Mus musculus

0 known processes

Hsp90b1

heat shock protein 90, beta (Grp94), member 1

(Aliases: gp96,endoplasmin,Targ2,Tra-1,GRP94,Tra1,ERp99,TA-3)

Hsp90b1 biological process predictions


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Biological processGO term IDProcess sizeProbabilityFunc Analog Org
response to topologically incorrect proteinGO:0035966250.999
endoplasmic reticulum unfolded protein responseGO:0030968190.997
cellular response to topologically incorrect proteinGO:0035967250.997
response to endoplasmic reticulum stressGO:0034976530.995
response to unfolded proteinGO:0006986210.994
er nucleus signaling pathwayGO:0006984270.987
protein transmembrane transportGO:007180680.950
protein foldingGO:0006457280.834
cellular response to interleukin 4GO:0071353210.786
positive regulation of extrinsic apoptotic signaling pathwayGO:2001238340.731
protein refoldingGO:004202610.678
protein targeting to erGO:004504720.673
cerebellar purkinje cell layer developmentGO:0021680260.651
establishment of protein localization to membraneGO:0090150540.647
protein targeting to membraneGO:0006612200.627
positive regulation of cell deathGO:00109422240.470
protein localization to organelleGO:00333651850.415
cerebellum morphogenesisGO:0021587420.375
posttranslational protein targeting to membraneGO:000662020.355
fertilizationGO:00095661270.341
protein targetingGO:00066051430.327
intracellular protein transportGO:00068862040.322
er associated ubiquitin dependent protein catabolic processGO:0030433100.297
Human
positive regulation of programmed cell deathGO:00430682180.294
cytoplasmic transportGO:00164822340.288
retina homeostasisGO:0001895230.256
transmembrane transportGO:00550854120.253
chaperone mediated protein foldingGO:0061077100.234
positive regulation of protein modification by small protein conjugation or removalGO:1903322300.219
cotranslational protein targeting to membraneGO:000661320.213
establishment of protein localization to organelleGO:00725941180.209
response to heatGO:0009408270.197
maintenance of protein localization in organelleGO:007259520.191
regulation of macrophage activationGO:0043030170.181
regulation of protein kinase activityGO:00458592320.181
anatomical structure arrangementGO:0048532200.171
negative regulation of transforming growth factor beta receptor signaling pathwayGO:0030512260.167
defecationGO:003042110.163
cerebellum developmentGO:0021549770.161
srp dependent cotranslational protein targeting to membraneGO:000661410.151
positive regulation of apoptotic processGO:00430652170.151
cellular response to nutrient levelsGO:0031669640.150
extrinsic apoptotic signaling pathwayGO:00971911260.150
cellular response to cytokine stimulusGO:00713451890.148
hindbrain morphogenesisGO:0021575460.145
response to antibioticGO:0046677110.141
regulation of translationGO:0006417710.137
response to interleukin 4GO:0070670230.136
substantia nigra developmentGO:002176220.134
genitalia morphogenesisGO:0035112110.129
lipid localizationGO:00108761260.126
Worm
muscle cell differentiationGO:00426922610.125
cerebellar cortex developmentGO:0021695480.123
positive regulation of protein phosphorylationGO:00019342420.120
hindbrain developmentGO:00309021280.118
male sex differentiationGO:00466611090.116
positive regulation of transferase activityGO:00513471670.114
positive regulation of apoptotic signaling pathwayGO:2001235950.113
striated muscle myosin thick filament assemblyGO:007168810.113
positive regulation of phagocytosisGO:0050766260.099
glycoprotein biosynthetic processGO:0009101890.096
cellular response to toxic substanceGO:009723770.095
protein localization to membraneGO:00726571080.095
cell cell recognitionGO:0009988440.094
clathrin mediated endocytosisGO:007258370.094
er overload responseGO:000698360.094
pigmentationGO:0043473710.092
regulation of apoptotic signaling pathwayGO:20012331970.091
positive regulation of protein kinase activityGO:00458601440.088
sperm egg recognitionGO:0035036370.088
cellular response to growth factor stimulusGO:00713631970.088
regulation of systemic arterial blood pressureGO:0003073610.086
positive regulation of immune response to tumor cellGO:000283960.086
posttranscriptional regulation of gene expressionGO:00106081550.084
negative regulation of cellular response to growth factor stimulusGO:0090288460.084
cellular response to biotic stimulusGO:0071216920.083
neurological system process involved in regulation of systemic arterial blood pressureGO:0001976180.080
proteasome mediated ubiquitin dependent protein catabolic processGO:0043161880.080
Human
peripheral nervous system axon regenerationGO:001401220.079
positive regulation of macrophage activationGO:0043032100.078
organelle disassemblyGO:190300820.076
positive regulation of cell migrationGO:00303351090.076
male anatomical structure morphogenesisGO:009059840.075
response to yeastGO:000187860.074
translationGO:0006412930.072
positive regulation of hydrolase activityGO:00513451480.071
ribonucleoprotein complex disassemblyGO:003298830.071
maintenance of locationGO:0051235890.070
Worm
aromatic compound catabolic processGO:00194392860.070
protein catabolic processGO:00301632210.070
Human
positive regulation of kinase activityGO:00336741550.067
cellular response to extracellular stimulusGO:0031668810.065
body morphogenesisGO:0010171450.065
positive regulation of cardiac muscle contractionGO:006045220.064
immunoglobulin productionGO:0002377730.063
regulation of transferase activityGO:00513382630.063
regulation of kinase activityGO:00435492490.062
male genitalia morphogenesisGO:004880840.062
somatic cell dna recombinationGO:0016444510.061
positive regulation of t cell activationGO:00508701010.059
positive regulation of cell activationGO:00508671580.059
single fertilizationGO:0007338820.058
apoptotic signaling pathwayGO:00971903060.058
meiotic nuclear divisionGO:00071261150.058
4 hydroxyproline metabolic processGO:001947150.057
toxin transportGO:1901998380.057
nuclear transportGO:00511691390.056
organelle localizationGO:00516401790.056
protein ubiquitinationGO:00165671710.056
lymphocyte activation involved in immune responseGO:0002285930.056
circulatory system processGO:00030131970.054
response to extracellular stimulusGO:00099911270.053
cellular macromolecule catabolic processGO:00442652060.053
Human
protein modification by small protein conjugation or removalGO:00706472070.053
cytosolic calcium ion transportGO:0060401480.051
negative regulation of transmembrane receptor protein serine threonine kinase signaling pathwayGO:0090101610.050
regulation of extrinsic apoptotic signaling pathwayGO:2001236770.049
response to starvationGO:0042594650.048
regulation of ion transportGO:00432692150.048
cell recognitionGO:0008037830.047
positive regulation of striated muscle contractionGO:004598930.046
positive regulation of cell adhesionGO:0045785800.045
positive regulation of growthGO:00459271040.045
neural nucleus developmentGO:0048857220.045
multicellular organismal reproductive behaviorGO:0033057230.045
regulation of cell motilityGO:20001452360.044
metencephalon developmentGO:0022037890.043
spermatogenesisGO:00072832840.043
positive regulation of cell motilityGO:20001471160.043
response to organic cyclic compoundGO:00140701980.043
Human
positive regulation of protein modification processGO:00314012990.042
developmental pigmentationGO:0048066400.040
leukocyte activation involved in immune responseGO:00023661260.040
protein localization to nucleusGO:00345041210.039
peptidyl proline hydroxylation to 4 hydroxy l prolineGO:001840120.039
cell activation involved in immune responseGO:00022631260.039
mrna metabolic processGO:0016071840.039
protein importGO:00170381010.039
meiotic cell cycleGO:00513211220.038
cellular protein complex assemblyGO:00436231160.038
regulation of cell migrationGO:00303342190.038
cellular response to transforming growth factor beta stimulusGO:0071560880.038
cellular component assembly involved in morphogenesisGO:00109271390.038
cellular response to external stimulusGO:0071496880.038
regulation of protein ubiquitinationGO:0031396520.037
male gamete generationGO:00482322850.036
multi multicellular organism processGO:00447061090.036
muscle tissue developmentGO:00605373080.036
lipid storageGO:0019915360.036
Worm
positive regulation of leukocyte mediated immunityGO:0002705700.036
regulation of calcium ion transport into cytosolGO:0010522310.036
negative regulation of molecular functionGO:00440922580.035
establishment of protein localization to endoplasmic reticulumGO:007259920.035
regulation of interferon gamma productionGO:0032649570.035
rna splicing via transesterification reactionsGO:0000375430.034
binding of sperm to zona pellucidaGO:0007339340.034
midbrain developmentGO:0030901350.034
regulation of intracellular transportGO:00323861590.034
macromolecule catabolic processGO:00090572810.033
Human
anatomical structure homeostasisGO:00602491450.033
positive regulation of immune effector processGO:00026991070.033
response to nutrient levelsGO:00316671090.033
myosin filament organizationGO:003103330.033
transmembrane receptor protein serine threonine kinase signaling pathwayGO:00071781940.033
positive regulation of endocytosisGO:0045807420.032
membrane organizationGO:00610242450.032
regulation of cell shapeGO:0008360390.032
regulation of transpositionGO:001052820.032
response to growth factorGO:00708481980.032
regulation of organelle organizationGO:00330432890.032
modification dependent protein catabolic processGO:00199411330.032
Human
regulation of cell projection organizationGO:00313442060.032
cellular senescenceGO:0090398110.031
regulation of cell morphogenesis involved in differentiationGO:00107691510.031
calcium ion transportGO:00068161590.031
cellular response to glucose starvationGO:004214950.031
production of molecular mediator of immune responseGO:00024401030.030
negative regulation of cellular protein metabolic processGO:00322692470.030
regulation of metal ion transportGO:00109591060.030
somatic diversification of immunoglobulins involved in immune responseGO:0002208360.030
positive regulation of cytokine productionGO:00018191740.030
regulation of lymphocyte activationGO:00512492400.030
myeloid leukocyte activationGO:0002274830.030
protein modification by small protein conjugationGO:00324461870.030
regulation of cytokine productionGO:00018172660.029
regulation of transmembrane receptor protein serine threonine kinase signaling pathwayGO:00900921120.029
dna replicationGO:0006260520.029
positive regulation of response to tumor cellGO:000283660.029
regulation of response to biotic stimulusGO:0002831380.029
cytokine productionGO:00018163190.029
protein targeting to mitochondrionGO:000662660.029
maintenance of location in cellGO:0051651240.029
positive regulation of cell morphogenesis involved in differentiationGO:0010770720.029
synaptic vesicle endocytosisGO:0048488190.028
eye pigmentationGO:004806930.028
positive regulation of protein ubiquitinationGO:0031398270.028
cellular response to starvationGO:0009267570.028
proteasomal protein catabolic processGO:0010498980.028
Human
regulation of lymphocyte mediated immunityGO:0002706840.027
positive regulation of dna replicationGO:004574090.027
divalent inorganic cation transportGO:00725111780.027
regulation of immune response to tumor cellGO:000283760.027
mitochondrial transportGO:0006839360.027
negative regulation of transpositionGO:001052920.027
response to testosteroneGO:003357430.027
nucleoside triphosphate catabolic processGO:00091432050.027
response to transforming growth factor betaGO:0071559880.027
germ cell developmentGO:00072811850.027
regulation of hydrolase activityGO:00513362460.026
Human
regulation of endopeptidase activityGO:0052548890.026
interleukin 6 productionGO:0032635580.026
intracellular steroid hormone receptor signaling pathwayGO:0030518290.026
protein hydroxylationGO:001812640.026
regulation of neuron differentiationGO:00456642810.026
cellular response to oxidative stressGO:0034599760.026
regulation of cellular response to stressGO:00801351590.026
regulation of tube sizeGO:0035150570.026
chemotaxisGO:00069352470.025
synaptic vesicle recyclingGO:0036465190.025
protein n linked glycosylation via asparagineGO:001827910.024
glycoprotein metabolic processGO:00091001160.024
transforming growth factor beta receptor signaling pathwayGO:0007179710.024
regulation of cytoplasmic transportGO:19036491120.024
t cell activationGO:00421102890.024
ribonucleotide metabolic processGO:00092592910.024
leukocyte mediated immunityGO:00024431740.024
somatic diversification of immune receptors via germline recombination within a single locusGO:0002562510.024
ubiquitin dependent protein catabolic processGO:00065111290.024
Human
isotype switchingGO:0045190360.023
positive regulation of cellular catabolic processGO:00313311480.023
actin cytoskeleton organizationGO:00300362200.023
Human
skeletal myofibril assemblyGO:001486640.023
positive regulation of cell developmentGO:00107202370.023
protein export from nucleusGO:0006611200.023
response to temperature stimulusGO:0009266550.022
cellular calcium ion homeostasisGO:00068741190.022
action potentialGO:0001508780.022
cytosolic calcium ion homeostasisGO:0051480700.022
regulation of reactive oxygen species biosynthetic processGO:190342620.022
response to estrogenGO:0043627240.022
establishment of protein localization to mitochondrionGO:0072655110.021
positive regulation of interferon alpha productionGO:003272740.021
regulation of membrane potentialGO:00423911920.021
regulation of leukocyte mediated immunityGO:00027031040.021
regulation of calcium ion transportGO:0051924690.021
epithelial cell differentiation involved in salivary gland developmentGO:006069020.020
immune effector processGO:00022523210.020
vesicle localizationGO:0051648860.020
nitrogen compound transportGO:00717052710.020
epithelial cell developmentGO:00020641590.020
macromolecule glycosylationGO:0043413550.020
regulation of type i interferon productionGO:0032479220.020
protein stabilizationGO:0050821250.020
regulation of protein modification by small protein conjugation or removalGO:1903320570.020
protein import into nucleusGO:0006606950.020
somatic recombination of immunoglobulin genes involved in immune responseGO:0002204360.019
urogenital system developmentGO:00016552610.019
b cell activation involved in immune responseGO:0002312500.019
cell junction organizationGO:0034330770.019
nucleocytoplasmic transportGO:00069131390.019
lymphocyte mediated immunityGO:00024491390.019
positive regulation of cysteine type endopeptidase activity involved in apoptotic processGO:0043280360.019
purine nucleoside metabolic processGO:00422782410.019
somatic diversification of immune receptorsGO:0002200530.019
positive regulation of nuclease activityGO:003207510.019
cytokine production involved in immune responseGO:0002367340.019
positive regulation of dendritic cell chemotaxisGO:200051010.019
spermatid differentiationGO:00485151150.019
developmental maturationGO:00217001930.019
carbohydrate metabolic processGO:00059752300.019
protein n linked glycosylationGO:0006487120.019
calcium ion transport into cytosolGO:0060402480.019
regenerationGO:0031099380.019
regulation of cellular response to growth factor stimulusGO:0090287820.018
positive regulation of reactive oxygen species biosynthetic processGO:190342820.018
regulation of ion homeostasisGO:2000021640.018
positive regulation of adaptive immune responseGO:0002821610.018
dna metabolic processGO:00062593030.018
protein localization to mitochondrionGO:0070585150.018
b cell activationGO:00421131610.018
striated muscle tissue developmentGO:00147062930.018
autophagyGO:0006914450.018
calcium ion homeostasisGO:00550741270.018
positive regulation of protein import into nucleus translocationGO:003316010.018
wound healingGO:00420601570.018
regulation of homeostatic processGO:00328441820.018
cell growthGO:00160491300.018
extracellular matrix organizationGO:00301981470.018
rna dependent dna replicationGO:000627830.018
maintenance of protein location in cellGO:0032507200.017
myosin filament assemblyGO:003103420.017
cardiocyte differentiationGO:0035051870.017
positive regulation of cytosolic calcium ion concentrationGO:0007204650.017
innate immune responseGO:00450871570.017
carbohydrate derivative biosynthetic processGO:19011371830.017
regulation of t cell activationGO:00508631700.017
fat cell differentiationGO:00454441600.017
regulation of cell adhesionGO:00301551540.017
regulation of dna replicationGO:0006275170.017
protein localization to plasma membraneGO:0072659570.017
lymphocyte proliferationGO:00466511640.016
carbohydrate homeostasisGO:00335001280.016
regulation of cysteine type endopeptidase activityGO:2000116650.016
multicellular organismal homeostasisGO:00488711640.016
cation homeostasisGO:00550802120.015
regulation of proteolysisGO:00301621640.015
cation transportGO:00068123990.015
cellular amino acid metabolic processGO:00065201030.015
cell chemotaxisGO:0060326810.015
response to steroid hormoneGO:0048545560.015
interferon gamma productionGO:0032609670.015
cellular chemical homeostasisGO:00550822150.015
macrophage activationGO:0042116270.015
positive regulation of cell substrate adhesionGO:0010811470.015
myd88 dependent toll like receptor signaling pathwayGO:000275570.015
placenta developmentGO:00018901400.015
reproductive behaviorGO:0019098320.015
regulation of circadian sleep wake cycle sleepGO:004518730.015
somatic diversification of immunoglobulinsGO:0016445430.015
negative regulation of protein metabolic processGO:00512482820.015
interleukin 6 secretionGO:007260430.015
multicellular organismal signalingGO:0035637910.015
single organism cell adhesionGO:00986021560.015
leukocyte proliferationGO:00706611720.015
regulation of cellular ketone metabolic processGO:0010565660.014
multicellular organism growthGO:00352641610.014
stress granule disassemblyGO:003561720.014
neuron migrationGO:00017641220.014
sensory organ morphogenesisGO:00905962420.014
homeostasis of number of cellsGO:00488722100.014
positive regulation of growth hormone secretionGO:006012430.014
fatty acid metabolic processGO:00066311210.014
divalent metal ion transportGO:00708381720.014
spermatid developmentGO:00072861080.014
regulation of protein stabilityGO:0031647520.014
regulation of cysteine type endopeptidase activity involved in apoptotic processGO:0043281620.014
cation transmembrane transportGO:00986552660.014
dna recombinationGO:0006310920.014
regulation of cell cycleGO:00517262810.014
positive regulation of t cell mediated immunityGO:0002711240.014
establishment of synaptic vesicle localizationGO:0097480570.014
zymogen activationGO:0031638410.013
synaptic transmissionGO:00072683290.013
establishment of organelle localizationGO:00516561220.013
nucleoside catabolic processGO:00091642060.013
purine nucleoside triphosphate catabolic processGO:00091462030.013
regulation of circadian sleep wake cycleGO:004274930.013
rna splicingGO:0008380540.013
transmission of nerve impulseGO:0019226760.013
ribose phosphate metabolic processGO:00196932910.013
insulin metabolic processGO:190114230.013
amine metabolic processGO:0009308450.013
regulation of dendritic cell chemotaxisGO:200050810.013
positive regulation of reactive oxygen species metabolic processGO:2000379110.013
forebrain developmentGO:00309003020.013
kidney developmentGO:00018222130.013
positive regulation of lymphocyte mediated immunityGO:0002708620.013
compound eye developmentGO:004874910.013
tissue homeostasisGO:00018941150.013
microtubule cytoskeleton organizationGO:00002261570.012
response to inorganic substanceGO:0010035960.012
positive regulation of cellular amino acid metabolic processGO:004576430.012
establishment of vesicle localizationGO:0051650810.012
leukocyte differentiationGO:00025213420.012
positive regulation of interferon gamma productionGO:0032729390.012
plasma membrane organizationGO:0007009900.012
regulation of cytoskeleton organizationGO:00514931220.012
negative regulation of phosphorus metabolic processGO:00105631840.012
peptidyl proline hydroxylationGO:001951130.012
response to lipopolysaccharideGO:00324961280.012
regulation of cell activationGO:00508652890.012
negative regulation of nervous system developmentGO:00519611560.012
cellular homeostasisGO:00197252400.012
molting cycleGO:0042303900.012
regulation of innate immune responseGO:0045088910.012
regulation of cell substrate adhesionGO:0010810730.012
angiogenesisGO:00015252010.012
toll like receptor signaling pathwayGO:0002224380.012
positive regulation of nervous system developmentGO:00519622210.012
glucose metabolic processGO:0006006920.012
leukocyte migrationGO:00509001240.012
regulation of reactive oxygen species metabolic processGO:2000377400.012
neuron apoptotic processGO:00514021420.012
regulation of multi organism processGO:00439001110.012
cellular response to lipopolysaccharideGO:0071222770.012
regulation of establishment of protein localizationGO:00702011810.012
cellular ketone metabolic processGO:0042180840.011
negative regulation of cell developmentGO:00107211690.011
regulation of hormone levelsGO:00108172110.011
glial cell differentiationGO:00100011310.011
genitalia developmentGO:0048806370.011
cellular lipid metabolic processGO:00442553230.011
cellular ion homeostasisGO:00068731650.011
protein maturationGO:00516041760.011
striated muscle cell developmentGO:00550021250.011
ribosomal subunit export from nucleusGO:000005410.011
pore complex assemblyGO:004693130.011
cellular nitrogen compound catabolic processGO:00442702800.011
regulation of adaptive immune response based on somatic recombination of immune receptors built from immunoglobulin superfamily domainsGO:0002822870.011
peptide transportGO:00158331330.011
response to radiationGO:00093141650.011
reactive nitrogen species metabolic processGO:200105700.011
regulation of protein serine threonine kinase activityGO:00719001570.011
pharynx developmentGO:006046510.011
negative regulation of neuron projection regenerationGO:007057130.011
divalent inorganic cation homeostasisGO:00725071380.011
lateral inhibitionGO:004633110.011
establishment of protein localization to plasma membraneGO:0090002340.011
oxidation reduction processGO:00551143420.011
vesicle uncoatingGO:007231940.011
inorganic ion transmembrane transportGO:00986602340.011
immunoglobulin mediated immune responseGO:0016064690.011
locomotory behaviorGO:00076261950.011
blood vessel morphogenesisGO:00485142850.011
regulation of endocytosisGO:0030100690.011
substrate adhesion dependent cell spreadingGO:0034446300.011
regulation of cellular catabolic processGO:00313292420.011
cellular amine metabolic processGO:0044106440.010
oocyte constructionGO:000730820.010
detection of stimulusGO:0051606840.010
adaptive immune responseGO:00022501550.010
multicellular organismal agingGO:0010259240.010
positive regulation of response to biotic stimulusGO:0002833150.010
regulation of vesicle mediated transportGO:00606271390.010
cell adhesionGO:00071553290.010
morphogenesis of embryonic epitheliumGO:00163311590.010
purine nucleoside catabolic processGO:00061522050.010
neural tube developmentGO:00219151600.010
synaptic vesicle transportGO:0048489570.010
glucose homeostasisGO:00425931280.010
leukocyte chemotaxisGO:0030595690.010

Hsp90b1 disease predictions

Disease predictions are made from cross-annotation of human disease genes to the identified functional analogs in mouse and predicted with the mouse functional network.

DiseaseDO term IDSizeProbabilityFunc Analog Org
disease of anatomical entityDOID:700.079
nervous system diseaseDOID:86300.079
central nervous system diseaseDOID:33100.050
paraplegiaDOID:60700.039
hereditary spastic paraplegiaDOID:247600.039
sensory system diseaseDOID:005015500.014
cancerDOID:16200.014
disease of cellular proliferationDOID:1456600.014
hematologic cancerDOID:253100.013
organ system cancerDOID:005068600.013
bone marrow cancerDOID:496000.013
immune system cancerDOID:006008300.013
bone diseaseDOID:008000100.012
musculoskeletal system diseaseDOID:1700.012
bone development diseaseDOID:008000600.012
connective tissue diseaseDOID:6500.012