IMP: Integrative Multi-species Prediction

Mus musculus

0 known processes

Traf1

TNF receptor-associated factor 1

(Aliases: 4732496E14Rik)

Entrez: 22029
Ensembl: ENSMUSG00000026875
UniProtKB: P39428

Process Predictions
Disease Predictions

Traf1 biological process predictions

Show only novel predictionsHighlight processes of functional analogs

Filter by process size:

Biological process	GO term ID	Process size	Probability	Func Analog Org
regulation of defense response	GO:0031347	233	0.892	Mouse
cytokine production	GO:0001816	319	0.809	Mouse
cd4 positive alpha beta t cell differentiation involved in immune response	GO:0002294	28	0.712
positive regulation of t cell activation	GO:0050870	101	0.657	Mouse
t cell differentiation	GO:0030217	174	0.634
regulation of innate immune response	GO:0045088	91	0.596	Mouse
positive regulation of lymphocyte activation	GO:0051251	140	0.595	Mouse
t helper cell differentiation	GO:0042093	28	0.583
adaptive immune response	GO:0002250	155	0.580	Mouse
innate immune response	GO:0045087	157	0.563	Mouse
alpha beta t cell activation involved in immune response	GO:0002287	31	0.551
adaptive immune response based on somatic recombination of immune receptors built from immunoglobulin superfamily domains	GO:0002460	145	0.529	Mouse
defense response to other organism	GO:0098542	197	0.525	Mouse
t cell proliferation	GO:0042098	120	0.515	Mouse
regulation of cytokine production	GO:0001817	266	0.483	Mouse
response to molecule of bacterial origin	GO:0002237	143	0.476	Mouse
regulation of establishment of protein localization	GO:0070201	181	0.454	Mouse
positive regulation of cytokine production	GO:0001819	174	0.429	Mouse
leukocyte differentiation	GO:0002521	342	0.425	Mouse
regulation of inflammatory response	GO:0050727	147	0.404
alpha beta t cell activation	GO:0046631	91	0.383
immune effector process	GO:0002252	321	0.373	Mouse
myeloid leukocyte differentiation	GO:0002573	119	0.368	Mouse
t cell differentiation involved in immune response	GO:0002292	30	0.360
regulation of protein transport	GO:0051223	163	0.358	Mouse
cellular response to cytokine stimulus	GO:0071345	189	0.355	Mouse
cd4 positive alpha beta t cell activation	GO:0035710	45	0.353
cd4 positive alpha beta t cell differentiation	GO:0043367	41	0.353
leukocyte mediated immunity	GO:0002443	174	0.346
cytokine metabolic process	GO:0042107	71	0.345	Mouse
immunoglobulin mediated immune response	GO:0016064	69	0.313
interleukin 12 secretion	GO:0072610	3	0.302
lymphocyte differentiation	GO:0030098	242	0.301
positive regulation of inflammatory response	GO:0050729	47	0.244
regulation of protein localization	GO:0032880	231	0.241	Mouse
interleukin 10 secretion	GO:0072608	4	0.238
regulation of t cell activation	GO:0050863	170	0.237	Mouse
positive regulation of innate immune response	GO:0045089	80	0.233	Mouse
cellular response to lipopolysaccharide	GO:0071222	77	0.228	Mouse
negative regulation of immune system process	GO:0002683	209	0.227
lymphocyte proliferation	GO:0046651	164	0.223	Mouse
positive regulation of secretion	GO:0051047	130	0.213
positive t cell selection	GO:0043368	23	0.212
alpha beta t cell differentiation	GO:0046632	69	0.210
production of molecular mediator of immune response	GO:0002440	103	0.207	Mouse
protein secretion	GO:0009306	111	0.205	Mouse
negative regulation of cytokine production	GO:0001818	84	0.201
cytokine secretion	GO:0050663	72	0.196
regulation of leukocyte mediated immunity	GO:0002703	104	0.190
leukocyte activation involved in immune response	GO:0002366	126	0.189
t cell activation	GO:0042110	289	0.186	Mouse
leukocyte proliferation	GO:0070661	172	0.184	Mouse
inflammatory response	GO:0006954	244	0.174
i kappab kinase nf kappab signaling	GO:0007249	85	0.171	Mouse
regulation of leukocyte proliferation	GO:0070663	121	0.164	Mouse
positive regulation of lymphocyte proliferation	GO:0050671	70	0.161	Mouse
t helper 1 type immune response	GO:0042088	25	0.161	Mouse
positive regulation of defense response	GO:0031349	124	0.160	Mouse
positive regulation of hydrolase activity	GO:0051345	148	0.155
negative regulation of protein transport	GO:0051224	46	0.153
positive regulation of immune effector process	GO:0002699	107	0.150
t cell activation involved in immune response	GO:0002286	43	0.148
negative regulation of protein metabolic process	GO:0051248	282	0.147
defense response to gram positive bacterium	GO:0050830	50	0.146
positive regulation of t cell proliferation	GO:0042102	52	0.139	Mouse
extrinsic apoptotic signaling pathway	GO:0097191	126	0.139	Human
immune response activating signal transduction	GO:0002757	116	0.137	Mouse
regulation of membrane potential	GO:0042391	192	0.134
regulation of hydrolase activity	GO:0051336	246	0.130
regulation of lymphocyte proliferation	GO:0050670	117	0.129	Mouse
positive regulation of leukocyte proliferation	GO:0070665	73	0.124	Mouse
protein modification by small protein conjugation	GO:0032446	187	0.123	Mouse
somatic diversification of immune receptors via germline recombination within a single locus	GO:0002562	51	0.123
regulation of interleukin 10 secretion	GO:2001179	4	0.121
dna recombination	GO:0006310	92	0.121
response to lipopolysaccharide	GO:0032496	128	0.120	Mouse
regulation of alpha beta t cell activation	GO:0046634	53	0.120
regulation of interleukin 2 biosynthetic process	GO:0045076	13	0.116
purine ribonucleoside metabolic process	GO:0046128	241	0.116
positive regulation of cytokine biosynthetic process	GO:0042108	40	0.112	Mouse
regulation of protein secretion	GO:0050708	82	0.111	Mouse
regulation of cell activation	GO:0050865	289	0.111	Mouse
regulation of adaptive immune response based on somatic recombination of immune receptors built from immunoglobulin superfamily domains	GO:0002822	87	0.110
interleukin 2 production	GO:0032623	33	0.109
myeloid cell differentiation	GO:0030099	233	0.108	Mouse
regulation of t cell proliferation	GO:0042129	92	0.107	Mouse
activation of immune response	GO:0002253	138	0.107	Mouse
gliogenesis	GO:0042063	141	0.107
regulation of secretion	GO:0051046	274	0.107	Mouse
regulation of cytokine secretion	GO:0050707	61	0.105
glycosyl compound metabolic process	GO:1901657	246	0.105
cell activation involved in immune response	GO:0002263	126	0.103
positive regulation of monocyte chemotaxis	GO:0090026	2	0.103
transmembrane receptor protein tyrosine kinase signaling pathway	GO:0007169	247	0.102
negative regulation of protein secretion	GO:0050709	20	0.102
cell adhesion	GO:0007155	329	0.101
myeloid leukocyte activation	GO:0002274	83	0.101	Mouse
ras protein signal transduction	GO:0007265	77	0.101
regulation of lymphocyte activation	GO:0051249	240	0.100	Mouse
positive regulation of programmed cell death	GO:0043068	218	0.100
purine containing compound metabolic process	GO:0072521	311	0.099
cation homeostasis	GO:0055080	212	0.099
gland development	GO:0048732	330	0.098
positive regulation of protein secretion	GO:0050714	52	0.096
regulation of secretion by cell	GO:1903530	249	0.096	Mouse
regulation of homeostatic process	GO:0032844	182	0.096
negative regulation of defense response	GO:0031348	77	0.095
somatic cell dna recombination	GO:0016444	51	0.094
regulation of response to wounding	GO:1903034	189	0.093
lymphocyte mediated immunity	GO:0002449	139	0.093
cellular response to biotic stimulus	GO:0071216	92	0.092	Mouse
t helper 1 cell differentiation	GO:0045063	13	0.091
cdc42 protein signal transduction	GO:0032488	0	0.090
regulation of proteolysis	GO:0030162	164	0.090	Mouse
g protein coupled receptor signaling pathway	GO:0007186	243	0.088
nucleoside metabolic process	GO:0009116	246	0.087
cellular homeostasis	GO:0019725	240	0.087
alpha beta t cell differentiation involved in immune response	GO:0002293	30	0.086
immunoglobulin production	GO:0002377	73	0.086	Mouse
regulation of interleukin 2 production	GO:0032663	28	0.085
regulation of t cell differentiation	GO:0045580	83	0.083
cytokine biosynthetic process	GO:0042089	68	0.083	Mouse
negative regulation of intracellular signal transduction	GO:1902532	167	0.082
positive regulation of leukocyte mediated cytotoxicity	GO:0001912	31	0.081
protein localization to organelle	GO:0033365	185	0.080
negative regulation of secretion	GO:0051048	61	0.080
nucleotide metabolic process	GO:0009117	332	0.080
defense response to virus	GO:0051607	68	0.079	Mouse
purine nucleotide metabolic process	GO:0006163	302	0.078
positive regulation of purine nucleotide metabolic process	GO:1900544	114	0.078
negative regulation of secretion by cell	GO:1903531	54	0.078
purine ribonucleotide metabolic process	GO:0009150	290	0.078
dephosphorylation	GO:0016311	129	0.077
regulation of leukocyte differentiation	GO:1902105	159	0.077
carbohydrate derivative biosynthetic process	GO:1901137	183	0.077
positive regulation of nucleotide metabolic process	GO:0045981	114	0.077
glial cell differentiation	GO:0010001	131	0.076
apoptotic signaling pathway	GO:0097190	306	0.075	Human
positive regulation of leukocyte differentiation	GO:1902107	86	0.075
positive regulation of mapk cascade	GO:0043410	170	0.074
interleukin 2 biosynthetic process	GO:0042094	15	0.072
cellular amino acid metabolic process	GO:0006520	103	0.072
b cell mediated immunity	GO:0019724	71	0.072
ribonucleoside triphosphate metabolic process	GO:0009199	220	0.071
regulation of kinase activity	GO:0043549	249	0.071
negative regulation of cellular protein metabolic process	GO:0032269	247	0.071
homeostasis of number of cells	GO:0048872	210	0.068
positive regulation of apoptotic process	GO:0043065	217	0.066
positive regulation of t helper 1 cell differentiation	GO:0045627	4	0.066
ribose phosphate metabolic process	GO:0019693	291	0.065
purine nucleoside metabolic process	GO:0042278	241	0.065
ribonucleotide metabolic process	GO:0009259	291	0.065
regulation of cysteine type endopeptidase activity	GO:2000116	65	0.064
cell chemotaxis	GO:0060326	81	0.064
response to organonitrogen compound	GO:0010243	246	0.063
mature dendritic cell differentiation	GO:0097029	3	0.063
t cell differentiation in thymus	GO:0033077	77	0.061
positive regulation of protein phosphorylation	GO:0001934	242	0.060
regulation of eosinophil migration	GO:2000416	2	0.060
synaptic transmission	GO:0007268	329	0.060
cell type specific apoptotic process	GO:0097285	268	0.060
regulation of peptidase activity	GO:0052547	96	0.059
lymphocyte activation involved in immune response	GO:0002285	93	0.058
regulation of adaptive immune response	GO:0002819	90	0.058
positive regulation of protein transport	GO:0051222	93	0.058
neuron death	GO:0070997	154	0.058
sequestering of calcium ion	GO:0051208	18	0.058
regulation of cysteine type endopeptidase activity involved in apoptotic process	GO:0043281	62	0.057
protein homotrimerization	GO:0070207	4	0.057
positive regulation of protein serine threonine kinase activity	GO:0071902	106	0.057
carbohydrate derivative catabolic process	GO:1901136	231	0.057
positive regulation of cell activation	GO:0050867	158	0.056	Mouse
carbohydrate metabolic process	GO:0005975	230	0.056
regulation of endopeptidase activity	GO:0052548	89	0.055
positive regulation of cell development	GO:0010720	237	0.055
cellular metal ion homeostasis	GO:0006875	151	0.055
divalent inorganic cation homeostasis	GO:0072507	138	0.054
regulation of acute inflammatory response	GO:0002673	27	0.054
thymocyte migration	GO:0072679	2	0.054
interferon gamma production	GO:0032609	67	0.054
nucleoside phosphate metabolic process	GO:0006753	338	0.054
regulation of lymphocyte differentiation	GO:0045619	107	0.054
small gtpase mediated signal transduction	GO:0007264	97	0.054
positive regulation of interferon gamma production	GO:0032729	39	0.054
protein import into nucleus	GO:0006606	95	0.053
positive regulation of production of molecular mediator of immune response	GO:0002702	45	0.053
peptide transport	GO:0015833	133	0.053
negative regulation of molecular function	GO:0044092	258	0.053	Mouse
cellular response to tumor necrosis factor	GO:0071356	21	0.053	Mouse
exocytosis	GO:0006887	121	0.053
positive regulation of cell death	GO:0010942	224	0.052
leukocyte migration	GO:0050900	124	0.052
calcium ion transport	GO:0006816	159	0.052
cation transport	GO:0006812	399	0.052
activation of innate immune response	GO:0002218	56	0.051	Mouse
muscle contraction	GO:0006936	101	0.051
thymic t cell selection	GO:0045061	22	0.051
cell growth	GO:0016049	130	0.051
regulation of transferase activity	GO:0051338	263	0.051
antigen receptor mediated signaling pathway	GO:0050851	64	0.051
positive regulation of thymocyte migration	GO:2000412	2	0.050
regulation of cytokine biosynthetic process	GO:0042035	59	0.050	Mouse
protein import	GO:0017038	101	0.050
negative regulation of apoptotic signaling pathway	GO:2001234	104	0.050
t cell homeostasis	GO:0043029	35	0.050
single organism nuclear import	GO:1902593	95	0.050
epithelial cell proliferation	GO:0050673	174	0.050
negative regulation of phosphorus metabolic process	GO:0010563	184	0.050
positive regulation of t cell differentiation	GO:0045582	52	0.050
multicellular organismal homeostasis	GO:0048871	164	0.050	Mouse
regulation of ion transport	GO:0043269	215	0.050
regulation of alpha beta t cell proliferation	GO:0046640	18	0.050
establishment of protein localization to organelle	GO:0072594	118	0.049
regulation of nucleotide metabolic process	GO:0006140	169	0.049
negative regulation of t cell activation	GO:0050868	65	0.049
cellular ion homeostasis	GO:0006873	165	0.049
regulation of map kinase activity	GO:0043405	120	0.049
leukocyte apoptotic process	GO:0071887	71	0.049
regulation of cellular catabolic process	GO:0031329	242	0.049
nucleotide catabolic process	GO:0009166	217	0.049
positive regulation of gtpase activity	GO:0043547	85	0.049
protein processing	GO:0016485	163	0.049
negative regulation of interleukin 10 secretion	GO:2001180	2	0.048
negative regulation of extrinsic apoptotic signaling pathway	GO:2001237	45	0.048
response to interferon gamma	GO:0034341	34	0.047
mammary gland epithelium development	GO:0061180	65	0.046
glycoprotein biosynthetic process	GO:0009101	89	0.046
type 2 immune response	GO:0042092	23	0.046
purine nucleoside triphosphate catabolic process	GO:0009146	203	0.046
calcium ion homeostasis	GO:0055074	127	0.046
nucleobase containing small molecule metabolic process	GO:0055086	352	0.046
t cell selection	GO:0045058	34	0.045
nucleocytoplasmic transport	GO:0006913	139	0.045
skeletal muscle organ development	GO:0060538	163	0.045
neuron apoptotic process	GO:0051402	142	0.045
positive regulation of secretion by cell	GO:1903532	114	0.044
positive regulation of intracellular transport	GO:0032388	70	0.044
purine nucleoside triphosphate metabolic process	GO:0009144	226	0.044
t cell lineage commitment	GO:0002360	13	0.044
metal ion homeostasis	GO:0055065	189	0.044
purine nucleotide catabolic process	GO:0006195	211	0.044
intrinsic apoptotic signaling pathway in response to dna damage	GO:0008630	57	0.044
ossification	GO:0001503	216	0.044	Mouse
response to peptide	GO:1901652	136	0.044
negative regulation of inflammatory response	GO:0050728	61	0.044
regulation of protein serine threonine kinase activity	GO:0071900	157	0.043
somatic recombination of immunoglobulin gene segments	GO:0016447	42	0.043
regulation of cell adhesion	GO:0030155	154	0.043
response to extracellular stimulus	GO:0009991	127	0.043
positive regulation of cellular catabolic process	GO:0031331	148	0.043
regulation of thymocyte migration	GO:2000410	2	0.043
regulation of purine nucleotide metabolic process	GO:1900542	169	0.043
acute inflammatory response	GO:0002526	41	0.042
protein localization to nucleus	GO:0034504	121	0.042
lymphocyte apoptotic process	GO:0070227	54	0.042
muscle system process	GO:0003012	141	0.042
defecation	GO:0030421	1	0.042
ion transmembrane transport	GO:0034220	361	0.041
cellular response to growth factor stimulus	GO:0071363	197	0.041
positive regulation of eosinophil migration	GO:2000418	2	0.041
regulation of peptide transport	GO:0090087	91	0.040
regulation of organelle organization	GO:0033043	289	0.040
regulation of multi organism process	GO:0043900	111	0.040	Mouse
eosinophil migration	GO:0072677	3	0.039
ribonucleoside metabolic process	GO:0009119	245	0.039
negative regulation of protein processing	GO:0010955	79	0.039
b cell activation	GO:0042113	161	0.039
response to organic cyclic compound	GO:0014070	198	0.039
negative regulation of growth	GO:0045926	99	0.039
t helper 2 cell cytokine production	GO:0035745	4	0.039
positive regulation of protein modification process	GO:0031401	299	0.039
protein modification by small protein conjugation or removal	GO:0070647	207	0.039	Mouse
positive regulation of lymphocyte mediated immunity	GO:0002708	62	0.039
immune response activating cell surface receptor signaling pathway	GO:0002429	72	0.038
negative regulation of leukocyte apoptotic process	GO:2000107	31	0.038
nuclear transport	GO:0051169	139	0.038
protein maturation	GO:0051604	176	0.038
somatic diversification of immunoglobulins involved in immune response	GO:0002208	36	0.038
purine ribonucleoside triphosphate catabolic process	GO:0009207	199	0.038
regulation of b cell activation	GO:0050864	81	0.037
negative regulation of macrophage apoptotic process	GO:2000110	3	0.037
negative regulation of cytokine secretion	GO:0050710	15	0.037
positive regulation of ras gtpase activity	GO:0032320	65	0.037
protein targeting	GO:0006605	143	0.037
glycoprotein metabolic process	GO:0009100	116	0.037
regulation of rho protein signal transduction	GO:0035023	71	0.037
regulation of cellular ketone metabolic process	GO:0010565	66	0.036
b cell activation involved in immune response	GO:0002312	50	0.036
positive regulation of ion transport	GO:0043270	65	0.036
positive regulation of purine nucleotide catabolic process	GO:0033123	88	0.035
regulation of muscle contraction	GO:0006937	49	0.035
organic cyclic compound catabolic process	GO:1901361	295	0.035
immune response regulating signaling pathway	GO:0002764	125	0.035	Mouse
regulation of cellular amine metabolic process	GO:0033238	20	0.035
regulation of mapk cascade	GO:0043408	248	0.035	Mouse
interleukin 12 production	GO:0032615	32	0.035	Mouse
immunoglobulin production involved in immunoglobulin mediated immune response	GO:0002381	43	0.034
regulation of intracellular protein transport	GO:0033157	82	0.034
interferon beta biosynthetic process	GO:0045350	4	0.034
cellular divalent inorganic cation homeostasis	GO:0072503	127	0.034
positive regulation of adaptive immune response based on somatic recombination of immune receptors built from immunoglobulin superfamily domains	GO:0002824	61	0.034
regulation of cellular response to stress	GO:0080135	159	0.034	Mouse
gtp metabolic process	GO:0046039	144	0.034
sensory organ morphogenesis	GO:0090596	242	0.034
cellular ketone metabolic process	GO:0042180	84	0.034
cellular chemical homeostasis	GO:0055082	215	0.034
regulation of lymphocyte mediated immunity	GO:0002706	84	0.034
organonitrogen compound biosynthetic process	GO:1901566	192	0.034
regulation of protein maturation	GO:1903317	96	0.034
regulation of nucleotide catabolic process	GO:0030811	122	0.033
nuclear import	GO:0051170	95	0.033
regulation of interferon gamma production	GO:0032649	57	0.033
regulation of protein targeting	GO:1903533	61	0.033
transmembrane transport	GO:0055085	412	0.033
positive regulation of b cell activation	GO:0050871	49	0.033
alpha beta t cell proliferation	GO:0046633	21	0.033
smooth muscle contraction	GO:0006939	44	0.033
regulation of gtp catabolic process	GO:0033124	113	0.033
regulation of muscle system process	GO:0090257	80	0.033
regulation of reactive oxygen species biosynthetic process	GO:1903426	2	0.033
purine ribonucleoside triphosphate metabolic process	GO:0009205	220	0.033
rho protein signal transduction	GO:0007266	32	0.033
muscle tissue development	GO:0060537	308	0.033
nucleoside catabolic process	GO:0009164	206	0.033
positive regulation of cellular amine metabolic process	GO:0033240	5	0.032
positive regulation of camp mediated signaling	GO:0043950	3	0.032
negative regulation of protein modification process	GO:0031400	163	0.032
sensory perception	GO:0007600	245	0.032
regulation of cell killing	GO:0031341	40	0.032
regulation of cell migration	GO:0030334	219	0.031
positive regulation of alpha beta t cell differentiation	GO:0046638	28	0.031
positive regulation of alpha beta t cell activation	GO:0046635	39	0.031
maintenance of location	GO:0051235	89	0.031
regulation of neuron death	GO:1901214	134	0.031
symbiosis encompassing mutualism through parasitism	GO:0044403	83	0.031
regulation of chemokine secretion	GO:0090196	4	0.031
posttranscriptional regulation of gene expression	GO:0010608	155	0.031
nitrogen compound transport	GO:0071705	271	0.031
t cell mediated immunity	GO:0002456	50	0.031
regulation of interleukin 4 biosynthetic process	GO:0045402	3	0.030
t cell apoptotic process	GO:0070231	39	0.030
cellular response to lipid	GO:0071396	145	0.030	Mouse
cellular amine metabolic process	GO:0044106	44	0.029
regulation of cytoplasmic transport	GO:1903649	112	0.029
regulation of t cell apoptotic process	GO:0070232	28	0.029
actin cytoskeleton organization	GO:0030036	220	0.029
regulation of smooth muscle contraction	GO:0006940	22	0.029
pattern recognition receptor signaling pathway	GO:0002221	47	0.029	Mouse
regulation of tumor necrosis factor production	GO:0032680	49	0.029
regulation of lipid metabolic process	GO:0019216	118	0.029
positive regulation of epithelial cell proliferation	GO:0050679	68	0.029
regulation of cellular component biogenesis	GO:0044087	181	0.028
inorganic cation transmembrane transport	GO:0098662	207	0.028
regulation of system process	GO:0044057	200	0.028
transcription factor import into nucleus	GO:0042991	26	0.028
tissue remodeling	GO:0048771	102	0.028	Mouse
regulation of immunoglobulin production	GO:0002637	42	0.028	Mouse
positive regulation of proteolysis	GO:0045862	85	0.028
positive regulation of gtp catabolic process	GO:0033126	85	0.027
regulation of leukocyte apoptotic process	GO:2000106	56	0.027
positive regulation of lymphocyte differentiation	GO:0045621	61	0.027
cytokine mediated signaling pathway	GO:0019221	115	0.027	Mouse
regulation of protein processing	GO:0070613	96	0.027
activation of mapk activity	GO:0000187	59	0.027
negative regulation of protein maturation	GO:1903318	79	0.027
learning or memory	GO:0007611	148	0.027
purine ribonucleotide catabolic process	GO:0009154	208	0.027
negative regulation of cell activation	GO:0050866	111	0.027
cellular response to external stimulus	GO:0071496	88	0.027
engulfment of apoptotic cell	GO:0043652	3	0.027
response to interleukin 4	GO:0070670	23	0.026
cellular response to dna damage stimulus	GO:0006974	207	0.026
cellular response to molecule of bacterial origin	GO:0071219	83	0.026	Mouse
regulation of anatomical structure size	GO:0090066	178	0.026
positive regulation of transferase activity	GO:0051347	167	0.026
osteoclast differentiation	GO:0030316	62	0.026	Mouse
cellular lipid metabolic process	GO:0044255	323	0.026
regulation of purine nucleotide catabolic process	GO:0033121	122	0.026
dendritic cell differentiation	GO:0097028	26	0.026	Mouse
cellular nitrogen compound catabolic process	GO:0044270	280	0.026
inorganic ion transmembrane transport	GO:0098660	234	0.026
peptidyl amino acid modification	GO:0018193	336	0.026
chemokine production	GO:0032602	34	0.026
reactive oxygen species metabolic process	GO:0072593	84	0.026
regulation of apoptotic signaling pathway	GO:2001233	197	0.026	Human
cellular response to hormone stimulus	GO:0032870	150	0.026
regulation of b cell mediated immunity	GO:0002712	37	0.026
heterocycle catabolic process	GO:0046700	280	0.025
tumor necrosis factor superfamily cytokine production	GO:0071706	51	0.025
positive regulation of t cell receptor signaling pathway	GO:0050862	4	0.025
platelet derived growth factor receptor signaling pathway	GO:0048008	32	0.025
regulation of ras gtpase activity	GO:0032318	88	0.025
cellular response to transforming growth factor beta stimulus	GO:0071560	88	0.025
positive regulation of peptidase activity	GO:0010952	49	0.025
cellular response to prostaglandin d stimulus	GO:0071799	1	0.025
neutrophil migration	GO:1990266	37	0.025
nucleoside triphosphate metabolic process	GO:0009141	230	0.025
t cell migration	GO:0072678	19	0.025
membrane depolarization	GO:0051899	64	0.025
action potential	GO:0001508	78	0.025
positive regulation of intracellular protein transport	GO:0090316	42	0.025
regulation of protein kinase activity	GO:0045859	232	0.025
regulation of cd4 positive alpha beta t cell proliferation	GO:2000561	2	0.025
purine containing compound catabolic process	GO:0072523	213	0.025
positive regulation of rho gtpase activity	GO:0032321	41	0.025
extrinsic apoptotic signaling pathway in absence of ligand	GO:0097192	55	0.024
regulation of endocytosis	GO:0030100	69	0.024
regulation of protein import into nucleus	GO:0042306	52	0.024
positive regulation of cytokine secretion	GO:0050715	41	0.024
microglia differentiation	GO:0014004	2	0.024
regulation of lymphocyte apoptotic process	GO:0070228	41	0.024
regulation of striated muscle cell differentiation	GO:0051153	81	0.024
placenta development	GO:0001890	140	0.024
regulation of immunoglobulin mediated immune response	GO:0002889	37	0.024
protein catabolic process	GO:0030163	221	0.024	Mouse
positive regulation of interleukin 2 biosynthetic process	GO:0045086	8	0.024
cation transmembrane transport	GO:0098655	266	0.024
granulocyte chemotaxis	GO:0071621	39	0.024
mapk cascade	GO:0000165	281	0.024	Mouse
protein oligomerization	GO:0051259	67	0.024
regulation of type 2 immune response	GO:0002828	18	0.023
rhythmic process	GO:0048511	174	0.023
nucleoside phosphate biosynthetic process	GO:1901293	79	0.023
membrane organization	GO:0061024	245	0.023
positive regulation of cell killing	GO:0031343	33	0.023
viral gene expression	GO:0019080	3	0.023
intracellular protein transport	GO:0006886	204	0.023
cell killing	GO:0001906	67	0.023
defense response to protozoan	GO:0042832	25	0.023
innate immune response activating signal transduction	GO:0002758	50	0.023	Mouse
positive regulation of t cell costimulation	GO:2000525	2	0.023
negative regulation of cellular component organization	GO:0051129	194	0.023
regulation of stress activated mapk cascade	GO:0032872	69	0.022	Mouse
ensheathment of neurons	GO:0007272	76	0.022
regulation of asymmetric cell division	GO:0009786	4	0.022
regulation of metal ion transport	GO:0010959	106	0.022
nucleoside triphosphate catabolic process	GO:0009143	205	0.022
protein ubiquitination	GO:0016567	171	0.022	Mouse
regulation of nucleoside metabolic process	GO:0009118	130	0.022
protein kinase b signaling	GO:0043491	74	0.022
protein homooligomerization	GO:0051260	43	0.022
inflammatory response to antigenic stimulus	GO:0002437	30	0.022
sequestering of metal ion	GO:0051238	19	0.022
regulation of calcium ion transport	GO:0051924	69	0.022
divalent metal ion transport	GO:0070838	172	0.022
muscle cell differentiation	GO:0042692	261	0.022
negative regulation of proteolysis	GO:0045861	74	0.022
organic anion transport	GO:0015711	137	0.022
interleukin 6 production	GO:0032635	58	0.022	Mouse
negative regulation of phosphorylation	GO:0042326	166	0.021
immune complex clearance by monocytes and macrophages	GO:0002436	2	0.021
necrotic cell death	GO:0070265	30	0.021	Mouse
response to transforming growth factor beta	GO:0071559	88	0.021
cell recognition	GO:0008037	83	0.021
purine nucleoside catabolic process	GO:0006152	205	0.021
germinal center formation	GO:0002467	16	0.021
regulation of ossification	GO:0030278	112	0.021
regulation of neuron differentiation	GO:0045664	281	0.021
leukocyte mediated cytotoxicity	GO:0001909	62	0.021
amine metabolic process	GO:0009308	45	0.021
interleukin 8 production	GO:0032637	4	0.021
negative regulation of lymphocyte apoptotic process	GO:0070229	24	0.021
multicellular organismal signaling	GO:0035637	91	0.021
reactive oxygen species biosynthetic process	GO:1903409	8	0.021
regulation of epithelial cell proliferation	GO:0050678	141	0.021
aromatic compound catabolic process	GO:0019439	286	0.021
helper t cell chemotaxis	GO:0035704	1	0.021
forebrain development	GO:0030900	302	0.020
cellular defense response	GO:0006968	6	0.020
detection of stimulus	GO:0051606	84	0.020
t cell receptor signaling pathway	GO:0050852	46	0.020
natural killer cell activation	GO:0030101	44	0.020
regulation of nucleocytoplasmic transport	GO:0046822	73	0.020
regulation of extrinsic apoptotic signaling pathway	GO:2001236	77	0.020	Human
germ cell development	GO:0007281	185	0.020
positive regulation of cysteine type endopeptidase activity	GO:2001056	39	0.020
positive regulation of antimicrobial peptide biosynthetic process	GO:0002807	1	0.020
organic hydroxy compound metabolic process	GO:1901615	203	0.020
intrinsic apoptotic signaling pathway	GO:0097193	132	0.019
endocytosis	GO:0006897	168	0.019
ribonucleoside triphosphate catabolic process	GO:0009203	199	0.019
regulation of neuron apoptotic process	GO:0043523	122	0.019
cellular response to peptide hormone stimulus	GO:0071375	92	0.019
regulation of monocyte chemotaxis	GO:0090025	3	0.019
renal system process	GO:0003014	48	0.019
nucleoside phosphate catabolic process	GO:1901292	222	0.019
dna metabolic process	GO:0006259	303	0.019
interleukin 1 production	GO:0032612	31	0.019
regulation of t cell extravasation	GO:2000407	3	0.019
positive regulation of cytoplasmic transport	GO:1903651	40	0.019
microglia development	GO:0014005	2	0.019
developmental cell growth	GO:0048588	84	0.019
translation	GO:0006412	93	0.019
regulation of intracellular transport	GO:0032386	159	0.019
mitochondrion organization	GO:0007005	134	0.019
positive regulation of transcription from rna polymerase ii promoter involved in smooth muscle cell differentiation	GO:2000721	2	0.019

Traf1 disease predictions

Disease predictions are made from cross-annotation of human disease genes to the identified functional analogs in mouse and predicted with the mouse functional network.

Disease	DO term ID	Probability
disease of cellular proliferation	DOID:14566	0.020
disease of anatomical entity	DOID:7	0.020
musculoskeletal system disease	DOID:17	0.020

Loading network...

Network Filters

Minimum relationship confidence:

Maximum number of genes:

Highlight known relationships in gold.

Graphical Options

Adjust edge length:

Adjust node size:

Fixed layout

Black background

Low confidence color:

Med confidence color:

High confidence color:

Hide the legend in the network