IMP: Integrative Multi-species Prediction

Mus musculus

56 known processes

Gna11

guanine nucleotide binding protein, alpha 11

(Aliases: Dsk7,E430025L19)

Entrez: 14672
Ensembl: ENSMUSG00000034781
UniProtKB: Q3UPA1
UniProtKB: P21278

Process Predictions
Disease Predictions

Gna11 biological process predictions

Show only novel predictionsHighlight processes of functional analogs

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Biological process	GO term ID	Process size	Probability	Func Analog Org
regulation of cellular amine metabolic process	GO:0033238	20	0.668
cholesterol homeostasis	GO:0042632	44	0.635
regionalization	GO:0003002	337	0.561
circulatory system process	GO:0003013	197	0.477	Mouse
regulation of defense response	GO:0031347	233	0.453
amine metabolic process	GO:0009308	45	0.449
proteolysis involved in cellular protein catabolic process	GO:0051603	147	0.424	Mouse
cellular amino acid metabolic process	GO:0006520	103	0.342
ras protein signal transduction	GO:0007265	77	0.326	Mouse
cellular ketone metabolic process	GO:0042180	84	0.308
carbohydrate derivative biosynthetic process	GO:1901137	183	0.291	Mouse
positive regulation of apoptotic signaling pathway	GO:2001235	95	0.276
positive regulation of cellular amino acid metabolic process	GO:0045764	3	0.271
regulation of hydrolase activity	GO:0051336	246	0.255	Fly
leukocyte differentiation	GO:0002521	342	0.255	Mouse
cellular amine metabolic process	GO:0044106	44	0.245
telencephalon development	GO:0021537	186	0.242
striated muscle tissue development	GO:0014706	293	0.238
cellular response to radiation	GO:0071478	28	0.237	Fly
multicellular organism growth	GO:0035264	161	0.237	Mouse
negative regulation of epithelial cell proliferation	GO:0050680	64	0.233
positive regulation of cellular amine metabolic process	GO:0033240	5	0.229
modification dependent protein catabolic process	GO:0019941	133	0.229	Mouse
negative regulation of protein metabolic process	GO:0051248	282	0.227
positive regulation of apoptotic process	GO:0043065	217	0.210
epithelial tube morphogenesis	GO:0060562	303	0.207	Mouse
regulation of mapk cascade	GO:0043408	248	0.202
lipid homeostasis	GO:0055088	63	0.201
apoptotic signaling pathway	GO:0097190	306	0.199
appendage development	GO:0048736	166	0.197	Mouse
positive regulation of programmed cell death	GO:0043068	218	0.194
wnt signaling pathway	GO:0016055	188	0.190
regulation of cellular ketone metabolic process	GO:0010565	66	0.189
mapk cascade	GO:0000165	281	0.187
regulation of protein kinase activity	GO:0045859	232	0.187
regulation of heart contraction	GO:0008016	77	0.185	Mouse
regulation of lipid metabolic process	GO:0019216	118	0.184
ubiquitin dependent protein catabolic process	GO:0006511	129	0.183	Mouse
forebrain development	GO:0030900	302	0.178	Mouse
urogenital system development	GO:0001655	261	0.177
protein localization to nucleus	GO:0034504	121	0.173
regulation of cellular amino acid metabolic process	GO:0006521	5	0.172
regulation of intracellular transport	GO:0032386	159	0.168
response to radiation	GO:0009314	165	0.161	Mouse Fly
cytoplasmic transport	GO:0016482	234	0.161
negative regulation of molecular function	GO:0044092	258	0.160
action potential	GO:0001508	78	0.160
regulation of homeostatic process	GO:0032844	182	0.158
bone development	GO:0060348	120	0.156	Mouse
negative regulation of phosphorus metabolic process	GO:0010563	184	0.155
activation of adenylate cyclase activity	GO:0007190	4	0.154	Mouse
negative regulation of intracellular signal transduction	GO:1902532	167	0.149
epithelial cell proliferation	GO:0050673	174	0.145
monocarboxylic acid metabolic process	GO:0032787	191	0.141
positive regulation of cell death	GO:0010942	224	0.140
inflammatory response	GO:0006954	244	0.140
skeletal system development	GO:0001501	356	0.138
sensory perception	GO:0007600	245	0.137	Mouse Fly
dna metabolic process	GO:0006259	303	0.137	Mouse
cellular lipid metabolic process	GO:0044255	323	0.134
endomembrane system organization	GO:0010256	147	0.134
negative regulation of cellular component organization	GO:0051129	194	0.131
small gtpase mediated signal transduction	GO:0007264	97	0.130	Mouse
purine containing compound biosynthetic process	GO:0072522	70	0.127	Mouse
muscle cell differentiation	GO:0042692	261	0.126
negative regulation of cellular amino acid metabolic process	GO:0045763	0	0.125
regulation of proteolysis	GO:0030162	164	0.125	Mouse
negative regulation of cellular protein metabolic process	GO:0032269	247	0.125
spermatogenesis	GO:0007283	284	0.124
regulation of protein transport	GO:0051223	163	0.123
protein localization to organelle	GO:0033365	185	0.121
regulation of epithelial cell proliferation	GO:0050678	141	0.115
negative regulation of cellular amine metabolic process	GO:0033239	1	0.115
homeostasis of number of cells	GO:0048872	210	0.115
sterol homeostasis	GO:0055092	45	0.114
response to light stimulus	GO:0009416	135	0.113	Mouse Fly
regulation of kinase activity	GO:0043549	249	0.112
development of primary sexual characteristics	GO:0045137	143	0.111
regulation of protein localization	GO:0032880	231	0.109
response to temperature stimulus	GO:0009266	55	0.108	Fly
regulation of secretion	GO:0051046	274	0.108	Worm
organonitrogen compound biosynthetic process	GO:1901566	192	0.107	Mouse
maintenance of location	GO:0051235	89	0.107
sensory perception of umami taste	GO:0050917	4	0.107	Mouse
gland development	GO:0048732	330	0.106
fatty acid metabolic process	GO:0006631	121	0.105
nuclear division	GO:0000280	158	0.104
stress activated protein kinase signaling cascade	GO:0031098	81	0.104
regulation of protein import into nucleus	GO:0042306	52	0.102
regulation of secretion by cell	GO:1903530	249	0.101	Worm
bmp signaling pathway	GO:0030509	93	0.101
camera type eye development	GO:0043010	266	0.100	Mouse
negative regulation of kinase activity	GO:0033673	81	0.100
extrinsic apoptotic signaling pathway	GO:0097191	126	0.099
endocytosis	GO:0006897	168	0.099	Fly
rhodopsin mediated signaling pathway	GO:0016056	4	0.098	Fly
regulation of tor signaling	GO:0032006	17	0.098	Mouse
neural tube development	GO:0021915	160	0.097
negative regulation of mapk cascade	GO:0043409	65	0.097
regulation of fatty acid metabolic process	GO:0019217	28	0.096
morphogenesis of a branching structure	GO:0001763	203	0.096	Mouse
negative regulation of cell proliferation	GO:0008285	296	0.096
regulation of apoptotic signaling pathway	GO:2001233	197	0.095
stress activated mapk cascade	GO:0051403	80	0.095
glycoprotein biosynthetic process	GO:0009101	89	0.095
negative regulation of phosphate metabolic process	GO:0045936	184	0.094
regulation of peptide transport	GO:0090087	91	0.094
cellular macromolecule catabolic process	GO:0044265	206	0.094	Mouse
acetylcholine transport	GO:0015870	2	0.093	Worm
embryonic appendage morphogenesis	GO:0035113	126	0.091	Mouse
g protein coupled acetylcholine receptor signaling pathway	GO:0007213	4	0.091	Mouse
g protein coupled receptor signaling pathway	GO:0007186	243	0.090
synaptic transmission	GO:0007268	329	0.090	Worm
negative regulation of transferase activity	GO:0051348	85	0.090
ribonucleotide biosynthetic process	GO:0009260	59	0.089	Mouse
g protein coupled receptor signaling pathway coupled to cyclic nucleotide second messenger	GO:0007187	55	0.086	Mouse
negative regulation of phosphorylation	GO:0042326	166	0.085
rho protein signal transduction	GO:0007266	32	0.085	Mouse
intrinsic apoptotic signaling pathway	GO:0097193	132	0.084
axonogenesis	GO:0007409	274	0.084	Fly
lipid catabolic process	GO:0016042	69	0.084
lipid localization	GO:0010876	126	0.083
sensory organ morphogenesis	GO:0090596	242	0.083	Mouse Fly
branching morphogenesis of an epithelial tube	GO:0048754	159	0.083	Mouse
proteasomal protein catabolic process	GO:0010498	98	0.083	Mouse
skeletal muscle organ development	GO:0060538	163	0.083
cerebral cortex development	GO:0021987	86	0.082
nucleotide biosynthetic process	GO:0009165	78	0.082	Mouse
morphogenesis of embryonic epithelium	GO:0016331	159	0.082
regulation of membrane potential	GO:0042391	192	0.081
negative regulation of transforming growth factor beta receptor signaling pathway	GO:0030512	26	0.081
photoreceptor cell differentiation	GO:0046530	52	0.081	Mouse
glycerolipid metabolic process	GO:0046486	122	0.080
germ cell development	GO:0007281	185	0.080
regulation of map kinase activity	GO:0043405	120	0.080
organic cyclic compound catabolic process	GO:1901361	295	0.080	Mouse Fly
cellular homeostasis	GO:0019725	240	0.079	Mouse
regulation of peptide hormone secretion	GO:0090276	75	0.079
organelle localization	GO:0051640	179	0.079
regulation of nucleocytoplasmic transport	GO:0046822	73	0.078
cellular divalent inorganic cation homeostasis	GO:0072503	127	0.078	Mouse
transmembrane receptor protein serine threonine kinase signaling pathway	GO:0007178	194	0.078
generation of precursor metabolites and energy	GO:0006091	103	0.078	Mouse
cellular chemical homeostasis	GO:0055082	215	0.077	Mouse
regulation of cell shape	GO:0008360	39	0.077	Mouse
negative regulation of map kinase activity	GO:0043407	34	0.076
positive regulation of protein kinase activity	GO:0045860	144	0.076
blood circulation	GO:0008015	195	0.076	Mouse
regulation of neuron differentiation	GO:0045664	281	0.076
carbohydrate homeostasis	GO:0033500	128	0.076
pallium development	GO:0021543	120	0.075
regulation of organ morphogenesis	GO:2000027	144	0.075	Fly
regulation of chromatin modification	GO:1903308	57	0.074
glycoprotein metabolic process	GO:0009100	116	0.074
male gamete generation	GO:0048232	285	0.074
nucleobase containing small molecule metabolic process	GO:0055086	352	0.073	Mouse Fly
mammary gland epithelium development	GO:0061180	65	0.073
cell type specific apoptotic process	GO:0097285	268	0.073
nucleocytoplasmic transport	GO:0006913	139	0.073
regulation of protein serine threonine kinase activity	GO:0071900	157	0.072
protein targeting	GO:0006605	143	0.072
innate immune response	GO:0045087	157	0.072
regulation of erk1 and erk2 cascade	GO:0070372	71	0.072
nuclear transport	GO:0051169	139	0.072
kidney development	GO:0001822	213	0.071
neural tube formation	GO:0001841	108	0.071
detection of abiotic stimulus	GO:0009582	60	0.071	Mouse Fly
neutral lipid metabolic process	GO:0006638	57	0.071
protein import	GO:0017038	101	0.070
transmission of nerve impulse	GO:0019226	76	0.070
morphogenesis of a branching epithelium	GO:0061138	193	0.069	Mouse
response to lipopolysaccharide	GO:0032496	128	0.069
carbohydrate metabolic process	GO:0005975	230	0.069
appendage morphogenesis	GO:0035107	149	0.069	Mouse
columnar cuboidal epithelial cell differentiation	GO:0002065	82	0.068
limb development	GO:0060173	166	0.068	Mouse
ensheathment of neurons	GO:0007272	76	0.068
muscle tissue development	GO:0060537	308	0.068
response to organonitrogen compound	GO:0010243	246	0.068	Mouse
regulation of hormone levels	GO:0010817	211	0.068
regulation of cell morphogenesis involved in differentiation	GO:0010769	151	0.067
adenylate cyclase modulating g protein coupled receptor signaling pathway	GO:0007188	54	0.067	Mouse
protein import into nucleus	GO:0006606	95	0.067
regulation of canonical wnt signaling pathway	GO:0060828	82	0.067
regulation of cytoplasmic transport	GO:1903649	112	0.066
regulation of nucleotide metabolic process	GO:0006140	169	0.066	Mouse
lipid biosynthetic process	GO:0008610	179	0.066
regulation of transferase activity	GO:0051338	263	0.066
purine ribonucleotide metabolic process	GO:0009150	290	0.066	Mouse Fly
cation homeostasis	GO:0055080	212	0.066	Mouse
embryonic epithelial tube formation	GO:0001838	130	0.066
positive regulation of cellular catabolic process	GO:0031331	148	0.066
jnk cascade	GO:0007254	72	0.066
neural tube closure	GO:0001843	90	0.065
regulation of intracellular protein transport	GO:0033157	82	0.065
myeloid leukocyte differentiation	GO:0002573	119	0.064	Mouse
cellular response to acid chemical	GO:0071229	68	0.064
regulation of protein targeting	GO:1903533	61	0.064
regulation of binding	GO:0051098	111	0.064
regulation of cell motility	GO:2000145	236	0.064	Mouse
regulation of hormone secretion	GO:0046883	88	0.064
amide transport	GO:0042886	138	0.064
translation	GO:0006412	93	0.063
mitochondrion organization	GO:0007005	134	0.063
negative regulation of protein modification process	GO:0031400	163	0.062
response to inorganic substance	GO:0010035	96	0.062	Fly
negative regulation of tyrosine phosphorylation of stat5 protein	GO:0042524	2	0.061
hindlimb morphogenesis	GO:0035137	42	0.060	Mouse
nucleoside phosphate biosynthetic process	GO:1901293	79	0.060	Mouse
regulation of leukocyte differentiation	GO:1902105	159	0.060	Mouse
placenta development	GO:0001890	140	0.060
regulation of blood circulation	GO:1903522	93	0.059	Mouse
regulation of extrinsic apoptotic signaling pathway	GO:2001236	77	0.059
organic acid transport	GO:0015849	101	0.059
intracellular protein transport	GO:0006886	204	0.058
negative regulation of protein serine threonine kinase activity	GO:0071901	49	0.058
tube formation	GO:0035148	140	0.058
detection of stimulus	GO:0051606	84	0.058	Mouse Fly
endochondral bone morphogenesis	GO:0060350	50	0.058	Mouse
regulation of inflammatory response	GO:0050727	147	0.057
multicellular organismal homeostasis	GO:0048871	164	0.057	Mouse
glycosyl compound catabolic process	GO:1901658	206	0.057	Mouse Fly
organelle fission	GO:0048285	170	0.057
dendrite development	GO:0016358	115	0.057
calcium ion homeostasis	GO:0055074	127	0.056	Mouse
response to monosaccharide	GO:0034284	67	0.056
membrane organization	GO:0061024	245	0.056
positive regulation of extrinsic apoptotic signaling pathway	GO:2001238	34	0.056
regulation of establishment of protein localization	GO:0070201	181	0.056
regulation of circadian rhythm	GO:0042752	58	0.055
cellular response to cytokine stimulus	GO:0071345	189	0.055
meiotic nuclear division	GO:0007126	115	0.055
protein oligomerization	GO:0051259	67	0.055
localization within membrane	GO:0051668	4	0.055
response to molecule of bacterial origin	GO:0002237	143	0.055
skeletal system morphogenesis	GO:0048705	203	0.054	Mouse
negative regulation of cellular response to growth factor stimulus	GO:0090288	46	0.054
cation transport	GO:0006812	399	0.054	Worm
negative regulation of protein phosphorylation	GO:0001933	126	0.054
negative regulation of peptidyl tyrosine phosphorylation	GO:0050732	17	0.054
anatomical structure homeostasis	GO:0060249	145	0.054	Mouse
peptidyl serine modification	GO:0018209	83	0.054
fertilization	GO:0009566	127	0.053
cellular ion homeostasis	GO:0006873	165	0.053	Mouse
heart morphogenesis	GO:0003007	178	0.053
connective tissue development	GO:0061448	179	0.053	Mouse
cellular response to light stimulus	GO:0071482	19	0.052	Fly
regulation of protein binding	GO:0043393	60	0.052
regulation of myeloid leukocyte differentiation	GO:0002761	58	0.052	Mouse
ribose phosphate biosynthetic process	GO:0046390	59	0.051	Mouse
regulation of cellular catabolic process	GO:0031329	242	0.051	Mouse
sulfur compound metabolic process	GO:0006790	100	0.051
mitotic cell cycle	GO:0000278	195	0.051
protein modification by small protein conjugation or removal	GO:0070647	207	0.051
regulation of chromosome organization	GO:0033044	83	0.051
insulin secretion	GO:0030073	89	0.051
regulation of synaptic growth at neuromuscular junction	GO:0008582	4	0.051
regulation of cell projection organization	GO:0031344	206	0.050
protein catabolic process	GO:0030163	221	0.050	Mouse Worm
peptide secretion	GO:0002790	114	0.050
regulation of feeding behavior	GO:0060259	3	0.050	Worm
gonad development	GO:0008406	141	0.050
reactive nitrogen species metabolic process	GO:2001057	0	0.049
regulation of body fluid levels	GO:0050878	162	0.049	Mouse
embryonic organ morphogenesis	GO:0048562	276	0.049	Mouse
b cell differentiation	GO:0030183	78	0.049
proteoglycan biosynthetic process	GO:0030166	20	0.049
retina morphogenesis in camera type eye	GO:0060042	45	0.048	Mouse
regulation of peptidyl tyrosine phosphorylation	GO:0050730	93	0.048
regulation of acetylcholine secretion neurotransmission	GO:0014056	2	0.048	Worm
regulation of cell cycle process	GO:0010564	160	0.048
energy derivation by oxidation of organic compounds	GO:0015980	77	0.048	Mouse
single organism nuclear import	GO:1902593	95	0.048
epithelial cell development	GO:0002064	159	0.048
compound eye development	GO:0048749	1	0.048	Fly
rhythmic process	GO:0048511	174	0.047
carboxylic acid transport	GO:0046942	100	0.047
epithelial tube formation	GO:0072175	130	0.047
immune response regulating signaling pathway	GO:0002764	125	0.047
cyclic purine nucleotide metabolic process	GO:0052652	43	0.047	Mouse
regulation of peptide secretion	GO:0002791	77	0.047
embryonic skeletal system morphogenesis	GO:0048704	91	0.047	Mouse
central nervous system neuron differentiation	GO:0021953	162	0.047	Mouse
heart process	GO:0003015	94	0.047	Mouse
myeloid cell differentiation	GO:0030099	233	0.047	Mouse
regulation of protein localization to nucleus	GO:1900180	60	0.046
cardiac chamber development	GO:0003205	108	0.046
organ growth	GO:0035265	117	0.046
embryonic limb morphogenesis	GO:0030326	126	0.046	Mouse
nucleoside phosphate metabolic process	GO:0006753	338	0.046	Mouse Fly
positive regulation of defense response	GO:0031349	124	0.045
lung development	GO:0030324	164	0.045
positive regulation of kinase activity	GO:0033674	155	0.045
peptide hormone secretion	GO:0030072	109	0.045
negative regulation of cell cycle	GO:0045786	123	0.045
regulation of phospholipase c activity	GO:1900274	3	0.044	Fly
regulation of reactive oxygen species metabolic process	GO:2000377	40	0.044
negative regulation of growth	GO:0045926	99	0.044	Mouse
cyclic nucleotide biosynthetic process	GO:0009190	44	0.044	Mouse
pigmentation	GO:0043473	71	0.044
cardiac muscle tissue development	GO:0048738	130	0.043
respiratory system development	GO:0060541	190	0.043
chemotaxis	GO:0006935	247	0.043	Fly
macromolecule methylation	GO:0043414	120	0.043	Mouse
regulation of jnk cascade	GO:0046328	62	0.043
cell maturation	GO:0048469	127	0.043	Mouse
regulation of cell migration	GO:0030334	219	0.043	Mouse
detection of external stimulus	GO:0009581	61	0.043	Mouse Fly
protein homooligomerization	GO:0051260	43	0.043
regulation of response to wounding	GO:1903034	189	0.043
purine nucleotide metabolic process	GO:0006163	302	0.042	Mouse Fly
positive regulation of nucleotide biosynthetic process	GO:0030810	26	0.042	Mouse
canonical wnt signaling pathway	GO:0060070	130	0.042
bone morphogenesis	GO:0060349	78	0.041	Mouse
purine ribonucleotide biosynthetic process	GO:0009152	59	0.041	Mouse
cellular metal ion homeostasis	GO:0006875	151	0.041	Mouse
organophosphate catabolic process	GO:0046434	232	0.041	Mouse Fly
cellular response to abiotic stimulus	GO:0071214	56	0.041
glycosyl compound metabolic process	GO:1901657	246	0.041	Mouse Fly
establishment of protein localization to organelle	GO:0072594	118	0.041
regulation of cellular response to stress	GO:0080135	159	0.041
adult locomotory behavior	GO:0008344	91	0.041	Fly
regulation of innate immune response	GO:0045088	91	0.040
regulation of receptor activity	GO:0010469	41	0.040
positive regulation of fatty acid oxidation	GO:0046321	4	0.040
regulation of bmp signaling pathway	GO:0030510	60	0.040
cytokine mediated signaling pathway	GO:0019221	115	0.040
phospholipid metabolic process	GO:0006644	87	0.040
nitrogen compound transport	GO:0071705	271	0.040	Worm
cellular protein catabolic process	GO:0044257	155	0.039	Mouse
response to drug	GO:0042493	75	0.039	Mouse
positive regulation of cell motility	GO:2000147	116	0.039
cell cycle arrest	GO:0007050	37	0.039
hormone secretion	GO:0046879	128	0.039
regulation of multi organism process	GO:0043900	111	0.039	Worm
response to retinoic acid	GO:0032526	56	0.039
cardiac muscle cell differentiation	GO:0055007	69	0.038
regulation of t cell activation	GO:0050863	170	0.038
camera type eye photoreceptor cell differentiation	GO:0060219	15	0.038	Mouse
developmental maturation	GO:0021700	193	0.038	Mouse
glucose homeostasis	GO:0042593	128	0.038
heart contraction	GO:0060047	93	0.038	Mouse
regulation of vesicle mediated transport	GO:0060627	139	0.038
reactive oxygen species metabolic process	GO:0072593	84	0.038
regulation of wnt signaling pathway	GO:0030111	123	0.038
cardiac chamber morphogenesis	GO:0003206	93	0.038
modification dependent macromolecule catabolic process	GO:0043632	133	0.038	Mouse
cell fate commitment	GO:0045165	210	0.038
cognition	GO:0050890	149	0.037
cellular carbohydrate metabolic process	GO:0044262	119	0.037
positive regulation of steroid biosynthetic process	GO:0010893	4	0.037
response to metal ion	GO:0010038	47	0.037
t cell activation	GO:0042110	289	0.037
positive regulation of binding	GO:0051099	49	0.037
divalent inorganic cation homeostasis	GO:0072507	138	0.036	Mouse
negative regulation of cell development	GO:0010721	169	0.036	Fly
cellular response to biotic stimulus	GO:0071216	92	0.036
peptidyl amino acid modification	GO:0018193	336	0.036
purine nucleotide biosynthetic process	GO:0006164	65	0.036	Mouse
chromatin modification	GO:0016568	187	0.036
immune effector process	GO:0002252	321	0.035
lymphocyte differentiation	GO:0030098	242	0.035
cellular polysaccharide metabolic process	GO:0044264	38	0.035
small molecule biosynthetic process	GO:0044283	132	0.035
positive regulation of nucleotide metabolic process	GO:0045981	114	0.035	Mouse
p38mapk cascade	GO:0038066	4	0.035
ribonucleotide catabolic process	GO:0009261	208	0.035	Mouse Fly
nucleotide metabolic process	GO:0009117	332	0.034	Mouse Fly
acetylcholine secretion neurotransmission	GO:0014055	2	0.034	Worm
peptidyl tyrosine modification	GO:0018212	145	0.034
regulation of steroid biosynthetic process	GO:0050810	26	0.034
covalent chromatin modification	GO:0016569	163	0.034
ion transmembrane transport	GO:0034220	361	0.034
regulation of lipid kinase activity	GO:0043550	14	0.034
protein localization to plasma membrane	GO:0072659	57	0.034
cardiocyte differentiation	GO:0035051	87	0.034
embryonic placenta development	GO:0001892	98	0.034
lateral inhibition	GO:0046331	1	0.034
regulation of organelle organization	GO:0033043	289	0.034
regulation of cellular component biogenesis	GO:0044087	181	0.033
vesicle localization	GO:0051648	86	0.033
reactive oxygen species biosynthetic process	GO:1903409	8	0.033
regulation of muscle tissue development	GO:1901861	97	0.033
protein localization to membrane	GO:0072657	108	0.033
neuronal action potential	GO:0019228	54	0.033
cellular response to hormone stimulus	GO:0032870	150	0.033
cellular response to carbohydrate stimulus	GO:0071322	50	0.033
purine nucleoside catabolic process	GO:0006152	205	0.033	Mouse Fly
adenylate cyclase activating g protein coupled receptor signaling pathway	GO:0007189	30	0.032	Mouse
chromatin organization	GO:0006325	206	0.032
positive regulation of cytosolic calcium ion concentration	GO:0007204	65	0.032	Mouse
intracellular receptor signaling pathway	GO:0030522	74	0.032
organic hydroxy compound metabolic process	GO:1901615	203	0.032
g1 s transition of mitotic cell cycle	GO:0000082	57	0.032
circadian rhythm	GO:0007623	114	0.032
regulation of fat cell differentiation	GO:0045598	81	0.032
negative regulation of cell size	GO:0045792	3	0.032
positive regulation of cell projection organization	GO:0031346	95	0.032
multicellular organismal signaling	GO:0035637	91	0.032
positive regulation of osteoblast differentiation	GO:0045669	34	0.031	Mouse
myotube cell development	GO:0014904	60	0.031
nuclear import	GO:0051170	95	0.031
defense response to other organism	GO:0098542	197	0.031
spermatid development	GO:0007286	108	0.031
regulation of neuron projection development	GO:0010975	169	0.031
myotube differentiation	GO:0014902	105	0.031
positive regulation of cell development	GO:0010720	237	0.030
organophosphate biosynthetic process	GO:0090407	122	0.030	Mouse
ossification	GO:0001503	216	0.030	Mouse
methylation	GO:0032259	134	0.030	Mouse
regulation of cholesterol homeostasis	GO:2000188	9	0.030
multi multicellular organism process	GO:0044706	109	0.030	Mouse Worm
erythrocyte differentiation	GO:0030218	88	0.030
regulation of endocytosis	GO:0030100	69	0.030
muscle cell development	GO:0055001	133	0.030
tube closure	GO:0060606	91	0.030
lactation	GO:0007595	25	0.030
mammary gland epithelial cell proliferation	GO:0033598	24	0.030
guanosine containing compound catabolic process	GO:1901069	144	0.030	Mouse Fly
respiratory tube development	GO:0030323	167	0.029
sensory system development	GO:0048880	3	0.029
regulation of glutamine family amino acid metabolic process	GO:0000820	1	0.029
regulation of ion transport	GO:0043269	215	0.029	Worm
ribose phosphate metabolic process	GO:0019693	291	0.029	Mouse Fly
transmembrane receptor protein tyrosine kinase signaling pathway	GO:0007169	247	0.029
response to acid chemical	GO:0001101	111	0.029
purine nucleoside triphosphate metabolic process	GO:0009144	226	0.029	Mouse Fly
purine ribonucleoside metabolic process	GO:0046128	241	0.029	Mouse Fly
steroid metabolic process	GO:0008202	119	0.029
mesonephric tubule development	GO:0072164	94	0.029
positive regulation of organelle organization	GO:0010638	128	0.029
regulation of myeloid cell differentiation	GO:0045637	96	0.028	Mouse
meiotic cell cycle	GO:0051321	122	0.028
negative regulation of cytokine production	GO:0001818	84	0.028
type i pneumocyte differentiation	GO:0060509	7	0.028
purine containing compound metabolic process	GO:0072521	311	0.028	Mouse Fly
cellular nitrogen compound catabolic process	GO:0044270	280	0.028	Mouse Fly
acylglycerol metabolic process	GO:0006639	55	0.028
regulation of purine nucleotide biosynthetic process	GO:1900371	34	0.028	Mouse
positive regulation of ossification	GO:0045778	47	0.028	Mouse
triglyceride homeostasis	GO:0070328	15	0.027
hormone metabolic process	GO:0042445	86	0.027
striated muscle cell development	GO:0055002	125	0.027
stem cell differentiation	GO:0048863	268	0.027
regulation of nucleotide catabolic process	GO:0030811	122	0.027
regulation of protein catabolic process	GO:0042176	108	0.027	Mouse
axon ensheathment	GO:0008366	76	0.027
gliogenesis	GO:0042063	141	0.027
camp metabolic process	GO:0046058	40	0.027	Mouse
positive regulation of mapk cascade	GO:0043410	170	0.027
microtubule based process	GO:0007017	236	0.027
spermatid differentiation	GO:0048515	115	0.027
steroid biosynthetic process	GO:0006694	47	0.027
response to cold	GO:0009409	19	0.027
heterocycle catabolic process	GO:0046700	280	0.027	Mouse Fly
protein ubiquitination	GO:0016567	171	0.027
embryonic skeletal system development	GO:0048706	120	0.027	Mouse
negative regulation of cell growth	GO:0030308	44	0.027
organonitrogen compound catabolic process	GO:1901565	264	0.027	Mouse Fly
fatty acid transmembrane transport	GO:1902001	1	0.027
negative regulation of nervous system development	GO:0051961	156	0.027
purine ribonucleoside catabolic process	GO:0046130	205	0.027	Mouse Fly
positive regulation of nucleotide catabolic process	GO:0030813	88	0.027
immune response activating signal transduction	GO:0002757	116	0.026
sequestering of metal ion	GO:0051238	19	0.026
purine containing compound catabolic process	GO:0072523	213	0.026	Mouse Fly
developmental cell growth	GO:0048588	84	0.026
regulation of steroid metabolic process	GO:0019218	39	0.026
development of primary male sexual characteristics	GO:0046546	88	0.026
regulation of transmembrane receptor protein serine threonine kinase signaling pathway	GO:0090092	112	0.026
positive regulation of epithelial cell proliferation	GO:0050679	68	0.026
regulation of p38mapk cascade	GO:1900744	3	0.026
hematopoietic progenitor cell differentiation	GO:0002244	143	0.025
negative regulation of transmembrane receptor protein serine threonine kinase signaling pathway	GO:0090101	61	0.025
circadian regulation of gene expression	GO:0032922	48	0.025
plasma membrane organization	GO:0007009	90	0.025
positive regulation of homeostatic process	GO:0032846	64	0.025
negative regulation of female receptivity	GO:0007621	2	0.025
leukocyte proliferation	GO:0070661	172	0.025
negative regulation of translational initiation	GO:0045947	4	0.025
chromosome segregation	GO:0007059	48	0.025
positive regulation of protein transport	GO:0051222	93	0.025
cellular calcium ion homeostasis	GO:0006874	119	0.025	Mouse
negative regulation of synapse assembly	GO:0051964	3	0.025
regulation of exocytosis	GO:0017157	61	0.025
regulation of protein complex assembly	GO:0043254	83	0.025
central nervous system neuron development	GO:0021954	67	0.025	Mouse

Gna11 disease predictions

Disease predictions are made from cross-annotation of human disease genes to the identified functional analogs in mouse and predicted with the mouse functional network.

Disease	DO term ID	Probability
cancer	DOID:162	0.098
disease of cellular proliferation	DOID:14566	0.098
endocrine system disease	DOID:28	0.080
thyroid gland disease	DOID:50	0.080
hypothyroidism	DOID:1459	0.080
disease of anatomical entity	DOID:7	0.080
organ system cancer	DOID:0050686	0.035
musculoskeletal system disease	DOID:17	0.026

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