IMP: Integrative Multi-species Prediction

Mus musculus

19 known processes

Wdr78

WD repeat domain 78

(Aliases: BC028975,MGC38950,MGC31722)

Entrez: 242584
Ensembl: ENSMUSG00000035126
UniProtKB: E9PYY5

Process Predictions
Disease Predictions

Wdr78 biological process predictions

Show only novel predictionsHighlight processes of functional analogs

Filter by process size:

Biological process	GO term ID	Process size	Probability	Func Analog Org
cellular component assembly involved in morphogenesis	GO:0010927	139	0.228
cilium morphogenesis	GO:0060271	102	0.159
inorganic cation transmembrane transport	GO:0098662	207	0.127
response to organonitrogen compound	GO:0010243	246	0.121
spermatogenesis	GO:0007283	284	0.121	Fly
ribonucleotide metabolic process	GO:0009259	291	0.121
purine ribonucleotide metabolic process	GO:0009150	290	0.111
ribose phosphate metabolic process	GO:0019693	291	0.093
male gamete generation	GO:0048232	285	0.085	Fly
spermatid differentiation	GO:0048515	115	0.076
nucleoside triphosphate metabolic process	GO:0009141	230	0.069
microtubule based movement	GO:0007018	84	0.065
tissue homeostasis	GO:0001894	115	0.063
nucleoside phosphate metabolic process	GO:0006753	338	0.062
purine containing compound metabolic process	GO:0072521	311	0.062
synaptic transmission	GO:0007268	329	0.059
pole plasm assembly	GO:0007315	2	0.058
purine ribonucleotide catabolic process	GO:0009154	208	0.058
cation transport	GO:0006812	399	0.057
nucleoside metabolic process	GO:0009116	246	0.056
carboxylic acid transport	GO:0046942	100	0.054
circadian rhythm	GO:0007623	114	0.053
cilium assembly	GO:0042384	81	0.053
nucleobase containing small molecule metabolic process	GO:0055086	352	0.051
rac protein signal transduction	GO:0016601	13	0.049
locomotory behavior	GO:0007626	195	0.049
defecation	GO:0030421	1	0.048
anatomical structure homeostasis	GO:0060249	145	0.048
single organism cell adhesion	GO:0098602	156	0.048
sensory organ morphogenesis	GO:0090596	242	0.047
cellular response to insulin stimulus	GO:0032869	78	0.046
establishment of glial blood brain barrier	GO:0060857	2	0.045
chromatin organization	GO:0006325	206	0.044
cation transmembrane transport	GO:0098655	266	0.044
protein catabolic process	GO:0030163	221	0.043
microtubule based process	GO:0007017	236	0.043
regulation of hydrolase activity	GO:0051336	246	0.042
multicellular organismal homeostasis	GO:0048871	164	0.041
blood circulation	GO:0008015	195	0.041
muscle cell differentiation	GO:0042692	261	0.040
spermatid development	GO:0007286	108	0.038
dna metabolic process	GO:0006259	303	0.038
maternal determination of anterior posterior axis embryo	GO:0008358	2	0.036
inorganic ion transmembrane transport	GO:0098660	234	0.035
peptide hormone secretion	GO:0030072	109	0.034
cell adhesion	GO:0007155	329	0.034
response to radiation	GO:0009314	165	0.034
macromolecule catabolic process	GO:0009057	281	0.034
chromatin modification	GO:0016568	187	0.033
response to light stimulus	GO:0009416	135	0.032
detection of stimulus	GO:0051606	84	0.032
neurotransmitter transport	GO:0006836	76	0.032
organelle assembly	GO:0070925	177	0.032
organic anion transport	GO:0015711	137	0.032
heterocycle catabolic process	GO:0046700	280	0.031
camera type eye development	GO:0043010	266	0.031
cellular response to organonitrogen compound	GO:0071417	145	0.030
nitrogen compound transport	GO:0071705	271	0.030
peptide transport	GO:0015833	133	0.030
organonitrogen compound catabolic process	GO:1901565	264	0.030
cilium movement	GO:0003341	28	0.029
nucleotide metabolic process	GO:0009117	332	0.029
retina development in camera type eye	GO:0060041	119	0.029
positive regulation of cell activation	GO:0050867	158	0.029
purine containing compound catabolic process	GO:0072523	213	0.029
ras protein signal transduction	GO:0007265	77	0.029
amine metabolic process	GO:0009308	45	0.029
purine nucleoside triphosphate catabolic process	GO:0009146	203	0.028
retina homeostasis	GO:0001895	23	0.028
dna repair	GO:0006281	107	0.028
regulation of secretion	GO:0051046	274	0.028
proteasomal protein catabolic process	GO:0010498	98	0.027
purine ribonucleoside metabolic process	GO:0046128	241	0.027
peptide secretion	GO:0002790	114	0.027
modification dependent macromolecule catabolic process	GO:0043632	133	0.027
organic cyclic compound catabolic process	GO:1901361	295	0.027
forebrain development	GO:0030900	302	0.027
modification dependent protein catabolic process	GO:0019941	133	0.027
regulation of proteolysis	GO:0030162	164	0.027
epithelial cell proliferation	GO:0050673	174	0.026
purine nucleotide catabolic process	GO:0006195	211	0.026
gliogenesis	GO:0042063	141	0.026
skeletal system development	GO:0001501	356	0.026
anion transport	GO:0006820	177	0.026
intracellular mrna localization	GO:0008298	4	0.026
single organismal cell cell adhesion	GO:0016337	131	0.026
positive regulation of cellular amine metabolic process	GO:0033240	5	0.025
regulation of synaptic plasticity	GO:0048167	87	0.025
homeostasis of number of cells	GO:0048872	210	0.025
ubiquitin dependent protein catabolic process	GO:0006511	129	0.025
cellular homeostasis	GO:0019725	240	0.024
nucleoside phosphate biosynthetic process	GO:1901293	79	0.024
multicellular organism growth	GO:0035264	161	0.024
regulation of cellular component biogenesis	GO:0044087	181	0.024
epithelial cilium movement	GO:0003351	12	0.024
epithelial tube formation	GO:0072175	130	0.024
glycosyl compound metabolic process	GO:1901657	246	0.024
pharynx development	GO:0060465	1	0.024
amide transport	GO:0042886	138	0.024
embryonic skeletal system development	GO:0048706	120	0.023
regulation of gamma aminobutyric acid secretion	GO:0014052	2	0.023
organic hydroxy compound transport	GO:0015850	93	0.023
cellular response to acid chemical	GO:0071229	68	0.023
carbohydrate homeostasis	GO:0033500	128	0.022
rho protein signal transduction	GO:0007266	32	0.022
respiratory tube development	GO:0030323	167	0.022
positive regulation of cellular catabolic process	GO:0031331	148	0.022
positive regulation of cellular amino acid metabolic process	GO:0045764	3	0.021
negative regulation of t helper 2 cell differentiation	GO:0045629	4	0.021
nucleoside phosphate catabolic process	GO:1901292	222	0.021
regulation of cell activation	GO:0050865	289	0.021
purine ribonucleoside triphosphate catabolic process	GO:0009207	199	0.021
cation homeostasis	GO:0055080	212	0.021
adult behavior	GO:0030534	135	0.021
regulation of purine nucleotide metabolic process	GO:1900542	169	0.021
carbohydrate derivative catabolic process	GO:1901136	231	0.021
amino acid transport	GO:0006865	61	0.021
organic acid transport	GO:0015849	101	0.021
regulation of nucleotide metabolic process	GO:0006140	169	0.021
protein processing	GO:0016485	163	0.021
negative regulation of cell activation	GO:0050866	111	0.021
regulation of hormone levels	GO:0010817	211	0.021
retina morphogenesis in camera type eye	GO:0060042	45	0.021
regulation of leukocyte differentiation	GO:1902105	159	0.021
lateral inhibition	GO:0046331	1	0.021
glycosyl compound catabolic process	GO:1901658	206	0.020
sensory perception of sound	GO:0007605	97	0.020
cellular response to abiotic stimulus	GO:0071214	56	0.020
olfactory learning	GO:0008355	2	0.020
regulation of cellular amine metabolic process	GO:0033238	20	0.020
small gtpase mediated signal transduction	GO:0007264	97	0.020
nucleoside catabolic process	GO:0009164	206	0.020
detection of abiotic stimulus	GO:0009582	60	0.020
negative regulation of lymphocyte activation	GO:0051250	91	0.020
oocyte anterior posterior axis specification	GO:0007314	2	0.020
regulation of cellular catabolic process	GO:0031329	242	0.020
proteolysis involved in cellular protein catabolic process	GO:0051603	147	0.019
regulation of secretion by cell	GO:1903530	249	0.019
sensory perception	GO:0007600	245	0.019
regulation of membrane potential	GO:0042391	192	0.019
skin development	GO:0043588	220	0.019
ribonucleotide catabolic process	GO:0009261	208	0.019
positive regulation of nucleotide metabolic process	GO:0045981	114	0.019
response to organic cyclic compound	GO:0014070	198	0.019
transmembrane transport	GO:0055085	412	0.019
organophosphate catabolic process	GO:0046434	232	0.019
negative regulation of cell development	GO:0010721	169	0.019
skeletal system morphogenesis	GO:0048705	203	0.019
purine nucleoside monophosphate metabolic process	GO:0009126	81	0.019
nucleoside monophosphate metabolic process	GO:0009123	85	0.019
compound eye development	GO:0048749	1	0.019
exocytosis	GO:0006887	121	0.019
epithelial tube morphogenesis	GO:0060562	303	0.018
ear morphogenesis	GO:0042471	118	0.018
male meiosis i	GO:0007141	16	0.018
spinal cord development	GO:0021510	81	0.018
regulation of striated muscle cell differentiation	GO:0051153	81	0.018
embryonic organ morphogenesis	GO:0048562	276	0.018
heart morphogenesis	GO:0003007	178	0.018
ribonucleoside catabolic process	GO:0042454	206	0.018
regulation of epithelial cell proliferation	GO:0050678	141	0.018
protein maturation	GO:0051604	176	0.018
photoreceptor cell differentiation	GO:0046530	52	0.018
cellular amino acid metabolic process	GO:0006520	103	0.018
tube formation	GO:0035148	140	0.018
cell maturation	GO:0048469	127	0.018
inner ear morphogenesis	GO:0042472	101	0.018
purine nucleoside metabolic process	GO:0042278	241	0.018
lipid localization	GO:0010876	126	0.018
ribonucleoside monophosphate catabolic process	GO:0009158	57	0.017
lymphocyte differentiation	GO:0030098	242	0.017
myeloid leukocyte differentiation	GO:0002573	119	0.017
peptidyl tyrosine modification	GO:0018212	145	0.017
oocyte axis specification	GO:0007309	2	0.017
cellular nitrogen compound catabolic process	GO:0044270	280	0.017
adult locomotory behavior	GO:0008344	91	0.017
action potential	GO:0001508	78	0.017
kidney development	GO:0001822	213	0.017
digestive system development	GO:0055123	200	0.017
regulation of system process	GO:0044057	200	0.017
negative regulation of protein maturation	GO:1903318	79	0.017
nucleoside triphosphate catabolic process	GO:0009143	205	0.017
regulation of peptidase activity	GO:0052547	96	0.017
potassium ion transmembrane transport	GO:0071805	43	0.016
regulation of nucleoside metabolic process	GO:0009118	130	0.016
regulation of cell adhesion	GO:0030155	154	0.016
rhythmic process	GO:0048511	174	0.016
purine nucleoside catabolic process	GO:0006152	205	0.016
maintenance of location	GO:0051235	89	0.016
embryonic limb morphogenesis	GO:0030326	126	0.016
respiratory system development	GO:0060541	190	0.016
ion transmembrane transport	GO:0034220	361	0.016
posttranscriptional regulation of gene expression	GO:0010608	155	0.016
regulation of purine nucleotide catabolic process	GO:0033121	122	0.016
g protein coupled acetylcholine receptor signaling pathway	GO:0007213	4	0.016
telencephalon development	GO:0021537	186	0.016
sensory perception of mechanical stimulus	GO:0050954	107	0.016
trachea cartilage morphogenesis	GO:0060535	4	0.015
appendage morphogenesis	GO:0035107	149	0.015
neural precursor cell proliferation	GO:0061351	121	0.015
ribonucleoside metabolic process	GO:0009119	245	0.015
glial cell differentiation	GO:0010001	131	0.015
regulation of peptide transport	GO:0090087	91	0.015
regulation of lymphocyte activation	GO:0051249	240	0.015
regulation of vesicle mediated transport	GO:0060627	139	0.015
oocyte construction	GO:0007308	2	0.015
regulation of protein catabolic process	GO:0042176	108	0.015
negative regulation of nervous system development	GO:0051961	156	0.015
positive regulation of protein modification process	GO:0031401	299	0.015
lung development	GO:0030324	164	0.015
mesonephric epithelium development	GO:0072163	94	0.015
cellular chemical homeostasis	GO:0055082	215	0.015
detection of mechanical stimulus involved in sensory perception of pain	GO:0050966	4	0.015
regulation of leukocyte mediated immunity	GO:0002703	104	0.015
extrinsic apoptotic signaling pathway	GO:0097191	126	0.015
purine ribonucleoside triphosphate metabolic process	GO:0009205	220	0.014
cellular response to hormone stimulus	GO:0032870	150	0.014
negative regulation of kinase activity	GO:0033673	81	0.014
microtubule based transport	GO:0010970	50	0.014
cell junction organization	GO:0034330	77	0.014
adenylate cyclase modulating g protein coupled receptor signaling pathway	GO:0007188	54	0.014
purine ribonucleoside catabolic process	GO:0046130	205	0.014
positive regulation of amino acid transport	GO:0051957	4	0.014
regulation of neurotransmitter levels	GO:0001505	87	0.014
stem cell fate specification	GO:0048866	3	0.014
response to peptide	GO:1901652	136	0.014
negative regulation of proteolysis	GO:0045861	74	0.014
detection of stimulus involved in sensory perception	GO:0050906	44	0.014
renal system development	GO:0072001	225	0.014
regulation of protein maturation	GO:1903317	96	0.014
sperm motility	GO:0030317	47	0.014
regulation of muscle contraction	GO:0006937	49	0.014
proteasome mediated ubiquitin dependent protein catabolic process	GO:0043161	88	0.014
ribonucleoside monophosphate metabolic process	GO:0009161	80	0.014
cellular potassium ion transport	GO:0071804	43	0.014
nucleotide biosynthetic process	GO:0009165	78	0.014
response to insulin	GO:0032868	100	0.014
purine nucleotide metabolic process	GO:0006163	302	0.014
anion transmembrane transport	GO:0098656	71	0.014
ventral midline development	GO:0007418	4	0.014
terminal button organization	GO:0072553	3	0.013
nucleoside monophosphate catabolic process	GO:0009125	59	0.013
hematopoietic progenitor cell differentiation	GO:0002244	143	0.013
negative regulation of protein metabolic process	GO:0051248	282	0.013
cell activation involved in immune response	GO:0002263	126	0.013
positive regulation of hydrolase activity	GO:0051345	148	0.013
visual behavior	GO:0007632	45	0.013
regulation of peptide secretion	GO:0002791	77	0.013
stem cell proliferation	GO:0072089	117	0.013
regulation of peptide hormone secretion	GO:0090276	75	0.013
atp catabolic process	GO:0006200	55	0.013
blood vessel morphogenesis	GO:0048514	285	0.013
regulation of intracellular transport	GO:0032386	159	0.013
gall bladder development	GO:0061010	2	0.013
actin cytoskeleton organization	GO:0030036	220	0.013
divalent inorganic cation homeostasis	GO:0072507	138	0.013
regulation of excitatory postsynaptic membrane potential	GO:0060079	41	0.013
transmembrane receptor protein tyrosine kinase signaling pathway	GO:0007169	247	0.013
epithelial to mesenchymal transition	GO:0001837	47	0.013
cellular response to lipid	GO:0071396	145	0.013
epithelial cell development	GO:0002064	159	0.013
ossification	GO:0001503	216	0.013
intrahepatic bile duct development	GO:0035622	2	0.013
lung morphogenesis	GO:0060425	50	0.013
regulation of proteolysis involved in cellular protein catabolic process	GO:1903050	56	0.013
embryonic camera type eye development	GO:0031076	36	0.013
muscle system process	GO:0003012	141	0.012
determination of heart left right asymmetry	GO:0061371	48	0.012
regulation of mesenchymal cell apoptotic process involved in nephron morphogenesis	GO:0072039	4	0.012
negative regulation of cellular protein metabolic process	GO:0032269	247	0.012
g protein coupled receptor signaling pathway coupled to cyclic nucleotide second messenger	GO:0007187	55	0.012
organelle localization	GO:0051640	179	0.012
kidney epithelium development	GO:0072073	121	0.012
regulation of protein processing	GO:0070613	96	0.012
regulation of embryonic development	GO:0045995	71	0.012
regulation of cell motility	GO:2000145	236	0.012
potassium ion transport	GO:0006813	52	0.012
germ line sex determination	GO:0018992	3	0.012
regulation of lymphocyte differentiation	GO:0045619	107	0.012
embryonic skeletal system morphogenesis	GO:0048704	91	0.012
cellular macromolecule catabolic process	GO:0044265	206	0.012
nucleotide catabolic process	GO:0009166	217	0.012
cellular protein catabolic process	GO:0044257	155	0.012
establishment of organelle localization	GO:0051656	122	0.012
response to epidermal growth factor	GO:0070849	4	0.012
cellular glucose homeostasis	GO:0001678	52	0.012
extracellular structure organization	GO:0043062	148	0.012
digestive tract morphogenesis	GO:0048546	147	0.012
male sex differentiation	GO:0046661	109	0.012
determination of left right symmetry	GO:0007368	80	0.012
acid secretion	GO:0046717	33	0.012
negative regulation of phosphate metabolic process	GO:0045936	184	0.012
digestive tract development	GO:0048565	190	0.012
insulin secretion	GO:0030073	89	0.012
central nervous system neuron differentiation	GO:0021953	162	0.012
morphogenesis of embryonic epithelium	GO:0016331	159	0.012
positive regulation of apoptotic process	GO:0043065	217	0.012
fertilization	GO:0009566	127	0.012
regulation of ossification	GO:0030278	112	0.011
regulation of muscle system process	GO:0090257	80	0.011
regulation of chloride transport	GO:2001225	2	0.011
angiogenesis	GO:0001525	201	0.011
response to acid chemical	GO:0001101	111	0.011
regionalization	GO:0003002	337	0.011
germ cell development	GO:0007281	185	0.011
positive regulation of gliogenesis	GO:0014015	27	0.011
negative regulation of lymphocyte differentiation	GO:0045620	32	0.011
regulation of vascular smooth muscle contraction	GO:0003056	1	0.011
regulation of glutamate secretion	GO:0014048	3	0.011
purine ribonucleoside monophosphate metabolic process	GO:0009167	80	0.011
response to peptide hormone	GO:0043434	127	0.011
circadian regulation of gene expression	GO:0032922	48	0.011
adenylate cyclase activating g protein coupled receptor signaling pathway	GO:0007189	30	0.011
pancreas development	GO:0031016	57	0.011
positive regulation of gamma aminobutyric acid secretion	GO:0014054	2	0.011
nucleocytoplasmic transport	GO:0006913	139	0.011
atp metabolic process	GO:0046034	75	0.011
gamma aminobutyric acid transport	GO:0015812	7	0.011
cytoplasmic transport	GO:0016482	234	0.011
regulation of hormone secretion	GO:0046883	88	0.011
amino acid transmembrane transport	GO:0003333	37	0.011
activation of adenylate cyclase activity	GO:0007190	4	0.011
endocardial cell differentiation	GO:0060956	4	0.011
ribonucleoside triphosphate metabolic process	GO:0009199	220	0.011
negative regulation of immune system process	GO:0002683	209	0.011
regulation of mast cell activation	GO:0033003	21	0.011
positive regulation of secondary heart field cardioblast proliferation	GO:0072513	4	0.011
response to amino acid	GO:0043200	37	0.011
cellular amine metabolic process	GO:0044106	44	0.011
apoptotic signaling pathway	GO:0097190	306	0.011
protein modification by small protein conjugation	GO:0032446	187	0.011
cyclic purine nucleotide metabolic process	GO:0052652	43	0.011
hepaticobiliary system development	GO:0061008	67	0.011
purine nucleoside triphosphate metabolic process	GO:0009144	226	0.010
limb morphogenesis	GO:0035108	149	0.010
septum primum development	GO:0003284	4	0.010
regulation of cytoplasmic transport	GO:1903649	112	0.010
dorsal ventral axon guidance	GO:0033563	3	0.010
dendritic spine development	GO:0060996	30	0.010
purine nucleoside monophosphate catabolic process	GO:0009128	58	0.010
covalent chromatin modification	GO:0016569	163	0.010
aromatic compound catabolic process	GO:0019439	286	0.010
regulation of neuron projection development	GO:0010975	169	0.010
asymmetric stem cell division	GO:0098722	3	0.010
positive regulation of ossification	GO:0045778	47	0.010
calcium ion homeostasis	GO:0055074	127	0.010
myeloid cell differentiation	GO:0030099	233	0.010
purine ribonucleoside monophosphate catabolic process	GO:0009169	57	0.010
regulation of proteasomal protein catabolic process	GO:0061136	46	0.010
excretion	GO:0007588	22	0.010
t cell activation	GO:0042110	289	0.010
response to oxidative stress	GO:0006979	123	0.010
multicellular organismal signaling	GO:0035637	91	0.010
regulation of stem cell differentiation	GO:2000736	50	0.010
intraciliary transport	GO:0042073	9	0.010

Wdr78 disease predictions

Disease predictions are made from cross-annotation of human disease genes to the identified functional analogs in mouse and predicted with the mouse functional network.

Disease	DO term ID	Probability
sensory system disease	DOID:0050155	0.045
eye and adnexa disease	DOID:1492	0.045
disease of anatomical entity	DOID:7	0.045
eye disease	DOID:5614	0.045
retinal degeneration	DOID:8466	0.045
retinal disease	DOID:5679	0.045
nervous system disease	DOID:863	0.045
primary ciliary dyskinesia	DOID:9562	0.037
organ system cancer	DOID:0050686	0.022
disease of cellular proliferation	DOID:14566	0.022
cancer	DOID:162	0.022
central nervous system disease	DOID:331	0.012
hematologic cancer	DOID:2531	0.011
immune system cancer	DOID:0060083	0.011

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