Mus musculus

122 known processes

Pcsk9

proprotein convertase subtilisin/kexin type 9

(Aliases: PC9,AI747682,MGC47409,HCHOLA3,Narc1,FH3,AI415265)

Pcsk9 biological process predictions


Filter by process size:
Biological processGO term IDProcess sizeProbabilityFunc Analog Org
transmembrane transportGO:00550854120.114
amine metabolic processGO:0009308450.099
ion transmembrane transportGO:00342203610.093
cellular amino acid metabolic processGO:00065201030.086
cellular ketone metabolic processGO:0042180840.078
regulation of cellular amine metabolic processGO:0033238200.078
apoptotic signaling pathwayGO:00971903060.076
regulation of cellular amino acid metabolic processGO:000652150.074
skeletal system developmentGO:00015013560.071
cellular amine metabolic processGO:0044106440.070
small molecule biosynthetic processGO:00442831320.066
organic hydroxy compound metabolic processGO:19016152030.064
regulation of cellular ketone metabolic processGO:0010565660.063
cation transportGO:00068123990.057
regulation of secretionGO:00510462740.057
sensory perceptionGO:00076002450.055
developmental maturationGO:00217001930.052
ribonucleotide metabolic processGO:00092592910.051
purine ribonucleotide metabolic processGO:00091502900.051
purine containing compound metabolic processGO:00725213110.049
regulation of membrane potentialGO:00423911920.048
purine nucleotide metabolic processGO:00061633020.046
cation homeostasisGO:00550802120.046
regulation of homeostatic processGO:00328441820.046
ras protein signal transductionGO:0007265770.045
oxidation reduction processGO:00551143420.045
nitrogen compound transportGO:00717052710.044
regulation of protein localizationGO:00328802310.043
embryonic organ morphogenesisGO:00485622760.043
cellular chemical homeostasisGO:00550822150.042
nucleoside phosphate metabolic processGO:00067533380.041
nucleobase containing small molecule metabolic processGO:00550863520.041
sensory organ morphogenesisGO:00905962420.040
male gamete generationGO:00482322850.040
cellular homeostasisGO:00197252400.040
anion transportGO:00068201770.040
steroid metabolic processGO:00082021190.040
gland developmentGO:00487323300.040
ossificationGO:00015032160.039
skin developmentGO:00435882200.039
synaptic transmissionGO:00072683290.039
cholesterol metabolic processGO:0008203560.039
ribose phosphate metabolic processGO:00196932910.038
cation transmembrane transportGO:00986552660.038
ribonucleoside metabolic processGO:00091192450.038
metal ion homeostasisGO:00550651890.038
organic cyclic compound catabolic processGO:19013612950.037
regulation of secretion by cellGO:19035302490.037
cellular lipid metabolic processGO:00442553230.037
forebrain developmentGO:00309003020.036
regulation of transmembrane receptor protein serine threonine kinase signaling pathwayGO:00900921120.036
regulation of cell cycleGO:00517262810.036
positive regulation of cellular amine metabolic processGO:003324050.036
regulation of mapk cascadeGO:00434082480.035
locomotory behaviorGO:00076261950.035
nucleotide metabolic processGO:00091173320.035
negative regulation of protein metabolic processGO:00512482820.035
heterocycle catabolic processGO:00467002800.035
hematopoietic progenitor cell differentiationGO:00022441430.035
cell adhesionGO:00071553290.035
regulation of cell morphogenesis involved in differentiationGO:00107691510.035
positive regulation of cellular amino acid metabolic processGO:004576430.034
cell type specific apoptotic processGO:00972852680.034
regulation of body fluid levelsGO:00508781620.034
regulation of system processGO:00440572000.034
response to organic cyclic compoundGO:00140701980.034
cellular response to lipidGO:00713961450.034
regionalizationGO:00030023370.034
ribonucleoside triphosphate metabolic processGO:00091992200.034
cellular ion homeostasisGO:00068731650.034
calcium ion homeostasisGO:00550741270.033
connective tissue developmentGO:00614481790.033
epidermis developmentGO:00085441870.033
transmembrane receptor protein serine threonine kinase signaling pathwayGO:00071781940.033
renal system developmentGO:00720012250.033
cellular metal ion homeostasisGO:00068751510.033
peptidyl amino acid modificationGO:00181933360.033
regulation of nucleotide metabolic processGO:00061401690.032
bone developmentGO:00603481200.032
lipid biosynthetic processGO:00086101790.032
epithelial cell developmentGO:00020641590.031
action potentialGO:0001508780.031
spermatogenesisGO:00072832840.031
camera type eye developmentGO:00430102660.031
kidney developmentGO:00018222130.031
negative regulation of cellular amino acid metabolic processGO:004576300.031
regulation of organ morphogenesisGO:20000271440.031
cytokine productionGO:00018163190.031
sterol metabolic processGO:0016125580.031
homeostasis of number of cellsGO:00488722100.031
neuronal action potentialGO:0019228540.031
nucleoside triphosphate catabolic processGO:00091432050.030
cellular divalent inorganic cation homeostasisGO:00725031270.030
b cell activationGO:00421131610.030
skeletal system morphogenesisGO:00487052030.030
regulation of anatomical structure sizeGO:00900661780.030
divalent inorganic cation transportGO:00725111780.030
blood circulationGO:00080151950.030
transmembrane receptor protein tyrosine kinase signaling pathwayGO:00071692470.030
epithelial tube morphogenesisGO:00605623030.029
nuclear divisionGO:00002801580.029
mapk cascadeGO:00001652810.029
response to extracellular stimulusGO:00099911270.029
carbohydrate derivative catabolic processGO:19011362310.029
adult behaviorGO:00305341350.029
cellular response to hormone stimulusGO:00328701500.029
cellular calcium ion homeostasisGO:00068741190.029
urogenital system developmentGO:00016552610.029
regulation of transmembrane transportGO:00347621280.029
anatomical structure homeostasisGO:00602491450.029
transmission of nerve impulseGO:0019226760.029
limb morphogenesisGO:00351081490.029
wound healingGO:00420601570.029
inorganic cation transmembrane transportGO:00986622070.029
dna metabolic processGO:00062593030.028
purine ribonucleoside triphosphate metabolic processGO:00092052200.028
multicellular organismal signalingGO:0035637910.028
axonogenesisGO:00074092740.028
organonitrogen compound biosynthetic processGO:19015661920.028
peptide transportGO:00158331330.028
digestive system developmentGO:00551232000.028
amide transportGO:00428861380.028
inorganic ion transmembrane transportGO:00986602340.028
positive regulation of protein modification processGO:00314012990.028
negative regulation of cellular amine metabolic processGO:003323910.028
circulatory system processGO:00030131970.027
cytoplasmic transportGO:00164822340.027
regulation of ossificationGO:00302781120.027
regulation of ion transportGO:00432692150.027
regulation of ion transmembrane transportGO:00347651190.027
cellular response to cytokine stimulusGO:00713451890.027
regulation of cell motilityGO:20001452360.026
organelle fissionGO:00482851700.026
posttranscriptional regulation of gene expressionGO:00106081550.026
organonitrogen compound catabolic processGO:19015652640.026
negative regulation of phosphorylationGO:00423261660.026
divalent inorganic cation homeostasisGO:00725071380.026
leukocyte differentiationGO:00025213420.026
regulation of organelle organizationGO:00330432890.026
g protein coupled receptor signaling pathwayGO:00071862430.026
purine ribonucleotide catabolic processGO:00091542080.026
neuron migrationGO:00017641220.026
purine nucleoside metabolic processGO:00422782410.026
positive regulation of apoptotic processGO:00430652170.025
regulation of neuron differentiationGO:00456642810.025
placenta developmentGO:00018901400.025
developmental growth involved in morphogenesisGO:00605601380.025
cellular nitrogen compound catabolic processGO:00442702800.025
aromatic compound catabolic processGO:00194392860.025
nucleoside triphosphate metabolic processGO:00091412300.025
cellular response to organonitrogen compoundGO:00714171450.025
negative regulation of molecular functionGO:00440922580.025
glycosyl compound metabolic processGO:19016572460.024
regulation of cellular component biogenesisGO:00440871810.024
negative regulation of cell proliferationGO:00082852960.024
regulation of cell cycle processGO:00105641600.024
alcohol metabolic processGO:00060661160.024
regulation of apoptotic signaling pathwayGO:20012331970.024
response to inorganic substanceGO:0010035960.024
myeloid cell differentiationGO:00300992330.024
cellular response to growth factor stimulusGO:00713631970.024
reactive oxygen species metabolic processGO:0072593840.024
carbohydrate metabolic processGO:00059752300.024
regulation of cytokine productionGO:00018172660.024
ear morphogenesisGO:00424711180.023
cell maturationGO:00484691270.023
blood vessel morphogenesisGO:00485142850.023
negative regulation of cellular protein metabolic processGO:00322692470.023
rho protein signal transductionGO:0007266320.023
regulation of purine nucleotide metabolic processGO:19005421690.023
ribonucleotide catabolic processGO:00092612080.023
morphogenesis of a branching structureGO:00017632030.023
inflammatory responseGO:00069542440.023
heart morphogenesisGO:00030071780.023
lymphocyte differentiationGO:00300982420.023
ear developmentGO:00435832000.023
carbohydrate derivative biosynthetic processGO:19011371830.023
response to peptide hormoneGO:00434341270.022
positive regulation of protein phosphorylationGO:00019342420.022
nucleoside metabolic processGO:00091162460.022
cell growthGO:00160491300.022
peptide hormone secretionGO:00300721090.022
regulation of establishment of protein localizationGO:00702011810.022
cerebral cortex developmentGO:0021987860.022
purine nucleotide catabolic processGO:00061952110.022
maintenance of locationGO:0051235890.022
response to growth factorGO:00708481980.022
purine nucleoside triphosphate metabolic processGO:00091442260.022
response to nutrient levelsGO:00316671090.022
gastrulationGO:00073691160.022
positive regulation of neuron differentiationGO:00456661410.022
sulfur compound metabolic processGO:00067901000.022
fat cell differentiationGO:00454441600.022
purine ribonucleoside catabolic processGO:00461302050.022
digestive tract morphogenesisGO:00485461470.022
organic anion transportGO:00157111370.022
regulation of mitotic cell cycleGO:00073461260.022
divalent metal ion transportGO:00708381720.022
regulation of hydrolase activityGO:00513362460.022
nucleoside phosphate catabolic processGO:19012922220.021
mitotic cell cycle processGO:19030471590.021
embryonic placenta developmentGO:0001892980.021
organophosphate catabolic processGO:00464342320.021
nucleoside catabolic processGO:00091642060.021
regulation of defense responseGO:00313472330.021
regulation of protein transportGO:00512231630.021
negative regulation of intracellular signal transductionGO:19025321670.021
cellular alcohol biosynthetic processGO:004410830.021
innate immune responseGO:00450871570.021
morphogenesis of a branching epitheliumGO:00611381930.021
positive regulation of cell developmentGO:00107202370.021
regulation of response to woundingGO:19030341890.021
regulation of protein kinase activityGO:00458592320.021
regulation of kinase activityGO:00435492490.021
liver developmentGO:0001889660.021
epithelial cell proliferationGO:00506731740.021
intestinal epithelial structure maintenanceGO:006072940.021
purine ribonucleoside metabolic processGO:00461282410.021
multicellular organismal homeostasisGO:00488711640.021
regulation of hormone levelsGO:00108172110.020
cellular response to acid chemicalGO:0071229680.020
organic hydroxy compound biosynthetic processGO:1901617770.020
protein localization to organelleGO:00333651850.020
sensory perception of mechanical stimulusGO:00509541070.020
purine containing compound catabolic processGO:00725232130.020
actin filament based movementGO:0030048230.020
regulation of cellular catabolic processGO:00313292420.020
sequestering of calcium ionGO:0051208180.020
regulation of lymphocyte activationGO:00512492400.020
protein modification by small protein conjugationGO:00324461870.020
regulation of transferase activityGO:00513382630.020
cartilage developmentGO:00512161400.020
appendage morphogenesisGO:00351071490.020
regulation of nucleoside metabolic processGO:00091181300.020
heart processGO:0003015940.020
negative regulation of protein modification processGO:00314001630.020
embryonic appendage morphogenesisGO:00351131260.020
regulation of cell sizeGO:0008361720.020
stem cell differentiationGO:00488632680.020
protein ubiquitinationGO:00165671710.020
purine nucleoside triphosphate catabolic processGO:00091462030.020
carboxylic acid biosynthetic processGO:0046394860.020
carbohydrate homeostasisGO:00335001280.020
single organism cell adhesionGO:00986021560.020
digestive tract developmentGO:00485651900.020
peptide secretionGO:00027901140.019
limb developmentGO:00601731660.019
cell cell junction organizationGO:0045216720.019
chemotaxisGO:00069352470.019
immune effector processGO:00022523210.019
positive regulation of nervous system developmentGO:00519622210.019
hepaticobiliary system developmentGO:0061008670.019
cellular alcohol metabolic processGO:004410730.019
hormone secretionGO:00468791280.019
macromolecule catabolic processGO:00090572810.019
negative regulation of cellular component organizationGO:00511291940.019
cellular carbohydrate metabolic processGO:00442621190.019
regulation of cell projection organizationGO:00313442060.019
purine ribonucleoside triphosphate catabolic processGO:00092071990.019
t cell activationGO:00421102890.019
embryonic limb morphogenesisGO:00303261260.019
cellular protein complex assemblyGO:00436231160.019
regulation of osteoblast differentiationGO:0045667670.018
inner ear morphogenesisGO:00424721010.018
sensory perception of soundGO:0007605970.018
purine nucleoside catabolic processGO:00061522050.018
nucleotide catabolic processGO:00091662170.018
protein modification by small protein conjugation or removalGO:00706472070.018
cell junction organizationGO:0034330770.018
ribonucleoside catabolic processGO:00424542060.018
central nervous system neuron differentiationGO:00219531620.018
central nervous system neuron developmentGO:0021954670.018
bone morphogenesisGO:0060349780.018
regulation of cell growthGO:0001558910.018
positive regulation of programmed cell deathGO:00430682180.018
nucleoside monophosphate metabolic processGO:0009123850.018
neuron apoptotic processGO:00514021420.018
neuromuscular processGO:0050905990.018
respiratory system developmentGO:00605411900.018
angiogenesisGO:00015252010.018
organic acid transportGO:00158491010.018
intracellular protein transportGO:00068862040.018
calcium ion transportGO:00068161590.018
respiratory tube developmentGO:00303231670.018
regulation of cell migrationGO:00303342190.017
negative regulation of phosphate metabolic processGO:00459361840.017
cellular protein catabolic processGO:00442571550.017
cell divisionGO:00513011200.017
blastocyst developmentGO:0001824800.017
regulation of cellular response to stressGO:00801351590.017
protein maturationGO:00516041760.017
extrinsic apoptotic signaling pathwayGO:00971911260.017
stem cell developmentGO:00488642190.017
rhythmic processGO:00485111740.017
regulation of cell activationGO:00508652890.017
endomembrane system organizationGO:00102561470.017
mitotic cell cycleGO:00002781950.017
negative regulation of nervous system developmentGO:00519611560.017
appendage developmentGO:00487361660.017
fat soluble vitamin biosynthetic processGO:004236240.017
organic acid biosynthetic processGO:0016053860.017
male sex differentiationGO:00466611090.017
small gtpase mediated signal transductionGO:0007264970.017
membrane depolarizationGO:0051899640.017
monocarboxylic acid metabolic processGO:00327871910.017
tissue homeostasisGO:00018941150.017
glycosyl compound catabolic processGO:19016582060.017
organophosphate biosynthetic processGO:00904071220.017
extracellular structure organizationGO:00430621480.017
organ growthGO:00352651170.016
response to molecule of bacterial originGO:00022371430.016
alcohol biosynthetic processGO:0046165430.016
protein catabolic processGO:00301632210.016
mesonephros developmentGO:0001823970.016
regulation of action potentialGO:009890040.016
endocrine system developmentGO:0035270980.016
regulation of intracellular transportGO:00323861590.016
positive regulation of mapk cascadeGO:00434101700.016
glycoprotein metabolic processGO:00091001160.016
cardiac muscle cell contractionGO:008600370.016
ribonucleoside monophosphate metabolic processGO:0009161800.016
negative regulation of immune system processGO:00026832090.016
fatty acid metabolic processGO:00066311210.016
sequestering of metal ionGO:0051238190.016
organelle localizationGO:00516401790.016
regulation of cell adhesionGO:00301551540.016
leukocyte proliferationGO:00706611720.016
biomineral tissue developmentGO:0031214640.016
striated muscle tissue developmentGO:00147062930.016
monosaccharide metabolic processGO:00059961060.016
insulin secretionGO:0030073890.015
negative regulation of cell cycleGO:00457861230.015
regulation of protein catabolic processGO:00421761080.015
nuclear transportGO:00511691390.015
cofactor metabolic processGO:0051186800.015
ribonucleoside triphosphate catabolic processGO:00092031990.015
regulation of heart contractionGO:0008016770.015
regulation of peptide transportGO:0090087910.015
chondrocyte differentiationGO:0002062720.015
sulfur compound biosynthetic processGO:0044272370.015
actin cytoskeleton organizationGO:00300362200.015
dendrite developmentGO:00163581150.015
multicellular organism growthGO:00352641610.015
exocytosisGO:00068871210.015
norepinephrine secretionGO:004824320.015
negative regulation of cytokine productionGO:0001818840.015
tube formationGO:00351481400.015
positive regulation of cell deathGO:00109422240.015
muscle tissue developmentGO:00605373080.015
regulation of proteolysisGO:00301621640.015
cellular response to dna damage stimulusGO:00069742070.015
glucose homeostasisGO:00425931280.015
lymphocyte proliferationGO:00466511640.015
vitamin d3 metabolic processGO:007064030.015
heart contractionGO:0060047930.015
spermatid differentiationGO:00485151150.015
tissue remodelingGO:00487711020.015
protein targetingGO:00066051430.015
oocyte constructionGO:000730820.015
neural tube formationGO:00018411080.015
hair follicle developmentGO:0001942850.015
membrane organizationGO:00610242450.015
positive regulation of cellular catabolic processGO:00313311480.015
atp metabolic processGO:0046034750.014
regulation of translationGO:0006417710.014
cellular macromolecule catabolic processGO:00442652060.014
pallium developmentGO:00215431200.014
cognitionGO:00508901490.014
mesenchyme developmentGO:00604851520.014
regulation of feeding behaviorGO:006025930.014
erk1 and erk2 cascadeGO:0070371770.014
regulation of leukocyte proliferationGO:00706631210.014
response to organonitrogen compoundGO:00102432460.014
meiotic cell cycleGO:00513211220.014
bone mineralizationGO:0030282540.014
muscle contractionGO:00069361010.014
intrinsic apoptotic signaling pathwayGO:00971931320.014
testosterone biosynthetic processGO:006137020.014
nucleocytoplasmic transportGO:00069131390.014
purine nucleoside monophosphate metabolic processGO:0009126810.014
muscle system processGO:00030121410.014
midgut developmentGO:000749440.014
cellular response to organic cyclic compoundGO:0071407870.014
cardiac ventricle developmentGO:0003231830.014
cellular modified amino acid metabolic processGO:0006575630.014
regulation of neuron projection developmentGO:00109751690.014
mesenchymal cell differentiationGO:00487621070.014
germ cell developmentGO:00072811850.014
positive regulation of growthGO:00459271040.014
neural tube developmentGO:00219151600.014
synapse organizationGO:00508081250.014
regulation of blood circulationGO:1903522930.014
embryonic skeletal system developmentGO:00487061200.014
axon ensheathmentGO:0008366760.014
myeloid leukocyte differentiationGO:00025731190.014
actin mediated cell contractionGO:0070252150.014
regulation of multi organism processGO:00439001110.014
sa node cell to atrial cardiac muscle cell signallingGO:008601840.014
regulation of endopeptidase activityGO:0052548890.014
multi multicellular organism processGO:00447061090.014
mesenchymal cell developmentGO:0014031930.013
regulation of protein maturationGO:1903317960.013
ensheathment of neuronsGO:0007272760.013
columnar cuboidal epithelial cell differentiationGO:0002065820.013
hexose metabolic processGO:0019318980.013
cell fate commitmentGO:00451652100.013
molting cycleGO:0042303900.013
glucose metabolic processGO:0006006920.013
positive regulation of secretionGO:00510471300.013
hair cycleGO:0042633900.013
response to starvationGO:0042594650.013
extracellular matrix organizationGO:00301981470.013
detection of abiotic stimulusGO:0009582600.013
response to light stimulusGO:00094161350.013
kidney epithelium developmentGO:00720731210.013
lung developmentGO:00303241640.013
regulation of nucleotide catabolic processGO:00308111220.013
negative regulation of phosphorus metabolic processGO:00105631840.013
protein processingGO:00164851630.013
cell substrate adhesionGO:00315891300.013
glycerolipid metabolic processGO:00464861220.013
septum primum developmentGO:000328440.013
cellular response to external stimulusGO:0071496880.013
organelle assemblyGO:00709251770.013
response to radiationGO:00093141650.013
adult locomotory behaviorGO:0008344910.013
regulation of synaptic growth at neuromuscular junctionGO:000858240.013
neutral lipid metabolic processGO:0006638570.013
regulation of muscle system processGO:0090257800.013
purine ribonucleoside monophosphate metabolic processGO:0009167800.013
protein secretionGO:00093061110.013
regulation of protein secretionGO:0050708820.013
defecationGO:003042110.013
glycerophospholipid metabolic processGO:0006650710.013
anion transmembrane transportGO:0098656710.013
phenol containing compound metabolic processGO:0018958600.013
vitamin d biosynthetic processGO:004236830.013
axon guidanceGO:00074111410.012
cellular response to peptide hormone stimulusGO:0071375920.012
response to lipopolysaccharideGO:00324961280.012
lipid transportGO:0006869980.012
actin filament organizationGO:00070151130.012
regulation of actin filament based processGO:0032970990.012
regulation of reproductive processGO:2000241660.012
regulation of cellular carbohydrate metabolic processGO:0010675750.012
cell junction assemblyGO:0034329520.012
regulation of fat cell differentiationGO:0045598810.012
diencephalon developmentGO:0021536630.012
meiotic nuclear divisionGO:00071261150.012
cellular response to starvationGO:0009267570.012
regulation of blood pressureGO:0008217930.012
response to acid chemicalGO:00011011110.012
cytokine mediated signaling pathwayGO:00192211150.012
positive regulation of hydrolase activityGO:00513451480.012
renal system processGO:0003014480.012
lateral inhibitionGO:004633110.012
single organismal cell cell adhesionGO:00163371310.012
proteolysis involved in cellular protein catabolic processGO:00516031470.012
establishment of blood nerve barrierGO:000806530.012
positive regulation of nucleotide metabolic processGO:00459811140.012
mesoderm developmentGO:00074981000.012
ubiquitin dependent protein catabolic processGO:00065111290.012
protein importGO:00170381010.012
regulation of renin secretion into blood streamGO:190013340.012
developmental cell growthGO:0048588840.012
norepinephrine transportGO:001587420.012
glycoprotein biosynthetic processGO:0009101890.012
regulation of vesicle mediated transportGO:00606271390.012
regulation of extent of cell growthGO:0061387520.012
negative regulation of growthGO:0045926990.012
regulation of erk1 and erk2 cascadeGO:0070372710.012
cardiac muscle tissue developmentGO:00487381300.012
regulation of peptidase activityGO:0052547960.012
androgen biosynthetic processGO:000670240.012
regulation of epithelial cell proliferationGO:00506781410.012
coenzyme metabolic processGO:0006732520.012
regulation of cytoplasmic transportGO:19036491120.012
primary neural tube formationGO:0014020950.012
modification dependent macromolecule catabolic processGO:00436321330.012
regulation of cellular component sizeGO:00325351210.012
regulation of lipid metabolic processGO:00192161180.012
lipid localizationGO:00108761260.012
regulation of neurotransmitter levelsGO:0001505870.012
dephosphorylationGO:00163111290.012
response to peptideGO:19016521360.012
gliogenesisGO:00420631410.012
thyroid stimulating hormone secreting cell differentiationGO:006012940.011
tube closureGO:0060606910.011
embryonic epithelial tube formationGO:00018381300.011
wnt signaling pathwayGO:00160551880.011

Pcsk9 disease predictions

Disease predictions are made from cross-annotation of human disease genes to the identified functional analogs in mouse and predicted with the mouse functional network.

DiseaseDO term IDSizeProbabilityFunc Analog Org
nervous system diseaseDOID:86300.023
disease of anatomical entityDOID:700.023
disease of metabolismDOID:001466700.017
immune system diseaseDOID:291400.015
inherited metabolic disorderDOID:65500.014
musculoskeletal system diseaseDOID:1700.013