| spermatogenesis | GO:0007283 | 284 | 0.158 | |
| guanosine containing compound metabolic process | GO:1901068 | 144 | 0.105 | |
| male gamete generation | GO:0048232 | 285 | 0.094 | |
| gtp metabolic process | GO:0046039 | 144 | 0.077 | |
| regulation of apoptotic signaling pathway | GO:2001233 | 197 | 0.073 | |
| nucleoside phosphate metabolic process | GO:0006753 | 338 | 0.072 | |
| regulation of hydrolase activity | GO:0051336 | 246 | 0.067 | |
| ribose phosphate metabolic process | GO:0019693 | 291 | 0.066 | |
| apoptotic signaling pathway | GO:0097190 | 306 | 0.064 | Mouse |
| negative regulation of protein metabolic process | GO:0051248 | 282 | 0.064 | |
| purine ribonucleoside catabolic process | GO:0046130 | 205 | 0.063 | |
| regulation of vesicle mediated transport | GO:0060627 | 139 | 0.063 | |
| positive regulation of cell death | GO:0010942 | 224 | 0.058 | |
| regulation of nucleotide catabolic process | GO:0030811 | 122 | 0.056 | |
| nucleoside metabolic process | GO:0009116 | 246 | 0.056 | |
| regulation of cellular response to stress | GO:0080135 | 159 | 0.054 | |
| nucleoside triphosphate metabolic process | GO:0009141 | 230 | 0.053 | |
| purine containing compound catabolic process | GO:0072523 | 213 | 0.052 | |
| ras protein signal transduction | GO:0007265 | 77 | 0.052 | |
| myeloid cell differentiation | GO:0030099 | 233 | 0.051 | |
| regulation of purine nucleotide catabolic process | GO:0033121 | 122 | 0.050 | |
| heterocycle catabolic process | GO:0046700 | 280 | 0.050 | |
| positive regulation of cellular catabolic process | GO:0031331 | 148 | 0.049 | |
| nucleoside catabolic process | GO:0009164 | 206 | 0.048 | |
| dna metabolic process | GO:0006259 | 303 | 0.048 | |
| retrograde transport endosome to golgi | GO:0042147 | 2 | 0.047 | |
| reactive oxygen species metabolic process | GO:0072593 | 84 | 0.047 | |
| guanosine containing compound catabolic process | GO:1901069 | 144 | 0.046 | |
| regulation of organelle organization | GO:0033043 | 289 | 0.046 | |
| cellular macromolecule catabolic process | GO:0044265 | 206 | 0.045 | Human |
| exocytosis | GO:0006887 | 121 | 0.044 | |
| purine nucleoside metabolic process | GO:0042278 | 241 | 0.042 | |
| ribonucleotide catabolic process | GO:0009261 | 208 | 0.042 | |
| glucose homeostasis | GO:0042593 | 128 | 0.042 | |
| rab protein signal transduction | GO:0032482 | 1 | 0.042 | |
| nucleoside triphosphate catabolic process | GO:0009143 | 205 | 0.041 | |
| regulation of nucleotide metabolic process | GO:0006140 | 169 | 0.041 | |
| purine nucleoside triphosphate catabolic process | GO:0009146 | 203 | 0.040 | |
| purine ribonucleoside metabolic process | GO:0046128 | 241 | 0.040 | |
| glycosyl compound catabolic process | GO:1901658 | 206 | 0.039 | |
| nucleobase containing small molecule metabolic process | GO:0055086 | 352 | 0.039 | |
| negative regulation of molecular function | GO:0044092 | 258 | 0.039 | |
| nucleoside phosphate catabolic process | GO:1901292 | 222 | 0.039 | |
| nucleotide metabolic process | GO:0009117 | 332 | 0.039 | |
| purine ribonucleoside triphosphate metabolic process | GO:0009205 | 220 | 0.038 | |
| regulation of cell migration | GO:0030334 | 219 | 0.037 | |
| purine containing compound metabolic process | GO:0072521 | 311 | 0.037 | |
| organelle fission | GO:0048285 | 170 | 0.037 | |
| gtp catabolic process | GO:0006184 | 143 | 0.036 | |
| positive regulation of purine nucleotide metabolic process | GO:1900544 | 114 | 0.036 | |
| positive regulation of apoptotic signaling pathway | GO:2001235 | 95 | 0.035 | |
| positive regulation of purine nucleotide catabolic process | GO:0033123 | 88 | 0.035 | |
| positive regulation of nucleotide metabolic process | GO:0045981 | 114 | 0.035 | |
| positive regulation of programmed cell death | GO:0043068 | 218 | 0.034 | |
| germ cell development | GO:0007281 | 185 | 0.034 | |
| small gtpase mediated signal transduction | GO:0007264 | 97 | 0.034 | |
| fat cell differentiation | GO:0045444 | 160 | 0.033 | Mouse |
| nucleotide catabolic process | GO:0009166 | 217 | 0.033 | |
| response to organonitrogen compound | GO:0010243 | 246 | 0.033 | |
| ribonucleoside triphosphate catabolic process | GO:0009203 | 199 | 0.033 | |
| ribonucleoside triphosphate metabolic process | GO:0009199 | 220 | 0.033 | |
| positive regulation of hydrolase activity | GO:0051345 | 148 | 0.033 | |
| synaptic transmission | GO:0007268 | 329 | 0.032 | |
| regulation of membrane potential | GO:0042391 | 192 | 0.032 | |
| negative regulation of translational initiation | GO:0045947 | 4 | 0.031 | |
| organophosphate catabolic process | GO:0046434 | 232 | 0.031 | |
| glycosyl compound metabolic process | GO:1901657 | 246 | 0.030 | |
| positive regulation of gtpase activity | GO:0043547 | 85 | 0.030 | |
| purine nucleoside triphosphate metabolic process | GO:0009144 | 226 | 0.030 | |
| ribonucleoside metabolic process | GO:0009119 | 245 | 0.029 | |
| cellular homeostasis | GO:0019725 | 240 | 0.029 | |
| regulation of transferase activity | GO:0051338 | 263 | 0.029 | |
| organonitrogen compound catabolic process | GO:1901565 | 264 | 0.029 | |
| negative regulation of cellular component organization | GO:0051129 | 194 | 0.028 | |
| microtubule based process | GO:0007017 | 236 | 0.027 | |
| regulation of cellular amino acid metabolic process | GO:0006521 | 5 | 0.027 | |
| cellular amine metabolic process | GO:0044106 | 44 | 0.026 | |
| immune effector process | GO:0002252 | 321 | 0.026 | Human |
| organelle assembly | GO:0070925 | 177 | 0.026 | |
| positive regulation of nucleotide catabolic process | GO:0030813 | 88 | 0.026 | |
| purine nucleotide catabolic process | GO:0006195 | 211 | 0.026 | |
| establishment or maintenance of cytoskeleton polarity | GO:0030952 | 2 | 0.025 | |
| aromatic compound catabolic process | GO:0019439 | 286 | 0.025 | |
| posttranscriptional regulation of gene expression | GO:0010608 | 155 | 0.025 | |
| purine nucleotide metabolic process | GO:0006163 | 302 | 0.025 | |
| positive regulation of nucleoside metabolic process | GO:0045979 | 91 | 0.025 | |
| purine ribonucleotide metabolic process | GO:0009150 | 290 | 0.025 | |
| cellular chemical homeostasis | GO:0055082 | 215 | 0.025 | |
| regulation of cellular catabolic process | GO:0031329 | 242 | 0.025 | |
| cell type specific apoptotic process | GO:0097285 | 268 | 0.024 | |
| negative regulation of phosphate metabolic process | GO:0045936 | 184 | 0.024 | |
| positive regulation of secretion | GO:0051047 | 130 | 0.024 | |
| regulation of secretion | GO:0051046 | 274 | 0.024 | |
| response to peptide | GO:1901652 | 136 | 0.024 | |
| stem cell differentiation | GO:0048863 | 268 | 0.024 | |
| ribonucleotide metabolic process | GO:0009259 | 291 | 0.024 | |
| meiotic cell cycle | GO:0051321 | 122 | 0.023 | |
| protein localization to chromatin | GO:0071168 | 3 | 0.023 | |
| oocyte construction | GO:0007308 | 2 | 0.022 | |
| peptide transport | GO:0015833 | 133 | 0.022 | |
| cellular nitrogen compound catabolic process | GO:0044270 | 280 | 0.022 | |
| carbohydrate homeostasis | GO:0033500 | 128 | 0.022 | |
| positive regulation of cellular amino acid metabolic process | GO:0045764 | 3 | 0.022 | |
| positive regulation of organelle organization | GO:0010638 | 128 | 0.022 | |
| protein modification by small protein conjugation or removal | GO:0070647 | 207 | 0.022 | |
| regulation of mapk cascade | GO:0043408 | 248 | 0.021 | |
| negative regulation of apoptotic signaling pathway | GO:2001234 | 104 | 0.021 | |
| transmembrane transport | GO:0055085 | 412 | 0.021 | |
| regulation of endocytosis | GO:0030100 | 69 | 0.021 | |
| long term synaptic potentiation | GO:0060291 | 25 | 0.020 | |
| regulation of protein localization | GO:0032880 | 231 | 0.020 | |
| regulation of purine nucleotide metabolic process | GO:1900542 | 169 | 0.020 | |
| ribonucleoside catabolic process | GO:0042454 | 206 | 0.020 | |
| negative regulation of cell cycle | GO:0045786 | 123 | 0.020 | |
| positive regulation of apoptotic process | GO:0043065 | 217 | 0.020 | |
| establishment of synaptic vesicle localization | GO:0097480 | 57 | 0.020 | |
| amine metabolic process | GO:0009308 | 45 | 0.020 | |
| extrinsic apoptotic signaling pathway | GO:0097191 | 126 | 0.020 | |
| positive regulation of gtp catabolic process | GO:0033126 | 85 | 0.020 | |
| negative regulation of cellular protein metabolic process | GO:0032269 | 247 | 0.020 | |
| regulation of cellular component biogenesis | GO:0044087 | 181 | 0.019 | |
| regulation of cell activation | GO:0050865 | 289 | 0.019 | |
| purine nucleoside catabolic process | GO:0006152 | 205 | 0.019 | |
| divalent inorganic cation transport | GO:0072511 | 178 | 0.019 | |
| response to peptide hormone | GO:0043434 | 127 | 0.019 | |
| cellular amino acid metabolic process | GO:0006520 | 103 | 0.019 | |
| regulation of cellular ketone metabolic process | GO:0010565 | 66 | 0.019 | |
| cellular metal ion homeostasis | GO:0006875 | 151 | 0.019 | |
| regulation of peptidase activity | GO:0052547 | 96 | 0.019 | |
| negative regulation of protein modification process | GO:0031400 | 163 | 0.018 | |
| regulation of ras gtpase activity | GO:0032318 | 88 | 0.018 | |
| dna endoreduplication | GO:0042023 | 4 | 0.018 | |
| regulation of gtp catabolic process | GO:0033124 | 113 | 0.018 | |
| regulation of lymphocyte activation | GO:0051249 | 240 | 0.018 | |
| blood circulation | GO:0008015 | 195 | 0.018 | Zebrafish |
| transmission of nerve impulse | GO:0019226 | 76 | 0.018 | |
| protein ubiquitination | GO:0016567 | 171 | 0.018 | |
| regionalization | GO:0003002 | 337 | 0.017 | |
| positive regulation of cellular amine metabolic process | GO:0033240 | 5 | 0.017 | |
| exosomal secretion | GO:1990182 | 1 | 0.017 | |
| nitrogen compound transport | GO:0071705 | 271 | 0.017 | |
| negative regulation of phosphorylation | GO:0042326 | 166 | 0.017 | |
| regulation of ras protein signal transduction | GO:0046578 | 114 | 0.017 | |
| cellular response to hormone stimulus | GO:0032870 | 150 | 0.017 | |
| wnt signaling pathway | GO:0016055 | 188 | 0.017 | |
| response to inorganic substance | GO:0010035 | 96 | 0.017 | |
| cellular ketone metabolic process | GO:0042180 | 84 | 0.017 | |
| amide transport | GO:0042886 | 138 | 0.017 | |
| regulation of kinase activity | GO:0043549 | 249 | 0.016 | |
| gonad development | GO:0008406 | 141 | 0.016 | |
| histone lysine demethylation | GO:0070076 | 13 | 0.016 | |
| purine ribonucleoside triphosphate catabolic process | GO:0009207 | 199 | 0.016 | |
| synaptic vesicle transport | GO:0048489 | 57 | 0.016 | |
| monocarboxylic acid metabolic process | GO:0032787 | 191 | 0.016 | |
| microtubule cytoskeleton organization | GO:0000226 | 157 | 0.016 | |
| protein lipidation | GO:0006497 | 28 | 0.016 | |
| developmental maturation | GO:0021700 | 193 | 0.016 | |
| proteolysis involved in cellular protein catabolic process | GO:0051603 | 147 | 0.016 | |
| regulation of cell motility | GO:2000145 | 236 | 0.016 | |
| negative regulation of cell proliferation | GO:0008285 | 296 | 0.016 | |
| cellular response to organonitrogen compound | GO:0071417 | 145 | 0.016 | |
| regulation of response to wounding | GO:1903034 | 189 | 0.016 | |
| protein processing | GO:0016485 | 163 | 0.016 | |
| leukocyte differentiation | GO:0002521 | 342 | 0.015 | |
| cell adhesion | GO:0007155 | 329 | 0.015 | |
| protein modification by small protein conjugation | GO:0032446 | 187 | 0.015 | |
| macromolecule catabolic process | GO:0009057 | 281 | 0.015 | Human |
| glucose metabolic process | GO:0006006 | 92 | 0.015 | |
| granzyme mediated apoptotic signaling pathway | GO:0008626 | 1 | 0.015 | |
| establishment or maintenance of microtubule cytoskeleton polarity | GO:0030951 | 1 | 0.015 | |
| cellular protein catabolic process | GO:0044257 | 155 | 0.015 | Human |
| regulation of intracellular transport | GO:0032386 | 159 | 0.015 | |
| carbohydrate derivative biosynthetic process | GO:1901137 | 183 | 0.015 | |
| positive regulation of ras gtpase activity | GO:0032320 | 65 | 0.015 | |
| regulation of inflammatory response | GO:0050727 | 147 | 0.015 | |
| signal transduction in absence of ligand | GO:0038034 | 55 | 0.015 | |
| mitochondrial outer membrane permeabilization involved in programmed cell death | GO:1902686 | 11 | 0.014 | |
| erythrocyte differentiation | GO:0030218 | 88 | 0.014 | |
| regulation of binding | GO:0051098 | 111 | 0.014 | |
| establishment of organelle localization | GO:0051656 | 122 | 0.014 | |
| carbohydrate derivative catabolic process | GO:1901136 | 231 | 0.014 | |
| positive regulation of cell adhesion | GO:0045785 | 80 | 0.014 | |
| vesicle localization | GO:0051648 | 86 | 0.014 | |
| protein localization to organelle | GO:0033365 | 185 | 0.014 | |
| negative regulation of organelle organization | GO:0010639 | 90 | 0.014 | |
| modification dependent protein catabolic process | GO:0019941 | 133 | 0.014 | |
| small molecule biosynthetic process | GO:0044283 | 132 | 0.014 | |
| regulation of exocytosis | GO:0017157 | 61 | 0.014 | |
| regulation of t cell activation | GO:0050863 | 170 | 0.014 | |
| neuron death | GO:0070997 | 154 | 0.014 | |
| metal ion homeostasis | GO:0055065 | 189 | 0.013 | |
| intracellular protein transport | GO:0006886 | 204 | 0.013 | |
| protein catabolic process | GO:0030163 | 221 | 0.013 | Human |
| response to oxygen levels | GO:0070482 | 62 | 0.013 | |
| regulation of protein processing | GO:0070613 | 96 | 0.013 | |
| multicellular organismal signaling | GO:0035637 | 91 | 0.013 | |
| development of primary sexual characteristics | GO:0045137 | 143 | 0.013 | |
| negative regulation of phosphorus metabolic process | GO:0010563 | 184 | 0.013 | |
| myeloid cell homeostasis | GO:0002262 | 114 | 0.013 | |
| spermatid differentiation | GO:0048515 | 115 | 0.013 | |
| appendage development | GO:0048736 | 166 | 0.013 | |
| generation of precursor metabolites and energy | GO:0006091 | 103 | 0.013 | |
| protein maturation | GO:0051604 | 176 | 0.013 | |
| regulation of cell adhesion | GO:0030155 | 154 | 0.013 | |
| memory | GO:0007613 | 58 | 0.013 | |
| membrane organization | GO:0061024 | 245 | 0.013 | |
| positive regulation of t cell activation | GO:0050870 | 101 | 0.013 | |
| response to light stimulus | GO:0009416 | 135 | 0.013 | |
| positive regulation of protein modification process | GO:0031401 | 299 | 0.013 | |
| synaptic vesicle localization | GO:0097479 | 59 | 0.013 | |
| intrinsic apoptotic signaling pathway | GO:0097193 | 132 | 0.013 | Mouse |
| lymphocyte mediated immunity | GO:0002449 | 139 | 0.013 | |
| cytoplasmic transport | GO:0016482 | 234 | 0.013 | |
| hormone secretion | GO:0046879 | 128 | 0.012 | |
| mitotic cell cycle process | GO:1903047 | 159 | 0.012 | |
| cation transport | GO:0006812 | 399 | 0.012 | |
| leukocyte mediated immunity | GO:0002443 | 174 | 0.012 | |
| single organism cell adhesion | GO:0098602 | 156 | 0.012 | |
| t cell activation | GO:0042110 | 289 | 0.012 | |
| inflammatory response | GO:0006954 | 244 | 0.012 | |
| extrinsic apoptotic signaling pathway in absence of ligand | GO:0097192 | 55 | 0.012 | |
| canonical wnt signaling pathway | GO:0060070 | 130 | 0.012 | |
| nuclear division | GO:0000280 | 158 | 0.012 | |
| divalent metal ion transport | GO:0070838 | 172 | 0.012 | |
| cellularization | GO:0007349 | 1 | 0.012 | |
| regulation of long term synaptic potentiation | GO:1900271 | 4 | 0.012 | |
| establishment of vesicle localization | GO:0051650 | 81 | 0.012 | |
| rna processing | GO:0006396 | 105 | 0.012 | |
| positive regulation of mitochondrial membrane permeability | GO:0035794 | 12 | 0.012 | |
| regulation of synaptic growth at neuromuscular junction | GO:0008582 | 4 | 0.012 | |
| mapk cascade | GO:0000165 | 281 | 0.012 | |
| response to uv | GO:0009411 | 44 | 0.012 | |
| leukocyte proliferation | GO:0070661 | 172 | 0.012 | |
| regulation of anatomical structure size | GO:0090066 | 178 | 0.012 | |
| protein methylation | GO:0006479 | 81 | 0.012 | |
| single organismal cell cell adhesion | GO:0016337 | 131 | 0.012 | |
| anatomical structure homeostasis | GO:0060249 | 145 | 0.012 | |
| regulation of cellular amine metabolic process | GO:0033238 | 20 | 0.012 | |
| g protein coupled receptor signaling pathway | GO:0007186 | 243 | 0.012 | |
| response to molecule of bacterial origin | GO:0002237 | 143 | 0.012 | |
| membrane fusion | GO:0061025 | 38 | 0.012 | |
| oxidation reduction process | GO:0055114 | 342 | 0.012 | |
| regulation of neuron apoptotic process | GO:0043523 | 122 | 0.011 | |
| sequestering of metal ion | GO:0051238 | 19 | 0.011 | |
| rho protein signal transduction | GO:0007266 | 32 | 0.011 | |
| regulation of translation | GO:0006417 | 71 | 0.011 | |
| spermatid development | GO:0007286 | 108 | 0.011 | |
| regulation of extrinsic apoptotic signaling pathway | GO:2001236 | 77 | 0.011 | |
| chiasma assembly | GO:0051026 | 6 | 0.011 | |
| neuronal action potential | GO:0019228 | 54 | 0.011 | |
| sequestering of calcium ion | GO:0051208 | 18 | 0.011 | |
| stem cell development | GO:0048864 | 219 | 0.011 | |
| regulation of sequence specific dna binding transcription factor activity | GO:0051090 | 106 | 0.011 | |
| endomembrane system organization | GO:0010256 | 147 | 0.011 | |
| lipoprotein metabolic process | GO:0042157 | 43 | 0.011 | |
| regulation of lipid metabolic process | GO:0019216 | 118 | 0.011 | |
| tissue remodeling | GO:0048771 | 102 | 0.011 | |
| regulation of defense response | GO:0031347 | 233 | 0.011 | |
| muscle contraction | GO:0006936 | 101 | 0.011 | |
| action potential | GO:0001508 | 78 | 0.011 | |
| cognition | GO:0050890 | 149 | 0.011 | |
| muscle system process | GO:0003012 | 141 | 0.011 | |
| stem cell maintenance | GO:0019827 | 130 | 0.011 | |
| insulin secretion | GO:0030073 | 89 | 0.011 | |
| organic cyclic compound catabolic process | GO:1901361 | 295 | 0.011 | |
| actin filament based movement | GO:0030048 | 23 | 0.011 | |
| positive regulation of monocyte chemotaxis | GO:0090026 | 2 | 0.011 | |
| negative regulation of mapk cascade | GO:0043409 | 65 | 0.011 | |
| sensory perception | GO:0007600 | 245 | 0.011 | |
| purine ribonucleotide catabolic process | GO:0009154 | 208 | 0.010 | |
| positive regulation of protein kinase activity | GO:0045860 | 144 | 0.010 | |
| regulation of neuron death | GO:1901214 | 134 | 0.010 | |
| positive regulation of fibroblast growth factor receptor signaling pathway | GO:0045743 | 3 | 0.010 | |
| apoptotic mitochondrial changes | GO:0008637 | 48 | 0.010 | |
| muscle cell differentiation | GO:0042692 | 261 | 0.010 | |
| regulation of cell cycle process | GO:0010564 | 160 | 0.010 | |
| regulation of protein transport | GO:0051223 | 163 | 0.010 | |
| negative regulation of neuron death | GO:1901215 | 98 | 0.010 | |
| peptide hormone secretion | GO:0030072 | 109 | 0.010 | |
| cellular protein complex assembly | GO:0043623 | 116 | 0.010 | |
| positive regulation of myeloid cell differentiation | GO:0045639 | 43 | 0.010 | |
| angiogenesis | GO:0001525 | 201 | 0.010 | |
| demethylation | GO:0070988 | 23 | 0.010 | |
