Mus musculus

5 known processes

Akr1b3

aldo-keto reductase family 1, member B3 (aldose reductase)

(Aliases: Ahr-1,ALR2,Ahr1,Aldr1,AR,Akr1b1,Aldor1)

Akr1b3 biological process predictions


Filter by process size:
Biological processGO term IDProcess sizeProbabilityFunc Analog Org
nucleotide metabolic processGO:00091173320.095
nucleobase containing small molecule metabolic processGO:00550863520.094
negative regulation of phosphorylationGO:00423261660.066
nucleoside phosphate metabolic processGO:00067533380.062
cellular amino acid metabolic processGO:00065201030.057
male gamete generationGO:00482322850.057
regulation of cellular amino acid metabolic processGO:000652150.055
purine containing compound metabolic processGO:00725213110.055
circulatory system processGO:00030131970.055
nucleoside monophosphate metabolic processGO:0009123850.054
purine nucleotide metabolic processGO:00061633020.053
negative regulation of protein phosphorylationGO:00019331260.049
regulation of system processGO:00440572000.048
negative regulation of phosphate metabolic processGO:00459361840.047
organonitrogen compound biosynthetic processGO:19015661920.047
negative regulation of protein metabolic processGO:00512482820.047
peptidyl amino acid modificationGO:00181933360.047
cellular amine metabolic processGO:0044106440.047
heart contractionGO:0060047930.046
regulation of membrane potentialGO:00423911920.046
urogenital system developmentGO:00016552610.044
renal system developmentGO:00720012250.043
transmembrane transportGO:00550854120.041
kidney developmentGO:00018222130.040
positive regulation of cellular amino acid metabolic processGO:004576430.040
spermatogenesisGO:00072832840.040
negative regulation of cellular protein metabolic processGO:00322692470.038
negative regulation of protein modification processGO:00314001630.037
peptidyl serine modificationGO:0018209830.037
inorganic cation transmembrane transportGO:00986622070.036
negative regulation of phosphorus metabolic processGO:00105631840.035
regulation of blood circulationGO:1903522930.035
nucleoside triphosphate metabolic processGO:00091412300.035
cellular ketone metabolic processGO:0042180840.035
Human Mouse
heart processGO:0003015940.035
dna metabolic processGO:00062593030.034
peptidyl serine phosphorylationGO:0018105740.034
regulation of cellular ketone metabolic processGO:0010565660.034
purine ribonucleotide metabolic processGO:00091502900.033
intrinsic apoptotic signaling pathwayGO:00971931320.033
purine containing compound biosynthetic processGO:0072522700.033
regulation of cellular amine metabolic processGO:0033238200.033
g protein coupled receptor signaling pathwayGO:00071862430.033
inflammatory responseGO:00069542440.033
regulation of inflammatory responseGO:00507271470.033
cation transportGO:00068123990.032
apoptotic signaling pathwayGO:00971903060.032
regulation of transmembrane transportGO:00347621280.032
organophosphate biosynthetic processGO:00904071220.031
cytokine productionGO:00018163190.031
hypotonic responseGO:000697130.031
atp metabolic processGO:0046034750.030
positive regulation of cellular amine metabolic processGO:003324050.030
heterocycle catabolic processGO:00467002800.030
aromatic compound catabolic processGO:00194392860.029
cation transmembrane transportGO:00986552660.029
multicellular organismal signalingGO:0035637910.029
positive regulation of programmed cell deathGO:00430682180.029
purine nucleoside metabolic processGO:00422782410.029
nitrogen compound transportGO:00717052710.028
carbohydrate derivative biosynthetic processGO:19011371830.028
amine metabolic processGO:0009308450.028
oxidation reduction processGO:00551143420.028
blood circulationGO:00080151950.028
ribonucleoside metabolic processGO:00091192450.028
regulation of ion transmembrane transporter activityGO:0032412540.027
response to organic cyclic compoundGO:00140701980.027
regulation of apoptotic signaling pathwayGO:20012331970.027
cellular response to lipidGO:00713961450.027
organic cyclic compound catabolic processGO:19013612950.027
Mouse
regulation of heart contractionGO:0008016770.026
macromolecule catabolic processGO:00090572810.026
reactive oxygen species metabolic processGO:0072593840.026
regulation of muscle system processGO:0090257800.026
regulation of purine nucleotide metabolic processGO:19005421690.026
regulation of transporter activityGO:0032409570.026
regulation of protein localizationGO:00328802310.026
transmission of nerve impulseGO:0019226760.026
regulation of defense responseGO:00313472330.026
ribonucleotide metabolic processGO:00092592910.025
negative regulation of molecular functionGO:00440922580.025
inorganic ion transmembrane transportGO:00986602340.024
cellular response to dna damage stimulusGO:00069742070.024
nucleotide catabolic processGO:00091662170.024
neuronal action potentialGO:0019228540.024
glycosyl compound metabolic processGO:19016572460.024
Human
action potentialGO:0001508780.024
adult behaviorGO:00305341350.024
cation homeostasisGO:00550802120.023
response to oxidative stressGO:00069791230.023
negative regulation of intracellular signal transductionGO:19025321670.023
regulation of hormone levelsGO:00108172110.023
Mouse
regulation of secretionGO:00510462740.023
protein localization to organelleGO:00333651850.022
purine nucleoside monophosphate metabolic processGO:0009126810.022
membrane organizationGO:00610242450.022
cellular homeostasisGO:00197252400.022
positive regulation of protein modification processGO:00314012990.021
regulation of nucleotide metabolic processGO:00061401690.021
mapk cascadeGO:00001652810.021
mrna metabolic processGO:0016071840.021
nucleoside phosphate catabolic processGO:19012922220.021
regulation of transferase activityGO:00513382630.021
cellular divalent inorganic cation homeostasisGO:00725031270.021
regulation of interleukin 8 productionGO:003267730.021
ribose phosphate metabolic processGO:00196932910.020
regulation of blood pressureGO:0008217930.020
regulation of body fluid levelsGO:00508781620.020
purine nucleoside triphosphate metabolic processGO:00091442260.020
response to organonitrogen compoundGO:00102432460.020
ribonucleotide catabolic processGO:00092612080.020
purine ribonucleoside metabolic processGO:00461282410.020
intracellular protein transportGO:00068862040.020
nucleoside metabolic processGO:00091162460.019
epithelial cell developmentGO:00020641590.019
muscle system processGO:00030121410.019
positive regulation of cell deathGO:00109422240.019
ribonucleoside monophosphate metabolic processGO:0009161800.019
organelle localizationGO:00516401790.019
muscle contractionGO:00069361010.019
regulation of hydrolase activityGO:00513362460.019
spermatid differentiationGO:00485151150.019
nucleoside phosphate biosynthetic processGO:1901293790.019
carbohydrate metabolic processGO:00059752300.018
Mouse
regulation of ion transmembrane transportGO:00347651190.018
sensory perceptionGO:00076002450.018
alpha amino acid biosynthetic processGO:1901607150.018
cell adhesionGO:00071553290.018
carbohydrate derivative catabolic processGO:19011362310.018
regulation of cytokine productionGO:00018172660.018
multicellular organism growthGO:00352641610.017
establishment of blood nerve barrierGO:000806530.017
cellular response to acid chemicalGO:0071229680.017
posttranscriptional regulation of gene expressionGO:00106081550.017
ribonucleoside triphosphate metabolic processGO:00091992200.017
ion transmembrane transportGO:00342203610.017
cellular nitrogen compound catabolic processGO:00442702800.017
cellular response to oxidative stressGO:0034599760.017
positive regulation of purine nucleotide metabolic processGO:19005441140.017
calcium ion homeostasisGO:00550741270.017
multi multicellular organism processGO:00447061090.017
Mouse
regulation of intracellular transportGO:00323861590.017
glucose homeostasisGO:00425931280.016
cell type specific apoptotic processGO:00972852680.016
nuclear transportGO:00511691390.016
cytoplasmic transportGO:00164822340.016
positive regulation of apoptotic processGO:00430652170.016
regulation of reactive oxygen species metabolic processGO:2000377400.016
regulation of mapk cascadeGO:00434082480.016
protein modification by small protein conjugationGO:00324461870.016
organophosphate catabolic processGO:00464342320.016
protein catabolic processGO:00301632210.016
regulation of ion transportGO:00432692150.016
chromatin organizationGO:00063252060.016
cellular macromolecule catabolic processGO:00442652060.016
ensheathment of neuronsGO:0007272760.016
mitotic cell cycleGO:00002781950.016
epithelial tube morphogenesisGO:00605623030.016
nucleotide biosynthetic processGO:0009165780.015
divalent inorganic cation homeostasisGO:00725071380.015
regulation of organelle organizationGO:00330432890.015
purine nucleotide catabolic processGO:00061952110.015
cellular response to biotic stimulusGO:0071216920.015
cellular amino acid biosynthetic processGO:0008652220.015
gland developmentGO:00487323300.015
lateral inhibitionGO:004633110.015
positive regulation of protein phosphorylationGO:00019342420.015
cellular response to osmotic stressGO:007147070.015
second messenger mediated signalingGO:0019932730.015
positive regulation of apoptotic signaling pathwayGO:2001235950.015
negative regulation of intrinsic apoptotic signaling pathwayGO:2001243340.015
regulation of intrinsic apoptotic signaling pathwayGO:2001242610.015
muscle adaptationGO:0043500390.015
negative regulation of potassium ion transmembrane transporter activityGO:190101730.015
interleukin 8 productionGO:003263740.015
carboxylic acid biosynthetic processGO:0046394860.015
Mouse
regulation of protein kinase activityGO:00458592320.015
synaptic transmissionGO:00072683290.014
developmental growth involved in morphogenesisGO:00605601380.014
response to osmotic stressGO:0006970210.014
rna processingGO:00063961050.014
mitochondrion distributionGO:004831140.014
tissue homeostasisGO:00018941150.014
actin cytoskeleton organizationGO:00300362200.014
striated muscle tissue developmentGO:00147062930.014
regulation of establishment of protein localizationGO:00702011810.014
engulfment of apoptotic cellGO:004365230.014
organic hydroxy compound metabolic processGO:19016152030.014
purine ribonucleoside triphosphate metabolic processGO:00092052200.014
mitochondrion organizationGO:00070051340.014
wound healingGO:00420601570.014
regulation of kinase activityGO:00435492490.014
divalent metal ion transportGO:00708381720.014
neurotransmitter transportGO:0006836760.013
cellular response to peptideGO:1901653920.013
protein processingGO:00164851630.013
small gtpase mediated signal transductionGO:0007264970.013
ribonucleoside catabolic processGO:00424542060.013
cellular ion homeostasisGO:00068731650.013
ketone catabolic processGO:004218230.013
Mouse
regulation of cellular response to stressGO:00801351590.013
transmembrane receptor protein serine threonine kinase signaling pathwayGO:00071781940.013
methylationGO:00322591340.013
positive regulation of nucleotide metabolic processGO:00459811140.013
locomotory behaviorGO:00076261950.013
skin developmentGO:00435882200.013
positive regulation of monooxygenase activityGO:003277020.013
anatomical structure homeostasisGO:00602491450.013
regulation of secretion by cellGO:19035302490.013
response to acid chemicalGO:00011011110.013
regulation of ion homeostasisGO:2000021640.013
regulation of cell projection organizationGO:00313442060.013
regulation of protein transportGO:00512231630.013
striated muscle contractionGO:0006941450.013
organic acid biosynthetic processGO:0016053860.013
Mouse
cellular response to hormone stimulusGO:00328701500.012
protein targetingGO:00066051430.012
regulation of neurotransmitter levelsGO:0001505870.012
cellular protein catabolic processGO:00442571550.012
negative regulation of cell developmentGO:00107211690.012
regulation of bindingGO:00510981110.012
purine ribonucleoside monophosphate metabolic processGO:0009167800.012
carbohydrate homeostasisGO:00335001280.012
response to lipopolysaccharideGO:00324961280.012
camera type eye developmentGO:00430102660.012
cellular response to peptide hormone stimulusGO:0071375920.012
positive regulation of ion transportGO:0043270650.012
purine ribonucleoside catabolic processGO:00461302050.012
organelle fissionGO:00482851700.012
negative regulation of apoptotic signaling pathwayGO:20012341040.012
positive regulation of reactive oxygen species metabolic processGO:2000379110.012
regulation of protein localization to nucleusGO:1900180600.012
regulation of homeostatic processGO:00328441820.011
g protein coupled receptor signaling pathway coupled to cyclic nucleotide second messengerGO:0007187550.011
cellular response to organonitrogen compoundGO:00714171450.011
microtubule cytoskeleton organizationGO:00002261570.011
cellular chemical homeostasisGO:00550822150.011
positive regulation of reactive oxygen species biosynthetic processGO:190342820.011
metal ion homeostasisGO:00550651890.011
monocarboxylic acid metabolic processGO:00327871910.011
Mouse
cognitionGO:00508901490.011
reactive oxygen species biosynthetic processGO:190340980.011
dna repairGO:00062811070.011
superoxide metabolic processGO:0006801270.011
negative regulation of camp mediated signalingGO:004395130.011
potassium ion transmembrane transportGO:0071805430.011
cellular metal ion homeostasisGO:00068751510.011
regulation of extrinsic apoptotic signaling pathwayGO:2001236770.011
retina development in camera type eyeGO:00600411190.011
cellular calcium ion homeostasisGO:00068741190.011
purine ribonucleotide catabolic processGO:00091542080.011
angiotensin activated signaling pathwayGO:003816640.011
cellular lipid metabolic processGO:00442553230.011
protein modification by small protein conjugation or removalGO:00706472070.011
cellular response to abiotic stimulusGO:0071214560.011
meiotic nuclear divisionGO:00071261150.011
generation of precursor metabolites and energyGO:00060911030.011
negative regulation of transferase activityGO:0051348850.011
purine containing compound catabolic processGO:00725232130.011
striated muscle hypertrophyGO:0014897240.011
organic hydroxy compound transportGO:0015850930.011
myotube differentiationGO:00149021050.011
nucleoside catabolic processGO:00091642060.011
positive regulation of cardiac muscle contractionGO:006045220.011
calcium ion transportGO:00068161590.011
alpha amino acid metabolic processGO:1901605590.011
learning or memoryGO:00076111480.011
regulation of protein processingGO:0070613960.011
cellular response to growth factor stimulusGO:00713631970.011
cellular component assembly involved in morphogenesisGO:00109271390.011
chloride transportGO:0006821320.011
positive regulation of cytokine productionGO:00018191740.011
cellular response to organic cyclic compoundGO:0071407870.011
intrinsic apoptotic signaling pathway in response to osmotic stressGO:000862720.011
response to inorganic substanceGO:0010035960.010
positive regulation of nervous system developmentGO:00519622210.010
protein localization to nucleusGO:00345041210.010
negative regulation of cell proliferationGO:00082852960.010
regulation of cytoplasmic transportGO:19036491120.010
calcium independent cell cell adhesion via plasma membrane cell adhesion moleculesGO:001633840.010
negative regulation of cellular component organizationGO:00511291940.010
forebrain developmentGO:00309003020.010
muscle tissue developmentGO:00605373080.010
regulation of androgen receptor signaling pathwayGO:006076530.010
endomembrane system organizationGO:00102561470.010
cellular response to lipopolysaccharideGO:0071222770.010
angiogenesisGO:00015252010.010
organonitrogen compound catabolic processGO:19015652640.010
regulation of muscle adaptationGO:0043502310.010
cyclic nucleotide metabolic processGO:0009187590.010
regulation of cellular catabolic processGO:00313292420.010
response to growth factorGO:00708481980.010
modification dependent protein catabolic processGO:00199411330.010
response to molecule of bacterial originGO:00022371430.010
chromatin modificationGO:00165681870.010

Akr1b3 disease predictions

Disease predictions are made from cross-annotation of human disease genes to the identified functional analogs in mouse and predicted with the mouse functional network.

DiseaseDO term IDSizeProbabilityFunc Analog Org
nervous system diseaseDOID:86300.020
disease of anatomical entityDOID:700.020
central nervous system diseaseDOID:33100.012
cardiovascular system diseaseDOID:128700.011
disease of metabolismDOID:001466700.011