Mus musculus

0 known processes

P4hb

prolyl 4-hydroxylase, beta polypeptide

(Aliases: Thbp,ERp59,Pdia1,PDI)

P4hb biological process predictions


Filter by process size:
Biological processGO term IDProcess sizeProbabilityFunc Analog Org
transmembrane transportGO:00550854120.227
cell adhesionGO:00071553290.201
posttranslational protein targeting to membraneGO:000662020.181
copii coated vesicle buddingGO:009011420.178
endocytosisGO:00068971680.176
male gamete generationGO:00482322850.147
Mouse
glycoprotein biosynthetic processGO:0009101890.136
endoplasmic reticulum unfolded protein responseGO:0030968190.111
Worm
cation transmembrane transportGO:00986552660.108
cytoplasmic transportGO:00164822340.104
cation transportGO:00068123990.100
protein glycosylationGO:0006486550.095
transition metal ion transportGO:0000041380.094
cation homeostasisGO:00550802120.082
regulation of phagocytosisGO:0050764330.076
copper ion homeostasisGO:005507090.076
spermatogenesisGO:00072832840.072
Mouse
positive regulation of cell deathGO:00109422240.071
response to inorganic substanceGO:0010035960.070
negative regulation of cell developmentGO:00107211690.069
response to organic cyclic compoundGO:00140701980.067
endomembrane system organizationGO:00102561470.066
negative regulation of neuron differentiationGO:00456651010.065
cellular response to topologically incorrect proteinGO:0035967250.064
Worm
gland developmentGO:00487323300.064
response to topologically incorrect proteinGO:0035966250.064
Worm
inorganic ion transmembrane transportGO:00986602340.063
posttranscriptional regulation of gene expressionGO:00106081550.062
response to endoplasmic reticulum stressGO:0034976530.061
Human Worm
response to metal ionGO:0010038470.061
regulation of protein stabilityGO:0031647520.060
negative regulation of nervous system developmentGO:00519611560.058
extracellular structure organizationGO:00430621480.057
positive regulation of endocytosisGO:0045807420.056
membrane organizationGO:00610242450.054
positive regulation of phagocytosisGO:0050766260.054
glycoprotein metabolic processGO:00091001160.054
response to testosteroneGO:003357430.053
negative regulation of protein metabolic processGO:00512482820.049
positive regulation of dendritic cell chemotaxisGO:200051010.049
regulation of translationGO:0006417710.049
regulation of vesicle mediated transportGO:00606271390.049
inositol phosphate mediated signalingGO:0048016130.048
protein targeting to erGO:004504720.048
cellular amino acid metabolic processGO:00065201030.047
Human Worm
cellular homeostasisGO:00197252400.047
regulation of neuron differentiationGO:00456642810.046
translationGO:0006412930.046
chemotaxisGO:00069352470.045
protein catabolic processGO:00301632210.045
regulation of cellular response to stressGO:00801351590.044
Human
single organism cell adhesionGO:00986021560.043
regulation of transmembrane transportGO:00347621280.043
dna metabolic processGO:00062593030.042
protein foldingGO:0006457280.042
Yeast Mouse Rat Worm
skeletal system developmentGO:00015013560.040
cellular amine metabolic processGO:0044106440.040
regulation of endocytosisGO:0030100690.040
metal ion homeostasisGO:00550651890.040
nucleobase containing small molecule metabolic processGO:00550863520.039
ion transmembrane transportGO:00342203610.039
defecationGO:003042110.039
macromolecule glycosylationGO:0043413550.039
nucleotide metabolic processGO:00091173320.038
positive regulation of programmed cell deathGO:00430682180.037
regulation of cell migrationGO:00303342190.036
response to unfolded proteinGO:0006986210.035
Worm
negative regulation of cellular protein metabolic processGO:00322692470.035
response to oxidative stressGO:00069791230.035
Human
cellular copper ion homeostasisGO:000687880.035
regulation of cellular ketone metabolic processGO:0010565660.034
carbohydrate derivative biosynthetic processGO:19011371830.034
organic hydroxy compound metabolic processGO:19016152030.034
regulation of cell adhesionGO:00301551540.033
regulation of cellular amino acid metabolic processGO:000652150.033
regulation of dendritic cell chemotaxisGO:200050810.032
protein localization to organelleGO:00333651850.032
protein hydroxylationGO:001812640.032
Human Worm
single organismal cell cell adhesionGO:00163371310.032
intra golgi vesicle mediated transportGO:000689110.031
er nucleus signaling pathwayGO:0006984270.031
Worm
purine containing compound metabolic processGO:00725213110.031
response to drugGO:0042493750.031
positive regulation of cell adhesionGO:0045785800.031
cellular response to inorganic substanceGO:0071241370.031
l ascorbic acid metabolic processGO:001985240.030
monocarboxylic acid metabolic processGO:00327871910.030
Human Worm
extracellular matrix organizationGO:00301981470.030
cytokine productionGO:00018163190.030
apoptotic signaling pathwayGO:00971903060.030
Human
regulation of membrane potentialGO:00423911920.030
steroid metabolic processGO:00082021190.030
proteasomal protein catabolic processGO:0010498980.029
protein n linked glycosylationGO:0006487120.029
peripheral nervous system axon regenerationGO:001401220.029
regulation of apoptotic signaling pathwayGO:20012331970.029
Human
adult locomotory behaviorGO:0008344910.028
regulation of cell activationGO:00508652890.028
regulation of receptor activityGO:0010469410.028
striated muscle tissue developmentGO:00147062930.028
oxidation reduction processGO:00551143420.028
Human Yeast Worm
regulation of kinase activityGO:00435492490.027
locomotory behaviorGO:00076261950.027
regulation of cytokine productionGO:00018172660.027
regulation of defense responseGO:00313472330.027
bone developmentGO:00603481200.027
protein stabilizationGO:0050821250.027
cellular protein complex assemblyGO:00436231160.026
nucleotide catabolic processGO:00091662170.026
glycosylationGO:0070085620.026
cholesterol metabolic processGO:0008203560.025
regulation of ion transmembrane transportGO:00347651190.025
t cell activationGO:00421102890.025
regulation of cellular amine metabolic processGO:0033238200.025
organonitrogen compound catabolic processGO:19015652640.025
regulation of cell morphogenesis involved in differentiationGO:00107691510.025
cellular response to molecule of bacterial originGO:0071219830.025
amine metabolic processGO:0009308450.024
cardiac muscle cell differentiationGO:0055007690.024
chaperone mediated protein foldingGO:0061077100.024
lateral inhibitionGO:004633110.024
protein modification by small protein conjugationGO:00324461870.024
macromolecule catabolic processGO:00090572810.023
golgi vesicle transportGO:0048193300.023
glycosyl compound metabolic processGO:19016572460.023
regulation of secretion by cellGO:19035302490.023
nucleoside triphosphate catabolic processGO:00091432050.023
positive regulation of necrotic cell deathGO:001094010.023
muscle cell differentiationGO:00426922610.023
regulation of secretionGO:00510462740.023
intracellular protein transportGO:00068862040.023
ossificationGO:00015032160.022
positive regulation of secretionGO:00510471300.022
t cell differentiationGO:00302171740.022
neuron deathGO:00709971540.022
positive regulation of cell motilityGO:20001471160.022
regulation of cellular catabolic processGO:00313292420.022
second messenger mediated signalingGO:0019932730.022
cellular ion homeostasisGO:00068731650.022
cellular chemical homeostasisGO:00550822150.022
peptidyl proline hydroxylationGO:001951130.022
Human Worm
negative regulation of interleukin 2 productionGO:003270380.022
cognitionGO:00508901490.021
lipid localizationGO:00108761260.021
organonitrogen compound biosynthetic processGO:19015661920.021
cellular response to lipidGO:00713961450.021
retina homeostasisGO:0001895230.021
maintenance of locationGO:0051235890.021
divalent inorganic cation homeostasisGO:00725071380.021
protein ubiquitinationGO:00165671710.021
cell growthGO:00160491300.021
regulation of cell cycleGO:00517262810.020
mitotic cell cycleGO:00002781950.020
cellular response to biotic stimulusGO:0071216920.020
cardiocyte differentiationGO:0035051870.020
positive regulation of apoptotic processGO:00430652170.020
positive regulation of cellular catabolic processGO:00313311480.020
phagocytosisGO:0006909660.020
inorganic cation transmembrane transportGO:00986622070.020
regulation of hydrolase activityGO:00513362460.019
protein targetingGO:00066051430.019
negative regulation of translationGO:0017148220.019
protein maturationGO:00516041760.019
carbohydrate derivative catabolic processGO:19011362310.019
circulatory system processGO:00030131970.019
response to steroid hormoneGO:0048545560.019
cellular response to growth factor stimulusGO:00713631970.019
purine nucleotide metabolic processGO:00061633020.018
respiratory system developmentGO:00605411900.018
retrograde vesicle mediated transport golgi to erGO:000689010.018
reactive oxygen species metabolic processGO:0072593840.018
chromatin organizationGO:00063252060.018
organic acid biosynthetic processGO:0016053860.018
positive regulation of secretion by cellGO:19035321140.018
inflammatory responseGO:00069542440.018
regulation of cell projection organizationGO:00313442060.018
nuclear transportGO:00511691390.018
purine containing compound catabolic processGO:00725232130.018
substantia nigra developmentGO:002176220.018
cellular response to hormone stimulusGO:00328701500.018
hepaticobiliary system developmentGO:0061008670.018
inclusion body assemblyGO:007084130.018
carbohydrate metabolic processGO:00059752300.018
ribose phosphate metabolic processGO:00196932910.017
regulation of cell motilityGO:20001452360.017
ribonucleoside triphosphate metabolic processGO:00091992200.017
cellular metal ion homeostasisGO:00068751510.017
positive regulation of cellular amino acid metabolic processGO:004576430.017
antigen processing and presentationGO:0019882470.017
nucleocytoplasmic transportGO:00069131390.017
negative regulation of molecular functionGO:00440922580.017
regulation of tube sizeGO:0035150570.017
regulation of establishment of protein localizationGO:00702011810.017
regulation of protein kinase activityGO:00458592320.017
germ cell developmentGO:00072811850.017
Mouse
peptidyl amino acid modificationGO:00181933360.017
Human Worm
localization within membraneGO:005166840.017
positive regulation of defense responseGO:00313491240.017
cell recognitionGO:0008037830.017
ribonucleoside monophosphate metabolic processGO:0009161800.016
regulation of mapk cascadeGO:00434082480.016
substrate adhesion dependent cell spreadingGO:0034446300.016
negative regulation of neuron projection developmentGO:0010977500.016
regulation of proteolysis involved in cellular protein catabolic processGO:1903050560.016
protein modification by small protein conjugation or removalGO:00706472070.016
purine nucleoside triphosphate catabolic processGO:00091462030.016
heart morphogenesisGO:00030071780.016
cytokinetic processGO:003250620.016
cellular nitrogen compound catabolic processGO:00442702800.016
carboxylic acid biosynthetic processGO:0046394860.016
regulation of t cell activationGO:00508631700.016
protein secretionGO:00093061110.016
response to radiationGO:00093141650.016
cellular lipid metabolic processGO:00442553230.016
intrinsic apoptotic signaling pathwayGO:00971931320.016
Human
small molecule biosynthetic processGO:00442831320.016
multicellular organism growthGO:00352641610.016
regulation of metal ion transportGO:00109591060.016
response to molecule of bacterial originGO:00022371430.016
cargo loading into vesicleGO:003545930.016
positive regulation of cell cycleGO:0045787920.016
negative regulation of intrinsic apoptotic signaling pathwayGO:2001243340.016
inter male aggressive behaviorGO:000212130.016
regulation of neuron projection developmentGO:00109751690.016
modification dependent protein catabolic processGO:00199411330.016
cellular macromolecule catabolic processGO:00442652060.015
midgut developmentGO:000749440.015
regulation of ion transportGO:00432692150.015
protein localization to membraneGO:00726571080.015
cellular ketone metabolic processGO:0042180840.015
nucleotide biosynthetic processGO:0009165780.015
nucleoside catabolic processGO:00091642060.015
neuron projection guidanceGO:00974851410.015
immune effector processGO:00022523210.015
regulation of reactive oxygen species metabolic processGO:2000377400.015
mesenchyme developmentGO:00604851520.015
er associated ubiquitin dependent protein catabolic processGO:0030433100.015
meiotic nuclear divisionGO:00071261150.015
innate immune responseGO:00450871570.015
purine nucleotide catabolic processGO:00061952110.015
nucleoside phosphate catabolic processGO:19012922220.015
leukocyte migrationGO:00509001240.015
cell agingGO:0007569350.015
renal system developmentGO:00720012250.015
adult behaviorGO:00305341350.015
heterocycle catabolic processGO:00467002800.015
positive regulation of cytokine productionGO:00018191740.015
negative regulation of neuron deathGO:1901215980.015
calcineurin nfat signaling cascadeGO:003317380.015
liver developmentGO:0001889660.015
positive regulation of growthGO:00459271040.015
modification dependent macromolecule catabolic processGO:00436321330.015
transmembrane receptor protein serine threonine kinase signaling pathwayGO:00071781940.014
cellular protein catabolic processGO:00442571550.014
cellular response to lipopolysaccharideGO:0071222770.014
action potentialGO:0001508780.014
regulation of lymphocyte differentiationGO:00456191070.014
neuronal action potentialGO:0019228540.014
hexose metabolic processGO:0019318980.014
regulation of cell substrate adhesionGO:0010810730.014
cellular response to antibioticGO:007123640.014
positive regulation of protein modification processGO:00314012990.014
regulation of body fluid levelsGO:00508781620.014
positive regulation of innate immune responseGO:0045089800.014
positive regulation of cell substrate adhesionGO:0010811470.014
negative regulation of protein modification processGO:00314001630.014
purine nucleoside metabolic processGO:00422782410.014
organic cyclic compound catabolic processGO:19013612950.014
glycosyl compound catabolic processGO:19016582060.014
multicellular organismal signalingGO:0035637910.014
response to estrogenGO:0043627240.014
purine ribonucleoside triphosphate catabolic processGO:00092071990.014
alcohol metabolic processGO:00060661160.014
mapk cascadeGO:00001652810.013
stem cell differentiationGO:00488632680.013
forebrain developmentGO:00309003020.013
nucleotide sugar metabolic processGO:000922540.013
cellular calcium ion homeostasisGO:00068741190.013
cell chemotaxisGO:0060326810.013
regulation of leukocyte proliferationGO:00706631210.013
ribonucleoside catabolic processGO:00424542060.013
establishment of protein localization to membraneGO:0090150540.013
epithalamus developmentGO:002153820.013
positive regulation of reactive oxygen species metabolic processGO:2000379110.013
blood vessel morphogenesisGO:00485142850.013
triglyceride metabolic processGO:0006641510.013
lymphocyte differentiationGO:00300982420.013
cellular component assembly involved in morphogenesisGO:00109271390.013
positive regulation of viral entry into host cellGO:004659830.013
positive regulation of apoptotic cell clearanceGO:200042730.013
purine containing compound biosynthetic processGO:0072522700.013
nuclear divisionGO:00002801580.013
nucleoside metabolic processGO:00091162460.013
placenta developmentGO:00018901400.013
vascular process in circulatory systemGO:0003018620.013
cellular transition metal ion homeostasisGO:0046916320.013
response to lipopolysaccharideGO:00324961280.013
leukocyte differentiationGO:00025213420.013
positive regulation of neuron projection developmentGO:0010976790.013
g protein coupled receptor signaling pathwayGO:00071862430.013
regulation of reactive oxygen species biosynthetic processGO:190342620.013
receptor mediated endocytosisGO:0006898510.013
neural tube developmentGO:00219151600.013
negative regulation of intracellular signal transductionGO:19025321670.013
lipoprotein metabolic processGO:0042157430.013
feeding behaviorGO:0007631620.013
b cell activationGO:00421131610.013
organophosphate catabolic processGO:00464342320.013
ameboidal type cell migrationGO:00016671280.013
regulation of lymphocyte activationGO:00512492400.013
glucose metabolic processGO:0006006920.013
cell divisionGO:00513011200.013
regulation of protein oligomerizationGO:003245940.013
antigen processing and presentation of peptide antigen via mhc class iGO:000247490.013
urogenital system developmentGO:00016552610.013
regulation of neuron deathGO:19012141340.012
blastocyst developmentGO:0001824800.012
purine ribonucleoside monophosphate metabolic processGO:0009167800.012
response to temperature stimulusGO:0009266550.012
ribonucleotide metabolic processGO:00092592910.012
homotypic cell cell adhesionGO:0034109280.012
leukocyte chemotaxisGO:0030595690.012
ribonucleotide catabolic processGO:00092612080.012
neuron apoptotic processGO:00514021420.012
connective tissue developmentGO:00614481790.012
dendritic cell chemotaxisGO:000240770.012
positive regulation of protein catabolic processGO:0045732600.012
sensory perceptionGO:00076002450.012
cellular divalent inorganic cation homeostasisGO:00725031270.012
spermatid differentiationGO:00485151150.012
Mouse
negative regulation of phagocytosisGO:005076540.012
positive regulation of apoptotic signaling pathwayGO:2001235950.012
beta amyloid clearanceGO:009724220.012
mitotic cytokinesisGO:000028140.012
regulation of calcium mediated signalingGO:0050848190.012
lipid transportGO:0006869980.012
purine nucleoside catabolic processGO:00061522050.012
regulation of mitotic cell cycleGO:00073461260.012
canonical wnt signaling pathwayGO:00600701300.012
cellular response to external stimulusGO:0071496880.012
regulation of cell cycle phase transitionGO:1901987770.012
nucleoside monophosphate metabolic processGO:0009123850.012
purine nucleoside monophosphate metabolic processGO:0009126810.012
transition metal ion homeostasisGO:0055076540.012
purine ribonucleotide metabolic processGO:00091502900.012
mesenchymal cell differentiationGO:00487621070.012
positive regulation of cell projection organizationGO:0031346950.012
establishment of protein localization to organelleGO:00725941180.012
transmission of nerve impulseGO:0019226760.012
regulation of neuron apoptotic processGO:00435231220.012
regulation of response to woundingGO:19030341890.012
cellular modified amino acid metabolic processGO:0006575630.012
Human Worm
spermatid developmentGO:00072861080.012
Mouse
diencephalon developmentGO:0021536630.012
aromatic compound catabolic processGO:00194392860.012
er to golgi vesicle mediated transportGO:0006888110.012
carboxylic acid catabolic processGO:0046395510.012
wnt signaling pathwayGO:00160551880.012
positive regulation of lymphocyte activationGO:00512511400.012
interspecies interaction between organismsGO:0044419830.012
negative regulation of oxidative stress induced cell deathGO:190320290.011
striated muscle cell developmentGO:00550021250.011
wound healingGO:00420601570.011
regulation of organelle organizationGO:00330432890.011
positive regulation of cell activationGO:00508671580.011
calcium mediated signalingGO:0019722460.011
regulation of transferase activityGO:00513382630.011
positive regulation of hydrolase activityGO:00513451480.011
divalent inorganic cation transportGO:00725111780.011
compound eye developmentGO:004874910.011
regulation of chemotaxisGO:0050920530.011
molting cycleGO:0042303900.011
muscle contractionGO:00069361010.011
immune response regulating signaling pathwayGO:00027641250.011
mitotic cell cycle processGO:19030471590.011
regulation of purine nucleotide metabolic processGO:19005421690.011
organ regenerationGO:003110020.011
cell junction assemblyGO:0034329520.011
mrna processingGO:0006397630.011
carbohydrate homeostasisGO:00335001280.011
purine ribonucleoside metabolic processGO:00461282410.011
regulation of peptidyl tyrosine phosphorylationGO:0050730930.011
purine ribonucleoside biosynthetic processGO:0046129190.011
hexose catabolic processGO:001932030.011
fertilizationGO:00095661270.011
regulation of beta amyloid clearanceGO:190022110.011
positive regulation of cell migrationGO:00303351090.011
glucose homeostasisGO:00425931280.011
response to epidermal growth factorGO:007084940.011
regulation of cholesterol metabolic processGO:0090181140.011
negative regulation of response to oxidative stressGO:1902883100.011
negative regulation of immune system processGO:00026832090.011
lung developmentGO:00303241640.011
retinoic acid receptor signaling pathwayGO:0048384170.011
adaptive immune response based on somatic recombination of immune receptors built from immunoglobulin superfamily domainsGO:00024601450.011
adaptive immune responseGO:00022501550.011
negative regulation of cholesterol transportGO:003237540.010
translesion synthesisGO:001998510.010
sterol metabolic processGO:0016125580.010
lymphocyte activation involved in immune responseGO:0002285930.010
negative regulation of lymphocyte activationGO:0051250910.010
learning or memoryGO:00076111480.010
regulation of proteolysisGO:00301621640.010
mrna metabolic processGO:0016071840.010
regulation of protein catabolic processGO:00421761080.010
nucleoside phosphate biosynthetic processGO:1901293790.010
copper ion transportGO:0006825100.010
skin developmentGO:00435882200.010
entry into other organism involved in symbiotic interactionGO:0051828150.010
cell type specific apoptotic processGO:00972852680.010
organelle fissionGO:00482851700.010
developmental maturationGO:00217001930.010
regulation of hormone levelsGO:00108172110.010
small molecule catabolic processGO:0044282710.010
meiotic cell cycleGO:00513211220.010
regulation of calcineurin nfat signaling cascadeGO:007088450.010
monosaccharide metabolic processGO:00059961060.010
interferon gamma productionGO:0032609670.010
negative regulation of leukocyte proliferationGO:0070664460.010
reactive nitrogen species metabolic processGO:200105700.010
regulation of substrate adhesion dependent cell spreadingGO:1900024120.010
peptidyl tyrosine phosphorylationGO:00181081430.010
coagulationGO:0050817780.010
peptidyl asparagine modificationGO:001819610.010
regulation of cellular protein catabolic processGO:1903362610.010

P4hb disease predictions

Disease predictions are made from cross-annotation of human disease genes to the identified functional analogs in mouse and predicted with the mouse functional network.

DiseaseDO term IDSizeProbabilityFunc Analog Org
connective tissue diseaseDOID:6500.103
disease of anatomical entityDOID:700.103
musculoskeletal system diseaseDOID:1700.103
bone development diseaseDOID:008000600.103
osteochondrodysplasiaDOID:225600.103
bone diseaseDOID:008000100.103
nervous system diseaseDOID:86300.044
cancerDOID:16200.037
disease of cellular proliferationDOID:1456600.037
organ system cancerDOID:005068600.034
inherited metabolic disorderDOID:65500.032
disease of metabolismDOID:001466700.032
immune system cancerDOID:006008300.024
hematologic cancerDOID:253100.023
central nervous system diseaseDOID:33100.021
bone marrow cancerDOID:496000.015
sensory system diseaseDOID:005015500.015
muscular diseaseDOID:008000000.012
muscle tissue diseaseDOID:6600.012
myopathyDOID:42300.012
brain diseaseDOID:93600.010