IMP: Integrative Multi-species Prediction

Mus musculus

38 known processes

Tgfa

transforming growth factor alpha

(Aliases: wa1,wa-1)

Ensembl: ENSMUSG00000029999
Entrez: 21802
UniProtKB: P48030
UniProtKB: Q545E4

Process Predictions
Disease Predictions

Tgfa biological process predictions

Show only novel predictionsHighlight processes of functional analogs

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Biological process	GO term ID	Process size	Probability	Func Analog Org
hair follicle development	GO:0001942	85	0.944
epithelial tube morphogenesis	GO:0060562	303	0.942
transmembrane receptor protein tyrosine kinase signaling pathway	GO:0007169	247	0.852
stem cell development	GO:0048864	219	0.840
positive regulation of cellular amino acid metabolic process	GO:0045764	3	0.801
regulation of cellular amino acid metabolic process	GO:0006521	5	0.777
positive regulation of cellular amine metabolic process	GO:0033240	5	0.776
regulation of transferase activity	GO:0051338	263	0.747	Human
epidermis development	GO:0008544	187	0.742
regulation of cell migration	GO:0030334	219	0.737
regulation of protein kinase activity	GO:0045859	232	0.736	Human
hair cycle	GO:0042633	90	0.730
positive regulation of protein kinase activity	GO:0045860	144	0.718	Human
cellular amino acid metabolic process	GO:0006520	103	0.713
positive regulation of rho gtpase activity	GO:0032321	41	0.700
regulation of cellular ketone metabolic process	GO:0010565	66	0.689
stem cell maintenance	GO:0019827	130	0.684
hair follicle morphogenesis	GO:0031069	29	0.672
mapk cascade	GO:0000165	281	0.660	Human
skin development	GO:0043588	220	0.643
stem cell differentiation	GO:0048863	268	0.637
positive regulation of transferase activity	GO:0051347	167	0.631	Human
regulation of cell motility	GO:2000145	236	0.620
somatic stem cell maintenance	GO:0035019	47	0.617
morphogenesis of a branching epithelium	GO:0061138	193	0.616
regulation of kinase activity	GO:0043549	249	0.611	Human
forebrain development	GO:0030900	302	0.610
regulation of cellular amine metabolic process	GO:0033238	20	0.601
positive regulation of kinase activity	GO:0033674	155	0.590	Human
positive regulation of intracellular transport	GO:0032388	70	0.576
g protein coupled receptor signaling pathway	GO:0007186	243	0.562
ameboidal type cell migration	GO:0001667	128	0.561
response to organonitrogen compound	GO:0010243	246	0.532
axis elongation involved in somitogenesis	GO:0090245	4	0.514
regulation of hormone levels	GO:0010817	211	0.510
cerebral cortex development	GO:0021987	86	0.494
non canonical wnt signaling pathway	GO:0035567	33	0.485
positive regulation of mapk cascade	GO:0043410	170	0.480	Human
negative regulation of cell proliferation	GO:0008285	296	0.475
regulation of protein serine threonine kinase activity	GO:0071900	157	0.466	Human
regulation of protein tyrosine kinase activity	GO:0061097	17	0.466	Human
regulation of mapk cascade	GO:0043408	248	0.458	Human
epidermis morphogenesis	GO:0048730	33	0.458
canonical wnt signaling pathway	GO:0060070	130	0.453
cellular amine metabolic process	GO:0044106	44	0.451
blood circulation	GO:0008015	195	0.451
leukocyte differentiation	GO:0002521	342	0.451
lymphocyte differentiation	GO:0030098	242	0.434
positive regulation of protein serine threonine kinase activity	GO:0071902	106	0.427	Human
apoptotic signaling pathway	GO:0097190	306	0.424
molting cycle	GO:0042303	90	0.422
positive regulation of protein phosphorylation	GO:0001934	242	0.419	Human
ossification	GO:0001503	216	0.415
regulation of map kinase activity	GO:0043405	120	0.412	Human
transmembrane receptor protein serine threonine kinase signaling pathway	GO:0007178	194	0.410
positive regulation of epidermal growth factor activated receptor activity	GO:0045741	2	0.409	Human
positive regulation of map kinase activity	GO:0043406	84	0.405	Human
epidermal growth factor receptor signaling pathway	GO:0007173	28	0.401
morphogenesis of a branching structure	GO:0001763	203	0.399
regulation of epithelial cell proliferation	GO:0050678	141	0.399	Human
positive regulation of cell migration	GO:0030335	109	0.394
wnt signaling pathway planar cell polarity pathway	GO:0060071	27	0.392
embryonic organ morphogenesis	GO:0048562	276	0.384
regulation of wnt signaling pathway	GO:0030111	123	0.383
regulation of cell activation	GO:0050865	289	0.373
epithelial cell proliferation	GO:0050673	174	0.372	Human
mammary gland morphogenesis	GO:0060443	54	0.366
establishment of planar polarity involved in neural tube closure	GO:0090177	15	0.363
insulin secretion	GO:0030073	89	0.361
morphogenesis of a polarized epithelium	GO:0001738	37	0.356
positive regulation of wnt signaling pathway	GO:0030177	45	0.352
regulation of epidermal growth factor activated receptor activity	GO:0007176	7	0.351	Human
wnt signaling pathway	GO:0016055	188	0.341
regulation of cytoskeleton organization	GO:0051493	122	0.340
planar cell polarity pathway involved in cardiac muscle tissue morphogenesis	GO:0061350	2	0.335
mammary gland duct morphogenesis	GO:0060603	38	0.335
circulatory system process	GO:0003013	197	0.333
regulation of epithelial cell migration	GO:0010632	35	0.333
axis elongation	GO:0003401	30	0.331
hormone secretion	GO:0046879	128	0.330
positive regulation of gtp catabolic process	GO:0033126	85	0.325
neural tube development	GO:0021915	160	0.324
skin morphogenesis	GO:0043589	38	0.323
actin cytoskeleton organization	GO:0030036	220	0.319
skeletal system development	GO:0001501	356	0.311
establishment of planar polarity	GO:0001736	28	0.311
axonogenesis	GO:0007409	274	0.309
regulation of establishment of planar polarity	GO:0090175	28	0.308
regulation of defense response	GO:0031347	233	0.307
cerebral cortex cell migration	GO:0021795	44	0.302
camera type eye development	GO:0043010	266	0.300
branch elongation of an epithelium	GO:0060602	19	0.288
gland development	GO:0048732	330	0.286
muscle cell proliferation	GO:0033002	52	0.281
keratinocyte differentiation	GO:0030216	48	0.277
planar cell polarity pathway involved in pericardium morphogenesis	GO:0061354	2	0.274
positive regulation of protein modification process	GO:0031401	299	0.274	Human
negative regulation of cell migration	GO:0030336	59	0.273
branching morphogenesis of an epithelial tube	GO:0048754	159	0.271
epithelium migration	GO:0090132	63	0.271
transmembrane transport	GO:0055085	412	0.267
synapse organization	GO:0050808	125	0.266
cardiac ventricle development	GO:0003231	83	0.264
regulation of receptor activity	GO:0010469	41	0.264	Human
positive regulation of cellular catabolic process	GO:0031331	148	0.264
activation of mapkk activity	GO:0000186	15	0.263
morphogenesis of an epithelial fold	GO:0060571	28	0.259
angiogenesis	GO:0001525	201	0.254
negative regulation of hydrolase activity	GO:0051346	71	0.252
protein maturation	GO:0051604	176	0.249
carbohydrate derivative biosynthetic process	GO:1901137	183	0.247
peptide hormone secretion	GO:0030072	109	0.247
t cell differentiation	GO:0030217	174	0.247
t cell differentiation in thymus	GO:0033077	77	0.247
positive regulation of apoptotic process	GO:0043065	217	0.246
positive regulation of purine nucleotide metabolic process	GO:1900544	114	0.246
amine metabolic process	GO:0009308	45	0.244
mesenchyme development	GO:0060485	152	0.244
regulation of transmembrane receptor protein serine threonine kinase signaling pathway	GO:0090092	112	0.243
regulation of neural precursor cell proliferation	GO:2000177	70	0.243
regulation of canonical wnt signaling pathway	GO:0060828	82	0.242
extrinsic apoptotic signaling pathway	GO:0097191	126	0.241
cellular ketone metabolic process	GO:0042180	84	0.240
negative regulation of ossification	GO:0030279	49	0.238
cellular homeostasis	GO:0019725	240	0.237
ureteric bud development	GO:0001657	94	0.235
regulation of ossification	GO:0030278	112	0.234
regionalization	GO:0003002	337	0.234
regulation of response to wounding	GO:1903034	189	0.231
establishment of tissue polarity	GO:0007164	28	0.228
bone remodeling	GO:0046849	53	0.227
ras protein signal transduction	GO:0007265	77	0.227
response to peptide	GO:1901652	136	0.226
heart morphogenesis	GO:0003007	178	0.221
morphogenesis of an epithelial sheet	GO:0002011	27	0.219
positive regulation of neural precursor cell proliferation	GO:2000179	42	0.219
regulation of cell adhesion	GO:0030155	154	0.214
cardiac septum morphogenesis	GO:0060411	46	0.213
genitalia development	GO:0048806	37	0.213
regulation of nucleotide metabolic process	GO:0006140	169	0.213
digestive tract morphogenesis	GO:0048546	147	0.212
telencephalon cell migration	GO:0022029	55	0.211
cellular response to hormone stimulus	GO:0032870	150	0.211
platelet derived growth factor receptor signaling pathway	GO:0048008	32	0.210
ear morphogenesis	GO:0042471	118	0.210
regulation of postsynaptic membrane potential	GO:0060078	48	0.208
positive regulation of epithelial cell migration	GO:0010634	19	0.208
central nervous system morphogenesis	GO:0021551	2	0.207
branching involved in mammary gland duct morphogenesis	GO:0060444	27	0.206
rho protein signal transduction	GO:0007266	32	0.206
peptidyl amino acid modification	GO:0018193	336	0.205	Human
negative regulation of cell motility	GO:2000146	61	0.205
mammary gland epithelium development	GO:0061180	65	0.204
cation transport	GO:0006812	399	0.203
positive regulation of cytoplasmic transport	GO:1903651	40	0.203
positive regulation of apoptotic signaling pathway	GO:2001235	95	0.203
mesonephric tubule development	GO:0072164	94	0.201
paraxial mesodermal cell fate commitment	GO:0048343	2	0.201
positive regulation of protein import into nucleus	GO:0042307	26	0.200
positive regulation of nucleotide metabolic process	GO:0045981	114	0.199
non canonical wnt signaling pathway involved in heart development	GO:0061341	3	0.198
negative regulation of molecular function	GO:0044092	258	0.198
wnt signaling pathway involved in forebrain neuroblast division	GO:0021874	2	0.198
cardiac chamber morphogenesis	GO:0003206	93	0.197
tissue migration	GO:0090130	68	0.196
pallium development	GO:0021543	120	0.195
tissue remodeling	GO:0048771	102	0.194
positive regulation of cyclic nucleotide biosynthetic process	GO:0030804	24	0.193
cardiac septum development	GO:0003279	59	0.192
small gtpase mediated signal transduction	GO:0007264	97	0.191
regulation of apoptotic signaling pathway	GO:2001233	197	0.190
determination of heart left right asymmetry	GO:0061371	48	0.189
regulation of transforming growth factor beta2 production	GO:0032909	2	0.188
regulation of rho gtpase activity	GO:0032319	58	0.188
t cell activation	GO:0042110	289	0.187
regulation of catenin import into nucleus	GO:0035412	5	0.187
planar cell polarity pathway involved in cardiac right atrium morphogenesis	GO:0061349	2	0.187
nucleoside phosphate metabolic process	GO:0006753	338	0.187
organonitrogen compound biosynthetic process	GO:1901566	192	0.187
epithelial cell migration	GO:0010631	63	0.184
response to extracellular stimulus	GO:0009991	127	0.184
planar cell polarity pathway involved in ventricular septum morphogenesis	GO:0061348	2	0.183
positive regulation of ras gtpase activity	GO:0032320	65	0.183
regulation of ion homeostasis	GO:2000021	64	0.180
negative regulation of transmembrane receptor protein serine threonine kinase signaling pathway	GO:0090101	61	0.179
planar cell polarity pathway involved in outflow tract morphogenesis	GO:0061347	2	0.178
anatomical structure homeostasis	GO:0060249	145	0.178
artery development	GO:0060840	53	0.177
negative regulation of phosphorus metabolic process	GO:0010563	184	0.176
telencephalon development	GO:0021537	186	0.175
anagen	GO:0042640	13	0.175
inner ear morphogenesis	GO:0042472	101	0.174
placenta development	GO:0001890	140	0.174
negative regulation of cellular protein metabolic process	GO:0032269	247	0.173
digestive system development	GO:0055123	200	0.173
gtp catabolic process	GO:0006184	143	0.170
sterol metabolic process	GO:0016125	58	0.169
blood vessel morphogenesis	GO:0048514	285	0.167
regulation of cytoplasmic transport	GO:1903649	112	0.166
dopaminergic neuron differentiation	GO:0071542	14	0.165
regulation of proteolysis	GO:0030162	164	0.165
bone resorption	GO:0045453	38	0.163
cardiac muscle tissue development	GO:0048738	130	0.162
canonical wnt signaling pathway involved in regulation of cell proliferation	GO:0044340	3	0.162
planar cell polarity pathway involved in heart morphogenesis	GO:0061346	3	0.162
establishment of planar polarity of embryonic epithelium	GO:0042249	16	0.161
regulation of protein transport	GO:0051223	163	0.161
regulation of homeostatic process	GO:0032844	182	0.160
positive regulation of canonical wnt signaling pathway	GO:0090263	29	0.160
neural tube formation	GO:0001841	108	0.160
lipid biosynthetic process	GO:0008610	179	0.160
oxygen homeostasis	GO:0032364	2	0.157
regulation of actin filament based process	GO:0032970	99	0.157
embryonic epithelial tube formation	GO:0001838	130	0.157
nitrogen compound transport	GO:0071705	271	0.156
male gamete generation	GO:0048232	285	0.152
positive regulation of cell cycle	GO:0045787	92	0.152	Human
positive regulation of peptidyl tyrosine phosphorylation	GO:0050731	61	0.152	Human
carboxylic acid biosynthetic process	GO:0046394	86	0.152
wound healing	GO:0042060	157	0.152	Rat
male sex differentiation	GO:0046661	109	0.151
neuroblast proliferation	GO:0007405	49	0.151
primary neural tube formation	GO:0014020	95	0.147
membrane organization	GO:0061024	245	0.143
regulation of hormone secretion	GO:0046883	88	0.143
paraxial mesodermal cell differentiation	GO:0048342	2	0.141
cellular response to external stimulus	GO:0071496	88	0.140
positive regulation of cell development	GO:0010720	237	0.139
embryonic heart tube morphogenesis	GO:0003143	51	0.138
cardiac chamber development	GO:0003205	108	0.137
positive regulation of cell cell adhesion mediated by cadherin	GO:2000049	2	0.137
regulation of peptidyl tyrosine phosphorylation	GO:0050730	93	0.137	Human
intracellular protein transport	GO:0006886	204	0.136
positive regulation of nervous system development	GO:0051962	221	0.136
mesonephros development	GO:0001823	97	0.135
urogenital system development	GO:0001655	261	0.134
negative regulation of inflammatory response	GO:0050728	61	0.134
regulation of peptide transport	GO:0090087	91	0.133
respiratory system development	GO:0060541	190	0.132
regulation of hydrolase activity	GO:0051336	246	0.131
skeletal system morphogenesis	GO:0048705	203	0.131
determination of left right symmetry	GO:0007368	80	0.130
steroid metabolic process	GO:0008202	119	0.129
cellular response to growth factor stimulus	GO:0071363	197	0.128
forebrain cell migration	GO:0021885	58	0.128
appendage morphogenesis	GO:0035107	149	0.128
stem cell proliferation	GO:0072089	117	0.128
positive regulation of intracellular protein transport	GO:0090316	42	0.127
regulation of osteoblast differentiation	GO:0045667	67	0.127
purine containing compound metabolic process	GO:0072521	311	0.127
lung induction	GO:0060492	3	0.126
regulation of system process	GO:0044057	200	0.125
forebrain generation of neurons	GO:0021872	63	0.124
gtp metabolic process	GO:0046039	144	0.124
regulation of inflammatory response	GO:0050727	147	0.124
aminoglycan metabolic process	GO:0006022	34	0.124
organic hydroxy compound metabolic process	GO:1901615	203	0.123
negative regulation of protein metabolic process	GO:0051248	282	0.122
positive regulation of receptor activity	GO:2000273	17	0.122	Human
jnk cascade	GO:0007254	72	0.122
stress activated mapk cascade	GO:0051403	80	0.122
thyroid stimulating hormone secreting cell differentiation	GO:0060129	4	0.122
ion transmembrane transport	GO:0034220	361	0.122
regulation of t cell activation	GO:0050863	170	0.119
planar cell polarity pathway involved in neural tube closure	GO:0090179	14	0.116
regulation of purine nucleotide metabolic process	GO:1900542	169	0.116
regulation of kidney development	GO:0090183	40	0.115
proteolysis involved in cellular protein catabolic process	GO:0051603	147	0.115
regulation of cellular response to growth factor stimulus	GO:0090287	82	0.114
regulation of protein targeting	GO:1903533	61	0.113
limb development	GO:0060173	166	0.113
ear development	GO:0043583	200	0.113
outflow tract morphogenesis	GO:0003151	53	0.112
ribose phosphate metabolic process	GO:0019693	291	0.112
male gonad development	GO:0008584	88	0.111
protein localization to organelle	GO:0033365	185	0.110
mammary gland lobule development	GO:0061377	22	0.110
positive regulation of mesenchymal cell proliferation	GO:0002053	33	0.109
regulation of nucleocytoplasmic transport	GO:0046822	73	0.109
stress activated protein kinase signaling cascade	GO:0031098	81	0.109
muscle tissue development	GO:0060537	308	0.107
epithelial tube formation	GO:0072175	130	0.107
peptide secretion	GO:0002790	114	0.107
positive regulation of protein localization to nucleus	GO:1900182	30	0.106
positive regulation of cell motility	GO:2000147	116	0.106
organic acid biosynthetic process	GO:0016053	86	0.106
regulation of secretion by cell	GO:1903530	249	0.105
regulation of organ morphogenesis	GO:2000027	144	0.105
negative regulation of wnt signaling pathway	GO:0030178	73	0.105
regulation of gtp catabolic process	GO:0033124	113	0.104
apoptotic process involved in development	GO:1902742	28	0.104
fibroblast growth factor receptor signaling pathway	GO:0008543	46	0.103
positive regulation of jnk cascade	GO:0046330	46	0.103
peptide transport	GO:0015833	133	0.103
regulation of leukocyte proliferation	GO:0070663	121	0.103
inflammatory response	GO:0006954	244	0.103
cognition	GO:0050890	149	0.103
forebrain neuroblast division	GO:0021873	9	0.102
gliogenesis	GO:0042063	141	0.102
organic anion transport	GO:0015711	137	0.102
negative regulation of cellular amine metabolic process	GO:0033239	1	0.101
negative regulation of cellular amino acid metabolic process	GO:0045763	0	0.101
alcohol metabolic process	GO:0006066	116	0.100
tissue regeneration	GO:0042246	22	0.100
regulation of heart contraction	GO:0008016	77	0.100
endothelial cell migration	GO:0043542	44	0.100
cell adhesion	GO:0007155	329	0.099
regulation of renal sodium excretion	GO:0035813	3	0.098
regulation of protein localization	GO:0032880	231	0.097
cartilage development	GO:0051216	140	0.097
bmp signaling pathway	GO:0030509	93	0.097
nucleoside metabolic process	GO:0009116	246	0.097
protein kinase b signaling	GO:0043491	74	0.096
negative regulation of epithelial cell proliferation	GO:0050680	64	0.096
regulation of intracellular transport	GO:0032386	159	0.096
protein processing	GO:0016485	163	0.096
lymphocyte homeostasis	GO:0002260	64	0.095
regulation of muscle tissue development	GO:1901861	97	0.095
renal system development	GO:0072001	225	0.094
tube closure	GO:0060606	91	0.093
organ growth	GO:0035265	117	0.093
regulation of protein catabolic process	GO:0042176	108	0.093
hormone metabolic process	GO:0042445	86	0.092
positive regulation of programmed cell death	GO:0043068	218	0.092
negative regulation of neuron differentiation	GO:0045665	101	0.092
striated muscle tissue development	GO:0014706	293	0.092
renal vesicle induction	GO:0072034	3	0.092
protein localization to nucleus	GO:0034504	121	0.092
guanosine containing compound catabolic process	GO:1901069	144	0.091
regulation of stress activated mapk cascade	GO:0032872	69	0.091
endocrine system development	GO:0035270	98	0.091
positive regulation of cell adhesion	GO:0045785	80	0.090
ribonucleotide metabolic process	GO:0009259	291	0.090
regulation of stem cell proliferation	GO:0072091	78	0.090
negative regulation of cellular component organization	GO:0051129	194	0.089
embryonic appendage morphogenesis	GO:0035113	126	0.089
single organism cell adhesion	GO:0098602	156	0.089
positive regulation of nucleocytoplasmic transport	GO:0046824	30	0.089
cardiac right atrium morphogenesis	GO:0003213	3	0.089
regulation of leukocyte differentiation	GO:1902105	159	0.089
cellular response to extracellular stimulus	GO:0031668	81	0.088
negative regulation of cell morphogenesis involved in differentiation	GO:0010771	48	0.088
positive regulation of response to wounding	GO:1903036	66	0.087
developmental cell growth	GO:0048588	84	0.087
purine ribonucleoside metabolic process	GO:0046128	241	0.087
cardiac atrium morphogenesis	GO:0003209	23	0.086
morphogenesis of embryonic epithelium	GO:0016331	159	0.086
midbrain development	GO:0030901	35	0.086
response to oxidative stress	GO:0006979	123	0.086
protein import into nucleus	GO:0006606	95	0.086
mesonephric duct formation	GO:0072181	2	0.086
regulation of establishment of planar polarity involved in neural tube closure	GO:0090178	15	0.085
positive regulation of stress activated mapk cascade	GO:0032874	48	0.085
androgen biosynthetic process	GO:0006702	4	0.085
metencephalon development	GO:0022037	89	0.085
regulation of extrinsic apoptotic signaling pathway	GO:2001236	77	0.084
actin filament organization	GO:0007015	113	0.084
purine nucleotide metabolic process	GO:0006163	302	0.084
polarity specification of proximal distal axis	GO:0010085	2	0.083
nuclear import	GO:0051170	95	0.082
response to growth factor	GO:0070848	198	0.082
developmental programmed cell death	GO:0010623	41	0.082
single organism nuclear import	GO:1902593	95	0.081
purine ribonucleotide metabolic process	GO:0009150	290	0.081
positive regulation of protein tyrosine kinase activity	GO:0061098	10	0.081	Human
head morphogenesis	GO:0060323	34	0.080
negative regulation of canonical wnt signaling pathway	GO:0090090	51	0.079
somite development	GO:0061053	81	0.079
ribonucleoside metabolic process	GO:0009119	245	0.079
glucose homeostasis	GO:0042593	128	0.078
cell proliferation in external granule layer	GO:0021924	10	0.078
positive regulation of neuron projection development	GO:0010976	79	0.078
locomotory behavior	GO:0007626	195	0.078
response to organic cyclic compound	GO:0014070	198	0.078
trachea cartilage morphogenesis	GO:0060535	4	0.077
rac protein signal transduction	GO:0016601	13	0.076
hair cycle phase	GO:0044851	16	0.076
nephric duct formation	GO:0072179	4	0.076
regulation of cardioblast differentiation	GO:0051890	3	0.076
regulation of cell growth	GO:0001558	91	0.075
cell junction organization	GO:0034330	77	0.075
negative regulation of transforming growth factor beta receptor signaling pathway	GO:0030512	26	0.074
ventricular septum development	GO:0003281	42	0.074
regulation of body fluid levels	GO:0050878	162	0.074
regulation of purine nucleotide catabolic process	GO:0033121	122	0.074
regulation of peptidyl threonine phosphorylation	GO:0010799	12	0.074
tube formation	GO:0035148	140	0.074
positive regulation of proteolysis	GO:0045862	85	0.074
maintenance of cell number	GO:0098727	3	0.073
regulation of mesenchymal cell proliferation	GO:0010464	37	0.073
salivary gland morphogenesis	GO:0007435	33	0.073
appendage development	GO:0048736	166	0.073
neural tube closure	GO:0001843	90	0.073
positive regulation of transmembrane receptor protein serine threonine kinase signaling pathway	GO:0090100	43	0.072
mesonephric duct morphogenesis	GO:0072180	4	0.072
adenylate cyclase modulating g protein coupled receptor signaling pathway	GO:0007188	54	0.072
negative regulation of cell development	GO:0010721	169	0.072
hindbrain formation	GO:0021576	1	0.072
bone development	GO:0060348	120	0.072
positive regulation of cyclic nucleotide metabolic process	GO:0030801	24	0.072
developmental growth involved in morphogenesis	GO:0060560	138	0.072
response to steroid hormone	GO:0048545	56	0.071
mesenchymal cell differentiation	GO:0048762	107	0.071
regulation of establishment of protein localization	GO:0070201	181	0.071
glycosaminoglycan metabolic process	GO:0030203	34	0.070
positive regulation of protein transport	GO:0051222	93	0.070
inorganic cation transmembrane transport	GO:0098662	207	0.070
macromolecule catabolic process	GO:0009057	281	0.070
muscle cell differentiation	GO:0042692	261	0.070
regulation of cellular catabolic process	GO:0031329	242	0.069
epithelial cell differentiation involved in mammary gland alveolus development	GO:0061030	4	0.069
aromatic compound catabolic process	GO:0019439	286	0.068
positive regulation of ossification	GO:0045778	47	0.068
leukocyte apoptotic process	GO:0071887	71	0.068
regulation of secretion	GO:0051046	274	0.067
regulation of bmp signaling pathway	GO:0030510	60	0.067
purine ribonucleoside triphosphate metabolic process	GO:0009205	220	0.067
mitral valve development	GO:0003174	4	0.067
positive regulation of hydrolase activity	GO:0051345	148	0.067
oviduct development	GO:0060066	3	0.066
negative regulation of cell growth	GO:0030308	44	0.066
kidney development	GO:0001822	213	0.066
negative regulation of immune system process	GO:0002683	209	0.066
extracellular structure organization	GO:0043062	148	0.065
positive regulation of cell death	GO:0010942	224	0.065
cell matrix adhesion	GO:0007160	68	0.065
negative regulation of growth	GO:0045926	99	0.065
positive regulation of epithelial cell proliferation involved in lung morphogenesis	GO:0060501	3	0.065
neural precursor cell proliferation	GO:0061351	121	0.065
epithelial to mesenchymal transition	GO:0001837	47	0.065
positive regulation of camp mediated signaling	GO:0043950	3	0.064
mesoderm development	GO:0007498	100	0.064
t cell apoptotic process	GO:0070231	39	0.064
regulation of sequence specific dna binding transcription factor activity	GO:0051090	106	0.064
regulation of cell cycle	GO:0051726	281	0.064	Human
single organismal cell cell adhesion	GO:0016337	131	0.064
nucleotide metabolic process	GO:0009117	332	0.064
alpha beta t cell activation	GO:0046631	91	0.063
lymphocyte apoptotic process	GO:0070227	54	0.063
gastrulation	GO:0007369	116	0.063
regulation of peptidase activity	GO:0052547	96	0.063
regulation of protein import into nucleus	GO:0042306	52	0.063
cytokine mediated signaling pathway	GO:0019221	115	0.063
developmental maturation	GO:0021700	193	0.062
negative regulation of neuron projection development	GO:0010977	50	0.062
endothelial cell differentiation	GO:0045446	41	0.062
carbohydrate metabolic process	GO:0005975	230	0.062
amide transport	GO:0042886	138	0.062
regulation of endothelial cell migration	GO:0010594	22	0.062
regulation of protein maturation	GO:1903317	96	0.062
renal inner medulla development	GO:0072053	3	0.062
divalent inorganic cation transport	GO:0072511	178	0.061
hindbrain development	GO:0030902	128	0.061
foregut regionalization	GO:0060423	3	0.061
positive regulation of canonical wnt signaling pathway involved in controlling type b pancreatic cell proliferation	GO:2000081	1	0.060
endocrine process	GO:0050886	39	0.060
mechanoreceptor differentiation	GO:0042490	67	0.060
regulation of intracellular protein transport	GO:0033157	82	0.060
regulation of epidermal cell differentiation	GO:0045604	21	0.060
mesenchymal cell proliferation	GO:0010463	44	0.060
mesonephric epithelium development	GO:0072163	94	0.060
gas homeostasis	GO:0033483	3	0.059
purine ribonucleotide catabolic process	GO:0009154	208	0.059
positive regulation of epithelial cell proliferation	GO:0050679	68	0.059	Human
renal outer medulla development	GO:0072054	2	0.059
adult behavior	GO:0030534	135	0.059
regulation of muscle contraction	GO:0006937	49	0.059
positive regulation of nucleoside metabolic process	GO:0045979	91	0.058
non canonical wnt signaling pathway via jnk cascade	GO:0038031	3	0.058
carbohydrate homeostasis	GO:0033500	128	0.058
cell surface receptor signaling pathway involved in heart development	GO:0061311	15	0.058
limb morphogenesis	GO:0035108	149	0.058
rhythmic process	GO:0048511	174	0.058
positive regulation of gtpase activity	GO:0043547	85	0.058
modification dependent macromolecule catabolic process	GO:0043632	133	0.058
peptidyl tyrosine modification	GO:0018212	145	0.058	Human
regulation of lymphocyte activation	GO:0051249	240	0.057
paraxial mesoderm development	GO:0048339	18	0.057
cellular chemical homeostasis	GO:0055082	215	0.057
positive regulation of catenin import into nucleus	GO:0035413	2	0.057
regulation of epidermis development	GO:0045682	33	0.057
positive regulation of protein catabolic process	GO:0045732	60	0.056
cation transmembrane transport	GO:0098655	266	0.056
epithelial cell proliferation involved in mammary gland duct elongation	GO:0060750	5	0.056
regulation of mitotic cell cycle	GO:0007346	126	0.056	Human
regulation of heart morphogenesis	GO:2000826	22	0.056
cellular divalent inorganic cation homeostasis	GO:0072503	127	0.055
positive regulation of secretion by cell	GO:1903532	114	0.055
regulation of vasculature development	GO:1901342	88	0.055
lung field specification	GO:0060424	3	0.055
wnt signaling pathway calcium modulating pathway	GO:0007223	2	0.055
endoderm development	GO:0007492	45	0.055
digestive tract development	GO:0048565	190	0.054

Tgfa disease predictions

Disease predictions are made from cross-annotation of human disease genes to the identified functional analogs in mouse and predicted with the mouse functional network.

	Disease	DO term ID	Size	Probability	Func Analog Org
	disease of anatomical entity	DOID:7	0	0.075
	musculoskeletal system disease	DOID:17	0	0.075

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