IMP: Integrative Multi-species Prediction

Mus musculus

288 known processes

Erbb4

v-erb-a erythroblastic leukemia viral oncogene homolog 4 (avian)

(Aliases: c-erbB-4,Her4)

Ensembl: ENSMUSG00000062209
Entrez: 13869
UniProtKB: Q61527

Process Predictions
Disease Predictions

Erbb4 biological process predictions

Show only novel predictionsHighlight processes of functional analogs

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Biological process	GO term ID	Process size	Probability	Func Analog Org
regulation of cellular ketone metabolic process	GO:0010565	66	0.913
positive regulation of kinase activity	GO:0033674	155	0.731	Human
cell adhesion	GO:0007155	329	0.704	Fly
ear development	GO:0043583	200	0.693
regulation of cellular amine metabolic process	GO:0033238	20	0.648
chemotaxis	GO:0006935	247	0.602	Mouse
positive regulation of cellular amine metabolic process	GO:0033240	5	0.599
cellular amine metabolic process	GO:0044106	44	0.582
nerve development	GO:0021675	67	0.564	Mouse
embryonic organ morphogenesis	GO:0048562	276	0.548
limbic system development	GO:0021761	72	0.531
cellular amino acid metabolic process	GO:0006520	103	0.530
mapk cascade	GO:0000165	281	0.522	Human
heart morphogenesis	GO:0003007	178	0.518
response to growth factor	GO:0070848	198	0.505
forebrain development	GO:0030900	302	0.502
regulation of cell migration	GO:0030334	219	0.496
regulation of membrane potential	GO:0042391	192	0.476	Mouse
positive regulation of protein phosphorylation	GO:0001934	242	0.468
striated muscle tissue development	GO:0014706	293	0.466
amine metabolic process	GO:0009308	45	0.465
heterocycle catabolic process	GO:0046700	280	0.464	Mouse
peptidyl tyrosine phosphorylation	GO:0018108	143	0.444
neuronal action potential	GO:0019228	54	0.429	Mouse
peptidyl tyrosine modification	GO:0018212	145	0.426
positive regulation of cellular amino acid metabolic process	GO:0045764	3	0.426
cardiac chamber morphogenesis	GO:0003206	93	0.423
regulation of transferase activity	GO:0051338	263	0.403	Human
stem cell differentiation	GO:0048863	268	0.386
cellular ketone metabolic process	GO:0042180	84	0.375
cellular nitrogen compound catabolic process	GO:0044270	280	0.374	Mouse
male sex differentiation	GO:0046661	109	0.369	Worm
glial cell differentiation	GO:0010001	131	0.349	Mouse
regulation of cellular amino acid metabolic process	GO:0006521	5	0.332
ribonucleoside triphosphate catabolic process	GO:0009203	199	0.328	Mouse
regulation of neuron differentiation	GO:0045664	281	0.326
determination of left right symmetry	GO:0007368	80	0.323
sensory organ morphogenesis	GO:0090596	242	0.311	Fly
cognition	GO:0050890	149	0.310	Fly
angiogenesis	GO:0001525	201	0.305
thyroid stimulating hormone secreting cell differentiation	GO:0060129	4	0.301
response to organic cyclic compound	GO:0014070	198	0.294	Rat
regulation of peptidyl tyrosine phosphorylation	GO:0050730	93	0.279
adult behavior	GO:0030534	135	0.279	Fly
positive regulation of gtp catabolic process	GO:0033126	85	0.276	Mouse
gland development	GO:0048732	330	0.273
cellular response to growth factor stimulus	GO:0071363	197	0.271
regulation of protein transport	GO:0051223	163	0.266
central nervous system neuron differentiation	GO:0021953	162	0.257
skeletal system development	GO:0001501	356	0.255
glial cell development	GO:0021782	54	0.254
blood vessel morphogenesis	GO:0048514	285	0.252
pallium development	GO:0021543	120	0.252	Mouse
cardiac chamber development	GO:0003205	108	0.250
mesenchyme development	GO:0060485	152	0.247
nucleotide catabolic process	GO:0009166	217	0.245	Mouse
ameboidal type cell migration	GO:0001667	128	0.242
synaptic transmission	GO:0007268	329	0.240	Rat
positive regulation of cardiac muscle cell proliferation	GO:0060045	15	0.240
regulation of hydrolase activity	GO:0051336	246	0.239	Mouse
positive regulation of striated muscle tissue development	GO:0045844	31	0.237
ear morphogenesis	GO:0042471	118	0.237
regulation of neuron projection development	GO:0010975	169	0.235
cardiac muscle tissue morphogenesis	GO:0055008	44	0.233
cell fate commitment	GO:0045165	210	0.231
muscle tissue development	GO:0060537	308	0.229
cardiac ventricle development	GO:0003231	83	0.226
lymphocyte differentiation	GO:0030098	242	0.226	Mouse
regionalization	GO:0003002	337	0.225	Fly
atrial ventricular junction remodeling	GO:0003294	2	0.225
gliogenesis	GO:0042063	141	0.220	Mouse
av node cell to bundle of his cell communication	GO:0086067	2	0.218
sensory perception of sound	GO:0007605	97	0.215
regulation of organ morphogenesis	GO:2000027	144	0.215	Fly
positive regulation of protein kinase activity	GO:0045860	144	0.213
carbohydrate metabolic process	GO:0005975	230	0.213
peptidyl amino acid modification	GO:0018193	336	0.213
blood circulation	GO:0008015	195	0.212
epithelial tube morphogenesis	GO:0060562	303	0.212	Fly
apoptotic signaling pathway	GO:0097190	306	0.211	Fly
segmentation	GO:0035282	93	0.210	Fly
associative learning	GO:0008306	61	0.208	Fly
transmission of nerve impulse	GO:0019226	76	0.207	Mouse
neuromuscular process	GO:0050905	99	0.205
ribonucleotide catabolic process	GO:0009261	208	0.199	Mouse
mesenchymal cell development	GO:0014031	93	0.198
positive regulation of protein modification process	GO:0031401	299	0.196
tissue remodeling	GO:0048771	102	0.194
neural crest cell development	GO:0014032	48	0.192
small gtpase mediated signal transduction	GO:0007264	97	0.190
single fertilization	GO:0007338	82	0.187
stem cell development	GO:0048864	219	0.187
hindbrain development	GO:0030902	128	0.186
regulation of organelle organization	GO:0033043	289	0.185
ventricular septum morphogenesis	GO:0060412	27	0.183
regulation of cardiac muscle tissue development	GO:0055024	31	0.182
regulation of kinase activity	GO:0043549	249	0.174	Human
heart process	GO:0003015	94	0.173	Fly
cell type specific apoptotic process	GO:0097285	268	0.172	Mouse Rat
camera type eye development	GO:0043010	266	0.170
organic cyclic compound catabolic process	GO:1901361	295	0.170	Mouse
response to light stimulus	GO:0009416	135	0.169
regulation of cardiac muscle cell proliferation	GO:0060043	23	0.167
regulation of cell projection organization	GO:0031344	206	0.165
positive regulation of mapk cascade	GO:0043410	170	0.165	Human
purine ribonucleoside triphosphate catabolic process	GO:0009207	199	0.164	Mouse
regulation of protein kinase activity	GO:0045859	232	0.163
protein secretion	GO:0009306	111	0.160
regulation of cell size	GO:0008361	72	0.160
central nervous system morphogenesis	GO:0021551	2	0.160
bone development	GO:0060348	120	0.160
forebrain neuron differentiation	GO:0021879	52	0.159
positive regulation of nervous system development	GO:0051962	221	0.159
cellular response to transforming growth factor beta stimulus	GO:0071560	88	0.156
anatomical structure homeostasis	GO:0060249	145	0.155	Rat Fly
regulation of secretion	GO:0051046	274	0.155
cellular chemical homeostasis	GO:0055082	215	0.155
regulation of cell growth	GO:0001558	91	0.154
protein import into nucleus	GO:0006606	95	0.152
fat cell differentiation	GO:0045444	160	0.150
protein localization to membrane	GO:0072657	108	0.150
cerebellum development	GO:0021549	77	0.149
ribonucleoside catabolic process	GO:0042454	206	0.149	Mouse
wnt signaling pathway	GO:0016055	188	0.149
hippocampus development	GO:0021766	52	0.148
inorganic ion transmembrane transport	GO:0098660	234	0.147
muscle contraction	GO:0006936	101	0.146
purine ribonucleoside catabolic process	GO:0046130	205	0.146	Mouse
branching involved in mammary gland duct morphogenesis	GO:0060444	27	0.145
positive regulation of transferase activity	GO:0051347	167	0.145	Human
positive regulation of peptidyl tyrosine phosphorylation	GO:0050731	61	0.144
limb development	GO:0060173	166	0.144
regulation of action potential	GO:0098900	4	0.143
digestive tract morphogenesis	GO:0048546	147	0.143	Mouse Fly
neural tube development	GO:0021915	160	0.142
carbohydrate derivative catabolic process	GO:1901136	231	0.142	Mouse
purine ribonucleotide catabolic process	GO:0009154	208	0.142	Mouse
neural crest cell migration	GO:0001755	32	0.141
brain segmentation	GO:0035284	3	0.140
nuclear transport	GO:0051169	139	0.138
sensory perception of mechanical stimulus	GO:0050954	107	0.137
cardiac muscle cell contraction	GO:0086003	7	0.137
regulation of cellular catabolic process	GO:0031329	242	0.137	Mouse
regulation of body fluid levels	GO:0050878	162	0.137
respiratory system development	GO:0060541	190	0.136	Fly
skeletal muscle organ development	GO:0060538	163	0.136
regulation of cell adhesion	GO:0030155	154	0.135
learning	GO:0007612	98	0.135	Fly
cation transmembrane transport	GO:0098655	266	0.134
telencephalon cell migration	GO:0022029	55	0.134	Mouse
axon guidance	GO:0007411	141	0.133	Mouse
negative regulation of neuron projection development	GO:0010977	50	0.131
regulation of cell morphogenesis involved in differentiation	GO:0010769	151	0.130
cellular response to organic cyclic compound	GO:0071407	87	0.128
regulation of cardiac muscle tissue growth	GO:0055021	26	0.127
meiotic cell cycle	GO:0051321	122	0.127
positive regulation of cell migration	GO:0030335	109	0.127	Rat
fertilization	GO:0009566	127	0.127
regulation of cell cycle	GO:0051726	281	0.126	Fly
regulation of cell motility	GO:2000145	236	0.125
olfactory bulb development	GO:0021772	30	0.125
cellular homeostasis	GO:0019725	240	0.125
embryonic heart tube morphogenesis	GO:0003143	51	0.125
ribose phosphate metabolic process	GO:0019693	291	0.124	Mouse
mechanoreceptor differentiation	GO:0042490	67	0.124
canonical wnt signaling pathway	GO:0060070	130	0.122
metal ion homeostasis	GO:0055065	189	0.121
positive regulation of protein serine threonine kinase activity	GO:0071902	106	0.120
muscle system process	GO:0003012	141	0.119
positive regulation of cell development	GO:0010720	237	0.118
synapse assembly	GO:0007416	56	0.118
planar cell polarity pathway involved in cardiac right atrium morphogenesis	GO:0061349	2	0.117
epidermis development	GO:0008544	187	0.117	Mouse
positive regulation of heart rate by epinephrine norepinephrine	GO:0001996	4	0.116
regulation of protein serine threonine kinase activity	GO:0071900	157	0.116
cellular carbohydrate metabolic process	GO:0044262	119	0.116
canonical wnt signaling pathway involved in regulation of cell proliferation	GO:0044340	3	0.116
purine nucleotide catabolic process	GO:0006195	211	0.115	Mouse
cell maturation	GO:0048469	127	0.113	Fly
embryonic limb morphogenesis	GO:0030326	126	0.113
regulation of reproductive process	GO:2000241	66	0.113
nuclear import	GO:0051170	95	0.112
foramen ovale closure	GO:0035922	1	0.112
purine nucleoside metabolic process	GO:0042278	241	0.112	Mouse
muscle tissue morphogenesis	GO:0060415	53	0.111
regulation of mapk cascade	GO:0043408	248	0.110	Human
ventricular septum development	GO:0003281	42	0.109
mitotic cell cycle process	GO:1903047	159	0.109	Fly
regulation of purine nucleotide catabolic process	GO:0033121	122	0.109	Mouse
negative regulation of nervous system development	GO:0051961	156	0.108
myelination	GO:0042552	74	0.108	Mouse
endomembrane system organization	GO:0010256	147	0.108
purine containing compound catabolic process	GO:0072523	213	0.108	Mouse
single organismal cell cell adhesion	GO:0016337	131	0.107	Fly
cardiac muscle cell differentiation	GO:0055007	69	0.107
leukocyte differentiation	GO:0002521	342	0.107	Mouse
response to organonitrogen compound	GO:0010243	246	0.106	Mouse
negative regulation of apoptotic signaling pathway	GO:2001234	104	0.106	Fly
sa node cell action potential	GO:0086015	4	0.106
positive regulation of cardiac muscle tissue development	GO:0055025	19	0.105
purine nucleoside triphosphate metabolic process	GO:0009144	226	0.105	Mouse
planar cell polarity pathway involved in outflow tract morphogenesis	GO:0061347	2	0.104
positive regulation of organ growth	GO:0046622	29	0.104
action potential	GO:0001508	78	0.104	Mouse
neuron projection guidance	GO:0097485	141	0.103	Mouse
developmental growth involved in morphogenesis	GO:0060560	138	0.103
positive regulation of muscle tissue development	GO:1901863	32	0.102
axis elongation involved in somitogenesis	GO:0090245	4	0.101
aromatic compound catabolic process	GO:0019439	286	0.101	Mouse
protein targeting	GO:0006605	143	0.101
negative regulation of cell projection organization	GO:0031345	56	0.100
telencephalon development	GO:0021537	186	0.099
epithelial cell proliferation	GO:0050673	174	0.098	Mouse Rat Fly
embryonic epithelial tube formation	GO:0001838	130	0.098
ribonucleoside metabolic process	GO:0009119	245	0.098	Mouse
regulation of muscle tissue development	GO:1901861	97	0.098
lung development	GO:0030324	164	0.097
positive regulation of epithelial cell proliferation	GO:0050679	68	0.097	Mouse Rat
nucleoside phosphate metabolic process	GO:0006753	338	0.097	Mouse
establishment of protein localization to organelle	GO:0072594	118	0.097
kidney development	GO:0001822	213	0.097
mammary gland epithelium development	GO:0061180	65	0.096
mesenchymal cell differentiation	GO:0048762	107	0.096
small molecule biosynthetic process	GO:0044283	132	0.096
digestive tract development	GO:0048565	190	0.096	Mouse Fly
gtp metabolic process	GO:0046039	144	0.096	Mouse
cardiac ventricle morphogenesis	GO:0003208	50	0.096
odontogenesis of dentin containing tooth	GO:0042475	66	0.096
guanosine containing compound catabolic process	GO:1901069	144	0.096	Mouse
cardiac muscle tissue growth	GO:0055017	37	0.095
metencephalon development	GO:0022037	89	0.095
morphogenesis of a branching epithelium	GO:0061138	193	0.095
cardiocyte differentiation	GO:0035051	87	0.094
planar cell polarity pathway involved in cardiac muscle tissue morphogenesis	GO:0061350	2	0.093
multi multicellular organism process	GO:0044706	109	0.093
regulation of transmembrane receptor protein serine threonine kinase signaling pathway	GO:0090092	112	0.092
vasodilation by norepinephrine epinephrine involved in regulation of systemic arterial blood pressure	GO:0002025	3	0.090
muscle cell differentiation	GO:0042692	261	0.090
sa node cell to atrial cardiac muscle cell signalling	GO:0086018	4	0.090
nucleocytoplasmic transport	GO:0006913	139	0.090
cellular response to organonitrogen compound	GO:0071417	145	0.090	Mouse
positive regulation of cardiac muscle tissue growth	GO:0055023	15	0.090
neuron projection extension	GO:1990138	64	0.090
g protein coupled receptor internalization	GO:0002031	3	0.089
t cell differentiation	GO:0030217	174	0.089	Mouse
multicellular organismal signaling	GO:0035637	91	0.089	Mouse
establishment of planar polarity involved in neural tube closure	GO:0090177	15	0.089
cochlea development	GO:0090102	35	0.088
wnt signaling pathway involved in forebrain neuroblast division	GO:0021874	2	0.088
appendage morphogenesis	GO:0035107	149	0.087	Fly
organelle fission	GO:0048285	170	0.087	Human
regulation of fat cell differentiation	GO:0045598	81	0.086
positive regulation of ras gtpase activity	GO:0032320	65	0.086	Mouse
central nervous system segmentation	GO:0035283	3	0.086
negative regulation of cell development	GO:0010721	169	0.086	Fly
ventricular cardiac muscle cell action potential	GO:0086005	4	0.085
diencephalon development	GO:0021536	63	0.085
regulation of protein localization	GO:0032880	231	0.085
amide transport	GO:0042886	138	0.085
cell fate specification	GO:0001708	72	0.085	Fly
oocyte construction	GO:0007308	2	0.084	Fly
regulation of antimicrobial humoral response	GO:0002759	3	0.084
regulation of ras gtpase activity	GO:0032318	88	0.084	Mouse
milk ejection	GO:0060156	1	0.083
cranial nerve development	GO:0021545	41	0.083	Mouse
smoothened signaling pathway	GO:0007224	105	0.083
positive regulation of heart growth	GO:0060421	18	0.082
regulation of cellular response to stress	GO:0080135	159	0.082
placenta development	GO:0001890	140	0.082	Mouse
histamine induced gastric acid secretion	GO:0001697	1	0.081
protein localization to organelle	GO:0033365	185	0.081
wnt signaling pathway calcium modulating pathway	GO:0007223	2	0.081
calcium ion dependent exocytosis	GO:0017156	35	0.081
germ cell development	GO:0007281	185	0.080	Fly
regulation of cell substrate adhesion	GO:0010810	73	0.080
neural crest cell differentiation	GO:0014033	54	0.080
regulation of nucleoside metabolic process	GO:0009118	130	0.080	Mouse
organ growth	GO:0035265	117	0.080
negative regulation of cell motility	GO:2000146	61	0.080
positive regulation of cell projection organization	GO:0031346	95	0.079
cardiac muscle tissue development	GO:0048738	130	0.079
embryonic appendage morphogenesis	GO:0035113	126	0.078
urogenital system development	GO:0001655	261	0.078	Fly
cellular response to lipid	GO:0071396	145	0.078
regulation of ras protein signal transduction	GO:0046578	114	0.077	Mouse
regulation of cellular carbohydrate metabolic process	GO:0010675	75	0.077
carbohydrate biosynthetic process	GO:0016051	74	0.077
regulation of systemic arterial blood pressure	GO:0003073	61	0.077
ossification	GO:0001503	216	0.077
regulation of mitotic cell cycle	GO:0007346	126	0.077	Fly
planar cell polarity pathway involved in pericardium morphogenesis	GO:0061354	2	0.077
appendage development	GO:0048736	166	0.077	Fly
purine containing compound metabolic process	GO:0072521	311	0.076	Mouse
striated muscle contraction	GO:0006941	45	0.076
protein catabolic process	GO:0030163	221	0.075
olfactory bulb interneuron differentiation	GO:0021889	12	0.075
protein import	GO:0017038	101	0.075
macromolecule catabolic process	GO:0009057	281	0.075
limb morphogenesis	GO:0035108	149	0.075
mammary gland duct morphogenesis	GO:0060603	38	0.074
positive regulation of the force of heart contraction by chemical signal	GO:0003099	3	0.074
epithelial cell morphogenesis	GO:0003382	41	0.074
negative regulation of growth	GO:0045926	99	0.074
single organism cell adhesion	GO:0098602	156	0.074	Fly
neuron migration	GO:0001764	122	0.074
regulation of establishment of protein localization	GO:0070201	181	0.074
cell growth	GO:0016049	130	0.074
nucleoside phosphate catabolic process	GO:1901292	222	0.074	Mouse
mammary gland morphogenesis	GO:0060443	54	0.074
positive regulation of map kinase activity	GO:0043406	84	0.073
forebrain generation of neurons	GO:0021872	63	0.072
positive regulation of cellular catabolic process	GO:0031331	148	0.072	Mouse
negative regulation of neuron differentiation	GO:0045665	101	0.072
response to transforming growth factor beta	GO:0071559	88	0.072
morphogenesis of an epithelial sheet	GO:0002011	27	0.071
regulation of gtp catabolic process	GO:0033124	113	0.071	Mouse
neuron apoptotic process	GO:0051402	142	0.070	Mouse
ventricular cardiac myofibril assembly	GO:0055005	3	0.070
regulation of nucleotide catabolic process	GO:0030811	122	0.069	Mouse
respiratory tube development	GO:0030323	167	0.069
sensory system development	GO:0048880	3	0.069
forebrain neuron development	GO:0021884	30	0.068
regulation of neuron death	GO:1901214	134	0.068	Mouse
regulation of establishment of planar polarity	GO:0090175	28	0.067
cation transport	GO:0006812	399	0.067
circulatory system process	GO:0003013	197	0.067	Fly
transmembrane receptor protein serine threonine kinase signaling pathway	GO:0007178	194	0.067
hexose metabolic process	GO:0019318	98	0.066
intracellular protein transport	GO:0006886	204	0.066
transmembrane receptor protein tyrosine kinase signaling pathway	GO:0007169	247	0.065	Human Mouse
embryonic placenta development	GO:0001892	98	0.065	Mouse
positive regulation of the force of heart contraction by epinephrine norepinephrine	GO:0001997	3	0.065
negative regulation of cell proliferation	GO:0008285	296	0.065	Human Mouse
development of primary sexual characteristics	GO:0045137	143	0.065	Fly
nucleoside metabolic process	GO:0009116	246	0.064	Mouse
kidney epithelium development	GO:0072073	121	0.064
establishment of protein localization to membrane	GO:0090150	54	0.064
cerebral cortex development	GO:0021987	86	0.064	Mouse
female gamete generation	GO:0007292	74	0.064	Worm Fly
heart contraction	GO:0060047	93	0.063
olfactory lobe development	GO:0021988	32	0.063
lipid biosynthetic process	GO:0008610	179	0.063
peptide hormone secretion	GO:0030072	109	0.063
epithelial cell development	GO:0002064	159	0.062	Fly
central nervous system neuron development	GO:0021954	67	0.062
purine ribonucleotide metabolic process	GO:0009150	290	0.062	Mouse
negative regulation of transforming growth factor beta receptor signaling pathway	GO:0030512	26	0.062
epithelial tube formation	GO:0072175	130	0.062
embryonic skeletal system morphogenesis	GO:0048704	91	0.062
skeletal muscle cell differentiation	GO:0035914	66	0.062
positive regulation of stem cell proliferation	GO:2000648	59	0.062
testosterone biosynthetic process	GO:0061370	2	0.061
muscle cell development	GO:0055001	133	0.061
ribonucleotide metabolic process	GO:0009259	291	0.061	Mouse
regulation of wnt signaling pathway	GO:0030111	123	0.061
regulation of carbohydrate metabolic process	GO:0006109	75	0.061
retina development in camera type eye	GO:0060041	119	0.061
positive regulation of carbohydrate metabolic process	GO:0045913	30	0.060
positive regulation of protein tyrosine kinase activity	GO:0061098	10	0.060
negative regulation of hormone metabolic process	GO:0032351	4	0.060
neuron death	GO:0070997	154	0.060	Mouse
oviduct development	GO:0060066	3	0.060
biomineral tissue development	GO:0031214	64	0.060
fear response	GO:0042596	33	0.060
cellular amide metabolic process	GO:0043603	58	0.060
embryonic genitalia morphogenesis	GO:0030538	4	0.060
lateral line system development	GO:0048925	1	0.059
regulation of multi organism process	GO:0043900	111	0.059
axonal fasciculation	GO:0007413	15	0.059
myeloid cell differentiation	GO:0030099	233	0.059
pituitary gland development	GO:0021983	38	0.058
antimicrobial peptide production	GO:0002775	2	0.058
cellular ion homeostasis	GO:0006873	165	0.058
cardiac muscle contraction	GO:0060048	32	0.058
establishment or maintenance of cell polarity	GO:0007163	86	0.058	Fly
positive regulation of voltage gated calcium channel activity	GO:1901387	2	0.058
ras protein signal transduction	GO:0007265	77	0.058
striated muscle cell development	GO:0055002	125	0.058
purine ribonucleoside triphosphate metabolic process	GO:0009205	220	0.057	Mouse
positive regulation of cell death	GO:0010942	224	0.057
operant conditioning	GO:0035106	2	0.057
oocyte axis specification	GO:0007309	2	0.057	Fly
regulation of ossification	GO:0030278	112	0.057
planar cell polarity pathway involved in ventricular septum morphogenesis	GO:0061348	2	0.057
purine nucleoside triphosphate catabolic process	GO:0009146	203	0.057	Mouse
regulation of neuron apoptotic process	GO:0043523	122	0.057	Mouse
cell communication by electrical coupling involved in cardiac conduction	GO:0086064	2	0.057
cardiac right atrium morphogenesis	GO:0003213	3	0.057
sulfur compound metabolic process	GO:0006790	100	0.056
inner ear morphogenesis	GO:0042472	101	0.056
negative regulation of embryonic development	GO:0045992	22	0.056
regulation of cellular component biogenesis	GO:0044087	181	0.056
response to inorganic substance	GO:0010035	96	0.056	Rat
regulation of cellular component size	GO:0032535	121	0.056
positive regulation of programmed cell death	GO:0043068	218	0.056
negative regulation of cellular amine metabolic process	GO:0033239	1	0.055
male gamete generation	GO:0048232	285	0.055
regulation of cell division	GO:0051302	76	0.055
positive regulation of protein transport	GO:0051222	93	0.055
embryonic heart tube development	GO:0035050	65	0.055
regulation of antimicrobial peptide biosynthetic process	GO:0002805	1	0.055
positive regulation of inositol phosphate biosynthetic process	GO:0060732	2	0.054
gastrulation	GO:0007369	116	0.054
negative regulation of neuron apoptotic process	GO:0043524	92	0.054	Mouse
axonogenesis	GO:0007409	274	0.054	Mouse
cytokine production	GO:0001816	319	0.054
bone mineralization	GO:0030282	54	0.054
negative regulation of lipid metabolic process	GO:0045833	30	0.054
morphogenesis of embryonic epithelium	GO:0016331	159	0.054	Fly
schwann cell development	GO:0014044	22	0.054
positive regulation of cell adhesion	GO:0045785	80	0.054
oogenesis	GO:0048477	56	0.054	Fly
hindbrain morphogenesis	GO:0021575	46	0.054
negative regulation of behavior	GO:0048521	14	0.053
peptide transport	GO:0015833	133	0.053
forebrain cell migration	GO:0021885	58	0.053	Mouse
cellular metal ion homeostasis	GO:0006875	151	0.053
regulation of t cell activation	GO:0050863	170	0.053	Mouse
negative regulation of multi organism process	GO:0043901	68	0.053
nucleobase containing small molecule metabolic process	GO:0055086	352	0.053	Mouse
positive regulation of cell growth	GO:0030307	33	0.052
nucleoside triphosphate metabolic process	GO:0009141	230	0.052	Mouse
regulation of cytokine production	GO:0001817	266	0.052
negative regulation of serotonin secretion	GO:0014063	2	0.052
response to acid chemical	GO:0001101	111	0.052	Mouse
ensheathment of neurons	GO:0007272	76	0.052	Mouse
planar cell polarity pathway involved in heart morphogenesis	GO:0061346	3	0.052
cytoplasmic transport	GO:0016482	234	0.052
homeostasis of number of cells	GO:0048872	210	0.051
regulation of extent of cell growth	GO:0061387	52	0.051
negative regulation of transmembrane receptor protein serine threonine kinase signaling pathway	GO:0090101	61	0.051
negative regulation of canonical wnt signaling pathway	GO:0090090	51	0.051
cardiac septum development	GO:0003279	59	0.051
positive regulation of cellular carbohydrate metabolic process	GO:0010676	29	0.051
regulation of microtubule based process	GO:0032886	52	0.051
nucleoside catabolic process	GO:0009164	206	0.051	Mouse
generation of precursor metabolites and energy	GO:0006091	103	0.050
regulation of osteoblast differentiation	GO:0045667	67	0.050
peripheral nervous system development	GO:0007422	53	0.050	Mouse Fly
female sex differentiation	GO:0046660	84	0.050
regulation of binding	GO:0051098	111	0.050
establishment of neuroblast polarity	GO:0045200	1	0.050
regulation of renin secretion into blood stream	GO:1900133	4	0.050
endocytosis	GO:0006897	168	0.049
regulation of heart growth	GO:0060420	31	0.049
regulation of ventricular cardiac muscle cell membrane depolarization	GO:0060373	2	0.049
b cell activation	GO:0042113	161	0.049
exocytosis	GO:0006887	121	0.049
rhombomere 5 development	GO:0021571	4	0.049
positive regulation of sequence specific dna binding transcription factor activity	GO:0051091	68	0.049
cellular lipid metabolic process	GO:0044255	323	0.049	Human
somatotropin secreting cell differentiation	GO:0060126	4	0.048
regulation of cell cycle process	GO:0010564	160	0.048	Fly
negative regulation of molecular function	GO:0044092	258	0.048
establishment of planar polarity	GO:0001736	28	0.048	Fly
meiotic nuclear division	GO:0007126	115	0.048
mesenchymal epithelial cell signaling	GO:0060638	9	0.048
polarity specification of proximal distal axis	GO:0010085	2	0.048
regulation of high voltage gated calcium channel activity	GO:1901841	2	0.048
male gonad development	GO:0008584	88	0.047
positive regulation of organelle organization	GO:0010638	128	0.047
organic hydroxy compound metabolic process	GO:1901615	203	0.047
morphogenesis of a branching structure	GO:0001763	203	0.047
negative regulation of neuron projection regeneration	GO:0070571	3	0.047
cardiac conduction system development	GO:0003161	12	0.047
regulation of muscle system process	GO:0090257	80	0.047
epithelium migration	GO:0090132	63	0.047	Fly
regulation of biomineral tissue development	GO:0070167	33	0.046
learning or memory	GO:0007611	148	0.046	Fly
cerebellum morphogenesis	GO:0021587	42	0.046
artery development	GO:0060840	53	0.046
phospholipase c activating serotonin receptor signaling pathway	GO:0007208	1	0.046
positive regulation of purine nucleotide catabolic process	GO:0033123	88	0.046	Mouse
regulation of organ growth	GO:0046620	61	0.046
trabecula morphogenesis	GO:0061383	40	0.046
organophosphate catabolic process	GO:0046434	232	0.045	Mouse
negative regulation of cellular amino acid metabolic process	GO:0045763	0	0.045
spemann organizer formation	GO:0060061	2	0.045
positive regulation of canonical wnt signaling pathway involved in controlling type b pancreatic cell proliferation	GO:2000081	1	0.045
meiotic cell cycle process	GO:1903046	77	0.045
developmental maturation	GO:0021700	193	0.045	Rat Fly
cell division	GO:0051301	120	0.045
alcohol metabolic process	GO:0006066	116	0.045
muscle cell proliferation	GO:0033002	52	0.045
erk1 and erk2 cascade	GO:0070371	77	0.045	Human
negative regulation of phosphorus metabolic process	GO:0010563	184	0.045
actin filament based movement	GO:0030048	23	0.045
ovulation	GO:0030728	15	0.044	Worm
androgen biosynthetic process	GO:0006702	4	0.044
positive regulation of neuron differentiation	GO:0045666	141	0.044
cell junction organization	GO:0034330	77	0.044
positive regulation of transcription from rna polymerase ii promoter involved in myocardial precursor cell differentiation	GO:0003257	3	0.044
cell cell signaling involved in cell fate commitment	GO:0045168	35	0.044
heart growth	GO:0060419	45	0.044
development of primary male sexual characteristics	GO:0046546	88	0.044

Erbb4 disease predictions

Disease predictions are made from cross-annotation of human disease genes to the identified functional analogs in mouse and predicted with the mouse functional network.

Disease	DO term ID	Probability	Func Analog Org
disease of anatomical entity	DOID:7	0.048	Human
musculoskeletal system disease	DOID:17	0.048
nervous system disease	DOID:863	0.046	Human
cardiovascular system disease	DOID:1287	0.045

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