IMP: Integrative Multi-species Prediction

Mus musculus

0 known processes

Psmc2

proteasome (prosome, macropain) 26S subunit, ATPase 2

Ensembl: ENSMUSG00000028932
Entrez: 19181
UniProtKB: Q8BVQ9

Process Predictions
Disease Predictions

Psmc2 biological process predictions

Show only novel predictionsHighlight processes of functional analogs

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Biological process	GO term ID	Process size	Probability	Func Analog Org
proteasomal protein catabolic process	GO:0010498	98	0.954
proteasome mediated ubiquitin dependent protein catabolic process	GO:0043161	88	0.926
ubiquitin dependent protein catabolic process	GO:0006511	129	0.877	Human Yeast
modification dependent macromolecule catabolic process	GO:0043632	133	0.872	Human Yeast
protein catabolic process	GO:0030163	221	0.864	Human Yeast
regulation of rna polymerase ii transcriptional preinitiation complex assembly	GO:0045898	2	0.860	Yeast
modification dependent protein catabolic process	GO:0019941	133	0.840	Human Yeast
proteolysis involved in cellular protein catabolic process	GO:0051603	147	0.838	Human Yeast
spindle assembly involved in mitosis	GO:0090307	4	0.838
proteasome assembly	GO:0043248	1	0.825	Yeast
microtubule cytoskeleton organization involved in mitosis	GO:1902850	4	0.772
cellular macromolecule catabolic process	GO:0044265	206	0.726	Human Yeast
macromolecule catabolic process	GO:0009057	281	0.696	Human Yeast
cellular protein catabolic process	GO:0044257	155	0.682	Human Yeast
mitotic cell cycle	GO:0000278	195	0.613
mitotic cell cycle process	GO:1903047	159	0.591
cellular response to dna damage stimulus	GO:0006974	207	0.580	Fly
dna templated transcriptional preinitiation complex assembly	GO:0070897	4	0.574	Yeast
dna metabolic process	GO:0006259	303	0.523
sperm egg recognition	GO:0035036	37	0.404
proteasomal ubiquitin independent protein catabolic process	GO:0010499	1	0.380
fertilization	GO:0009566	127	0.373
gonad development	GO:0008406	141	0.270
mitotic nuclear division	GO:0007067	48	0.233
protein modification by small protein removal	GO:0070646	21	0.194
positive regulation of hydrolase activity	GO:0051345	148	0.193
organelle fission	GO:0048285	170	0.191
nuclear division	GO:0000280	158	0.175
protein modification by small protein conjugation or removal	GO:0070647	207	0.164
cellular protein complex assembly	GO:0043623	116	0.148	Yeast
protein modification by small protein conjugation	GO:0032446	187	0.148
negative regulation of protein metabolic process	GO:0051248	282	0.147
regulation of proteolysis involved in cellular protein catabolic process	GO:1903050	56	0.141
camera type eye development	GO:0043010	266	0.140
ribonucleoside monophosphate catabolic process	GO:0009158	57	0.139	Human
positive regulation of dna templated transcription elongation	GO:0032786	2	0.128
dna templated transcription initiation	GO:0006352	13	0.127	Yeast
regulation of protein maturation	GO:1903317	96	0.120
regulation of proteolysis	GO:0030162	164	0.120
regulation of cellular catabolic process	GO:0031329	242	0.117
binding of sperm to zona pellucida	GO:0007339	34	0.113
spindle organization	GO:0007051	28	0.113
purine ribonucleotide metabolic process	GO:0009150	290	0.109	Human
regulation of hydrolase activity	GO:0051336	246	0.108
single fertilization	GO:0007338	82	0.108
organelle assembly	GO:0070925	177	0.101
dna repair	GO:0006281	107	0.101
protein refolding	GO:0042026	1	0.099
protein import	GO:0017038	101	0.097
regulation of peptidase activity	GO:0052547	96	0.096
regulation of cell cycle process	GO:0010564	160	0.095
regulation of endopeptidase activity	GO:0052548	89	0.095
ribonucleoside triphosphate catabolic process	GO:0009203	199	0.095	Human
positive regulation of proteolysis	GO:0045862	85	0.094
purine nucleoside catabolic process	GO:0006152	205	0.090	Human
negative regulation of cellular protein metabolic process	GO:0032269	247	0.090
posttranscriptional regulation of gene expression	GO:0010608	155	0.086
rna polymerase ii transcriptional preinitiation complex assembly	GO:0051123	3	0.085	Yeast
maternal determination of anterior posterior axis embryo	GO:0008358	2	0.084
protein deubiquitination	GO:0016579	19	0.081
negative regulation of proteasomal ubiquitin dependent protein catabolic process	GO:0032435	15	0.081
protein ubiquitination	GO:0016567	171	0.080
purine nucleotide catabolic process	GO:0006195	211	0.080	Human
negative regulation of protein maturation	GO:1903318	79	0.079
purine ribonucleoside triphosphate metabolic process	GO:0009205	220	0.077	Human
positive regulation of transcription initiation from rna polymerase ii promoter	GO:0060261	5	0.077	Yeast
protein import into nucleus	GO:0006606	95	0.076
regulation of proteasomal ubiquitin dependent protein catabolic process	GO:0032434	40	0.075
pore complex assembly	GO:0046931	3	0.074
negative regulation of cell proliferation	GO:0008285	296	0.073
spermatogenesis	GO:0007283	284	0.073
purine ribonucleoside metabolic process	GO:0046128	241	0.073	Human
organophosphate catabolic process	GO:0046434	232	0.073	Human
protein localization to nucleus	GO:0034504	121	0.071
regulation of mitotic cell cycle phase transition	GO:1901990	73	0.067
chromatin organization	GO:0006325	206	0.067
cellular nitrogen compound catabolic process	GO:0044270	280	0.066	Human
regulation of protein processing	GO:0070613	96	0.062
oocyte construction	GO:0007308	2	0.061
spermatid differentiation	GO:0048515	115	0.060
nucleotide catabolic process	GO:0009166	217	0.060	Human
protein processing	GO:0016485	163	0.059
nuclear import	GO:0051170	95	0.059
cell division	GO:0051301	120	0.056
transcription elongation from rna polymerase ii promoter	GO:0006368	9	0.056
development of primary sexual characteristics	GO:0045137	143	0.055
regulation of proteasomal protein catabolic process	GO:0061136	46	0.054
positive regulation of endopeptidase activity	GO:0010950	43	0.053
negative regulation of protein catabolic process	GO:0042177	36	0.053
protein acylation	GO:0043543	64	0.051
regulation of protein modification by small protein conjugation or removal	GO:1903320	57	0.051
regulation of cellular protein catabolic process	GO:1903362	61	0.051
regulation of protein catabolic process	GO:0042176	108	0.051	Yeast
negative regulation of proteolysis	GO:0045861	74	0.050
intracellular protein transport	GO:0006886	204	0.048
oocyte anterior posterior axis specification	GO:0007314	2	0.048
regulation of protein targeting	GO:1903533	61	0.048
rna interference	GO:0016246	2	0.048
toxin transport	GO:1901998	38	0.048
male gamete generation	GO:0048232	285	0.048
cell cell recognition	GO:0009988	44	0.046
protein stabilization	GO:0050821	25	0.046
negative regulation of cellular protein catabolic process	GO:1903363	22	0.045
nuclear transport	GO:0051169	139	0.045
positive regulation of transcription elongation from rna polymerase ii promoter	GO:0032968	2	0.045
histone acetylation	GO:0016573	41	0.044
double strand break repair	GO:0006302	48	0.044
genitalia development	GO:0048806	37	0.044
heterocycle catabolic process	GO:0046700	280	0.043	Human
regulation of inclusion body assembly	GO:0090083	1	0.043
regulation of protein stability	GO:0031647	52	0.041
protein polymerization	GO:0051258	57	0.041
negative regulation of cell development	GO:0010721	169	0.041
positive regulation of peptidase activity	GO:0010952	49	0.041
chromatin modification	GO:0016568	187	0.040
protein maturation	GO:0051604	176	0.039
nucleoside triphosphate catabolic process	GO:0009143	205	0.039	Human
purine nucleoside monophosphate catabolic process	GO:0009128	58	0.038	Human
nucleobase containing small molecule metabolic process	GO:0055086	352	0.038	Human
transcription initiation from rna polymerase ii promoter	GO:0006367	8	0.038	Yeast
microtubule cytoskeleton organization	GO:0000226	157	0.038
regulation of cell cycle	GO:0051726	281	0.038
mitotic cytokinesis	GO:0000281	4	0.038
spindle assembly	GO:0051225	13	0.038
protein targeting	GO:0006605	143	0.037
regulation of mitotic cell cycle	GO:0007346	126	0.037
glycosyl compound metabolic process	GO:1901657	246	0.036	Human
mitotic spindle organization	GO:0007052	10	0.036
regulation of ion transmembrane transport	GO:0034765	119	0.036
dna recombination	GO:0006310	92	0.035
embryonic organ morphogenesis	GO:0048562	276	0.035
mapk cascade	GO:0000165	281	0.035
synaptic transmission	GO:0007268	329	0.034
establishment of protein localization to organelle	GO:0072594	118	0.034
regulation of transmembrane transport	GO:0034762	128	0.034
nucleoside monophosphate catabolic process	GO:0009125	59	0.034	Human
protein localization to organelle	GO:0033365	185	0.034
negative regulation of molecular function	GO:0044092	258	0.034
positive regulation of proteasomal ubiquitin dependent protein catabolic process	GO:0032436	23	0.034
atp catabolic process	GO:0006200	55	0.033	Human
protein dna complex subunit organization	GO:0071824	28	0.033	Yeast
molting cycle	GO:0042303	90	0.033
purine containing compound catabolic process	GO:0072523	213	0.032	Human
ribonucleoside triphosphate metabolic process	GO:0009199	220	0.032	Human
positive regulation of cell death	GO:0010942	224	0.031
organic cyclic compound catabolic process	GO:1901361	295	0.031	Human
purine nucleoside triphosphate catabolic process	GO:0009146	203	0.030	Human
oocyte axis specification	GO:0007309	2	0.030
transmembrane transport	GO:0055085	412	0.029
regulation of ion transport	GO:0043269	215	0.029
regulation of receptor activity	GO:0010469	41	0.029
regulation of intracellular transport	GO:0032386	159	0.028
microtubule based process	GO:0007017	236	0.028
chromosome segregation	GO:0007059	48	0.028
positive regulation of apoptotic process	GO:0043065	217	0.028
oocyte differentiation	GO:0009994	35	0.027
purine containing compound metabolic process	GO:0072521	311	0.026	Human
ribonucleotide catabolic process	GO:0009261	208	0.026	Human
regulation of cellular component biogenesis	GO:0044087	181	0.026	Yeast
nucleoside catabolic process	GO:0009164	206	0.026	Human
multicellular organismal aging	GO:0010259	24	0.026	Worm
positive regulation of cellular component biogenesis	GO:0044089	94	0.026	Yeast
response to organonitrogen compound	GO:0010243	246	0.025
regulation of cysteine type endopeptidase activity involved in apoptotic process	GO:0043281	62	0.025
sensory organ morphogenesis	GO:0090596	242	0.025
organic acid biosynthetic process	GO:0016053	86	0.025
purine nucleotide metabolic process	GO:0006163	302	0.025	Human
regulation of transcription initiation from rna polymerase ii promoter	GO:0060260	6	0.025	Yeast
positive regulation of protein modification process	GO:0031401	299	0.025
positive regulation of protein catabolic process	GO:0045732	60	0.024	Yeast
peptidyl amino acid modification	GO:0018193	336	0.024
positive regulation of cellular amino acid metabolic process	GO:0045764	3	0.024
regulation of chromosome organization	GO:0033044	83	0.024
regulation of establishment of protein localization	GO:0070201	181	0.024
sperm individualization	GO:0007291	1	0.024
determination of adult lifespan	GO:0008340	11	0.023	Worm
negative regulation of cellular catabolic process	GO:0031330	47	0.023
cell recognition	GO:0008037	83	0.023
internal protein amino acid acetylation	GO:0006475	42	0.023
ribonucleoside monophosphate metabolic process	GO:0009161	80	0.023	Human
positive regulation of proteolysis involved in cellular protein catabolic process	GO:1903052	31	0.023
regulation of cell cycle phase transition	GO:1901987	77	0.022
posttranscriptional gene silencing	GO:0016441	10	0.022
internal peptidyl lysine acetylation	GO:0018393	42	0.022
single organism nuclear import	GO:1902593	95	0.022
regulation of stem cell differentiation	GO:2000736	50	0.022
regulation of cysteine type endopeptidase activity	GO:2000116	65	0.022
blastocyst development	GO:0001824	80	0.022
cell maturation	GO:0048469	127	0.022
ribonucleoside metabolic process	GO:0009119	245	0.021	Human
regulation of anion transport	GO:0044070	27	0.021
photoreceptor cell development	GO:0042461	40	0.021
nucleoside phosphate metabolic process	GO:0006753	338	0.021	Human
carboxylic acid biosynthetic process	GO:0046394	86	0.020
positive regulation of protein phosphorylation	GO:0001934	242	0.020
negative regulation of protein processing	GO:0010955	79	0.020
inorganic cation transmembrane transport	GO:0098662	207	0.020
regulation of organ morphogenesis	GO:2000027	144	0.020
regulation of kinase activity	GO:0043549	249	0.020
single organism cell adhesion	GO:0098602	156	0.019
positive regulation of transferase activity	GO:0051347	167	0.019
negative regulation of cell cycle phase transition	GO:1901988	48	0.019
ribonucleotide metabolic process	GO:0009259	291	0.019	Human
regulation of protein complex assembly	GO:0043254	83	0.019	Yeast
nucleotide metabolic process	GO:0009117	332	0.019	Human
protein methylation	GO:0006479	81	0.019
positive regulation of cellular catabolic process	GO:0031331	148	0.019
single organismal cell cell adhesion	GO:0016337	131	0.019
regulation of protein ubiquitination	GO:0031396	52	0.019
aromatic compound catabolic process	GO:0019439	286	0.019	Human
purine ribonucleoside catabolic process	GO:0046130	205	0.019	Human
positive regulation of cellular protein catabolic process	GO:1903364	34	0.018
stem cell differentiation	GO:0048863	268	0.018
protein folding	GO:0006457	28	0.018
cation transmembrane transport	GO:0098655	266	0.018
positive regulation of programmed cell death	GO:0043068	218	0.018
purine ribonucleoside monophosphate catabolic process	GO:0009169	57	0.018	Human
dna integrity checkpoint	GO:0031570	28	0.017
negative regulation of mitotic cell cycle phase transition	GO:1901991	45	0.017
peptidyl lysine modification	GO:0018205	77	0.017
nucleoside triphosphate metabolic process	GO:0009141	230	0.017	Human
nucleoside phosphate catabolic process	GO:1901292	222	0.017	Human
ion transmembrane transport	GO:0034220	361	0.017
regulation of mitosis	GO:0007088	29	0.017
spermatid development	GO:0007286	108	0.017
regulation of phosphatidylcholine biosynthetic process	GO:2001245	2	0.017
embryonic axis specification	GO:0000578	30	0.017
regulation of cell division	GO:0051302	76	0.017
regulation of transferase activity	GO:0051338	263	0.017
regulation of protein kinase activity	GO:0045859	232	0.017
positive regulation of mapk cascade	GO:0043410	170	0.016
leukocyte migration	GO:0050900	124	0.016
stress activated mapk cascade	GO:0051403	80	0.016
purine ribonucleotide catabolic process	GO:0009154	208	0.016	Human
positive regulation of sequence specific dna binding transcription factor activity	GO:0051091	68	0.016
palate development	GO:0060021	76	0.016
purine ribonucleoside triphosphate catabolic process	GO:0009207	199	0.015	Human
carbohydrate derivative catabolic process	GO:1901136	231	0.015	Human
leukocyte proliferation	GO:0070661	172	0.015
locomotory behavior	GO:0007626	195	0.015
regulation of cellular amino acid metabolic process	GO:0006521	5	0.015
regulation of nuclear division	GO:0051783	56	0.015
developmental programmed cell death	GO:0010623	41	0.015
methylation	GO:0032259	134	0.015
axonogenesis	GO:0007409	274	0.015
negative regulation of phosphorylation	GO:0042326	166	0.015
negative regulation of mitotic cell cycle	GO:0045930	58	0.015
regulation of protein transport	GO:0051223	163	0.015
anion transport	GO:0006820	177	0.015
macromolecule methylation	GO:0043414	120	0.015
cytoplasmic transport	GO:0016482	234	0.014
negative regulation of endopeptidase activity	GO:0010951	44	0.014
regulation of sequence specific dna binding transcription factor activity	GO:0051090	106	0.014
germ cell development	GO:0007281	185	0.014
neural tube formation	GO:0001841	108	0.014
t cell proliferation	GO:0042098	120	0.014
positive regulation of rna polymerase ii transcriptional preinitiation complex assembly	GO:0045899	2	0.014	Yeast
peptidyl lysine acetylation	GO:0018394	45	0.014
negative regulation of cell cycle	GO:0045786	123	0.014
oogenesis	GO:0048477	56	0.014
regulation of protein localization to nucleus	GO:1900180	60	0.014
negative regulation of phosphorus metabolic process	GO:0010563	184	0.013
recombinational repair	GO:0000725	21	0.013
negative regulation of proteolysis involved in cellular protein catabolic process	GO:1903051	22	0.013
purine nucleoside monophosphate metabolic process	GO:0009126	81	0.013	Human
lateral inhibition	GO:0046331	1	0.013
nucleotide excision repair	GO:0006289	13	0.013
positive regulation of protein complex assembly	GO:0031334	45	0.013	Yeast
regulation of nucleocytoplasmic transport	GO:0046822	73	0.013
respiratory system development	GO:0060541	190	0.013
regulation of cell growth	GO:0001558	91	0.013
hematopoietic progenitor cell differentiation	GO:0002244	143	0.013
extracellular structure organization	GO:0043062	148	0.013
reactive oxygen species biosynthetic process	GO:1903409	8	0.013
regulation of intracellular protein transport	GO:0033157	82	0.013
oocyte development	GO:0048599	33	0.013
regulation of cytoplasmic transport	GO:1903649	112	0.013
chromosome separation	GO:0051304	14	0.013
gene silencing	GO:0016458	38	0.012
negative regulation of cellular component organization	GO:0051129	194	0.012
regulation of transporter activity	GO:0032409	57	0.012
cell cycle checkpoint	GO:0000075	47	0.012
glycosyl compound catabolic process	GO:1901658	206	0.012	Human
calcium ion transport	GO:0006816	159	0.012
regulation of body fluid levels	GO:0050878	162	0.012
regulation of inflammatory response	GO:0050727	147	0.012
dna damage checkpoint	GO:0000077	26	0.012
purine nucleoside triphosphate metabolic process	GO:0009144	226	0.012	Human
negative regulation of intracellular signal transduction	GO:1902532	167	0.012
positive regulation of cellular amine metabolic process	GO:0033240	5	0.012
protein alkylation	GO:0008213	81	0.012
rna splicing	GO:0008380	54	0.012
positive regulation of protein localization to nucleus	GO:1900182	30	0.012
organonitrogen compound catabolic process	GO:1901565	264	0.012	Human
regulation of dna templated transcription initiation	GO:2000142	7	0.012	Yeast
cytokinesis	GO:0000910	17	0.012
monocarboxylic acid biosynthetic process	GO:0072330	61	0.011
dephosphorylation	GO:0016311	129	0.011
double strand break repair via homologous recombination	GO:0000724	21	0.011
t cell activation	GO:0042110	289	0.011
cytoplasmic microtubule organization	GO:0031122	14	0.011
positive regulation of purine nucleotide catabolic process	GO:0033123	88	0.011
regulation of membrane potential	GO:0042391	192	0.011
regulation of epithelial cell proliferation	GO:0050678	141	0.011
cell fate commitment	GO:0045165	210	0.011
cellular response to organonitrogen compound	GO:0071417	145	0.011
forebrain development	GO:0030900	302	0.011
regulation of cellular ketone metabolic process	GO:0010565	66	0.011
cellular amine metabolic process	GO:0044106	44	0.011
regulation of protein binding	GO:0043393	60	0.011
gene silencing by rna	GO:0031047	19	0.011
er associated ubiquitin dependent protein catabolic process	GO:0030433	10	0.011
negative regulation of retinal cell programmed cell death	GO:0046671	2	0.011
dna templated transcription elongation	GO:0006354	13	0.011
negative regulation of cell cycle process	GO:0010948	69	0.011
epithelial cell proliferation	GO:0050673	174	0.011
positive regulation of dna templated transcription initiation	GO:2000144	5	0.011	Yeast
regulation of organelle organization	GO:0033043	289	0.011
embryonic eye morphogenesis	GO:0048048	29	0.010
cellular response to hormone stimulus	GO:0032870	150	0.010
inorganic ion transmembrane transport	GO:0098660	234	0.010
epithelial tube morphogenesis	GO:0060562	303	0.010
female gamete generation	GO:0007292	74	0.010
regionalization	GO:0003002	337	0.010
response to peptide hormone	GO:0043434	127	0.010
negative regulation of protein phosphorylation	GO:0001933	126	0.010
negative regulation of alcohol biosynthetic process	GO:1902931	4	0.010

Psmc2 disease predictions

Disease predictions are made from cross-annotation of human disease genes to the identified functional analogs in mouse and predicted with the mouse functional network.

Disease	DO term ID	Probability
nervous system disease	DOID:863	0.045
neuromuscular disease	DOID:440	0.045
disease of anatomical entity	DOID:7	0.045
neuropathy	DOID:870	0.045

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