IMP: Integrative Multi-species Prediction

Mus musculus

0 known processes

Cldn16

claudin 16

(Aliases: claudin-16,PCLN1)

Entrez: 114141
Ensembl: ENSMUSG00000038148
UniProtKB: Q925N4
UniProtKB: Q14BW2

Process Predictions
Disease Predictions

Cldn16 biological process predictions

Show only novel predictionsHighlight processes of functional analogs

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Biological process	GO term ID	Process size	Probability	Func Analog Org
hypotonic response	GO:0006971	3	0.978
renal system process	GO:0003014	48	0.610
inorganic ion transmembrane transport	GO:0098660	234	0.607
ion transmembrane transport	GO:0034220	361	0.520
transmembrane transport	GO:0055085	412	0.451
developmental maturation	GO:0021700	193	0.442
cellular hypotonic response	GO:0071476	3	0.416
inorganic cation transmembrane transport	GO:0098662	207	0.410
cation transmembrane transport	GO:0098655	266	0.403
detection of chemical stimulus involved in sensory perception	GO:0050907	10	0.403
cation transport	GO:0006812	399	0.374
hyperosmotic response	GO:0006972	4	0.365
urinary bladder smooth muscle contraction	GO:0014832	5	0.319
smooth muscle contraction involved in micturition	GO:0060083	3	0.310
muscle contraction	GO:0006936	101	0.279
nitrogen compound transport	GO:0071705	271	0.275
response to ph	GO:0009268	14	0.209
vasopressin secretion	GO:0030103	1	0.202
urinary tract smooth muscle contraction	GO:0014848	6	0.173
axonogenesis	GO:0007409	274	0.153
response to nutrient levels	GO:0031667	109	0.149
regulation of cellular component size	GO:0032535	121	0.147
peptide transport	GO:0015833	133	0.141
cell junction assembly	GO:0034329	52	0.140	Mouse
regulation of anatomical structure size	GO:0090066	178	0.133
muscle system process	GO:0003012	141	0.133
positive regulation of ion transmembrane transport	GO:0034767	24	0.132
regulation of cell size	GO:0008361	72	0.127
developmental growth involved in morphogenesis	GO:0060560	138	0.125
positive regulation of axon extension	GO:0045773	20	0.123
carnitine transport	GO:0015879	3	0.122
divalent inorganic cation transport	GO:0072511	178	0.122
regulation of cell morphogenesis involved in differentiation	GO:0010769	151	0.120
cellular homeostasis	GO:0019725	240	0.115
inflammatory response	GO:0006954	244	0.115
osmosensory signaling pathway	GO:0007231	1	0.109
detection of stimulus	GO:0051606	84	0.107
regulation of ion transmembrane transport	GO:0034765	119	0.107
skin development	GO:0043588	220	0.106	Mouse
positive regulation of cell projection organization	GO:0031346	95	0.103
calcium ion transmembrane transport	GO:0070588	85	0.103
neuron projection extension	GO:1990138	64	0.100
multicellular organismal homeostasis	GO:0048871	164	0.098
urate transport	GO:0015747	1	0.098
acute inflammatory response	GO:0002526	41	0.098
cellular chemical homeostasis	GO:0055082	215	0.091
regulation of metal ion transport	GO:0010959	106	0.091
response to extracellular stimulus	GO:0009991	127	0.088
sensory perception	GO:0007600	245	0.087
amino acid betaine transport	GO:0015838	3	0.084
developmental cell growth	GO:0048588	84	0.084
excretion	GO:0007588	22	0.082
positive regulation of neuron projection development	GO:0010976	79	0.082
regulation of axon extension	GO:0030516	43	0.081
regulation of ion transport	GO:0043269	215	0.080
positive regulation of ion transport	GO:0043270	65	0.079
positive regulation of neuron differentiation	GO:0045666	141	0.078
regulation of hormone levels	GO:0010817	211	0.077
positive regulation of cell development	GO:0010720	237	0.077
regulation of neuron differentiation	GO:0045664	281	0.076
positive regulation of calcium ion transport	GO:0051928	27	0.075
cation homeostasis	GO:0055080	212	0.073
regulation of response to osmotic stress	GO:0047484	3	0.072
divalent metal ion transport	GO:0070838	172	0.072
cell cell junction assembly	GO:0007043	27	0.071	Mouse
sensory perception of chemical stimulus	GO:0007606	51	0.070
detection of stimulus involved in sensory perception	GO:0050906	44	0.070
carnitine transmembrane transport	GO:1902603	3	0.069
hormone secretion	GO:0046879	128	0.068
regulation of extent of cell growth	GO:0061387	52	0.068
response to osmotic stress	GO:0006970	21	0.066
amino acid transmembrane transport	GO:0003333	37	0.066
cell cell junction organization	GO:0045216	72	0.065	Mouse
purine containing compound metabolic process	GO:0072521	311	0.064
micturition	GO:0060073	6	0.060
hair cycle phase	GO:0044851	16	0.060
sensory perception of mechanical stimulus	GO:0050954	107	0.058
cellular divalent inorganic cation homeostasis	GO:0072503	127	0.057
cytoplasmic transport	GO:0016482	234	0.057
regulation of neuron projection development	GO:0010975	169	0.056
cellular ion homeostasis	GO:0006873	165	0.053
smooth muscle contraction	GO:0006939	44	0.052
diet induced thermogenesis	GO:0002024	7	0.051
cell growth	GO:0016049	130	0.049
fever generation	GO:0001660	7	0.047
chemotaxis	GO:0006935	247	0.046
cellular metal ion homeostasis	GO:0006875	151	0.046
circulatory system process	GO:0003013	197	0.045
regulation of homeostatic process	GO:0032844	182	0.045
carnitine metabolic process	GO:0009437	7	0.045
cellular ketone metabolic process	GO:0042180	84	0.044
response to pain	GO:0048265	26	0.043
purine nucleotide metabolic process	GO:0006163	302	0.043
cell junction organization	GO:0034330	77	0.042	Mouse
regulation of cell projection organization	GO:0031344	206	0.042
anion transmembrane transport	GO:0098656	71	0.042
regulation of renin secretion into blood stream	GO:1900133	4	0.041
nucleotide metabolic process	GO:0009117	332	0.040
multicellular organismal response to stress	GO:0033555	62	0.039
cellular response to osmotic stress	GO:0071470	7	0.037
hair follicle development	GO:0001942	85	0.037
hair cycle	GO:0042633	90	0.036
heat generation	GO:0031649	13	0.036
calcium ion transport	GO:0006816	159	0.036
positive regulation of cell morphogenesis involved in differentiation	GO:0010770	72	0.035
muscle tissue development	GO:0060537	308	0.034
regulation of multicellular organismal metabolic process	GO:0044246	14	0.034
positive regulation of cytosolic calcium ion concentration	GO:0007204	65	0.034
nucleoside phosphate metabolic process	GO:0006753	338	0.033
biological phase	GO:0044848	20	0.033
temperature homeostasis	GO:0001659	26	0.033
cytosolic calcium ion homeostasis	GO:0051480	70	0.033
positive regulation of transferase activity	GO:0051347	167	0.032
cellular response to growth factor stimulus	GO:0071363	197	0.032
regulation of cellular ketone metabolic process	GO:0010565	66	0.032
small gtpase mediated signal transduction	GO:0007264	97	0.032
anatomical structure maturation	GO:0071695	49	0.031
blood circulation	GO:0008015	195	0.031
cellular amine metabolic process	GO:0044106	44	0.031
sodium ion transport	GO:0006814	73	0.031
inorganic anion transport	GO:0015698	43	0.031
transmission of nerve impulse	GO:0019226	76	0.031	Mouse
amine metabolic process	GO:0009308	45	0.030
peptide secretion	GO:0002790	114	0.030
cytosolic calcium ion transport	GO:0060401	48	0.029
cellular response to abiotic stimulus	GO:0071214	56	0.029
cellular amino acid metabolic process	GO:0006520	103	0.029
response to organonitrogen compound	GO:0010243	246	0.029
detection of chemical stimulus	GO:0009593	16	0.029
regulation of cellular amine metabolic process	GO:0033238	20	0.029
regulation of heart contraction	GO:0008016	77	0.028
regulation of cellular amino acid metabolic process	GO:0006521	5	0.028
molting cycle	GO:0042303	90	0.027
divalent inorganic cation homeostasis	GO:0072507	138	0.027
positive regulation of cellular amine metabolic process	GO:0033240	5	0.027
positive regulation of growth	GO:0045927	104	0.027
leukocyte differentiation	GO:0002521	342	0.027
regulation of lymphocyte activation	GO:0051249	240	0.026
protein tetramerization	GO:0051262	23	0.026
amino acid transport	GO:0006865	61	0.026
cellular calcium ion homeostasis	GO:0006874	119	0.026
hydrogen ion transmembrane transport	GO:1902600	25	0.026
regulation of membrane potential	GO:0042391	192	0.026	Mouse
striated muscle tissue development	GO:0014706	293	0.025
ribose phosphate metabolic process	GO:0019693	291	0.025
response to dietary excess	GO:0002021	18	0.025
renal system development	GO:0072001	225	0.024
positive regulation of cellular amino acid metabolic process	GO:0045764	3	0.024
amino acid betaine metabolic process	GO:0006577	7	0.024
regulation of transferase activity	GO:0051338	263	0.023
organic cyclic compound catabolic process	GO:1901361	295	0.023
g protein coupled receptor signaling pathway	GO:0007186	243	0.023
calcium ion homeostasis	GO:0055074	127	0.023
cellular nitrogen compound catabolic process	GO:0044270	280	0.023
regulation of kinase activity	GO:0043549	249	0.022
regulation of purine nucleotide metabolic process	GO:1900542	169	0.022
response to calcium ion	GO:0051592	20	0.022
heterocycle catabolic process	GO:0046700	280	0.021
ribonucleotide metabolic process	GO:0009259	291	0.021
stem cell differentiation	GO:0048863	268	0.021
neuronal action potential	GO:0019228	54	0.021	Mouse
regulation of calcium ion import	GO:0090279	10	0.020
regulation of cell motility	GO:2000145	236	0.020
heart process	GO:0003015	94	0.020
response to heat	GO:0009408	27	0.020
modified amino acid transport	GO:0072337	5	0.020
regulation of cell activation	GO:0050865	289	0.020
mapk cascade	GO:0000165	281	0.020
epidermis development	GO:0008544	187	0.019
proton transport	GO:0015992	35	0.019
response to growth factor	GO:0070848	198	0.019
muscle cell development	GO:0055001	133	0.019
positive regulation of nervous system development	GO:0051962	221	0.019
anion transport	GO:0006820	177	0.019
detection of chemical stimulus involved in sensory perception of taste	GO:0050912	3	0.019
fat cell differentiation	GO:0045444	160	0.019
glycerolipid metabolic process	GO:0046486	122	0.018
ribonucleoside metabolic process	GO:0009119	245	0.018
ossification	GO:0001503	216	0.018
regulation of cell growth	GO:0001558	91	0.018
regulation of leukocyte differentiation	GO:1902105	159	0.018
nucleobase containing small molecule metabolic process	GO:0055086	352	0.018
cellular response to nutrient levels	GO:0031669	64	0.018
regulation of cell cycle	GO:0051726	281	0.017
regulation of blood vessel size	GO:0050880	56	0.017
multicellular organismal signaling	GO:0035637	91	0.017	Mouse
locomotory behavior	GO:0007626	195	0.017
ras protein signal transduction	GO:0007265	77	0.017
regulation of cellular catabolic process	GO:0031329	242	0.017
calcium ion transport into cytosol	GO:0060402	48	0.017
protein oligomerization	GO:0051259	67	0.017
regulation of lipid metabolic process	GO:0019216	118	0.017
epithelial cell proliferation	GO:0050673	174	0.016
cellular lipid metabolic process	GO:0044255	323	0.016
regulation of response to wounding	GO:1903034	189	0.016
cell adhesion	GO:0007155	329	0.016	Mouse
response to inorganic substance	GO:0010035	96	0.016
cellular response to carbohydrate stimulus	GO:0071322	50	0.016
cardiac muscle tissue development	GO:0048738	130	0.016
nucleoside phosphate biosynthetic process	GO:1901293	79	0.016
inter male aggressive behavior	GO:0002121	3	0.016
muscle fiber development	GO:0048747	76	0.016
protein modification by small protein conjugation or removal	GO:0070647	207	0.016
positive regulation of cell growth	GO:0030307	33	0.015
regulation of secretion	GO:0051046	274	0.015
epithelial cell development	GO:0002064	159	0.015
multicellular organismal metabolic process	GO:0044236	28	0.015
neuron projection guidance	GO:0097485	141	0.015
organic hydroxy compound metabolic process	GO:1901615	203	0.015
organonitrogen compound biosynthetic process	GO:1901566	192	0.015
cellular response to monosaccharide stimulus	GO:0071326	47	0.015
sodium ion transmembrane transport	GO:0035725	49	0.015
regulation of organelle organization	GO:0033043	289	0.015
regulation of blood pressure	GO:0008217	93	0.015
regulation of secretion by cell	GO:1903530	249	0.015
glycosyl compound catabolic process	GO:1901658	206	0.014
regulation of multi organism process	GO:0043900	111	0.014
t cell activation	GO:0042110	289	0.014
myeloid leukocyte migration	GO:0097529	57	0.014
acute phase response	GO:0006953	10	0.014
cognition	GO:0050890	149	0.014
stem cell development	GO:0048864	219	0.014
homeostasis of number of cells	GO:0048872	210	0.014
aromatic compound catabolic process	GO:0019439	286	0.014
response to metal ion	GO:0010038	47	0.014
regulation of mitotic cell cycle	GO:0007346	126	0.014
positive regulation of protein phosphorylation	GO:0001934	242	0.014
positive regulation of cytokine production	GO:0001819	174	0.014
intracellular protein transport	GO:0006886	204	0.014
glycosyl compound metabolic process	GO:1901657	246	0.014
embryonic organ morphogenesis	GO:0048562	276	0.014
cardiac muscle contraction	GO:0060048	32	0.014
gliogenesis	GO:0042063	141	0.014
amide transport	GO:0042886	138	0.013
purine nucleoside triphosphate catabolic process	GO:0009146	203	0.013
organic hydroxy compound transport	GO:0015850	93	0.013
regulation of cell migration	GO:0030334	219	0.013
purine ribonucleotide metabolic process	GO:0009150	290	0.013
single fertilization	GO:0007338	82	0.013
purine containing compound catabolic process	GO:0072523	213	0.013
regulation of cytokine production	GO:0001817	266	0.013
inorganic anion transmembrane transport	GO:0098661	29	0.013
cellular response to prostaglandin stimulus	GO:0071379	2	0.013
negative regulation of protein modification process	GO:0031400	163	0.013
response to acid chemical	GO:0001101	111	0.013
negative regulation of cellular amino acid metabolic process	GO:0045763	0	0.013
organophosphate biosynthetic process	GO:0090407	122	0.013
regulation of transmembrane transport	GO:0034762	128	0.013
small molecule biosynthetic process	GO:0044283	132	0.013
bone development	GO:0060348	120	0.013
midgut development	GO:0007494	4	0.013
purine ribonucleoside metabolic process	GO:0046128	241	0.013
c21 steroid hormone biosynthetic process	GO:0006700	3	0.013
macromolecule catabolic process	GO:0009057	281	0.013
heart contraction	GO:0060047	93	0.013
positive regulation of thymocyte migration	GO:2000412	2	0.013
positive regulation of cellular catabolic process	GO:0031331	148	0.012
ensheathment of neurons	GO:0007272	76	0.012	Mouse
cellular response to starvation	GO:0009267	57	0.012
nucleoside triphosphate metabolic process	GO:0009141	230	0.012
negative regulation of hormone metabolic process	GO:0032351	4	0.012
response to vitamin d	GO:0033280	3	0.012
purine ribonucleoside triphosphate metabolic process	GO:0009205	220	0.012
mesenchyme development	GO:0060485	152	0.012
regulation of protein kinase activity	GO:0045859	232	0.012
tissue homeostasis	GO:0001894	115	0.012
kidney development	GO:0001822	213	0.012
cellular alcohol metabolic process	GO:0044107	3	0.012
regulation of blood circulation	GO:1903522	93	0.012
multicellular organism growth	GO:0035264	161	0.012
regulation of system process	GO:0044057	200	0.012
negative regulation of cellular component organization	GO:0051129	194	0.012
digestive system development	GO:0055123	200	0.012
positive regulation of vasoconstriction	GO:0045907	4	0.012
androgen biosynthetic process	GO:0006702	4	0.012
neuron migration	GO:0001764	122	0.012
transmembrane receptor protein tyrosine kinase signaling pathway	GO:0007169	247	0.012
organic acid transport	GO:0015849	101	0.012
carbohydrate homeostasis	GO:0033500	128	0.012
transmembrane receptor protein serine threonine kinase signaling pathway	GO:0007178	194	0.012
single organism cell adhesion	GO:0098602	156	0.012
regulation of cellular response to stress	GO:0080135	159	0.011
synaptic transmission	GO:0007268	329	0.011
cellular response to heat	GO:0034605	15	0.011
positive regulation of protein kinase activity	GO:0045860	144	0.011
fertilization	GO:0009566	127	0.011
cellular protein complex assembly	GO:0043623	116	0.011
heart morphogenesis	GO:0003007	178	0.011
av node cell to bundle of his cell communication	GO:0086067	2	0.011
membrane organization	GO:0061024	245	0.011
carbohydrate derivative catabolic process	GO:1901136	231	0.011
regulation of actin filament based process	GO:0032970	99	0.011
monovalent inorganic cation homeostasis	GO:0055067	33	0.011
rho protein signal transduction	GO:0007266	32	0.011
regulation of cellular component biogenesis	GO:0044087	181	0.011
purine ribonucleoside triphosphate catabolic process	GO:0009207	199	0.010
regulation of cellular response to growth factor stimulus	GO:0090287	82	0.010
respiratory system development	GO:0060541	190	0.010
placenta development	GO:0001890	140	0.010
gland development	GO:0048732	330	0.010
regulation of action potential	GO:0098900	4	0.010
leukocyte chemotaxis	GO:0030595	69	0.010
neurotransmitter transport	GO:0006836	76	0.010
ribonucleoside triphosphate metabolic process	GO:0009199	220	0.010
ribonucleoside catabolic process	GO:0042454	206	0.010
striated muscle cell development	GO:0055002	125	0.010
organic anion transport	GO:0015711	137	0.010
ammonia homeostasis	GO:0097272	1	0.010
response to light stimulus	GO:0009416	135	0.010
regulation of nucleotide metabolic process	GO:0006140	169	0.010

Cldn16 disease predictions

Disease predictions are made from cross-annotation of human disease genes to the identified functional analogs in mouse and predicted with the mouse functional network.

	Disease	DO term ID	Size	Probability	Func Analog Org
	disease of metabolism	DOID:0014667	0	0.013

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