IMP: Integrative Multi-species Prediction

Mus musculus

15 known processes

Tpp1

tripeptidyl peptidase I

(Aliases: Cln2,TPP-I)

Ensembl: ENSMUSG00000030894
Entrez: 12751
UniProtKB: O89023

Process Predictions
Disease Predictions

Tpp1 biological process predictions

Show only novel predictionsHighlight processes of functional analogs

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Biological process	GO term ID	Process size	Probability	Func Analog Org
protection from non homologous end joining at telomere	GO:0031848	4	0.391
vacuole organization	GO:0007033	38	0.196
membrane lipid biosynthetic process	GO:0046467	32	0.186
lysosome organization	GO:0007040	21	0.169
anatomical structure homeostasis	GO:0060249	145	0.141	Human
negative regulation of protein metabolic process	GO:0051248	282	0.105
telomere maintenance in response to dna damage	GO:0043247	4	0.104
cellular ketone metabolic process	GO:0042180	84	0.104
regulation of cellular amino acid metabolic process	GO:0006521	5	0.076
sphingolipid catabolic process	GO:0030149	7	0.076
sphingolipid metabolic process	GO:0006665	45	0.074
cellular lipid metabolic process	GO:0044255	323	0.066
organonitrogen compound catabolic process	GO:1901565	264	0.062	Human
sphingolipid biosynthetic process	GO:0030148	26	0.062
amine metabolic process	GO:0009308	45	0.061
triglyceride metabolic process	GO:0006641	51	0.061
ceramide biosynthetic process	GO:0046513	20	0.061
cellular amino acid metabolic process	GO:0006520	103	0.061
lytic vacuole organization	GO:0080171	21	0.060
tissue homeostasis	GO:0001894	115	0.055	Human
regulation of cellular catabolic process	GO:0031329	242	0.050
regulation of body fluid levels	GO:0050878	162	0.047
protein processing	GO:0016485	163	0.046
phospholipid transfer to membrane	GO:0006649	2	0.045
wound healing	GO:0042060	157	0.041
lipid catabolic process	GO:0016042	69	0.041
ceramide metabolic process	GO:0006672	31	0.041
reactive oxygen species metabolic process	GO:0072593	84	0.038
apoptotic signaling pathway	GO:0097190	306	0.037
sterol metabolic process	GO:0016125	58	0.037
macromolecule catabolic process	GO:0009057	281	0.035
regulation of apoptotic signaling pathway	GO:2001233	197	0.035
oxidation reduction process	GO:0055114	342	0.034
sterol transport	GO:0015918	38	0.034
alcohol metabolic process	GO:0006066	116	0.033
regulation of peptidase activity	GO:0052547	96	0.033
carbohydrate derivative catabolic process	GO:1901136	231	0.033
negative regulation of cellular protein metabolic process	GO:0032269	247	0.032
regulation of removal of superoxide radicals	GO:2000121	4	0.032
anion transport	GO:0006820	177	0.031
cellular amine metabolic process	GO:0044106	44	0.031
transmembrane transport	GO:0055085	412	0.031
sensory perception	GO:0007600	245	0.030
neuronal action potential	GO:0019228	54	0.029
peptidyl amino acid modification	GO:0018193	336	0.029
regulation of phosphatidylcholine catabolic process	GO:0010899	2	0.028
dna metabolic process	GO:0006259	303	0.027
endocytosis	GO:0006897	168	0.027
regulation of cellular amine metabolic process	GO:0033238	20	0.027
regulation of mapk cascade	GO:0043408	248	0.027
multicellular organismal signaling	GO:0035637	91	0.026
cellular response to extracellular stimulus	GO:0031668	81	0.026
cation transmembrane transport	GO:0098655	266	0.026
ion transmembrane transport	GO:0034220	361	0.026
telomere capping	GO:0016233	4	0.025
regulation of membrane potential	GO:0042391	192	0.025
male gamete generation	GO:0048232	285	0.025
regulation of systemic arterial blood pressure by carotid body chemoreceptor signaling	GO:0003027	1	0.025
blood coagulation	GO:0007596	76	0.025
protein catabolic process	GO:0030163	221	0.025
glycolipid metabolic process	GO:0006664	25	0.025
response to organic cyclic compound	GO:0014070	198	0.025
cholesterol metabolic process	GO:0008203	56	0.025
negative regulation of oxidative stress induced intrinsic apoptotic signaling pathway	GO:1902176	4	0.024
regulation of reactive oxygen species metabolic process	GO:2000377	40	0.024
single fertilization	GO:0007338	82	0.024
negative regulation of glycoprotein metabolic process	GO:1903019	3	0.024
positive regulation of mapk cascade	GO:0043410	170	0.024
proteolysis involved in cellular protein catabolic process	GO:0051603	147	0.023
macroautophagy	GO:0016236	21	0.023
purine ribonucleoside metabolic process	GO:0046128	241	0.023
dna recombination	GO:0006310	92	0.023
organophosphate catabolic process	GO:0046434	232	0.022
gland development	GO:0048732	330	0.022
organic hydroxy compound metabolic process	GO:1901615	203	0.022
circulatory system process	GO:0003013	197	0.022
glycosphingolipid catabolic process	GO:0046479	5	0.022
mapk cascade	GO:0000165	281	0.022
blastocyst hatching	GO:0001835	4	0.022
regulation of protein maturation	GO:1903317	96	0.022
dephosphorylation	GO:0016311	129	0.022
regulation of vesicle mediated transport	GO:0060627	139	0.021
natural killer cell degranulation	GO:0043320	3	0.021
regulation of transferase activity	GO:0051338	263	0.021
protein kinase b signaling	GO:0043491	74	0.021
skin development	GO:0043588	220	0.021
nucleobase containing small molecule metabolic process	GO:0055086	352	0.021
ear development	GO:0043583	200	0.020
cellular response to external stimulus	GO:0071496	88	0.020
peptidyl tyrosine modification	GO:0018212	145	0.020
regulation of proteolysis	GO:0030162	164	0.020
tissue remodeling	GO:0048771	102	0.020	Human
regulation of dna recombination	GO:0000018	34	0.020
cholesterol homeostasis	GO:0042632	44	0.020
cellular macromolecule catabolic process	GO:0044265	206	0.020
multicellular organismal homeostasis	GO:0048871	164	0.019	Human
maintenance of location	GO:0051235	89	0.019
amyloid precursor protein biosynthetic process	GO:0042983	3	0.019
regulation of secretion by cell	GO:1903530	249	0.019
generation of precursor metabolites and energy	GO:0006091	103	0.019
positive regulation of cellular catabolic process	GO:0031331	148	0.019
regulation of amyloid precursor protein biosynthetic process	GO:0042984	3	0.019
negative regulation of phosphate metabolic process	GO:0045936	184	0.019
hindbrain development	GO:0030902	128	0.019
blood circulation	GO:0008015	195	0.019
regulation of map kinase activity	GO:0043405	120	0.019
response to reactive oxygen species	GO:0000302	56	0.019
exocytosis	GO:0006887	121	0.018
cellular response to nutrient levels	GO:0031669	64	0.018
regulation of cellular ketone metabolic process	GO:0010565	66	0.018
skeletal system development	GO:0001501	356	0.018
regulation of protein processing	GO:0070613	96	0.018
negative regulation of proteolysis	GO:0045861	74	0.018
regulation of defense response	GO:0031347	233	0.018
regulation of ossification	GO:0030278	112	0.018
negative regulation of protein maturation	GO:1903318	79	0.018
negative regulation of dna recombination	GO:0045910	13	0.018
positive regulation of cellular amino acid metabolic process	GO:0045764	3	0.018
epidermis development	GO:0008544	187	0.018
adult behavior	GO:0030534	135	0.018
organelle localization	GO:0051640	179	0.017
positive regulation of reactive oxygen species biosynthetic process	GO:1903428	2	0.017
cytokine production	GO:0001816	319	0.017
cellular response to thyroid hormone stimulus	GO:0097067	1	0.017
reactive oxygen species biosynthetic process	GO:1903409	8	0.017
purine nucleotide metabolic process	GO:0006163	302	0.017
transmembrane receptor protein serine threonine kinase signaling pathway	GO:0007178	194	0.017
positive regulation of phagocytosis	GO:0050766	26	0.016
cation homeostasis	GO:0055080	212	0.016
cellular response to lipid	GO:0071396	145	0.016
lipid biosynthetic process	GO:0008610	179	0.016
cellular response to growth factor stimulus	GO:0071363	197	0.016
vesicle organization	GO:0016050	60	0.016
membrane lipid catabolic process	GO:0046466	8	0.016
positive regulation of membrane protein ectodomain proteolysis	GO:0051044	3	0.016
ensheathment of neurons	GO:0007272	76	0.016
negative regulation of molecular function	GO:0044092	258	0.016
regulation of angiotensin levels in blood	GO:0002002	4	0.016
beta amyloid clearance	GO:0097242	2	0.016
nucleoside metabolic process	GO:0009116	246	0.016
negative regulation of intracellular signal transduction	GO:1902532	167	0.016
ribonucleoside metabolic process	GO:0009119	245	0.016
smoothened signaling pathway	GO:0007224	105	0.016
sterol homeostasis	GO:0055092	45	0.016
regulation of blood pressure	GO:0008217	93	0.016
sphingosine metabolic process	GO:0006670	4	0.016
regulation of beta amyloid clearance	GO:1900221	1	0.016
spermatogenesis	GO:0007283	284	0.016
positive regulation of macroautophagy	GO:0016239	3	0.015
striated muscle tissue development	GO:0014706	293	0.015
ossification	GO:0001503	216	0.015
leukocyte differentiation	GO:0002521	342	0.015
peptidyl tyrosine phosphorylation	GO:0018108	143	0.015
hair cycle	GO:0042633	90	0.015
nucleoside phosphate metabolic process	GO:0006753	338	0.015
regulation of plasma lipoprotein particle levels	GO:0097006	23	0.015
posttranscriptional regulation of gene expression	GO:0010608	155	0.015
fertilization	GO:0009566	127	0.015
metal ion homeostasis	GO:0055065	189	0.015
regulation of reactive oxygen species biosynthetic process	GO:1903426	2	0.015
positive regulation of protein modification process	GO:0031401	299	0.015
positive regulation of endocytosis	GO:0045807	42	0.015
response to acid chemical	GO:0001101	111	0.015
placenta development	GO:0001890	140	0.014
organic hydroxy compound transport	GO:0015850	93	0.014
muscle tissue development	GO:0060537	308	0.014
transmission of nerve impulse	GO:0019226	76	0.014
biomineral tissue development	GO:0031214	64	0.014
endomembrane system organization	GO:0010256	147	0.014
renal system development	GO:0072001	225	0.014
cell recognition	GO:0008037	83	0.014
visual behavior	GO:0007632	45	0.014
sensory perception of sound	GO:0007605	97	0.014
glycerolipid metabolic process	GO:0046486	122	0.014
myelination	GO:0042552	74	0.014
kidney development	GO:0001822	213	0.014
epithelial cell proliferation	GO:0050673	174	0.014
embryonic placenta development	GO:0001892	98	0.014
response to light stimulus	GO:0009416	135	0.014
positive regulation of phagocytosis engulfment	GO:0060100	3	0.014
positive regulation of cytokine production	GO:0001819	174	0.014
ribonucleotide metabolic process	GO:0009259	291	0.014
norepinephrine transport	GO:0015874	2	0.014
positive regulation of secretion	GO:0051047	130	0.014
heart process	GO:0003015	94	0.014
liver development	GO:0001889	66	0.013
protein localization to vacuole	GO:0072665	4	0.013
organophosphate ester transport	GO:0015748	28	0.013
glycolipid catabolic process	GO:0019377	5	0.013
purine ribonucleoside triphosphate catabolic process	GO:0009207	199	0.013
response to starvation	GO:0042594	65	0.013
regulation of lymphocyte mediated immunity	GO:0002706	84	0.013
positive regulation of coagulation	GO:0050820	13	0.013
symbiosis encompassing mutualism through parasitism	GO:0044403	83	0.013
homeostasis of number of cells	GO:0048872	210	0.013
positive regulation of reactive oxygen species metabolic process	GO:2000379	11	0.013
lipoprotein metabolic process	GO:0042157	43	0.013
aminoglycan metabolic process	GO:0006022	34	0.013
nucleotide metabolic process	GO:0009117	332	0.013
negative regulation of protein processing	GO:0010955	79	0.013
cellular homeostasis	GO:0019725	240	0.013
leukocyte mediated immunity	GO:0002443	174	0.013
heart morphogenesis	GO:0003007	178	0.013
regulation of excitatory postsynaptic membrane potential	GO:0060079	41	0.013
sulfur compound metabolic process	GO:0006790	100	0.013
cell type specific apoptotic process	GO:0097285	268	0.013
skeletal system morphogenesis	GO:0048705	203	0.013
cellular response to molecule of bacterial origin	GO:0071219	83	0.013
hepatocyte growth factor receptor signaling pathway	GO:0048012	3	0.013
ras protein signal transduction	GO:0007265	77	0.013
positive regulation of lymphocyte activation	GO:0051251	140	0.013
lipid localization	GO:0010876	126	0.013
regulation of cellular response to stress	GO:0080135	159	0.013
regulation of cytokine production	GO:0001817	266	0.013
establishment of vesicle localization	GO:0051650	81	0.013
ribonucleoside triphosphate metabolic process	GO:0009199	220	0.013
interspecies interaction between organisms	GO:0044419	83	0.013
carbohydrate derivative biosynthetic process	GO:1901137	183	0.012
fatty acid metabolic process	GO:0006631	121	0.012
negative regulation of neuron apoptotic process	GO:0043524	92	0.012
plasma membrane organization	GO:0007009	90	0.012
sensory organ morphogenesis	GO:0090596	242	0.012
atp catabolic process	GO:0006200	55	0.012
positive regulation of dna templated transcription elongation	GO:0032786	2	0.012
regulation of cell cycle process	GO:0010564	160	0.012
regulation of system process	GO:0044057	200	0.012
lipid transport	GO:0006869	98	0.012
negative regulation of transferase activity	GO:0051348	85	0.012
negative regulation of glycoprotein biosynthetic process	GO:0010561	3	0.012
glycosyl compound catabolic process	GO:1901658	206	0.012
plasma lipoprotein particle clearance	GO:0034381	13	0.012
glycerophospholipid metabolic process	GO:0006650	71	0.012
cellular response to starvation	GO:0009267	57	0.012
interleukin 6 production	GO:0032635	58	0.012
nucleoside monophosphate metabolic process	GO:0009123	85	0.012
negative regulation of hydrolase activity	GO:0051346	71	0.012
bone mineralization	GO:0030282	54	0.012
molting cycle	GO:0042303	90	0.012
cellular response to oxygen radical	GO:0071450	14	0.012
regulation of protein kinase activity	GO:0045859	232	0.012
regulation of cellular response to growth factor stimulus	GO:0090287	82	0.012
cytokinetic process	GO:0032506	2	0.012
cerebellum development	GO:0021549	77	0.012
lung development	GO:0030324	164	0.012
skeletal muscle organ development	GO:0060538	163	0.012
purine ribonucleoside monophosphate metabolic process	GO:0009167	80	0.012
nucleoside triphosphate metabolic process	GO:0009141	230	0.011
positive regulation of cell killing	GO:0031343	33	0.011
regulation of protein serine threonine kinase activity	GO:0071900	157	0.011
regulation of tumor necrosis factor superfamily cytokine production	GO:1903555	50	0.011
inorganic cation transmembrane transport	GO:0098662	207	0.011
pharynx development	GO:0060465	1	0.011
regulation of hydrolase activity	GO:0051336	246	0.011
metencephalon development	GO:0022037	89	0.011
muscle contraction	GO:0006936	101	0.011
neuromuscular process controlling balance	GO:0050885	59	0.011
atp metabolic process	GO:0046034	75	0.011
organonitrogen compound biosynthetic process	GO:1901566	192	0.011
immune effector process	GO:0002252	321	0.011
cellular response to organonitrogen compound	GO:0071417	145	0.011
embryonic organ morphogenesis	GO:0048562	276	0.011
negative regulation of phosphorylation	GO:0042326	166	0.011
purine ribonucleoside triphosphate metabolic process	GO:0009205	220	0.011
organism emergence from protective structure	GO:0071684	4	0.011
regulation of organelle organization	GO:0033043	289	0.011
cellular divalent inorganic cation homeostasis	GO:0072503	127	0.011
regulation of multi organism process	GO:0043900	111	0.011
locomotory behavior	GO:0007626	195	0.011	Zebrafish
response to molecule of bacterial origin	GO:0002237	143	0.011
wnt signaling pathway	GO:0016055	188	0.011
cellular lipid catabolic process	GO:0044242	52	0.011
developmental cell growth	GO:0048588	84	0.011
regulation of neuron apoptotic process	GO:0043523	122	0.011
regulation of cellular protein catabolic process	GO:1903362	61	0.011
neutral lipid metabolic process	GO:0006638	57	0.011
action potential	GO:0001508	78	0.011
positive regulation of homeostatic process	GO:0032846	64	0.011
regulation of bone resorption	GO:0045124	24	0.011
positive regulation of response to wounding	GO:1903036	66	0.011
negative regulation of type b pancreatic cell apoptotic process	GO:2000675	3	0.011
positive regulation of transferase activity	GO:0051347	167	0.011
cofactor transport	GO:0051181	4	0.011
positive regulation of protein serine threonine kinase activity	GO:0071902	106	0.011
regulation of cell cycle	GO:0051726	281	0.011
rho protein signal transduction	GO:0007266	32	0.011
regulation of cell activation	GO:0050865	289	0.010
leukocyte migration	GO:0050900	124	0.010
regulation of wnt signaling pathway	GO:0030111	123	0.010
purine nucleoside metabolic process	GO:0042278	241	0.010
erk1 and erk2 cascade	GO:0070371	77	0.010
nitrogen compound transport	GO:0071705	271	0.010
receptor mediated endocytosis	GO:0006898	51	0.010
purine nucleoside triphosphate metabolic process	GO:0009144	226	0.010
isoprenoid metabolic process	GO:0006720	29	0.010
gliogenesis	GO:0042063	141	0.010
dopamine catabolic process	GO:0042420	4	0.010
hemostasis	GO:0007599	78	0.010
phospholipid metabolic process	GO:0006644	87	0.010
intrinsic apoptotic signaling pathway	GO:0097193	132	0.010
hatching	GO:0035188	4	0.010
adult locomotory behavior	GO:0008344	91	0.010
small gtpase mediated signal transduction	GO:0007264	97	0.010
positive regulation of cholesterol storage	GO:0010886	3	0.010
purine ribonucleotide catabolic process	GO:0009154	208	0.010
positive regulation of reverse cholesterol transport	GO:1903064	1	0.010
positive regulation of apoptotic signaling pathway	GO:2001235	95	0.010
inflammatory response	GO:0006954	244	0.010
vitamin metabolic process	GO:0006766	23	0.010
regulation of secretion	GO:0051046	274	0.010
pigmentation	GO:0043473	71	0.010
regulation of leukocyte mediated immunity	GO:0002703	104	0.010
cellular response to biotic stimulus	GO:0071216	92	0.010

Tpp1 disease predictions

Disease predictions are made from cross-annotation of human disease genes to the identified functional analogs in mouse and predicted with the mouse functional network.

Disease	DO term ID	Probability	Func Analog Org
inherited metabolic disorder	DOID:655	0.966	Human
disease of metabolism	DOID:0014667	0.966	Human
lysosomal storage disease	DOID:3211	0.700	Human
sphingolipidosis	DOID:1927	0.700
lipid storage disease	DOID:9455	0.700	Human
sensory system disease	DOID:0050155	0.059
nervous system disease	DOID:863	0.059
disease of anatomical entity	DOID:7	0.059
retinal disease	DOID:5679	0.045
eye and adnexa disease	DOID:1492	0.045
eye disease	DOID:5614	0.045
immune system disease	DOID:2914	0.038
central nervous system disease	DOID:331	0.036
brain disease	DOID:936	0.027
lymphatic system disease	DOID:75	0.026
retinal degeneration	DOID:8466	0.014
acquired metabolic disease	DOID:0060158	0.013
cognitive disorder	DOID:1561	0.013
disease of mental health	DOID:150	0.013
dementia	DOID:1307	0.013
bone disease	DOID:0080001	0.011
connective tissue disease	DOID:65	0.011
musculoskeletal system disease	DOID:17	0.011
electroclinical syndrome	DOID:0050701	0.011
epilepsy syndrome	DOID:1826	0.011

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