IMP: Integrative Multi-species Prediction

Mus musculus

0 known processes

Hsd17b3

hydroxysteroid (17-beta) dehydrogenase 3

Entrez: 15487
Ensembl: ENSMUSG00000033122
UniProtKB: P70385

Process Predictions
Disease Predictions

Hsd17b3 biological process predictions

Show only novel predictionsHighlight processes of functional analogs

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Biological process	GO term ID	Process size	Probability	Func Analog Org
transmembrane transport	GO:0055085	412	0.179
amine metabolic process	GO:0009308	45	0.168
protein processing	GO:0016485	163	0.166
inorganic ion transmembrane transport	GO:0098660	234	0.148
protein maturation	GO:0051604	176	0.147
regulation of cellular amine metabolic process	GO:0033238	20	0.145
ion transmembrane transport	GO:0034220	361	0.142
cellular response to lipid	GO:0071396	145	0.122
negative regulation of protein metabolic process	GO:0051248	282	0.117
epidermis development	GO:0008544	187	0.097
embryonic organ morphogenesis	GO:0048562	276	0.090
ear development	GO:0043583	200	0.088
lipid biosynthetic process	GO:0008610	179	0.087	Rat
male gamete generation	GO:0048232	285	0.078
muscle cell differentiation	GO:0042692	261	0.078
skeletal system development	GO:0001501	356	0.076
endocrine process	GO:0050886	39	0.075
negative regulation of molecular function	GO:0044092	258	0.075
regulation of stem cell proliferation	GO:0072091	78	0.071
blood vessel morphogenesis	GO:0048514	285	0.070
fertilization	GO:0009566	127	0.070
regulation of cell motility	GO:2000145	236	0.069
myeloid cell differentiation	GO:0030099	233	0.068
sensory perception of sound	GO:0007605	97	0.067
circulatory system process	GO:0003013	197	0.066
striated muscle tissue development	GO:0014706	293	0.065
spermatogenesis	GO:0007283	284	0.064
response to organic cyclic compound	GO:0014070	198	0.064	Rat
blood circulation	GO:0008015	195	0.062
positive regulation of innate immune response	GO:0045089	80	0.060
negative regulation of proteolysis	GO:0045861	74	0.057
cellular response to hormone stimulus	GO:0032870	150	0.057	Rat
cellular amino acid metabolic process	GO:0006520	103	0.055
regulation of cell migration	GO:0030334	219	0.055
germ cell development	GO:0007281	185	0.055
skin development	GO:0043588	220	0.054
regulation of cellular ketone metabolic process	GO:0010565	66	0.053
regulation of striated muscle cell differentiation	GO:0051153	81	0.053
positive regulation of cytokine production	GO:0001819	174	0.052
single organism cell adhesion	GO:0098602	156	0.051
learning or memory	GO:0007611	148	0.051
sensory perception of mechanical stimulus	GO:0050954	107	0.050
positive regulation of t cell activation	GO:0050870	101	0.050
cell cell recognition	GO:0009988	44	0.050
cellular amine metabolic process	GO:0044106	44	0.050
response to steroid hormone	GO:0048545	56	0.050	Rat
fat cell differentiation	GO:0045444	160	0.049
cellular response to organic cyclic compound	GO:0071407	87	0.049
response to inorganic substance	GO:0010035	96	0.049	Rat
regulation of hormone levels	GO:0010817	211	0.048
response to drug	GO:0042493	75	0.048
carbohydrate biosynthetic process	GO:0016051	74	0.046
muscle cell development	GO:0055001	133	0.046
cation transmembrane transport	GO:0098655	266	0.045
single fertilization	GO:0007338	82	0.045
regulation of innate immune response	GO:0045088	91	0.045
interspecies interaction between organisms	GO:0044419	83	0.045
leukocyte differentiation	GO:0002521	342	0.044
cell adhesion	GO:0007155	329	0.044
innate immune response	GO:0045087	157	0.044
cation transport	GO:0006812	399	0.042
regulation of leukocyte differentiation	GO:1902105	159	0.041
response to organonitrogen compound	GO:0010243	246	0.040
cellular lipid metabolic process	GO:0044255	323	0.040
cellular ketone metabolic process	GO:0042180	84	0.040
regulation of cellular amino acid metabolic process	GO:0006521	5	0.040
response to peptide hormone	GO:0043434	127	0.040
negative regulation of intracellular signal transduction	GO:1902532	167	0.040
placenta development	GO:0001890	140	0.039
nephron epithelium development	GO:0072009	92	0.039
response to lipopolysaccharide	GO:0032496	128	0.039
single organismal cell cell adhesion	GO:0016337	131	0.039
glycoprotein metabolic process	GO:0009100	116	0.039
cellular response to organonitrogen compound	GO:0071417	145	0.039
skeletal muscle organ development	GO:0060538	163	0.038
regulation of protein transport	GO:0051223	163	0.038
cellular response to peptide hormone stimulus	GO:0071375	92	0.037
sensory perception	GO:0007600	245	0.036
regulation of lymphocyte differentiation	GO:0045619	107	0.036
positive regulation of programmed cell death	GO:0043068	218	0.036
epithelial cell proliferation	GO:0050673	174	0.035
positive regulation of cellular amine metabolic process	GO:0033240	5	0.035
cell type specific apoptotic process	GO:0097285	268	0.035
immune effector process	GO:0002252	321	0.035
regulation of epithelial cell proliferation	GO:0050678	141	0.034
regulation of system process	GO:0044057	200	0.034
inorganic cation transmembrane transport	GO:0098662	207	0.034
regulation of response to wounding	GO:1903034	189	0.034
regulation of lymphocyte activation	GO:0051249	240	0.034
regulation of neuroblast proliferation	GO:1902692	27	0.034
cellular response to gonadotropin stimulus	GO:0071371	4	0.034	Rat
macromolecule catabolic process	GO:0009057	281	0.033
response to peptide	GO:1901652	136	0.032
regulation of myotube differentiation	GO:0010830	62	0.032
regulation of kinase activity	GO:0043549	249	0.032
gland development	GO:0048732	330	0.032
positive regulation of apoptotic process	GO:0043065	217	0.031
regulation of leukocyte mediated immunity	GO:0002703	104	0.031
negative regulation of cell proliferation	GO:0008285	296	0.031
positive regulation of leukocyte differentiation	GO:1902107	86	0.031
development of primary male sexual characteristics	GO:0046546	88	0.031	Rat
membrane organization	GO:0061024	245	0.031
male gonad development	GO:0008584	88	0.030	Rat
positive regulation of lymphocyte activation	GO:0051251	140	0.030
negative regulation of endothelial cell migration	GO:0010596	4	0.030
stem cell proliferation	GO:0072089	117	0.030
tissue remodeling	GO:0048771	102	0.030
muscle tissue development	GO:0060537	308	0.029
morphogenesis of a branching structure	GO:0001763	203	0.029
regulation of transmembrane receptor protein serine threonine kinase signaling pathway	GO:0090092	112	0.029
positive regulation of cellular amino acid metabolic process	GO:0045764	3	0.028
hormone metabolic process	GO:0042445	86	0.028
lymphocyte mediated immunity	GO:0002449	139	0.028
defense response to gram positive bacterium	GO:0050830	50	0.028
regulation of defense response	GO:0031347	233	0.028
developmental maturation	GO:0021700	193	0.028
cellular response to drug	GO:0035690	15	0.027
sodium ion transmembrane transport	GO:0035725	49	0.027
multicellular organism growth	GO:0035264	161	0.027
glucose metabolic process	GO:0006006	92	0.027
chromatin organization	GO:0006325	206	0.027
regulation of apoptotic signaling pathway	GO:2001233	197	0.027
negative regulation of multi organism process	GO:0043901	68	0.026
positive regulation of lymphocyte differentiation	GO:0045621	61	0.026
response to insulin	GO:0032868	100	0.026
leukocyte mediated cytotoxicity	GO:0001909	62	0.026
positive regulation of protein kinase activity	GO:0045860	144	0.026
asymmetric stem cell division	GO:0098722	3	0.026
oogenesis	GO:0048477	56	0.026
wnt signaling pathway	GO:0016055	188	0.025
carbohydrate derivative biosynthetic process	GO:1901137	183	0.025
protein oligomerization	GO:0051259	67	0.025
regulation of protein processing	GO:0070613	96	0.025
leukocyte mediated immunity	GO:0002443	174	0.025
regulation of skeletal muscle fiber development	GO:0048742	36	0.025
cartilage development	GO:0051216	140	0.025
cellular chemical homeostasis	GO:0055082	215	0.025
cell maturation	GO:0048469	127	0.025
urogenital system development	GO:0001655	261	0.025
gonad development	GO:0008406	141	0.025	Rat
multi multicellular organism process	GO:0044706	109	0.025
nephron development	GO:0072006	109	0.025
cell killing	GO:0001906	67	0.025
cytoplasmic transport	GO:0016482	234	0.025
activation of immune response	GO:0002253	138	0.024
negative regulation of hydrolase activity	GO:0051346	71	0.024
multicellular organismal homeostasis	GO:0048871	164	0.024
regulation of hydrolase activity	GO:0051336	246	0.024
positive regulation of immune effector process	GO:0002699	107	0.024
myeloid leukocyte differentiation	GO:0002573	119	0.024
t cell activation	GO:0042110	289	0.023
eosinophil migration	GO:0072677	3	0.023
response to oxygen levels	GO:0070482	62	0.023
adult behavior	GO:0030534	135	0.023
myotube differentiation	GO:0014902	105	0.023
negative regulation of protein processing	GO:0010955	79	0.023
positive regulation of neuroblast proliferation	GO:0002052	19	0.023
regulation of membrane protein ectodomain proteolysis	GO:0051043	3	0.022
regulation of establishment of protein localization	GO:0070201	181	0.022
inflammatory response	GO:0006954	244	0.022
cellular homeostasis	GO:0019725	240	0.022
regulation of myeloid cell differentiation	GO:0045637	96	0.022
protein localization to organelle	GO:0033365	185	0.021
cellular response to acid chemical	GO:0071229	68	0.021
symbiosis encompassing mutualism through parasitism	GO:0044403	83	0.021
negative regulation of cellular protein metabolic process	GO:0032269	247	0.021
response to molecule of bacterial origin	GO:0002237	143	0.021
positive regulation of thymocyte migration	GO:2000412	2	0.021
digestive tract development	GO:0048565	190	0.021
dephosphorylation	GO:0016311	129	0.020
cell differentiation involved in kidney development	GO:0061005	33	0.020
blastocyst development	GO:0001824	80	0.020
epithelial tube morphogenesis	GO:0060562	303	0.020
t cell differentiation	GO:0030217	174	0.020
positive regulation of inflammatory response	GO:0050729	47	0.020
positive regulation of t cell differentiation	GO:0045582	52	0.020
activation of innate immune response	GO:0002218	56	0.020
homeostasis of number of cells	GO:0048872	210	0.020
positive regulation of protein serine threonine kinase activity	GO:0071902	106	0.020
endocrine system development	GO:0035270	98	0.019
connective tissue development	GO:0061448	179	0.019
cell chemotaxis	GO:0060326	81	0.019
muscle fiber development	GO:0048747	76	0.019
rhythmic process	GO:0048511	174	0.019
spermatid development	GO:0007286	108	0.019
positive regulation of nervous system development	GO:0051962	221	0.019
intracellular protein transport	GO:0006886	204	0.019
embryonic placenta development	GO:0001892	98	0.019
sperm motility	GO:0030317	47	0.019
interaction with symbiont	GO:0051702	14	0.019
cellular response to lipopolysaccharide	GO:0071222	77	0.019
regulation of cell cycle	GO:0051726	281	0.018
regulation of t cell differentiation	GO:0045580	83	0.018
regulation of angiogenesis	GO:0045765	81	0.018
response to estrogen	GO:0043627	24	0.018	Rat
regulation of protein localization	GO:0032880	231	0.018
regulation of neuron apoptotic process	GO:0043523	122	0.018
mitotic cell cycle	GO:0000278	195	0.018
leukocyte homeostasis	GO:0001776	79	0.018
reactive oxygen species metabolic process	GO:0072593	84	0.018
body morphogenesis	GO:0010171	45	0.018
positive regulation of cell death	GO:0010942	224	0.018
potassium ion transmembrane transport	GO:0071805	43	0.018
methylation	GO:0032259	134	0.018
regulation of cellular component biogenesis	GO:0044087	181	0.018
regulation of eosinophil migration	GO:2000416	2	0.017
male sex differentiation	GO:0046661	109	0.017	Rat
negative regulation of leukocyte differentiation	GO:1902106	51	0.017
regulation of metal ion transport	GO:0010959	106	0.017
neuron death	GO:0070997	154	0.017
nitrogen compound transport	GO:0071705	271	0.017
binding of sperm to zona pellucida	GO:0007339	34	0.017
immune response regulating signaling pathway	GO:0002764	125	0.017
nucleotide metabolic process	GO:0009117	332	0.017
cell recognition	GO:0008037	83	0.017
sperm egg recognition	GO:0035036	37	0.017
cellular response to growth factor stimulus	GO:0071363	197	0.017
branching morphogenesis of an epithelial tube	GO:0048754	159	0.017
regulation of protein maturation	GO:1903317	96	0.017
dna metabolic process	GO:0006259	303	0.017
endocytosis	GO:0006897	168	0.017
regulation of angiotensin levels in blood	GO:0002002	4	0.017
posttranscriptional regulation of gene expression	GO:0010608	155	0.017
cellular response to abiotic stimulus	GO:0071214	56	0.016
positive regulation of defense response	GO:0031349	124	0.016
chromatin modification	GO:0016568	187	0.016
nephron tubule development	GO:0072080	84	0.016
cellular response to steroid hormone stimulus	GO:0071383	33	0.016
regulation of microvillus organization	GO:0032530	3	0.016
regulation of secretion	GO:0051046	274	0.016
sequestering of metal ion	GO:0051238	19	0.016
regulation of lipid metabolic process	GO:0019216	118	0.015
positive regulation of cell motility	GO:2000147	116	0.015
apoptotic signaling pathway	GO:0097190	306	0.015
positive regulation of transferase activity	GO:0051347	167	0.015
protein kinase b signaling	GO:0043491	74	0.015
regulation of endopeptidase activity	GO:0052548	89	0.015
lens development in camera type eye	GO:0002088	62	0.015
positive regulation of leukocyte mediated immunity	GO:0002705	70	0.015
inner ear receptor cell differentiation	GO:0060113	61	0.015
regulation of t cell activation	GO:0050863	170	0.015
regulation of protein kinase b signaling	GO:0051896	56	0.015
lipid localization	GO:0010876	126	0.015
positive regulation of cell activation	GO:0050867	158	0.015
action potential	GO:0001508	78	0.015
pma inducible membrane protein ectodomain proteolysis	GO:0051088	1	0.015
cellular response to cytokine stimulus	GO:0071345	189	0.015
negative regulation of epithelial cell proliferation	GO:0050680	64	0.015
acute inflammatory response	GO:0002526	41	0.015
regulation of blood pressure	GO:0008217	93	0.015
response to acid chemical	GO:0001101	111	0.015	Rat
regulation of auditory receptor cell differentiation	GO:0045607	4	0.015
hepaticobiliary system development	GO:0061008	67	0.015
lymphocyte differentiation	GO:0030098	242	0.015
proteoglycan metabolic process	GO:0006029	38	0.015
negative regulation of blood vessel endothelial cell migration	GO:0043537	3	0.015
organic hydroxy compound metabolic process	GO:1901615	203	0.015	Rat
hexose metabolic process	GO:0019318	98	0.015
cellular response to peptide	GO:1901653	92	0.015
regulation of proteolysis	GO:0030162	164	0.014
maintenance of location	GO:0051235	89	0.014
glucose transport	GO:0015758	56	0.014
cochlea development	GO:0090102	35	0.014
mapk cascade	GO:0000165	281	0.014
renal system development	GO:0072001	225	0.014
regulation of multi organism process	GO:0043900	111	0.014
transmembrane receptor protein serine threonine kinase signaling pathway	GO:0007178	194	0.014
tumor necrosis factor ligand superfamily member 11 production	GO:0072535	1	0.014
ameboidal type cell migration	GO:0001667	128	0.014
positive regulation of mapk cascade	GO:0043410	170	0.014
regulation of body fluid levels	GO:0050878	162	0.014
heart process	GO:0003015	94	0.014
cellular response to biotic stimulus	GO:0071216	92	0.014
sodium ion transport	GO:0006814	73	0.014
protein secretion	GO:0009306	111	0.014
response to amino acid	GO:0043200	37	0.014
positive regulation of cell migration	GO:0030335	109	0.014
glycerolipid metabolic process	GO:0046486	122	0.013
regulation of myeloid leukocyte differentiation	GO:0002761	58	0.013
macromolecule methylation	GO:0043414	120	0.013
positive regulation of protein modification process	GO:0031401	299	0.013
regulation of renal sodium excretion	GO:0035813	3	0.013
actin cytoskeleton organization	GO:0030036	220	0.013
positive regulation of lipid metabolic process	GO:0045834	40	0.013
striated muscle cell development	GO:0055002	125	0.013
positive regulation of protein kinase b signaling	GO:0051897	32	0.013
regulation of ion transport	GO:0043269	215	0.013
negative regulation of phosphorus metabolic process	GO:0010563	184	0.013
heart contraction	GO:0060047	93	0.013
positive regulation of eosinophil migration	GO:2000418	2	0.013
glucose homeostasis	GO:0042593	128	0.013
female gamete generation	GO:0007292	74	0.013
organic hydroxy compound transport	GO:0015850	93	0.013
wound healing	GO:0042060	157	0.013
negative regulation of protein maturation	GO:1903318	79	0.013
positive regulation of sequence specific dna binding transcription factor activity	GO:0051091	68	0.013
regulation of blood circulation	GO:1903522	93	0.013
positive regulation of protein transport	GO:0051222	93	0.013
neuron apoptotic process	GO:0051402	142	0.013
learning	GO:0007612	98	0.013
carboxylic acid biosynthetic process	GO:0046394	86	0.013
positive regulation of stem cell proliferation	GO:2000648	59	0.013
transmembrane receptor protein tyrosine kinase signaling pathway	GO:0007169	247	0.013
muscle contraction	GO:0006936	101	0.013
carbohydrate metabolic process	GO:0005975	230	0.012
positive regulation of lymphocyte mediated immunity	GO:0002708	62	0.012
regulation of thyroid hormone generation	GO:2000609	4	0.012
detection of stimulus	GO:0051606	84	0.012
dct cell differentiation	GO:0072069	3	0.012
potassium ion transport	GO:0006813	52	0.012
response to extracellular stimulus	GO:0009991	127	0.012	Rat
tumor necrosis factor production	GO:0032640	50	0.012
negative regulation of cell motility	GO:2000146	61	0.012
fatty acid biosynthetic process	GO:0006633	41	0.012
adaptive immune response	GO:0002250	155	0.012
regulation of angiotensin metabolic process	GO:0060177	4	0.012
positive regulation of kinase activity	GO:0033674	155	0.012
organelle localization	GO:0051640	179	0.012
thymocyte migration	GO:0072679	2	0.012
phenol containing compound metabolic process	GO:0018958	60	0.012	Rat
metanephros development	GO:0001656	79	0.012
regulation of thymocyte migration	GO:2000410	2	0.012
peptide metabolic process	GO:0006518	46	0.012
fatty acid metabolic process	GO:0006631	121	0.012
ovulation cycle	GO:0042698	59	0.012
myeloid leukocyte mediated immunity	GO:0002444	42	0.012
negative regulation of cell migration	GO:0030336	59	0.012
cellularization	GO:0007349	1	0.012
positive regulation of camp mediated signaling	GO:0043950	3	0.012
reflex	GO:0060004	22	0.012
granzyme mediated apoptotic signaling pathway	GO:0008626	1	0.012
positive regulation of sodium ion transport	GO:0010765	13	0.012
regulation of actin filament based process	GO:0032970	99	0.012
hexose transport	GO:0008645	56	0.011
chemotaxis	GO:0006935	247	0.011
regulation of glial cell differentiation	GO:0045685	41	0.011
regulation of sequence specific dna binding transcription factor activity	GO:0051090	106	0.011
morphogenesis of a branching epithelium	GO:0061138	193	0.011
negative regulation of vasculature development	GO:1901343	26	0.011
regulation of mapk cascade	GO:0043408	248	0.011
regulation of cytoplasmic transport	GO:1903649	112	0.011
regulation of symbiosis encompassing mutualism through parasitism	GO:0043903	52	0.011
response to alcohol	GO:0097305	48	0.011	Rat
multicellular organismal signaling	GO:0035637	91	0.011
epithelial cell development	GO:0002064	159	0.011
renal sodium excretion	GO:0035812	3	0.011
establishment of protein localization to organelle	GO:0072594	118	0.011
regulation of fat cell differentiation	GO:0045598	81	0.011
cellular ion homeostasis	GO:0006873	165	0.011
regulation of tissue remodeling	GO:0034103	38	0.011
sensory organ morphogenesis	GO:0090596	242	0.011
muscle system process	GO:0003012	141	0.011
leukocyte chemotaxis	GO:0030595	69	0.011
cellular response to oxidative stress	GO:0034599	76	0.011
positive regulation of secretion	GO:0051047	130	0.011
regulation of steroid hormone biosynthetic process	GO:0090030	4	0.011
adaptive immune response based on somatic recombination of immune receptors built from immunoglobulin superfamily domains	GO:0002460	145	0.011
response to oxidative stress	GO:0006979	123	0.011
monocarboxylic acid metabolic process	GO:0032787	191	0.011
extracellular matrix dependent thymocyte migration	GO:0072680	1	0.011
phospholipid metabolic process	GO:0006644	87	0.011
regulation of muscle tissue development	GO:1901861	97	0.011
positive regulation of keratinocyte proliferation	GO:0010838	4	0.011
cognition	GO:0050890	149	0.011
chondrocyte differentiation	GO:0002062	72	0.011
rna interference	GO:0016246	2	0.011
response to hydrogen peroxide	GO:0042542	32	0.011
stem cell development	GO:0048864	219	0.011
spermatid differentiation	GO:0048515	115	0.011
regulation of vasculature development	GO:1901342	88	0.011
divalent metal ion transport	GO:0070838	172	0.011
immune response activating signal transduction	GO:0002757	116	0.011
response to hypoxia	GO:0001666	58	0.010
regulation of protein kinase activity	GO:0045859	232	0.010
nucleocytoplasmic transport	GO:0006913	139	0.010
regulation of gluconeogenesis	GO:0006111	30	0.010
reactive oxygen species biosynthetic process	GO:1903409	8	0.010
monosaccharide biosynthetic process	GO:0046364	44	0.010
bone remodeling	GO:0046849	53	0.010
regulation of systemic arterial blood pressure	GO:0003073	61	0.010
cellular response to molecule of bacterial origin	GO:0071219	83	0.010
cellular response to follicle stimulating hormone stimulus	GO:0071372	1	0.010
purine nucleoside triphosphate metabolic process	GO:0009144	226	0.010
digestive tract morphogenesis	GO:0048546	147	0.010
g protein coupled receptor signaling pathway	GO:0007186	243	0.010
regulation of secretion by cell	GO:1903530	249	0.010
regulation of systemic arterial blood pressure by renin angiotensin	GO:0003081	20	0.010
regulation of transmembrane transport	GO:0034762	128	0.010
nuclear transport	GO:0051169	139	0.010
cellular macromolecule catabolic process	GO:0044265	206	0.010
regulation of systemic arterial blood pressure mediated by a chemical signal	GO:0003044	33	0.010
positive regulation of cellular component biogenesis	GO:0044089	94	0.010
mechanoreceptor differentiation	GO:0042490	67	0.010

Hsd17b3 disease predictions

Disease predictions are made from cross-annotation of human disease genes to the identified functional analogs in mouse and predicted with the mouse functional network.

	Disease	DO term ID	Size	Probability	Func Analog Org
	inherited metabolic disorder	DOID:655	0	0.020
	disease of metabolism	DOID:0014667	0	0.020

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