IMP: Integrative Multi-species Prediction

Mus musculus

268 known processes

Erbb2

v-erb-b2 erythroblastic leukemia viral oncogene homolog 2, neuro/glioblastoma derived oncogene homolog (avian)

(Aliases: c-erbB2,HER-2,mKIAA3023,HER2,c-neu,Erbb-2,Neu)

Entrez: 13866
Ensembl: ENSMUSG00000062312
UniProtKB: P70424

Process Predictions
Disease Predictions

Erbb2 biological process predictions

Show only novel predictionsHighlight processes of functional analogs

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Biological process	GO term ID	Process size	Probability	Func Analog Org
axon guidance	GO:0007411	141	0.998
axonogenesis	GO:0007409	274	0.998
neuron projection guidance	GO:0097485	141	0.997
chemotaxis	GO:0006935	247	0.995
establishment or maintenance of bipolar cell polarity	GO:0061245	21	0.992	Fly
tyrosine phosphorylation of stat5 protein	GO:0042506	9	0.991	Mouse
stem cell development	GO:0048864	219	0.989	Zebrafish Mouse Fly
ameboidal type cell migration	GO:0001667	128	0.988	Zebrafish Mouse Fly
ovulation	GO:0030728	15	0.983	Worm
skeletal muscle organ development	GO:0060538	163	0.978	Rat
cranial nerve development	GO:0021545	41	0.975	Zebrafish Mouse
urogenital system development	GO:0001655	261	0.974	Fly
cell adhesion	GO:0007155	329	0.972	Human Fly
kidney development	GO:0001822	213	0.968
rho protein signal transduction	GO:0007266	32	0.966
positive regulation of heart growth	GO:0060421	18	0.961	Mouse
single organismal cell cell adhesion	GO:0016337	131	0.958	Fly
nephron epithelium morphogenesis	GO:0072088	68	0.957
t cell activation	GO:0042110	289	0.953
autonomic nervous system development	GO:0048483	43	0.951	Rat
guanosine containing compound catabolic process	GO:1901069	144	0.945
axon target recognition	GO:0007412	4	0.940
negative regulation of immature t cell proliferation	GO:0033087	3	0.936
pallium development	GO:0021543	120	0.933	Mouse
nerve development	GO:0021675	67	0.932	Zebrafish Mouse
camera type eye development	GO:0043010	266	0.923
kidney epithelium development	GO:0072073	121	0.923
mesenchymal cell development	GO:0014031	93	0.916	Zebrafish Mouse
negative regulation of ovulation	GO:0060280	1	0.915
intracellular protein transport	GO:0006886	204	0.909	Mouse
guanosine containing compound metabolic process	GO:1901068	144	0.908
neural crest cell migration	GO:0001755	32	0.908	Zebrafish Mouse
positive regulation of nervous system development	GO:0051962	221	0.906
morphogenesis of embryonic epithelium	GO:0016331	159	0.905	Fly
hindbrain development	GO:0030902	128	0.904
olfactory bulb interneuron differentiation	GO:0021889	12	0.904	Mouse
ras protein signal transduction	GO:0007265	77	0.900	Rat
digestive tract development	GO:0048565	190	0.898	Mouse Fly
wound healing	GO:0042060	157	0.895	Human Zebrafish Mouse Fly
motor neuron axon guidance	GO:0008045	26	0.894
negative regulation of nervous system development	GO:0051961	156	0.892
dendrite extension	GO:0097484	3	0.891
negative regulation of synapse assembly	GO:0051964	3	0.890
nephron morphogenesis	GO:0072028	69	0.890
oocyte axis specification	GO:0007309	2	0.889	Fly
digestive tract morphogenesis	GO:0048546	147	0.888	Mouse Fly
oocyte differentiation	GO:0009994	35	0.881	Fly
digestive system development	GO:0055123	200	0.874	Mouse Fly
olfactory lobe development	GO:0021988	32	0.873	Mouse
response to amino acid	GO:0043200	37	0.871	Mouse
epidermis development	GO:0008544	187	0.870	Mouse
mesenchyme development	GO:0060485	152	0.868	Zebrafish Mouse
purine ribonucleoside catabolic process	GO:0046130	205	0.864
positive regulation of neuron maturation	GO:0014042	2	0.857
glycosyl compound metabolic process	GO:1901657	246	0.855
negative regulation of cell proliferation	GO:0008285	296	0.855
epithelial tube morphogenesis	GO:0060562	303	0.854	Fly
nephron tubule morphogenesis	GO:0072078	68	0.853
ribonucleotide catabolic process	GO:0009261	208	0.851
sensory organ morphogenesis	GO:0090596	242	0.851	Fly
salivary gland morphogenesis	GO:0007435	33	0.850	Mouse
hair follicle development	GO:0001942	85	0.848	Mouse
regulation of rho protein signal transduction	GO:0035023	71	0.845
ureteric bud morphogenesis	GO:0060675	62	0.836
cell fate commitment	GO:0045165	210	0.832	Mouse Fly
retinal blood vessel morphogenesis	GO:0061304	3	0.829
stem cell differentiation	GO:0048863	268	0.822	Zebrafish Mouse Fly
protein localization to membrane	GO:0072657	108	0.814
central nervous system neuron differentiation	GO:0021953	162	0.813	Mouse
wnt signaling pathway	GO:0016055	188	0.809
regulation of neuron projection development	GO:0010975	169	0.808
mesonephric tubule morphogenesis	GO:0072171	63	0.808
regulation of epithelial cell proliferation	GO:0050678	141	0.806	Human Mouse
oocyte construction	GO:0007308	2	0.804	Fly
positive regulation of cell development	GO:0010720	237	0.803
peripheral nervous system development	GO:0007422	53	0.791
lymphocyte proliferation	GO:0046651	164	0.791
metencephalon development	GO:0022037	89	0.783
pigment metabolic process	GO:0042440	32	0.783
positive regulation of neuron differentiation	GO:0045666	141	0.782
purine nucleoside metabolic process	GO:0042278	241	0.781
rhombomere morphogenesis	GO:0021593	2	0.767
neuron projection extension	GO:1990138	64	0.766
negative regulation of cellular component organization	GO:0051129	194	0.763
preganglionic parasympathetic nervous system development	GO:0021783	17	0.760
endocardial cushion development	GO:0003197	26	0.759	Mouse
forebrain cell migration	GO:0021885	58	0.757	Mouse
neural crest cell differentiation	GO:0014033	54	0.756	Zebrafish Mouse
odontogenesis	GO:0042476	78	0.754
response to peptide hormone	GO:0043434	127	0.748
small gtpase mediated signal transduction	GO:0007264	97	0.745	Rat
extrinsic apoptotic signaling pathway	GO:0097191	126	0.745
glomerular epithelial cell development	GO:0072310	6	0.743
schwann cell development	GO:0014044	22	0.743	Zebrafish
establishment or maintenance of apical basal cell polarity	GO:0035088	21	0.733	Fly
mammary gland morphogenesis	GO:0060443	54	0.732	Rat
bmp signaling pathway	GO:0030509	93	0.731
mesenchymal cell differentiation	GO:0048762	107	0.729	Zebrafish Mouse
mammary gland epithelium development	GO:0061180	65	0.728	Mouse
gland development	GO:0048732	330	0.727	Mouse Rat Fly
regulation of neuron differentiation	GO:0045664	281	0.726
membrane organization	GO:0061024	245	0.726
neuron recognition	GO:0008038	25	0.725	Zebrafish
embryonic placenta development	GO:0001892	98	0.725	Mouse
regulation of gtp catabolic process	GO:0033124	113	0.721
positive regulation of cardiac muscle tissue growth	GO:0055023	15	0.721	Mouse
embryonic organ morphogenesis	GO:0048562	276	0.720
transmembrane receptor protein tyrosine kinase signaling pathway	GO:0007169	247	0.713	Human Mouse
purine nucleotide metabolic process	GO:0006163	302	0.712
purine containing compound catabolic process	GO:0072523	213	0.708
schwann cell differentiation	GO:0014037	26	0.706	Zebrafish Mouse
mesoderm formation	GO:0001707	62	0.705
epithelial tube formation	GO:0072175	130	0.703
regulation of t cell differentiation	GO:0045580	83	0.702
sensory perception	GO:0007600	245	0.700
cerebral cortex development	GO:0021987	86	0.695	Mouse
cardiac muscle tissue development	GO:0048738	130	0.694	Mouse
regulation of cytoskeleton organization	GO:0051493	122	0.692
positive regulation of rho gtpase activity	GO:0032321	41	0.692
establishment of protein localization to organelle	GO:0072594	118	0.690	Mouse
positive regulation of nucleotide catabolic process	GO:0030813	88	0.687
rhombomere 5 development	GO:0021571	4	0.681
morphogenesis of a polarized epithelium	GO:0001738	37	0.680	Fly
response to growth factor	GO:0070848	198	0.679
negative regulation of neuron differentiation	GO:0045665	101	0.678
multicellular organismal signaling	GO:0035637	91	0.676
neural crest cell development	GO:0014032	48	0.675	Zebrafish Mouse
cranial nerve morphogenesis	GO:0021602	26	0.673
pons development	GO:0021548	13	0.673
synaptic transmission	GO:0007268	329	0.668
t cell differentiation in thymus	GO:0033077	77	0.667
regulation of t cell activation	GO:0050863	170	0.665
cellular amino acid metabolic process	GO:0006520	103	0.662
negative regulation of t cell differentiation	GO:0045581	23	0.660
positive regulation of fibroblast proliferation	GO:0048146	20	0.656	Mouse
regulation of hydrolase activity	GO:0051336	246	0.653
rhombomere 3 morphogenesis	GO:0021658	2	0.652
cellular ketone metabolic process	GO:0042180	84	0.651
regulation of ras gtpase activity	GO:0032318	88	0.642
nephron tubule development	GO:0072080	84	0.641
regulation of mitotic cell cycle phase transition	GO:1901990	73	0.629	Fly
formation of radial glial scaffolds	GO:0021943	4	0.625
myelination	GO:0042552	74	0.624
embryonic skeletal system morphogenesis	GO:0048704	91	0.619
lateral line system development	GO:0048925	1	0.618	Zebrafish
positive regulation of intracellular transport	GO:0032388	70	0.618	Mouse
axonal fasciculation	GO:0007413	15	0.616	Zebrafish
parasympathetic nervous system development	GO:0048486	19	0.615
segmentation	GO:0035282	93	0.605	Fly
positive regulation of peptidyl tyrosine phosphorylation	GO:0050731	61	0.605	Mouse
response to organonitrogen compound	GO:0010243	246	0.603	Mouse
regulation of ovulation	GO:0060278	3	0.602
positive regulation of ras gtpase activity	GO:0032320	65	0.601
ribonucleoside metabolic process	GO:0009119	245	0.601
negative regulation of neuron projection development	GO:0010977	50	0.600
facial nerve morphogenesis	GO:0021610	11	0.598
negative regulation of epithelial cell proliferation	GO:0050680	64	0.596
regulation of lymphocyte proliferation	GO:0050670	117	0.595
cellular response to organonitrogen compound	GO:0071417	145	0.594	Mouse
nucleoside metabolic process	GO:0009116	246	0.591
protein localization to nucleus	GO:0034504	121	0.591	Mouse
neuron maturation	GO:0042551	29	0.591
positive regulation of intracellular protein transport	GO:0090316	42	0.584	Mouse
activation of transmembrane receptor protein tyrosine kinase activity	GO:0007171	3	0.582
ribonucleoside triphosphate catabolic process	GO:0009203	199	0.582
developmental maturation	GO:0021700	193	0.574	Fly
ear development	GO:0043583	200	0.571
cell junction organization	GO:0034330	77	0.571
brain segmentation	GO:0035284	3	0.570
secondary metabolic process	GO:0019748	18	0.570
placenta development	GO:0001890	140	0.570	Mouse
canonical wnt signaling pathway	GO:0060070	130	0.569
protein depolymerization	GO:0051261	34	0.566
regulation of cell motility	GO:2000145	236	0.566	Mouse
purine nucleotide catabolic process	GO:0006195	211	0.564
cilium assembly	GO:0042384	81	0.563
positive regulation of neuron projection development	GO:0010976	79	0.561
development of primary sexual characteristics	GO:0045137	143	0.561	Fly
metanephric nephron development	GO:0072210	34	0.560
nuclear transport	GO:0051169	139	0.557	Mouse
leukocyte proliferation	GO:0070661	172	0.557
leukocyte differentiation	GO:0002521	342	0.556
cell maturation	GO:0048469	127	0.555	Fly
negative regulation of wnt signaling pathway	GO:0030178	73	0.549
transmission of nerve impulse	GO:0019226	76	0.549
positive regulation of cellular amine metabolic process	GO:0033240	5	0.549
neuromuscular process	GO:0050905	99	0.548
regulation of axon extension	GO:0030516	43	0.547
regulation of wnt signaling pathway	GO:0030111	123	0.547
lymphocyte differentiation	GO:0030098	242	0.541
neuron neuron synaptic transmission	GO:0007270	69	0.536
positive regulation of gtp catabolic process	GO:0033126	85	0.536
morphogenesis of a branching epithelium	GO:0061138	193	0.535
organophosphate catabolic process	GO:0046434	232	0.532
regulation of muscle tissue development	GO:1901861	97	0.531	Mouse
hindbrain tangential cell migration	GO:0021934	2	0.531
neuronal action potential	GO:0019228	54	0.529
establishment or maintenance of cell polarity	GO:0007163	86	0.527	Fly
renal system development	GO:0072001	225	0.526	Fly
smoothened signaling pathway	GO:0007224	105	0.526
intermediate filament cytoskeleton organization	GO:0045104	26	0.524
stat protein import into nucleus	GO:0007262	6	0.516	Mouse
negative regulation of lymphocyte proliferation	GO:0050672	45	0.516
ribonucleoside catabolic process	GO:0042454	206	0.515
protein targeting	GO:0006605	143	0.514	Mouse
purine ribonucleotide catabolic process	GO:0009154	208	0.509
cerebral cortex cell migration	GO:0021795	44	0.504	Mouse
positive regulation of nucleoside metabolic process	GO:0045979	91	0.503
response to peptide	GO:1901652	136	0.502
skeletal muscle cell differentiation	GO:0035914	66	0.500
cellular nitrogen compound catabolic process	GO:0044270	280	0.499
nucleocytoplasmic transport	GO:0006913	139	0.496	Mouse
regulation of cell projection organization	GO:0031344	206	0.494
forebrain generation of neurons	GO:0021872	63	0.493	Mouse
positive regulation of apoptotic signaling pathway	GO:2001235	95	0.490
negative regulation of t cell proliferation	GO:0042130	38	0.489
regulation of cell size	GO:0008361	72	0.487
forebrain development	GO:0030900	302	0.487	Mouse
nucleoside triphosphate catabolic process	GO:0009143	205	0.486
regulation of organ morphogenesis	GO:2000027	144	0.484	Fly
stem cell fate commitment	GO:0048865	5	0.484	Fly
positive regulation of gtpase activity	GO:0043547	85	0.483
mammary gland lobule development	GO:0061377	22	0.480	Mouse
mammary gland involution	GO:0060056	9	0.480	Rat
regulation of stat protein import into nucleus	GO:2000364	2	0.476	Mouse
angiogenesis	GO:0001525	201	0.474
positive regulation of cytoplasmic transport	GO:1903651	40	0.474	Mouse
positive regulation of protein import into nucleus	GO:0042307	26	0.474	Mouse
epithelial cell proliferation	GO:0050673	174	0.474	Human Mouse Fly
ensheathment of neurons	GO:0007272	76	0.472
regulation of cell adhesion	GO:0030155	154	0.471	Human
regulation of cellular catabolic process	GO:0031329	242	0.470
cellular response to growth factor stimulus	GO:0071363	197	0.469
kidney morphogenesis	GO:0060993	83	0.468
rhombomere 3 development	GO:0021569	4	0.466
branching morphogenesis of an epithelial tube	GO:0048754	159	0.465
regulation of cell activation	GO:0050865	289	0.465
regulation of synaptic growth at neuromuscular junction	GO:0008582	4	0.465
regulation of intracellular protein transport	GO:0033157	82	0.464	Mouse
cell substrate adhesion	GO:0031589	130	0.463
establishment of planar polarity	GO:0001736	28	0.462	Fly
positive regulation of muscle tissue development	GO:1901863	32	0.455	Mouse
regulation of cell migration	GO:0030334	219	0.452	Mouse
amine metabolic process	GO:0009308	45	0.450
striated muscle tissue development	GO:0014706	293	0.449	Mouse Rat
regulation of ras protein signal transduction	GO:0046578	114	0.448
regulation of mapk cascade	GO:0043408	248	0.446	Human Rat
neural tube closure	GO:0001843	90	0.446
glucose import	GO:0046323	32	0.444
cell growth	GO:0016049	130	0.442	Human
skin development	GO:0043588	220	0.441	Mouse
regulation of glucose transport	GO:0010827	32	0.438
male sex differentiation	GO:0046661	109	0.437	Worm
rac protein signal transduction	GO:0016601	13	0.437
regulation of canonical wnt signaling pathway	GO:0060828	82	0.437
regulation of leukocyte proliferation	GO:0070663	121	0.431
cardiac muscle cell differentiation	GO:0055007	69	0.430
cellular protein complex disassembly	GO:0043624	36	0.429
embryonic epithelial tube formation	GO:0001838	130	0.424
negative regulation of mitotic cell cycle	GO:0045930	58	0.422	Fly
purine nucleoside triphosphate catabolic process	GO:0009146	203	0.421
regulation of intracellular transport	GO:0032386	159	0.419	Mouse
macromolecular complex disassembly	GO:0032984	43	0.418
telencephalon cell migration	GO:0022029	55	0.416	Mouse
response to insulin	GO:0032868	100	0.416
cardiocyte differentiation	GO:0035051	87	0.415
cilium morphogenesis	GO:0060271	102	0.415
positive regulation of cell projection organization	GO:0031346	95	0.414
regulation of cellular ketone metabolic process	GO:0010565	66	0.411
melanin metabolic process	GO:0006582	12	0.410
negative regulation of canonical wnt signaling pathway	GO:0090090	51	0.410
regulation of cellular amine metabolic process	GO:0033238	20	0.409
regulation of cellular amino acid metabolic process	GO:0006521	5	0.407
negative regulation of lymphocyte differentiation	GO:0045620	32	0.406
mapk cascade	GO:0000165	281	0.406	Human Rat
positive regulation of axon extension	GO:0045773	20	0.405
molting cycle	GO:0042303	90	0.404	Mouse
retina development in camera type eye	GO:0060041	119	0.403
regulation of cell morphogenesis involved in differentiation	GO:0010769	151	0.402
nerve growth factor signaling pathway	GO:0038180	3	0.401
neural tube formation	GO:0001841	108	0.400
renal tubule development	GO:0061326	87	0.398	Fly
purine nucleoside triphosphate metabolic process	GO:0009144	226	0.396
neural tube development	GO:0021915	160	0.391
negative regulation of cell activation	GO:0050866	111	0.391
regulation of heart growth	GO:0060420	31	0.390	Mouse
regulation of nucleocytoplasmic transport	GO:0046822	73	0.386	Mouse
extrinsic apoptotic signaling pathway in absence of ligand	GO:0097192	55	0.386
detection of external stimulus	GO:0009581	61	0.384
t cell proliferation	GO:0042098	120	0.379
rhombomere formation	GO:0021594	1	0.378
positive regulation of tyrosine phosphorylation of stat5 protein	GO:0042523	6	0.377	Mouse
single organism cell adhesion	GO:0098602	156	0.377	Fly
positive regulation of cellular amino acid metabolic process	GO:0045764	3	0.374
regulation of tyrosine phosphorylation of stat5 protein	GO:0042522	8	0.373	Mouse
regulation of lymphocyte differentiation	GO:0045619	107	0.373
response to fibroblast growth factor	GO:0071774	47	0.371
positive regulation of protein modification process	GO:0031401	299	0.370
cellular amine metabolic process	GO:0044106	44	0.368
circulatory system process	GO:0003013	197	0.368	Fly
mesoderm morphogenesis	GO:0048332	64	0.367
purine ribonucleoside triphosphate catabolic process	GO:0009207	199	0.366
regulation of t cell differentiation in thymus	GO:0033081	24	0.365
positive regulation of cellular catabolic process	GO:0031331	148	0.361
regulation of apoptotic signaling pathway	GO:2001233	197	0.360	Fly
gonad development	GO:0008406	141	0.355	Fly
facial nerve structural organization	GO:0021612	10	0.354
protein complex disassembly	GO:0043241	40	0.354
cellular response to fibroblast growth factor stimulus	GO:0044344	47	0.353
cell type specific apoptotic process	GO:0097285	268	0.352	Mouse
cell junction assembly	GO:0034329	52	0.352
developmental cell growth	GO:0048588	84	0.351
sensory system development	GO:0048880	3	0.350	Zebrafish
positive regulation of nucleocytoplasmic transport	GO:0046824	30	0.348	Mouse
nucleobase containing small molecule metabolic process	GO:0055086	352	0.348
positive regulation of tyrosine phosphorylation of stat protein	GO:0042531	15	0.347	Mouse
regulation of protein depolymerization	GO:1901879	26	0.346
synapse organization	GO:0050808	125	0.346
renal tubule morphogenesis	GO:0061333	72	0.344	Fly
regulation of protein serine threonine kinase activity	GO:0071900	157	0.343	Human
dendrite development	GO:0016358	115	0.341
asymmetric neuroblast division	GO:0055059	1	0.340
regulation of t cell proliferation	GO:0042129	92	0.339
ureteric bud development	GO:0001657	94	0.339
carbohydrate derivative catabolic process	GO:1901136	231	0.338
muscle cell differentiation	GO:0042692	261	0.337
establishment of protein localization to membrane	GO:0090150	54	0.333
genitalia development	GO:0048806	37	0.333	Worm
heart growth	GO:0060419	45	0.330	Mouse
axon regeneration	GO:0031103	12	0.329
epithelial cell morphogenesis	GO:0003382	41	0.325
nucleoside triphosphate metabolic process	GO:0009141	230	0.324
neural crest cell migration involved in autonomic nervous system development	GO:1901166	5	0.324
oviduct development	GO:0060066	3	0.321
peptidyl amino acid modification	GO:0018193	336	0.320	Human Mouse Rat
carbohydrate transport	GO:0008643	62	0.320
morphogenesis of a branching structure	GO:0001763	203	0.318
t cell differentiation	GO:0030217	174	0.317
negative regulation of cell cycle	GO:0045786	123	0.317	Fly
negative regulation of mitotic cell cycle phase transition	GO:1901991	45	0.316	Fly
adrenal cortex formation	GO:0035802	2	0.314
negative regulation of t cell activation	GO:0050868	65	0.314
stem cell maintenance	GO:0019827	130	0.314	Fly
olfactory learning	GO:0008355	2	0.313	Fly
nephron development	GO:0072006	109	0.312
ribonucleoside triphosphate metabolic process	GO:0009199	220	0.311
hindbrain morphogenesis	GO:0021575	46	0.311
oocyte development	GO:0048599	33	0.311	Fly
cognition	GO:0050890	149	0.309	Fly
purine ribonucleoside triphosphate metabolic process	GO:0009205	220	0.308
regulation of cardiac muscle tissue development	GO:0055024	31	0.308	Mouse
sympathetic nervous system development	GO:0048485	22	0.307	Rat
mechanoreceptor differentiation	GO:0042490	67	0.306
olfactory bulb development	GO:0021772	30	0.305	Mouse
regulation of g1 s transition of mitotic cell cycle	GO:2000045	35	0.303	Fly
rhombomere development	GO:0021546	8	0.301
regulation of protein complex disassembly	GO:0043244	28	0.300
hexose transport	GO:0008645	56	0.299
regulation of protein tyrosine kinase activity	GO:0061097	17	0.298
negative regulation of leukocyte differentiation	GO:1902106	51	0.297
blood vessel morphogenesis	GO:0048514	285	0.296
protein localization to organelle	GO:0033365	185	0.295	Mouse
regulation of protein import into nucleus	GO:0042306	52	0.293	Mouse
striated muscle cell proliferation	GO:0014855	39	0.292	Mouse
regulation of neuron apoptotic process	GO:0043523	122	0.292	Mouse
purine ribonucleoside metabolic process	GO:0046128	241	0.291
response to acid chemical	GO:0001101	111	0.290	Mouse
regulation of extent of cell growth	GO:0061387	52	0.289
negative regulation of dendritic spine morphogenesis	GO:0061002	3	0.289
female meiosis chromosome segregation	GO:0016321	1	0.288
endocardial cell differentiation	GO:0060956	4	0.286
lateral line nerve development	GO:0048892	1	0.283	Zebrafish
regulation of tyrosine phosphorylation of stat protein	GO:0042509	20	0.282	Mouse
positive regulation of protein transport	GO:0051222	93	0.281	Mouse
female gamete generation	GO:0007292	74	0.277	Worm Fly
embryonic skeletal system development	GO:0048706	120	0.276
regulation of stem cell proliferation	GO:0072091	78	0.272
positive regulation of purine nucleotide catabolic process	GO:0033123	88	0.272
regulation of establishment of protein localization	GO:0070201	181	0.270	Mouse
positive regulation of wnt signaling pathway	GO:0030177	45	0.270
protein import into nucleus	GO:0006606	95	0.269	Mouse
muscle tissue development	GO:0060537	308	0.265	Mouse Rat
cranial nerve structural organization	GO:0021604	13	0.265
mesenchyme morphogenesis	GO:0072132	32	0.265
formation of primary germ layer	GO:0001704	77	0.263
signal transduction in absence of ligand	GO:0038034	55	0.262
positive regulation of hydrolase activity	GO:0051345	148	0.261
positive regulation of neuron death	GO:1901216	28	0.261
regionalization	GO:0003002	337	0.261	Fly
glial cell fate determination	GO:0007403	3	0.260
nucleoside phosphate metabolic process	GO:0006753	338	0.258
endocytosis	GO:0006897	168	0.257
regulation of kinase activity	GO:0043549	249	0.257	Human
learning or memory	GO:0007611	148	0.256	Fly
regulation of jak stat cascade	GO:0046425	34	0.254	Mouse
forebrain neuron differentiation	GO:0021879	52	0.254	Mouse
notochord formation	GO:0014028	5	0.254
negative regulation of protein depolymerization	GO:1901880	21	0.252
positive regulation of cardiac muscle tissue development	GO:0055025	19	0.249	Mouse
oligodendrocyte differentiation	GO:0048709	53	0.247
regulation of fibroblast proliferation	GO:0048145	34	0.247	Mouse
cellular response to transforming growth factor beta stimulus	GO:0071560	88	0.243
negative regulation of g1 s transition of mitotic cell cycle	GO:2000134	18	0.241	Fly
adrenal cortex development	GO:0035801	2	0.239
regulation of purine nucleotide catabolic process	GO:0033121	122	0.239
limbic system development	GO:0021761	72	0.238
immature t cell proliferation in thymus	GO:0033080	7	0.238
monosaccharide transport	GO:0015749	58	0.237
jak stat cascade	GO:0007259	42	0.236	Mouse
mammary gland alveolus development	GO:0060749	22	0.236	Mouse
zygotic determination of anterior posterior axis embryo	GO:0007354	3	0.236
mesonephric epithelium development	GO:0072163	94	0.236
neuron apoptotic process	GO:0051402	142	0.233	Mouse
positive regulation of epithelial cell proliferation	GO:0050679	68	0.233	Human Mouse
nephron epithelium development	GO:0072009	92	0.232
fibroblast growth factor receptor signaling pathway	GO:0008543	46	0.229
glucose transport	GO:0015758	56	0.227
regulation of organ growth	GO:0046620	61	0.225	Mouse
pharynx development	GO:0060465	1	0.225
central nervous system segmentation	GO:0035283	3	0.223
metanephric glomerular mesangial cell proliferation involved in metanephros development	GO:0072262	3	0.222
female gonad development	GO:0008585	71	0.222
regulation of peptidyl tyrosine phosphorylation	GO:0050730	93	0.222	Mouse
formation of anatomical boundary	GO:0048859	6	0.221
divalent inorganic cation homeostasis	GO:0072507	138	0.221
cellular response to acid chemical	GO:0071229	68	0.220	Mouse
regulation of dendritic spine development	GO:0060998	22	0.220
lactation	GO:0007595	25	0.216	Mouse
protein import	GO:0017038	101	0.215	Mouse
mesenchymal to epithelial transition	GO:0060231	12	0.215
positive regulation of mapk cascade	GO:0043410	170	0.215	Human Rat
formation of organ boundary	GO:0010160	1	0.214
developmental pigmentation	GO:0048066	40	0.214
regulation of hippo signaling	GO:0035330	1	0.213
gliogenesis	GO:0042063	141	0.213
nucleotide catabolic process	GO:0009166	217	0.212
cardiac muscle cell proliferation	GO:0060038	31	0.212	Mouse
stem cell proliferation	GO:0072089	117	0.211
regulation of membrane potential	GO:0042391	192	0.208
negative regulation of cell cycle phase transition	GO:1901988	48	0.208	Fly
organelle assembly	GO:0070925	177	0.207
metanephric part of ureteric bud development	GO:0035502	2	0.207
regulation of immature t cell proliferation in thymus	GO:0033084	6	0.206
regulation of cellular component size	GO:0032535	121	0.205
negative regulation of cell projection organization	GO:0031345	56	0.205
mitotic cell cycle	GO:0000278	195	0.204	Fly
gastrulation	GO:0007369	116	0.204
negative regulation of protein metabolic process	GO:0051248	282	0.203
positive regulation of glucose import	GO:0046326	14	0.203
apoptotic signaling pathway	GO:0097190	306	0.203	Fly
compound eye development	GO:0048749	1	0.202	Fly
glial cell differentiation	GO:0010001	131	0.202
action potential	GO:0001508	78	0.201
microtubule polymerization or depolymerization	GO:0031109	26	0.201
neuron migration	GO:0001764	122	0.201
transmembrane receptor protein serine threonine kinase signaling pathway	GO:0007178	194	0.200
hair cycle	GO:0042633	90	0.198	Mouse
muscle cell proliferation	GO:0033002	52	0.198	Mouse
telencephalon development	GO:0021537	186	0.198	Mouse
regulation of protein kinase activity	GO:0045859	232	0.195	Human
peptidyl tyrosine modification	GO:0018212	145	0.194	Human Mouse Rat
branching involved in mammary gland duct morphogenesis	GO:0060444	27	0.194
metanephric comma shaped body morphogenesis	GO:0072278	1	0.193
ribose phosphate metabolic process	GO:0019693	291	0.193
purine containing compound metabolic process	GO:0072521	311	0.192
regulation of immature t cell proliferation	GO:0033083	7	0.192
brain morphogenesis	GO:0048854	32	0.190
regulation of actin cytoskeleton organization	GO:0032956	84	0.189
morphogenesis of an epithelial sheet	GO:0002011	27	0.189
cellular component assembly involved in morphogenesis	GO:0010927	139	0.187	Fly
synapse assembly	GO:0007416	56	0.187
regulation of mitotic cell cycle	GO:0007346	126	0.187	Fly
positive regulation of striated muscle tissue development	GO:0045844	31	0.186	Mouse
protein localization to plasma membrane	GO:0072659	57	0.185
regulation of extrinsic apoptotic signaling pathway	GO:2001236	77	0.184
nucleoside catabolic process	GO:0009164	206	0.183
regulation of wound healing	GO:0061041	40	0.183	Fly
epidermal growth factor receptor signaling pathway	GO:0007173	28	0.183	Mouse
focal adhesion assembly	GO:0048041	19	0.182
regulation of synapse assembly	GO:0051963	29	0.182
postganglionic parasympathetic nervous system development	GO:0021784	2	0.181
ephrin receptor signaling pathway	GO:0048013	20	0.181
nuclear import	GO:0051170	95	0.181	Mouse
primary neural tube formation	GO:0014020	95	0.180
pigmentation	GO:0043473	71	0.180
regulation of protein transport	GO:0051223	163	0.180	Mouse
cardiac muscle tissue growth	GO:0055017	37	0.179	Mouse
gamma delta t cell differentiation	GO:0042492	11	0.178
regulation of cell cycle phase transition	GO:1901987	77	0.178	Fly
exocrine system development	GO:0035272	45	0.177	Mouse Fly

Erbb2 disease predictions

Disease predictions are made from cross-annotation of human disease genes to the identified functional analogs in mouse and predicted with the mouse functional network.

Disease	DO term ID	Probability
heart disease	DOID:114	0.317
disease of anatomical entity	DOID:7	0.317
cardiovascular system disease	DOID:1287	0.317
neuromuscular disease	DOID:440	0.251
charcot marie tooth disease	DOID:10595	0.251
nervous system disease	DOID:863	0.251
neuropathy	DOID:870	0.251

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