IMP: Integrative Multi-species Prediction

Mus musculus

111 known processes

Smarca5

SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily a, member 5

(Aliases: MommeD4,4933427E24Rik,D330027N15Rik,Snf2h,D030040M08Rik)

Ensembl: ENSMUSG00000031715
Entrez: 93762
UniProtKB: Q91ZW3

Process Predictions
Disease Predictions

Smarca5 biological process predictions

Show only novel predictionsHighlight processes of functional analogs

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Biological process	GO term ID	Process size	Probability	Func Analog Org
heterochromatin organization	GO:0070828	4	0.967	Yeast
chromatin assembly or disassembly	GO:0006333	16	0.943
chromatin assembly	GO:0031497	13	0.936	Human Yeast Fly
protein dna complex subunit organization	GO:0071824	28	0.908	Human Yeast Fly
gene silencing	GO:0016458	38	0.885
heterochromatin assembly	GO:0031507	2	0.876
chromatin organization	GO:0006325	206	0.863
chromatin modification	GO:0016568	187	0.840
rna interference	GO:0016246	2	0.809	Worm
histone modification	GO:0016570	159	0.794
covalent chromatin modification	GO:0016569	163	0.748
gene silencing by rna	GO:0031047	19	0.720	Worm
nucleoside catabolic process	GO:0009164	206	0.685	Human Yeast Fly
regulation of chromosome organization	GO:0033044	83	0.653	Yeast
development of primary sexual characteristics	GO:0045137	143	0.549	Worm
regionalization	GO:0003002	337	0.520
atp catabolic process	GO:0006200	55	0.512	Human Yeast Fly
dna packaging	GO:0006323	30	0.498	Human Yeast Fly
regulation of chromatin modification	GO:1903308	57	0.485	Yeast
nucleosome assembly	GO:0006334	7	0.414	Human Fly
purine ribonucleoside metabolic process	GO:0046128	241	0.407	Human Yeast Fly
protein modification by small protein conjugation or removal	GO:0070647	207	0.396
purine ribonucleoside triphosphate catabolic process	GO:0009207	199	0.370	Human Yeast Fly
organonitrogen compound catabolic process	GO:1901565	264	0.368	Human Yeast Fly
posttranscriptional gene silencing by rna	GO:0035194	10	0.353	Worm
mitotic cell cycle	GO:0000278	195	0.342
purine ribonucleotide catabolic process	GO:0009154	208	0.320	Human Yeast Fly
nucleobase containing small molecule metabolic process	GO:0055086	352	0.317	Human Yeast Fly
regulation of apoptotic signaling pathway	GO:2001233	197	0.305
protein acylation	GO:0043543	64	0.298
dna conformation change	GO:0071103	37	0.281	Human Yeast Fly
dna metabolic process	GO:0006259	303	0.272
mitotic cell cycle process	GO:1903047	159	0.248
cellular response to dna damage stimulus	GO:0006974	207	0.234
purine nucleotide catabolic process	GO:0006195	211	0.233	Human Yeast Fly
purine nucleoside triphosphate catabolic process	GO:0009146	203	0.211	Human Yeast Fly
nucleoside metabolic process	GO:0009116	246	0.210	Human Yeast Fly
organophosphate catabolic process	GO:0046434	232	0.209	Human Yeast Fly
oocyte axis specification	GO:0007309	2	0.200
purine ribonucleoside monophosphate metabolic process	GO:0009167	80	0.196	Human Yeast Fly
nucleoside monophosphate catabolic process	GO:0009125	59	0.182	Human Yeast Fly
regulation of cell cycle	GO:0051726	281	0.161
purine nucleotide metabolic process	GO:0006163	302	0.160	Human Yeast Fly
developmental maturation	GO:0021700	193	0.160
purine containing compound metabolic process	GO:0072521	311	0.157	Human Yeast Fly
ribonucleotide metabolic process	GO:0009259	291	0.155	Human Yeast Fly
chromatin remodeling	GO:0006338	32	0.154
ribose phosphate metabolic process	GO:0019693	291	0.150	Human Yeast Fly
organic cyclic compound catabolic process	GO:1901361	295	0.149	Human Yeast Fly
regulation of cell cycle process	GO:0010564	160	0.145
cell maturation	GO:0048469	127	0.143
regulation of cellular component biogenesis	GO:0044087	181	0.142	Yeast
glycosyl compound metabolic process	GO:1901657	246	0.141	Human Yeast Fly
segmentation	GO:0035282	93	0.139
nucleoside phosphate metabolic process	GO:0006753	338	0.138	Human Yeast Fly
response to organic cyclic compound	GO:0014070	198	0.136	Fly
posttranscriptional regulation of gene expression	GO:0010608	155	0.129	Worm
nucleoside monophosphate metabolic process	GO:0009123	85	0.128	Human Yeast Fly
negative regulation of molecular function	GO:0044092	258	0.126
glycosyl compound catabolic process	GO:1901658	206	0.125	Human Yeast Fly
protein methylation	GO:0006479	81	0.125
histone acetylation	GO:0016573	41	0.122
carbohydrate derivative catabolic process	GO:1901136	231	0.120	Human Yeast Fly
nucleoside triphosphate catabolic process	GO:0009143	205	0.117	Human Yeast Fly
germ cell development	GO:0007281	185	0.115
meiotic nuclear division	GO:0007126	115	0.114
purine containing compound catabolic process	GO:0072523	213	0.113	Human Yeast Fly
skin development	GO:0043588	220	0.108
rna processing	GO:0006396	105	0.105
oocyte construction	GO:0007308	2	0.101
protein modification by small protein removal	GO:0070646	21	0.101
apoptotic signaling pathway	GO:0097190	306	0.101
regulation of organelle organization	GO:0033043	289	0.099	Yeast
regulation of circadian rhythm	GO:0042752	58	0.098	Fly
regulation of protein stability	GO:0031647	52	0.096
purine nucleoside catabolic process	GO:0006152	205	0.096	Human Yeast Fly
dna replication	GO:0006260	52	0.092
oogenesis	GO:0048477	56	0.091
regulation of chromatin organization	GO:1902275	57	0.088	Yeast
purine ribonucleoside catabolic process	GO:0046130	205	0.088	Human Yeast Fly
gonad development	GO:0008406	141	0.083	Worm
heterocycle catabolic process	GO:0046700	280	0.079	Human Yeast Fly
stem cell maintenance	GO:0019827	130	0.079
negative regulation of protein metabolic process	GO:0051248	282	0.078
organelle fission	GO:0048285	170	0.075
circadian rhythm	GO:0007623	114	0.075	Fly
ossification	GO:0001503	216	0.072
n terminal protein amino acid modification	GO:0031365	6	0.071
cellular amine metabolic process	GO:0044106	44	0.070
meiotic cell cycle process	GO:1903046	77	0.070
protein modification by small protein conjugation	GO:0032446	187	0.069
forebrain development	GO:0030900	302	0.068
ribonucleoprotein complex disassembly	GO:0032988	3	0.067
regulation of nucleoside metabolic process	GO:0009118	130	0.065
purine ribonucleoside triphosphate metabolic process	GO:0009205	220	0.065	Human Yeast Fly
g1 s transition of mitotic cell cycle	GO:0000082	57	0.063
compound eye development	GO:0048749	1	0.062
ribonucleotide catabolic process	GO:0009261	208	0.061	Human Yeast Fly
dendrite development	GO:0016358	115	0.061	Fly
ribonucleoside triphosphate catabolic process	GO:0009203	199	0.059	Human Yeast Fly
multi multicellular organism process	GO:0044706	109	0.059
purine nucleoside metabolic process	GO:0042278	241	0.058	Human Yeast Fly
regulation of nucleotide metabolic process	GO:0006140	169	0.058
cellular amino acid metabolic process	GO:0006520	103	0.056
nuclear division	GO:0000280	158	0.056
ribonucleoside monophosphate catabolic process	GO:0009158	57	0.056	Human Yeast Fly
epidermis development	GO:0008544	187	0.055
female gamete generation	GO:0007292	74	0.054
skeletal system development	GO:0001501	356	0.051
leukocyte differentiation	GO:0002521	342	0.051
positive regulation of growth	GO:0045927	104	0.050
meiotic cell cycle	GO:0051321	122	0.050
dna alkylation	GO:0006305	43	0.049
cell cycle g1 s phase transition	GO:0044843	57	0.049
stem cell development	GO:0048864	219	0.049
regulation of neuron projection development	GO:0010975	169	0.048
ribonucleoside metabolic process	GO:0009119	245	0.047	Human Yeast Fly
protein localization to nucleus	GO:0034504	121	0.047
embryonic skeletal system development	GO:0048706	120	0.047
organelle assembly	GO:0070925	177	0.047
regulation of cell projection organization	GO:0031344	206	0.046
spermatogenesis	GO:0007283	284	0.045
ras protein signal transduction	GO:0007265	77	0.045
regulation of cell cycle phase transition	GO:1901987	77	0.045
blastocyst development	GO:0001824	80	0.045
cellular ketone metabolic process	GO:0042180	84	0.044
nucleotide metabolic process	GO:0009117	332	0.044	Human Yeast Fly
rna splicing	GO:0008380	54	0.043
ribonucleoprotein complex subunit organization	GO:0071826	28	0.043
regulation of protein complex assembly	GO:0043254	83	0.043	Yeast
peptidyl lysine modification	GO:0018205	77	0.042
protein refolding	GO:0042026	1	0.042
regulation of cell activation	GO:0050865	289	0.042
protein stabilization	GO:0050821	25	0.042
regulation of mitotic cell cycle phase transition	GO:1901990	73	0.042
male gamete generation	GO:0048232	285	0.042
positive regulation of cell activation	GO:0050867	158	0.041
determination of adult lifespan	GO:0008340	11	0.041	Worm
establishment of protein localization to organelle	GO:0072594	118	0.041
response to organonitrogen compound	GO:0010243	246	0.040
regulation of purine nucleotide catabolic process	GO:0033121	122	0.040
embryonic skeletal system morphogenesis	GO:0048704	91	0.040
regulation of rna polymerase ii transcriptional preinitiation complex assembly	GO:0045898	2	0.039
adaptive immune response based on somatic recombination of immune receptors built from immunoglobulin superfamily domains	GO:0002460	145	0.039
methylation	GO:0032259	134	0.039
negative regulation of apoptotic signaling pathway	GO:2001234	104	0.038
positive regulation of cell cycle phase transition	GO:1901989	17	0.037
macromolecule methylation	GO:0043414	120	0.037
multicellular organism growth	GO:0035264	161	0.037
microtubule based process	GO:0007017	236	0.037
oocyte development	GO:0048599	33	0.036
negative regulation of cellular protein metabolic process	GO:0032269	247	0.036
negative regulation of cell projection organization	GO:0031345	56	0.036
rna splicing via transesterification reactions	GO:0000375	43	0.035
ribonucleoside triphosphate metabolic process	GO:0009199	220	0.035	Human Yeast Fly
circulatory system process	GO:0003013	197	0.035
protein ubiquitination	GO:0016567	171	0.034
nucleoside triphosphate metabolic process	GO:0009141	230	0.034	Human Yeast Fly
aromatic compound catabolic process	GO:0019439	286	0.034	Human Yeast Fly
response to radiation	GO:0009314	165	0.034
regulation of cell division	GO:0051302	76	0.033
internal protein amino acid acetylation	GO:0006475	42	0.033
rna 3 end processing	GO:0031123	20	0.033
positive regulation of nfat protein import into nucleus	GO:0051533	1	0.033
translation	GO:0006412	93	0.033
negative regulation of neuron projection development	GO:0010977	50	0.033
positive regulation of mitotic cell cycle phase transition	GO:1901992	17	0.033
secretory granule organization	GO:0033363	20	0.032
regulation of mrna processing	GO:0050684	41	0.032
mrna localization resulting in posttranscriptional regulation of gene expression	GO:0010609	2	0.032
axonogenesis	GO:0007409	274	0.032
cell division	GO:0051301	120	0.031
regulation of neuron differentiation	GO:0045664	281	0.030
respiratory system development	GO:0060541	190	0.030
posttranscriptional gene silencing	GO:0016441	10	0.029	Worm
nuclear import	GO:0051170	95	0.029
regulation of leukocyte differentiation	GO:1902105	159	0.028
chromatin silencing	GO:0006342	15	0.028
ribonucleoside catabolic process	GO:0042454	206	0.028	Human Yeast Fly
peptidyl amino acid modification	GO:0018193	336	0.028
negative regulation of neuron differentiation	GO:0045665	101	0.027
germ cell proliferation	GO:0036093	7	0.027
adult behavior	GO:0030534	135	0.027
regulation of meiotic cell cycle	GO:0051445	34	0.026
positive regulation of cell cycle process	GO:0090068	61	0.026
striated muscle tissue development	GO:0014706	293	0.026
neural tube development	GO:0021915	160	0.026
muscle tissue development	GO:0060537	308	0.025
dna modification	GO:0006304	50	0.025
protein alkylation	GO:0008213	81	0.024
pallium development	GO:0021543	120	0.024
skeletal system morphogenesis	GO:0048705	203	0.024
embryonic organ morphogenesis	GO:0048562	276	0.024
mapk cascade	GO:0000165	281	0.023
muscle cell differentiation	GO:0042692	261	0.023
single fertilization	GO:0007338	82	0.023
regulation of cellular catabolic process	GO:0031329	242	0.022
microtubule cytoskeleton organization	GO:0000226	157	0.022
amine metabolic process	GO:0009308	45	0.022
regulation of kinase activity	GO:0043549	249	0.022
regulation of hydrolase activity	GO:0051336	246	0.022
response to light stimulus	GO:0009416	135	0.022
developmental growth involved in morphogenesis	GO:0060560	138	0.022
multi organism reproductive behavior	GO:0044705	29	0.022
stem cell differentiation	GO:0048863	268	0.022
maintenance of protein location in nucleus	GO:0051457	2	0.022
muscle cell development	GO:0055001	133	0.021
atp metabolic process	GO:0046034	75	0.021	Human Yeast Fly
regulation of intrinsic apoptotic signaling pathway	GO:2001242	61	0.021
positive regulation of cell cycle	GO:0045787	92	0.021
angiogenesis	GO:0001525	201	0.021
negative regulation of protein processing	GO:0010955	79	0.021
mrna transport	GO:0051028	13	0.021
protein localization to organelle	GO:0033365	185	0.021
gastrulation	GO:0007369	116	0.021
regulation of mrna splicing via spliceosome	GO:0048024	32	0.021
small gtpase mediated signal transduction	GO:0007264	97	0.021
regulation of transcription by chromatin organization	GO:0034401	0	0.021	Yeast
ear development	GO:0043583	200	0.020
ribosomal small subunit biogenesis	GO:0042274	4	0.020
intracellular mrna localization	GO:0008298	4	0.020
spliceosomal complex assembly	GO:0000245	6	0.020
negative regulation of cellular component organization	GO:0051129	194	0.019	Yeast
spermatid development	GO:0007286	108	0.019
purine ribonucleotide metabolic process	GO:0009150	290	0.019	Human Yeast Fly
regulation of protein transport	GO:0051223	163	0.019
cell fate commitment	GO:0045165	210	0.019
b cell activation	GO:0042113	161	0.018
positive regulation of dna templated transcription initiation	GO:2000144	5	0.018
regulation of nuclear division	GO:0051783	56	0.018
memory	GO:0007613	58	0.018
regulation of nucleotide catabolic process	GO:0030811	122	0.018
dna repair	GO:0006281	107	0.017
protein import	GO:0017038	101	0.017
locomotory behavior	GO:0007626	195	0.017
negative regulation of translation	GO:0017148	22	0.017
spliceosomal complex disassembly	GO:0000390	1	0.017
blood circulation	GO:0008015	195	0.017
innate immune response	GO:0045087	157	0.017
negative regulation of cell cycle	GO:0045786	123	0.017
histone deacetylation	GO:0016575	26	0.017
rna phosphodiester bond hydrolysis exonucleolytic	GO:0090503	4	0.017
sister chromatid segregation	GO:0000819	20	0.017
chromosome organization involved in meiosis	GO:0070192	39	0.017
sensory perception	GO:0007600	245	0.017
positive regulation of apoptotic signaling pathway	GO:2001235	95	0.017
cellular response to inorganic substance	GO:0071241	37	0.017
regulation of cellular component size	GO:0032535	121	0.017
genitalia development	GO:0048806	37	0.017	Worm
regulation of chromatin binding	GO:0035561	7	0.017
skeletal muscle organ development	GO:0060538	163	0.016
cellular response to growth factor stimulus	GO:0071363	197	0.016
protein targeting	GO:0006605	143	0.016
myeloid cell differentiation	GO:0030099	233	0.016
regulation of lymphocyte activation	GO:0051249	240	0.016
nucleus organization	GO:0006997	45	0.016	Fly
spermatid differentiation	GO:0048515	115	0.016
positive regulation of mitotic cell cycle	GO:0045931	41	0.016
multicellular organismal reproductive behavior	GO:0033057	23	0.016
negative regulation of cell cycle phase transition	GO:1901988	48	0.016
chromatin mediated maintenance of transcription	GO:0048096	2	0.016
negative regulation of phosphate metabolic process	GO:0045936	184	0.015
positive regulation of cellular component biogenesis	GO:0044089	94	0.015
neuron migration	GO:0001764	122	0.015
nucleoside phosphate catabolic process	GO:1901292	222	0.015	Human Yeast Fly
regulation of response to wounding	GO:1903034	189	0.015
protein deacylation	GO:0035601	36	0.015
regulation of cellular amine metabolic process	GO:0033238	20	0.015
muscle contraction	GO:0006936	101	0.015
axon guidance	GO:0007411	141	0.014
mrna processing	GO:0006397	63	0.014
regulation of peptidase activity	GO:0052547	96	0.014
cellular macromolecule catabolic process	GO:0044265	206	0.014
hindbrain development	GO:0030902	128	0.014
neuron maturation	GO:0042551	29	0.014
respiratory tube development	GO:0030323	167	0.014
histone ubiquitination	GO:0016574	10	0.014
cell type specific apoptotic process	GO:0097285	268	0.014
membrane organization	GO:0061024	245	0.014
regulation of myeloid cell differentiation	GO:0045637	96	0.014
mitotic sister chromatid segregation	GO:0000070	14	0.014
regulation of hormone levels	GO:0010817	211	0.014
response to oxidative stress	GO:0006979	123	0.013
purine ribonucleoside monophosphate catabolic process	GO:0009169	57	0.013	Human Yeast Fly
protein import into nucleus	GO:0006606	95	0.013
central nervous system neuron differentiation	GO:0021953	162	0.013
organelle localization	GO:0051640	179	0.013
dna templated transcriptional preinitiation complex assembly	GO:0070897	4	0.013
regulation of rna splicing	GO:0043484	37	0.013
cajal body organization	GO:0030576	1	0.013
regulation of embryonic development	GO:0045995	71	0.013
positive regulation of cell death	GO:0010942	224	0.013
regulation of mitotic cell cycle	GO:0007346	126	0.013
negative regulation of mitotic cell cycle	GO:0045930	58	0.013
regulation of histone acetylation	GO:0035065	19	0.013
positive regulation of apoptotic process	GO:0043065	217	0.013
histone monoubiquitination	GO:0010390	3	0.013
regulation of binding	GO:0051098	111	0.013
lymphocyte differentiation	GO:0030098	242	0.013
histone lysine methylation	GO:0034968	50	0.013
regulation of protein maturation	GO:1903317	96	0.012
negative regulation of intracellular signal transduction	GO:1902532	167	0.012
lateral inhibition	GO:0046331	1	0.012
fertilization	GO:0009566	127	0.012
cytoplasmic transport	GO:0016482	234	0.012
positive regulation of osteoclast differentiation	GO:0045672	15	0.012
nucleotide catabolic process	GO:0009166	217	0.012	Human Yeast Fly
positive regulation of programmed cell death	GO:0043068	218	0.012
stem cell division	GO:0017145	30	0.012
mrna splice site selection	GO:0006376	5	0.012
cellular response to oxidative stress	GO:0034599	76	0.012
negative regulation of dna replication	GO:0008156	4	0.012
myosin filament organization	GO:0031033	3	0.012
cleavage involved in rrna processing	GO:0000469	1	0.012
male meiosis	GO:0007140	37	0.012
mesenchyme development	GO:0060485	152	0.011
fat cell differentiation	GO:0045444	160	0.011
negative regulation of binding	GO:0051100	39	0.011
limb development	GO:0060173	166	0.011
cognition	GO:0050890	149	0.011
appendage morphogenesis	GO:0035107	149	0.011
maturation of ssu rrna from tricistronic rrna transcript ssu rrna 5 8s rrna lsu rrna	GO:0000462	1	0.011
regulation of atp metabolic process	GO:1903578	17	0.011
mrna metabolic process	GO:0016071	84	0.011
maintenance of location	GO:0051235	89	0.011
mitotic spindle organization	GO:0007052	10	0.011
negative regulation of protein modification process	GO:0031400	163	0.011
kinetochore organization	GO:0051383	2	0.011
multi organism behavior	GO:0051705	62	0.011
maternal determination of anterior posterior axis embryo	GO:0008358	2	0.011
nucleus localization	GO:0051647	20	0.010
dna dependent dna replication	GO:0006261	24	0.010
purine nucleoside monophosphate metabolic process	GO:0009126	81	0.010	Human Yeast Fly
response to transforming growth factor beta	GO:0071559	88	0.010
protein processing	GO:0016485	163	0.010
gland development	GO:0048732	330	0.010
regulation of adaptive immune response	GO:0002819	90	0.010
positive regulation of mrna metabolic process	GO:1903313	17	0.010

Smarca5 disease predictions

Disease predictions are made from cross-annotation of human disease genes to the identified functional analogs in mouse and predicted with the mouse functional network.

Disease	DO term ID	Probability
nervous system disease	DOID:863	0.031
disease of anatomical entity	DOID:7	0.031
eye and adnexa disease	DOID:1492	0.016
eye disease	DOID:5614	0.016
sensory system disease	DOID:0050155	0.016

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