| chromatin organization | GO:0006325 | 206 | 0.391 | |
| covalent chromatin modification | GO:0016569 | 163 | 0.237 | |
| histone modification | GO:0016570 | 159 | 0.171 | |
| macromolecule catabolic process | GO:0009057 | 281 | 0.171 | |
| protein modification by small protein conjugation or removal | GO:0070647 | 207 | 0.128 | |
| chromatin modification | GO:0016568 | 187 | 0.121 | |
| regulation of organelle organization | GO:0033043 | 289 | 0.110 | |
| multicellular organism growth | GO:0035264 | 161 | 0.090 | |
| regulation of cell cycle process | GO:0010564 | 160 | 0.078 | |
| regulation of chromatin organization | GO:1902275 | 57 | 0.067 | |
| regulation of hydrolase activity | GO:0051336 | 246 | 0.065 | |
| regulation of histone modification | GO:0031056 | 56 | 0.064 | |
| mapk cascade | GO:0000165 | 281 | 0.063 | |
| rna processing | GO:0006396 | 105 | 0.062 | |
| rna splicing | GO:0008380 | 54 | 0.062 | |
| regulation of chromosome organization | GO:0033044 | 83 | 0.057 | |
| protein ubiquitination | GO:0016567 | 171 | 0.056 | |
| posttranscriptional regulation of gene expression | GO:0010608 | 155 | 0.053 | |
| protein modification by small protein conjugation | GO:0032446 | 187 | 0.053 | |
| mrna metabolic process | GO:0016071 | 84 | 0.051 | |
| blastocyst development | GO:0001824 | 80 | 0.048 | |
| rna catabolic process | GO:0006401 | 29 | 0.047 | |
| cellular response to dna damage stimulus | GO:0006974 | 207 | 0.046 | |
| nucleoside phosphate metabolic process | GO:0006753 | 338 | 0.044 | |
| compound eye development | GO:0048749 | 1 | 0.044 | |
| germ cell development | GO:0007281 | 185 | 0.044 | |
| negative regulation of protein metabolic process | GO:0051248 | 282 | 0.043 | |
| regulation of mrna processing | GO:0050684 | 41 | 0.042 | |
| positive regulation of growth | GO:0045927 | 104 | 0.038 | |
| dna metabolic process | GO:0006259 | 303 | 0.037 | |
| heterocycle catabolic process | GO:0046700 | 280 | 0.037 | |
| ubiquitin dependent protein catabolic process | GO:0006511 | 129 | 0.036 | |
| negative regulation of cellular protein metabolic process | GO:0032269 | 247 | 0.036 | |
| appendage development | GO:0048736 | 166 | 0.034 | |
| homeostasis of number of cells | GO:0048872 | 210 | 0.034 | |
| organelle assembly | GO:0070925 | 177 | 0.034 | |
| regulation of cell cycle | GO:0051726 | 281 | 0.034 | |
| cellular homeostasis | GO:0019725 | 240 | 0.033 | |
| mrna transport | GO:0051028 | 13 | 0.033 | |
| rna interference | GO:0016246 | 2 | 0.033 | |
| cellular nitrogen compound catabolic process | GO:0044270 | 280 | 0.032 | |
| limb development | GO:0060173 | 166 | 0.031 | |
| endocytosis | GO:0006897 | 168 | 0.030 | |
| regulation of chromatin modification | GO:1903308 | 57 | 0.030 | |
| cellular amino acid metabolic process | GO:0006520 | 103 | 0.030 | |
| histone deubiquitination | GO:0016578 | 2 | 0.029 | |
| aromatic compound catabolic process | GO:0019439 | 286 | 0.029 | |
| cognition | GO:0050890 | 149 | 0.029 | |
| learning or memory | GO:0007611 | 148 | 0.029 | |
| translation | GO:0006412 | 93 | 0.029 | |
| cellular macromolecule catabolic process | GO:0044265 | 206 | 0.028 | |
| histone methylation | GO:0016571 | 71 | 0.028 | |
| camera type eye development | GO:0043010 | 266 | 0.028 | |
| regulation of protein maturation | GO:1903317 | 96 | 0.028 | |
| protein processing | GO:0016485 | 163 | 0.028 | |
| nuclear division | GO:0000280 | 158 | 0.027 | |
| negative regulation of protein maturation | GO:1903318 | 79 | 0.027 | |
| rna splicing via transesterification reactions | GO:0000375 | 43 | 0.027 | |
| organic cyclic compound catabolic process | GO:1901361 | 295 | 0.027 | |
| purine ribonucleotide metabolic process | GO:0009150 | 290 | 0.027 | |
| negative regulation of organelle organization | GO:0010639 | 90 | 0.026 | |
| negative regulation of cellular component organization | GO:0051129 | 194 | 0.026 | |
| regulation of mitotic cell cycle | GO:0007346 | 126 | 0.026 | |
| female gamete generation | GO:0007292 | 74 | 0.026 | |
| regulation of protein stability | GO:0031647 | 52 | 0.026 | |
| locomotory behavior | GO:0007626 | 195 | 0.025 | |
| histone lysine methylation | GO:0034968 | 50 | 0.025 | |
| nucleobase containing small molecule metabolic process | GO:0055086 | 352 | 0.025 | |
| spermatogenesis | GO:0007283 | 284 | 0.025 | |
| intracellular mrna localization | GO:0008298 | 4 | 0.025 | |
| regulation of meiotic cell cycle | GO:0051445 | 34 | 0.025 | |
| regulation of cellular ketone metabolic process | GO:0010565 | 66 | 0.024 | |
| purine containing compound metabolic process | GO:0072521 | 311 | 0.024 | |
| organonitrogen compound catabolic process | GO:1901565 | 264 | 0.024 | |
| purine nucleotide metabolic process | GO:0006163 | 302 | 0.024 | |
| regulation of synaptic growth at neuromuscular junction | GO:0008582 | 4 | 0.024 | |
| regulation of translation | GO:0006417 | 71 | 0.024 | |
| protein modification by small protein removal | GO:0070646 | 21 | 0.024 | |
| oogenesis | GO:0048477 | 56 | 0.023 | |
| digestive system development | GO:0055123 | 200 | 0.023 | |
| organelle fission | GO:0048285 | 170 | 0.023 | |
| positive regulation of cellular amine metabolic process | GO:0033240 | 5 | 0.023 | |
| positive regulation of organelle organization | GO:0010638 | 128 | 0.023 | |
| mrna catabolic process | GO:0006402 | 22 | 0.022 | |
| stem cell development | GO:0048864 | 219 | 0.022 | |
| cytoplasmic transport | GO:0016482 | 234 | 0.022 | |
| negative regulation of proteolysis | GO:0045861 | 74 | 0.022 | |
| lateral inhibition | GO:0046331 | 1 | 0.021 | |
| phagocytosis | GO:0006909 | 66 | 0.021 | |
| protein maturation | GO:0051604 | 176 | 0.021 | |
| protein deacetylation | GO:0006476 | 32 | 0.021 | |
| cell division | GO:0051301 | 120 | 0.021 | |
| regulation of cellular amine metabolic process | GO:0033238 | 20 | 0.021 | |
| negative regulation of molecular function | GO:0044092 | 258 | 0.021 | |
| sensory perception | GO:0007600 | 245 | 0.021 | |
| meiotic cell cycle process | GO:1903046 | 77 | 0.021 | |
| central nervous system neuron differentiation | GO:0021953 | 162 | 0.020 | |
| regulation of proteolysis | GO:0030162 | 164 | 0.020 | |
| protein methylation | GO:0006479 | 81 | 0.020 | |
| histone deacetylation | GO:0016575 | 26 | 0.020 | |
| cation homeostasis | GO:0055080 | 212 | 0.020 | |
| modification dependent macromolecule catabolic process | GO:0043632 | 133 | 0.020 | |
| intracellular protein transport | GO:0006886 | 204 | 0.020 | |
| cell cycle checkpoint | GO:0000075 | 47 | 0.020 | |
| amine metabolic process | GO:0009308 | 45 | 0.019 | |
| regulation of mapk cascade | GO:0043408 | 248 | 0.019 | |
| stem cell differentiation | GO:0048863 | 268 | 0.019 | |
| skeletal system development | GO:0001501 | 356 | 0.019 | |
| cell type specific apoptotic process | GO:0097285 | 268 | 0.019 | |
| negative regulation of intracellular signal transduction | GO:1902532 | 167 | 0.019 | |
| protein autophosphorylation | GO:0046777 | 61 | 0.018 | |
| regulation of cytoskeleton organization | GO:0051493 | 122 | 0.018 | |
| protein catabolic process | GO:0030163 | 221 | 0.018 | |
| maintenance of location | GO:0051235 | 89 | 0.018 | |
| purine ribonucleoside triphosphate catabolic process | GO:0009207 | 199 | 0.018 | |
| modification dependent protein catabolic process | GO:0019941 | 133 | 0.018 | |
| regulation of rna splicing | GO:0043484 | 37 | 0.018 | |
| purine nucleoside triphosphate metabolic process | GO:0009144 | 226 | 0.018 | |
| microtubule cytoskeleton organization | GO:0000226 | 157 | 0.018 | |
| cellular chemical homeostasis | GO:0055082 | 215 | 0.018 | |
| purine ribonucleotide catabolic process | GO:0009154 | 208 | 0.018 | |
| cellular amine metabolic process | GO:0044106 | 44 | 0.018 | |
| multi multicellular organism process | GO:0044706 | 109 | 0.018 | |
| cellular ion homeostasis | GO:0006873 | 165 | 0.018 | |
| positive regulation of chromatin modification | GO:1903310 | 28 | 0.017 | |
| cellular ketone metabolic process | GO:0042180 | 84 | 0.017 | |
| regulation of cellular component size | GO:0032535 | 121 | 0.017 | |
| rhythmic process | GO:0048511 | 174 | 0.017 | |
| ear development | GO:0043583 | 200 | 0.017 | |
| oocyte axis specification | GO:0007309 | 2 | 0.017 | |
| protein localization to organelle | GO:0033365 | 185 | 0.016 | |
| divalent inorganic cation homeostasis | GO:0072507 | 138 | 0.016 | |
| cellular protein catabolic process | GO:0044257 | 155 | 0.016 | |
| negative regulation of proteolysis involved in cellular protein catabolic process | GO:1903051 | 22 | 0.016 | |
| monoubiquitinated protein deubiquitination | GO:0035520 | 2 | 0.016 | |
| negative regulation of hydrolase activity | GO:0051346 | 71 | 0.016 | |
| glycosyl compound metabolic process | GO:1901657 | 246 | 0.016 | |
| regulation of anatomical structure size | GO:0090066 | 178 | 0.016 | |
| peptidyl lysine methylation | GO:0018022 | 29 | 0.016 | |
| metal ion homeostasis | GO:0055065 | 189 | 0.016 | |
| purine ribonucleoside catabolic process | GO:0046130 | 205 | 0.015 | |
| transmembrane receptor protein serine threonine kinase signaling pathway | GO:0007178 | 194 | 0.015 | |
| positive regulation of cellular amino acid metabolic process | GO:0045764 | 3 | 0.015 | |
| hepaticobiliary system development | GO:0061008 | 67 | 0.015 | |
| regulation of transcription by chromatin organization | GO:0034401 | 0 | 0.015 | |
| innate immune response | GO:0045087 | 157 | 0.015 | |
| apoptotic signaling pathway | GO:0097190 | 306 | 0.015 | |
| meiotic cell cycle | GO:0051321 | 122 | 0.015 | |
| uterus morphogenesis | GO:0061038 | 2 | 0.015 | |
| negative regulation of cellular catabolic process | GO:0031330 | 47 | 0.015 | |
| rna splicing via transesterification reactions with bulged adenosine as nucleophile | GO:0000377 | 43 | 0.015 | |
| regulation of cellular amino acid metabolic process | GO:0006521 | 5 | 0.015 | |
| bone development | GO:0060348 | 120 | 0.015 | |
| cellular metal ion homeostasis | GO:0006875 | 151 | 0.015 | |
| ribose phosphate metabolic process | GO:0019693 | 291 | 0.015 | |
| nucleus organization | GO:0006997 | 45 | 0.014 | |
| gonad development | GO:0008406 | 141 | 0.014 | |
| purine nucleoside triphosphate catabolic process | GO:0009146 | 203 | 0.014 | |
| negative regulation of mapk cascade | GO:0043409 | 65 | 0.014 | |
| rna localization | GO:0006403 | 23 | 0.014 | |
| nucleoside phosphate catabolic process | GO:1901292 | 222 | 0.014 | |
| regulation of protein complex assembly | GO:0043254 | 83 | 0.014 | |
| nucleocytoplasmic transport | GO:0006913 | 139 | 0.014 | |
| development of primary sexual characteristics | GO:0045137 | 143 | 0.014 | |
| microtubule based process | GO:0007017 | 236 | 0.014 | |
| carbohydrate metabolic process | GO:0005975 | 230 | 0.014 | |
| regulation of nuclear division | GO:0051783 | 56 | 0.014 | |
| proteasome mediated ubiquitin dependent protein catabolic process | GO:0043161 | 88 | 0.014 | |
| regulation of cytoplasmic transport | GO:1903649 | 112 | 0.014 | |
| cellular protein complex assembly | GO:0043623 | 116 | 0.014 | |
| nucleotide metabolic process | GO:0009117 | 332 | 0.014 | |
| mrna processing | GO:0006397 | 63 | 0.014 | |
| morphogenesis of embryonic epithelium | GO:0016331 | 159 | 0.013 | |
| positive regulation of chromosome organization | GO:2001252 | 33 | 0.013 | |
| sensory organ morphogenesis | GO:0090596 | 242 | 0.013 | |
| regulation of mitotic cell cycle phase transition | GO:1901990 | 73 | 0.013 | |
| skeletal muscle organ development | GO:0060538 | 163 | 0.013 | |
| leukocyte mediated immunity | GO:0002443 | 174 | 0.013 | |
| synapse organization | GO:0050808 | 125 | 0.013 | |
| posttranscriptional gene silencing | GO:0016441 | 10 | 0.013 | |
| histone h3 k9 methylation | GO:0051567 | 17 | 0.013 | |
| epidermal growth factor receptor signaling pathway | GO:0007173 | 28 | 0.013 | |
| gastrulation | GO:0007369 | 116 | 0.013 | |
| chromatin silencing at rdna | GO:0000183 | 3 | 0.013 | |
| actin cytoskeleton organization | GO:0030036 | 220 | 0.013 | |
| regulation of cellular response to stress | GO:0080135 | 159 | 0.013 | |
| male gamete generation | GO:0048232 | 285 | 0.013 | |
| regulation of protein processing | GO:0070613 | 96 | 0.013 | |
| regulation of proteolysis involved in cellular protein catabolic process | GO:1903050 | 56 | 0.012 | |
| cellular calcium ion homeostasis | GO:0006874 | 119 | 0.012 | |
| purine nucleoside catabolic process | GO:0006152 | 205 | 0.012 | |
| appendage morphogenesis | GO:0035107 | 149 | 0.012 | |
| regulation of neuron differentiation | GO:0045664 | 281 | 0.012 | |
| spermatid development | GO:0007286 | 108 | 0.012 | |
| b cell activation | GO:0042113 | 161 | 0.012 | |
| skeletal system morphogenesis | GO:0048705 | 203 | 0.012 | |
| macromolecule deacylation | GO:0098732 | 37 | 0.012 | |
| nucleotide catabolic process | GO:0009166 | 217 | 0.012 | |
| ribonucleoside catabolic process | GO:0042454 | 206 | 0.012 | |
| sensory perception of sound | GO:0007605 | 97 | 0.012 | |
| lung development | GO:0030324 | 164 | 0.012 | |
| carbohydrate derivative biosynthetic process | GO:1901137 | 183 | 0.012 | |
| central nervous system projection neuron axonogenesis | GO:0021952 | 21 | 0.012 | |
| myeloid cell homeostasis | GO:0002262 | 114 | 0.012 | |
| protein localization to nucleus | GO:0034504 | 121 | 0.012 | |
| regulation of mrna metabolic process | GO:1903311 | 43 | 0.012 | |
| regulation of cell migration | GO:0030334 | 219 | 0.012 | |
| cation transmembrane transport | GO:0098655 | 266 | 0.012 | |
| myeloid leukocyte activation | GO:0002274 | 83 | 0.012 | Mouse |
| cellular response to lipid | GO:0071396 | 145 | 0.012 | |
| regulation of actin filament based process | GO:0032970 | 99 | 0.012 | |
| regulation of histone methylation | GO:0031060 | 30 | 0.012 | |
| nitrogen compound transport | GO:0071705 | 271 | 0.011 | |
| lipid localization | GO:0010876 | 126 | 0.011 | |
| negative regulation of neuron differentiation | GO:0045665 | 101 | 0.011 | |
| heart morphogenesis | GO:0003007 | 178 | 0.011 | |
| organic hydroxy compound metabolic process | GO:1901615 | 203 | 0.011 | |
| regulation of rna export from nucleus | GO:0046831 | 4 | 0.011 | |
| negative regulation of protein modification process | GO:0031400 | 163 | 0.011 | |
| carbohydrate derivative catabolic process | GO:1901136 | 231 | 0.011 | |
| negative regulation of immune system process | GO:0002683 | 209 | 0.011 | |
| nucleoside triphosphate metabolic process | GO:0009141 | 230 | 0.011 | |
| digestive tract development | GO:0048565 | 190 | 0.011 | |
| negative regulation of cell cycle process | GO:0010948 | 69 | 0.011 | |
| organophosphate biosynthetic process | GO:0090407 | 122 | 0.011 | |
| regulation of protein catabolic process | GO:0042176 | 108 | 0.011 | |
| inorganic ion transmembrane transport | GO:0098660 | 234 | 0.011 | |
| nucleoside metabolic process | GO:0009116 | 246 | 0.011 | |
| neural tube development | GO:0021915 | 160 | 0.011 | |
| regulation of intracellular transport | GO:0032386 | 159 | 0.011 | |
| positive regulation of mapk cascade | GO:0043410 | 170 | 0.011 | |
| regulation of viral transcription | GO:0046782 | 3 | 0.011 | |
| striated muscle tissue development | GO:0014706 | 293 | 0.011 | |
| purine ribonucleoside metabolic process | GO:0046128 | 241 | 0.011 | |
| neural tube closure | GO:0001843 | 90 | 0.011 | |
| synaptic transmission | GO:0007268 | 329 | 0.011 | |
| ribonucleoside triphosphate metabolic process | GO:0009199 | 220 | 0.011 | |
| regulation of establishment of protein localization | GO:0070201 | 181 | 0.011 | |
| purine nucleoside monophosphate metabolic process | GO:0009126 | 81 | 0.011 | |
| nuclear transport | GO:0051169 | 139 | 0.011 | |
| establishment of protein localization to organelle | GO:0072594 | 118 | 0.010 | |
| negative regulation of chromosome organization | GO:2001251 | 30 | 0.010 | |
| mrna splicing via spliceosome | GO:0000398 | 43 | 0.010 | |
| cerebellar purkinje cell layer morphogenesis | GO:0021692 | 14 | 0.010 | |
| cellular lipid metabolic process | GO:0044255 | 323 | 0.010 | |
| regulation of cellular catabolic process | GO:0031329 | 242 | 0.010 | |
| small gtpase mediated signal transduction | GO:0007264 | 97 | 0.010 | |
| peptidyl amino acid modification | GO:0018193 | 336 | 0.010 | |
| embryonic appendage morphogenesis | GO:0035113 | 126 | 0.010 | |
| purine ribonucleoside triphosphate metabolic process | GO:0009205 | 220 | 0.010 | |
| negative regulation of mesenchymal cell proliferation | GO:0072201 | 3 | 0.010 | |
| central nervous system neuron development | GO:0021954 | 67 | 0.010 | |
| positive regulation of cytoskeleton organization | GO:0051495 | 49 | 0.010 | |
| negative regulation of phosphate metabolic process | GO:0045936 | 184 | 0.010 | |
| protein polyubiquitination | GO:0000209 | 33 | 0.010 | |
| signal transduction downstream of smoothened | GO:0007227 | 4 | 0.010 | |
| body morphogenesis | GO:0010171 | 45 | 0.010 | |
| ribonucleotide metabolic process | GO:0009259 | 291 | 0.010 | |
| negative regulation of cell development | GO:0010721 | 169 | 0.010 | |
| histone h4 k20 methylation | GO:0034770 | 8 | 0.010 | |