IMP: Integrative Multi-species Prediction

Mus musculus

123 known processes

Il22

interleukin 22

(Aliases: IL-22a,IL-22,Iltif,MGC129417,MGC129416,ILTIFa)

Entrez: 50929
Ensembl: ENSMUSG00000074695
UniProtKB: Q9JJY9

Process Predictions
Disease Predictions

Il22 biological process predictions

Show only novel predictionsHighlight processes of functional analogs

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Biological process	GO term ID	Process size	Probability	Func Analog Org
cellular response to lipid	GO:0071396	145	0.498	Mouse
cytokine production	GO:0001816	319	0.480	Mouse
regulation of inflammatory response to antigenic stimulus	GO:0002861	21	0.308	Mouse
positive regulation of protein phosphorylation	GO:0001934	242	0.297
activation of immune response	GO:0002253	138	0.296
immunoglobulin mediated immune response	GO:0016064	69	0.292
cellular amino acid metabolic process	GO:0006520	103	0.281
cellular response to lipopolysaccharide	GO:0071222	77	0.270	Mouse
adaptive immune response based on somatic recombination of immune receptors built from immunoglobulin superfamily domains	GO:0002460	145	0.266
positive regulation of production of molecular mediator of immune response	GO:0002702	45	0.255
regulation of protein kinase activity	GO:0045859	232	0.226
regulation of ion transport	GO:0043269	215	0.225
humoral immune response	GO:0006959	57	0.221
regulation of protein serine threonine kinase activity	GO:0071900	157	0.219
t cell activation	GO:0042110	289	0.218
regulation of t cell activation	GO:0050863	170	0.198
regulation of defense response	GO:0031347	233	0.198
regulation of apoptotic signaling pathway	GO:2001233	197	0.197	Mouse
regulation of response to wounding	GO:1903034	189	0.193
dna metabolic process	GO:0006259	303	0.188
somatic diversification of immune receptors	GO:0002200	53	0.185
i kappab kinase nf kappab signaling	GO:0007249	85	0.184
regulation of sequence specific dna binding transcription factor activity	GO:0051090	106	0.183
chemotaxis	GO:0006935	247	0.181
apoptotic signaling pathway	GO:0097190	306	0.181	Mouse
reactive oxygen species metabolic process	GO:0072593	84	0.173
response to lipopolysaccharide	GO:0032496	128	0.173	Mouse
regulation of growth of symbiont in host	GO:0044126	19	0.171	Mouse
myeloid cell differentiation	GO:0030099	233	0.170
positive regulation of protein modification process	GO:0031401	299	0.169
organic acid transport	GO:0015849	101	0.167
regulation of proteolysis	GO:0030162	164	0.163	Mouse
regulation of protein transport	GO:0051223	163	0.162
protein maturation	GO:0051604	176	0.161	Mouse
regulation of erk1 and erk2 cascade	GO:0070372	71	0.160
erk1 and erk2 cascade	GO:0070371	77	0.157
regulation of lymphocyte activation	GO:0051249	240	0.154
regulation of interleukin 10 secretion	GO:2001179	4	0.148
regulation of cellular amine metabolic process	GO:0033238	20	0.145
zymogen activation	GO:0031638	41	0.143
activation of cysteine type endopeptidase activity	GO:0097202	27	0.142
negative regulation of cell activation	GO:0050866	111	0.141	Mouse
leukocyte mediated immunity	GO:0002443	174	0.141
sensory perception	GO:0007600	245	0.139
cellular response to cytokine stimulus	GO:0071345	189	0.139
response to molecule of bacterial origin	GO:0002237	143	0.139	Mouse
regulation of extrinsic apoptotic signaling pathway	GO:2001236	77	0.137	Mouse
regulation of secretion	GO:0051046	274	0.133
cellular chemical homeostasis	GO:0055082	215	0.131
dna recombination	GO:0006310	92	0.130
cytokine mediated signaling pathway	GO:0019221	115	0.130
peptide transport	GO:0015833	133	0.130
regulation of secretion by cell	GO:1903530	249	0.129
regulation of lymphocyte mediated immunity	GO:0002706	84	0.128
regulation of peptidase activity	GO:0052547	96	0.128	Mouse
protein processing	GO:0016485	163	0.127	Mouse
regulation of interferon gamma production	GO:0032649	57	0.126	Mouse
negative regulation of molecular function	GO:0044092	258	0.124	Mouse
leukocyte differentiation	GO:0002521	342	0.123
regulation of transferase activity	GO:0051338	263	0.122
positive regulation of proteolysis	GO:0045862	85	0.122	Mouse
leukocyte proliferation	GO:0070661	172	0.121
regulation of mapk cascade	GO:0043408	248	0.121
cell type specific apoptotic process	GO:0097285	268	0.121
regulation of acute inflammatory response	GO:0002673	27	0.119
carbohydrate metabolic process	GO:0005975	230	0.119
regulation of hormone secretion	GO:0046883	88	0.118
regulation of adaptive immune response based on somatic recombination of immune receptors built from immunoglobulin superfamily domains	GO:0002822	87	0.118
cytokine biosynthetic process	GO:0042089	68	0.118	Mouse
positive regulation of protein kinase activity	GO:0045860	144	0.117
regulation of hormone levels	GO:0010817	211	0.116
cation homeostasis	GO:0055080	212	0.115
negative regulation of t cell proliferation	GO:0042130	38	0.115
regulation of homeostatic process	GO:0032844	182	0.114
regulation of interleukin 18 production	GO:0032661	3	0.113
negative regulation of apoptotic signaling pathway	GO:2001234	104	0.113	Mouse
production of molecular mediator of immune response	GO:0002440	103	0.113
positive regulation of cellular amino acid metabolic process	GO:0045764	3	0.112
regulation of kinase activity	GO:0043549	249	0.112
positive regulation of lymphocyte activation	GO:0051251	140	0.112
activation of mapk activity	GO:0000187	59	0.112
positive regulation of hydrolase activity	GO:0051345	148	0.111	Mouse
cellular lipid metabolic process	GO:0044255	323	0.111
cellular ketone metabolic process	GO:0042180	84	0.110
positive regulation of peptidase activity	GO:0010952	49	0.109	Mouse
regulation of cytokine production	GO:0001817	266	0.109	Mouse
epithelial cell proliferation	GO:0050673	174	0.107
blood vessel morphogenesis	GO:0048514	285	0.106
regulation of b cell mediated immunity	GO:0002712	37	0.106
multicellular organismal homeostasis	GO:0048871	164	0.106
defense response to other organism	GO:0098542	197	0.105	Zebrafish Mouse
positive regulation of defense response	GO:0031349	124	0.105
cellular response to dna damage stimulus	GO:0006974	207	0.105
immune response activating signal transduction	GO:0002757	116	0.104
response to amino acid	GO:0043200	37	0.103
regulation of innate immune response	GO:0045088	91	0.103
cellular amine metabolic process	GO:0044106	44	0.103
regulation of cellular amino acid metabolic process	GO:0006521	5	0.102
positive regulation of endopeptidase activity	GO:0010950	43	0.100	Mouse
anion transport	GO:0006820	177	0.100
adaptive immune response	GO:0002250	155	0.099
response to acid chemical	GO:0001101	111	0.099
b cell activation involved in immune response	GO:0002312	50	0.099
negative regulation of hydrolase activity	GO:0051346	71	0.098	Mouse
regulation of adaptive immune response	GO:0002819	90	0.098
regulation of protein processing	GO:0070613	96	0.098	Mouse
antibacterial peptide biosynthetic process	GO:0002780	2	0.098
intracellular protein transport	GO:0006886	204	0.097
positive regulation of secretion	GO:0051047	130	0.097
organic anion transport	GO:0015711	137	0.096
regulation of body fluid levels	GO:0050878	162	0.096
transmembrane receptor protein tyrosine kinase signaling pathway	GO:0007169	247	0.096
growth of symbiont in host	GO:0044117	23	0.096	Mouse
engulfment of apoptotic cell	GO:0043652	3	0.096
regulation of inflammatory response	GO:0050727	147	0.095
divalent inorganic cation homeostasis	GO:0072507	138	0.095
positive regulation of b cell mediated immunity	GO:0002714	26	0.095
regulation of establishment of protein localization	GO:0070201	181	0.094
positive regulation of t cell activation	GO:0050870	101	0.092
interleukin 6 production	GO:0032635	58	0.092	Mouse
lymphocyte proliferation	GO:0046651	164	0.091
antibacterial peptide production	GO:0002778	2	0.090
regulation of cell adhesion	GO:0030155	154	0.090
negative regulation of inflammatory response to antigenic stimulus	GO:0002862	10	0.089	Mouse
regulation of interleukin 6 production	GO:0032675	55	0.089
cellular homeostasis	GO:0019725	240	0.088
positive regulation of apoptotic signaling pathway	GO:2001235	95	0.088	Mouse
striated muscle tissue development	GO:0014706	293	0.088
mapk cascade	GO:0000165	281	0.088
gland development	GO:0048732	330	0.088
peptidyl tyrosine modification	GO:0018212	145	0.087
regulation of membrane potential	GO:0042391	192	0.087
nitrogen compound transport	GO:0071705	271	0.087
interferon gamma production	GO:0032609	67	0.086	Mouse
regulation of cell activation	GO:0050865	289	0.086	Mouse
cytokine secretion	GO:0050663	72	0.086
cytoplasmic transport	GO:0016482	234	0.086
metal ion homeostasis	GO:0055065	189	0.086
myeloid leukocyte differentiation	GO:0002573	119	0.086
inflammatory response	GO:0006954	244	0.085
regulation of leukocyte proliferation	GO:0070663	121	0.085
regulation of endopeptidase activity	GO:0052548	89	0.085	Mouse
negative regulation of phosphate metabolic process	GO:0045936	184	0.085
regulation of prostaglandin endoperoxide synthase activity	GO:0060584	2	0.084
regulation of cell cycle	GO:0051726	281	0.084
positive regulation of mapk cascade	GO:0043410	170	0.084
negative regulation of response to wounding	GO:1903035	77	0.083
positive regulation of map kinase activity	GO:0043406	84	0.083
phagocytosis	GO:0006909	66	0.083
regulation of nucleocytoplasmic transport	GO:0046822	73	0.083
transmembrane transport	GO:0055085	412	0.083
regulation of t cell proliferation	GO:0042129	92	0.083
regulation of leukocyte mediated immunity	GO:0002703	104	0.082
epithelial tube morphogenesis	GO:0060562	303	0.082
action potential	GO:0001508	78	0.082
skeletal system development	GO:0001501	356	0.082
negative regulation of immune system process	GO:0002683	209	0.081	Mouse
regulation of cysteine type endopeptidase activity	GO:2000116	65	0.081	Mouse
protein kinase b signaling	GO:0043491	74	0.081
humoral immune response mediated by circulating immunoglobulin	GO:0002455	14	0.080
positive regulation of cysteine type endopeptidase activity involved in apoptotic process	GO:0043280	36	0.080	Mouse
positive regulation of behavior	GO:0048520	40	0.080
leukocyte activation involved in immune response	GO:0002366	126	0.079
regulation of antimicrobial humoral response	GO:0002759	3	0.079
digestive system development	GO:0055123	200	0.079
multicellular organismal signaling	GO:0035637	91	0.079
positive regulation of cell activation	GO:0050867	158	0.079
regulation of chronic inflammatory response to antigenic stimulus	GO:0002874	3	0.078	Mouse
regulation of chemotaxis	GO:0050920	53	0.077
intrinsic apoptotic signaling pathway	GO:0097193	132	0.077	Mouse
neuron apoptotic process	GO:0051402	142	0.077
oxidation reduction process	GO:0055114	342	0.077
positive regulation of apoptotic process	GO:0043065	217	0.076	Mouse
developmental maturation	GO:0021700	193	0.076
muscle system process	GO:0003012	141	0.075
negative regulation of adaptive immune response	GO:0002820	25	0.075
regulation of myeloid leukocyte differentiation	GO:0002761	58	0.074
amide transport	GO:0042886	138	0.074
tumor necrosis factor mediated signaling pathway	GO:0033209	13	0.074
response to oxidative stress	GO:0006979	123	0.074
negative regulation of nik nf kappab signaling	GO:1901223	2	0.073
antibacterial humoral response	GO:0019731	8	0.071
regulation of cell motility	GO:2000145	236	0.071
interleukin 10 secretion	GO:0072608	4	0.071
hormone secretion	GO:0046879	128	0.071
protein secretion	GO:0009306	111	0.070
transmission of nerve impulse	GO:0019226	76	0.070
t cell proliferation	GO:0042098	120	0.070
cellular divalent inorganic cation homeostasis	GO:0072503	127	0.070
positive regulation of myeloid leukocyte differentiation	GO:0002763	26	0.068
negative regulation of homeostatic process	GO:0032845	71	0.068
lymphocyte activation involved in immune response	GO:0002285	93	0.068
positive regulation of nervous system development	GO:0051962	221	0.067
positive regulation of cell development	GO:0010720	237	0.067
nuclear transport	GO:0051169	139	0.067
positive regulation of cell death	GO:0010942	224	0.067	Mouse
stem cell differentiation	GO:0048863	268	0.067
cellular response to acid chemical	GO:0071229	68	0.066
lymphocyte migration	GO:0072676	26	0.066
lipid localization	GO:0010876	126	0.066
positive regulation of programmed cell death	GO:0043068	218	0.065	Mouse
epidermis development	GO:0008544	187	0.065
regulation of cell migration	GO:0030334	219	0.065
t cell receptor signaling pathway	GO:0050852	46	0.065
inflammatory response to antigenic stimulus	GO:0002437	30	0.065	Mouse
negative regulation of inflammatory response	GO:0050728	61	0.064
muscle cell differentiation	GO:0042692	261	0.064
negative regulation of cellular protein metabolic process	GO:0032269	247	0.064	Mouse
cellular response to external stimulus	GO:0071496	88	0.064
defense response to bacterium	GO:0042742	119	0.064	Zebrafish Mouse
morphogenesis of a branching structure	GO:0001763	203	0.063	Mouse
t cell differentiation	GO:0030217	174	0.063
cation transport	GO:0006812	399	0.063
negative regulation of mapk cascade	GO:0043409	65	0.063
cellular calcium ion homeostasis	GO:0006874	119	0.063
hair cycle	GO:0042633	90	0.063
negative regulation of erk1 and erk2 cascade	GO:0070373	21	0.063
placenta development	GO:0001890	140	0.062	Mouse
tissue homeostasis	GO:0001894	115	0.062
negative regulation of lymphocyte proliferation	GO:0050672	45	0.062
homeostasis of number of cells	GO:0048872	210	0.062
chronic inflammatory response to antigenic stimulus	GO:0002439	3	0.061	Mouse
striated muscle cell development	GO:0055002	125	0.061
b cell activation	GO:0042113	161	0.061
dephosphorylation	GO:0016311	129	0.061
positive regulation of transferase activity	GO:0051347	167	0.061
positive regulation of ion transport	GO:0043270	65	0.061
somatic recombination of immunoglobulin gene segments	GO:0016447	42	0.060
negative regulation of protein processing	GO:0010955	79	0.060	Mouse
organic hydroxy compound metabolic process	GO:1901615	203	0.060
negative regulation of growth of symbiont involved in interaction with host	GO:0044146	19	0.060	Mouse
response to dsrna	GO:0043331	30	0.060
amine metabolic process	GO:0009308	45	0.059
antigen receptor mediated signaling pathway	GO:0050851	64	0.059
stem cell development	GO:0048864	219	0.059
negative regulation of phosphorus metabolic process	GO:0010563	184	0.059
glucose transport	GO:0015758	56	0.059
monosaccharide metabolic process	GO:0005996	106	0.058
carbohydrate transport	GO:0008643	62	0.058
digestive tract development	GO:0048565	190	0.058
negative regulation of phosphorylation	GO:0042326	166	0.058
positive regulation of kinase activity	GO:0033674	155	0.058
spermatogenesis	GO:0007283	284	0.058
positive regulation of cell migration	GO:0030335	109	0.058
regulation of myeloid cell differentiation	GO:0045637	96	0.057
cellular response to hormone stimulus	GO:0032870	150	0.057
acute inflammatory response	GO:0002526	41	0.057
regulation of protein localization	GO:0032880	231	0.057
lipid transport	GO:0006869	98	0.057
regulation of cellular catabolic process	GO:0031329	242	0.056
male gamete generation	GO:0048232	285	0.056
response to peptide	GO:1901652	136	0.056
antimicrobial peptide production	GO:0002775	2	0.055
regulation of cytokine production involved in immune response	GO:0002718	26	0.055
protein import into nucleus	GO:0006606	95	0.055
mammary gland epithelial cell proliferation	GO:0033598	24	0.055
organonitrogen compound biosynthetic process	GO:1901566	192	0.054
cellular amide metabolic process	GO:0043603	58	0.054
regulation of glucose transport	GO:0010827	32	0.054
defense response to gram positive bacterium	GO:0050830	50	0.054
neuron death	GO:0070997	154	0.054
cellular ion homeostasis	GO:0006873	165	0.054
negative regulation of extrinsic apoptotic signaling pathway	GO:2001237	45	0.054	Mouse
response to organic cyclic compound	GO:0014070	198	0.054
protein localization to organelle	GO:0033365	185	0.054
positive regulation of leukocyte mediated immunity	GO:0002705	70	0.054
negative regulation of defense response	GO:0031348	77	0.054
regulation of production of molecular mediator of immune response	GO:0002700	65	0.054
cellular response to molecule of bacterial origin	GO:0071219	83	0.054	Mouse
extrinsic apoptotic signaling pathway	GO:0097191	126	0.054	Mouse
anatomical structure homeostasis	GO:0060249	145	0.054
defense response to virus	GO:0051607	68	0.054
positive regulation of adaptive immune response based on somatic recombination of immune receptors built from immunoglobulin superfamily domains	GO:0002824	61	0.053
axonogenesis	GO:0007409	274	0.053
negative regulation of cellular amine metabolic process	GO:0033239	1	0.053
lymphocyte mediated immunity	GO:0002449	139	0.053
positive regulation of cell motility	GO:2000147	116	0.053
response to nutrient levels	GO:0031667	109	0.052
interleukin 5 secretion	GO:0072603	2	0.052
stress activated protein kinase signaling cascade	GO:0031098	81	0.052
cellular response to extracellular stimulus	GO:0031668	81	0.052
response to radiation	GO:0009314	165	0.052
skin development	GO:0043588	220	0.052
positive regulation of adaptive immune response	GO:0002821	61	0.052
respiratory system development	GO:0060541	190	0.051
regulation of interleukin 5 secretion	GO:2000662	2	0.051
negative regulation of cytokine production	GO:0001818	84	0.051	Mouse
symbiosis encompassing mutualism through parasitism	GO:0044403	83	0.051	Mouse
peptidyl amino acid modification	GO:0018193	336	0.051
regulation of leukocyte differentiation	GO:1902105	159	0.051
leukocyte migration	GO:0050900	124	0.051
cellular response to oxidative stress	GO:0034599	76	0.051
appendage development	GO:0048736	166	0.050
embryonic placenta development	GO:0001892	98	0.050	Mouse
lymphocyte differentiation	GO:0030098	242	0.050
muscle fiber development	GO:0048747	76	0.050
response to organonitrogen compound	GO:0010243	246	0.050
posttranscriptional regulation of gene expression	GO:0010608	155	0.049
regulation of interleukin 13 secretion	GO:2000665	2	0.049
cell fate commitment	GO:0045165	210	0.049
cellular response to biotic stimulus	GO:0071216	92	0.049	Mouse
positive regulation of osteoclast differentiation	GO:0045672	15	0.049
cellular macromolecule catabolic process	GO:0044265	206	0.049
lipid biosynthetic process	GO:0008610	179	0.049
negative regulation of secretion	GO:0051048	61	0.049
immune response regulating signaling pathway	GO:0002764	125	0.048
regulation of protein targeting	GO:1903533	61	0.048
nucleocytoplasmic transport	GO:0006913	139	0.048
macromolecule catabolic process	GO:0009057	281	0.048
regulation of peptide transport	GO:0090087	91	0.047
myotube differentiation	GO:0014902	105	0.047
regulation of intracellular transport	GO:0032386	159	0.047
regulation of peptidyl tyrosine phosphorylation	GO:0050730	93	0.047
carbohydrate homeostasis	GO:0033500	128	0.046
ear development	GO:0043583	200	0.046
myelination	GO:0042552	74	0.046
regulation of cellular ketone metabolic process	GO:0010565	66	0.046
response to growth factor	GO:0070848	198	0.046
regulation of osteoclast differentiation	GO:0045670	36	0.046
proteolysis involved in cellular protein catabolic process	GO:0051603	147	0.046
regulation of metal ion transport	GO:0010959	106	0.045
negative regulation of protein metabolic process	GO:0051248	282	0.045	Mouse
regulation of lymphocyte proliferation	GO:0050670	117	0.045
positive regulation of lymphocyte proliferation	GO:0050671	70	0.045
cellular response to organonitrogen compound	GO:0071417	145	0.045
single organism cell adhesion	GO:0098602	156	0.045
regulation of neuron differentiation	GO:0045664	281	0.045
positive regulation of secretion by cell	GO:1903532	114	0.045
innate immune response	GO:0045087	157	0.045
calcium ion transport	GO:0006816	159	0.045
response to inorganic substance	GO:0010035	96	0.045
divalent metal ion transport	GO:0070838	172	0.044
sequestering of calcium ion	GO:0051208	18	0.044
molting cycle	GO:0042303	90	0.044
regulation of protein secretion	GO:0050708	82	0.044
leukocyte apoptotic process	GO:0071887	71	0.044
heart morphogenesis	GO:0003007	178	0.044
negative regulation of intracellular signal transduction	GO:1902532	167	0.043
somatic diversification of immunoglobulins involved in immune response	GO:0002208	36	0.043
glial cell differentiation	GO:0010001	131	0.043
regulation of map kinase activity	GO:0043405	120	0.043
membrane organization	GO:0061024	245	0.043
regulation of lipid transport	GO:0032368	36	0.043
regulation of cysteine type endopeptidase activity involved in apoptotic process	GO:0043281	62	0.043	Mouse
liver development	GO:0001889	66	0.043
regulation of immunoglobulin mediated immune response	GO:0002889	37	0.042
muscle tissue development	GO:0060537	308	0.042
regulation of stress activated mapk cascade	GO:0032872	69	0.042
calcium ion homeostasis	GO:0055074	127	0.042
muscle cell development	GO:0055001	133	0.042
regulation of translational initiation by iron	GO:0006447	2	0.042
regulation of intrinsic apoptotic signaling pathway	GO:2001242	61	0.042	Mouse
stress activated mapk cascade	GO:0051403	80	0.041
sensory organ morphogenesis	GO:0090596	242	0.041
positive regulation of t cell proliferation	GO:0042102	52	0.041
regulation of reactive oxygen species metabolic process	GO:2000377	40	0.041
positive regulation of sequence specific dna binding transcription factor activity	GO:0051091	68	0.041
antimicrobial peptide biosynthetic process	GO:0002777	2	0.041
gliogenesis	GO:0042063	141	0.041
interspecies interaction between organisms	GO:0044419	83	0.041	Mouse
somatic recombination of immunoglobulin genes involved in immune response	GO:0002204	36	0.041
negative regulation of cellular amino acid metabolic process	GO:0045763	0	0.041
hormone metabolic process	GO:0042445	86	0.041
regulation of defense response to bacterium	GO:1900424	3	0.041
skeletal muscle organ development	GO:0060538	163	0.040
positive regulation of myeloid cell differentiation	GO:0045639	43	0.040
regulation of tumor necrosis factor production	GO:0032680	49	0.040	Mouse
monosaccharide transport	GO:0015749	58	0.040
peptide metabolic process	GO:0006518	46	0.040
regulation of dna recombination	GO:0000018	34	0.040
sequestering of metal ion	GO:0051238	19	0.040
lymphocyte homeostasis	GO:0002260	64	0.040
protein catabolic process	GO:0030163	221	0.039
temperature homeostasis	GO:0001659	26	0.039
cell maturation	GO:0048469	127	0.039
regulation of anatomical structure size	GO:0090066	178	0.039
activation of innate immune response	GO:0002218	56	0.039
regulation of jnk cascade	GO:0046328	62	0.039
positive regulation of cytoplasmic transport	GO:1903651	40	0.039
generation of precursor metabolites and energy	GO:0006091	103	0.039
positive regulation of cysteine type endopeptidase activity	GO:2001056	39	0.039	Mouse
extracellular matrix organization	GO:0030198	147	0.039
oligodendrocyte differentiation	GO:0048709	53	0.038
morphogenesis of a branching epithelium	GO:0061138	193	0.038	Mouse
response to peptide hormone	GO:0043434	127	0.038
regulation of peptide secretion	GO:0002791	77	0.038
regulation of cytokine biosynthetic process	GO:0042035	59	0.038
regulation of humoral immune response mediated by circulating immunoglobulin	GO:0002923	10	0.038
intracellular receptor signaling pathway	GO:0030522	74	0.038
positive regulation of protein secretion	GO:0050714	52	0.038
angiogenesis	GO:0001525	201	0.038
negative regulation of proteolysis	GO:0045861	74	0.038	Mouse
cytosolic calcium ion homeostasis	GO:0051480	70	0.037
positive regulation of antibacterial peptide biosynthetic process	GO:0006963	1	0.037
negative regulation of t cell activation	GO:0050868	65	0.037
regulation of peptide hormone secretion	GO:0090276	75	0.037
digestive tract morphogenesis	GO:0048546	147	0.037
negative regulation of lymphocyte activation	GO:0051250	91	0.037
hexose transport	GO:0008645	56	0.036
interleukin 1 production	GO:0032612	31	0.036
regulation of lipid metabolic process	GO:0019216	118	0.036
granulocyte chemotaxis	GO:0071621	39	0.036
negative regulation of cell cycle	GO:0045786	123	0.036
multicellular organism growth	GO:0035264	161	0.036
protein targeting	GO:0006605	143	0.036
peptide hormone secretion	GO:0030072	109	0.036
myeloid dendritic cell activation	GO:0001773	25	0.036	Mouse
heat generation	GO:0031649	13	0.036
interleukin 18 production	GO:0032621	4	0.036
positive regulation of jnk cascade	GO:0046330	46	0.036
regulation of organ morphogenesis	GO:2000027	144	0.035
establishment of protein localization to organelle	GO:0072594	118	0.035
positive regulation of cellular amine metabolic process	GO:0033240	5	0.035
positive regulation of stress activated mapk cascade	GO:0032874	48	0.035
negative regulation of peptidase activity	GO:0010466	46	0.035	Mouse
immune response activating cell surface receptor signaling pathway	GO:0002429	72	0.035
hair follicle development	GO:0001942	85	0.035
regulation of epithelial cell proliferation	GO:0050678	141	0.035
regulation of antigen receptor mediated signaling pathway	GO:0050854	29	0.034
positive regulation of leukocyte differentiation	GO:1902107	86	0.034
positive regulation of erk1 and erk2 cascade	GO:0070374	47	0.034
ameboidal type cell migration	GO:0001667	128	0.034
mitotic cell cycle process	GO:1903047	159	0.034
positive regulation of protein transport	GO:0051222	93	0.034
b cell mediated immunity	GO:0019724	71	0.034
monocarboxylic acid metabolic process	GO:0032787	191	0.034
positive regulation of antimicrobial peptide production	GO:0002225	1	0.034
heterocycle catabolic process	GO:0046700	280	0.034
ossification	GO:0001503	216	0.033
mitochondrion organization	GO:0007005	134	0.033
hexose metabolic process	GO:0019318	98	0.033
peptide secretion	GO:0002790	114	0.033
positive regulation of immune effector process	GO:0002699	107	0.033
ion transmembrane transport	GO:0034220	361	0.033
lung development	GO:0030324	164	0.033
cellular metal ion homeostasis	GO:0006875	151	0.033
neural tube development	GO:0021915	160	0.033
positive regulation of intracellular protein transport	GO:0090316	42	0.033
negative regulation of macrophage apoptotic process	GO:2000110	3	0.033
positive regulation of intracellular transport	GO:0032388	70	0.033
positive regulation of cytosolic calcium ion concentration	GO:0007204	65	0.033
negative regulation of ossification	GO:0030279	49	0.033
regulation of ion transmembrane transport	GO:0034765	119	0.033
jnk cascade	GO:0007254	72	0.033
wound healing	GO:0042060	157	0.033
immunoglobulin production involved in immunoglobulin mediated immune response	GO:0002381	43	0.033
stem cell maintenance	GO:0019827	130	0.033
glucose import	GO:0046323	32	0.033
multi multicellular organism process	GO:0044706	109	0.032
positive regulation of mitotic cell cycle	GO:0045931	41	0.032
muscle contraction	GO:0006936	101	0.032
regulation of wnt signaling pathway	GO:0030111	123	0.032
regulation of action potential	GO:0098900	4	0.032
glycerolipid metabolic process	GO:0046486	122	0.031
response to light stimulus	GO:0009416	135	0.031
positive regulation of protein kinase b signaling	GO:0051897	32	0.031
regulation of protein kinase b signaling	GO:0051896	56	0.031
forebrain development	GO:0030900	302	0.031
regulation of lymphocyte differentiation	GO:0045619	107	0.031
positive regulation of interleukin 2 production	GO:0032743	19	0.031
respiratory tube development	GO:0030323	167	0.031
single organismal cell cell adhesion	GO:0016337	131	0.031
modification dependent protein catabolic process	GO:0019941	133	0.030
positive regulation of homeostatic process	GO:0032846	64	0.030
regulation of cytoplasmic transport	GO:1903649	112	0.030
myeloid leukocyte activation	GO:0002274	83	0.030	Mouse
tissue remodeling	GO:0048771	102	0.030
single organism nuclear import	GO:1902593	95	0.030
immune response regulating cell surface receptor signaling pathway	GO:0002768	80	0.030
protein complex localization	GO:0031503	19	0.030
positive regulation of response to wounding	GO:1903036	66	0.030
regulation of cell cycle process	GO:0010564	160	0.030
mitotic cell cycle	GO:0000278	195	0.030
maintenance of location	GO:0051235	89	0.030
regulation of antibacterial peptide production	GO:0002786	1	0.029
leukocyte homeostasis	GO:0001776	79	0.029
positive regulation of interleukin 6 production	GO:0032755	37	0.029
response to extracellular stimulus	GO:0009991	127	0.029
protein localization to nucleus	GO:0034504	121	0.029
cell activation involved in immune response	GO:0002263	126	0.029
response to oxygen levels	GO:0070482	62	0.029
osteoclast differentiation	GO:0030316	62	0.029
cerebral cortex development	GO:0021987	86	0.029
insulin secretion	GO:0030073	89	0.029
regulation of glucose import	GO:0046324	26	0.029
cell chemotaxis	GO:0060326	81	0.029
reactive nitrogen species metabolic process	GO:2001057	0	0.029
fat soluble vitamin biosynthetic process	GO:0042362	4	0.028
ras protein signal transduction	GO:0007265	77	0.028
negative regulation of protein maturation	GO:1903318	79	0.028	Mouse

Il22 disease predictions

Disease predictions are made from cross-annotation of human disease genes to the identified functional analogs in mouse and predicted with the mouse functional network.

Disease	DO term ID	Probability
cancer	DOID:162	0.150
organ system cancer	DOID:0050686	0.150
disease of cellular proliferation	DOID:14566	0.150
nervous system disease	DOID:863	0.059
disease of anatomical entity	DOID:7	0.059
central nervous system disease	DOID:331	0.030

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