Mus musculus

15 known processes

Tpp1

tripeptidyl peptidase I

(Aliases: Cln2,TPP-I)

Tpp1 biological process predictions


Filter by process size:
Biological processGO term IDProcess sizeProbabilityFunc Analog Org
protection from non homologous end joining at telomereGO:003184840.391
vacuole organizationGO:0007033380.196
membrane lipid biosynthetic processGO:0046467320.186
lysosome organizationGO:0007040210.169
anatomical structure homeostasisGO:00602491450.141
Human
negative regulation of protein metabolic processGO:00512482820.105
telomere maintenance in response to dna damageGO:004324740.104
cellular ketone metabolic processGO:0042180840.104
regulation of cellular amino acid metabolic processGO:000652150.076
sphingolipid catabolic processGO:003014970.076
sphingolipid metabolic processGO:0006665450.074
cellular lipid metabolic processGO:00442553230.066
organonitrogen compound catabolic processGO:19015652640.062
Human
sphingolipid biosynthetic processGO:0030148260.062
amine metabolic processGO:0009308450.061
triglyceride metabolic processGO:0006641510.061
ceramide biosynthetic processGO:0046513200.061
cellular amino acid metabolic processGO:00065201030.061
lytic vacuole organizationGO:0080171210.060
tissue homeostasisGO:00018941150.055
Human
regulation of cellular catabolic processGO:00313292420.050
regulation of body fluid levelsGO:00508781620.047
protein processingGO:00164851630.046
phospholipid transfer to membraneGO:000664920.045
wound healingGO:00420601570.041
lipid catabolic processGO:0016042690.041
ceramide metabolic processGO:0006672310.041
reactive oxygen species metabolic processGO:0072593840.038
apoptotic signaling pathwayGO:00971903060.037
sterol metabolic processGO:0016125580.037
macromolecule catabolic processGO:00090572810.035
regulation of apoptotic signaling pathwayGO:20012331970.035
oxidation reduction processGO:00551143420.034
sterol transportGO:0015918380.034
alcohol metabolic processGO:00060661160.033
regulation of peptidase activityGO:0052547960.033
carbohydrate derivative catabolic processGO:19011362310.033
negative regulation of cellular protein metabolic processGO:00322692470.032
regulation of removal of superoxide radicalsGO:200012140.032
anion transportGO:00068201770.031
cellular amine metabolic processGO:0044106440.031
transmembrane transportGO:00550854120.031
sensory perceptionGO:00076002450.030
neuronal action potentialGO:0019228540.029
peptidyl amino acid modificationGO:00181933360.029
regulation of phosphatidylcholine catabolic processGO:001089920.028
dna metabolic processGO:00062593030.027
endocytosisGO:00068971680.027
regulation of cellular amine metabolic processGO:0033238200.027
regulation of mapk cascadeGO:00434082480.027
multicellular organismal signalingGO:0035637910.026
cellular response to extracellular stimulusGO:0031668810.026
cation transmembrane transportGO:00986552660.026
ion transmembrane transportGO:00342203610.026
telomere cappingGO:001623340.025
regulation of membrane potentialGO:00423911920.025
male gamete generationGO:00482322850.025
regulation of systemic arterial blood pressure by carotid body chemoreceptor signalingGO:000302710.025
blood coagulationGO:0007596760.025
protein catabolic processGO:00301632210.025
glycolipid metabolic processGO:0006664250.025
response to organic cyclic compoundGO:00140701980.025
cholesterol metabolic processGO:0008203560.025
negative regulation of oxidative stress induced intrinsic apoptotic signaling pathwayGO:190217640.024
regulation of reactive oxygen species metabolic processGO:2000377400.024
single fertilizationGO:0007338820.024
negative regulation of glycoprotein metabolic processGO:190301930.024
positive regulation of mapk cascadeGO:00434101700.024
proteolysis involved in cellular protein catabolic processGO:00516031470.023
macroautophagyGO:0016236210.023
purine ribonucleoside metabolic processGO:00461282410.023
dna recombinationGO:0006310920.023
organophosphate catabolic processGO:00464342320.022
gland developmentGO:00487323300.022
organic hydroxy compound metabolic processGO:19016152030.022
circulatory system processGO:00030131970.022
glycosphingolipid catabolic processGO:004647950.022
mapk cascadeGO:00001652810.022
blastocyst hatchingGO:000183540.022
regulation of protein maturationGO:1903317960.022
dephosphorylationGO:00163111290.022
regulation of vesicle mediated transportGO:00606271390.021
natural killer cell degranulationGO:004332030.021
regulation of transferase activityGO:00513382630.021
protein kinase b signalingGO:0043491740.021
skin developmentGO:00435882200.021
nucleobase containing small molecule metabolic processGO:00550863520.021
ear developmentGO:00435832000.020
cellular response to external stimulusGO:0071496880.020
peptidyl tyrosine modificationGO:00182121450.020
regulation of proteolysisGO:00301621640.020
tissue remodelingGO:00487711020.020
Human
regulation of dna recombinationGO:0000018340.020
cholesterol homeostasisGO:0042632440.020
cellular macromolecule catabolic processGO:00442652060.020
multicellular organismal homeostasisGO:00488711640.019
Human
maintenance of locationGO:0051235890.019
amyloid precursor protein biosynthetic processGO:004298330.019
regulation of secretion by cellGO:19035302490.019
generation of precursor metabolites and energyGO:00060911030.019
positive regulation of cellular catabolic processGO:00313311480.019
regulation of amyloid precursor protein biosynthetic processGO:004298430.019
negative regulation of phosphate metabolic processGO:00459361840.019
hindbrain developmentGO:00309021280.019
blood circulationGO:00080151950.019
regulation of map kinase activityGO:00434051200.019
response to reactive oxygen speciesGO:0000302560.019
exocytosisGO:00068871210.018
cellular response to nutrient levelsGO:0031669640.018
regulation of cellular ketone metabolic processGO:0010565660.018
skeletal system developmentGO:00015013560.018
regulation of protein processingGO:0070613960.018
negative regulation of proteolysisGO:0045861740.018
regulation of defense responseGO:00313472330.018
regulation of ossificationGO:00302781120.018
negative regulation of protein maturationGO:1903318790.018
negative regulation of dna recombinationGO:0045910130.018
positive regulation of cellular amino acid metabolic processGO:004576430.018
epidermis developmentGO:00085441870.018
adult behaviorGO:00305341350.018
organelle localizationGO:00516401790.017
positive regulation of reactive oxygen species biosynthetic processGO:190342820.017
cytokine productionGO:00018163190.017
cellular response to thyroid hormone stimulusGO:009706710.017
reactive oxygen species biosynthetic processGO:190340980.017
purine nucleotide metabolic processGO:00061633020.017
transmembrane receptor protein serine threonine kinase signaling pathwayGO:00071781940.017
positive regulation of phagocytosisGO:0050766260.016
cation homeostasisGO:00550802120.016
cellular response to lipidGO:00713961450.016
lipid biosynthetic processGO:00086101790.016
cellular response to growth factor stimulusGO:00713631970.016
vesicle organizationGO:0016050600.016
membrane lipid catabolic processGO:004646680.016
positive regulation of membrane protein ectodomain proteolysisGO:005104430.016
ensheathment of neuronsGO:0007272760.016
negative regulation of molecular functionGO:00440922580.016
regulation of angiotensin levels in bloodGO:000200240.016
beta amyloid clearanceGO:009724220.016
nucleoside metabolic processGO:00091162460.016
negative regulation of intracellular signal transductionGO:19025321670.016
ribonucleoside metabolic processGO:00091192450.016
smoothened signaling pathwayGO:00072241050.016
sterol homeostasisGO:0055092450.016
regulation of blood pressureGO:0008217930.016
sphingosine metabolic processGO:000667040.016
regulation of beta amyloid clearanceGO:190022110.016
spermatogenesisGO:00072832840.016
positive regulation of macroautophagyGO:001623930.015
striated muscle tissue developmentGO:00147062930.015
ossificationGO:00015032160.015
leukocyte differentiationGO:00025213420.015
peptidyl tyrosine phosphorylationGO:00181081430.015
hair cycleGO:0042633900.015
nucleoside phosphate metabolic processGO:00067533380.015
regulation of plasma lipoprotein particle levelsGO:0097006230.015
posttranscriptional regulation of gene expressionGO:00106081550.015
fertilizationGO:00095661270.015
metal ion homeostasisGO:00550651890.015
regulation of reactive oxygen species biosynthetic processGO:190342620.015
positive regulation of protein modification processGO:00314012990.015
positive regulation of endocytosisGO:0045807420.015
response to acid chemicalGO:00011011110.015
placenta developmentGO:00018901400.014
organic hydroxy compound transportGO:0015850930.014
muscle tissue developmentGO:00605373080.014
transmission of nerve impulseGO:0019226760.014
biomineral tissue developmentGO:0031214640.014
endomembrane system organizationGO:00102561470.014
renal system developmentGO:00720012250.014
cell recognitionGO:0008037830.014
visual behaviorGO:0007632450.014
sensory perception of soundGO:0007605970.014
glycerolipid metabolic processGO:00464861220.014
myelinationGO:0042552740.014
kidney developmentGO:00018222130.014
epithelial cell proliferationGO:00506731740.014
embryonic placenta developmentGO:0001892980.014
response to light stimulusGO:00094161350.014
positive regulation of phagocytosis engulfmentGO:006010030.014
positive regulation of cytokine productionGO:00018191740.014
ribonucleotide metabolic processGO:00092592910.014
norepinephrine transportGO:001587420.014
positive regulation of secretionGO:00510471300.014
heart processGO:0003015940.014
liver developmentGO:0001889660.013
protein localization to vacuoleGO:007266540.013
organophosphate ester transportGO:0015748280.013
glycolipid catabolic processGO:001937750.013
purine ribonucleoside triphosphate catabolic processGO:00092071990.013
response to starvationGO:0042594650.013
regulation of lymphocyte mediated immunityGO:0002706840.013
positive regulation of coagulationGO:0050820130.013
symbiosis encompassing mutualism through parasitismGO:0044403830.013
homeostasis of number of cellsGO:00488722100.013
positive regulation of reactive oxygen species metabolic processGO:2000379110.013
lipoprotein metabolic processGO:0042157430.013
aminoglycan metabolic processGO:0006022340.013
nucleotide metabolic processGO:00091173320.013
negative regulation of protein processingGO:0010955790.013
cellular homeostasisGO:00197252400.013
leukocyte mediated immunityGO:00024431740.013
heart morphogenesisGO:00030071780.013
regulation of excitatory postsynaptic membrane potentialGO:0060079410.013
sulfur compound metabolic processGO:00067901000.013
cell type specific apoptotic processGO:00972852680.013
skeletal system morphogenesisGO:00487052030.013
cellular response to molecule of bacterial originGO:0071219830.013
hepatocyte growth factor receptor signaling pathwayGO:004801230.013
ras protein signal transductionGO:0007265770.013
positive regulation of lymphocyte activationGO:00512511400.013
lipid localizationGO:00108761260.013
regulation of cellular response to stressGO:00801351590.013
regulation of cytokine productionGO:00018172660.013
establishment of vesicle localizationGO:0051650810.013
ribonucleoside triphosphate metabolic processGO:00091992200.013
interspecies interaction between organismsGO:0044419830.013
carbohydrate derivative biosynthetic processGO:19011371830.012
fatty acid metabolic processGO:00066311210.012
negative regulation of neuron apoptotic processGO:0043524920.012
plasma membrane organizationGO:0007009900.012
sensory organ morphogenesisGO:00905962420.012
atp catabolic processGO:0006200550.012
positive regulation of dna templated transcription elongationGO:003278620.012
regulation of cell cycle processGO:00105641600.012
regulation of system processGO:00440572000.012
lipid transportGO:0006869980.012
negative regulation of transferase activityGO:0051348850.012
negative regulation of glycoprotein biosynthetic processGO:001056130.012
glycosyl compound catabolic processGO:19016582060.012
plasma lipoprotein particle clearanceGO:0034381130.012
glycerophospholipid metabolic processGO:0006650710.012
cellular response to starvationGO:0009267570.012
interleukin 6 productionGO:0032635580.012
nucleoside monophosphate metabolic processGO:0009123850.012
negative regulation of hydrolase activityGO:0051346710.012
bone mineralizationGO:0030282540.012
molting cycleGO:0042303900.012
cellular response to oxygen radicalGO:0071450140.012
regulation of protein kinase activityGO:00458592320.012
regulation of cellular response to growth factor stimulusGO:0090287820.012
cytokinetic processGO:003250620.012
cerebellum developmentGO:0021549770.012
lung developmentGO:00303241640.012
skeletal muscle organ developmentGO:00605381630.012
purine ribonucleoside monophosphate metabolic processGO:0009167800.012
nucleoside triphosphate metabolic processGO:00091412300.011
positive regulation of cell killingGO:0031343330.011
regulation of protein serine threonine kinase activityGO:00719001570.011
regulation of tumor necrosis factor superfamily cytokine productionGO:1903555500.011
inorganic cation transmembrane transportGO:00986622070.011
pharynx developmentGO:006046510.011
regulation of hydrolase activityGO:00513362460.011
metencephalon developmentGO:0022037890.011
muscle contractionGO:00069361010.011
neuromuscular process controlling balanceGO:0050885590.011
atp metabolic processGO:0046034750.011
organonitrogen compound biosynthetic processGO:19015661920.011
immune effector processGO:00022523210.011
cellular response to organonitrogen compoundGO:00714171450.011
embryonic organ morphogenesisGO:00485622760.011
negative regulation of phosphorylationGO:00423261660.011
purine ribonucleoside triphosphate metabolic processGO:00092052200.011
organism emergence from protective structureGO:007168440.011
regulation of organelle organizationGO:00330432890.011
cellular divalent inorganic cation homeostasisGO:00725031270.011
regulation of multi organism processGO:00439001110.011
locomotory behaviorGO:00076261950.011
Zebrafish
response to molecule of bacterial originGO:00022371430.011
wnt signaling pathwayGO:00160551880.011
cellular lipid catabolic processGO:0044242520.011
developmental cell growthGO:0048588840.011
regulation of neuron apoptotic processGO:00435231220.011
regulation of cellular protein catabolic processGO:1903362610.011
neutral lipid metabolic processGO:0006638570.011
action potentialGO:0001508780.011
positive regulation of homeostatic processGO:0032846640.011
regulation of bone resorptionGO:0045124240.011
positive regulation of response to woundingGO:1903036660.011
negative regulation of type b pancreatic cell apoptotic processGO:200067530.011
positive regulation of transferase activityGO:00513471670.011
cofactor transportGO:005118140.011
positive regulation of protein serine threonine kinase activityGO:00719021060.011
regulation of cell cycleGO:00517262810.011
rho protein signal transductionGO:0007266320.011
regulation of cell activationGO:00508652890.010
leukocyte migrationGO:00509001240.010
regulation of wnt signaling pathwayGO:00301111230.010
purine nucleoside metabolic processGO:00422782410.010
erk1 and erk2 cascadeGO:0070371770.010
nitrogen compound transportGO:00717052710.010
receptor mediated endocytosisGO:0006898510.010
purine nucleoside triphosphate metabolic processGO:00091442260.010
isoprenoid metabolic processGO:0006720290.010
gliogenesisGO:00420631410.010
dopamine catabolic processGO:004242040.010
hemostasisGO:0007599780.010
phospholipid metabolic processGO:0006644870.010
intrinsic apoptotic signaling pathwayGO:00971931320.010
hatchingGO:003518840.010
adult locomotory behaviorGO:0008344910.010
small gtpase mediated signal transductionGO:0007264970.010
positive regulation of cholesterol storageGO:001088630.010
purine ribonucleotide catabolic processGO:00091542080.010
positive regulation of reverse cholesterol transportGO:190306410.010
positive regulation of apoptotic signaling pathwayGO:2001235950.010
inflammatory responseGO:00069542440.010
vitamin metabolic processGO:0006766230.010
regulation of secretionGO:00510462740.010
pigmentationGO:0043473710.010
regulation of leukocyte mediated immunityGO:00027031040.010
cellular response to biotic stimulusGO:0071216920.010

Tpp1 disease predictions

Disease predictions are made from cross-annotation of human disease genes to the identified functional analogs in mouse and predicted with the mouse functional network.

DiseaseDO term IDSizeProbabilityFunc Analog Org
inherited metabolic disorderDOID:65500.966
Human
disease of metabolismDOID:001466700.966
Human
lysosomal storage diseaseDOID:321100.700
Human
sphingolipidosisDOID:192700.700
lipid storage diseaseDOID:945500.700
Human
sensory system diseaseDOID:005015500.059
nervous system diseaseDOID:86300.059
disease of anatomical entityDOID:700.059
retinal diseaseDOID:567900.045
eye and adnexa diseaseDOID:149200.045
eye diseaseDOID:561400.045
immune system diseaseDOID:291400.038
central nervous system diseaseDOID:33100.036
brain diseaseDOID:93600.027
lymphatic system diseaseDOID:7500.026
retinal degenerationDOID:846600.014
acquired metabolic diseaseDOID:006015800.013
cognitive disorderDOID:156100.013
disease of mental healthDOID:15000.013
dementiaDOID:130700.013
bone diseaseDOID:008000100.011
connective tissue diseaseDOID:6500.011
musculoskeletal system diseaseDOID:1700.011
electroclinical syndromeDOID:005070100.011
epilepsy syndromeDOID:182600.011