IMP: Integrative Multi-species Prediction

Mus musculus

83 known processes

Notch3

Notch gene homolog 3 (Drosophila)

(Aliases: AW229011)

Entrez: 18131
Ensembl: ENSMUSG00000038146
UniProtKB: Q61982

Process Predictions
Disease Predictions

Notch3 biological process predictions

Show only novel predictionsHighlight processes of functional analogs

Filter by process size:

Biological process	GO term ID	Process size	Probability	Func Analog Org
epithelial tube morphogenesis	GO:0060562	303	0.980	Mouse Fly
regulation of neuron differentiation	GO:0045664	281	0.973
regionalization	GO:0003002	337	0.957	Mouse Fly
kidney development	GO:0001822	213	0.939
renal system development	GO:0072001	225	0.928
axonogenesis	GO:0007409	274	0.853	Zebrafish Mouse Fly
urogenital system development	GO:0001655	261	0.851
skeletal system development	GO:0001501	356	0.841
morphogenesis of a branching structure	GO:0001763	203	0.832	Mouse
appendage morphogenesis	GO:0035107	149	0.821	Mouse Fly
embryonic organ morphogenesis	GO:0048562	276	0.816	Mouse
ossification	GO:0001503	216	0.802	Mouse
skeletal muscle organ development	GO:0060538	163	0.798	Mouse Fly
response to growth factor	GO:0070848	198	0.753
positive regulation of nervous system development	GO:0051962	221	0.749	Mouse
forebrain development	GO:0030900	302	0.747
limb development	GO:0060173	166	0.747	Mouse
stem cell development	GO:0048864	219	0.739	Zebrafish Mouse Fly
cellular ketone metabolic process	GO:0042180	84	0.735
nephron development	GO:0072006	109	0.733
negative regulation of neuron differentiation	GO:0045665	101	0.728
cellular response to growth factor stimulus	GO:0071363	197	0.725
negative regulation of ossification	GO:0030279	49	0.714	Mouse
muscle tissue development	GO:0060537	308	0.704	Mouse Fly
blood vessel morphogenesis	GO:0048514	285	0.701
skeletal system morphogenesis	GO:0048705	203	0.698
central nervous system neuron differentiation	GO:0021953	162	0.681
stem cell differentiation	GO:0048863	268	0.675	Zebrafish Mouse Fly
regulation of cell adhesion	GO:0030155	154	0.650
lung development	GO:0030324	164	0.646	Mouse
neuron projection guidance	GO:0097485	141	0.646	Fly
connective tissue development	GO:0061448	179	0.632	Mouse
positive regulation of cell development	GO:0010720	237	0.622	Mouse
cell adhesion	GO:0007155	329	0.602	Fly
neural tube development	GO:0021915	160	0.587	Mouse
hindbrain development	GO:0030902	128	0.567	Zebrafish
regulation of cell morphogenesis involved in differentiation	GO:0010769	151	0.566	Mouse
somite development	GO:0061053	81	0.561	Mouse
branching morphogenesis of an epithelial tube	GO:0048754	159	0.554	Mouse
renal tubule development	GO:0061326	87	0.547	Mouse Fly
respiratory system development	GO:0060541	190	0.541	Mouse Fly
kidney epithelium development	GO:0072073	121	0.526	Mouse
regulation of cellular amino acid metabolic process	GO:0006521	5	0.509
positive regulation of cell migration	GO:0030335	109	0.509	Mouse
skin development	GO:0043588	220	0.505	Mouse
neural tube formation	GO:0001841	108	0.499
endoderm development	GO:0007492	45	0.491	Mouse
regulation of wnt signaling pathway	GO:0030111	123	0.489	Mouse
chondrocyte differentiation	GO:0002062	72	0.483
mesonephric tubule development	GO:0072164	94	0.477
cerebral cortex development	GO:0021987	86	0.472
primary neural tube formation	GO:0014020	95	0.466
regulation of cellular ketone metabolic process	GO:0010565	66	0.465
regulation of cellular amine metabolic process	GO:0033238	20	0.460
stem cell proliferation	GO:0072089	117	0.458
regulation of neuron projection development	GO:0010975	169	0.455
cardiac muscle tissue development	GO:0048738	130	0.453	Mouse
gland development	GO:0048732	330	0.452	Zebrafish Mouse Fly
artery development	GO:0060840	53	0.451	Mouse
heart valve development	GO:0003170	23	0.447	Mouse
embryonic skeletal system development	GO:0048706	120	0.441
embryonic skeletal system morphogenesis	GO:0048704	91	0.439
cellular amino acid metabolic process	GO:0006520	103	0.420
renal tubule morphogenesis	GO:0061333	72	0.419	Fly
neural tube closure	GO:0001843	90	0.417
regulation of ossification	GO:0030278	112	0.416	Mouse
wnt signaling pathway	GO:0016055	188	0.413	Mouse
embryonic heart tube morphogenesis	GO:0003143	51	0.408	Mouse
cartilage development	GO:0051216	140	0.408
pallium development	GO:0021543	120	0.404
notch signaling pathway	GO:0007219	71	0.400
cell fate commitment	GO:0045165	210	0.399
arterial endothelial cell differentiation	GO:0060842	5	0.399	Mouse
stem cell maintenance	GO:0019827	130	0.395	Zebrafish Fly
respiratory tube development	GO:0030323	167	0.377	Mouse
cardiocyte differentiation	GO:0035051	87	0.373	Mouse Fly
single organism cell adhesion	GO:0098602	156	0.372
morphogenesis of a branching epithelium	GO:0061138	193	0.369	Mouse
angiogenesis	GO:0001525	201	0.365
ureteric bud development	GO:0001657	94	0.365
ventricular trabecula myocardium morphogenesis	GO:0003222	11	0.358	Mouse
regulation of cell migration	GO:0030334	219	0.354	Mouse
formation of primary germ layer	GO:0001704	77	0.353
negative regulation of cell proliferation	GO:0008285	296	0.350	Mouse
compartment pattern specification	GO:0007386	4	0.348	Mouse Fly
dorsal aorta morphogenesis	GO:0035912	5	0.341
regulation of cardiac cell fate specification	GO:2000043	1	0.339	Fly
positive regulation of cellular amino acid metabolic process	GO:0045764	3	0.336
regulation of canonical wnt signaling pathway	GO:0060828	82	0.333	Mouse
lung alveolus development	GO:0048286	45	0.330
regulation of osteoblast differentiation	GO:0045667	67	0.328	Mouse
renal vesicle induction	GO:0072034	3	0.327
synapse organization	GO:0050808	125	0.321
cranial nerve development	GO:0021545	41	0.318
telencephalon development	GO:0021537	186	0.315
somitogenesis	GO:0001756	69	0.315	Mouse
muscular septum morphogenesis	GO:0003150	4	0.303
positive regulation of cell adhesion	GO:0045785	80	0.302
negative regulation of cell fate specification	GO:0009996	4	0.302
embryonic limb morphogenesis	GO:0030326	126	0.299	Mouse
retinal blood vessel morphogenesis	GO:0061304	3	0.298
embryonic heart tube development	GO:0035050	65	0.294	Mouse
transmembrane receptor protein tyrosine kinase signaling pathway	GO:0007169	247	0.292
peptidyl tyrosine modification	GO:0018212	145	0.292
single organismal cell cell adhesion	GO:0016337	131	0.288
negative regulation of neuron projection development	GO:0010977	50	0.288
small gtpase mediated signal transduction	GO:0007264	97	0.286
salivary gland morphogenesis	GO:0007435	33	0.285
palate development	GO:0060021	76	0.284
cell type specific apoptotic process	GO:0097285	268	0.284
facial nerve development	GO:0021561	11	0.283
mesonephros development	GO:0001823	97	0.283
bmp signaling pathway	GO:0030509	93	0.281	Mouse
cardiac cell fate specification	GO:0060912	2	0.278	Fly
ear development	GO:0043583	200	0.275	Mouse
nephron tubule morphogenesis	GO:0072078	68	0.274
autonomic nervous system development	GO:0048483	43	0.274
neural tube patterning	GO:0021532	43	0.272
gastrulation	GO:0007369	116	0.272
tissue migration	GO:0090130	68	0.268	Fly
lymphocyte differentiation	GO:0030098	242	0.267
extracellular structure organization	GO:0043062	148	0.267	Mouse
regulation of mapk cascade	GO:0043408	248	0.261
chemotaxis	GO:0006935	247	0.261	Fly
muscle cell development	GO:0055001	133	0.260	Mouse
nephron morphogenesis	GO:0072028	69	0.256
mesonephric epithelium development	GO:0072163	94	0.255
regulation of bmp signaling pathway	GO:0030510	60	0.255	Mouse
cell fate determination	GO:0001709	32	0.248	Fly
mesenchyme development	GO:0060485	152	0.247	Mouse
muscle cell differentiation	GO:0042692	261	0.247	Mouse Fly
epithelial cell proliferation	GO:0050673	174	0.246	Mouse Fly
digestive tract morphogenesis	GO:0048546	147	0.243	Mouse Fly
ameboidal type cell migration	GO:0001667	128	0.242	Fly
regulation of cell motility	GO:2000145	236	0.240	Mouse
regulation of protein targeting	GO:1903533	61	0.239
gonad development	GO:0008406	141	0.237	Worm
developmental maturation	GO:0021700	193	0.236	Mouse
negative regulation of nervous system development	GO:0051961	156	0.233
regulation of cell projection organization	GO:0031344	206	0.232	Fly
cerebellum development	GO:0021549	77	0.231
negative regulation of myeloid cell differentiation	GO:0045638	38	0.230
negative regulation of osteoblast differentiation	GO:0045668	30	0.229	Mouse
amine metabolic process	GO:0009308	45	0.229
regulation of epithelial cell proliferation	GO:0050678	141	0.228	Mouse
regulation of endothelial cell migration	GO:0010594	22	0.227
aorta development	GO:0035904	23	0.222
clara cell differentiation	GO:0060486	4	0.222
wound healing	GO:0042060	157	0.221	Mouse Rat
regulation of extracellular matrix assembly	GO:1901201	2	0.215	Mouse
oviduct development	GO:0060066	3	0.213
negative regulation of endothelial cell migration	GO:0010596	4	0.212
bone development	GO:0060348	120	0.211
endothelial cell migration	GO:0043542	44	0.211
regulation of binding	GO:0051098	111	0.210
morphogenesis of embryonic epithelium	GO:0016331	159	0.210
endocardial cell differentiation	GO:0060956	4	0.208	Mouse
outflow tract morphogenesis	GO:0003151	53	0.207
membrane organization	GO:0061024	245	0.207
epidermis development	GO:0008544	187	0.205	Mouse
sensory perception	GO:0007600	245	0.202
kidney morphogenesis	GO:0060993	83	0.200
ascending aorta morphogenesis	GO:0035910	3	0.199
retina development in camera type eye	GO:0060041	119	0.198
development of primary sexual characteristics	GO:0045137	143	0.195	Worm
striated muscle tissue development	GO:0014706	293	0.194	Mouse Fly
regulation of cell activation	GO:0050865	289	0.194
extracellular matrix assembly	GO:0085029	12	0.194	Mouse
regulation of system process	GO:0044057	200	0.193
regulation of epithelial to mesenchymal transition	GO:0010717	22	0.192	Mouse
negative regulation of cell development	GO:0010721	169	0.192
epithelial to mesenchymal transition involved in endocardial cushion formation	GO:0003198	10	0.191	Mouse
aorta morphogenesis	GO:0035909	22	0.191
peptidyl tyrosine phosphorylation	GO:0018108	143	0.191
regulation of ras gtpase activity	GO:0032318	88	0.188
organ growth	GO:0035265	117	0.187	Mouse
epithelium migration	GO:0090132	63	0.186	Fly
negative regulation of gastrulation	GO:2000542	3	0.185
heart valve morphogenesis	GO:0003179	21	0.183	Mouse
positive regulation of cellular amine metabolic process	GO:0033240	5	0.183
tube formation	GO:0035148	140	0.182
epithelial cell migration	GO:0010631	63	0.181	Fly
epithelial tube formation	GO:0072175	130	0.180
mapk cascade	GO:0000165	281	0.178
nephron tubule development	GO:0072080	84	0.178	Mouse
bone mineralization	GO:0030282	54	0.177
purine nucleoside metabolic process	GO:0042278	241	0.177
developmental growth involved in morphogenesis	GO:0060560	138	0.175	Mouse
negative regulation of molecular function	GO:0044092	258	0.175	Mouse
nephron epithelium development	GO:0072009	92	0.173	Mouse
appendage development	GO:0048736	166	0.172	Mouse Fly
central nervous system projection neuron axonogenesis	GO:0021952	21	0.172
cellular response to organonitrogen compound	GO:0071417	145	0.171
neuron migration	GO:0001764	122	0.169
regulation of angiogenesis	GO:0045765	81	0.168
axon guidance	GO:0007411	141	0.168	Fly
cardiac chamber development	GO:0003205	108	0.164	Mouse
ras protein signal transduction	GO:0007265	77	0.162
cerebellar granule cell precursor tangential migration	GO:0021935	1	0.162
retinal ganglion cell axon guidance	GO:0031290	18	0.162
cardiac ventricle morphogenesis	GO:0003208	50	0.162	Mouse
regulation of intracellular transport	GO:0032386	159	0.162
regulation of vasculature development	GO:1901342	88	0.161
positive regulation of protein modification process	GO:0031401	299	0.161
rac protein signal transduction	GO:0016601	13	0.161
neuron death	GO:0070997	154	0.159
nucleoside triphosphate catabolic process	GO:0009143	205	0.159
mesonephric tubule morphogenesis	GO:0072171	63	0.159
negative regulation of canonical wnt signaling pathway	GO:0090090	51	0.158	Mouse
negative regulation of transmembrane receptor protein serine threonine kinase signaling pathway	GO:0090101	61	0.157	Mouse
heart morphogenesis	GO:0003007	178	0.157	Mouse
regulation of intracellular protein transport	GO:0033157	82	0.156
transmembrane receptor protein serine threonine kinase signaling pathway	GO:0007178	194	0.155	Mouse
negative regulation of wnt signaling pathway	GO:0030178	73	0.154	Mouse
epithelial to mesenchymal transition	GO:0001837	47	0.154	Mouse
regulation of muscle tissue development	GO:1901861	97	0.154	Mouse
mitral valve morphogenesis	GO:0003183	4	0.150
canonical wnt signaling pathway	GO:0060070	130	0.149	Mouse
digestive tract development	GO:0048565	190	0.149	Mouse Worm Fly
cellular response to acid chemical	GO:0071229	68	0.148
hippo signaling	GO:0035329	11	0.147
trachea cartilage morphogenesis	GO:0060535	4	0.146
cell migration involved in endocardial cushion formation	GO:0003273	3	0.145	Mouse
ureteric bud morphogenesis	GO:0060675	62	0.145
homeostasis of number of cells	GO:0048872	210	0.143	Fly
regulation of cellular catabolic process	GO:0031329	242	0.143
synapse assembly	GO:0007416	56	0.142
cellular amine metabolic process	GO:0044106	44	0.142
limbic system development	GO:0021761	72	0.141
protein import into nucleus	GO:0006606	95	0.140
mitral valve development	GO:0003174	4	0.140
negative regulation of immune system process	GO:0002683	209	0.140	Mouse
regeneration	GO:0031099	38	0.139	Rat
leukocyte differentiation	GO:0002521	342	0.139	Mouse
foregut morphogenesis	GO:0007440	12	0.139	Mouse Fly
heart contraction	GO:0060047	93	0.138
spinal cord development	GO:0021510	81	0.136
inner ear morphogenesis	GO:0042472	101	0.132
cardiac right atrium morphogenesis	GO:0003213	3	0.132	Mouse
central nervous system neuron development	GO:0021954	67	0.132
negative regulation of cell migration	GO:0030336	59	0.132
defecation	GO:0030421	1	0.130
neuron apoptotic process	GO:0051402	142	0.129
endodermal cell fate specification	GO:0001714	4	0.129
positive regulation of ossification	GO:0045778	47	0.129
camera type eye development	GO:0043010	266	0.128	Mouse
pigmentation	GO:0043473	71	0.127
extracellular matrix organization	GO:0030198	147	0.126	Mouse
skeletal muscle fiber development	GO:0048741	58	0.125
limb morphogenesis	GO:0035108	149	0.125	Mouse
cell junction assembly	GO:0034329	52	0.125
vagus nerve development	GO:0021564	3	0.124
positive regulation of cell projection organization	GO:0031346	95	0.124
ventral spinal cord development	GO:0021517	48	0.124
central nervous system neuron axonogenesis	GO:0021955	28	0.124
auditory receptor cell differentiation	GO:0042491	37	0.123	Mouse
negative regulation of photoreceptor cell differentiation	GO:0046533	4	0.123	Mouse Fly
muscle cell migration	GO:0014812	19	0.121
negative regulation of leukocyte differentiation	GO:1902106	51	0.121
gtp catabolic process	GO:0006184	143	0.120
negative regulation of fat cell differentiation	GO:0045599	36	0.119
regulation of protein serine threonine kinase activity	GO:0071900	157	0.118
cardiac endothelial cell differentiation	GO:0003348	4	0.118	Mouse
motor neuron axon guidance	GO:0008045	26	0.115	Fly
positive regulation of growth	GO:0045927	104	0.115	Mouse
bone morphogenesis	GO:0060349	78	0.115
regulation of auditory receptor cell differentiation	GO:0045607	4	0.115
regulation of neuron death	GO:1901214	134	0.114
regulation of striated muscle cell differentiation	GO:0051153	81	0.114	Mouse
positive regulation of extracellular matrix organization	GO:1903055	4	0.114
positive regulation of map kinase activity	GO:0043406	84	0.113
purine nucleoside triphosphate catabolic process	GO:0009146	203	0.113
smooth muscle cell migration	GO:0014909	10	0.113
negative regulation of cellular component organization	GO:0051129	194	0.113
forebrain neuron differentiation	GO:0021879	52	0.113
purine ribonucleotide metabolic process	GO:0009150	290	0.111
negative regulation of cell projection organization	GO:0031345	56	0.111
ribonucleotide metabolic process	GO:0009259	291	0.111
positive regulation of neuroblast proliferation	GO:0002052	19	0.110
regulation of stem cell differentiation	GO:2000736	50	0.110	Mouse Fly
aortic valve morphogenesis	GO:0003180	4	0.110
metencephalon development	GO:0022037	89	0.109
regulation of map kinase activity	GO:0043405	120	0.109
negative regulation of cartilage development	GO:0061037	17	0.109
regulation of transferase activity	GO:0051338	263	0.107
somatic stem cell maintenance	GO:0035019	47	0.107	Zebrafish
positive regulation of apoptotic process	GO:0043065	217	0.106	Mouse
morphogenesis of an epithelial sheet	GO:0002011	27	0.105	Mouse
regulation of cell substrate adhesion	GO:0010810	73	0.104
positive regulation of cell substrate adhesion	GO:0010811	47	0.104
central nervous system vasculogenesis	GO:0022009	3	0.103
forebrain cell migration	GO:0021885	58	0.103
negative regulation of protein metabolic process	GO:0051248	282	0.103
ear morphogenesis	GO:0042471	118	0.103
regulation of neural retina development	GO:0061074	3	0.102
mechanoreceptor differentiation	GO:0042490	67	0.102	Mouse
cell fate specification	GO:0001708	72	0.102	Mouse Worm Fly
peptidyl amino acid modification	GO:0018193	336	0.102
metanephros development	GO:0001656	79	0.102
regulation of stem cell proliferation	GO:0072091	78	0.101
forebrain generation of neurons	GO:0021872	63	0.100
negative regulation of cell motility	GO:2000146	61	0.100
spinal cord ventral commissure morphogenesis	GO:0021965	2	0.100
somite specification	GO:0001757	4	0.100
endochondral bone morphogenesis	GO:0060350	50	0.100
neuron recognition	GO:0008038	25	0.099
wnt signaling pathway planar cell polarity pathway	GO:0060071	27	0.099
spinal cord motor neuron differentiation	GO:0021522	35	0.099
regulation of secretion	GO:0051046	274	0.099	Mouse
cell matrix adhesion	GO:0007160	68	0.097
neuroblast differentiation	GO:0014016	2	0.097	Fly
hematopoietic progenitor cell differentiation	GO:0002244	143	0.097	Mouse
nephron epithelium morphogenesis	GO:0072088	68	0.096
developmental cell growth	GO:0048588	84	0.095
regulation of notch signaling pathway	GO:0008593	35	0.095	Fly
cerebellum morphogenesis	GO:0021587	42	0.094
commissural neuron axon guidance	GO:0071679	8	0.094
regulation of epithelial cell migration	GO:0010632	35	0.094
organonitrogen compound catabolic process	GO:1901565	264	0.094
regulation of protein import into nucleus	GO:0042306	52	0.093
brain morphogenesis	GO:0048854	32	0.093
cellular response to lipid	GO:0071396	145	0.092
cell recognition	GO:0008037	83	0.092
gonadotrophin releasing hormone neuronal migration to the hypothalamus	GO:0021828	3	0.092
positive regulation of mapk cascade	GO:0043410	170	0.091
carbohydrate homeostasis	GO:0033500	128	0.091
endocardial cushion to mesenchymal transition involved in heart valve formation	GO:0003199	4	0.091
negative regulation of mesodermal cell fate specification	GO:0042662	3	0.090
regulation of osteoblast proliferation	GO:0033688	15	0.090
atrioventricular valve morphogenesis	GO:0003181	13	0.090	Mouse
regulation of protein transport	GO:0051223	163	0.089
neuron projection extension	GO:1990138	64	0.088
mammary gland epithelium development	GO:0061180	65	0.088
cell fate commitment involved in formation of primary germ layer	GO:0060795	26	0.088
cell substrate adhesion	GO:0031589	130	0.088
positive regulation of protein serine threonine kinase activity	GO:0071902	106	0.088
positive regulation of mesenchymal cell proliferation	GO:0002053	33	0.088
regulation of protein localization	GO:0032880	231	0.087
regulation of cytoplasmic transport	GO:1903649	112	0.087
negative regulation of notch signaling pathway	GO:0045746	14	0.087
myeloid cell differentiation	GO:0030099	233	0.087	Mouse
ventricular cardiac muscle tissue morphogenesis	GO:0055010	32	0.086	Mouse
regulation of establishment of protein localization	GO:0070201	181	0.086
tongue development	GO:0043586	18	0.086
neuron projection extension involved in neuron projection guidance	GO:1902284	14	0.086
mesenchymal cell differentiation	GO:0048762	107	0.086	Mouse
cardiac septum development	GO:0003279	59	0.085	Mouse
cardiac chamber morphogenesis	GO:0003206	93	0.085	Mouse
response to organonitrogen compound	GO:0010243	246	0.085	Mouse
negative regulation of cell morphogenesis involved in differentiation	GO:0010771	48	0.085
neuroblast fate determination	GO:0007400	1	0.085	Fly
t cell differentiation	GO:0030217	174	0.085
single organism nuclear import	GO:1902593	95	0.085
exocrine system development	GO:0035272	45	0.084
cardiac atrium development	GO:0003230	24	0.084	Mouse
negative regulation of cell cycle	GO:0045786	123	0.084
b cell activation	GO:0042113	161	0.083
endodermal cell fate determination	GO:0007493	2	0.083
anterior commissure morphogenesis	GO:0021960	6	0.083
determination of left right symmetry	GO:0007368	80	0.082	Mouse
cell cell signaling involved in cell fate commitment	GO:0045168	35	0.082	Worm Fly
positive regulation of ureteric bud formation	GO:0072107	3	0.081
salivary gland development	GO:0007431	37	0.081
regulation of synaptic growth at neuromuscular junction	GO:0008582	4	0.081
negative regulation of catenin import into nucleus	GO:0035414	2	0.080
wnt signaling pathway involved in somitogenesis	GO:0090244	4	0.080
establishment or maintenance of cell polarity	GO:0007163	86	0.080
cytoplasmic transport	GO:0016482	234	0.080
regulation of hippo signaling	GO:0035330	1	0.080
regulation of catenin import into nucleus	GO:0035412	5	0.079
negative regulation of mesenchymal cell proliferation	GO:0072201	3	0.079
glomerular mesangial cell differentiation	GO:0072008	3	0.079	Mouse
response to organic cyclic compound	GO:0014070	198	0.079
plasma membrane organization	GO:0007009	90	0.077
hormone secretion	GO:0046879	128	0.077
endoderm formation	GO:0001706	20	0.076
regulation of cellular component biogenesis	GO:0044087	181	0.076	Mouse Fly
cardiac septum morphogenesis	GO:0060411	46	0.076	Mouse
formation of organ boundary	GO:0010160	1	0.076	Fly
endothelium development	GO:0003158	45	0.076	Mouse
negative regulation of neuron death	GO:1901215	98	0.076
tube closure	GO:0060606	91	0.076
cell differentiation involved in kidney development	GO:0061005	33	0.076	Mouse
hippocampus development	GO:0021766	52	0.076
inner cell mass cellular morphogenesis	GO:0001828	1	0.075
regulation of removal of superoxide radicals	GO:2000121	4	0.075
lung morphogenesis	GO:0060425	50	0.075
positive regulation of binding	GO:0051099	49	0.075
regulation of anatomical structure size	GO:0090066	178	0.074	Zebrafish
pharynx development	GO:0060465	1	0.074	Worm
renal vesicle development	GO:0072087	17	0.073
multicellular organism growth	GO:0035264	161	0.073
digestive system development	GO:0055123	200	0.073	Mouse Worm Fly
regulation of retina development in camera type eye	GO:1902866	3	0.073
positive regulation of cell morphogenesis involved in differentiation	GO:0010770	72	0.072	Mouse
sprouting angiogenesis	GO:0002040	26	0.072	Mouse
blood vessel endothelial cell migration	GO:0043534	23	0.072
ascending aorta development	GO:0035905	3	0.072
regulation of protein kinase activity	GO:0045859	232	0.072
planar cell polarity pathway involved in ventricular septum morphogenesis	GO:0061348	2	0.072
protein localization to nucleus	GO:0034504	121	0.071
striated muscle cell development	GO:0055002	125	0.071
negative regulation of phosphate metabolic process	GO:0045936	184	0.070
regulation of transmembrane receptor protein serine threonine kinase signaling pathway	GO:0090092	112	0.070	Mouse
wnt signaling pathway involved in forebrain neuroblast division	GO:0021874	2	0.070
cell differentiation in spinal cord	GO:0021515	53	0.069
neural plate development	GO:0001840	12	0.069	Zebrafish
positive regulation of bmp signaling pathway	GO:0030513	23	0.069	Mouse
nuclear transport	GO:0051169	139	0.069
epithelial cell differentiation involved in kidney development	GO:0035850	23	0.069	Mouse
astrocyte fate commitment	GO:0060018	4	0.069
branching involved in ureteric bud morphogenesis	GO:0001658	56	0.068
cardiac muscle cell differentiation	GO:0055007	69	0.068
cerebral cortex cell migration	GO:0021795	44	0.068
prostate gland morphogenesis	GO:0060512	32	0.067	Mouse
sensory organ morphogenesis	GO:0090596	242	0.067	Mouse Fly
regulation of neuron apoptotic process	GO:0043523	122	0.067
ribonucleoside triphosphate metabolic process	GO:0009199	220	0.066
muscle tissue morphogenesis	GO:0060415	53	0.066	Mouse
positive regulation of stem cell proliferation	GO:2000648	59	0.066
glomerulus development	GO:0032835	40	0.066
negative regulation of smooth muscle cell migration	GO:0014912	2	0.065
oligodendrocyte differentiation	GO:0048709	53	0.065	Zebrafish Mouse
positive regulation of neuron differentiation	GO:0045666	141	0.065
protein targeting	GO:0006605	143	0.065
biomineral tissue development	GO:0031214	64	0.064
negative regulation of epithelial cell proliferation	GO:0050680	64	0.064
substrate dependent cerebral cortex tangential migration	GO:0021825	3	0.064
positive regulation of muscle tissue development	GO:1901863	32	0.064	Mouse
ribonucleoside catabolic process	GO:0042454	206	0.064
axon extension involved in axon guidance	GO:0048846	14	0.064
negative regulation of growth	GO:0045926	99	0.064
telencephalon cell migration	GO:0022029	55	0.063
muscle system process	GO:0003012	141	0.063
positive regulation of hydrolase activity	GO:0051345	148	0.063
regulation of cell cycle	GO:0051726	281	0.063	Worm Fly
pro b cell differentiation	GO:0002328	10	0.063	Mouse
regulation of vasculogenesis	GO:2001212	9	0.063
nucleoside phosphate metabolic process	GO:0006753	338	0.063
positive regulation of cell motility	GO:2000147	116	0.062	Mouse
cell cell adhesion	GO:0098609	41	0.062	Fly
establishment of planar polarity involved in neural tube closure	GO:0090177	15	0.062
cognition	GO:0050890	149	0.062	Fly
response to acid chemical	GO:0001101	111	0.062
mesoderm morphogenesis	GO:0048332	64	0.062
notochord development	GO:0030903	20	0.062
regulation of lymphocyte activation	GO:0051249	240	0.061
muscle contraction	GO:0006936	101	0.061
regulation of lymphocyte differentiation	GO:0045619	107	0.061
regulation of neural precursor cell proliferation	GO:2000177	70	0.060
cellular homeostasis	GO:0019725	240	0.060
positive regulation of protein kinase activity	GO:0045860	144	0.060
peripheral nervous system development	GO:0007422	53	0.060	Zebrafish Fly
neural precursor cell proliferation	GO:0061351	121	0.060	Zebrafish
neural crest cell differentiation	GO:0014033	54	0.060
regulation of organ morphogenesis	GO:2000027	144	0.060	Mouse Fly
epithelial cell proliferation involved in prostatic bud elongation	GO:0060517	1	0.059
myotube differentiation	GO:0014902	105	0.059	Mouse
regulation of nucleocytoplasmic transport	GO:0046822	73	0.059
regulation of mesenchymal cell proliferation	GO:0010464	37	0.059
negative regulation of phosphorylation	GO:0042326	166	0.059
inner ear receptor cell differentiation	GO:0060113	61	0.058	Mouse
neural crest cell migration	GO:0001755	32	0.058
cardiac ventricle development	GO:0003231	83	0.058	Mouse
forebrain neuron development	GO:0021884	30	0.058
carbohydrate derivative catabolic process	GO:1901136	231	0.058
regulation of leukocyte differentiation	GO:1902105	159	0.058	Mouse
regulation of establishment of planar polarity involved in neural tube closure	GO:0090178	15	0.058
non canonical wnt signaling pathway via jnk cascade	GO:0038031	3	0.058
determination of heart left right asymmetry	GO:0061371	48	0.058	Mouse
response to decreased oxygen levels	GO:0036293	59	0.057	Mouse
elastic fiber assembly	GO:0048251	4	0.057
preganglionic parasympathetic nervous system development	GO:0021783	17	0.056
mesoderm formation	GO:0001707	62	0.056
heart valve formation	GO:0003188	10	0.056
endothelial cell differentiation	GO:0045446	41	0.055	Mouse
fat cell differentiation	GO:0045444	160	0.055
negative regulation of phosphorus metabolic process	GO:0010563	184	0.055
planar cell polarity pathway involved in axis elongation	GO:0003402	4	0.054
diencephalon development	GO:0021536	63	0.054
intracellular protein transport	GO:0006886	204	0.054
heart process	GO:0003015	94	0.054
mammary gland duct morphogenesis	GO:0060603	38	0.054
morphogenesis of an endothelium	GO:0003159	2	0.054
dorsal ventral axon guidance	GO:0033563	3	0.053
dendrite development	GO:0016358	115	0.053
establishment of planar polarity of embryonic epithelium	GO:0042249	16	0.053
gliogenesis	GO:0042063	141	0.053	Zebrafish Mouse Fly
lens morphogenesis in camera type eye	GO:0002089	24	0.053
hindbrain morphogenesis	GO:0021575	46	0.053
renal vesicle morphogenesis	GO:0072077	15	0.053
branchiomotor neuron axon guidance	GO:0021785	7	0.053
regulation of bone mineralization	GO:0030500	31	0.053
lung field specification	GO:0060424	3	0.052
organic cyclic compound catabolic process	GO:1901361	295	0.052
cellular response to heparin	GO:0071504	1	0.052
coronary vasculature development	GO:0060976	12	0.052	Mouse

Notch3 disease predictions

Disease predictions are made from cross-annotation of human disease genes to the identified functional analogs in mouse and predicted with the mouse functional network.

	Disease	DO term ID	Size	Probability	Func Analog Org
	disease of anatomical entity	DOID:7	0	0.076
	musculoskeletal system disease	DOID:17	0	0.076

Loading network...

Network Filters

Minimum relationship confidence:

Maximum number of genes:

Highlight known relationships in gold.

Graphical Options

Adjust edge length:

Adjust node size:

Fixed layout

Black background

Low confidence color:

Med confidence color:

High confidence color:

Hide the legend in the network