IMP: Integrative Multi-species Prediction

Mus musculus

79 known processes

Xpo1

exportin 1, CRM1 homolog (yeast)

(Aliases: Crm1,Exp1,AA420417)

Entrez: 103573
Ensembl: ENSMUSG00000020290
UniProtKB: Q8BYY5
UniProtKB: Q6P5F9

Process Predictions
Disease Predictions

Xpo1 biological process predictions

Show only novel predictionsHighlight processes of functional analogs

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Biological process	GO term ID	Process size	Probability	Func Analog Org
dna metabolic process	GO:0006259	303	0.474
dna templated transcription termination	GO:0006353	4	0.314
rna 3 end processing	GO:0031123	20	0.277
microtubule cytoskeleton organization	GO:0000226	157	0.239
rna interference	GO:0016246	2	0.221
development of primary sexual characteristics	GO:0045137	143	0.210
organelle fission	GO:0048285	170	0.198
meiotic cell cycle	GO:0051321	122	0.178
rna phosphodiester bond hydrolysis exonucleolytic	GO:0090503	4	0.163
mitotic cell cycle process	GO:1903047	159	0.162
mitotic nuclear division	GO:0007067	48	0.160
macromolecule catabolic process	GO:0009057	281	0.152
cellular amino acid metabolic process	GO:0006520	103	0.144
nuclear division	GO:0000280	158	0.135
dna replication	GO:0006260	52	0.118
interspecies interaction between organisms	GO:0044419	83	0.096
meiotic nuclear division	GO:0007126	115	0.094
protein complex disassembly	GO:0043241	40	0.091
mitotic cell cycle	GO:0000278	195	0.087
cell division	GO:0051301	120	0.084
regulation of cell cycle	GO:0051726	281	0.082
cellular nitrogen compound catabolic process	GO:0044270	280	0.081
mitotic chromosome condensation	GO:0007076	1	0.078
cellular response to dna damage stimulus	GO:0006974	207	0.074
cellular ketone metabolic process	GO:0042180	84	0.073
mitotic sister chromatid segregation	GO:0000070	14	0.072
regulation of mitotic cell cycle	GO:0007346	126	0.071
nucleic acid phosphodiester bond hydrolysis	GO:0090305	49	0.071
chromosome segregation	GO:0007059	48	0.070
germ cell development	GO:0007281	185	0.068
regulation of protein complex disassembly	GO:0043244	28	0.068
nucleocytoplasmic transport	GO:0006913	139	0.066
gene silencing by rna	GO:0031047	19	0.064
regulation of cell projection organization	GO:0031344	206	0.063
cellular macromolecule catabolic process	GO:0044265	206	0.062
gonad development	GO:0008406	141	0.061
regulation of organelle organization	GO:0033043	289	0.059
meiotic cell cycle process	GO:1903046	77	0.058
posttranscriptional regulation of gene expression	GO:0010608	155	0.057
response to heat	GO:0009408	27	0.051
microtubule based process	GO:0007017	236	0.051
negative regulation of protein metabolic process	GO:0051248	282	0.049
macromolecular complex disassembly	GO:0032984	43	0.049
regulation of cellular catabolic process	GO:0031329	242	0.046
amine metabolic process	GO:0009308	45	0.045
organelle localization	GO:0051640	179	0.044	Human Yeast
posttranscriptional gene silencing by rna	GO:0035194	10	0.041
negative regulation of cellular protein metabolic process	GO:0032269	247	0.040
regulation of cellular ketone metabolic process	GO:0010565	66	0.038
receptor mediated endocytosis	GO:0006898	51	0.038
microtubule organizing center organization	GO:0031023	28	0.037
regulation of cell cycle process	GO:0010564	160	0.037
negative regulation of immunoglobulin mediated immune response	GO:0002890	7	0.036
mitotic sister chromatid cohesion	GO:0007064	1	0.036
regulation of neuron projection development	GO:0010975	169	0.036
establishment of organelle localization	GO:0051656	122	0.036	Human Yeast
regulation of cellular component biogenesis	GO:0044087	181	0.035
cellular component assembly involved in morphogenesis	GO:0010927	139	0.035
ras protein signal transduction	GO:0007265	77	0.035
dna repair	GO:0006281	107	0.034
chromosome organization involved in meiosis	GO:0070192	39	0.033
negative regulation of synapse assembly	GO:0051964	3	0.033
cellular amine metabolic process	GO:0044106	44	0.032
organelle assembly	GO:0070925	177	0.032	Fly
intracellular protein transport	GO:0006886	204	0.032
nucleic acid transport	GO:0050657	18	0.031	Yeast
ossification	GO:0001503	216	0.031
regulation of translation	GO:0006417	71	0.031
response to peptide	GO:1901652	136	0.031
negative regulation of cell cycle process	GO:0010948	69	0.030
regulation of neuron differentiation	GO:0045664	281	0.029
dendrite development	GO:0016358	115	0.029
rna localization	GO:0006403	23	0.029	Yeast
regulation of mrna stability	GO:0043488	23	0.029
lateral inhibition	GO:0046331	1	0.028
regulation of nuclear division	GO:0051783	56	0.028
gene silencing	GO:0016458	38	0.027
female gamete generation	GO:0007292	74	0.027
rna transport	GO:0050658	18	0.027	Yeast
heterocycle catabolic process	GO:0046700	280	0.027
aromatic compound catabolic process	GO:0019439	286	0.026
positive regulation of cellular amino acid metabolic process	GO:0045764	3	0.025
circulatory system process	GO:0003013	197	0.025
nitrogen compound transport	GO:0071705	271	0.025	Yeast
centrosome organization	GO:0051297	26	0.024
regulation of cell cycle phase transition	GO:1901987	77	0.024
centrosome cycle	GO:0007098	23	0.023
regulation of cellular amino acid metabolic process	GO:0006521	5	0.023
cell cycle checkpoint	GO:0000075	47	0.023
negative regulation of cellular component organization	GO:0051129	194	0.023
meiotic chromosome segregation	GO:0045132	19	0.023
skin development	GO:0043588	220	0.023
rna processing	GO:0006396	105	0.022
nuclear transport	GO:0051169	139	0.022
cell type specific apoptotic process	GO:0097285	268	0.022
rna stabilization	GO:0043489	9	0.022
maintenance of location	GO:0051235	89	0.021
cytoplasmic transport	GO:0016482	234	0.021
cellular lipid metabolic process	GO:0044255	323	0.021
kinetochore organization	GO:0051383	2	0.021
positive regulation of rna polymerase ii transcriptional preinitiation complex assembly	GO:0045899	2	0.020
regulation of cytoskeleton organization	GO:0051493	122	0.020
cardiac muscle contraction	GO:0060048	32	0.020
oocyte construction	GO:0007308	2	0.020
translation	GO:0006412	93	0.020
regulation of cell morphogenesis involved in differentiation	GO:0010769	151	0.020
mrna transport	GO:0051028	13	0.019	Yeast
posttranscriptional gene silencing	GO:0016441	10	0.019
dna recombination	GO:0006310	92	0.019
response to oxidative stress	GO:0006979	123	0.019
cellular response to transforming growth factor beta stimulus	GO:0071560	88	0.018
negative regulation of viral process	GO:0048525	23	0.018
male gamete generation	GO:0048232	285	0.018
cellular response to oxidative stress	GO:0034599	76	0.018
positive regulation of cell cycle	GO:0045787	92	0.018
neuron migration	GO:0001764	122	0.017
response to radiation	GO:0009314	165	0.017
mrna stabilization	GO:0048255	9	0.017
nuclear mrna surveillance	GO:0071028	1	0.016
muscle contraction	GO:0006936	101	0.016
mrna catabolic process	GO:0006402	22	0.016
negative regulation of cell cycle	GO:0045786	123	0.016
regulation of mitotic cell cycle phase transition	GO:1901990	73	0.016
regulation of circadian rhythm	GO:0042752	58	0.016
cell maturation	GO:0048469	127	0.016
actin cytoskeleton organization	GO:0030036	220	0.016
muscle system process	GO:0003012	141	0.016
spermatid development	GO:0007286	108	0.016
nucleus organization	GO:0006997	45	0.015
organic cyclic compound catabolic process	GO:1901361	295	0.015
endocytosis	GO:0006897	168	0.015
regulation of symbiosis encompassing mutualism through parasitism	GO:0043903	52	0.015
positive regulation of neuron differentiation	GO:0045666	141	0.015
regulation of rna splicing	GO:0043484	37	0.015
regulation of dna replication	GO:0006275	17	0.015
positive regulation of nervous system development	GO:0051962	221	0.015
cellular protein catabolic process	GO:0044257	155	0.015
b cell activation	GO:0042113	161	0.014
genitalia development	GO:0048806	37	0.014
positive regulation of cellular amine metabolic process	GO:0033240	5	0.014
axonogenesis	GO:0007409	274	0.014
single fertilization	GO:0007338	82	0.014
spermine metabolic process	GO:0008215	3	0.014
regulation of multi organism process	GO:0043900	111	0.014
cell recognition	GO:0008037	83	0.014
regionalization	GO:0003002	337	0.014
nucleobase containing compound transport	GO:0015931	27	0.014	Yeast
heart contraction	GO:0060047	93	0.014
interaction with symbiont	GO:0051702	14	0.014
epidermis development	GO:0008544	187	0.014
negative regulation of cell projection organization	GO:0031345	56	0.014
blood circulation	GO:0008015	195	0.014
small gtpase mediated signal transduction	GO:0007264	97	0.013
methylation	GO:0032259	134	0.013
mrna metabolic process	GO:0016071	84	0.013
nucleoside phosphate metabolic process	GO:0006753	338	0.013
protein catabolic process	GO:0030163	221	0.013
response to inorganic substance	GO:0010035	96	0.013
purine nucleoside triphosphate catabolic process	GO:0009146	203	0.013
lipid localization	GO:0010876	126	0.013
positive regulation of cell cycle process	GO:0090068	61	0.012
symbiosis encompassing mutualism through parasitism	GO:0044403	83	0.012
negative regulation of neuron projection development	GO:0010977	50	0.012
heart process	GO:0003015	94	0.012
protein modification by small protein conjugation or removal	GO:0070647	207	0.012
muscle cell differentiation	GO:0042692	261	0.012
purine ribonucleotide catabolic process	GO:0009154	208	0.012
response to extracellular stimulus	GO:0009991	127	0.012
mitotic spindle organization	GO:0007052	10	0.012
establishment of rna localization	GO:0051236	18	0.012	Yeast
sister chromatid segregation	GO:0000819	20	0.012
rna export from nucleus	GO:0006405	15	0.012	Yeast
response to light stimulus	GO:0009416	135	0.011
production of molecular mediator of immune response	GO:0002440	103	0.011
regulation of actin filament based process	GO:0032970	99	0.011
regulation of microtubule based process	GO:0032886	52	0.011
response to transforming growth factor beta	GO:0071559	88	0.011
dna alkylation	GO:0006305	43	0.011
dna catabolic process exonucleolytic	GO:0000738	3	0.011
regulation of neuron apoptotic process	GO:0043523	122	0.011
cellular protein complex assembly	GO:0043623	116	0.011
actomyosin structure organization	GO:0031032	56	0.011
negative regulation of multi organism process	GO:0043901	68	0.011
regulation of dna templated transcription termination	GO:0031554	1	0.011
3 utr mediated mrna stabilization	GO:0070935	2	0.011
lipid biosynthetic process	GO:0008610	179	0.011
regulation of cytoplasmic transport	GO:1903649	112	0.011
carbohydrate derivative biosynthetic process	GO:1901137	183	0.011
neuron death	GO:0070997	154	0.010
cellular response to metal ion	GO:0071248	31	0.010
response to peptide hormone	GO:0043434	127	0.010
protein import into nucleus	GO:0006606	95	0.010
anatomical structure homeostasis	GO:0060249	145	0.010
regulation of cellular amine metabolic process	GO:0033238	20	0.010
dna dependent dna replication	GO:0006261	24	0.010
negative regulation of cell development	GO:0010721	169	0.010
viral gene expression	GO:0019080	3	0.010
stem cell development	GO:0048864	219	0.010
regulation of cell division	GO:0051302	76	0.010
metaphase plate congression	GO:0051310	2	0.010

Xpo1 disease predictions

Disease predictions are made from cross-annotation of human disease genes to the identified functional analogs in mouse and predicted with the mouse functional network.

Disease	DO term ID	Probability
nervous system disease	DOID:863	0.037
disease of anatomical entity	DOID:7	0.037
central nervous system disease	DOID:331	0.030
neurodegenerative disease	DOID:1289	0.023

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