IMP: Integrative Multi-species Prediction

Mus musculus

71 known processes

Itgal

integrin alpha L

(Aliases: Ly-21,LFA-1,Cd11a,Ly-15)

Ensembl: ENSMUSG00000030830
Entrez: 16408
UniProtKB: E9QNL8
UniProtKB: B7ZN92
UniProtKB: E9Q5M7
UniProtKB: Q3TB85

Process Predictions
Disease Predictions

Itgal biological process predictions

Show only novel predictionsHighlight processes of functional analogs

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Biological process	GO term ID	Process size	Probability	Func Analog Org
extrinsic apoptotic signaling pathway	GO:0097191	126	0.975	Mouse
leukocyte mediated immunity	GO:0002443	174	0.942
leukocyte differentiation	GO:0002521	342	0.938	Mouse
defense response to other organism	GO:0098542	197	0.933	Mouse
regulation of cytokine production	GO:0001817	266	0.911
immune effector process	GO:0002252	321	0.896	Human Mouse
regulation of innate immune response	GO:0045088	91	0.896
immune response activating cell surface receptor signaling pathway	GO:0002429	72	0.887
apoptotic signaling pathway	GO:0097190	306	0.884	Mouse
regulation of cell activation	GO:0050865	289	0.864
neuron projection guidance	GO:0097485	141	0.826	Fly
negative regulation of immune system process	GO:0002683	209	0.818
chemotaxis	GO:0006935	247	0.813	Mouse Fly
myeloid cell differentiation	GO:0030099	233	0.813	Mouse
t cell activation	GO:0042110	289	0.801
cytokine production	GO:0001816	319	0.792
cellular extravasation	GO:0045123	17	0.779	Mouse
leukocyte migration	GO:0050900	124	0.735	Mouse
defense response to gram positive bacterium	GO:0050830	50	0.729
leukocyte activation involved in immune response	GO:0002366	126	0.728	Human
antigen receptor mediated signaling pathway	GO:0050851	64	0.723
positive regulation of lymphocyte activation	GO:0051251	140	0.717
adaptive immune response based on somatic recombination of immune receptors built from immunoglobulin superfamily domains	GO:0002460	145	0.707
blood vessel morphogenesis	GO:0048514	285	0.707	Mouse
regulation of t cell proliferation	GO:0042129	92	0.688
positive regulation of cytokine production	GO:0001819	174	0.676
positive regulation of cell migration	GO:0030335	109	0.669	Mouse
positive regulation of t cell activation	GO:0050870	101	0.666
peptidyl amino acid modification	GO:0018193	336	0.651
response to molecule of bacterial origin	GO:0002237	143	0.650
ras protein signal transduction	GO:0007265	77	0.630	Mouse
regulation of leukocyte mediated immunity	GO:0002703	104	0.620
leukocyte proliferation	GO:0070661	172	0.598
regulation of cell migration	GO:0030334	219	0.596	Mouse Fly
rho protein signal transduction	GO:0007266	32	0.595	Mouse
lymphocyte differentiation	GO:0030098	242	0.592
b cell activation	GO:0042113	161	0.591
immune response activating signal transduction	GO:0002757	116	0.591
regulation of synaptic growth at neuromuscular junction	GO:0008582	4	0.589	Fly
immune response regulating cell surface receptor signaling pathway	GO:0002768	80	0.579
myeloid leukocyte activation	GO:0002274	83	0.564
regulation of adaptive immune response	GO:0002819	90	0.564
t cell differentiation	GO:0030217	174	0.559
inflammatory response	GO:0006954	244	0.554	Mouse
innate immune response	GO:0045087	157	0.543
positive regulation of cellular amine metabolic process	GO:0033240	5	0.537
cytokine mediated signaling pathway	GO:0019221	115	0.535
adaptive immune response	GO:0002250	155	0.530
activation of immune response	GO:0002253	138	0.527
negative thymic t cell selection	GO:0045060	12	0.527
myeloid leukocyte differentiation	GO:0002573	119	0.521	Mouse
digestive tract development	GO:0048565	190	0.515
regulation of cellular ketone metabolic process	GO:0010565	66	0.509
lymphocyte migration	GO:0072676	26	0.509	Mouse
cell activation involved in immune response	GO:0002263	126	0.503	Human
cellular response to cytokine stimulus	GO:0071345	189	0.499
immune response regulating signaling pathway	GO:0002764	125	0.497
regionalization	GO:0003002	337	0.494
membrane organization	GO:0061024	245	0.488	Human
axon guidance	GO:0007411	141	0.478	Fly
granulocyte migration	GO:0097530	43	0.477	Mouse
angiogenesis	GO:0001525	201	0.467
cell type specific apoptotic process	GO:0097285	268	0.462
regulation of defense response	GO:0031347	233	0.449
granulocyte chemotaxis	GO:0071621	39	0.444	Mouse
regulation of cellular amino acid metabolic process	GO:0006521	5	0.441
positive regulation of monocyte extravasation	GO:2000439	1	0.438
regulation of cellular amine metabolic process	GO:0033238	20	0.435
positive regulation of t cell extravasation	GO:2000409	2	0.428
t cell receptor signaling pathway	GO:0050852	46	0.426
peptidyl tyrosine modification	GO:0018212	145	0.425
cell fate commitment	GO:0045165	210	0.421
positive regulation of cytokine biosynthetic process	GO:0042108	40	0.421
alpha beta t cell activation	GO:0046631	91	0.416
regulation of lymphocyte activation	GO:0051249	240	0.414
regulation of cytokine biosynthetic process	GO:0042035	59	0.412
cell chemotaxis	GO:0060326	81	0.410	Mouse
regulation of reactive oxygen species biosynthetic process	GO:1903426	2	0.405
leukocyte cell cell adhesion	GO:0007159	14	0.404
regulation of t cell costimulation	GO:2000523	2	0.401
positive regulation of cd8 positive alpha beta t cell extravasation	GO:2000451	2	0.398
t cell proliferation	GO:0042098	120	0.397
negative regulation of synapse assembly	GO:0051964	3	0.391	Fly
cellular amine metabolic process	GO:0044106	44	0.390
negative regulation of extrinsic apoptotic signaling pathway	GO:2001237	45	0.388
regulation of interferon gamma production	GO:0032649	57	0.385
reactive oxygen species metabolic process	GO:0072593	84	0.379
positive regulation of cell activation	GO:0050867	158	0.379
myeloid leukocyte mediated immunity	GO:0002444	42	0.371
pattern recognition receptor signaling pathway	GO:0002221	47	0.371
positive regulation of protein modification process	GO:0031401	299	0.369
cellular response to biotic stimulus	GO:0071216	92	0.367
mapk cascade	GO:0000165	281	0.366	Mouse
negative regulation of apoptotic signaling pathway	GO:2001234	104	0.366
cellular response to growth factor stimulus	GO:0071363	197	0.359	Mouse
neutrophil migration	GO:1990266	37	0.357	Mouse
response to growth factor	GO:0070848	198	0.355	Mouse
cytokine biosynthetic process	GO:0042089	68	0.346
t cell selection	GO:0045058	34	0.346
regulation of tumor necrosis factor production	GO:0032680	49	0.344
erk1 and erk2 cascade	GO:0070371	77	0.344	Mouse
negative regulation of innate immune response	GO:0045824	17	0.341
exocytosis	GO:0006887	121	0.339
positive regulation of cellular amino acid metabolic process	GO:0045764	3	0.338
regulation of leukocyte proliferation	GO:0070663	121	0.333
axonogenesis	GO:0007409	274	0.324	Fly
positive regulation of hematopoietic stem cell migration	GO:2000473	1	0.316
epithelial tube morphogenesis	GO:0060562	303	0.314
extrinsic apoptotic signaling pathway in absence of ligand	GO:0097192	55	0.312	Mouse
negative regulation of cell activation	GO:0050866	111	0.311
regulation of leukocyte differentiation	GO:1902105	159	0.311	Mouse
positive regulation of t cell proliferation	GO:0042102	52	0.309
regulation of rho protein signal transduction	GO:0035023	71	0.308	Mouse
cell adhesion	GO:0007155	329	0.305
t cell differentiation in thymus	GO:0033077	77	0.304
positive regulation of lymphocyte proliferation	GO:0050671	70	0.295
regulation of leukocyte apoptotic process	GO:2000106	56	0.291
neutrophil chemotaxis	GO:0030593	36	0.291	Mouse
single organism cell adhesion	GO:0098602	156	0.285
negative regulation of cell proliferation	GO:0008285	296	0.284
interferon gamma production	GO:0032609	67	0.284
ameboidal type cell migration	GO:0001667	128	0.279
cd8 positive alpha beta t cell extravasation	GO:0035697	3	0.275
regulation of monocyte extravasation	GO:2000437	2	0.274
myeloid leukocyte migration	GO:0097529	57	0.273	Mouse
neuron migration	GO:0001764	122	0.270	Mouse
negative regulation of cellular component organization	GO:0051129	194	0.270	Fly
regulation of extrinsic apoptotic signaling pathway	GO:2001236	77	0.269
eosinophil degranulation	GO:0043308	1	0.266
positive regulation of cell death	GO:0010942	224	0.265
gland development	GO:0048732	330	0.264	Fly
cytosolic calcium ion transport	GO:0060401	48	0.263
regulation of cd8 positive alpha beta t cell extravasation	GO:2000449	3	0.263
t cell extravasation	GO:0072683	4	0.260
regulation of antigen receptor mediated signaling pathway	GO:0050854	29	0.257
positive regulation of neutrophil chemotaxis	GO:0090023	12	0.256
negative regulation of growth	GO:0045926	99	0.253	Fly
stem cell differentiation	GO:0048863	268	0.252
regulation of immunological synapse formation	GO:2000520	2	0.251
regulation of neutrophil migration	GO:1902622	14	0.251
germ cell development	GO:0007281	185	0.249	Fly
negative regulation of defense response	GO:0031348	77	0.249
lymphocyte mediated immunity	GO:0002449	139	0.246
cell killing	GO:0001906	67	0.240
positive regulation of protein phosphorylation	GO:0001934	242	0.237
regulation of adaptive immune response based on somatic recombination of immune receptors built from immunoglobulin superfamily domains	GO:0002822	87	0.237
forebrain development	GO:0030900	302	0.237
positive regulation of chemotaxis	GO:0050921	38	0.237
positive regulation of t cell receptor signaling pathway	GO:0050862	4	0.232
single organismal cell cell adhesion	GO:0016337	131	0.230
negative regulation of eosinophil degranulation	GO:0043310	1	0.229
regulation of cell adhesion	GO:0030155	154	0.229
positive regulation of innate immune response	GO:0045089	80	0.229
leukocyte chemotaxis	GO:0030595	69	0.229	Mouse
regulation of apoptotic signaling pathway	GO:2001233	197	0.228
positive regulation of calcium mediated signaling	GO:0050850	15	0.226
lymphocyte proliferation	GO:0046651	164	0.226
regulation of inflammatory response	GO:0050727	147	0.221
negative regulation of cytokine production	GO:0001818	84	0.219
cellular amino acid metabolic process	GO:0006520	103	0.219
positive regulation of cell development	GO:0010720	237	0.218
regulation of response to wounding	GO:1903034	189	0.218
cellular response to lipopolysaccharide	GO:0071222	77	0.214
hematopoietic stem cell migration	GO:0035701	1	0.209
positive regulation of mapk cascade	GO:0043410	170	0.209
cell substrate adhesion	GO:0031589	130	0.208	Human Mouse
cytokine metabolic process	GO:0042107	71	0.207
regulation of homeostatic process	GO:0032844	182	0.205	Mouse
regulation of cell motility	GO:2000145	236	0.199	Mouse Fly
regulation of lymphocyte proliferation	GO:0050670	117	0.197
b cell activation involved in immune response	GO:0002312	50	0.195
digestive tract morphogenesis	GO:0048546	147	0.195
positive regulation of leukocyte differentiation	GO:1902107	86	0.194	Mouse
erythrocyte differentiation	GO:0030218	88	0.194
g protein coupled receptor signaling pathway	GO:0007186	243	0.192
regulation of hydrolase activity	GO:0051336	246	0.191
regulation of vesicle mediated transport	GO:0060627	139	0.189	Mouse
motor neuron axon guidance	GO:0008045	26	0.187
regulation of t cell extravasation	GO:2000407	3	0.187
positive regulation of leukocyte proliferation	GO:0070665	73	0.187
eosinophil activation	GO:0043307	1	0.185
dna metabolic process	GO:0006259	303	0.185
amine metabolic process	GO:0009308	45	0.184
muscle tissue development	GO:0060537	308	0.183	Mouse
homeostasis of number of cells	GO:0048872	210	0.180
positive regulation of dendritic cell chemotaxis	GO:2000510	1	0.180
positive regulation of transcription from rna polymerase ii promoter involved in smooth muscle cell differentiation	GO:2000721	2	0.180	Mouse
negative regulation of nervous system development	GO:0051961	156	0.178	Fly
t helper 1 type immune response	GO:0042088	25	0.178
chemokine mediated signaling pathway	GO:0070098	17	0.177
positive regulation of defense response	GO:0031349	124	0.177
small gtpase mediated signal transduction	GO:0007264	97	0.175	Mouse
cytokine secretion	GO:0050663	72	0.175
cellular ketone metabolic process	GO:0042180	84	0.175
regulation of alpha beta t cell proliferation	GO:0046640	18	0.174
positive t cell selection	GO:0043368	23	0.173
positive regulation of cell motility	GO:2000147	116	0.171	Mouse
defense response to virus	GO:0051607	68	0.170	Mouse
positive regulation of apoptotic process	GO:0043065	217	0.170
toll like receptor 7 signaling pathway	GO:0034154	4	0.170
regulation of cytokine secretion	GO:0050707	61	0.169
leukocyte apoptotic process	GO:0071887	71	0.169
innate immune response activating signal transduction	GO:0002758	50	0.168
regulation of mapk cascade	GO:0043408	248	0.166
positive regulation of immunological synapse formation	GO:2000522	1	0.164
regulation of erk1 and erk2 cascade	GO:0070372	71	0.163
signal transduction in absence of ligand	GO:0038034	55	0.163	Mouse
t helper 17 cell chemotaxis	GO:0035705	1	0.160
muscle cell differentiation	GO:0042692	261	0.159	Mouse
negative regulation of multi organism process	GO:0043901	68	0.158
helper t cell chemotaxis	GO:0035704	1	0.157
organelle localization	GO:0051640	179	0.156
interleukin 12 secretion	GO:0072610	3	0.156
regulation of protein kinase activity	GO:0045859	232	0.154
positive regulation of t cell costimulation	GO:2000525	2	0.152
regulation of protein localization	GO:0032880	231	0.151
wound healing	GO:0042060	157	0.151	Fly
regulation of t cell activation	GO:0050863	170	0.151
digestive system development	GO:0055123	200	0.150
response to lipopolysaccharide	GO:0032496	128	0.150
regulation of actin polymerization or depolymerization	GO:0008064	45	0.148
tissue remodeling	GO:0048771	102	0.147	Mouse
positive regulation of programmed cell death	GO:0043068	218	0.145
myeloid cell homeostasis	GO:0002262	114	0.144
tissue homeostasis	GO:0001894	115	0.144	Mouse
transmembrane receptor protein serine threonine kinase signaling pathway	GO:0007178	194	0.143	Mouse
positive regulation of nervous system development	GO:0051962	221	0.143
endocytosis	GO:0006897	168	0.143	Mouse Fly
activation of mapk activity	GO:0000187	59	0.142
regulation of lymphocyte mediated immunity	GO:0002706	84	0.141
positive regulation of interferon gamma production	GO:0032729	39	0.139
regulation of neutrophil chemotaxis	GO:0090022	14	0.138
regulation of myeloid cell differentiation	GO:0045637	96	0.137	Mouse
lymphocyte homeostasis	GO:0002260	64	0.135
negative regulation of homeostatic process	GO:0032845	71	0.132
regulation of hematopoietic stem cell migration	GO:2000471	1	0.131
cation homeostasis	GO:0055080	212	0.126
tumor necrosis factor production	GO:0032640	50	0.126
regulation of dendritic cell chemotaxis	GO:2000508	1	0.126
positive regulation of immune effector process	GO:0002699	107	0.123
phosphatidylinositol mediated signaling	GO:0048015	41	0.123
stem cell development	GO:0048864	219	0.122
gliogenesis	GO:0042063	141	0.121	Mouse
symbiosis encompassing mutualism through parasitism	GO:0044403	83	0.120
regulation of immune complex clearance by monocytes and macrophages	GO:0090264	2	0.120
keratinocyte differentiation	GO:0030216	48	0.120
extracellular structure organization	GO:0043062	148	0.120	Mouse
regulation of alpha beta t cell activation	GO:0046634	53	0.118
calcium ion transport into cytosol	GO:0060402	48	0.118
morphogenesis of a branching epithelium	GO:0061138	193	0.117
positive regulation of myeloid cell differentiation	GO:0045639	43	0.117	Mouse
cellular metal ion homeostasis	GO:0006875	151	0.117
tumor necrosis factor superfamily cytokine production	GO:0071706	51	0.115
microglial cell activation involved in immune response	GO:0002282	1	0.114
positive regulation of monocyte chemotaxis	GO:0090026	2	0.113
bone remodeling	GO:0046849	53	0.113	Mouse
regulation of dendritic cell apoptotic process	GO:2000668	3	0.112
guanosine containing compound metabolic process	GO:1901068	144	0.111
regulation of map kinase activity	GO:0043405	120	0.111
positive regulation of granulocyte chemotaxis	GO:0071624	12	0.111
alpha beta t cell proliferation	GO:0046633	21	0.110
regulation of tumor necrosis factor superfamily cytokine production	GO:1903555	50	0.109
negative regulation of ras protein signal transduction	GO:0046580	18	0.108	Mouse
regulation of protein secretion	GO:0050708	82	0.108
positive regulation of transferase activity	GO:0051347	167	0.108
interspecies interaction between organisms	GO:0044419	83	0.108
protein localization to organelle	GO:0033365	185	0.107
immunoglobulin mediated immune response	GO:0016064	69	0.106
regulation of t cell differentiation	GO:0045580	83	0.106
positive regulation of adaptive immune response	GO:0002821	61	0.106
odontogenesis of dentin containing tooth	GO:0042475	66	0.105	Mouse
positive regulation of t cell differentiation	GO:0045582	52	0.105
release of sequestered calcium ion into cytosol	GO:0051209	42	0.104
multicellular organismal homeostasis	GO:0048871	164	0.104	Mouse
regulation of actin cytoskeleton organization	GO:0032956	84	0.104
bone resorption	GO:0045453	38	0.104	Mouse
placenta development	GO:0001890	140	0.103	Mouse
activation of innate immune response	GO:0002218	56	0.103
telencephalon cell migration	GO:0022029	55	0.102
negative regulation of leukocyte mediated immunity	GO:0002704	29	0.102
b cell differentiation	GO:0030183	78	0.102
epithelial cell proliferation	GO:0050673	174	0.101
regulation of chemotaxis	GO:0050920	53	0.099
regulated secretory pathway	GO:0045055	32	0.099
peptidyl tyrosine phosphorylation	GO:0018108	143	0.098
regulation of toll like receptor signaling pathway	GO:0034121	20	0.096
gastrulation	GO:0007369	116	0.096
negative regulation of immune effector process	GO:0002698	55	0.096
positive regulation of alpha beta t cell activation	GO:0046635	39	0.095
immune complex clearance	GO:0002434	2	0.094
positive regulation of adaptive immune response based on somatic recombination of immune receptors built from immunoglobulin superfamily domains	GO:0002824	61	0.094
positive regulation of neutrophil migration	GO:1902624	12	0.094
natural killer cell activation	GO:0030101	44	0.094
interferon beta biosynthetic process	GO:0045350	4	0.093
multicellular organismal signaling	GO:0035637	91	0.093
establishment of organelle localization	GO:0051656	122	0.092
leukocyte degranulation	GO:0043299	27	0.092
somatic diversification of immune receptors via germline recombination within a single locus	GO:0002562	51	0.092
monocyte extravasation	GO:0035696	2	0.091
reactive nitrogen species metabolic process	GO:2001057	0	0.091
lymphocyte activation involved in immune response	GO:0002285	93	0.091	Human
regulation of eosinophil degranulation	GO:0043309	1	0.090
regulation of interleukin 6 production	GO:0032675	55	0.090
t cell activation involved in immune response	GO:0002286	43	0.088	Human
glial cell differentiation	GO:0010001	131	0.088	Mouse
blood coagulation	GO:0007596	76	0.086
carbohydrate derivative biosynthetic process	GO:1901137	183	0.086
positive regulation of apoptotic signaling pathway	GO:2001235	95	0.086
negative regulation of t cell activation	GO:0050868	65	0.085
cytoplasmic transport	GO:0016482	234	0.085
eosinophil activation involved in immune response	GO:0002278	1	0.085
alpha beta t cell differentiation involved in immune response	GO:0002293	30	0.084
regulation of vascular endothelial growth factor production	GO:0010574	13	0.083
immune complex clearance by monocytes and macrophages	GO:0002436	2	0.083
cell recognition	GO:0008037	83	0.083
phagocytosis	GO:0006909	66	0.082	Mouse Fly
tolerance induction	GO:0002507	14	0.082
somatic diversification of immunoglobulins	GO:0016445	43	0.081
negative regulation of toll like receptor signaling pathway	GO:0034122	14	0.081
post embryonic organ development	GO:0048569	17	0.080	Fly
interleukin 6 production	GO:0032635	58	0.080
isotype switching	GO:0045190	36	0.080
regulation of actin filament based process	GO:0032970	99	0.080
regulation of cellular component biogenesis	GO:0044087	181	0.079	Fly
regulation of t cell receptor signaling pathway	GO:0050856	21	0.079
morphogenesis of a branching structure	GO:0001763	203	0.079
cerebral cortex cell migration	GO:0021795	44	0.079
regulation of proteolysis	GO:0030162	164	0.079
transmembrane receptor protein tyrosine kinase signaling pathway	GO:0007169	247	0.079	Mouse
extracellular matrix organization	GO:0030198	147	0.078	Mouse
cellular lipid metabolic process	GO:0044255	323	0.078
somatic diversification of immunoglobulins involved in immune response	GO:0002208	36	0.078
inflammatory response to antigenic stimulus	GO:0002437	30	0.078
actin filament organization	GO:0007015	113	0.077
branching morphogenesis of an epithelial tube	GO:0048754	159	0.077
modulation of growth of symbiont involved in interaction with host	GO:0044144	19	0.077
cellular ion homeostasis	GO:0006873	165	0.077
regulation of ras protein signal transduction	GO:0046578	114	0.077	Mouse
cation transport	GO:0006812	399	0.076
positive regulation of behavior	GO:0048520	40	0.076
cellular response to lipid	GO:0071396	145	0.075
mesenchymal cell development	GO:0014031	93	0.075
leukocyte mediated cytotoxicity	GO:0001909	62	0.074
regulation of organelle organization	GO:0033043	289	0.074
cellular response to molecule of bacterial origin	GO:0071219	83	0.074
pallium development	GO:0021543	120	0.073
cellular response to external stimulus	GO:0071496	88	0.073	Mouse
cell junction organization	GO:0034330	77	0.073	Mouse
sequestering of calcium ion	GO:0051208	18	0.073
kidney development	GO:0001822	213	0.073	Mouse
regulation of establishment of protein localization	GO:0070201	181	0.072
regulation of inflammatory response to antigenic stimulus	GO:0002861	21	0.072
regulation of lymphocyte differentiation	GO:0045619	107	0.072
positive regulation of kinase activity	GO:0033674	155	0.072
negative regulation of type 2 immune response	GO:0002829	8	0.071
regulation of cell cycle	GO:0051726	281	0.071
negative regulation of intracellular signal transduction	GO:1902532	167	0.070	Mouse
glycoprotein biosynthetic process	GO:0009101	89	0.070
regulation of transferase activity	GO:0051338	263	0.069
regulation of cellular response to stress	GO:0080135	159	0.069
regulation of type 2 immune response	GO:0002828	18	0.069
sensory organ morphogenesis	GO:0090596	242	0.069	Mouse
regulation of peptidyl tyrosine phosphorylation	GO:0050730	93	0.069
regulation of cytoskeleton organization	GO:0051493	122	0.069
defense response to bacterium	GO:0042742	119	0.068
cerebral cortex development	GO:0021987	86	0.068
negative t cell selection	GO:0043383	13	0.068
protein secretion	GO:0009306	111	0.068
regulation of growth of symbiont in host	GO:0044126	19	0.068
endoderm development	GO:0007492	45	0.068
negative regulation of protein metabolic process	GO:0051248	282	0.068
synapse organization	GO:0050808	125	0.068	Fly
somatic recombination of immunoglobulin genes involved in immune response	GO:0002204	36	0.067
response to transforming growth factor beta	GO:0071559	88	0.067	Mouse
cardiac muscle tissue development	GO:0048738	130	0.067
eosinophil mediated immunity	GO:0002447	1	0.066
skeletal system development	GO:0001501	356	0.066
production of molecular mediator of immune response	GO:0002440	103	0.066
glycoprotein metabolic process	GO:0009100	116	0.065
microtubule based process	GO:0007017	236	0.065
negative regulation of growth of symbiont involved in interaction with host	GO:0044146	19	0.064
forebrain cell migration	GO:0021885	58	0.064
cognition	GO:0050890	149	0.064	Mouse
regulation of mast cell proliferation	GO:0070666	4	0.064
regulation of metal ion transport	GO:0010959	106	0.063
microglial cell activation	GO:0001774	3	0.063
t cell mediated immunity	GO:0002456	50	0.063
maintenance of location	GO:0051235	89	0.063
cytosolic calcium ion homeostasis	GO:0051480	70	0.063
divalent metal ion transport	GO:0070838	172	0.062
regulation of angiogenesis	GO:0045765	81	0.062
thymic t cell selection	GO:0045061	22	0.062
mesodermal cell migration	GO:0008078	4	0.062
cellular protein complex assembly	GO:0043623	116	0.062
cell growth	GO:0016049	130	0.061	Fly
regulation of anatomical structure size	GO:0090066	178	0.060
salivary gland development	GO:0007431	37	0.060	Fly
neural precursor cell proliferation	GO:0061351	121	0.060
cellular chemical homeostasis	GO:0055082	215	0.060
cell maturation	GO:0048469	127	0.060
protein catabolic process	GO:0030163	221	0.060
negative regulation of rho protein signal transduction	GO:0035024	7	0.060	Mouse
intracellular receptor signaling pathway	GO:0030522	74	0.059
positive regulation of map kinase activity	GO:0043406	84	0.059
posttranscriptional regulation of gene expression	GO:0010608	155	0.058
dna recombination	GO:0006310	92	0.058
regulation of t helper 1 type immune response	GO:0002825	17	0.058
microglia differentiation	GO:0014004	2	0.058	Mouse
positive regulation of erk1 and erk2 cascade	GO:0070374	47	0.057
natural killer cell mediated immunity	GO:0002228	29	0.057
regulation of endopeptidase activity	GO:0052548	89	0.057
interleukin 12 production	GO:0032615	32	0.057
negative regulation of erk1 and erk2 cascade	GO:0070373	21	0.057
regulation of tumor necrosis factor biosynthetic process	GO:0042534	10	0.057
positive regulation of cytosolic calcium ion concentration	GO:0007204	65	0.056
positive regulation of peptidyl tyrosine phosphorylation	GO:0050731	61	0.056
divalent inorganic cation transport	GO:0072511	178	0.056
segmentation	GO:0035282	93	0.056
regulation of exocytosis	GO:0017157	61	0.055
b cell mediated immunity	GO:0019724	71	0.055
regulation of cellular component size	GO:0032535	121	0.055
cellular calcium ion homeostasis	GO:0006874	119	0.055
positive regulation of stress activated mapk cascade	GO:0032874	48	0.055
positive regulation of organelle organization	GO:0010638	128	0.055
substrate adhesion dependent cell spreading	GO:0034446	30	0.054
alpha beta t cell activation involved in immune response	GO:0002287	31	0.054
establishment or maintenance of cell polarity	GO:0007163	86	0.054
interleukin 1 beta production	GO:0032611	30	0.054
positive regulation of myeloid leukocyte differentiation	GO:0002763	26	0.054	Mouse
protein localization to nucleus	GO:0034504	121	0.054
regulation of leukocyte mediated cytotoxicity	GO:0001910	38	0.053
actin polymerization or depolymerization	GO:0008154	54	0.053
neutrophil mediated killing of gram positive bacterium	GO:0070946	2	0.053
regulation of erythrocyte differentiation	GO:0045646	23	0.053
positive regulation of antigen receptor mediated signaling pathway	GO:0050857	9	0.052
lipopolysaccharide mediated signaling pathway	GO:0031663	25	0.052
blood circulation	GO:0008015	195	0.052
positive regulation of leukocyte mediated immunity	GO:0002705	70	0.052
calcium mediated signaling	GO:0019722	46	0.052
interleukin 2 production	GO:0032623	33	0.051
positive regulation of leukocyte mediated cytotoxicity	GO:0001912	31	0.051
sequestering of metal ion	GO:0051238	19	0.051
regulation of endocytosis	GO:0030100	69	0.051	Mouse
female gamete generation	GO:0007292	74	0.051	Fly
positive regulation of osteoblast proliferation	GO:0033690	9	0.051	Mouse
regulation of multi organism process	GO:0043900	111	0.050
t cell apoptotic process	GO:0070231	39	0.050
i kappab kinase nf kappab signaling	GO:0007249	85	0.050
regulation of protein transport	GO:0051223	163	0.050
positive regulation of protein kinase activity	GO:0045860	144	0.050
toll like receptor signaling pathway	GO:0002224	38	0.049
negative regulation of response to wounding	GO:1903035	77	0.049
regulation of cell killing	GO:0031341	40	0.049
regulation of ion homeostasis	GO:2000021	64	0.049
negative regulation of lymphocyte activation	GO:0051250	91	0.048
urogenital system development	GO:0001655	261	0.048	Mouse
negative regulation of leukocyte differentiation	GO:1902106	51	0.048
positive regulation of glycoprotein biosynthetic process involved in immunological synapse formation	GO:2000526	1	0.048
positive regulation of cell adhesion	GO:0045785	80	0.048
positive regulation of cysteine type endopeptidase activity involved in apoptotic process	GO:0043280	36	0.048
mesenchyme development	GO:0060485	152	0.048
somatic diversification of immune receptors	GO:0002200	53	0.047
mammary gland epithelium development	GO:0061180	65	0.047
protein kinase b signaling	GO:0043491	74	0.047
endomembrane system organization	GO:0010256	147	0.047
smooth muscle tissue development	GO:0048745	22	0.047	Mouse
regulation of epithelial cell proliferation	GO:0050678	141	0.047
regulation of transmembrane receptor protein serine threonine kinase signaling pathway	GO:0090092	112	0.046	Mouse
regulation of protein complex assembly	GO:0043254	83	0.046
antigen processing and presentation	GO:0019882	47	0.046
regulation of calcium mediated signaling	GO:0050848	19	0.046
heterocycle catabolic process	GO:0046700	280	0.046
reactive oxygen species biosynthetic process	GO:1903409	8	0.046
embryonic organ morphogenesis	GO:0048562	276	0.045	Mouse
negative regulation of macrophage apoptotic process	GO:2000110	3	0.045
somatic recombination of immunoglobulin gene segments	GO:0016447	42	0.045
positive regulation of inflammatory response to antigenic stimulus	GO:0002863	11	0.045
myeloid dendritic cell differentiation	GO:0043011	16	0.045
acute inflammatory response	GO:0002526	41	0.045
regulation of membrane potential	GO:0042391	192	0.045
regulation of cysteine type endopeptidase activity involved in apoptotic process	GO:0043281	62	0.045
negative regulation of phosphorylation	GO:0042326	166	0.045
t cell differentiation involved in immune response	GO:0002292	30	0.044
circulatory system process	GO:0003013	197	0.044
production of molecular mediator involved in inflammatory response	GO:0002532	21	0.044
stress activated mapk cascade	GO:0051403	80	0.044
positive regulation of b cell activation	GO:0050871	49	0.043
somatic cell dna recombination	GO:0016444	51	0.043
regulation of homotypic cell cell adhesion	GO:0034110	13	0.043
plasma membrane organization	GO:0007009	90	0.043
epithelial cell development	GO:0002064	159	0.043
growth of symbiont in host	GO:0044117	23	0.043
cd4 positive alpha beta t cell differentiation	GO:0043367	41	0.043
notch signaling pathway	GO:0007219	71	0.043
cell adhesion mediated by integrin	GO:0033627	18	0.043	Mouse

Itgal disease predictions

Disease predictions are made from cross-annotation of human disease genes to the identified functional analogs in mouse and predicted with the mouse functional network.

	Disease	DO term ID	Size	Probability	Func Analog Org
	immune system disease	DOID:2914	0	0.066
	disease of anatomical entity	DOID:7	0	0.066

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