Mus musculus

40 known processes

Raph1

Ras association (RalGDS/AF-6) and pleckstrin homology domains 1

(Aliases: 9430025M21Rik,C730009O10Rik)

Raph1 biological process predictions


Filter by process size:
Biological processGO term IDProcess sizeProbabilityFunc Analog Org
cellular amine metabolic processGO:0044106440.089
cellular amino acid metabolic processGO:00065201030.079
regulation of cellular amino acid metabolic processGO:000652150.076
amine metabolic processGO:0009308450.066
regulation of cellular ketone metabolic processGO:0010565660.060
cellular ketone metabolic processGO:0042180840.057
ras protein signal transductionGO:0007265770.057
positive regulation of cellular amino acid metabolic processGO:004576430.054
small gtpase mediated signal transductionGO:0007264970.053
regulation of cellular amine metabolic processGO:0033238200.051
transmembrane transportGO:00550854120.051
oxidation reduction processGO:00551143420.049
mapk cascadeGO:00001652810.046
positive regulation of cellular amine metabolic processGO:003324050.045
ion transmembrane transportGO:00342203610.045
glycosyl compound metabolic processGO:19016572460.044
cation transportGO:00068123990.044
peptidyl amino acid modificationGO:00181933360.043
regulation of organelle organizationGO:00330432890.042
cellular lipid metabolic processGO:00442553230.041
cellular nitrogen compound catabolic processGO:00442702800.041
heterocycle catabolic processGO:00467002800.041
nucleoside phosphate metabolic processGO:00067533380.039
nucleoside metabolic processGO:00091162460.039
axonogenesisGO:00074092740.039
purine nucleotide metabolic processGO:00061633020.038
organic cyclic compound catabolic processGO:19013612950.037
cation transmembrane transportGO:00986552660.036
response to organonitrogen compoundGO:00102432460.035
negative regulation of cellular amino acid metabolic processGO:004576300.035
purine ribonucleotide metabolic processGO:00091502900.034
positive regulation of protein modification processGO:00314012990.034
homeostasis of number of cellsGO:00488722100.034
regulation of mapk cascadeGO:00434082480.034
nucleobase containing small molecule metabolic processGO:00550863520.034
negative regulation of cellular amine metabolic processGO:003323910.034
ribose phosphate metabolic processGO:00196932910.034
aromatic compound catabolic processGO:00194392860.034
regulation of protein kinase activityGO:00458592320.034
ribonucleoside triphosphate metabolic processGO:00091992200.033
negative regulation of protein metabolic processGO:00512482820.033
purine containing compound metabolic processGO:00725213110.033
regulation of anatomical structure sizeGO:00900661780.033
regulation of hydrolase activityGO:00513362460.033
ribonucleotide metabolic processGO:00092592910.033
actin cytoskeleton organizationGO:00300362200.033
purine nucleoside metabolic processGO:00422782410.032
cytokine productionGO:00018163190.032
carbohydrate metabolic processGO:00059752300.032
lipid biosynthetic processGO:00086101790.031
purine ribonucleoside metabolic processGO:00461282410.031
intracellular protein transportGO:00068862040.031
regulation of synaptic growth at neuromuscular junctionGO:000858240.030
nitrogen compound transportGO:00717052710.030
ribonucleoside metabolic processGO:00091192450.030
membrane organizationGO:00610242450.030
negative regulation of phosphorus metabolic processGO:00105631840.030
glycosyl compound catabolic processGO:19016582060.029
ribonucleoside triphosphate catabolic processGO:00092031990.029
ribonucleoside catabolic processGO:00424542060.029
regulation of secretion by cellGO:19035302490.029
carbohydrate derivative catabolic processGO:19011362310.029
regulation of neuron differentiationGO:00456642810.029
regulation of cell projection organizationGO:00313442060.028
regulation of secretionGO:00510462740.028
cellular chemical homeostasisGO:00550822150.028
gland developmentGO:00487323300.028
ribonucleotide catabolic processGO:00092612080.028
rho protein signal transductionGO:0007266320.028
posttranscriptional regulation of gene expressionGO:00106081550.028
male gamete generationGO:00482322850.028
regulation of cell motilityGO:20001452360.027
regulation of protein localizationGO:00328802310.027
sensory perceptionGO:00076002450.027
synapse organizationGO:00508081250.027
nucleotide metabolic processGO:00091173320.027
macromolecule catabolic processGO:00090572810.027
spermatogenesisGO:00072832840.027
muscle tissue developmentGO:00605373080.027
cell adhesionGO:00071553290.027
positive regulation of cellular catabolic processGO:00313311480.027
endomembrane system organizationGO:00102561470.027
purine nucleoside catabolic processGO:00061522050.027
organophosphate catabolic processGO:00464342320.027
inorganic cation transmembrane transportGO:00986622070.027
organonitrogen compound catabolic processGO:19015652640.026
camera type eye developmentGO:00430102660.026
cell type specific apoptotic processGO:00972852680.026
forebrain developmentGO:00309003020.026
inorganic ion transmembrane transportGO:00986602340.026
organic hydroxy compound metabolic processGO:19016152030.026
leukocyte differentiationGO:00025213420.026
purine containing compound catabolic processGO:00725232130.026
myeloid cell differentiationGO:00300992330.026
cellular protein complex assemblyGO:00436231160.026
cellular response to organonitrogen compoundGO:00714171450.026
sensory organ morphogenesisGO:00905962420.026
positive regulation of cell developmentGO:00107202370.026
regulation of transferase activityGO:00513382630.026
protein catabolic processGO:00301632210.025
anion transportGO:00068201770.025
muscle cell differentiationGO:00426922610.025
negative regulation of molecular functionGO:00440922580.025
nucleoside triphosphate catabolic processGO:00091432050.025
regulation of cell migrationGO:00303342190.024
fat cell differentiationGO:00454441600.024
respiratory system developmentGO:00605411900.024
t cell activationGO:00421102890.024
regulation of cellular component biogenesisGO:00440871810.024
spermatid differentiationGO:00485151150.024
apoptotic signaling pathwayGO:00971903060.024
rhodopsin mediated signaling pathwayGO:001605640.024
striated muscle tissue developmentGO:00147062930.023
multicellular organismal signalingGO:0035637910.023
regulation of nucleoside metabolic processGO:00091181300.023
epidermis developmentGO:00085441870.023
nucleoside catabolic processGO:00091642060.023
positive regulation of protein phosphorylationGO:00019342420.023
muscle system processGO:00030121410.023
nucleoside phosphate catabolic processGO:19012922220.023
cytoplasmic transportGO:00164822340.023
negative regulation of cell proliferationGO:00082852960.023
chemotaxisGO:00069352470.023
circulatory system processGO:00030131970.023
purine nucleotide catabolic processGO:00061952110.023
regulation of cellular catabolic processGO:00313292420.023
regulation of cell morphogenesis involved in differentiationGO:00107691510.023
response to organic cyclic compoundGO:00140701980.023
regulation of cytoskeleton organizationGO:00514931220.023
g protein coupled receptor signaling pathwayGO:00071862430.023
organic anion transportGO:00157111370.023
regulation of apoptotic signaling pathwayGO:20012331970.022
negative regulation of intracellular signal transductionGO:19025321670.022
purine nucleoside triphosphate metabolic processGO:00091442260.022
nucleoside triphosphate metabolic processGO:00091412300.022
negative regulation of phosphorylationGO:00423261660.022
urogenital system developmentGO:00016552610.022
regulation of membrane potentialGO:00423911920.022
wnt signaling pathwayGO:00160551880.022
organonitrogen compound biosynthetic processGO:19015661920.022
transmembrane receptor protein tyrosine kinase signaling pathwayGO:00071692470.022
regulation of cytokine productionGO:00018172660.022
blood circulationGO:00080151950.022
transmembrane receptor protein serine threonine kinase signaling pathwayGO:00071781940.022
negative regulation of protein modification processGO:00314001630.021
skeletal system developmentGO:00015013560.021
kidney developmentGO:00018222130.021
regulation of cell activationGO:00508652890.021
carbohydrate derivative biosynthetic processGO:19011371830.021
establishment of organelle localizationGO:00516561220.021
immune effector processGO:00022523210.021
transmission of nerve impulseGO:0019226760.021
purine ribonucleotide catabolic processGO:00091542080.021
negative regulation of cellular component organizationGO:00511291940.021
dephosphorylationGO:00163111290.021
protein modification by small protein conjugation or removalGO:00706472070.021
organelle localizationGO:00516401790.021
epithelial cell developmentGO:00020641590.021
regulation of nucleotide metabolic processGO:00061401690.021
positive regulation of purine nucleotide metabolic processGO:19005441140.021
regulation of ras protein signal transductionGO:00465781140.021
retrograde transport endosome to golgiGO:004214720.021
small molecule biosynthetic processGO:00442831320.021
cell substrate adhesionGO:00315891300.020
cellular ion homeostasisGO:00068731650.020
cellular response to lipidGO:00713961450.020
divalent inorganic cation transportGO:00725111780.020
negative regulation of cellular protein metabolic processGO:00322692470.020
purine nucleoside triphosphate catabolic processGO:00091462030.020
skin developmentGO:00435882200.020
synaptic transmissionGO:00072683290.020
actin filament organizationGO:00070151130.020
positive regulation of organelle organizationGO:00106381280.020
cellular homeostasisGO:00197252400.020
divalent metal ion transportGO:00708381720.019
regulation of homeostatic processGO:00328441820.019
developmental growth involved in morphogenesisGO:00605601380.019
respiratory tube developmentGO:00303231670.019
neuron deathGO:00709971540.019
endocytosisGO:00068971680.019
protein localization to organelleGO:00333651850.019
regulation of lymphocyte activationGO:00512492400.019
lymphocyte differentiationGO:00300982420.019
regulation of hormone levelsGO:00108172110.019
nucleotide catabolic processGO:00091662170.019
positive regulation of nervous system developmentGO:00519622210.019
reactive oxygen species metabolic processGO:0072593840.019
guanosine containing compound catabolic processGO:19010691440.019
regulation of actin nucleationGO:005112540.019
stem cell differentiationGO:00488632680.019
protein localization to membraneGO:00726571080.019
embryonic organ morphogenesisGO:00485622760.019
lateral inhibitionGO:004633110.019
regulation of cell cycleGO:00517262810.018
cation homeostasisGO:00550802120.018
negative regulation of phosphate metabolic processGO:00459361840.018
action potentialGO:0001508780.018
skeletal muscle organ developmentGO:00605381630.018
regulation of vesicle mediated transportGO:00606271390.018
protein modification by small protein conjugationGO:00324461870.018
fatty acid metabolic processGO:00066311210.018
actin polymerization or depolymerizationGO:0008154540.018
calcium ion transportGO:00068161590.018
regulation of response to woundingGO:19030341890.018
hematopoietic progenitor cell differentiationGO:00022441430.018
germ cell developmentGO:00072811850.018
neuron apoptotic processGO:00514021420.018
steroid metabolic processGO:00082021190.018
anatomical structure homeostasisGO:00602491450.018
negative regulation of protein phosphorylationGO:00019331260.018
regulation of ras gtpase activityGO:0032318880.018
maintenance of locationGO:0051235890.018
positive regulation of kinase activityGO:00336741550.018
purine ribonucleoside catabolic processGO:00461302050.018
regulation of t cell activationGO:00508631700.018
microtubule based processGO:00070172360.018
monocarboxylic acid metabolic processGO:00327871910.018
stem cell developmentGO:00488642190.018
regulation of ossificationGO:00302781120.017
alcohol metabolic processGO:00060661160.017
regulation of kinase activityGO:00435492490.017
muscle cell developmentGO:00550011330.017
response to lipopolysaccharideGO:00324961280.017
gtp catabolic processGO:00061841430.017
ear developmentGO:00435832000.017
regulation of defense responseGO:00313472330.017
organic acid transportGO:00158491010.017
positive regulation of hydrolase activityGO:00513451480.017
carboxylic acid transportGO:00469421000.017
regulation of ion transportGO:00432692150.017
regulation of nucleotide catabolic processGO:00308111220.017
regulation of cellular component sizeGO:00325351210.017
glycoprotein biosynthetic processGO:0009101890.017
dna metabolic processGO:00062593030.017
muscle contractionGO:00069361010.017
renal system developmentGO:00720012250.017
cellular response to dna damage stimulusGO:00069742070.017
retina development in camera type eyeGO:00600411190.017
regulation of actin filament based processGO:0032970990.017
spermatid developmentGO:00072861080.017
regulation of protein serine threonine kinase activityGO:00719001570.017
neuronal action potentialGO:0019228540.017
digestive system developmentGO:00551232000.017
positive regulation of gtp catabolic processGO:0033126850.017
purine ribonucleoside triphosphate metabolic processGO:00092052200.016
glycoprotein metabolic processGO:00091001160.016
regulation of ion transmembrane transportGO:00347651190.016
positive regulation of cell deathGO:00109422240.016
amide transportGO:00428861380.016
positive regulation of nucleotide metabolic processGO:00459811140.016
peptidyl tyrosine modificationGO:00182121450.016
purine ribonucleoside triphosphate catabolic processGO:00092071990.016
regulation of intracellular transportGO:00323861590.016
activation of immune responseGO:00022531380.016
negative regulation of cell developmentGO:00107211690.016
regulation of protein catabolic processGO:00421761080.016
protein polymerizationGO:0051258570.016
epithelial tube morphogenesisGO:00605623030.016
cellular response to hormone stimulusGO:00328701500.016
protein targetingGO:00066051430.016
positive regulation of ras gtpase activityGO:0032320650.016
cognitionGO:00508901490.016
innate immune responseGO:00450871570.016
cellular macromolecule catabolic processGO:00442652060.016
peptidyl tyrosine phosphorylationGO:00181081430.016
lipid localizationGO:00108761260.016
peptide transportGO:00158331330.016
positive regulation of apoptotic processGO:00430652170.016
dendrite developmentGO:00163581150.016
negative regulation of nervous system developmentGO:00519611560.016
glycerolipid metabolic processGO:00464861220.016
organelle fissionGO:00482851700.016
multicellular organismal homeostasisGO:00488711640.016
response to peptideGO:19016521360.016
photoreceptor cell differentiationGO:0046530520.016
axon guidanceGO:00074111410.016
leukocyte proliferationGO:00706611720.016
regulation of transmembrane receptor protein serine threonine kinase signaling pathwayGO:00900921120.015
cellular response to biotic stimulusGO:0071216920.015
regulation of voltage gated calcium channel activityGO:190138540.015
angiogenesisGO:00015252010.015
positive regulation of mapk cascadeGO:00434101700.015
positive regulation of actin nucleationGO:005112730.015
telencephalon developmentGO:00215371860.015
lipid transportGO:0006869980.015
positive regulation of transferase activityGO:00513471670.015
regulation of protein transportGO:00512231630.015
carbohydrate homeostasisGO:00335001280.015
regulation of metal ion transportGO:00109591060.015
ossificationGO:00015032160.015
positive regulation of cellular component biogenesisGO:0044089940.015
myeloid cell homeostasisGO:00022621140.015
protein localization to nucleusGO:00345041210.015
cellular alcohol biosynthetic processGO:004410830.015
modification dependent macromolecule catabolic processGO:00436321330.015
regulation of protein complex assemblyGO:0043254830.015
response to molecule of bacterial originGO:00022371430.015
anion transmembrane transportGO:0098656710.015
tissue homeostasisGO:00018941150.015
blood vessel morphogenesisGO:00485142850.015
positive regulation of nucleoside metabolic processGO:0045979910.015
extracellular structure organizationGO:00430621480.015
compound eye developmentGO:004874910.015
glucose homeostasisGO:00425931280.015
glycerophospholipid metabolic processGO:0006650710.015
regulation of neuron projection developmentGO:00109751690.015
establishment of vesicle localizationGO:0051650810.014
tube formationGO:00351481400.014
regulation of gtp catabolic processGO:00331241130.014
guanosine containing compound metabolic processGO:19010681440.014
microtubule cytoskeleton organizationGO:00002261570.014
regulation of neuron deathGO:19012141340.014
nuclear transportGO:00511691390.014
neuron migrationGO:00017641220.014
response to acid chemicalGO:00011011110.014
regionalizationGO:00030023370.014
regulation of cellular response to stressGO:00801351590.014
cellular carbohydrate metabolic processGO:00442621190.014
canonical wnt signaling pathwayGO:00600701300.014
negative regulation of immune system processGO:00026832090.014
morphogenesis of a branching epitheliumGO:00611381930.014
sequestering of calcium ionGO:0051208180.014
rap protein signal transductionGO:003248630.014
engulfment of apoptotic cellGO:004365230.014
positive regulation of protein kinase activityGO:00458601440.014
actin filament polymerizationGO:0030041440.014
immune response regulating signaling pathwayGO:00027641250.014
cellular response to external stimulusGO:0071496880.014
regulation of purine nucleotide metabolic processGO:19005421690.014
protein ubiquitinationGO:00165671710.014
cellular response to cytokine stimulusGO:00713451890.014
positive regulation of programmed cell deathGO:00430682180.014
regulation of neuron apoptotic processGO:00435231220.014
cofactor metabolic processGO:0051186800.014
striated muscle contractionGO:0006941450.014
regulation of establishment of protein localizationGO:00702011810.014
chromatin organizationGO:00063252060.014
cell junction organizationGO:0034330770.014
t cell differentiationGO:00302171740.014
regulation of transmembrane transportGO:00347621280.014
negative regulation of growthGO:0045926990.014
regulation of actin filament lengthGO:0030832450.014
vesicle localizationGO:0051648860.014
regulation of proteolysisGO:00301621640.014
adult behaviorGO:00305341350.014
sequestering of metal ionGO:0051238190.014
morphogenesis of a branching structureGO:00017632030.014
developmental maturationGO:00217001930.014
extrinsic apoptotic signaling pathwayGO:00971911260.014
striated muscle cell developmentGO:00550021250.014
tube closureGO:0060606910.014
modification dependent protein catabolic processGO:00199411330.014
positive regulation of cell motilityGO:20001471160.013
response to peptide hormoneGO:00434341270.013
positive regulation of nucleotide catabolic processGO:0030813880.013
positive regulation of cell activationGO:00508671580.013
calcium ion transmembrane transportGO:0070588850.013
regulation of purine nucleotide catabolic processGO:00331211220.013
exocytosisGO:00068871210.013
regulation of cell cycle processGO:00105641600.013
response to radiationGO:00093141650.013
leukocyte activation involved in immune responseGO:00023661260.013
metal ion homeostasisGO:00550651890.013
plasma membrane organizationGO:0007009900.013
leukocyte migrationGO:00509001240.013
positive regulation of cell migrationGO:00303351090.013
cellular calcium ion homeostasisGO:00068741190.013
embryonic epithelial tube formationGO:00018381300.013
single organism nuclear importGO:1902593950.013
protein maturationGO:00516041760.013
myeloid leukocyte differentiationGO:00025731190.013
response to inorganic substanceGO:0010035960.013
regulation of peptidyl tyrosine phosphorylationGO:0050730930.013
regulation of leukocyte proliferationGO:00706631210.013
epithelial cell proliferationGO:00506731740.013
divalent inorganic cation homeostasisGO:00725071380.013
organic acid biosynthetic processGO:0016053860.013
heart contractionGO:0060047930.013
carboxylic acid biosynthetic processGO:0046394860.013
regulation of system processGO:00440572000.013
positive regulation of purine nucleotide catabolic processGO:0033123880.013
multi multicellular organism processGO:00447061090.013
single organism cell adhesionGO:00986021560.013
gtp metabolic processGO:00460391440.013
neuromuscular processGO:0050905990.013
inflammatory responseGO:00069542440.013
developmental cell growthGO:0048588840.013
organelle assemblyGO:00709251770.013
regulation of bindingGO:00510981110.013
regulation of organ morphogenesisGO:20000271440.013
regulation of cell adhesionGO:00301551540.013
ameboidal type cell migrationGO:00016671280.013
neural tube developmentGO:00219151600.013
mitochondrion organizationGO:00070051340.012
learning or memoryGO:00076111480.012
myotube differentiationGO:00149021050.012
regulation of endocytosisGO:0030100690.012
neural tube formationGO:00018411080.012
fertilizationGO:00095661270.012
protein importGO:00170381010.012
organic hydroxy compound transportGO:0015850930.012
mesodermal cell migrationGO:000807840.012
cellular protein catabolic processGO:00442571550.012
negative regulation of transferase activityGO:0051348850.012
regulation of hippo signalingGO:003533010.012
proteolysis involved in cellular protein catabolic processGO:00516031470.012
regulation of multi organism processGO:00439001110.012
rhythmic processGO:00485111740.012
pallium developmentGO:00215431200.012
central nervous system neuron differentiationGO:00219531620.012
lymphocyte proliferationGO:00466511640.012
heart processGO:0003015940.012
neuron projection guidanceGO:00974851410.012
placenta developmentGO:00018901400.012
locomotory behaviorGO:00076261950.012
phospholipid metabolic processGO:0006644870.012
regulation of lymphocyte proliferationGO:00506701170.012
response to growth factorGO:00708481980.012
protein localization to plasma membraneGO:0072659570.012
regulation of feeding behaviorGO:006025930.012
cell activation involved in immune responseGO:00022631260.012
gliogenesisGO:00420631410.012
nuclear importGO:0051170950.012
ubiquitin dependent protein catabolic processGO:00065111290.012
intrinsic apoptotic signaling pathwayGO:00971931320.012
negative regulation of synapse assemblyGO:005196430.012
cellular response to growth factor stimulusGO:00713631970.012
detection of stimulusGO:0051606840.012
nuclear divisionGO:00002801580.012
nucleocytoplasmic transportGO:00069131390.012
reactive nitrogen species metabolic processGO:200105700.012
cellular response to organic cyclic compoundGO:0071407870.012
organophosphate biosynthetic processGO:00904071220.012
regulation of cell substrate adhesionGO:0010810730.012
wound healingGO:00420601570.012
bmp signaling pathwayGO:0030509930.012
response to light stimulusGO:00094161350.011
reactive oxygen species biosynthetic processGO:190340980.011
organ growthGO:00352651170.011
negative regulation of defense responseGO:0031348770.011
inner ear morphogenesisGO:00424721010.011
membrane tubulationGO:009732040.011
regulation of rho protein signal transductionGO:0035023710.011
positive regulation of secretion by cellGO:19035321140.011
single organismal cell cell adhesionGO:00163371310.011
localization within membraneGO:005166840.011
regulation of ion transmembrane transporter activityGO:0032412540.011
erk1 and erk2 cascadeGO:0070371770.011
protein import into nucleusGO:0006606950.011
nucleoside monophosphate metabolic processGO:0009123850.011
regulation of body fluid levelsGO:00508781620.011
macromolecule methylationGO:00434141200.011
positive regulation of phagocytosis engulfmentGO:006010030.011
regulation of engulfment of apoptotic cellGO:190107420.011
morphogenesis of embryonic epitheliumGO:00163311590.011
calcium ion homeostasisGO:00550741270.011
heart morphogenesisGO:00030071780.011
protein processingGO:00164851630.011
negative regulation of apoptotic signaling pathwayGO:20012341040.011
mitotic cytokinesisGO:000028140.011
peptide hormone secretionGO:00300721090.011
muscle fiber developmentGO:0048747760.011
purine nucleoside monophosphate metabolic processGO:0009126810.011
t cell proliferationGO:00420981200.011
organic hydroxy compound biosynthetic processGO:1901617770.011
sodium ion transportGO:0006814730.011
response to insulinGO:00328681000.011
regulation of translationGO:0006417710.011
positive regulation of secretionGO:00510471300.011
cell cell junction organizationGO:0045216720.011
epithelium migrationGO:0090132630.011
ribonucleoside monophosphate metabolic processGO:0009161800.011
negative regulation of neuron deathGO:1901215980.011
mitotic cell cycleGO:00002781950.011
interleukin 8 productionGO:003263740.011
negative regulation of organelle organizationGO:0010639900.011
epithelial tube formationGO:00721751300.011
mesoderm developmentGO:00074981000.011
positive regulation of lymphocyte activationGO:00512511400.011
positive regulation of cell adhesionGO:0045785800.011
regulation of leukocyte differentiationGO:19021051590.011

Raph1 disease predictions

Disease predictions are made from cross-annotation of human disease genes to the identified functional analogs in mouse and predicted with the mouse functional network.

DiseaseDO term IDSizeProbabilityFunc Analog Org
musculoskeletal system diseaseDOID:1700.022
disease of anatomical entityDOID:700.022
cancerDOID:16200.020
disease of cellular proliferationDOID:1456600.020
organ system cancerDOID:005068600.020
immune system diseaseDOID:291400.019
nervous system diseaseDOID:86300.018
disease of metabolismDOID:001466700.018
inherited metabolic disorderDOID:65500.016
connective tissue diseaseDOID:6500.015
bone diseaseDOID:008000100.015
hematopoietic system diseaseDOID:7400.015
cardiovascular system diseaseDOID:128700.011
central nervous system diseaseDOID:33100.011