IMP: Integrative Multi-species Prediction

Mus musculus

0 known processes

Polr2h

polymerase (RNA) II (DNA directed) polypeptide H

(Aliases: MGC8248,MGC103049)

Ensembl: ENSMUSG00000021018
Entrez: 245841
UniProtKB: Q923G2

Process Predictions
Disease Predictions

Polr2h biological process predictions

Show only novel predictionsHighlight processes of functional analogs

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Biological process	GO term ID	Process size	Probability
positive regulation of mitochondrion organization	GO:0010822	17	0.147
cellular nitrogen compound catabolic process	GO:0044270	280	0.124
rna processing	GO:0006396	105	0.120
mrna metabolic process	GO:0016071	84	0.097
organic cyclic compound catabolic process	GO:1901361	295	0.094
nucleoside triphosphate metabolic process	GO:0009141	230	0.082
macromolecule methylation	GO:0043414	120	0.071
establishment of rna localization	GO:0051236	18	0.069
negative regulation of molecular function	GO:0044092	258	0.066
aromatic compound catabolic process	GO:0019439	286	0.065
oocyte construction	GO:0007308	2	0.064
heterocycle catabolic process	GO:0046700	280	0.064
intracellular mrna localization	GO:0008298	4	0.055
pole plasm assembly	GO:0007315	2	0.049
oocyte anterior posterior axis specification	GO:0007314	2	0.047
nucleic acid transport	GO:0050657	18	0.042
nitrogen compound transport	GO:0071705	271	0.042
carbohydrate derivative biosynthetic process	GO:1901137	183	0.038
mrna catabolic process	GO:0006402	22	0.037
cation transport	GO:0006812	399	0.035
amine metabolic process	GO:0009308	45	0.035
female gamete generation	GO:0007292	74	0.034
ion transmembrane transport	GO:0034220	361	0.033
transmembrane transport	GO:0055085	412	0.032
organonitrogen compound biosynthetic process	GO:1901566	192	0.032
organophosphate biosynthetic process	GO:0090407	122	0.031
nucleobase containing compound transport	GO:0015931	27	0.030
regulation of cellular amino acid metabolic process	GO:0006521	5	0.029
rna splicing via transesterification reactions with bulged adenosine as nucleophile	GO:0000377	43	0.029
methylation	GO:0032259	134	0.029
nucleotide metabolic process	GO:0009117	332	0.028
rna splicing via transesterification reactions	GO:0000375	43	0.028
negative regulation of cellular protein metabolic process	GO:0032269	247	0.028
cellular homeostasis	GO:0019725	240	0.027
regulation of cellular ketone metabolic process	GO:0010565	66	0.027
cytoplasmic transport	GO:0016482	234	0.027
small gtpase mediated signal transduction	GO:0007264	97	0.027
germ cell development	GO:0007281	185	0.026
nuclear transcribed mrna catabolic process	GO:0000956	16	0.026
regulation of ras protein signal transduction	GO:0046578	114	0.026
regulation of cellular amine metabolic process	GO:0033238	20	0.025
cellular amine metabolic process	GO:0044106	44	0.025
cell type specific apoptotic process	GO:0097285	268	0.025
regulation of ion transport	GO:0043269	215	0.024
muscle tissue development	GO:0060537	308	0.024
ras protein signal transduction	GO:0007265	77	0.023
cellular macromolecule catabolic process	GO:0044265	206	0.023
nucleoside phosphate metabolic process	GO:0006753	338	0.023
ribonucleoside triphosphate metabolic process	GO:0009199	220	0.022
positive regulation of organelle organization	GO:0010638	128	0.022
negative regulation of phosphate metabolic process	GO:0045936	184	0.022
segmentation	GO:0035282	93	0.022
atp metabolic process	GO:0046034	75	0.021
nucleobase containing small molecule metabolic process	GO:0055086	352	0.021
ncrna processing	GO:0034470	26	0.020
negative regulation of cell proliferation	GO:0008285	296	0.020
macromolecule catabolic process	GO:0009057	281	0.019
cellular lipid metabolic process	GO:0044255	323	0.019
nucleolus organization	GO:0007000	5	0.019
microtubule based process	GO:0007017	236	0.019
nucleotide catabolic process	GO:0009166	217	0.018
striated muscle cell development	GO:0055002	125	0.018
regulation of homeostatic process	GO:0032844	182	0.018
rna catabolic process	GO:0006401	29	0.017
posttranscriptional regulation of gene expression	GO:0010608	155	0.016
spermatogenesis	GO:0007283	284	0.016
oocyte axis specification	GO:0007309	2	0.016
cellular ketone metabolic process	GO:0042180	84	0.016
symbiosis encompassing mutualism through parasitism	GO:0044403	83	0.016
negative regulation of protein modification process	GO:0031400	163	0.016
negative regulation of protein metabolic process	GO:0051248	282	0.016
development of primary sexual characteristics	GO:0045137	143	0.016
muscle cell development	GO:0055001	133	0.016
sensory perception	GO:0007600	245	0.016
mapk cascade	GO:0000165	281	0.016
positive regulation of cellular amine metabolic process	GO:0033240	5	0.016
divalent inorganic cation homeostasis	GO:0072507	138	0.015
striated muscle tissue development	GO:0014706	293	0.015
response to acid chemical	GO:0001101	111	0.015
regulation of cellular component biogenesis	GO:0044087	181	0.015
regulation of mitochondrion organization	GO:0010821	27	0.015
nucleoside metabolic process	GO:0009116	246	0.015
divalent metal ion transport	GO:0070838	172	0.014
immune response activating cell surface receptor signaling pathway	GO:0002429	72	0.014
cell maturation	GO:0048469	127	0.014
positive regulation of protein modification process	GO:0031401	299	0.014
regulation of erk1 and erk2 cascade	GO:0070372	71	0.014
maternal determination of anterior posterior axis embryo	GO:0008358	2	0.014
purine nucleotide biosynthetic process	GO:0006164	65	0.014
muscle cell differentiation	GO:0042692	261	0.014
ribonucleoside metabolic process	GO:0009119	245	0.014
regulation of mapk cascade	GO:0043408	248	0.014
purine containing compound metabolic process	GO:0072521	311	0.014
nuclear transport	GO:0051169	139	0.013
maturation of ssu rrna	GO:0030490	1	0.013
regulation of cell projection organization	GO:0031344	206	0.013
neuron death	GO:0070997	154	0.013
regulation of nucleoside metabolic process	GO:0009118	130	0.013
t cell activation	GO:0042110	289	0.013
organelle assembly	GO:0070925	177	0.013
stem cell differentiation	GO:0048863	268	0.013
mitochondrial membrane organization	GO:0007006	26	0.012
reactive oxygen species metabolic process	GO:0072593	84	0.012
myeloid cell differentiation	GO:0030099	233	0.012
positive regulation of protein phosphorylation	GO:0001934	242	0.012
purine nucleoside metabolic process	GO:0042278	241	0.012
epithelial cell proliferation	GO:0050673	174	0.012
cellular ion homeostasis	GO:0006873	165	0.012
nucleoside biosynthetic process	GO:0009163	21	0.012
calcium ion transport	GO:0006816	159	0.012
actin cytoskeleton organization	GO:0030036	220	0.012
rna splicing	GO:0008380	54	0.012
regulation of neuron differentiation	GO:0045664	281	0.012
cellular carbohydrate metabolic process	GO:0044262	119	0.012
nucleoside phosphate biosynthetic process	GO:1901293	79	0.012
developmental maturation	GO:0021700	193	0.011
chromatin modification	GO:0016568	187	0.011
organelle fission	GO:0048285	170	0.011
striated muscle myosin thick filament assembly	GO:0071688	1	0.011
membrane organization	GO:0061024	245	0.011
cation homeostasis	GO:0055080	212	0.011
embryonic organ morphogenesis	GO:0048562	276	0.011
cation transmembrane transport	GO:0098655	266	0.011
respiratory tube development	GO:0030323	167	0.011
positive regulation of the force of heart contraction by chemical signal	GO:0003099	3	0.011
generation of precursor metabolites and energy	GO:0006091	103	0.011
negative regulation of cell development	GO:0010721	169	0.011
inorganic ion transmembrane transport	GO:0098660	234	0.011
ribose phosphate biosynthetic process	GO:0046390	59	0.011
oocyte development	GO:0048599	33	0.011
ribonucleotide metabolic process	GO:0009259	291	0.011
cell division	GO:0051301	120	0.011
divalent inorganic cation transport	GO:0072511	178	0.011
covalent chromatin modification	GO:0016569	163	0.011
nucleocytoplasmic transport	GO:0006913	139	0.010
ossification	GO:0001503	216	0.010
mitotic nuclear division	GO:0007067	48	0.010
regulation of epithelial cell proliferation	GO:0050678	141	0.010
leukocyte differentiation	GO:0002521	342	0.010

Polr2h disease predictions

Disease predictions are made from cross-annotation of human disease genes to the identified functional analogs in mouse and predicted with the mouse functional network.

Disease	DO term ID	Probability
nervous system disease	DOID:863	0.040
disease of anatomical entity	DOID:7	0.040
central nervous system disease	DOID:331	0.020
neurodegenerative disease	DOID:1289	0.010

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