Mus musculus

136 known processes

Pbk

PDZ binding kinase

(Aliases: TOPK,AW538537,D14Ertd732e,2810434B10Rik)

Pbk biological process predictions


Filter by process size:
Biological processGO term IDProcess sizeProbabilityFunc Analog Org
meiotic cell cycleGO:00513211220.488
dna metabolic processGO:00062593030.302
spindle assembly involved in mitosisGO:009030740.297
asymmetric stem cell divisionGO:009872230.296
protein modification by small protein conjugation or removalGO:00706472070.274
cellular response to dna damage stimulusGO:00069742070.247
asymmetric neuroblast divisionGO:005505910.245
microtubule cytoskeleton organization involved in mitosisGO:190285040.225
organelle fissionGO:00482851700.218
covalent chromatin modificationGO:00165691630.217
cell cycle comprising mitosis without cytokinesisGO:003330110.211
regulation of spindle organizationGO:009022420.186
mitotic cell cycleGO:00002781950.154
mitotic cell cycle processGO:19030471590.149
regulation of cell cycleGO:00517262810.142
meiotic cell cycle processGO:1903046770.139
microtubule cytoskeleton organizationGO:00002261570.132
nuclear divisionGO:00002801580.132
meiotic nuclear divisionGO:00071261150.113
cytokinesisGO:0000910170.112
chromatin modificationGO:00165681870.111
mitotic cytokinesisGO:000028140.109
histone serine phosphorylationGO:003540450.108
nucleotide metabolic processGO:00091173320.104
attachment of spindle microtubules to kinetochoreGO:000860840.099
microtubule based processGO:00070172360.097
regulation of microtubule cytoskeleton organizationGO:0070507370.097
regulation of exit from mitosisGO:000709610.088
organelle assemblyGO:00709251770.084
regulation of cellular catabolic processGO:00313292420.082
cytokinetic processGO:003250620.079
regulation of microtubule based processGO:0032886520.071
response to oxidative stressGO:00069791230.070
male meiosisGO:0007140370.070
regulation of microtubule polymerization or depolymerizationGO:0031110200.068
ribonucleoside triphosphate catabolic processGO:00092031990.067
positive regulation of cellular catabolic processGO:00313311480.066
germ cell developmentGO:00072811850.066
protein catabolic processGO:00301632210.062
spindle assemblyGO:0051225130.061
nucleoside phosphate metabolic processGO:00067533380.061
chromosome segregationGO:0007059480.060
mitotic nuclear divisionGO:0007067480.060
peptidyl amino acid modificationGO:00181933360.059
cellular amine metabolic processGO:0044106440.057
male gamete generationGO:00482322850.057
chromatin organizationGO:00063252060.056
sister chromatid segregationGO:0000819200.054
ubiquitin dependent protein catabolic processGO:00065111290.053
cellular nitrogen compound catabolic processGO:00442702800.052
cellular homeostasisGO:00197252400.051
regulation of cellular ketone metabolic processGO:0010565660.051
muscle tissue developmentGO:00605373080.051
microtubule based movementGO:0007018840.049
cell divisionGO:00513011200.049
female meiotic divisionGO:0007143210.049
cellular amino acid metabolic processGO:00065201030.049
ras protein signal transductionGO:0007265770.048
amine metabolic processGO:0009308450.048
cellular protein catabolic processGO:00442571550.047
positive regulation of intracellular transportGO:0032388700.047
response to inorganic substanceGO:0010035960.045
cyclin catabolic processGO:000805410.045
positive regulation of nfat protein import into nucleusGO:005153310.045
negative regulation of microtubule polymerization or depolymerizationGO:0031111150.044
regulation of organelle organizationGO:00330432890.044
nucleobase containing small molecule metabolic processGO:00550863520.043
cellular ketone metabolic processGO:0042180840.042
nucleoside triphosphate metabolic processGO:00091412300.042
response to reactive oxygen speciesGO:0000302560.042
regulation of cellular amine metabolic processGO:0033238200.042
regulation of cellular amino acid metabolic processGO:000652150.042
aromatic compound catabolic processGO:00194392860.041
oxidation reduction processGO:00551143420.041
lateral inhibitionGO:004633110.041
maintenance of locationGO:0051235890.041
regulation of mitotic cell cycleGO:00073461260.040
cation transportGO:00068123990.040
organic cyclic compound catabolic processGO:19013612950.040
positive regulation of protein modification processGO:00314012990.040
cellular response to oxidative stressGO:0034599760.039
meiosis iiGO:000713570.039
regulation of chromosome segregationGO:0051983210.039
synaptonemal complex assemblyGO:0007130130.039
spindle organizationGO:0007051280.039
protein ubiquitinationGO:00165671710.038
purine nucleoside triphosphate catabolic processGO:00091462030.038
positive regulation of cellular amino acid metabolic processGO:004576430.038
mitotic chromosome condensationGO:000707610.037
regulation of protein localizationGO:00328802310.037
negative regulation of cellular protein metabolic processGO:00322692470.037
response to radiationGO:00093141650.037
nucleoside phosphate catabolic processGO:19012922220.036
purine nucleotide metabolic processGO:00061633020.036
small gtpase mediated signal transductionGO:0007264970.035
mrna metabolic processGO:0016071840.035
regulation of double strand break repair via homologous recombinationGO:001056920.035
mitotic sister chromatid segregationGO:0000070140.034
positive regulation of protein phosphorylationGO:00019342420.034
cell type specific apoptotic processGO:00972852680.034
regulation of microtubule depolymerizationGO:0031114130.033
purine ribonucleoside triphosphate metabolic processGO:00092052200.033
synapsisGO:0007129340.033
cellular protein complex disassemblyGO:0043624360.033
positive regulation of exit from mitosisGO:003153610.033
regulation of mitotic spindle organizationGO:006023620.032
mitotic cell cycle embryonicGO:004544850.032
microtubule depolymerizationGO:0007019150.032
mitotic spindle organizationGO:0007052100.031
regulation of protein complex disassemblyGO:0043244280.031
positive regulation of cellular amine metabolic processGO:003324050.030
regulation of protein kinase activityGO:00458592320.030
chromosome organization involved in meiosisGO:0070192390.029
purine ribonucleoside metabolic processGO:00461282410.029
gonad developmentGO:00084061410.028
positive regulation of purine nucleotide metabolic processGO:19005441140.028
purine containing compound catabolic processGO:00725232130.028
developmental maturationGO:00217001930.027
regulation of protein serine threonine kinase activityGO:00719001570.027
histone modificationGO:00165701590.027
purine containing compound metabolic processGO:00725213110.027
negative regulation of molecular functionGO:00440922580.027
regulation of cell cycle processGO:00105641600.027
positive regulation of protein kinase activityGO:00458601440.027
ribonucleoside catabolic processGO:00424542060.027
endocytosisGO:00068971680.027
spermatogenesisGO:00072832840.027
homeostasis of number of cellsGO:00488722100.027
regulation of establishment of protein localizationGO:00702011810.027
purine ribonucleotide metabolic processGO:00091502900.026
ribonucleotide metabolic processGO:00092592910.026
peptidyl serine phosphorylationGO:0018105740.026
regulation of intracellular protein transportGO:0033157820.026
cell fate commitmentGO:00451652100.026
regulation of intracellular transportGO:00323861590.026
regulation of purine nucleotide metabolic processGO:19005421690.026
regulation of wnt signaling pathwayGO:00301111230.026
purine nucleoside triphosphate metabolic processGO:00091442260.026
leukocyte homeostasisGO:0001776790.026
dna packagingGO:0006323300.025
regulation of ubiquitin protein ligase activity involved in mitotic cell cycleGO:005143910.025
modification dependent protein catabolic processGO:00199411330.025
organ growthGO:00352651170.025
oogenesisGO:0048477560.024
regulation of neuron projection developmentGO:00109751690.024
regulation of kinase activityGO:00435492490.024
macromolecule catabolic processGO:00090572810.024
wnt signaling pathwayGO:00160551880.024
rho protein signal transductionGO:0007266320.024
spindle assembly involved in meiosisGO:009030640.024
muscle cell differentiationGO:00426922610.023
striated muscle tissue developmentGO:00147062930.023
regulation of attachment of spindle microtubules to kinetochoreGO:005198830.023
regulation of hydrolase activityGO:00513362460.023
cell adhesionGO:00071553290.023
cellular lipid metabolic processGO:00442553230.023
female gamete generationGO:0007292740.022
oocyte maturationGO:0001556180.022
regulation of embryonic developmentGO:0045995710.022
glycosyl compound catabolic processGO:19016582060.022
microtubule anchoringGO:003445390.022
carbohydrate derivative biosynthetic processGO:19011371830.022
nucleoside metabolic processGO:00091162460.022
neural tube formationGO:00018411080.022
ribonucleoside triphosphate metabolic processGO:00091992200.022
regulation of protein maturationGO:1903317960.022
purine nucleotide catabolic processGO:00061952110.022
heterocycle catabolic processGO:00467002800.021
positive regulation of chromosome organizationGO:2001252330.021
regulation of cell projection organizationGO:00313442060.021
carbohydrate derivative catabolic processGO:19011362310.021
dna replicationGO:0006260520.021
regulation of secretionGO:00510462740.021
positive regulation of protein transportGO:0051222930.021
regulation of cytoskeleton organizationGO:00514931220.020
cellular response to lipidGO:00713961450.020
negative regulation of phosphate metabolic processGO:00459361840.020
nuclear dna replicationGO:003326030.020
mesodermal cell migrationGO:000807840.020
axonogenesisGO:00074092740.020
transmembrane receptor protein tyrosine kinase signaling pathwayGO:00071692470.020
negative regulation of protein metabolic processGO:00512482820.020
modification dependent macromolecule catabolic processGO:00436321330.020
protein localization to organelleGO:00333651850.020
ribonucleoside metabolic processGO:00091192450.020
purine nucleoside metabolic processGO:00422782410.020
neural tube developmentGO:00219151600.020
neural precursor cell proliferationGO:00613511210.020
positive regulation of mitotic sister chromatid separationGO:190197020.019
neuroblast proliferationGO:0007405490.019
positive regulation of apoptotic processGO:00430652170.019
regulation of nucleotide catabolic processGO:00308111220.019
response to organonitrogen compoundGO:00102432460.019
chromosome movement towards spindle poleGO:005130530.019
regulation of lymphocyte activationGO:00512492400.019
posttranscriptional regulation of gene expressionGO:00106081550.019
negative regulation of protein phosphorylationGO:00019331260.019
positive regulation of intracellular protein transportGO:0090316420.019
regulation of nucleotide metabolic processGO:00061401690.018
purine ribonucleoside catabolic processGO:00461302050.018
cell maturationGO:00484691270.018
response to organic cyclic compoundGO:00140701980.018
dna ligationGO:000626630.018
regulation of nucleocytoplasmic transportGO:0046822730.018
response to iron ionGO:001003940.018
rac protein signal transductionGO:0016601130.018
regulation of chromatin bindingGO:003556170.018
myeloid cell differentiationGO:00300992330.018
organophosphate biosynthetic processGO:00904071220.018
regulation of double strand break repair via nonhomologous end joiningGO:200103220.017
spindle assembly involved in female meiosisGO:000705630.017
glycosyl compound metabolic processGO:19016572460.017
response to oxygen levelsGO:0070482620.017
response to acid chemicalGO:00011011110.017
regulation of cytoplasmic transportGO:19036491120.017
regulation of secretion by cellGO:19035302490.017
regulation of homeostatic processGO:00328441820.017
positive regulation of nucleotide catabolic processGO:0030813880.017
translesion synthesisGO:001998510.017
protein modification by small protein conjugationGO:00324461870.017
nucleoside triphosphate catabolic processGO:00091432050.017
negative regulation of protein modification processGO:00314001630.017
cleavage furrow formationGO:003608920.017
cellular chemical homeostasisGO:00550822150.017
regulation of protein targetingGO:1903533610.017
nucleotide catabolic processGO:00091662170.016
embryonic epithelial tube formationGO:00018381300.016
positive regulation of cytoplasmic transportGO:1903651400.016
nucleoside phosphate biosynthetic processGO:1901293790.016
dendrite developmentGO:00163581150.016
nucleotide biosynthetic processGO:0009165780.016
hematopoietic progenitor cell differentiationGO:00022441430.016
apoptotic signaling pathwayGO:00971903060.016
regulation of bindingGO:00510981110.016
intracellular protein transportGO:00068862040.016
development of primary sexual characteristicsGO:00451371430.016
positive regulation of nucleoside metabolic processGO:0045979910.016
regulation of protein transportGO:00512231630.016
peptidyl serine modificationGO:0018209830.015
dephosphorylationGO:00163111290.015
regulation of cellular response to stressGO:00801351590.015
regulation of nucleoside metabolic processGO:00091181300.015
dna recombinationGO:0006310920.015
regulation of ras protein signal transductionGO:00465781140.015
chromosome condensationGO:0030261100.015
neuron deathGO:00709971540.015
ribose phosphate metabolic processGO:00196932910.015
striated muscle cell developmentGO:00550021250.015
response to light stimulusGO:00094161350.015
positive regulation of protein serine threonine kinase activityGO:00719021060.015
positive regulation of kinase activityGO:00336741550.015
stem cell divisionGO:0017145300.015
epithelial cell proliferationGO:00506731740.015
cellular macromolecule catabolic processGO:00442652060.014
regulation of cellular protein catabolic processGO:1903362610.014
positive regulation of organelle organizationGO:00106381280.014
wound healingGO:00420601570.014
positive regulation of cell cycleGO:0045787920.014
positive regulation of transferase activityGO:00513471670.014
regulation of hormone levelsGO:00108172110.014
regulation of muscle tissue developmentGO:1901861970.014
regulation of cyclin dependent protein serine threonine kinase activityGO:0000079160.014
muscle cell developmentGO:00550011330.014
positive regulation of nucleotide metabolic processGO:00459811140.014
genitalia developmentGO:0048806370.014
cell cycle g2 m phase transitionGO:0044839200.014
positive regulation of purine nucleotide catabolic processGO:0033123880.014
intrinsic apoptotic signaling pathwayGO:00971931320.014
regulation of rho gtpase activityGO:0032319580.014
positive regulation of nervous system developmentGO:00519622210.014
ribonucleotide catabolic processGO:00092612080.014
negative regulation of phosphorylationGO:00423261660.014
double strand break repair via homologous recombinationGO:0000724210.014
rna processingGO:00063961050.014
circulatory system processGO:00030131970.014
synapse organizationGO:00508081250.014
anatomical structure homeostasisGO:00602491450.014
regulation of neuron differentiationGO:00456642810.014
cellular response to organonitrogen compoundGO:00714171450.014
metaphase plate congressionGO:005131020.013
carbohydrate metabolic processGO:00059752300.013
mapk cascadeGO:00001652810.013
nucleoside catabolic processGO:00091642060.013
positive regulation of nucleocytoplasmic transportGO:0046824300.013
generation of precursor metabolites and energyGO:00060911030.013
regulation of cell activationGO:00508652890.013
negative regulation of neuron deathGO:1901215980.013
ribonucleoside monophosphate metabolic processGO:0009161800.013
protein targetingGO:00066051430.013
carbohydrate homeostasisGO:00335001280.013
regulation of chromatin organizationGO:1902275570.013
regulation of rho protein signal transductionGO:0035023710.013
dna endoreduplicationGO:004202340.013
negative regulation of protein complex disassemblyGO:0043242220.013
chromosome separationGO:0051304140.013
actin cytoskeleton organizationGO:00300362200.013
positive regulation of mitotic cell cycleGO:0045931410.013
dna replication independent nucleosome assemblyGO:000633610.013
lipid biosynthetic processGO:00086101790.013
maintenance of location in cellGO:0051651240.013
peptidyl tyrosine phosphorylationGO:00181081430.013
meiotic cytokinesisGO:003320650.013
regulation of cellular component biogenesisGO:00440871810.013
regulation of proteolysisGO:00301621640.013
negative regulation of protein depolymerizationGO:1901880210.013
response to hydrogen peroxideGO:0042542320.013
mrna 3 end processingGO:0031124160.013
centrosome separationGO:005129940.013
positive regulation of gtp catabolic processGO:0033126850.013
anion transportGO:00068201770.013
ossificationGO:00015032160.013
monocarboxylic acid metabolic processGO:00327871910.012
nucleoside monophosphate catabolic processGO:0009125590.012
peptide transportGO:00158331330.012
response to growth factorGO:00708481980.012
protein autophosphorylationGO:0046777610.012
response to copper ionGO:004668830.012
sensory organ morphogenesisGO:00905962420.012
sensory perceptionGO:00076002450.012
organelle localizationGO:00516401790.012
mitotic sister chromatid separationGO:005130690.012
peptide hormone secretionGO:00300721090.012
intracellular mrna localizationGO:000829840.012
atp metabolic processGO:0046034750.012
heart growthGO:0060419450.012
digestive system developmentGO:00551232000.012
regulation of cell divisionGO:0051302760.012
female meiosis chromosome segregationGO:001632110.012
regulation of fibroblast proliferationGO:0048145340.012
purine ribonucleotide catabolic processGO:00091542080.012
positive regulation of metaphase anaphase transition of cell cycleGO:190210120.012
gtp metabolic processGO:00460391440.012
glucose homeostasisGO:00425931280.012
regulation of chromatin modificationGO:1903308570.012
energy derivation by oxidation of organic compoundsGO:0015980770.012
blastocyst developmentGO:0001824800.012
gland developmentGO:00487323300.012
protein depolymerizationGO:0051261340.012
positive regulation of chromosome segregationGO:005198440.012
purine nucleoside catabolic processGO:00061522050.012
response to ionizing radiationGO:0010212420.011
blood circulationGO:00080151950.011
response to decreased oxygen levelsGO:0036293590.011
myeloid cell homeostasisGO:00022621140.011
cofactor metabolic processGO:0051186800.011
positive regulation of gtpase activityGO:0043547850.011
cellular response to inorganic substanceGO:0071241370.011
oocyte differentiationGO:0009994350.011
regulation of protein depolymerizationGO:1901879260.011
regulation of neuron deathGO:19012141340.011
synaptonemal complex organizationGO:0070193150.011
negative regulation of protein maturationGO:1903318790.011
cellular response to organic cyclic compoundGO:0071407870.011
positive regulation of cell deathGO:00109422240.011
neuron apoptotic processGO:00514021420.011
nitrogen compound transportGO:00717052710.011
guanosine containing compound metabolic processGO:19010681440.011
nuclear importGO:0051170950.011
helper t cell chemotaxisGO:003570410.011
lymphocyte homeostasisGO:0002260640.011
protein importGO:00170381010.011
response to metal ionGO:0010038470.011
mrna processingGO:0006397630.011
regulation of histone modificationGO:0031056560.011
regulation of protein processingGO:0070613960.011
positive regulation of programmed cell deathGO:00430682180.011
purine ribonucleoside triphosphate catabolic processGO:00092071990.011
response to drugGO:0042493750.010
cellular response to hormone stimulusGO:00328701500.010
protein oligomerizationGO:0051259670.010
regulation of protein localization to nucleusGO:1900180600.010
insulin secretionGO:0030073890.010
dna repairGO:00062811070.010
microtubule organizing center organizationGO:0031023280.010
negative regulation of phosphorus metabolic processGO:00105631840.010
gene silencingGO:0016458380.010
digestive tract developmentGO:00485651900.010
stem cell differentiationGO:00488632680.010
cardiac muscle tissue developmentGO:00487381300.010
blood vessel morphogenesisGO:00485142850.010
cardiac muscle cell differentiationGO:0055007690.010
amide transportGO:00428861380.010
negative regulation of apoptotic signaling pathwayGO:20012341040.010

Pbk disease predictions

Disease predictions are made from cross-annotation of human disease genes to the identified functional analogs in mouse and predicted with the mouse functional network.

DiseaseDO term IDSizeProbabilityFunc Analog Org
disease of cellular proliferationDOID:1456600.232
cancerDOID:16200.075
organ system cancerDOID:005068600.032
thoracic cancerDOID:509300.019
breast cancerDOID:161200.019
gastrointestinal system cancerDOID:311900.014
intestinal cancerDOID:1015500.014
nervous system diseaseDOID:86300.012
disease of anatomical entityDOID:700.012