IMP: Integrative Multi-species Prediction

Mus musculus

0 known processes

Polr2l

polymerase (RNA) II (DNA directed) polypeptide L

(Aliases: 2510029B14Rik)

Entrez: 66491
Ensembl: ENSMUSG00000038489
UniProtKB: P62876

Process Predictions
Disease Predictions

Polr2l biological process predictions

Show only novel predictionsHighlight processes of functional analogs

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Biological process	GO term ID	Process size	Probability
regulation of cellular ketone metabolic process	GO:0010565	66	0.054
cellular ketone metabolic process	GO:0042180	84	0.050
pigmentation	GO:0043473	71	0.046
protein palmitoylation	GO:0018345	14	0.045
inorganic cation transmembrane transport	GO:0098662	207	0.045
amine metabolic process	GO:0009308	45	0.040
regulation of cellular amine metabolic process	GO:0033238	20	0.037
transmembrane transport	GO:0055085	412	0.035
protein maturation	GO:0051604	176	0.035
cellular amino acid metabolic process	GO:0006520	103	0.033
learning or memory	GO:0007611	148	0.032
oxidation reduction process	GO:0055114	342	0.029
regulation of cellular amino acid metabolic process	GO:0006521	5	0.028
positive regulation of cellular amino acid metabolic process	GO:0045764	3	0.028
protein modification by small protein conjugation or removal	GO:0070647	207	0.027
cellular amine metabolic process	GO:0044106	44	0.027
regulation of neuron differentiation	GO:0045664	281	0.026
positive regulation of nervous system development	GO:0051962	221	0.025
cation transport	GO:0006812	399	0.024
regulation of lymphocyte activation	GO:0051249	240	0.024
small gtpase mediated signal transduction	GO:0007264	97	0.023
regulation of cytokine production	GO:0001817	266	0.023
g protein coupled receptor signaling pathway	GO:0007186	243	0.022
sensory perception	GO:0007600	245	0.022
nucleobase containing small molecule metabolic process	GO:0055086	352	0.022
forebrain development	GO:0030900	302	0.021
cation transmembrane transport	GO:0098655	266	0.021
positive regulation of cell development	GO:0010720	237	0.021
compound eye development	GO:0048749	1	0.021
positive regulation of cellular amine metabolic process	GO:0033240	5	0.020
regulation of neuron projection development	GO:0010975	169	0.020
glycoprotein metabolic process	GO:0009100	116	0.020
ion transmembrane transport	GO:0034220	361	0.019
leukocyte differentiation	GO:0002521	342	0.019
regulation of organelle organization	GO:0033043	289	0.019
protein processing	GO:0016485	163	0.018
carbohydrate derivative biosynthetic process	GO:1901137	183	0.018
reactive oxygen species metabolic process	GO:0072593	84	0.018
b cell activation	GO:0042113	161	0.018
positive regulation of neuron differentiation	GO:0045666	141	0.018
response to inorganic substance	GO:0010035	96	0.017
cytokine production	GO:0001816	319	0.017
gland development	GO:0048732	330	0.017
urogenital system development	GO:0001655	261	0.017
tendon cell differentiation	GO:0035990	4	0.017
nucleoside phosphate metabolic process	GO:0006753	338	0.017
protein ubiquitination	GO:0016567	171	0.017
positive regulation of protein kinase activity	GO:0045860	144	0.016
organic cyclic compound catabolic process	GO:1901361	295	0.016
positive regulation of cytokine production	GO:0001819	174	0.016
leukocyte proliferation	GO:0070661	172	0.016
male gamete generation	GO:0048232	285	0.016
regulation of cell morphogenesis involved in differentiation	GO:0010769	151	0.016
reactive nitrogen species metabolic process	GO:2001057	0	0.016
reactive oxygen species biosynthetic process	GO:1903409	8	0.016
multicellular organismal homeostasis	GO:0048871	164	0.016
nucleotide metabolic process	GO:0009117	332	0.016
regulation of reactive oxygen species biosynthetic process	GO:1903426	2	0.015
lateral inhibition	GO:0046331	1	0.015
negative regulation of immune system process	GO:0002683	209	0.015
positive regulation of protein modification process	GO:0031401	299	0.015
response to molecule of bacterial origin	GO:0002237	143	0.015
kidney development	GO:0001822	213	0.015
lung development	GO:0030324	164	0.015
regulation of cell projection organization	GO:0031344	206	0.015
cytoplasmic transport	GO:0016482	234	0.014
lymphocyte differentiation	GO:0030098	242	0.014
purine nucleotide metabolic process	GO:0006163	302	0.014
ribose phosphate metabolic process	GO:0019693	291	0.014
ras protein signal transduction	GO:0007265	77	0.014
dendrite development	GO:0016358	115	0.014
immune effector process	GO:0002252	321	0.014
ribonucleotide metabolic process	GO:0009259	291	0.014
g protein coupled acetylcholine receptor signaling pathway	GO:0007213	4	0.014
nucleoside monophosphate metabolic process	GO:0009123	85	0.014
rho protein signal transduction	GO:0007266	32	0.014
purine containing compound metabolic process	GO:0072521	311	0.014
positive regulation of response to wounding	GO:1903036	66	0.014
positive regulation of apoptotic process	GO:0043065	217	0.014
germ cell development	GO:0007281	185	0.014
renal system development	GO:0072001	225	0.013
negative regulation of neuron differentiation	GO:0045665	101	0.013
cognition	GO:0050890	149	0.013
purine ribonucleoside metabolic process	GO:0046128	241	0.013
apoptotic signaling pathway	GO:0097190	306	0.013
regulation of membrane potential	GO:0042391	192	0.013
morphogenesis of a branching structure	GO:0001763	203	0.013
mapk cascade	GO:0000165	281	0.013
negative regulation of cell activation	GO:0050866	111	0.013
peptidyl amino acid modification	GO:0018193	336	0.013
synaptic transmission	GO:0007268	329	0.013
cell type specific apoptotic process	GO:0097285	268	0.013
negative regulation of lymphocyte activation	GO:0051250	91	0.013
positive regulation of lymphocyte activation	GO:0051251	140	0.013
regulation of transmembrane transport	GO:0034762	128	0.013
positive regulation of cell projection organization	GO:0031346	95	0.012
myotube differentiation	GO:0014902	105	0.012
positive regulation of transferase activity	GO:0051347	167	0.012
glycosylation	GO:0070085	62	0.012
rhythmic process	GO:0048511	174	0.012
lymphocyte mediated immunity	GO:0002449	139	0.012
negative regulation of cellular protein metabolic process	GO:0032269	247	0.012
negative regulation of cell development	GO:0010721	169	0.012
activation of immune response	GO:0002253	138	0.012
cellular response to dna damage stimulus	GO:0006974	207	0.012
purine ribonucleotide metabolic process	GO:0009150	290	0.012
negative regulation of protein metabolic process	GO:0051248	282	0.012
positive regulation of reactive oxygen species biosynthetic process	GO:1903428	2	0.012
regulation of anatomical structure size	GO:0090066	178	0.012
mitotic cell cycle	GO:0000278	195	0.012
inflammatory response	GO:0006954	244	0.012
transmission of nerve impulse	GO:0019226	76	0.012
organelle fission	GO:0048285	170	0.012
spermatogenesis	GO:0007283	284	0.012
skin development	GO:0043588	220	0.012
lymphocyte proliferation	GO:0046651	164	0.011
chromatin modification	GO:0016568	187	0.011
t cell differentiation in thymus	GO:0033077	77	0.011
aromatic compound catabolic process	GO:0019439	286	0.011
glycoprotein biosynthetic process	GO:0009101	89	0.011
purine nucleoside triphosphate metabolic process	GO:0009144	226	0.011
transition metal ion transport	GO:0000041	38	0.011
positive regulation of programmed cell death	GO:0043068	218	0.011
purine ribonucleoside monophosphate metabolic process	GO:0009167	80	0.011
regulation of transferase activity	GO:0051338	263	0.011
fatty acid metabolic process	GO:0006631	121	0.011
nuclear division	GO:0000280	158	0.011
developmental growth involved in morphogenesis	GO:0060560	138	0.011
regulation of kinase activity	GO:0043549	249	0.011
ribonucleoside triphosphate metabolic process	GO:0009199	220	0.011
rna processing	GO:0006396	105	0.011
alcohol metabolic process	GO:0006066	116	0.011
regulation of cell activation	GO:0050865	289	0.011
regulation of mesenchymal cell apoptotic process involved in nephron morphogenesis	GO:0072039	4	0.011
cellular lipid metabolic process	GO:0044255	323	0.011
positive regulation of cell death	GO:0010942	224	0.011
nucleoside triphosphate metabolic process	GO:0009141	230	0.011
covalent chromatin modification	GO:0016569	163	0.011
epithelial cell development	GO:0002064	159	0.010
mitochondrion organization	GO:0007005	134	0.010
skeletal muscle organ development	GO:0060538	163	0.010
negative regulation of phosphate metabolic process	GO:0045936	184	0.010
cellular response to biotic stimulus	GO:0071216	92	0.010
positive regulation of neuron projection development	GO:0010976	79	0.010
regulation of t cell activation	GO:0050863	170	0.010
microtubule based process	GO:0007017	236	0.010
positive regulation of cell activation	GO:0050867	158	0.010
learning	GO:0007612	98	0.010
chromatin organization	GO:0006325	206	0.010
dna repair	GO:0006281	107	0.010
respiratory system development	GO:0060541	190	0.010

Polr2l disease predictions

Disease predictions are made from cross-annotation of human disease genes to the identified functional analogs in mouse and predicted with the mouse functional network.

Disease	DO term ID	Probability
disease of anatomical entity	DOID:7	0.024
central nervous system disease	DOID:331	0.024
nervous system disease	DOID:863	0.024
musculoskeletal system disease	DOID:17	0.012
muscular disease	DOID:0080000	0.011
muscle tissue disease	DOID:66	0.011
cardiovascular system disease	DOID:1287	0.011
disease of cellular proliferation	DOID:14566	0.011

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