Mus musculus

0 known processes

Icos

inducible T-cell co-stimulator

(Aliases: H4,CCLP,AILIM,CRP-1,Ly115)

Icos biological process predictions


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Biological processGO term IDProcess sizeProbabilityFunc Analog Org
natural killer cell inhibitory signaling pathwayGO:000276921.000
positive regulation of defense responseGO:00313491240.999
Mouse
immune response activating cell surface receptor signaling pathwayGO:0002429720.997
Mouse
leukocyte mediated immunityGO:00024431740.997
Mouse
regulation of interleukin 2 biosynthetic processGO:0045076130.996
Mouse
positive regulation of t cell activationGO:00508701010.994
Mouse
immune effector processGO:00022523210.993
Mouse
positive regulation of lymphocyte mediated immunityGO:0002708620.991
Mouse
regulation of interleukin 2 productionGO:0032663280.989
Mouse
natural killer cell activationGO:0030101440.989
positive regulation of leukocyte proliferationGO:0070665730.987
Mouse
immune response activating signal transductionGO:00027571160.986
Mouse
leukocyte proliferationGO:00706611720.985
Mouse
lymphocyte differentiationGO:00300982420.985
Mouse
interleukin 2 productionGO:0032623330.980
Mouse
regulation of lymphocyte activationGO:00512492400.979
Mouse
positive regulation of cytokine productionGO:00018191740.979
Mouse
t cell activationGO:00421102890.979
Mouse
regulation of t cell activationGO:00508631700.979
Mouse
regulation of cytokine biosynthetic processGO:0042035590.978
Mouse
lymphocyte mediated immunityGO:00024491390.977
Mouse
adaptive immune responseGO:00022501550.977
Mouse
t cell differentiationGO:00302171740.976
Mouse
immune response regulating cell surface receptor signaling pathwayGO:0002768800.974
Mouse
regulation of cell activationGO:00508652890.972
Mouse
stimulatory c type lectin receptor signaling pathwayGO:000222320.972
positive regulation of immune effector processGO:00026991070.959
Mouse
t cell costimulationGO:0031295140.959
Mouse
immune response regulating signaling pathwayGO:00027641250.958
Mouse
regulation of cytokine productionGO:00018172660.955
Mouse
positive regulation of innate immune responseGO:0045089800.955
cytokine productionGO:00018163190.954
Mouse
activation of immune responseGO:00022531380.949
Mouse
regulation of adaptive immune responseGO:0002819900.943
Mouse
antigen receptor mediated signaling pathwayGO:0050851640.942
Mouse
positive regulation of cytokine biosynthetic processGO:0042108400.931
Mouse
regulation of adaptive immune response based on somatic recombination of immune receptors built from immunoglobulin superfamily domainsGO:0002822870.927
Mouse
positive regulation of inflammatory response to antigenic stimulusGO:0002863110.927
Mouse
leukocyte differentiationGO:00025213420.926
Mouse
defense response to other organismGO:00985421970.925
regulation of leukocyte proliferationGO:00706631210.921
Mouse
regulation of inflammatory response to antigenic stimulusGO:0002861210.921
Mouse
regulation of leukocyte mediated immunityGO:00027031040.921
Mouse
regulation of innate immune responseGO:0045088910.918
b cell activationGO:00421131610.912
Mouse
positive regulation of interleukin 2 biosynthetic processGO:004508680.906
Mouse
positive regulation of lymphocyte proliferationGO:0050671700.896
Mouse
regulation of dendritic cell chemotaxisGO:200050810.893
cellular response to cytokine stimulusGO:00713451890.892
positive regulation of leukocyte mediated immunityGO:0002705700.891
Mouse
apoptotic signaling pathwayGO:00971903060.888
Mouse
regulation of interleukin 4 biosynthetic processGO:004540230.875
positive regulation of interleukin 2 productionGO:0032743190.875
Mouse
regulation of lymphocyte mediated immunityGO:0002706840.870
Mouse
alpha beta t cell proliferationGO:0046633210.855
Mouse
regulation of antigen receptor mediated signaling pathwayGO:0050854290.851
positive regulation of cellular amine metabolic processGO:003324050.845
t cell proliferationGO:00420981200.839
Mouse
innate immune responseGO:00450871570.839
positive regulation of inflammatory responseGO:0050729470.839
Mouse
somatic diversification of immune receptors via germline recombination within a single locusGO:0002562510.836
Mouse
humoral immune responseGO:0006959570.833
regulation of t cell differentiationGO:0045580830.832
t helper 2 cell cytokine productionGO:003574540.820
interferon gamma productionGO:0032609670.813
regulation of defense responseGO:00313472330.811
Mouse
positive regulation of cell activationGO:00508671580.809
Mouse
positive regulation of cd8 positive alpha beta t cell extravasationGO:200045120.798
regulation of b cell proliferationGO:0030888390.797
regulation of t cell proliferationGO:0042129920.794
Mouse
positive regulation of t cell proliferationGO:0042102520.792
Mouse
t cell receptor signaling pathwayGO:0050852460.778
Mouse
positive regulation of interferon gamma productionGO:0032729390.776
positive regulation of lymphocyte activationGO:00512511400.770
Mouse
b cell receptor signaling pathwayGO:0050853200.767
regulation of alpha beta t cell proliferationGO:0046640180.759
Mouse
extrinsic apoptotic signaling pathwayGO:00971911260.757
regulation of interferon gamma productionGO:0032649570.729
regulation of alpha beta t cell activationGO:0046634530.728
Mouse
regulation of inflammatory responseGO:00507271470.724
Mouse
interleukin 10 secretionGO:007260840.713
lymphocyte costimulationGO:0031294150.712
Mouse
negative regulation of protein metabolic processGO:00512482820.700
adaptive immune response based on somatic recombination of immune receptors built from immunoglobulin superfamily domainsGO:00024601450.699
Mouse
positive regulation of t cell costimulationGO:200052520.697
cell killingGO:0001906670.697
positive regulation of natural killer cell mediated cytotoxicityGO:0045954160.696
innate immune response activating signal transductionGO:0002758500.695
inflammatory response to antigenic stimulusGO:0002437300.691
Mouse
negative regulation of immune system processGO:00026832090.689
cd4 positive alpha beta t cell cytokine productionGO:003574340.681
alpha beta t cell activationGO:0046631910.658
Mouse
negative regulation of cellular amine metabolic processGO:003323910.649
regulation of lymphocyte proliferationGO:00506701170.618
Mouse
regulation of natural killer cell activationGO:0032814220.617
i kappab kinase nf kappab signalingGO:0007249850.613
cytokine mediated signaling pathwayGO:00192211150.610
regulation of response to woundingGO:19030341890.598
Mouse
positive regulation of alpha beta t cell activationGO:0046635390.596
Mouse
regulation of cellular ketone metabolic processGO:0010565660.593
cytokine metabolic processGO:0042107710.588
Mouse
negative thymic t cell selectionGO:0045060120.587
Mouse
positive regulation of leukocyte mediated cytotoxicityGO:0001912310.560
regulation of cellular amine metabolic processGO:0033238200.560
negative regulation of t cell activationGO:0050868650.550
regulation of cellular amino acid metabolic processGO:000652150.545
regulation of regulatory t cell differentiationGO:004558970.539
regulation of cytokine secretionGO:0050707610.526
b cell proliferationGO:0042100530.524
cellular amino acid metabolic processGO:00065201030.522
positive regulation of hematopoietic stem cell migrationGO:200047310.521
peptidyl tyrosine modificationGO:00182121450.512
cd4 positive alpha beta t cell differentiationGO:0043367410.506
cellular ketone metabolic processGO:0042180840.498
negative regulation of regulatory t cell differentiationGO:004559020.488
membrane fusionGO:0061025380.486
regulation of establishment of protein localizationGO:00702011810.483
negative regulation of innate immune responseGO:0045824170.483
negative regulation of leukocyte mediated immunityGO:0002704290.476
positive regulation of lymphocyte anergyGO:000291340.468
negative regulation of cellular amino acid metabolic processGO:004576300.467
positive regulation of adaptive immune responseGO:0002821610.465
Mouse
cytokine secretionGO:0050663720.461
amine metabolic processGO:0009308450.442
negative regulation of cytokine productionGO:0001818840.439
lymphocyte proliferationGO:00466511640.435
Mouse
hematopoietic stem cell migrationGO:003570110.431
positive regulation of cellular amino acid metabolic processGO:004576430.426
cell chemotaxisGO:0060326810.418
negative regulation of phosphorus metabolic processGO:00105631840.417
myeloid leukocyte activationGO:0002274830.416
negative regulation of immune effector processGO:0002698550.414
somatic diversification of immunoglobulins involved in immune responseGO:0002208360.409
Mouse
regulation of b cell mediated immunityGO:0002712370.400
Mouse
b cell mediated immunityGO:0019724710.389
Mouse
regulation of eosinophil degranulationGO:004330910.389
cell activation involved in immune responseGO:00022631260.387
Mouse
regulation of leukocyte differentiationGO:19021051590.386
response to lipopolysaccharideGO:00324961280.386
peptidyl tyrosine phosphorylationGO:00181081430.384
t cell selectionGO:0045058340.380
Mouse
negative t cell selectionGO:0043383130.377
Mouse
helper t cell chemotaxisGO:003570410.376
positive regulation of acute inflammatory responseGO:0002675160.366
t helper 17 cell chemotaxisGO:003570510.364
positive regulation of b cell mediated immunityGO:0002714260.363
Mouse
positive regulation of immunoglobulin mediated immune responseGO:0002891260.363
Mouse
vesicle fusionGO:0006906160.353
negative regulation of phosphate metabolic processGO:00459361840.350
regulation of vesicle fusionGO:003133860.344
regulation of natural killer cell mediated immunityGO:0002715190.339
leukocyte activation involved in immune responseGO:00023661260.338
Mouse
regulation of type iia hypersensitivityGO:000179640.338
positive regulation of response to woundingGO:1903036660.336
Mouse
inflammatory responseGO:00069542440.334
Mouse
activation of innate immune responseGO:0002218560.334
negative regulation of interferon gamma productionGO:0032689180.328
cell surface pattern recognition receptor signaling pathwayGO:000275220.327
natural killer cell mediated cytotoxicityGO:0042267290.325
pattern recognition receptor signaling pathwayGO:0002221470.323
tumor necrosis factor biosynthetic processGO:0042533100.323
regulation of protein transportGO:00512231630.322
regulation of peptidyl tyrosine phosphorylationGO:0050730930.320
positive regulation of cell killingGO:0031343330.318
alpha beta t cell differentiationGO:0046632690.317
protein kinase b signalingGO:0043491740.316
Mouse
immune response inhibiting cell surface receptor signaling pathwayGO:000276730.312
interleukin 12 secretionGO:007261030.311
regulation of leukocyte mediated cytotoxicityGO:0001910380.308
regulation of regulated secretory pathwayGO:1903305200.306
positive regulation of peptidyl tyrosine phosphorylationGO:0050731610.298
stress activated protein kinase signaling cascadeGO:0031098810.297
t helper cell differentiationGO:0042093280.296
defense response to gram positive bacteriumGO:0050830500.295
mapk cascadeGO:00001652810.294
regulation of monocyte extravasationGO:200043720.293
cellular amine metabolic processGO:0044106440.292
positive regulation of t cell receptor signaling pathwayGO:005086240.289
immune response inhibiting signal transductionGO:000276540.285
regulation of cell killingGO:0031341400.280
metal ion homeostasisGO:00550651890.279
regulation of secretion by cellGO:19035302490.277
defense response to bacteriumGO:00427421190.276
t cell differentiation involved in immune responseGO:0002292300.275
mature dendritic cell differentiationGO:009702930.274
regulation of t cell costimulationGO:200052320.272
divalent inorganic cation homeostasisGO:00725071380.272
regulation of vesicle mediated transportGO:00606271390.271
lymph node developmentGO:0048535180.270
negative regulation of phosphorylationGO:00423261660.262
positive regulation of adaptive immune response based on somatic recombination of immune receptors built from immunoglobulin superfamily domainsGO:0002824610.261
Mouse
alpha beta t cell activation involved in immune responseGO:0002287310.260
eosinophil activationGO:004330710.258
regulation of monocyte chemotaxisGO:009002530.253
innate immune response activating cell surface receptor signaling pathwayGO:000222040.253
production of molecular mediator of immune responseGO:00024401030.251
Mouse
immune complex clearanceGO:000243420.250
positive regulation of b cell activationGO:0050871490.246
Mouse
reactive oxygen species metabolic processGO:0072593840.245
regulation of lymphocyte differentiationGO:00456191070.244
negative regulation of eosinophil degranulationGO:004331010.243
positive regulation of protein kinase b signalingGO:0051897320.240
Mouse
negative regulation of leukocyte differentiationGO:1902106510.239
granulocyte chemotaxisGO:0071621390.239
defense response to virusGO:0051607680.235
regulation of ion transportGO:00432692150.230
regulation of t cell extravasationGO:200040730.230
positive regulation of alpha beta t cell proliferationGO:0046641120.229
Mouse
regulation of corticotropin releasing hormone secretionGO:004339720.226
regulation of kinase activityGO:00435492490.225
b cell activation involved in immune responseGO:0002312500.221
Mouse
positive regulation of monocyte extravasationGO:200043910.218
positive regulation of cell deathGO:00109422240.216
eosinophil activation involved in immune responseGO:000227810.216
dna recombinationGO:0006310920.214
Mouse
toll like receptor signaling pathwayGO:0002224380.214
regulation of organelle organizationGO:00330432890.212
lymphocyte apoptotic processGO:0070227540.210
positive regulation of protein phosphorylationGO:00019342420.210
positive regulation of dendritic cell chemotaxisGO:200051010.209
negative regulation of defense responseGO:0031348770.209
inositol lipid mediated signalingGO:0048017410.208
Mouse
endocytosisGO:00068971680.206
regulation of protein kinase activityGO:00458592320.199
negative regulation of protein phosphorylationGO:00019331260.198
cell cell adhesion via plasma membrane adhesion moleculesGO:0098742400.197
t cell mediated immunityGO:0002456500.196
cellular response to molecule of fungal originGO:007122620.195
positive regulation of isotype switching to igg isotypesGO:004830470.195
Mouse
natural killer cell mediated immunityGO:0002228290.195
regulation of interleukin 1 beta secretionGO:0050706150.194
cd4 positive alpha beta t cell differentiation involved in immune responseGO:0002294280.194
regulation of protein secretionGO:0050708820.190
immunoglobulin mediated immune responseGO:0016064690.190
Mouse
regulation of immunological synapse formationGO:200052020.190
cytokine biosynthetic processGO:0042089680.187
Mouse
myeloid cell differentiationGO:00300992330.187
regulation of t helper 2 cell cytokine productionGO:200055130.186
t cell activation involved in immune responseGO:0002286430.185
protein secretionGO:00093061110.185
cellular response to molecule of bacterial originGO:0071219830.184
glycoprotein biosynthetic processGO:0009101890.183
positive regulation of leukocyte differentiationGO:1902107860.183
regulatory t cell differentiationGO:0045066100.180
regulation of mapk cascadeGO:00434082480.180
microglial cell activation involved in immune responseGO:000228210.179
g protein coupled receptor signaling pathwayGO:00071862430.178
regulation of cd8 positive alpha beta t cell extravasationGO:200044930.178
regulation of acute inflammatory responseGO:0002673270.177
regulation of b cell activationGO:0050864810.174
Mouse
t cell extravasationGO:007268340.172
interleukin 12 productionGO:0032615320.172
somatic cell dna recombinationGO:0016444510.168
Mouse
positive regulation of intracellular transportGO:0032388700.166
negative regulation of protein modification processGO:00314001630.165
regulation of extrinsic apoptotic signaling pathwayGO:2001236770.161
negative regulation of growthGO:0045926990.161
regulation of cd4 positive alpha beta t cell activationGO:2000514240.159
cellular response to lipidGO:00713961450.159
regulation of apoptotic signaling pathwayGO:20012331970.154
peptidyl amino acid modificationGO:00181933360.154
regulation of peptidase activityGO:0052547960.153
interleukin 4 productionGO:0032633240.153
glycoprotein metabolic processGO:00091001160.151
positive regulation of monocyte chemotaxisGO:009002620.149
t helper 2 cell differentiationGO:0045064120.149
regulation of interleukin 10 secretionGO:200117940.145
negative regulation of cell activationGO:00508661110.145
regulation of protein localizationGO:00328802310.143
release of sequestered calcium ion into cytosolGO:0051209420.142
negative regulation of intracellular signal transductionGO:19025321670.141
dendritic cell differentiationGO:0097028260.140
regulation of immune complex clearance by monocytes and macrophagesGO:009026420.139
lipopolysaccharide mediated signaling pathwayGO:0031663250.139
negative regulation of multi organism processGO:0043901680.138
cdc42 protein signal transductionGO:003248800.138
positive regulation of protein secretionGO:0050714520.136
eosinophil mediated immunityGO:000244710.135
sequestering of calcium ionGO:0051208180.135
interleukin 2 biosynthetic processGO:0042094150.133
Mouse
positive regulation of cell developmentGO:00107202370.133
positive regulation of homeostatic processGO:0032846640.133
membrane organizationGO:00610242450.133
positive regulation of cytokine secretionGO:0050715410.132
negative regulation of cellular protein metabolic processGO:00322692470.132
regulation of immunoglobulin mediated immune responseGO:0002889370.130
Mouse
gliogenesisGO:00420631410.129
myeloid leukocyte mediated immunityGO:0002444420.128
regulation of map kinase activityGO:00434051200.128
ensheathment of neuronsGO:0007272760.128
sequestering of metal ionGO:0051238190.127
regulation of interleukin 4 productionGO:0032673180.126
regulation of calcium ion transport into cytosolGO:0010522310.125
positive regulation of hydrolase activityGO:00513451480.125
positive regulation of tumor necrosis factor superfamily cytokine productionGO:1903557310.123
lymphocyte migrationGO:0072676260.123
response to molecule of bacterial originGO:00022371430.121
regulation of lipid transportGO:0032368360.120
positive regulation of interleukin 13 productionGO:003273640.120
positive regulation of lymphocyte differentiationGO:0045621610.120
tumor necrosis factor mediated signaling pathwayGO:0033209130.117
neuronal action potentialGO:0019228540.116
regulation of toll like receptor 2 signaling pathwayGO:003413530.116
negative regulation of b cell activationGO:0050869270.116
granzyme mediated apoptotic signaling pathwayGO:000862610.115
monocyte extravasationGO:003569620.115
humoral immune response mediated by circulating immunoglobulinGO:0002455140.115
positive regulation of natural killer cell mediated immunityGO:0002717160.114
cation transportGO:00068123990.114
positive regulation of secretion by cellGO:19035321140.114
myeloid cell activation involved in immune responseGO:0002275340.114
ribonucleotide metabolic processGO:00092592910.113
regulation of interleukin 1 beta productionGO:0032651250.112
necrotic cell deathGO:0070265300.110
vesicle organizationGO:0016050600.110
positive regulation of t cell migrationGO:2000406100.109
regulation of type 2 immune responseGO:0002828180.108
leukocyte mediated cytotoxicityGO:0001909620.107
positive regulation of lymphocyte migrationGO:2000403110.107
transmission of nerve impulseGO:0019226760.107
antigen processing and presentationGO:0019882470.107
regulation of stress activated mapk cascadeGO:0032872690.106
positive regulation of chronic inflammatory response to antigenic stimulusGO:000287620.106
modulation of growth of symbiont involved in interaction with hostGO:0044144190.105
phosphatidylinositol mediated signalingGO:0048015410.104
Mouse
positive regulation of mapk cascadeGO:00434101700.104
negative regulation of cell proliferationGO:00082852960.104
organonitrogen compound catabolic processGO:19015652640.104
rho protein signal transductionGO:0007266320.103
positive regulation of t cell extravasationGO:200040920.103
somatic diversification of immunoglobulinsGO:0016445430.102
Mouse
nucleoside phosphate metabolic processGO:00067533380.101
regulation of cysteine type endopeptidase activityGO:2000116650.101
mast cell activationGO:0045576270.101
cellular response to lipopolysaccharideGO:0071222770.100
response to organic cyclic compoundGO:00140701980.099
negative regulation of natural killer cell mediated immunityGO:000271650.099
regulation of lymphocyte apoptotic processGO:0070228410.098
cellular calcium ion homeostasisGO:00068741190.098
myeloid leukocyte differentiationGO:00025731190.098
response to drugGO:0042493750.097
activation of jun kinase activityGO:0007257150.097
positive regulation of chemotaxisGO:0050921380.097
positive regulation of acute inflammatory response to antigenic stimulusGO:000286670.096
positive regulation of alpha beta t cell differentiationGO:0046638280.094
nucleobase containing small molecule metabolic processGO:00550863520.093
second messenger mediated signalingGO:0019932730.093
positive regulation of immunological synapse formationGO:200052210.092
somatic recombination of immunoglobulin gene segmentsGO:0016447420.092
Mouse
t helper 17 cell lineage commitmentGO:007254040.092
t cell differentiation in thymusGO:0033077770.091
Mouse
regulation of intracellular transportGO:00323861590.091
positive regulation of t helper 2 cell cytokine productionGO:200055330.091
regulation of myeloid cell differentiationGO:0045637960.091
cytosolic calcium ion transportGO:0060401480.090
dendritic cell chemotaxisGO:000240770.090
positive regulation of translational initiation by ironGO:004599420.090
positive regulation of oligodendrocyte differentiationGO:004871490.090
acute inflammatory response to antigenic stimulusGO:0002438120.089
positive regulation of phospholipase c activityGO:001086320.089
protein maturationGO:00516041760.089
jnk cascadeGO:0007254720.088
regulation of protein targetingGO:1903533610.088
cellular homeostasisGO:00197252400.088
negative regulation of secretionGO:0051048610.088
carbohydrate derivative biosynthetic processGO:19011371830.088
positive regulation of reactive oxygen species biosynthetic processGO:190342820.087
regulation of secretionGO:00510462740.087
symbiosis encompassing mutualism through parasitismGO:0044403830.087
nitrogen compound transportGO:00717052710.086
multicellular organismal signalingGO:0035637910.086
cytokine production involved in immune responseGO:0002367340.086
methylationGO:00322591340.085
type 2 immune responseGO:0042092230.085
phagocytosisGO:0006909660.084
negative regulation of interleukin 2 biosynthetic processGO:004508530.084
cellular response to biotic stimulusGO:0071216920.084
regulation of t cell receptor signaling pathwayGO:0050856210.084
positive regulation of secretionGO:00510471300.084
regulation of tumor necrosis factor biosynthetic processGO:0042534100.084
leukocyte degranulationGO:0043299270.084
negative regulation of leukocyte proliferationGO:0070664460.084
interleukin 13 secretionGO:007261120.084
interleukin 2 mediated signaling pathwayGO:003811020.084
isotype switchingGO:0045190360.084
Mouse
positive regulation of endocytosisGO:0045807420.083
macrophage activationGO:0042116270.083
dna metabolic processGO:00062593030.082
Mouse
granulocyte activationGO:0036230100.082
positive regulation of interferon alpha productionGO:003272740.081
positive regulation of t cell anergyGO:000266940.081
cd8 positive alpha beta t cell extravasationGO:003569730.081
regulation of myeloid leukocyte mediated immunityGO:0002886250.081
negative regulation of t cell proliferationGO:0042130380.081
glucose metabolic processGO:0006006920.080
purine containing compound metabolic processGO:00725213110.080
regulation of reactive oxygen species metabolic processGO:2000377400.079
immunoglobulin secretionGO:0048305170.079
regulation of interleukin 13 secretionGO:200066520.079
corticotropin releasing hormone secretionGO:004339620.079
regulation of hydrolase activityGO:00513362460.078
t cell chemotaxisGO:001081860.078
protein localization to organelleGO:00333651850.078
positive regulation of lipid transportGO:0032370220.077
growth of symbiont in hostGO:0044117230.077
negative regulation of b cell proliferationGO:0030889130.077
fever generationGO:000166070.077
interleukin 5 secretionGO:007260320.077
regulation of chemokine productionGO:0032642300.076
regulation of lymphocyte anergyGO:000291140.076
regulation of tumor necrosis factor productionGO:0032680490.075
cellular metal ion homeostasisGO:00068751510.075
positive regulation of t cell differentiationGO:0045582520.074
osteoclast differentiationGO:0030316620.074
cellular response to interleukin 15GO:007135020.074
action potentialGO:0001508780.074
cellular ion homeostasisGO:00068731650.074
negative regulation of lymphocyte activationGO:0051250910.073
growth involved in symbiotic interactionGO:0044110230.073
divalent metal ion transportGO:00708381720.073
b cell differentiationGO:0030183780.072
regulation of endopeptidase activityGO:0052548890.072
positive regulation of protein modification processGO:00314012990.070
positive regulation of immunoglobulin production in mucosal tissueGO:200055810.070
negative regulation of lymphocyte proliferationGO:0050672450.070
regulation of growth of symbiont in hostGO:0044126190.069
thymic t cell selectionGO:0045061220.069
Mouse
positive regulation of interferon gamma biosynthetic processGO:004507840.069
lymphocyte activation involved in immune responseGO:0002285930.069
Mouse
positive regulation of immunoglobulin productionGO:0002639280.069
Mouse
regulation of hormone levelsGO:00108172110.068
activation of mapk activityGO:0000187590.068
regulation of toll like receptor 4 signaling pathwayGO:003414340.068
nucleotide metabolic processGO:00091173320.067
inflammatory cell apoptotic processGO:0006925110.066
cytoplasmic transportGO:00164822340.066
transmembrane receptor protein tyrosine kinase signaling pathwayGO:00071692470.066
detection of yeastGO:000187920.066
cell type specific apoptotic processGO:00972852680.066
tumor necrosis factor superfamily cytokine productionGO:0071706510.066
positive regulation of interleukin 12 productionGO:0032735210.066
t cell migrationGO:0072678190.066
regulation of protein maturationGO:1903317960.065
regulation of synaptic growth at neuromuscular junctionGO:000858240.064
positive regulation of immune complex clearance by monocytes and macrophagesGO:009026520.064
negative regulation of toll like receptor 2 signaling pathwayGO:003413630.064
regulation of epidermal growth factor receptor signaling pathwayGO:0042058130.064
establishment of protein localization to organelleGO:00725941180.064
alpha beta t cell differentiation involved in immune responseGO:0002293300.063
regulation of transferase activityGO:00513382630.063
positive regulation of stress activated mapk cascadeGO:0032874480.063
maintenance of locationGO:0051235890.062
t cell lineage commitmentGO:0002360130.062
protein homotrimerizationGO:007020740.062
negative regulation of interleukin 10 secretionGO:200118020.062
programmed necrotic cell deathGO:0097300280.061
anatomical structure homeostasisGO:00602491450.060
regulation of protein serine threonine kinase activityGO:00719001570.060
positive t cell selectionGO:0043368230.060
regulation of phagocytosisGO:0050764330.060
positive regulation of organelle organizationGO:00106381280.060
positive regulation of type ii hypersensitivityGO:000289440.060
negative regulation of secretion by cellGO:1903531540.059
response to peptideGO:19016521360.059
detection of mechanical stimulus involved in sensory perception of painGO:005096640.059
phosphatidylinositol 3 kinase signalingGO:0014065360.059
Mouse
positive regulation of jnk cascadeGO:0046330460.058
positive regulation of cd4 positive alpha beta t cell proliferationGO:200056310.058
negative regulation of macrophage apoptotic processGO:200011030.058
t cell apoptotic processGO:0070231390.058
negative regulation of growth of symbiont in hostGO:0044130190.058
tissue remodelingGO:00487711020.058
glial cell apoptotic processGO:003434930.056
positive regulation of intracellular protein transportGO:0090316420.056
response to molecule of fungal originGO:000223840.056
axon ensheathmentGO:0008366760.056
aromatic compound catabolic processGO:00194392860.056
extrinsic apoptotic signaling pathway in absence of ligandGO:0097192550.056
positive regulation of reactive oxygen species metabolic processGO:2000379110.056
lymphocyte anergyGO:000224940.056
positive regulation of myoblast differentiationGO:004566380.056
signal transduction in absence of ligandGO:0038034550.056
positive regulation of phagocytosisGO:0050766260.055
anion transportGO:00068201770.055
bone resorptionGO:0045453380.055
regulation of alpha beta t cell differentiationGO:0046637350.054
sensitizationGO:004696020.054
regulation of peptide transportGO:0090087910.054
regulation of syncytium formation by plasma membrane fusionGO:0060142230.054
single organism cell adhesionGO:00986021560.054
homeostasis of number of cellsGO:00488722100.054
purine ribonucleoside metabolic processGO:00461282410.053
dephosphorylationGO:00163111290.053
positive regulation of epithelial cell proliferationGO:0050679680.053

Icos disease predictions

Disease predictions are made from cross-annotation of human disease genes to the identified functional analogs in mouse and predicted with the mouse functional network.

DiseaseDO term IDSizeProbabilityFunc Analog Org
immune system diseaseDOID:291400.116
hypersensitivity reaction diseaseDOID:006005600.116
disease of anatomical entityDOID:700.116
primary immunodeficiency diseaseDOID:61200.074
b cell deficiencyDOID:211500.074