IMP: Integrative Multi-species Prediction

Mus musculus

72 known processes

Mre11a

meiotic recombination 11 homolog A (S. cerevisiae)

(Aliases: Mre11b,Mre11)

Entrez: 17535
Ensembl: ENSMUSG00000031928
UniProtKB: Q3URU4
UniProtKB: Q61216

Process Predictions
Disease Predictions

Mre11a biological process predictions

Show only novel predictionsHighlight processes of functional analogs

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Biological process	GO term ID	Process size	Probability	Func Analog Org
dna metabolic process	GO:0006259	303	0.769
dna repair	GO:0006281	107	0.451
double strand break repair	GO:0006302	48	0.392
telomere capping	GO:0016233	4	0.359	Fly
meiotic cell cycle process	GO:1903046	77	0.285
nuclear division	GO:0000280	158	0.228
mitotic cell cycle process	GO:1903047	159	0.175
meiotic cell cycle	GO:0051321	122	0.172
regulation of protein autophosphorylation	GO:0031952	8	0.163	Human
telomere maintenance	GO:0000723	19	0.159	Fly
organelle fission	GO:0048285	170	0.155
dna replication	GO:0006260	52	0.149	Human
mitotic recombination	GO:0006312	3	0.148
microtubule based process	GO:0007017	236	0.138
chromosome organization involved in meiosis	GO:0070192	39	0.136
dna conformation change	GO:0071103	37	0.126	Human
synapsis	GO:0007129	34	0.125
anatomical structure homeostasis	GO:0060249	145	0.115	Fly
cellular hyperosmotic salinity response	GO:0071475	0	0.115
dna recombination	GO:0006310	92	0.110	Yeast
heterocycle catabolic process	GO:0046700	280	0.095	Human Yeast
negative regulation of cell cycle	GO:0045786	123	0.093
aromatic compound catabolic process	GO:0019439	286	0.090	Human Yeast
microtubule organizing center organization	GO:0031023	28	0.084
somatic recombination of immunoglobulin gene segments	GO:0016447	42	0.078
positive regulation of protein phosphorylation	GO:0001934	242	0.073	Human
microtubule cytoskeleton organization	GO:0000226	157	0.071
chromosome segregation	GO:0007059	48	0.067	Human Worm
positive regulation of protein modification process	GO:0031401	299	0.066	Human
rna dependent dna replication	GO:0006278	3	0.065
organic cyclic compound catabolic process	GO:1901361	295	0.063	Human Yeast
dna duplex unwinding	GO:0032508	7	0.060	Human
somatic diversification of immune receptors via germline recombination within a single locus	GO:0002562	51	0.058
cellular amino acid metabolic process	GO:0006520	103	0.056
cellular macromolecule catabolic process	GO:0044265	206	0.055	Yeast
regulation of transferase activity	GO:0051338	263	0.055	Human
organelle assembly	GO:0070925	177	0.055
regulation of mitotic cell cycle	GO:0007346	126	0.053
cellular nitrogen compound catabolic process	GO:0044270	280	0.050	Human Yeast
cellular response to dna damage stimulus	GO:0006974	207	0.047
nuclear transport	GO:0051169	139	0.046
mitotic cell cycle	GO:0000278	195	0.045
negative regulation of cell cycle process	GO:0010948	69	0.044
cytoplasmic transport	GO:0016482	234	0.042
nucleic acid phosphodiester bond hydrolysis	GO:0090305	49	0.040	Yeast
somatic cell dna recombination	GO:0016444	51	0.039
meiotic nuclear division	GO:0007126	115	0.039
nuclear dna replication	GO:0033260	3	0.039
regulation of cell cycle	GO:0051726	281	0.038
gene silencing	GO:0016458	38	0.038
establishment of organelle localization	GO:0051656	122	0.038
chromatin organization	GO:0006325	206	0.038
negative regulation of mitotic cell cycle	GO:0045930	58	0.037
mitotic nuclear division	GO:0007067	48	0.036
regulation of cell cycle process	GO:0010564	160	0.035
meiosis i	GO:0007127	60	0.035
apoptotic signaling pathway	GO:0097190	306	0.034
organelle localization	GO:0051640	179	0.033
peptidyl amino acid modification	GO:0018193	336	0.033
blastocyst development	GO:0001824	80	0.032
regulation of organelle organization	GO:0033043	289	0.032
regulation of cellular ketone metabolic process	GO:0010565	66	0.032
response to x ray	GO:0010165	11	0.032
reciprocal dna recombination	GO:0035825	16	0.032	Yeast
cellular ketone metabolic process	GO:0042180	84	0.032
nucleocytoplasmic transport	GO:0006913	139	0.031
positive regulation of protein autophosphorylation	GO:0031954	4	0.030	Human
intracellular protein transport	GO:0006886	204	0.030
ribose phosphate metabolic process	GO:0019693	291	0.029	Human
telomere maintenance via telomerase	GO:0007004	1	0.029
organonitrogen compound catabolic process	GO:1901565	264	0.028	Human
negative regulation of cellular component organization	GO:0051129	194	0.028
cellular amine metabolic process	GO:0044106	44	0.027
cell cycle checkpoint	GO:0000075	47	0.026
dna geometric change	GO:0032392	7	0.026	Human
positive regulation of hydrolase activity	GO:0051345	148	0.026
endocytosis	GO:0006897	168	0.026
nucleobase containing small molecule metabolic process	GO:0055086	352	0.025	Human Yeast
glycosyl compound metabolic process	GO:1901657	246	0.025	Human
somatic diversification of immunoglobulins	GO:0016445	43	0.025
cell activation involved in immune response	GO:0002263	126	0.025
purine ribonucleoside triphosphate catabolic process	GO:0009207	199	0.024	Human
regulation of protein localization	GO:0032880	231	0.024
synaptonemal complex assembly	GO:0007130	13	0.024
regulation of mitotic cell cycle phase transition	GO:1901990	73	0.024
posttranscriptional regulation of gene expression	GO:0010608	155	0.024
regulation of cellular amino acid metabolic process	GO:0006521	5	0.024
macromolecule catabolic process	GO:0009057	281	0.023	Yeast
regulation of cytoskeleton organization	GO:0051493	122	0.023
spindle assembly involved in mitosis	GO:0090307	4	0.023
protein autophosphorylation	GO:0046777	61	0.023	Human
chemotaxis	GO:0006935	247	0.023
positive regulation of cellular amino acid metabolic process	GO:0045764	3	0.022
positive regulation of kinase activity	GO:0033674	155	0.022	Human
ribonucleotide metabolic process	GO:0009259	291	0.022	Human
amine metabolic process	GO:0009308	45	0.022
positive regulation of transferase activity	GO:0051347	167	0.022	Human
regulation of dna recombination	GO:0000018	34	0.021
immunoglobulin production	GO:0002377	73	0.021
carbohydrate derivative biosynthetic process	GO:1901137	183	0.021
regulation of cell cycle phase transition	GO:1901987	77	0.021
positive regulation of cellular amine metabolic process	GO:0033240	5	0.021
intrinsic apoptotic signaling pathway	GO:0097193	132	0.021
immune effector process	GO:0002252	321	0.021
organophosphate catabolic process	GO:0046434	232	0.020	Human
methylation	GO:0032259	134	0.020
non recombinational repair	GO:0000726	10	0.020	Yeast
establishment of protein localization to organelle	GO:0072594	118	0.020
dna catabolic process endonucleolytic	GO:0000737	15	0.020	Yeast
protein import	GO:0017038	101	0.020
mrna processing	GO:0006397	63	0.020
immunoglobulin production involved in immunoglobulin mediated immune response	GO:0002381	43	0.020
nitrogen compound transport	GO:0071705	271	0.020
purine ribonucleotide metabolic process	GO:0009150	290	0.019	Human
ribonucleoside catabolic process	GO:0042454	206	0.019	Human
leukocyte mediated immunity	GO:0002443	174	0.019
carbohydrate derivative catabolic process	GO:1901136	231	0.019	Human
regulation of kinase activity	GO:0043549	249	0.019	Human
receptor mediated endocytosis	GO:0006898	51	0.019
chromatin modification	GO:0016568	187	0.019
ras protein signal transduction	GO:0007265	77	0.018
protein targeting	GO:0006605	143	0.018
dendrite development	GO:0016358	115	0.018
centrosome cycle	GO:0007098	23	0.018
response to radiation	GO:0009314	165	0.018
protein localization to nucleus	GO:0034504	121	0.017
nucleoside phosphate metabolic process	GO:0006753	338	0.017	Human Yeast
protein alkylation	GO:0008213	81	0.017
mitotic cell cycle checkpoint	GO:0007093	31	0.017
nuclear import	GO:0051170	95	0.017
purine nucleoside triphosphate metabolic process	GO:0009144	226	0.017	Human
negative regulation of cell proliferation	GO:0008285	296	0.017
gonad development	GO:0008406	141	0.017
regulation of hydrolase activity	GO:0051336	246	0.017
double strand break repair via nonhomologous end joining	GO:0006303	10	0.017	Yeast
lymphocyte mediated immunity	GO:0002449	139	0.017
purine nucleotide metabolic process	GO:0006163	302	0.017	Human
cellular response to organonitrogen compound	GO:0071417	145	0.017
negative regulation of dna replication	GO:0008156	4	0.016	Human
purine nucleoside catabolic process	GO:0006152	205	0.016	Human
negative regulation of cellular protein metabolic process	GO:0032269	247	0.016
protein methylation	GO:0006479	81	0.016
spindle organization	GO:0007051	28	0.016
maintenance of location	GO:0051235	89	0.016	Worm
somatic diversification of immunoglobulins involved in immune response	GO:0002208	36	0.016
nucleotide metabolic process	GO:0009117	332	0.016	Human Yeast
b cell mediated immunity	GO:0019724	71	0.016
positive regulation of nervous system development	GO:0051962	221	0.016
negative regulation of cell cycle phase transition	GO:1901988	48	0.015
response to inorganic substance	GO:0010035	96	0.015
ribonucleoside triphosphate metabolic process	GO:0009199	220	0.015	Human
male meiosis	GO:0007140	37	0.015
fertilization	GO:0009566	127	0.015
metaphase plate congression	GO:0051310	2	0.015
neuromuscular process controlling balance	GO:0050885	59	0.015
small gtpase mediated signal transduction	GO:0007264	97	0.015
dephosphorylation	GO:0016311	129	0.015
purine containing compound metabolic process	GO:0072521	311	0.015	Human
regulation of protein transport	GO:0051223	163	0.015
somatic diversification of immune receptors	GO:0002200	53	0.015
glycosyl compound catabolic process	GO:1901658	206	0.014	Human
symbiosis encompassing mutualism through parasitism	GO:0044403	83	0.014
peptidyl serine modification	GO:0018209	83	0.014
dna packaging	GO:0006323	30	0.014
protein import into nucleus	GO:0006606	95	0.014
skeletal system development	GO:0001501	356	0.014
immunoglobulin mediated immune response	GO:0016064	69	0.014
cellular protein complex assembly	GO:0043623	116	0.014
ribonucleoprotein complex localization	GO:0071166	1	0.014
lymphocyte activation involved in immune response	GO:0002285	93	0.014
regulation of cell activation	GO:0050865	289	0.014
chromosome separation	GO:0051304	14	0.014
response to organic cyclic compound	GO:0014070	198	0.014
g2 dna damage checkpoint	GO:0031572	8	0.014
positive regulation of cell cycle	GO:0045787	92	0.013	Worm
negative regulation of cellular amine metabolic process	GO:0033239	1	0.013
regulation of cytoplasmic transport	GO:1903649	112	0.013
neuron migration	GO:0001764	122	0.013
regulation of cell division	GO:0051302	76	0.013
locomotory behavior	GO:0007626	195	0.013
regulation of protein targeting	GO:1903533	61	0.013
cellular response to oxidative stress	GO:0034599	76	0.013
adaptive immune response based on somatic recombination of immune receptors built from immunoglobulin superfamily domains	GO:0002460	145	0.013
regulation of establishment of protein localization	GO:0070201	181	0.013
nucleoside catabolic process	GO:0009164	206	0.013	Human
skin development	GO:0043588	220	0.013
reciprocal meiotic recombination	GO:0007131	16	0.013	Yeast
organophosphate biosynthetic process	GO:0090407	122	0.013
b cell activation involved in immune response	GO:0002312	50	0.013
positive regulation of apoptotic process	GO:0043065	217	0.013
oxidation reduction process	GO:0055114	342	0.013
mrna metabolic process	GO:0016071	84	0.013
purine nucleoside metabolic process	GO:0042278	241	0.013	Human
embryonic organ morphogenesis	GO:0048562	276	0.013
ribonucleoside triphosphate catabolic process	GO:0009203	199	0.012	Human
muscle tissue development	GO:0060537	308	0.012
protein maturation	GO:0051604	176	0.012
endomembrane system organization	GO:0010256	147	0.012
purine nucleotide catabolic process	GO:0006195	211	0.012	Human
nucleoside metabolic process	GO:0009116	246	0.012	Human
production of molecular mediator of immune response	GO:0002440	103	0.012
cell fate commitment	GO:0045165	210	0.012
ribonucleotide catabolic process	GO:0009261	208	0.012	Human
glycerophospholipid metabolic process	GO:0006650	71	0.012
regulation of centriole replication	GO:0046599	1	0.012
leukocyte proliferation	GO:0070661	172	0.012
sister chromatid segregation	GO:0000819	20	0.012
positive regulation of protein transport	GO:0051222	93	0.012
carbohydrate metabolic process	GO:0005975	230	0.012
response to organonitrogen compound	GO:0010243	246	0.012
nucleoside triphosphate metabolic process	GO:0009141	230	0.012	Human
negative regulation of organelle organization	GO:0010639	90	0.012
nuclear export	GO:0051168	34	0.012
purine ribonucleoside metabolic process	GO:0046128	241	0.012	Human
purine ribonucleotide catabolic process	GO:0009154	208	0.012	Human
mitotic g2 dna damage checkpoint	GO:0007095	8	0.012
negative regulation of phosphate metabolic process	GO:0045936	184	0.011
viral process	GO:0016032	41	0.011
single organism nuclear import	GO:1902593	95	0.011
regulation of protein stability	GO:0031647	52	0.011
muscle cell differentiation	GO:0042692	261	0.011
dna modification	GO:0006304	50	0.011
protein dna complex subunit organization	GO:0071824	28	0.011
protein catabolic process	GO:0030163	221	0.011
hematopoietic progenitor cell differentiation	GO:0002244	143	0.011
blastocyst growth	GO:0001832	23	0.011
regulation of cellular catabolic process	GO:0031329	242	0.011
regulation of intracellular protein transport	GO:0033157	82	0.011
lipid biosynthetic process	GO:0008610	179	0.011
positive regulation of organelle organization	GO:0010638	128	0.011
regulation of intracellular transport	GO:0032386	159	0.011
organonitrogen compound biosynthetic process	GO:1901566	192	0.011
cellular chemical homeostasis	GO:0055082	215	0.011
protein localization to organelle	GO:0033365	185	0.011
regulation of nucleocytoplasmic transport	GO:0046822	73	0.011
regulation of symbiosis encompassing mutualism through parasitism	GO:0043903	52	0.011
cellular response to inorganic substance	GO:0071241	37	0.011
negative regulation of phosphorylation	GO:0042326	166	0.011
cation transport	GO:0006812	399	0.010
response to light stimulus	GO:0009416	135	0.010
purine ribonucleoside triphosphate metabolic process	GO:0009205	220	0.010	Human
ribonucleoside metabolic process	GO:0009119	245	0.010	Human
covalent chromatin modification	GO:0016569	163	0.010
positive regulation of cell development	GO:0010720	237	0.010
spermatogenesis	GO:0007283	284	0.010
rhythmic process	GO:0048511	174	0.010
forebrain development	GO:0030900	302	0.010
regulation of cellular amine metabolic process	GO:0033238	20	0.010
response to drug	GO:0042493	75	0.010
striated muscle tissue development	GO:0014706	293	0.010
cellular response to hormone stimulus	GO:0032870	150	0.010
regulation of lipid metabolic process	GO:0019216	118	0.010

Mre11a disease predictions

Disease predictions are made from cross-annotation of human disease genes to the identified functional analogs in mouse and predicted with the mouse functional network.

Disease	DO term ID	Probability
cancer	DOID:162	0.044
disease of cellular proliferation	DOID:14566	0.044
hematopoietic system disease	DOID:74	0.030
bone marrow disease	DOID:4961	0.030
disease of anatomical entity	DOID:7	0.030
immune system disease	DOID:2914	0.030
organ system cancer	DOID:0050686	0.028
immune system cancer	DOID:0060083	0.028
hematologic cancer	DOID:2531	0.028
anemia	DOID:2355	0.019
aplastic anemia	DOID:12449	0.019
leukemia	DOID:1240	0.016
nervous system disease	DOID:863	0.012

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