Mus musculus

138 known processes

Sh2d1b1

SH2 domain protein 1B1

(Aliases: Sh2d1b,Eat2a,EAT-2,Eat2,EAT-2A)

Sh2d1b1 biological process predictions


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Biological processGO term IDProcess sizeProbabilityFunc Analog Org
regulation of natural killer cell activationGO:0032814220.910
Mouse
natural killer cell activationGO:0030101440.761
Mouse
organelle fusionGO:0048284280.572
membrane fusionGO:0061025380.428
immune effector processGO:00022523210.398
vesicle fusionGO:0006906160.380
regulation of vesicle fusionGO:003133860.275
natural killer cell inhibitory signaling pathwayGO:000276920.251
regulation of vesicle mediated transportGO:00606271390.214
leukocyte mediated cytotoxicityGO:0001909620.189
vesicle organizationGO:0016050600.167
leukocyte activation involved in immune responseGO:00023661260.161
regulation of leukocyte mediated cytotoxicityGO:0001910380.160
membrane organizationGO:00610242450.157
innate immune responseGO:00450871570.149
cell killingGO:0001906670.129
positive regulation of natural killer cell mediated immunityGO:0002717160.128
regulation of cell activationGO:00508652890.127
Mouse
regulation of defense responseGO:00313472330.121
cellular amine metabolic processGO:0044106440.119
cytokine productionGO:00018163190.117
regulation of organelle organizationGO:00330432890.109
positive regulation of cell killingGO:0031343330.102
regulation of leukocyte mediated immunityGO:00027031040.101
leukocyte mediated immunityGO:00024431740.099
positive regulation of defense responseGO:00313491240.089
cell activation involved in immune responseGO:00022631260.084
immune response regulating signaling pathwayGO:00027641250.077
regulation of reactive oxygen species metabolic processGO:2000377400.076
t cell activationGO:00421102890.074
g protein coupled receptor signaling pathwayGO:00071862430.073
regulation of innate immune responseGO:0045088910.072
negative regulation of intracellular signal transductionGO:19025321670.072
cation homeostasisGO:00550802120.070
defense response to bacteriumGO:00427421190.067
immune response inhibiting signal transductionGO:000276540.067
reactive oxygen species metabolic processGO:0072593840.066
regulation of cytokine productionGO:00018172660.065
immune response activating signal transductionGO:00027571160.065
cellular response to biotic stimulusGO:0071216920.062
immune response regulating cell surface receptor signaling pathwayGO:0002768800.060
stimulatory c type lectin receptor signaling pathwayGO:000222320.060
positive regulation of cytokine productionGO:00018191740.060
chemotaxisGO:00069352470.059
amine metabolic processGO:0009308450.059
leukocyte chemotaxisGO:0030595690.058
regulation of cellular amine metabolic processGO:0033238200.057
regulation of ion transportGO:00432692150.055
regulation of cellular ketone metabolic processGO:0010565660.054
blood circulationGO:00080151950.054
regulation of lymphocyte activationGO:00512492400.053
Mouse
cell surface pattern recognition receptor signaling pathwayGO:000275220.052
natural killer cell mediated cytotoxicityGO:0042267290.051
negative regulation of cellular protein metabolic processGO:00322692470.051
negative regulation of phosphorylationGO:00423261660.050
negative regulation of cellular amino acid metabolic processGO:004576300.049
regulation of natural killer cell mediated immunityGO:0002715190.049
defense response to other organismGO:00985421970.047
immune response activating cell surface receptor signaling pathwayGO:0002429720.047
positive regulation of immune effector processGO:00026991070.047
reactive nitrogen species metabolic processGO:200105700.046
placenta developmentGO:00018901400.046
myeloid cell differentiationGO:00300992330.046
adaptive immune response based on somatic recombination of immune receptors built from immunoglobulin superfamily domainsGO:00024601450.046
leukocyte migrationGO:00509001240.046
regulation of system processGO:00440572000.046
reactive oxygen species biosynthetic processGO:190340980.045
cellular lipid metabolic processGO:00442553230.045
cell chemotaxisGO:0060326810.044
negative regulation of protein phosphorylationGO:00019331260.043
regulation of phospholipase c activityGO:190027430.043
positive regulation of cellular amine metabolic processGO:003324050.042
positive regulation of innate immune responseGO:0045089800.042
transmembrane transportGO:00550854120.040
negative regulation of phosphate metabolic processGO:00459361840.039
response to molecule of bacterial originGO:00022371430.039
cellular response to molecule of bacterial originGO:0071219830.039
apoptotic signaling pathwayGO:00971903060.037
metal ion homeostasisGO:00550651890.037
negative regulation of protein metabolic processGO:00512482820.036
cellular calcium ion homeostasisGO:00068741190.036
immune response inhibiting cell surface receptor signaling pathwayGO:000276730.036
inflammatory responseGO:00069542440.036
osteoclast differentiationGO:0030316620.035
homeostasis of number of cellsGO:00488722100.035
response to molecule of fungal originGO:000223840.035
extrinsic apoptotic signaling pathway in absence of ligandGO:0097192550.035
regulation of erk1 and erk2 cascadeGO:0070372710.035
myeloid leukocyte mediated immunityGO:0002444420.035
extrinsic apoptotic signaling pathwayGO:00971911260.034
calcium mediated signalingGO:0019722460.034
positive regulation of leukocyte mediated cytotoxicityGO:0001912310.033
cellular metal ion homeostasisGO:00068751510.033
sequestering of calcium ionGO:0051208180.033
signal transduction in absence of ligandGO:0038034550.033
lymphocyte differentiationGO:00300982420.033
branching morphogenesis of an epithelial tubeGO:00487541590.032
positive regulation of secretion by cellGO:19035321140.031
carbohydrate metabolic processGO:00059752300.031
cellular response to acid chemicalGO:0071229680.031
regulation of reactive oxygen species biosynthetic processGO:190342620.031
mapk cascadeGO:00001652810.031
macromolecule catabolic processGO:00090572810.030
negative regulation of phosphorus metabolic processGO:00105631840.030
myeloid leukocyte differentiationGO:00025731190.030
positive regulation of protein modification processGO:00314012990.030
regulation of mapk cascadeGO:00434082480.030
positive regulation of reactive oxygen species biosynthetic processGO:190342820.029
purine containing compound metabolic processGO:00725213110.029
positive regulation of reactive oxygen species metabolic processGO:2000379110.029
male gamete generationGO:00482322850.029
acute inflammatory responseGO:0002526410.028
neutrophil mediated killing of gram positive bacteriumGO:007094620.028
positive regulation of cd8 positive alpha beta t cell extravasationGO:200045120.028
positive regulation of response to woundingGO:1903036660.028
multi multicellular organism processGO:00447061090.027
antigen receptor mediated signaling pathwayGO:0050851640.027
regulation of mast cell activationGO:0033003210.027
response to drugGO:0042493750.027
peptidyl amino acid modificationGO:00181933360.026
tissue homeostasisGO:00018941150.026
cellular response to lipidGO:00713961450.026
b cell activationGO:00421131610.026
positive regulation of cell developmentGO:00107202370.026
regulation of cell migrationGO:00303342190.026
chromatin organizationGO:00063252060.026
oxidation reduction processGO:00551143420.026
negative regulation of immune effector processGO:0002698550.025
phagocytosisGO:0006909660.025
natural killer cell mediated immunityGO:0002228290.025
regulation of apoptotic signaling pathwayGO:20012331970.025
interferon gamma productionGO:0032609670.025
leukocyte proliferationGO:00706611720.024
positive regulation of angiogenesisGO:0045766460.024
divalent inorganic cation transportGO:00725111780.024
pattern recognition receptor signaling pathwayGO:0002221470.024
positive regulation of t cell receptor signaling pathwayGO:005086240.024
innate immune response activating cell surface receptor signaling pathwayGO:000222040.024
response to lipopolysaccharideGO:00324961280.024
cellular response to lipopolysaccharideGO:0071222770.023
purine ribonucleotide metabolic processGO:00091502900.023
circulatory system processGO:00030131970.023
multicellular organismal homeostasisGO:00488711640.023
sensory perceptionGO:00076002450.023
germ cell developmentGO:00072811850.023
positive regulation of cell activationGO:00508671580.023
negative regulation of cellular amine metabolic processGO:003323910.023
tissue remodelingGO:00487711020.023
regulation of calcium mediated signalingGO:0050848190.022
sequestering of metal ionGO:0051238190.022
morphogenesis of a branching structureGO:00017632030.022
humoral immune responseGO:0006959570.022
Mouse
cellular ketone metabolic processGO:0042180840.022
nitrogen compound transportGO:00717052710.022
positive regulation of natural killer cell mediated cytotoxicityGO:0045954160.022
cytosolic calcium ion homeostasisGO:0051480700.022
glycoprotein metabolic processGO:00091001160.022
erk1 and erk2 cascadeGO:0070371770.022
positive regulation of phospholipase c activityGO:001086320.022
regulation of homeostatic processGO:00328441820.022
positive regulation of dendritic cell chemotaxisGO:200051010.021
regulation of intracellular transportGO:00323861590.021
b cell differentiationGO:0030183780.021
negative regulation of cell activationGO:00508661110.021
regulation of secretionGO:00510462740.021
positive regulation of tumor necrosis factor productionGO:0032760300.021
monocyte extravasationGO:003569620.020
regulation of cellular amino acid metabolic processGO:000652150.020
response to acid chemicalGO:00011011110.020
muscle tissue developmentGO:00605373080.020
ameboidal type cell migrationGO:00016671280.020
organonitrogen compound catabolic processGO:19015652640.020
neutrophil mediated immunityGO:0002446190.020
regulation of body fluid levelsGO:00508781620.020
regulation of cell killingGO:0031341400.020
negative regulation of apoptotic signaling pathwayGO:20012341040.020
skeletal muscle organ developmentGO:00605381630.020
anion transportGO:00068201770.020
peptidyl tyrosine phosphorylationGO:00181081430.020
urogenital system developmentGO:00016552610.019
compound eye developmentGO:004874910.019
regulation of b cell activationGO:0050864810.019
regulation of angiotensin metabolic processGO:006017740.019
positive regulation of erk1 and erk2 cascadeGO:0070374470.019
neutrophil migrationGO:1990266370.019
ossificationGO:00015032160.019
fat cell differentiationGO:00454441600.019
spermatogenesisGO:00072832840.019
monocarboxylic acid metabolic processGO:00327871910.019
regulation of protein transportGO:00512231630.019
vascular process in circulatory systemGO:0003018620.019
cellular chemical homeostasisGO:00550822150.018
negative regulation of cell proliferationGO:00082852960.018
regulation of tumor necrosis factor superfamily cytokine productionGO:1903555500.018
regulation of leukocyte differentiationGO:19021051590.018
regulation of hydrolase activityGO:00513362460.018
positive regulation of neuron differentiationGO:00456661410.018
carbohydrate derivative biosynthetic processGO:19011371830.018
cellular response to molecule of fungal originGO:007122620.018
ion transmembrane transportGO:00342203610.018
innate immune response activating signal transductionGO:0002758500.018
regulation of osteoclast differentiationGO:0045670360.018
regulation of metal ion transportGO:00109591060.018
forebrain developmentGO:00309003020.018
regulation of peptidase activityGO:0052547960.018
transmembrane receptor protein tyrosine kinase signaling pathwayGO:00071692470.017
cytoplasmic transportGO:00164822340.017
nucleoside metabolic processGO:00091162460.017
cytokine mediated signaling pathwayGO:00192211150.017
positive regulation of chemotaxisGO:0050921380.017
transmission of nerve impulseGO:0019226760.017
axonogenesisGO:00074092740.017
regulation of extrinsic apoptotic signaling pathwayGO:2001236770.017
t cell receptor signaling pathwayGO:0050852460.017
regulation of tissue remodelingGO:0034103380.017
regulation of vasculature developmentGO:1901342880.017
positive regulation of phospholipase activityGO:001051830.017
regulation of synaptic growth at neuromuscular junctionGO:000858240.017
positive regulation of acute inflammatory responseGO:0002675160.016
regulation of t cell activationGO:00508631700.016
antigen processing and presentationGO:0019882470.016
positive regulation of cellular amino acid metabolic processGO:004576430.016
tumor necrosis factor productionGO:0032640500.016
myeloid leukocyte activationGO:0002274830.016
epithelial tube morphogenesisGO:00605623030.016
nucleoside phosphate metabolic processGO:00067533380.016
regulation of cytokine secretionGO:0050707610.016
divalent metal ion transportGO:00708381720.016
camera type eye developmentGO:00430102660.016
regulation of hormone levelsGO:00108172110.016
response to oxygen levelsGO:0070482620.016
positive regulation of transcription from rna polymerase ii promoter involved in smooth muscle cell differentiationGO:200072120.016
regulation of blood pressureGO:0008217930.016
regulation of t cell extravasationGO:200040730.016
ribose phosphate metabolic processGO:00196932910.016
detection of yeastGO:000187920.016
cell recognitionGO:0008037830.016
tumor necrosis factor superfamily cytokine productionGO:0071706510.016
regulation of systemic arterial blood pressure by hormoneGO:0001990250.016
synaptic transmissionGO:00072683290.016
cellular response to dna damage stimulusGO:00069742070.016
protein glycosylationGO:0006486550.016
positive regulation of leukocyte differentiationGO:1902107860.015
response to decreased oxygen levelsGO:0036293590.015
striated muscle tissue developmentGO:00147062930.015
positive regulation of nervous system developmentGO:00519622210.015
protein secretionGO:00093061110.015
cell growthGO:00160491300.015
positive regulation of inflammatory responseGO:0050729470.015
positive regulation of lymphocyte activationGO:00512511400.015
regulation of epithelial cell proliferationGO:00506781410.015
fatty acid metabolic processGO:00066311210.015
positive regulation of mapk cascadeGO:00434101700.015
regulation of proteolysisGO:00301621640.015
negative regulation of leukocyte mediated immunityGO:0002704290.015
organophosphate biosynthetic processGO:00904071220.015
organic cyclic compound catabolic processGO:19013612950.015
t helper 17 cell chemotaxisGO:003570510.015
regulation of ossificationGO:00302781120.015
protein catabolic processGO:00301632210.015
regulation of secretion by cellGO:19035302490.015
regulation of hematopoietic stem cell migrationGO:200047110.015
posttranscriptional regulation of gene expressionGO:00106081550.015
ribonucleoside metabolic processGO:00091192450.014
maintenance of locationGO:0051235890.014
macromolecule glycosylationGO:0043413550.014
regulation of leukocyte apoptotic processGO:2000106560.014
regulation of cell motilityGO:20001452360.014
second messenger mediated signalingGO:0019932730.014
regulation of protein secretionGO:0050708820.014
cellular response to external stimulusGO:0071496880.014
eosinophil activationGO:004330710.014
nucleobase containing small molecule metabolic processGO:00550863520.014
b cell mediated immunityGO:0019724710.014
ras protein signal transductionGO:0007265770.014
regulation of myeloid cell differentiationGO:0045637960.014
lipid biosynthetic processGO:00086101790.014
sphingolipid metabolic processGO:0006665450.014
dna metabolic processGO:00062593030.014
regulation of adaptive immune response based on somatic recombination of immune receptors built from immunoglobulin superfamily domainsGO:0002822870.014
blood vessel morphogenesisGO:00485142850.014
g protein coupled receptor signaling pathway coupled to cyclic nucleotide second messengerGO:0007187550.014
organonitrogen compound biosynthetic processGO:19015661920.014
regulation of tube sizeGO:0035150570.014
neutrophil chemotaxisGO:0030593360.014
production of molecular mediator of immune responseGO:00024401030.014
t cell differentiationGO:00302171740.014
positive regulation of t cell extravasationGO:200040920.014
stem cell developmentGO:00488642190.013
positive regulation of peptidyl tyrosine phosphorylationGO:0050731610.013
regulation of lipase activityGO:0060191150.013
gland developmentGO:00487323300.013
negative regulation of cellular component organizationGO:00511291940.013
response to inorganic substanceGO:0010035960.013
regulation of transmembrane transportGO:00347621280.013
purine ribonucleoside metabolic processGO:00461282410.013
ear developmentGO:00435832000.013
morphogenesis of an epithelial sheetGO:0002011270.013
carbohydrate derivative catabolic processGO:19011362310.013
regulation of kinase activityGO:00435492490.013
regulation of antigen receptor mediated signaling pathwayGO:0050854290.013
regulation of anatomical structure sizeGO:00900661780.013
regulation of cellular response to oxidative stressGO:1900407190.013
ribonucleotide metabolic processGO:00092592910.013
nuclear divisionGO:00002801580.013
microglia developmentGO:001400520.013
regulation of interferon gamma productionGO:0032649570.013
negative regulation of growthGO:0045926990.013
positive regulation of cell motilityGO:20001471160.013
neuron apoptotic processGO:00514021420.013
defense response to gram positive bacteriumGO:0050830500.013
cell junction organizationGO:0034330770.013
epithelial cell migrationGO:0010631630.013
wound healingGO:00420601570.013
methylationGO:00322591340.013
microglia differentiationGO:001400420.013
regulation of transferase activityGO:00513382630.012
regulation of ion transmembrane transportGO:00347651190.012
cellular extravasationGO:0045123170.012
positive regulation of ion transportGO:0043270650.012
calcium ion homeostasisGO:00550741270.012
organic anion transportGO:00157111370.012
cd4 positive alpha beta t cell activationGO:0035710450.012
anatomical structure homeostasisGO:00602491450.012
neuron migrationGO:00017641220.012
glycoprotein biosynthetic processGO:0009101890.012
regulation of exocytosisGO:0017157610.012
transmembrane receptor protein serine threonine kinase signaling pathwayGO:00071781940.012
granulocyte migrationGO:0097530430.012
protein processingGO:00164851630.012
small gtpase mediated signal transductionGO:0007264970.012
regulation of calcium ion transportGO:0051924690.012
nucleotide metabolic processGO:00091173320.012
positive regulation of glycoprotein biosynthetic process involved in immunological synapse formationGO:200052610.012
negative regulation of synapse assemblyGO:005196430.012
organic hydroxy compound metabolic processGO:19016152030.012
platelet morphogenesisGO:0036344130.012
regulation of systemic arterial blood pressure mediated by a chemical signalGO:0003044330.012
detection of stimulusGO:0051606840.012
disruption by host of symbiont cellsGO:0051852110.012
response to oxidative stressGO:00069791230.012
positive regulation of lymphocyte proliferationGO:0050671700.012
purine nucleotide metabolic processGO:00061633020.012
cellular response to organonitrogen compoundGO:00714171450.012
negative regulation of molecular functionGO:00440922580.012
tissue migrationGO:0090130680.012
lymphocyte mediated immunityGO:00024491390.012
organelle localizationGO:00516401790.012
positive regulation of tumor necrosis factor superfamily cytokine productionGO:1903557310.012
multicellular organismal signalingGO:0035637910.011
cellular response to oxidative stressGO:0034599760.011
cellular nitrogen compound catabolic processGO:00442702800.011
response to organonitrogen compoundGO:00102432460.011
activation of innate immune responseGO:0002218560.011
disruption of cells of other organism involved in symbiotic interactionGO:0051818130.011
negative regulation of secretionGO:0051048610.011
regulation of interleukin 10 secretionGO:200117940.011
cellular divalent inorganic cation homeostasisGO:00725031270.011
regulation of neuron differentiationGO:00456642810.011
divalent inorganic cation homeostasisGO:00725071380.011
muscle cell differentiationGO:00426922610.011
killing of cells in other organism involved in symbiotic interactionGO:0051883130.011
regulation of lymphocyte mediated immunityGO:0002706840.011
camp metabolic processGO:0046058400.011
regulation of cellular component biogenesisGO:00440871810.011
positive regulation of glutamate secretionGO:001404920.011
defense response to gram negative bacteriumGO:0050829280.011
myeloid leukocyte migrationGO:0097529570.011
regulation of chemokine productionGO:0032642300.011
response to nutrient levelsGO:00316671090.011
regulation of angiotensin levels in bloodGO:000200240.011
regulation of phagocytosisGO:0050764330.011
cellular homeostasisGO:00197252400.011
positive regulation of t cell activationGO:00508701010.011
phospholipase c activating g protein coupled receptor signaling pathwayGO:0007200260.011
multi organism behaviorGO:0051705620.011
organ regenerationGO:003110020.011
exocytosisGO:00068871210.011
positive regulation of phagocytosisGO:0050766260.011
negative regulation of extrinsic apoptotic signaling pathwayGO:2001237450.011
regulation of lymphocyte proliferationGO:00506701170.011
positive regulation of immunological synapse formationGO:200052210.011
response to transforming growth factor betaGO:0071559880.011
cd8 positive alpha beta t cell extravasationGO:003569730.011
dephosphorylationGO:00163111290.011
response to peptide hormoneGO:00434341270.010
b cell proliferationGO:0042100530.010
regulation of action potentialGO:009890040.010
regulation of systemic arterial blood pressureGO:0003073610.010
regulation of b cell proliferationGO:0030888390.010
regulated secretory pathwayGO:0045055320.010
keratinocyte migrationGO:005154630.010
regulation of t cell costimulationGO:200052320.010
platelet derived growth factor receptor signaling pathwayGO:0048008320.010
glycerolipid metabolic processGO:00464861220.010
lymphocyte activation involved in immune responseGO:0002285930.010
positive regulation of cytokine biosynthetic processGO:0042108400.010
epithelial cell proliferationGO:00506731740.010
negative regulation of cell migrationGO:0030336590.010
bone mineralizationGO:0030282540.010
steroid metabolic processGO:00082021190.010
positive regulation of hematopoietic stem cell migrationGO:200047310.010
regulation of cell cycleGO:00517262810.010
chloride transportGO:0006821320.010
positive regulation of cell deathGO:00109422240.010
transforming growth factor beta receptor signaling pathwayGO:0007179710.010
dna repairGO:00062811070.010

Sh2d1b1 disease predictions

Disease predictions are made from cross-annotation of human disease genes to the identified functional analogs in mouse and predicted with the mouse functional network.

DiseaseDO term IDSizeProbabilityFunc Analog Org
disease of anatomical entityDOID:700.075
musculoskeletal system diseaseDOID:1700.075
connective tissue diseaseDOID:6500.075
bone diseaseDOID:008000100.072
disease of metabolismDOID:001466700.022
nervous system diseaseDOID:86300.020
central nervous system diseaseDOID:33100.015
sensory system diseaseDOID:005015500.011
organ system cancerDOID:005068600.011
disease of cellular proliferationDOID:1456600.011
cancerDOID:16200.011