Mus musculus

51 known processes

Akr1a4

aldo-keto reductase family 1, member A4 (aldehyde reductase)

(Aliases: Akr1a1,2610201A18Rik)

Akr1a4 biological process predictions


Filter by process size:
Biological processGO term IDProcess sizeProbabilityFunc Analog Org
cellular amino acid metabolic processGO:00065201030.270
cytoplasmic transportGO:00164822340.263
apoptotic signaling pathwayGO:00971903060.194
cellular divalent inorganic cation homeostasisGO:00725031270.188
extrinsic apoptotic signaling pathwayGO:00971911260.139
positive regulation of cellular amino acid metabolic processGO:004576430.119
regulation of apoptotic signaling pathwayGO:20012331970.116
cation transportGO:00068123990.112
ion transmembrane transportGO:00342203610.110
cation homeostasisGO:00550802120.107
male gamete generationGO:00482322850.106
regulation of cellular amino acid metabolic processGO:000652150.091
cellular metal ion homeostasisGO:00068751510.084
positive regulation of programmed cell deathGO:00430682180.080
macromolecule catabolic processGO:00090572810.078
cellular homeostasisGO:00197252400.076
sulfur compound metabolic processGO:00067901000.076
regulation of bindingGO:00510981110.075
cellular ketone metabolic processGO:0042180840.072
Mouse
cellular ion homeostasisGO:00068731650.071
regulation of cellular ketone metabolic processGO:0010565660.068
regulation of intracellular transportGO:00323861590.068
positive regulation of cell deathGO:00109422240.068
regulation of ion transportGO:00432692150.068
cellular modified amino acid metabolic processGO:0006575630.068
positive regulation of secretionGO:00510471300.065
regulation of cell activationGO:00508652890.065
proteolysis involved in cellular protein catabolic processGO:00516031470.064
metal ion homeostasisGO:00550651890.063
membrane organizationGO:00610242450.062
regulation of extrinsic apoptotic signaling pathwayGO:2001236770.061
meiotic nuclear divisionGO:00071261150.060
negative regulation of protein metabolic processGO:00512482820.059
gonad developmentGO:00084061410.058
carbohydrate derivative catabolic processGO:19011362310.058
vesicle organizationGO:0016050600.057
oxidation reduction processGO:00551143420.057
maintenance of locationGO:0051235890.056
regulation of synaptic growth at neuromuscular junctionGO:000858240.056
positive regulation of necrotic cell deathGO:001094010.056
regulation of leukocyte differentiationGO:19021051590.054
protein localization to nucleusGO:00345041210.053
protein maturationGO:00516041760.052
endocytosisGO:00068971680.051
response to amino acidGO:0043200370.050
regulation of lymphocyte activationGO:00512492400.050
negative regulation of cellular protein metabolic processGO:00322692470.050
homeostasis of number of cellsGO:00488722100.050
positive regulation of apoptotic processGO:00430652170.050
amine metabolic processGO:0009308450.049
calcium ion homeostasisGO:00550741270.048
development of primary sexual characteristicsGO:00451371430.048
protein import into nucleusGO:0006606950.048
cellular amine metabolic processGO:0044106440.048
regulation of establishment of protein localizationGO:00702011810.046
response to inorganic substanceGO:0010035960.046
protein catabolic processGO:00301632210.046
lymphocyte differentiationGO:00300982420.046
spermatogenesisGO:00072832840.046
positive regulation of secretion by cellGO:19035321140.045
calcium ion transportGO:00068161590.044
positive regulation of exocytosisGO:0045921200.044
signal transduction in absence of ligandGO:0038034550.044
positive regulation of mapk cascadeGO:00434101700.044
establishment of protein localization to organelleGO:00725941180.043
regulation of secretion by cellGO:19035302490.043
intracellular protein transportGO:00068862040.043
regulation of hydrolase activityGO:00513362460.043
regulation of secretionGO:00510462740.042
ubiquitin dependent protein catabolic process via the multivesicular body sorting pathwayGO:004316230.041
ameboidal type cell migrationGO:00016671280.040
negative regulation of cell proliferationGO:00082852960.040
leukocyte mediated cytotoxicityGO:0001909620.040
golgi vesicle transportGO:0048193300.040
engulfment of apoptotic cellGO:004365230.039
positive regulation of cellular amine metabolic processGO:003324050.038
regulation of protein localizationGO:00328802310.038
myeloid cell differentiationGO:00300992330.038
regulation of t cell activationGO:00508631700.038
wound healingGO:00420601570.038
dna metabolic processGO:00062593030.038
granzyme mediated apoptotic signaling pathwayGO:000862610.037
tissue homeostasisGO:00018941150.037
nucleobase containing small molecule metabolic processGO:00550863520.037
lymphocyte proliferationGO:00466511640.037
regulation of protein kinase activityGO:00458592320.037
t cell activationGO:00421102890.036
protein localization to organelleGO:00333651850.036
regulation of protein stabilityGO:0031647520.036
extrinsic apoptotic signaling pathway in absence of ligandGO:0097192550.035
regulation of cellular amine metabolic processGO:0033238200.034
sequestering of metal ionGO:0051238190.033
innate immune responseGO:00450871570.033
regulation of cellular response to stressGO:00801351590.033
negative regulation of molecular functionGO:00440922580.033
regulation of cytoplasmic transportGO:19036491120.033
actin cytoskeleton organizationGO:00300362200.033
regulation of intracellular protein transportGO:0033157820.032
cellular chemical homeostasisGO:00550822150.032
peptidyl amino acid modificationGO:00181933360.032
cation transmembrane transportGO:00986552660.032
organonitrogen compound catabolic processGO:19015652640.032
maternal placenta developmentGO:0001893200.031
regulation of response to woundingGO:19030341890.031
arp2 3 complex mediated actin nucleationGO:003431430.031
cellular protein catabolic processGO:00442571550.031
regulation of intrinsic apoptotic signaling pathwayGO:2001242610.031
response to oxidative stressGO:00069791230.031
Yeast
multicellular organismal homeostasisGO:00488711640.030
modification dependent macromolecule catabolic processGO:00436321330.030
positive regulation of cytosolic calcium ion concentrationGO:0007204650.030
extracellular structure organizationGO:00430621480.030
regulation of membrane potentialGO:00423911920.030
necrotic cell deathGO:0070265300.030
positive regulation of peptidase activityGO:0010952490.030
regulation of mapk cascadeGO:00434082480.030
response to organonitrogen compoundGO:00102432460.029
posttranscriptional regulation of gene expressionGO:00106081550.029
cellular macromolecule catabolic processGO:00442652060.029
cell killingGO:0001906670.029
nuclear divisionGO:00002801580.028
immune effector processGO:00022523210.028
purine ribonucleotide metabolic processGO:00091502900.028
leukocyte mediated immunityGO:00024431740.028
regulation of map kinase activityGO:00434051200.028
positive regulation of cell activationGO:00508671580.028
transmembrane transportGO:00550854120.028
epidermis developmentGO:00085441870.027
nuclear importGO:0051170950.027
cellular calcium ion homeostasisGO:00068741190.027
cytosolic calcium ion homeostasisGO:0051480700.027
renal system developmentGO:00720012250.027
nucleotide metabolic processGO:00091173320.027
reactive oxygen species metabolic processGO:0072593840.026
regulation of defense responseGO:00313472330.026
skin developmentGO:00435882200.026
inorganic ion transmembrane transportGO:00986602340.026
cell type specific apoptotic processGO:00972852680.026
purine ribonucleotide catabolic processGO:00091542080.026
t cell differentiationGO:00302171740.025
cellular response to dna damage stimulusGO:00069742070.025
mapk cascadeGO:00001652810.025
regulation of peptidase activityGO:0052547960.025
divalent inorganic cation homeostasisGO:00725071380.025
regulation of protein transportGO:00512231630.025
heterocycle catabolic processGO:00467002800.025
mesonephros developmentGO:0001823970.025
purine nucleotide catabolic processGO:00061952110.025
regulation of nucleocytoplasmic transportGO:0046822730.025
epithelial tube morphogenesisGO:00605623030.025
regulation of proteolysisGO:00301621640.025
nucleocytoplasmic transportGO:00069131390.025
modification dependent protein catabolic processGO:00199411330.025
nuclear transportGO:00511691390.025
purine containing compound metabolic processGO:00725213110.025
divalent metal ion transportGO:00708381720.024
kidney developmentGO:00018222130.024
anatomical structure homeostasisGO:00602491450.024
positive regulation of protein modification processGO:00314012990.024
regulation of vesicle mediated transportGO:00606271390.024
ribonucleoside metabolic processGO:00091192450.024
hydrogen ion transmembrane transportGO:1902600250.024
actin polymerization or depolymerizationGO:0008154540.023
regulation of arp2 3 complex mediated actin nucleationGO:003431510.023
endomembrane system organizationGO:00102561470.023
ribose phosphate metabolic processGO:00196932910.023
cell fate commitmentGO:00451652100.023
monosaccharide metabolic processGO:00059961060.023
meiotic cell cycleGO:00513211220.023
ketone catabolic processGO:004218230.022
Mouse
central nervous system morphogenesisGO:002155120.022
regulation of protein localization to nucleusGO:1900180600.022
cellular response to oxidative stressGO:0034599760.022
Yeast
hemostasisGO:0007599780.022
organophosphate catabolic processGO:00464342320.022
nucleoside catabolic processGO:00091642060.022
sequestering of calcium ionGO:0051208180.022
leukocyte differentiationGO:00025213420.022
embryonic organ morphogenesisGO:00485622760.022
lymphocyte activation involved in immune responseGO:0002285930.021
nucleotide catabolic processGO:00091662170.021
actin filament branchingGO:009013510.021
positive regulation of apoptotic signaling pathwayGO:2001235950.021
inter male aggressive behaviorGO:000212130.021
proteasomal protein catabolic processGO:0010498980.020
meiotic cell cycle processGO:1903046770.020
gland developmentGO:00487323300.020
multi multicellular organism processGO:00447061090.020
Mouse
response to organic cyclic compoundGO:00140701980.020
asymmetric stem cell divisionGO:009872230.020
inorganic cation transmembrane transportGO:00986622070.020
calcium ion transmembrane transportGO:0070588850.020
purine containing compound catabolic processGO:00725232130.020
nitrogen compound transportGO:00717052710.020
positive regulation of wnt signaling pathwayGO:0030177450.020
regulation of body fluid levelsGO:00508781620.020
blood coagulationGO:0007596760.020
negative regulation of protein modification processGO:00314001630.019
cytosolic calcium ion transportGO:0060401480.019
sensory organ morphogenesisGO:00905962420.019
positive regulation of lymphocyte activationGO:00512511400.019
regulation of protein import into nucleusGO:0042306520.019
camera type eye developmentGO:00430102660.019
heart morphogenesisGO:00030071780.019
positive regulation of actin nucleationGO:005112730.019
superoxide metabolic processGO:0006801270.019
ribonucleotide metabolic processGO:00092592910.019
regulation of anatomical structure sizeGO:00900661780.018
inflammatory responseGO:00069542440.018
divalent inorganic cation transportGO:00725111780.018
ubiquitin dependent protein catabolic processGO:00065111290.018
protein processingGO:00164851630.018
extracellular matrix organizationGO:00301981470.018
regulation of transferase activityGO:00513382630.018
regulation of protein targetingGO:1903533610.018
positive regulation of cysteine type endopeptidase activityGO:2001056390.018
nucleoside phosphate metabolic processGO:00067533380.018
aromatic compound catabolic processGO:00194392860.018
organic cyclic compound catabolic processGO:19013612950.018
Mouse
response to metal ionGO:0010038470.018
positive regulation of cellular component biogenesisGO:0044089940.018
cellular response to thyroid hormone stimulusGO:009706710.018
natural killer cell activation involved in immune responseGO:0002323100.017
regulation of transcription regulatory region dna bindingGO:200067790.017
negative regulation of lymphocyte activationGO:0051250910.017
er to golgi vesicle mediated transportGO:0006888110.017
actin filament polymerizationGO:0030041440.017
positive regulation of lamellipodium assemblyGO:001059220.017
purine ribonucleoside metabolic processGO:00461282410.017
nucleoside triphosphate metabolic processGO:00091412300.017
glycosyl compound catabolic processGO:19016582060.017
sensory perceptionGO:00076002450.017
response to reactive oxygen speciesGO:0000302560.017
regulation of protein serine threonine kinase activityGO:00719001570.017
natural killer cell degranulationGO:004332030.017
cellular response to lipidGO:00713961450.017
rho protein signal transductionGO:0007266320.017
protein importGO:00170381010.017
neuronal action potentialGO:0019228540.017
negative regulation of cell activationGO:00508661110.017
muscle cell differentiationGO:00426922610.017
negative regulation of t cell activationGO:0050868650.016
skeletal system developmentGO:00015013560.016
regulation of homeostatic processGO:00328441820.016
negative regulation of sequence specific dna binding transcription factor activityGO:0043433400.016
purine nucleoside metabolic processGO:00422782410.016
male gonad developmentGO:0008584880.016
ear morphogenesisGO:00424711180.016
positive regulation of ossificationGO:0045778470.016
positive regulation of lamellipodium organizationGO:190274530.016
positive regulation of map kinase activityGO:0043406840.016
protein targetingGO:00066051430.016
microtubule based transportGO:0010970500.016
regulation of actin nucleationGO:005112540.016
protein stabilizationGO:0050821250.015
negative regulation of extrinsic apoptotic signaling pathwayGO:2001237450.015
positive regulation of growthGO:00459271040.015
regulation of multi organism processGO:00439001110.015
regulation of cellular component biogenesisGO:00440871810.015
positive regulation of organelle organizationGO:00106381280.015
negative regulation of protein phosphorylationGO:00019331260.015
negative regulation of proteolysisGO:0045861740.015
regulation of ossificationGO:00302781120.015
peptide transportGO:00158331330.014
cellular response to molecule of bacterial originGO:0071219830.014
leukocyte proliferationGO:00706611720.014
negative regulation of vesicle fusionGO:003133910.014
morphogenesis of a branching epitheliumGO:00611381930.014
intrinsic apoptotic signaling pathwayGO:00971931320.014
cellular response to lipopolysaccharideGO:0071222770.014
regulation of kinase activityGO:00435492490.014
mitotic cell cycleGO:00002781950.014
regulation of lymphocyte differentiationGO:00456191070.014
regulation of cell motilityGO:20001452360.014
urogenital system developmentGO:00016552610.014
mitotic cytokinesisGO:000028140.014
positive regulation of mitochondrial calcium ion concentrationGO:005156130.014
sensory system developmentGO:004888030.014
regulation of leukocyte proliferationGO:00706631210.014
regulation of wnt signaling pathwayGO:00301111230.014
multicellular organismal signalingGO:0035637910.014
regulation of transmembrane transportGO:00347621280.014
cellular response to glucose stimulusGO:0071333450.014
protein ubiquitinationGO:00165671710.014
male sex differentiationGO:00466611090.013
t cell proliferationGO:00420981200.013
nucleoside phosphate catabolic processGO:19012922220.013
positive regulation of synaptic plasticityGO:003191540.013
lipid localizationGO:00108761260.013
regulation of cell shapeGO:0008360390.013
organic hydroxy compound metabolic processGO:19016152030.013
multicellular organism growthGO:00352641610.013
regulation of ion transmembrane transportGO:00347651190.013
ossificationGO:00015032160.013
proton transportGO:0015992350.013
protein modification by small protein conjugationGO:00324461870.013
regulation of metal ion transportGO:00109591060.013
negative regulation of apoptotic signaling pathwayGO:20012341040.013
regulation of lymphocyte proliferationGO:00506701170.013
removal of superoxide radicalsGO:0019430120.013
protein secretionGO:00093061110.013
negative regulation of neuron deathGO:1901215980.013
molting cycleGO:0042303900.013
second messenger mediated signalingGO:0019932730.013
mechanoreceptor differentiationGO:0042490670.013
purine ribonucleoside catabolic processGO:00461302050.013
calcium mediated signaling using intracellular calcium sourceGO:003558430.013
blood vessel morphogenesisGO:00485142850.013
regulation of ion homeostasisGO:2000021640.013
negative regulation of immune system processGO:00026832090.013
rna interferenceGO:001624620.012
adult locomotory behaviorGO:0008344910.012
response to molecule of bacterial originGO:00022371430.012
response to acid chemicalGO:00011011110.012
protein oligomerizationGO:0051259670.012
bone developmentGO:00603481200.012
receptor mediated endocytosisGO:0006898510.012
hematopoietic progenitor cell differentiationGO:00022441430.012
regulation of neuron deathGO:19012141340.012
regulation of calcium ion transport into cytosolGO:0010522310.012
ceramide biosynthetic processGO:0046513200.012
circulatory system processGO:00030131970.012
nucleoside triphosphate catabolic processGO:00091432050.012
placenta developmentGO:00018901400.012
amide transportGO:00428861380.012
regulation of neuron differentiationGO:00456642810.012
posttranscriptional gene silencing by rnaGO:0035194100.012
lateral line system developmentGO:004892510.012
purine nucleotide metabolic processGO:00061633020.012
response to lipopolysaccharideGO:00324961280.012
wnt signaling pathwayGO:00160551880.012
cellular response to oxygen radicalGO:0071450140.012
lateral inhibitionGO:004633110.012
connective tissue developmentGO:00614481790.012
negative regulation of cellular component organizationGO:00511291940.012
organophosphate biosynthetic processGO:00904071220.012
regulation of reactive oxygen species metabolic processGO:2000377400.012
positive regulation of cell developmentGO:00107202370.012
membrane fusionGO:0061025380.012
myeloid leukocyte differentiationGO:00025731190.012
fucose metabolic processGO:000600410.011
leukocyte homeostasisGO:0001776790.011
positive regulation of response to woundingGO:1903036660.011
regulation of voltage gated calcium channel activityGO:190138540.011
calcium ion transport into cytosolGO:0060402480.011
transcription factor import into nucleusGO:0042991260.011
single organism nuclear importGO:1902593950.011
diol metabolic processGO:003431150.011
tissue remodelingGO:00487711020.011
regulation of transporter activityGO:0032409570.011
transmembrane receptor protein serine threonine kinase signaling pathwayGO:00071781940.011
microtubule based processGO:00070172360.011
plasma cell differentiationGO:000231730.011
regulation of cell migrationGO:00303342190.011
axon ensheathmentGO:0008366760.011
nucleoside metabolic processGO:00091162460.011
lipid storageGO:0019915360.011
ras protein signal transductionGO:0007265770.011
regulation of actin cytoskeleton organizationGO:0032956840.011
purine nucleoside triphosphate catabolic processGO:00091462030.011
regulation of calcium ion transportGO:0051924690.011
cellular protein complex assemblyGO:00436231160.011
epithelial cell developmentGO:00020641590.011
retina development in camera type eyeGO:00600411190.011
positive regulation of cell cycle processGO:0090068610.011
development of primary male sexual characteristicsGO:0046546880.010
ribonucleotide catabolic processGO:00092612080.010
purine ribonucleoside triphosphate catabolic processGO:00092071990.010
notochord cell developmentGO:006003510.010
regulation of dna bindingGO:0051101390.010
muscle cell fate specificationGO:004269410.010
regulation of epithelial cell proliferationGO:00506781410.010
morphogenesis of embryonic epitheliumGO:00163311590.010
plasma membrane organizationGO:0007009900.010
protein polymerizationGO:0051258570.010
cellular component assembly involved in morphogenesisGO:00109271390.010
bundle of his developmentGO:000316640.010
regulation of leukocyte mediated immunityGO:00027031040.010
regulation of coagulationGO:0050818310.010
regulation of transcription factor import into nucleusGO:0042990240.010
regulation of neuron apoptotic processGO:00435231220.010
hexose metabolic processGO:0019318980.010
Yeast
maternal process involved in female pregnancyGO:0060135320.010

Akr1a4 disease predictions

Disease predictions are made from cross-annotation of human disease genes to the identified functional analogs in mouse and predicted with the mouse functional network.

DiseaseDO term IDSizeProbabilityFunc Analog Org
disease of metabolismDOID:001466700.052
central nervous system diseaseDOID:33100.037
disease of anatomical entityDOID:700.037
nervous system diseaseDOID:86300.037
musculoskeletal system diseaseDOID:1700.034
connective tissue diseaseDOID:6500.034
bone diseaseDOID:008000100.034
bone development diseaseDOID:008000600.034
immune system diseaseDOID:291400.019
osteochondrodysplasiaDOID:225600.018
inherited metabolic disorderDOID:65500.018
sensory system diseaseDOID:005015500.015
lysosomal storage diseaseDOID:321100.015
lipid storage diseaseDOID:945500.015
sphingolipidosisDOID:192700.015
neurodegenerative diseaseDOID:128900.013
brain diseaseDOID:93600.012
epilepsy syndromeDOID:182600.011
electroclinical syndromeDOID:005070100.011