Mus musculus

49 known processes

Pcsk4

proprotein convertase subtilisin/kexin type 4

(Aliases: MGC63195,NEC 3,PC4,AI647044,L21221,SPC5,NEC3)

Pcsk4 biological process predictions


Filter by process size:
Biological processGO term IDProcess sizeProbabilityFunc Analog Org
transmembrane transportGO:00550854120.594
sperm motilityGO:0030317470.556
negative regulation of hormone metabolic processGO:003235140.543
ion transmembrane transportGO:00342203610.532
metal ion homeostasisGO:00550651890.409
cation homeostasisGO:00550802120.343
negative regulation of hormone biosynthetic processGO:003235340.305
nucleobase containing small molecule metabolic processGO:00550863520.298
cation transportGO:00068123990.283
inorganic ion transmembrane transportGO:00986602340.275
dephosphorylationGO:00163111290.265
inorganic cation transmembrane transportGO:00986622070.263
cation transmembrane transportGO:00986552660.260
sodium ion transportGO:0006814730.255
glutamate receptor signaling pathwayGO:0007215350.242
cellular ion homeostasisGO:00068731650.231
regulation of muscle system processGO:0090257800.199
developmental maturationGO:00217001930.196
steroid metabolic processGO:00082021190.180
negative regulation of molecular functionGO:00440922580.144
potassium ion transportGO:0006813520.136
adult behaviorGO:00305341350.133
potassium ion transmembrane transportGO:0071805430.114
regulation of hormone levelsGO:00108172110.109
Mouse Worm
muscle contractionGO:00069361010.105
sodium ion transmembrane transportGO:0035725490.104
cell type specific apoptotic processGO:00972852680.103
potassium ion homeostasisGO:005507540.102
cellular homeostasisGO:00197252400.102
cofactor metabolic processGO:0051186800.102
purine ribonucleoside catabolic processGO:00461302050.101
ribonucleotide metabolic processGO:00092592910.100
ribonucleoside triphosphate metabolic processGO:00091992200.094
regulation of ion transmembrane transportGO:00347651190.089
regulation of cellular amino acid metabolic processGO:000652150.089
germ cell developmentGO:00072811850.088
regulation of system processGO:00440572000.087
lipid transportGO:0006869980.083
camera type eye developmentGO:00430102660.083
muscle system processGO:00030121410.082
hormone secretionGO:00468791280.082
cellular calcium ion homeostasisGO:00068741190.080
determination of left right symmetryGO:0007368800.079
Mouse
blood circulationGO:00080151950.076
lipid biosynthetic processGO:00086101790.076
male gamete generationGO:00482322850.075
locomotory behaviorGO:00076261950.075
cellular amino acid metabolic processGO:00065201030.075
organic cyclic compound catabolic processGO:19013612950.074
spermatid differentiationGO:00485151150.074
sensory perceptionGO:00076002450.073
sensory organ morphogenesisGO:00905962420.071
multicellular organismal homeostasisGO:00488711640.070
monovalent inorganic cation homeostasisGO:0055067330.070
purine ribonucleotide metabolic processGO:00091502900.070
nucleoside monophosphate metabolic processGO:0009123850.069
heterocycle catabolic processGO:00467002800.069
atp metabolic processGO:0046034750.068
cellular potassium ion transportGO:0071804430.067
fat cell differentiationGO:00454441600.066
ribonucleoside catabolic processGO:00424542060.066
purine ribonucleoside triphosphate metabolic processGO:00092052200.066
nucleoside triphosphate catabolic processGO:00091432050.065
cerebellum developmentGO:0021549770.065
organic anion transportGO:00157111370.065
spermatogenesisGO:00072832840.064
cellular metal ion homeostasisGO:00068751510.064
purine ribonucleoside monophosphate metabolic processGO:0009167800.063
development of primary male sexual characteristicsGO:0046546880.062
regulation of neurotransmitter levelsGO:0001505870.062
ribonucleoside monophosphate metabolic processGO:0009161800.062
gland developmentGO:00487323300.062
nucleoside triphosphate metabolic processGO:00091412300.062
sensory perception of soundGO:0007605970.061
purine nucleotide metabolic processGO:00061633020.061
regulation of steroid biosynthetic processGO:0050810260.061
purine ribonucleotide catabolic processGO:00091542080.061
regulation of steroid metabolic processGO:0019218390.060
peptide secretionGO:00027901140.060
cellular response to hormone stimulusGO:00328701500.058
urogenital system developmentGO:00016552610.056
Mouse
nucleoside phosphate metabolic processGO:00067533380.056
negative regulation of lipid metabolic processGO:0045833300.056
epithelial tube morphogenesisGO:00605623030.056
heart morphogenesisGO:00030071780.055
calcium ion homeostasisGO:00550741270.055
insulin secretionGO:0030073890.055
negative regulation of steroid biosynthetic processGO:001089480.055
ribonucleoside metabolic processGO:00091192450.054
heart contractionGO:0060047930.054
divalent inorganic cation homeostasisGO:00725071380.054
peptide transportGO:00158331330.054
fluid transportGO:0042044140.053
carbohydrate derivative catabolic processGO:19011362310.053
regulation of peptide secretionGO:0002791770.053
cellular amine metabolic processGO:0044106440.052
regulation of cellular amine metabolic processGO:0033238200.052
atp catabolic processGO:0006200550.051
regulation of peptide hormone secretionGO:0090276750.051
nucleoside monophosphate catabolic processGO:0009125590.051
microtubule based processGO:00070172360.051
regulation of organ morphogenesisGO:20000271440.051
purine ribonucleoside metabolic processGO:00461282410.051
regulation of ion transportGO:00432692150.051
adult locomotory behaviorGO:0008344910.051
regulation of cell cycleGO:00517262810.050
regulation of phGO:0006885260.050
response to organic cyclic compoundGO:00140701980.050
cellular lipid metabolic processGO:00442553230.050
skeletal system developmentGO:00015013560.049
Mouse
ribonucleoside monophosphate catabolic processGO:0009158570.049
steroid biosynthetic processGO:0006694470.048
striated muscle tissue developmentGO:00147062930.048
carboxylic acid transportGO:00469421000.048
spermatid developmentGO:00072861080.048
purine containing compound metabolic processGO:00725213110.047
embryonic organ morphogenesisGO:00485622760.047
reactive oxygen species metabolic processGO:0072593840.047
carbohydrate metabolic processGO:00059752300.047
cilium morphogenesisGO:00602711020.046
purine containing compound catabolic processGO:00725232130.046
hydrogen ion transmembrane transportGO:1902600250.046
aromatic compound catabolic processGO:00194392860.046
epithelial cell developmentGO:00020641590.045
retina development in camera type eyeGO:00600411190.044
regulation of hormone secretionGO:0046883880.044
response to light stimulusGO:00094161350.044
t cell activationGO:00421102890.043
regulation of membrane potentialGO:00423911920.042
nucleoside phosphate catabolic processGO:19012922220.042
meiotic nuclear divisionGO:00071261150.042
kidney developmentGO:00018222130.041
Mouse
neuron deathGO:00709971540.041
regionalizationGO:00030023370.040
Mouse
nitrogen compound transportGO:00717052710.040
neurotransmitter transportGO:0006836760.040
mesenchyme developmentGO:00604851520.039
ribonucleoside triphosphate catabolic processGO:00092031990.039
epidermis developmentGO:00085441870.039
renal system developmentGO:00720012250.039
Mouse
glycosyl compound metabolic processGO:19016572460.039
negative regulation of cell proliferationGO:00082852960.039
cellular chemical homeostasisGO:00550822150.039
cerebellum morphogenesisGO:0021587420.039
peptide hormone secretionGO:00300721090.039
embryonic heart tube morphogenesisGO:0003143510.039
skin developmentGO:00435882200.039
anion transportGO:00068201770.039
protein localization to nucleusGO:00345041210.038
actin cytoskeleton organizationGO:00300362200.038
organelle assemblyGO:00709251770.038
nucleocytoplasmic transportGO:00069131390.038
synaptic transmissionGO:00072683290.038
organophosphate catabolic processGO:00464342320.038
nuclear transportGO:00511691390.038
organelle fissionGO:00482851700.037
cop9 signalosome assemblyGO:001038720.036
regulation of body fluid levelsGO:00508781620.036
organic hydroxy compound metabolic processGO:19016152030.036
nucleotide metabolic processGO:00091173320.036
germ line stem cell divisionGO:004207820.036
positive regulation of cellular amino acid metabolic processGO:004576430.035
male meiosisGO:0007140370.035
regulation of cellular ketone metabolic processGO:0010565660.035
cellular response to lipidGO:00713961450.035
anatomical structure homeostasisGO:00602491450.035
cofactor transportGO:005118140.035
fat soluble vitamin biosynthetic processGO:004236240.035
glycosyl compound catabolic processGO:19016582060.034
cellular component assembly involved in morphogenesisGO:00109271390.034
skeletal muscle cell differentiationGO:0035914660.034
cell maturationGO:00484691270.033
regulation of striated muscle contractionGO:0006942250.033
regulation of transporter activityGO:0032409570.033
nephric duct formationGO:007217940.032
cellular divalent inorganic cation homeostasisGO:00725031270.032
hormone biosynthetic processGO:0042446160.032
regulation of cardioblast differentiationGO:005189030.032
hormone metabolic processGO:0042445860.032
Mouse Worm
response to radiationGO:00093141650.032
regulation of heart contractionGO:0008016770.032
purine nucleoside metabolic processGO:00422782410.032
cellular ketone metabolic processGO:0042180840.032
response to glycosideGO:190341620.031
amide transportGO:00428861380.031
generation of precursor metabolites and energyGO:00060911030.031
determination of heart left right asymmetryGO:0061371480.031
sensory perception of mechanical stimulusGO:00509541070.031
purine nucleoside triphosphate catabolic processGO:00091462030.030
hepaticobiliary system developmentGO:0061008670.030
transition metal ion transportGO:0000041380.030
embryonic epithelial tube formationGO:00018381300.030
actin filament organizationGO:00070151130.030
purine nucleoside monophosphate metabolic processGO:0009126810.030
regulation of neuron apoptotic processGO:00435231220.030
glucocorticoid biosynthetic processGO:000670450.030
iron ion homeostasisGO:0055072360.029
cellular response to organic cyclic compoundGO:0071407870.029
response to oxidative stressGO:00069791230.029
purine nucleoside triphosphate metabolic processGO:00091442260.029
muscle tissue developmentGO:00605373080.029
amine metabolic processGO:0009308450.029
response to temperature stimulusGO:0009266550.029
negative regulation of steroid metabolic processGO:004593980.029
triglyceride metabolic processGO:0006641510.029
metencephalon developmentGO:0022037890.029
ribose phosphate metabolic processGO:00196932910.029
nucleoside metabolic processGO:00091162460.029
regulation of anatomical structure sizeGO:00900661780.029
regulation of oxidative phosphorylationGO:000208260.029
nucleotide catabolic processGO:00091662170.028
regulation of voltage gated calcium channel activityGO:190138540.028
cytoplasmic transportGO:00164822340.028
organonitrogen compound catabolic processGO:19015652640.028
monocarboxylic acid transportGO:0015718440.028
multi multicellular organism processGO:00447061090.028
Mouse
acylglycerol metabolic processGO:0006639550.028
regulation of actin filament based processGO:0032970990.028
intracellular protein transportGO:00068862040.028
hydrogen transportGO:0006818350.027
nucleoside catabolic processGO:00091642060.027
positive regulation of ion transportGO:0043270650.027
response to peptide hormoneGO:00434341270.027
cellular response to dna damage stimulusGO:00069742070.026
synapse organizationGO:00508081250.026
heart processGO:0003015940.026
cellular modified amino acid metabolic processGO:0006575630.026
cd4 positive alpha beta t cell activationGO:0035710450.026
positive regulation of striated muscle contractionGO:004598930.026
purine ribonucleoside triphosphate catabolic processGO:00092071990.026
regulation of vitamin metabolic processGO:003065630.026
optic vesicle morphogenesisGO:000340420.026
cellular response to peptideGO:1901653920.026
anatomical structure maturationGO:0071695490.026
negative regulation of hormone secretionGO:0046888200.026
purine nucleoside catabolic processGO:00061522050.025
meiotic cell cycleGO:00513211220.025
regulation of muscle contractionGO:0006937490.025
regulation of lipid transportGO:0032368360.025
lateral inhibitionGO:004633110.025
regulation of hormone metabolic processGO:0032350150.025
negative regulation of phosphate metabolic processGO:00459361840.025
lipid homeostasisGO:0055088630.025
striated muscle contractionGO:0006941450.025
alpha beta t cell differentiationGO:0046632690.024
l serine metabolic processGO:000656320.024
liver developmentGO:0001889660.024
hindbrain morphogenesisGO:0021575460.024
regulation of cellular phGO:0030641120.024
organic acid transportGO:00158491010.024
regulation of homeostatic processGO:00328441820.023
coenzyme metabolic processGO:0006732520.023
cerebellar cortex morphogenesisGO:0021696320.023
epithelial tube formationGO:00721751300.023
regulation of cell cycle processGO:00105641600.023
regulation of blood circulationGO:1903522930.023
meiotic cell cycle processGO:1903046770.023
respiratory system developmentGO:00605411900.023
tissue homeostasisGO:00018941150.023
eye photoreceptor cell differentiationGO:0001754410.023
protein catabolic processGO:00301632210.022
morphogenesis of a branching structureGO:00017632030.022
purine nucleoside monophosphate catabolic processGO:0009128580.022
inner medullary collecting duct developmentGO:007206120.022
macromolecule catabolic processGO:00090572810.022
establishment of protein localization to organelleGO:00725941180.022
asymmetric stem cell divisionGO:009872230.022
regulation of lipid biosynthetic processGO:0046890540.022
learningGO:0007612980.022
response to peptideGO:19016521360.022
negative regulation of cellular protein metabolic processGO:00322692470.022
negative regulation of phosphorus metabolic processGO:00105631840.022
mitochondrion organizationGO:00070051340.021
regulation of cellular component biogenesisGO:00440871810.021
regulation of neuron deathGO:19012141340.021
morphogenesis of embryonic epitheliumGO:00163311590.021
apoptotic process involved in mammary gland involutionGO:006005740.021
cartilage developmentGO:00512161400.021
regulation of secretionGO:00510462740.021
regulation of hydrolase activityGO:00513362460.021
ionotropic glutamate receptor signaling pathwayGO:0035235290.021
neuromuscular processGO:0050905990.021
purine nucleotide catabolic processGO:00061952110.021
positive regulation of cell deathGO:00109422240.021
body fluid secretionGO:0007589530.021
positive regulation of hydrolase activityGO:00513451480.021
response to organonitrogen compoundGO:00102432460.021
closure of optic fissureGO:006138620.021
neuron apoptotic processGO:00514021420.021
glucose metabolic processGO:0006006920.021
regulation of tube sizeGO:0035150570.020
ossificationGO:00015032160.020
muscle adaptationGO:0043500390.020
monosaccharide metabolic processGO:00059961060.020
negative regulation of phosphorylationGO:00423261660.020
cellular response to peptide hormone stimulusGO:0071375920.020
ribonucleotide catabolic processGO:00092612080.020
small molecule biosynthetic processGO:00442831320.020
cd4 positive alpha beta t cell differentiationGO:0043367410.020
dendrite developmentGO:00163581150.020
Worm
regulation of lipid metabolic processGO:00192161180.020
cellular nitrogen compound catabolic processGO:00442702800.020
response to insulinGO:00328681000.020
hexose metabolic processGO:0019318980.020
columnar cuboidal epithelial cell differentiationGO:0002065820.020
regulation of transferase activityGO:00513382630.020
regulation of cellular catabolic processGO:00313292420.020
renal inner medulla developmentGO:007205330.020
carbohydrate homeostasisGO:00335001280.020
cellular response to insulin stimulusGO:0032869780.020
hypophysis morphogenesisGO:004885030.019
intrinsic apoptotic signaling pathwayGO:00971931320.019
apoptotic signaling pathwayGO:00971903060.019
positive regulation of programmed cell deathGO:00430682180.019
memoryGO:0007613580.019
regulation of sodium ion transportGO:0002028290.019
regulation of lymphocyte activationGO:00512492400.019
cell recognitionGO:0008037830.019
negative regulation of protein metabolic processGO:00512482820.019
male meiosis iGO:0007141160.019
regulation of ion transmembrane transporter activityGO:0032412540.019
wnt signaling pathway involved in forebrain neuroblast divisionGO:002187420.019
smooth muscle contractionGO:0006939440.019
microtubule based movementGO:0007018840.019
cell activation involved in immune responseGO:00022631260.019
circulatory system processGO:00030131970.019
regulation of peptide transportGO:0090087910.019
regulation of organ growthGO:0046620610.019
neural tube developmentGO:00219151600.018
nuclear divisionGO:00002801580.018
regulation of calcium ion transmembrane transporter activityGO:1901019200.018
spemann organizer formationGO:006006120.018
positive regulation of growth hormone secretionGO:006012430.018
tube closureGO:0060606910.018
t cell differentiationGO:00302171740.018
connective tissue developmentGO:00614481790.018
response to extracellular stimulusGO:00099911270.018
cholesterol metabolic processGO:0008203560.017
proton transportGO:0015992350.017
positive regulation of mitotic cell cycleGO:0045931410.017
regulation of cell morphogenesis involved in differentiationGO:00107691510.017
skeletal muscle organ developmentGO:00605381630.017
posttranscriptional regulation of gene expressionGO:00106081550.017
male sex differentiationGO:00466611090.017
leukocyte activation involved in immune responseGO:00023661260.017
planar cell polarity pathway involved in pericardium morphogenesisGO:006135420.017
regulation of translationGO:0006417710.017
negative regulation of muscle contractionGO:0045932120.017
lipid localizationGO:00108761260.017
regulation of interleukin 8 secretionGO:200048220.017
regulation of anion transportGO:0044070270.017
transmembrane receptor protein serine threonine kinase signaling pathwayGO:00071781940.017
response to inorganic substanceGO:0010035960.017
negative regulation of stem cell maintenanceGO:190245540.017
ear morphogenesisGO:00424711180.017
energy derivation by oxidation of organic compoundsGO:0015980770.016
regulation of transmembrane transportGO:00347621280.016
cholesterol transportGO:0030301380.016
regulation of mitotic cell cycleGO:00073461260.016
purine ribonucleoside monophosphate catabolic processGO:0009169570.016
small molecule catabolic processGO:0044282710.016
multicellular organismal agingGO:0010259240.016
cellular transition metal ion homeostasisGO:0046916320.016
ph reductionGO:004585180.016
positive regulation of apoptotic processGO:00430652170.016
monocarboxylic acid catabolic processGO:0072329270.016
oocyte axis specificationGO:000730920.016
organonitrogen compound biosynthetic processGO:19015661920.016
Mouse
lipid catabolic processGO:0016042690.016
vitamin d biosynthetic processGO:004236830.016
regulation of protein kinase activityGO:00458592320.016
negative regulation of peptide secretionGO:0002792160.016
compound eye developmentGO:004874910.016
somatotropin secreting cell differentiationGO:006012640.016
response to decreased oxygen levelsGO:0036293590.016
oviduct epithelium developmentGO:003584610.016
forebrain generation of neuronsGO:0021872630.016
negative regulation of neuron deathGO:1901215980.016
sterol metabolic processGO:0016125580.016
regulation of bindingGO:00510981110.015
response to campGO:0051591140.015
regulation of blood pressureGO:0008217930.015
regulation of nucleocytoplasmic transportGO:0046822730.015
clara cell differentiationGO:006048640.015
regulation of smooth muscle contractionGO:0006940220.015
protein targetingGO:00066051430.015
leukocyte proliferationGO:00706611720.015
alpha amino acid biosynthetic processGO:1901607150.015
regulation of cell cycle phase transitionGO:1901987770.015
male gonad developmentGO:0008584880.015
establishment of tissue polarityGO:0007164280.015
purkinje myocyte differentiationGO:000316810.015
divalent inorganic cation transportGO:00725111780.015
regulation of defense responseGO:00313472330.015
epithelial cell morphogenesisGO:0003382410.015
actomyosin structure organizationGO:0031032560.015
lens development in camera type eyeGO:0002088620.015
ras protein signal transductionGO:0007265770.015
protein localization to organelleGO:00333651850.015
cellular response to oxidative stressGO:0034599760.015
oocyte constructionGO:000730820.015
organic acid biosynthetic processGO:0016053860.015
cell fate commitmentGO:00451652100.015
regulation of organelle organizationGO:00330432890.015
inner ear morphogenesisGO:00424721010.015
positive regulation of sodium ion transmembrane transportGO:190230740.015
positive regulation of muscle contractionGO:0045933100.015
visual learningGO:0008542440.015
regulation of proteolysisGO:00301621640.015
cytosolic calcium ion homeostasisGO:0051480700.015
negative regulation of cellular amino acid metabolic processGO:004576300.015
negative regulation of cellular amine metabolic processGO:003323910.015
sterol transportGO:0015918380.015
response to copper ionGO:004668830.014
synapse assemblyGO:0007416560.014
limb morphogenesisGO:00351081490.014
Mouse
embryonic placenta developmentGO:0001892980.014
positive regulation of cardioblast differentiationGO:005189130.014
regulation of isoprenoid metabolic processGO:001974710.014
cervix developmentGO:006006720.014
negative regulation of testosterone biosynthetic processGO:200022510.014
regulation of intracellular transportGO:00323861590.014
regulation of steroid hormone biosynthetic processGO:009003040.014
asymmetric neuroblast divisionGO:005505910.014
protein localization to vacuoleGO:007266540.014
atrial cardiac muscle cell developmentGO:005501420.014
placenta developmentGO:00018901400.014
reactive nitrogen species metabolic processGO:200105700.014
ventricular cardiac myofibril assemblyGO:005500530.014
protein targeting to vacuoleGO:000662330.014
regulation of circadian rhythmGO:0042752580.014
regulation of ossificationGO:00302781120.014
testosterone biosynthetic processGO:006137020.014
organic hydroxy compound biosynthetic processGO:1901617770.014
regulation of fat cell differentiationGO:0045598810.013
transition metal ion homeostasisGO:0055076540.013
mrna metabolic processGO:0016071840.013
vitamin metabolic processGO:0006766230.013
intracellular mrna localizationGO:000829840.013
positive regulation of apoptotic process involved in morphogenesisGO:190233940.013
regulation of metal ion transportGO:00109591060.013
visual behaviorGO:0007632450.013
spinal cord developmentGO:0021510810.013
hematopoietic progenitor cell differentiationGO:00022441430.013
developmental cell growthGO:0048588840.013
cerebellar purkinje cell layer developmentGO:0021680260.013
atrial septum primum morphogenesisGO:000328930.013
protein import into nucleusGO:0006606950.013
regulation of stem cell differentiationGO:2000736500.013
epithelial cell fate commitmentGO:0072148130.013
epithelial cell migrationGO:0010631630.013
single organism nuclear importGO:1902593950.013
regulation of activation of jak2 kinase activityGO:001053410.013
hair follicle developmentGO:0001942850.013
cerebellar cortex developmentGO:0021695480.013
hair cycleGO:0042633900.013
monocarboxylic acid metabolic processGO:00327871910.013
adult walking behaviorGO:0007628410.013
cell junction organizationGO:0034330770.013
limb developmentGO:00601731660.013
Mouse
superoxide metabolic processGO:0006801270.013
regulation of stress activated mapk cascadeGO:0032872690.013
regulation of mapk cascadeGO:00434082480.013
brain segmentationGO:003528430.013
t cell differentiation in thymusGO:0033077770.013
forebrain developmentGO:00309003020.012
positive regulation of rho gtpase activityGO:0032321410.012
protein importGO:00170381010.012
negative regulation of bindingGO:0051100390.012
digestionGO:0007586400.012
translationGO:0006412930.012
glycerolipid metabolic processGO:00464861220.012
chromosome segregationGO:0007059480.012
neurotransmitter uptakeGO:0001504140.012
nephron epithelium developmentGO:0072009920.012
regulation of cell activationGO:00508652890.012
regulation of cytoskeleton organizationGO:00514931220.012
establishment of protein localization to vacuoleGO:007266640.012
heart inductionGO:000312920.012
regulation of cysteine type endopeptidase activityGO:2000116650.012
circadian rhythmGO:00076231140.012
hexose biosynthetic processGO:0019319390.012
neurotransmitter secretionGO:0007269620.012
cellular response to steroid hormone stimulusGO:0071383330.012
apoptotic mitochondrial changesGO:0008637480.012
negative chemotaxisGO:0050919140.012
respiratory gaseous exchangeGO:0007585430.012

Pcsk4 disease predictions

Disease predictions are made from cross-annotation of human disease genes to the identified functional analogs in mouse and predicted with the mouse functional network.

DiseaseDO term IDSizeProbabilityFunc Analog Org
disease of anatomical entityDOID:700.027
nervous system diseaseDOID:86300.027
disease of metabolismDOID:001466700.020
eye and adnexa diseaseDOID:149200.019
sensory system diseaseDOID:005015500.019
retinal diseaseDOID:567900.019
eye diseaseDOID:561400.019
acquired metabolic diseaseDOID:006015800.016
organ system cancerDOID:005068600.013
cancerDOID:16200.013
disease of cellular proliferationDOID:1456600.013