158491010.065
extrinsic apoptotic signaling pathwayGO:00971911260.065
regulation of defense responseGO:00313472330.064
neutrophil mediated immunityGO:0002446190.064
regulation of proteasomal ubiquitin dependent protein catabolic processGO:0032434400.063
cell fate commitmentGO:00451652100.063
intrinsic apoptotic signaling pathwayGO:00971931320.062
muscle system processGO:00030121410.062
positive regulation of cellular amine metabolic processGO:003324050.062
positive regulation of fibroblast migrationGO:001076350.062
regulation of microtubule based processGO:0032886520.062
Fly
nuclear migrationGO:000709760.061
neural tube formationGO:00018411080.061
positive regulation of nucleoside metabolic processGO:0045979910.060
Human
cell maturationGO:00484691270.060
Human
chemotaxisGO:00069352470.060
Worm
fatty acid metabolic processGO:00066311210.060
nuclear exportGO:0051168340.059
anatomical structure homeostasisGO:00602491450.059
Mouse
protein catabolic processGO:00301632210.059
negative regulation of protein ubiquitinationGO:0031397190.059
establishment of mitochondrion localizationGO:005165440.058
synapse organizationGO:00508081250.058
Human Fly
cellular metal ion homeostasisGO:00068751510.058
circulatory system processGO:00030131970.058
dna integrity checkpointGO:0031570280.058
cellular protein complex disassemblyGO:0043624360.058
exocyst localizationGO:005160120.057
intracellular mrna localizationGO:000829840.056
regulation of cell cycleGO:00517262810.056
positive regulation of jnk cascadeGO:0046330460.056
sensory perceptionGO:00076002450.055
response to organic cyclic compoundGO:00140701980.055
Human
adherens junction assemblyGO:0034333220.055
dna damage checkpointGO:0000077260.055
positive regulation of substrate adhesion dependent cell spreadingGO:190002680.055
positive regulation of synaptic growth at neuromuscular junctionGO:004588710.055
exocytosisGO:00068871210.054
Human
stress activated protein kinase signaling cascadeGO:0031098810.054
regulated secretory pathwayGO:0045055320.054
protein localization to plasma membraneGO:0072659570.054
regulation of protein modification by small protein conjugation or removalGO:1903320570.054
Human
regulation of mitotic cell cycleGO:00073461260.054
positive regulation of protein modification processGO:00314012990.054
Human Mouse
mitotic cell cycleGO:00002781950.054
wnt signaling pathwayGO:00160551880.053
protein modification by small protein conjugationGO:00324461870.053
Human
multi multicellular organism processGO:00447061090.053
regulation of adrenergic receptor signaling pathwayGO:007187740.053
fibroblast migrationGO:0010761210.052
cellular ion homeostasisGO:00068731650.052
defense response to bacteriumGO:00427421190.052
genetic imprintingGO:0071514270.052
organic hydroxy compound metabolic processGO:19016152030.052
regulation of heart contractionGO:0008016770.052
sulfur compound biosynthetic processGO:0044272370.052
regulation of nuclear divisionGO:0051783560.052
canonical wnt signaling pathway involved in heart developmentGO:006131630.051
cellular lipid metabolic processGO:00442553230.051
establishment of mitotic spindle orientationGO:0000132120.051
adult behaviorGO:00305341350.051
platelet derived growth factor receptor signaling pathwayGO:0048008320.051
carboxylic acid transportGO:00469421000.051
reactive oxygen species metabolic processGO:0072593840.050
Human
muscle adaptationGO:0043500390.050
plasma membrane organizationGO:0007009900.050
multi organism reproductive behaviorGO:0044705290.049
negative regulation of protein complex assemblyGO:0031333250.049
regulation of map kinase activityGO:00434051200.049
Human
regulation of cellular ketone metabolic processGO:0010565660.049
positive regulation of lamellipodium assemblyGO:001059220.049
asymmetric cell divisionGO:000835680.048
axonogenesisGO:00074092740.048
Worm
positive regulation of cytoskeleton organizationGO:0051495490.048
calcineurin nfat signaling cascadeGO:003317380.048
cell fate determinationGO:0001709320.048
regulation of lamellipodium organizationGO:190274350.048
small molecule biosynthetic processGO:00442831320.047
signal transduction in absence of ligandGO:0038034550.047
dendrite developmentGO:00163581150.047
extrinsic apoptotic signaling pathway in absence of ligandGO:0097192550.047
negative regulation of cell proliferationGO:00082852960.047
necrotic cell deathGO:0070265300.047
blood circulationGO:00080151950.047
actin filament based movementGO:0030048230.047
arp2 3 complex mediated actin nucleationGO:003431430.046
positive regulation of protein phosphorylationGO:00019342420.046
Human Mouse
regulation of proteolysis involved in cellular protein catabolic processGO:1903050560.046
positive regulation of peptidyl serine phosphorylationGO:0033138250.046
myeloid leukocyte mediated immunityGO:0002444420.046
proteasome mediated ubiquitin dependent protein catabolic processGO:0043161880.045
negative regulation of cellular amine metabolic processGO:003323910.045
positive regulation of protein serine threonine kinase activityGO:00719021060.045
Human
protein complex disassemblyGO:0043241400.045
cardiac muscle contractionGO:0060048320.045
cellular response to peptideGO:1901653920.045
regulation of nucleotide metabolic processGO:00061401690.045
Human
regulation of microtubule polymerization or depolymerizationGO:0031110200.044
regulation of cell cycle processGO:00105641600.044
nucleocytoplasmic transportGO:00069131390.044
embryonic epithelial tube formationGO:00018381300.044
regulation of cell motilityGO:20001452360.044
innate immune responseGO:00450871570.044
multi organism behaviorGO:0051705620.044
regulation of bindingGO:00510981110.044
Human
synapse assemblyGO:0007416560.043
neural nucleus developmentGO:0048857220.043
regulation of protein dephosphorylationGO:003530440.043
positive regulation of actin filament polymerizationGO:0030838260.043
negative regulation of nfat protein import into nucleusGO:005153430.043

Lrrk2 disease predictions

Disease predictions are made from cross-annotation of human disease genes to the identified functional analogs in mouse and predicted with the mouse functional network.

DiseaseDO term IDSizeProbabilityFunc Analog Org
disease of anatomical entityDOID:700.221
Human
nervous system diseaseDOID:86300.221
Human
central nervous system diseaseDOID:33100.180
Human
sensory system diseaseDOID:005015500.056