IMP: Integrative Multi-species Prediction

Mus musculus

84 known processes

Tlx2

T-cell leukemia, homeobox 2

(Aliases: NCX,Tlx1l2,Tlx1l1,Enx,Hox11l1,Hox11L.1,Ncx1)

Ensembl: ENSMUSG00000068327
Entrez: 21909
UniProtKB: Q61663

Process Predictions
Disease Predictions

Tlx2 biological process predictions

Show only novel predictionsHighlight processes of functional analogs

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Biological process	GO term ID	Process size	Probability	Func Analog Org
forebrain development	GO:0030900	302	0.860
respiratory system development	GO:0060541	190	0.778
gland development	GO:0048732	330	0.765
cell fate specification	GO:0001708	72	0.759	Mouse
neuron fate specification	GO:0048665	30	0.747	Mouse
regionalization	GO:0003002	337	0.735
skeletal system development	GO:0001501	356	0.691
regulation of neuron differentiation	GO:0045664	281	0.687
developmental maturation	GO:0021700	193	0.686
epithelial tube morphogenesis	GO:0060562	303	0.682
respiratory tube development	GO:0030323	167	0.669
negative regulation of cell proliferation	GO:0008285	296	0.665
bmp signaling pathway	GO:0030509	93	0.639
stem cell differentiation	GO:0048863	268	0.633
cell fate commitment	GO:0045165	210	0.625	Mouse
epidermis development	GO:0008544	187	0.620
axonogenesis	GO:0007409	274	0.614
telencephalon development	GO:0021537	186	0.611
appendage development	GO:0048736	166	0.601	Fly
endocrine system development	GO:0035270	98	0.600
branching morphogenesis of an epithelial tube	GO:0048754	159	0.598
embryonic organ morphogenesis	GO:0048562	276	0.593
muscle tissue development	GO:0060537	308	0.577
neuron migration	GO:0001764	122	0.559	Mouse
embryonic skeletal system development	GO:0048706	120	0.557
lung development	GO:0030324	164	0.547
ear morphogenesis	GO:0042471	118	0.530
cerebral cortex development	GO:0021987	86	0.519
axon guidance	GO:0007411	141	0.499
central nervous system neuron differentiation	GO:0021953	162	0.486
germ cell development	GO:0007281	185	0.486
multicellular organismal signaling	GO:0035637	91	0.481
ear development	GO:0043583	200	0.476
stem cell development	GO:0048864	219	0.471
urogenital system development	GO:0001655	261	0.447
positive regulation of nervous system development	GO:0051962	221	0.433
cell maturation	GO:0048469	127	0.427
heart morphogenesis	GO:0003007	178	0.417
mesenchyme development	GO:0060485	152	0.416
hindbrain development	GO:0030902	128	0.412
pancreatic pp cell fate commitment	GO:0003329	2	0.404
cellular amino acid metabolic process	GO:0006520	103	0.392
blood vessel morphogenesis	GO:0048514	285	0.386
stem cell maintenance	GO:0019827	130	0.384
stem cell proliferation	GO:0072089	117	0.376
spinal cord development	GO:0021510	81	0.367
kidney development	GO:0001822	213	0.364
ventral spinal cord interneuron fate commitment	GO:0060579	14	0.363
sensory perception	GO:0007600	245	0.355
striated muscle tissue development	GO:0014706	293	0.349
neuron projection guidance	GO:0097485	141	0.348
regulation of cellular amino acid metabolic process	GO:0006521	5	0.341
regulation of organ morphogenesis	GO:2000027	144	0.341
paraxial mesodermal cell differentiation	GO:0048342	2	0.340
appendage morphogenesis	GO:0035107	149	0.339	Fly
morphogenesis of a branching structure	GO:0001763	203	0.325
myeloid cell differentiation	GO:0030099	233	0.317
pituitary gland development	GO:0021983	38	0.311
neural precursor cell proliferation	GO:0061351	121	0.309
neural tube development	GO:0021915	160	0.308
cellular amine metabolic process	GO:0044106	44	0.294
autonomic nervous system development	GO:0048483	43	0.288
ventral spinal cord development	GO:0021517	48	0.288
neuromuscular process	GO:0050905	99	0.286
renal tubule development	GO:0061326	87	0.286
positive regulation of transcription via serum response element binding	GO:0010735	1	0.285
positive regulation of cell development	GO:0010720	237	0.282
somatotropin secreting cell differentiation	GO:0060126	4	0.281
spinal cord oligodendrocyte cell fate specification	GO:0021530	3	0.280
skeletal muscle organ development	GO:0060538	163	0.280
fat cell differentiation	GO:0045444	160	0.276
tube formation	GO:0035148	140	0.266
skeletal system morphogenesis	GO:0048705	203	0.260
neurohypophysis development	GO:0021985	2	0.257
skin development	GO:0043588	220	0.257
mesenchymal cell differentiation	GO:0048762	107	0.257
kidney epithelium development	GO:0072073	121	0.255
morphogenesis of a branching epithelium	GO:0061138	193	0.252
regulation of cell cycle	GO:0051726	281	0.251	Fly
lung cell differentiation	GO:0060479	30	0.242
ameboidal type cell migration	GO:0001667	128	0.239
regulation of vasculature development	GO:1901342	88	0.239
developmental induction	GO:0031128	34	0.238
cell cell signaling involved in cell fate commitment	GO:0045168	35	0.233
digestive tract development	GO:0048565	190	0.229
cardiac chamber morphogenesis	GO:0003206	93	0.228
carbon catabolite repression of transcription from rna polymerase ii promoter	GO:0000437	1	0.225
epithelial cell development	GO:0002064	159	0.223
regulation of cellular ketone metabolic process	GO:0010565	66	0.220
mesoderm development	GO:0007498	100	0.214
positive regulation of programmed cell death	GO:0043068	218	0.213
ventral spinal cord interneuron differentiation	GO:0021514	16	0.212
cardiac pacemaker cell fate commitment	GO:0060927	1	0.212
nephron morphogenesis	GO:0072028	69	0.212
thyroid stimulating hormone secreting cell differentiation	GO:0060129	4	0.211
nephron epithelium development	GO:0072009	92	0.209
epithelial tube formation	GO:0072175	130	0.206
regulation of cell migration	GO:0030334	219	0.205
connective tissue development	GO:0061448	179	0.203
limbic system development	GO:0021761	72	0.201
pallium development	GO:0021543	120	0.200
embryonic epithelial tube formation	GO:0001838	130	0.200
wnt signaling pathway	GO:0016055	188	0.197
mesonephric epithelium development	GO:0072163	94	0.195
transmembrane receptor protein serine threonine kinase signaling pathway	GO:0007178	194	0.192
digestive system development	GO:0055123	200	0.191
regulation of organ growth	GO:0046620	61	0.190
hair follicle development	GO:0001942	85	0.190
hypophysis morphogenesis	GO:0048850	3	0.189
ectoderm formation	GO:0001705	3	0.188
regulation of cell morphogenesis involved in differentiation	GO:0010769	151	0.186
determination of left right symmetry	GO:0007368	80	0.186
kidney morphogenesis	GO:0060993	83	0.185
formation of primary germ layer	GO:0001704	77	0.184
positive regulation of glial cell differentiation	GO:0045687	21	0.183
epithelial cell proliferation	GO:0050673	174	0.181
cell fate determination involved in pattern specification	GO:0060582	1	0.181
forebrain cell migration	GO:0021885	58	0.180
regulation of cardioblast differentiation	GO:0051890	3	0.178
carbohydrate derivative biosynthetic process	GO:1901137	183	0.178
neural tube formation	GO:0001841	108	0.178
cartilage development	GO:0051216	140	0.175
nephron development	GO:0072006	109	0.175
chemotaxis	GO:0006935	247	0.172
leukocyte differentiation	GO:0002521	342	0.172
glandular epithelial cell differentiation	GO:0002067	38	0.171
ureteric bud morphogenesis	GO:0060675	62	0.170
leukocyte proliferation	GO:0070661	172	0.170
action potential	GO:0001508	78	0.169
regulation of stem cell proliferation	GO:0072091	78	0.168
mesoderm formation	GO:0001707	62	0.167
regulation of secretion by cell	GO:1903530	249	0.167
inner ear morphogenesis	GO:0042472	101	0.167
regulation of ion transport	GO:0043269	215	0.165
paraxial mesodermal cell fate commitment	GO:0048343	2	0.165
cellular ketone metabolic process	GO:0042180	84	0.164
positive regulation of gliogenesis	GO:0014015	27	0.164
purkinje myocyte differentiation	GO:0003168	1	0.164
morphogenesis of embryonic epithelium	GO:0016331	159	0.163
cell differentiation in spinal cord	GO:0021515	53	0.163
lung epithelium development	GO:0060428	37	0.162
development of primary sexual characteristics	GO:0045137	143	0.160
plasma cell differentiation	GO:0002317	3	0.157
primary neural tube formation	GO:0014020	95	0.157
sensory organ morphogenesis	GO:0090596	242	0.156
hippocampus development	GO:0021766	52	0.156
regulation of metal ion transport	GO:0010959	106	0.155
molting cycle	GO:0042303	90	0.153
negative regulation of nervous system development	GO:0051961	156	0.152
determination of heart left right asymmetry	GO:0061371	48	0.151
striated muscle cell proliferation	GO:0014855	39	0.149
skeletal muscle cell differentiation	GO:0035914	66	0.147
limb morphogenesis	GO:0035108	149	0.147
amine metabolic process	GO:0009308	45	0.147
embryonic heart tube development	GO:0035050	65	0.147
nephron tubule morphogenesis	GO:0072078	68	0.147
digestive tract morphogenesis	GO:0048546	147	0.146
ureteric bud development	GO:0001657	94	0.146
sensory perception of sound	GO:0007605	97	0.146
ventral spinal cord interneuron fate determination	GO:0060580	1	0.142
oogenesis	GO:0048477	56	0.142
nitrogen compound transport	GO:0071705	271	0.141
atrioventricular node cell development	GO:0060928	2	0.141
limb development	GO:0060173	166	0.140
cytoplasmic transport	GO:0016482	234	0.140
cell type specific apoptotic process	GO:0097285	268	0.140
axon ensheathment	GO:0008366	76	0.139
regulation of fat cell differentiation	GO:0045598	81	0.139
positive regulation of cardioblast differentiation	GO:0051891	3	0.138
lung epithelial cell differentiation	GO:0060487	29	0.137
atrioventricular node cell differentiation	GO:0060922	2	0.137
spinal cord oligodendrocyte cell differentiation	GO:0021529	3	0.135
b cell differentiation	GO:0030183	78	0.135
cation transport	GO:0006812	399	0.134
carbon catabolite activation of transcription from rna polymerase ii promoter	GO:0000436	4	0.133
renal tubule morphogenesis	GO:0061333	72	0.132
transmembrane receptor protein tyrosine kinase signaling pathway	GO:0007169	247	0.130
auditory receptor cell fate determination	GO:0042668	3	0.129
ventricular cardiac muscle tissue morphogenesis	GO:0055010	32	0.129
positive regulation of epithelial cell proliferation	GO:0050679	68	0.128
cardiac ventricle development	GO:0003231	83	0.128
negative regulation of wnt signaling pathway	GO:0030178	73	0.128
cardiac muscle tissue development	GO:0048738	130	0.126
inner ear receptor cell differentiation	GO:0060113	61	0.126
auditory receptor cell fate specification	GO:0042667	1	0.126
embryonic heart tube morphogenesis	GO:0003143	51	0.125
embryonic limb morphogenesis	GO:0030326	126	0.125
regulation of body fluid levels	GO:0050878	162	0.123
regulation of canonical wnt signaling pathway	GO:0060828	82	0.123
hair cell differentiation	GO:0035315	40	0.123
divalent inorganic cation transport	GO:0072511	178	0.122
forebrain neuron differentiation	GO:0021879	52	0.122
subpallium neuron fate commitment	GO:0060163	2	0.121
t cell activation	GO:0042110	289	0.121
regulation of glial cell differentiation	GO:0045685	41	0.121
pancreatic a cell fate commitment	GO:0003326	2	0.120
mesoderm morphogenesis	GO:0048332	64	0.120
purine containing compound metabolic process	GO:0072521	311	0.120
pancreatic pp cell differentiation	GO:0003312	2	0.119
oligodendrocyte differentiation	GO:0048709	53	0.118
regulation of neuron projection development	GO:0010975	169	0.118
mesodermal cell differentiation	GO:0048333	22	0.117
neuron fate determination	GO:0048664	9	0.117
atrial cardiac muscle cell development	GO:0055014	2	0.117
translation	GO:0006412	93	0.116
glial cell differentiation	GO:0010001	131	0.116
segmentation	GO:0035282	93	0.115
protein localization to nucleus	GO:0034504	121	0.113
outflow tract morphogenesis	GO:0003151	53	0.112
mesonephric tubule development	GO:0072164	94	0.112
carbohydrate metabolic process	GO:0005975	230	0.112
placenta development	GO:0001890	140	0.111
cerebral cortex cell migration	GO:0021795	44	0.109
regulation of cell motility	GO:2000145	236	0.109
camera type eye development	GO:0043010	266	0.108
positive regulation of cellular amino acid metabolic process	GO:0045764	3	0.108
regulation of gliogenesis	GO:0014013	50	0.107
immune effector process	GO:0002252	321	0.106
globus pallidus development	GO:0021759	2	0.106
menarche	GO:0042696	1	0.106
notch signaling pathway	GO:0007219	71	0.105	Fly
regulation of myeloid cell differentiation	GO:0045637	96	0.104
glial cell fate commitment	GO:0021781	14	0.104
hair cycle	GO:0042633	90	0.103
mechanoreceptor differentiation	GO:0042490	67	0.103
male gamete generation	GO:0048232	285	0.102
locomotory behavior	GO:0007626	195	0.102
nephron tubule development	GO:0072080	84	0.102
regulation of anagen	GO:0051884	1	0.102
metal ion homeostasis	GO:0055065	189	0.101
cardiac neural crest cell migration involved in outflow tract morphogenesis	GO:0003253	3	0.101
neural crest cell development	GO:0014032	48	0.101
mesenchymal cell development	GO:0014031	93	0.100
epithalamus development	GO:0021538	2	0.100
divalent metal ion transport	GO:0070838	172	0.100
spermatogenesis	GO:0007283	284	0.099
adenohypophysis development	GO:0021984	14	0.099
myeloid cell homeostasis	GO:0002262	114	0.099
regulation of kidney development	GO:0090183	40	0.099
auditory receptor cell differentiation	GO:0042491	37	0.099
response to growth factor	GO:0070848	198	0.099
regulation of wnt signaling pathway	GO:0030111	123	0.098
muscle cell differentiation	GO:0042692	261	0.097
atrioventricular node cell fate commitment	GO:0060929	1	0.097
regulation of auditory receptor cell differentiation	GO:0045607	4	0.097
regulation of bmp signaling pathway	GO:0030510	60	0.097
midbrain development	GO:0030901	35	0.097
erythrocyte differentiation	GO:0030218	88	0.096
neuroblast proliferation	GO:0007405	49	0.096
lymphocyte differentiation	GO:0030098	242	0.096
gastrulation	GO:0007369	116	0.095
regulation of muscle tissue development	GO:1901861	97	0.095
atrial cardiac muscle cell differentiation	GO:0055011	2	0.095
angiogenesis	GO:0001525	201	0.095
metanephros development	GO:0001656	79	0.095
spinal cord dorsal ventral patterning	GO:0021513	23	0.094
cation homeostasis	GO:0055080	212	0.093
sensory system development	GO:0048880	3	0.093
membrane organization	GO:0061024	245	0.092
spinal cord patterning	GO:0021511	25	0.092
regulation of cardiac muscle cell proliferation	GO:0060043	23	0.091
metanephric macula densa development	GO:0072227	1	0.090
tube closure	GO:0060606	91	0.090
regulation of stem cell differentiation	GO:2000736	50	0.090
positive regulation of endocardial cushion to mesenchymal transition involved in heart valve formation	GO:2000802	1	0.090
blastocyst development	GO:0001824	80	0.090
cranial nerve development	GO:0021545	41	0.090
wound healing	GO:0042060	157	0.089
cell fate commitment involved in pattern specification	GO:0060581	14	0.089
cell differentiation in hindbrain	GO:0021533	24	0.089
male gonad development	GO:0008584	88	0.088
muscle cell development	GO:0055001	133	0.088
regulation of secretion	GO:0051046	274	0.088
ossification	GO:0001503	216	0.087
rhythmic process	GO:0048511	174	0.087
peptidyl amino acid modification	GO:0018193	336	0.085
developmental programmed cell death	GO:0010623	41	0.085
calcium ion transport	GO:0006816	159	0.085
telencephalon cell migration	GO:0022029	55	0.085
apoptotic process involved in morphogenesis	GO:0060561	25	0.085
cardiocyte differentiation	GO:0035051	87	0.084
embryonic skeletal system morphogenesis	GO:0048704	91	0.084
nucleoside phosphate metabolic process	GO:0006753	338	0.083
canonical wnt signaling pathway	GO:0060070	130	0.083
diencephalon development	GO:0021536	63	0.082
somitogenesis	GO:0001756	69	0.082
establishment of organ orientation	GO:0048561	1	0.082
lung secretory cell differentiation	GO:0061140	13	0.082
anatomical structure homeostasis	GO:0060249	145	0.082
columnar cuboidal epithelial cell differentiation	GO:0002065	82	0.082
myeloid leukocyte differentiation	GO:0002573	119	0.081
neural tube closure	GO:0001843	90	0.081
sensory perception of mechanical stimulus	GO:0050954	107	0.081
muscle system process	GO:0003012	141	0.081
central nervous system vasculogenesis	GO:0022009	3	0.080
regulation of neural precursor cell proliferation	GO:2000177	70	0.080
tissue remodeling	GO:0048771	102	0.080
branching involved in ureteric bud morphogenesis	GO:0001658	56	0.080
neuronal action potential	GO:0019228	54	0.080
motor neuron axon guidance	GO:0008045	26	0.080
compound eye development	GO:0048749	1	0.079
cytosolic calcium ion homeostasis	GO:0051480	70	0.079
regulation of epidermis development	GO:0045682	33	0.078
regulation of retina development in camera type eye	GO:1902866	3	0.078
gliogenesis	GO:0042063	141	0.078
oligodendrocyte development	GO:0014003	20	0.076
retina development in camera type eye	GO:0060041	119	0.076
positive regulation of neuron differentiation	GO:0045666	141	0.076
oocyte development	GO:0048599	33	0.075
neural crest cell differentiation	GO:0014033	54	0.075
positive regulation of rna polymerase ii transcriptional preinitiation complex assembly	GO:0045899	2	0.075
endomembrane system organization	GO:0010256	147	0.074
mammary gland morphogenesis	GO:0060443	54	0.074
cd4 positive alpha beta t cell differentiation	GO:0043367	41	0.074
smoothened signaling pathway	GO:0007224	105	0.074
g protein coupled receptor signaling pathway	GO:0007186	243	0.073
muscle cell proliferation	GO:0033002	52	0.073
ovulation cycle	GO:0042698	59	0.072
positive regulation of stem cell proliferation	GO:2000648	59	0.072
regulation of organ formation	GO:0003156	34	0.072
lung morphogenesis	GO:0060425	50	0.072
brain segmentation	GO:0035284	3	0.071
nephron epithelium morphogenesis	GO:0072088	68	0.071
metanephric dct cell differentiation	GO:0072240	3	0.071
heart formation	GO:0060914	16	0.071
pulmonary myocardium development	GO:0003350	3	0.071
postganglionic parasympathetic nervous system development	GO:0021784	2	0.071
skin morphogenesis	GO:0043589	38	0.071
nucleocytoplasmic transport	GO:0006913	139	0.071
regulation of epithelial cell proliferation	GO:0050678	141	0.071
maintenance of location	GO:0051235	89	0.070
cellular response to growth factor stimulus	GO:0071363	197	0.070
thymus development	GO:0048538	41	0.070
organ growth	GO:0035265	117	0.070
paramesonephric duct development	GO:0061205	3	0.069
cell fate commitment involved in formation of primary germ layer	GO:0060795	26	0.068
kidney mesenchyme development	GO:0072074	14	0.067
positive regulation of voltage gated calcium channel activity	GO:1901387	2	0.067
regulation of transcription involved in cell fate commitment	GO:0060850	15	0.066
artery development	GO:0060840	53	0.066
female gamete generation	GO:0007292	74	0.066
regulation of neural retina development	GO:0061074	3	0.066
secretory columnal luminar epithelial cell differentiation involved in prostate glandular acinus development	GO:0060528	4	0.065
regulation of membrane potential	GO:0042391	192	0.065
development of primary male sexual characteristics	GO:0046546	88	0.065
oocyte differentiation	GO:0009994	35	0.065
sensory organ boundary specification	GO:0008052	1	0.064
type b pancreatic cell fate commitment	GO:0003327	1	0.064
cardiac chamber development	GO:0003205	108	0.064
oocyte maturation	GO:0001556	18	0.064
pyramidal neuron migration	GO:0021852	1	0.064
mesonephric tubule morphogenesis	GO:0072171	63	0.064
positive regulation of mesenchymal cell proliferation	GO:0002053	33	0.064
t cell proliferation	GO:0042098	120	0.064
hindbrain formation	GO:0021576	1	0.063
regulation of apoptotic signaling pathway	GO:2001233	197	0.063
regulation of protein localization	GO:0032880	231	0.063
divalent inorganic cation homeostasis	GO:0072507	138	0.063
neuromuscular process controlling balance	GO:0050885	59	0.063
regulation of adaptive immune response	GO:0002819	90	0.062
developmental growth involved in morphogenesis	GO:0060560	138	0.062	Fly
epidermis morphogenesis	GO:0048730	33	0.062
detection of monosaccharide stimulus	GO:0034287	1	0.062
metanephros morphogenesis	GO:0003338	24	0.061
transmission of nerve impulse	GO:0019226	76	0.061
prostate gland stromal morphogenesis	GO:0060741	2	0.061
neuroblast differentiation	GO:0014016	2	0.061
female sex differentiation	GO:0046660	84	0.060
embryonic appendage morphogenesis	GO:0035113	126	0.060
glycosyl compound catabolic process	GO:1901658	206	0.060
intracellular protein transport	GO:0006886	204	0.060
regulation of morphogenesis of a branching structure	GO:0060688	53	0.060
protein import	GO:0017038	101	0.059
metanephric nephron morphogenesis	GO:0072273	19	0.059
forebrain morphogenesis	GO:0048853	17	0.059
palate development	GO:0060021	76	0.059
nuclear transport	GO:0051169	139	0.058
asymmetric stem cell division	GO:0098722	3	0.058
renal vesicle induction	GO:0072034	3	0.058
male sex differentiation	GO:0046661	109	0.058
protein localization to organelle	GO:0033365	185	0.058
inner cell mass cell fate commitment	GO:0001827	2	0.058
clara cell differentiation	GO:0060486	4	0.057
cardiac septum development	GO:0003279	59	0.057
cell fate determination	GO:0001709	32	0.057
cell differentiation involved in kidney development	GO:0061005	33	0.057
regulation of cellular amine metabolic process	GO:0033238	20	0.056
gonad development	GO:0008406	141	0.056
spinal cord motor neuron differentiation	GO:0021522	35	0.056
myelination	GO:0042552	74	0.056
positive regulation of auditory receptor cell differentiation	GO:0045609	1	0.055
lung field specification	GO:0060424	3	0.055
regulation of rna polymerase ii transcriptional preinitiation complex assembly	GO:0045898	2	0.055
metanephric nephron tubule development	GO:0072234	16	0.055
positive regulation of stem cell differentiation	GO:2000738	23	0.055
multicellular organism growth	GO:0035264	161	0.054
regulation of lymphocyte proliferation	GO:0050670	117	0.054
mesenchyme morphogenesis	GO:0072132	32	0.054
astrocyte fate commitment	GO:0060018	4	0.054
positive regulation of growth	GO:0045927	104	0.054
specification of organ identity	GO:0010092	30	0.054
positive regulation of behavior	GO:0048520	40	0.054
cell division	GO:0051301	120	0.054
embryonic digit morphogenesis	GO:0042733	56	0.054
cellular divalent inorganic cation homeostasis	GO:0072503	127	0.054
endocardial cushion to mesenchymal transition involved in heart valve formation	GO:0003199	4	0.053
regulation of transcription from rna polymerase ii promoter involved in ventral spinal cord interneuron specification	GO:0021913	4	0.053
synapse organization	GO:0050808	125	0.053
hormone secretion	GO:0046879	128	0.053
lymphocyte homeostasis	GO:0002260	64	0.052
ventricular cardiac myofibril assembly	GO:0055005	3	0.052
asymmetric neuroblast division	GO:0055059	1	0.052
olfactory lobe development	GO:0021988	32	0.051
regulation of endocardial cushion to mesenchymal transition involved in heart valve formation	GO:2000800	1	0.051
negative regulation of calcium ion dependent exocytosis	GO:0045955	3	0.051
midbrain hindbrain boundary maturation	GO:0021732	1	0.051
positive regulation of canonical wnt signaling pathway involved in controlling type b pancreatic cell proliferation	GO:2000081	1	0.051
olfactory bulb development	GO:0021772	30	0.051
forebrain generation of neurons	GO:0021872	63	0.051
positive regulation of cell cycle	GO:0045787	92	0.051
regulation of angiogenesis	GO:0045765	81	0.051
lung induction	GO:0060492	3	0.050
renal system development	GO:0072001	225	0.050
dendrite development	GO:0016358	115	0.050
hormone metabolic process	GO:0042445	86	0.049
purine ribonucleotide metabolic process	GO:0009150	290	0.049
regulation of protein transport	GO:0051223	163	0.049
cell proliferation in forebrain	GO:0021846	30	0.049
chondrocyte differentiation	GO:0002062	72	0.049
septum transversum development	GO:0003343	2	0.049
endoderm development	GO:0007492	45	0.048
regulation of system process	GO:0044057	200	0.048	Mouse
epithelial cell fate commitment	GO:0072148	13	0.048
odontogenesis	GO:0042476	78	0.048
brain morphogenesis	GO:0048854	32	0.048
spemann organizer formation	GO:0060061	2	0.048
positive regulation of protein phosphorylation	GO:0001934	242	0.047
bronchiole development	GO:0060435	3	0.047
regulation of cell activation	GO:0050865	289	0.047
renal inner medulla development	GO:0072053	3	0.047
regulation of mesenchymal cell proliferation	GO:0010464	37	0.047
regulation of establishment of protein localization	GO:0070201	181	0.047
glossopharyngeal nerve morphogenesis	GO:0021615	4	0.047
heart growth	GO:0060419	45	0.047
neuroepithelial cell differentiation	GO:0060563	37	0.046
microtubule based process	GO:0007017	236	0.046
cellular homeostasis	GO:0019725	240	0.046
negative regulation of intracellular signal transduction	GO:1902532	167	0.046
cellular metal ion homeostasis	GO:0006875	151	0.046
positive regulation of transcription from rna polymerase ii promoter involved in norepinephrine biosynthetic process	GO:2000763	1	0.045
cerebellum formation	GO:0021588	1	0.045
lens development in camera type eye	GO:0002088	62	0.045
positive regulation of angiogenesis	GO:0045766	46	0.045
positive regulation of cell migration	GO:0030335	109	0.045
heart contraction	GO:0060047	93	0.045
parasympathetic nervous system development	GO:0048486	19	0.045
response to organonitrogen compound	GO:0010243	246	0.044
homeostasis of number of cells	GO:0048872	210	0.044
inner medullary collecting duct development	GO:0072061	2	0.044
cerebral cortex radially oriented cell migration	GO:0021799	31	0.043
sympathetic nervous system development	GO:0048485	22	0.043
positive regulation of transcription initiation from rna polymerase ii promoter	GO:0060261	5	0.043
metencephalon development	GO:0022037	89	0.043
cellular chemical homeostasis	GO:0055082	215	0.043
regulation of organelle organization	GO:0033043	289	0.043
positive regulation of kidney development	GO:0090184	28	0.043
middle ear morphogenesis	GO:0042474	23	0.043
regulation of translation	GO:0006417	71	0.043
rna polymerase ii transcriptional preinitiation complex assembly	GO:0051123	3	0.042
mesonephros development	GO:0001823	97	0.042
regulation of binding	GO:0051098	111	0.042
trachea cartilage morphogenesis	GO:0060535	4	0.042
regulation of transmembrane transport	GO:0034762	128	0.042
spemann organizer formation at the anterior end of the primitive streak	GO:0060064	1	0.042
striated muscle cell development	GO:0055002	125	0.042
metanephric loop of henle development	GO:0072236	4	0.042
endodermal cell fate specification	GO:0001714	4	0.042
positive regulation of oligodendrocyte differentiation	GO:0048714	9	0.042
apoptotic signaling pathway	GO:0097190	306	0.041
ensheathment of neurons	GO:0007272	76	0.041
regulation of ion transmembrane transport	GO:0034765	119	0.041
astrocyte differentiation	GO:0048708	43	0.041
cardiac ventricle morphogenesis	GO:0003208	50	0.041
nerve development	GO:0021675	67	0.041
ras protein signal transduction	GO:0007265	77	0.041
pigmentation	GO:0043473	71	0.040
proprioception	GO:0019230	4	0.040
phenol containing compound metabolic process	GO:0018958	60	0.040
purine nucleoside triphosphate metabolic process	GO:0009144	226	0.040
posttranscriptional regulation of gene expression	GO:0010608	155	0.040
somite development	GO:0061053	81	0.040
b cell activation	GO:0042113	161	0.040
hair follicle morphogenesis	GO:0031069	29	0.040
positive regulation of transcription by glucose	GO:0046016	3	0.040
negative regulation of cellular amino acid metabolic process	GO:0045763	0	0.039
epithelial cell maturation involved in prostate gland development	GO:0060743	4	0.039
ventricular cardiac muscle tissue development	GO:0003229	38	0.039
positive regulation of bmp signaling pathway	GO:0030513	23	0.039

Tlx2 disease predictions

Disease predictions are made from cross-annotation of human disease genes to the identified functional analogs in mouse and predicted with the mouse functional network.

	Disease	DO term ID	Size	Probability	Func Analog Org
	disease of anatomical entity	DOID:7	0	0.039

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