IMP: Integrative Multi-species Prediction

Mus musculus

0 known processes

Ufd1l

ubiquitin fusion degradation 1 like

(Aliases: Ufd1)

Entrez: 22230
Ensembl: ENSMUSG00000005262
UniProtKB: P70362

Process Predictions
Disease Predictions

Ufd1l biological process predictions

Show only novel predictionsHighlight processes of functional analogs

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Biological process	GO term ID	Process size	Probability
inclusion body assembly	GO:0070841	3	0.582
cellular response to misfolded protein	GO:0071218	5	0.535
membrane fusion	GO:0061025	38	0.452
response to misfolded protein	GO:0051788	5	0.434
organelle membrane fusion	GO:0090174	1	0.418
protein modification by small protein conjugation	GO:0032446	187	0.342
membrane organization	GO:0061024	245	0.300
protein catabolic process	GO:0030163	221	0.256
protein modification by small protein conjugation or removal	GO:0070647	207	0.228
intracellular protein transport	GO:0006886	204	0.215
cytoplasmic transport	GO:0016482	234	0.206
macroautophagy	GO:0016236	21	0.198
cellular protein catabolic process	GO:0044257	155	0.190
protein localization to organelle	GO:0033365	185	0.183
proteasomal protein catabolic process	GO:0010498	98	0.163
macromolecule catabolic process	GO:0009057	281	0.151
organelle fusion	GO:0048284	28	0.143
protein ubiquitination	GO:0016567	171	0.143
cellular response to cadmium ion	GO:0071276	3	0.132
proteolysis involved in cellular protein catabolic process	GO:0051603	147	0.131
modification dependent protein catabolic process	GO:0019941	133	0.123
modification dependent macromolecule catabolic process	GO:0043632	133	0.120
purine ribonucleotide metabolic process	GO:0009150	290	0.117
translesion synthesis	GO:0019985	1	0.116
protein localization to nucleus	GO:0034504	121	0.104
nucleotide metabolic process	GO:0009117	332	0.103
organelle disassembly	GO:1903008	2	0.092
glycosyl compound metabolic process	GO:1901657	246	0.091
meiotic cell cycle	GO:0051321	122	0.089
ubiquitin dependent protein catabolic process	GO:0006511	129	0.088
histone modification	GO:0016570	159	0.085
regulation of protein localization	GO:0032880	231	0.085
peptidyl amino acid modification	GO:0018193	336	0.081
cellular macromolecule catabolic process	GO:0044265	206	0.080
regulation of intracellular protein transport	GO:0033157	82	0.076
chromosome segregation	GO:0007059	48	0.075
positive regulation of protein modification process	GO:0031401	299	0.070
misfolded protein transport	GO:0070843	1	0.070
male gamete generation	GO:0048232	285	0.067
carbohydrate metabolic process	GO:0005975	230	0.061
covalent chromatin modification	GO:0016569	163	0.061
apoptotic signaling pathway	GO:0097190	306	0.060
er associated ubiquitin dependent protein catabolic process	GO:0030433	10	0.060
cellular response to external stimulus	GO:0071496	88	0.059
response to nutrient levels	GO:0031667	109	0.059
regulation of protein targeting	GO:1903533	61	0.059
response to extracellular stimulus	GO:0009991	127	0.057
regulation of cellular catabolic process	GO:0031329	242	0.057
autophagy	GO:0006914	45	0.056
carbohydrate derivative biosynthetic process	GO:1901137	183	0.055
negative regulation of cellular protein metabolic process	GO:0032269	247	0.054
cellular response to nutrient levels	GO:0031669	64	0.054
protein processing	GO:0016485	163	0.053
response to endoplasmic reticulum stress	GO:0034976	53	0.053
regulation of protein localization to nucleus	GO:1900180	60	0.053
pole plasm assembly	GO:0007315	2	0.052
ribonucleotide metabolic process	GO:0009259	291	0.051
cellular response to starvation	GO:0009267	57	0.051
cellular response to dna damage stimulus	GO:0006974	207	0.051
cellular response to extracellular stimulus	GO:0031668	81	0.051
nucleoside phosphate metabolic process	GO:0006753	338	0.050
meiotic nuclear division	GO:0007126	115	0.049
negative regulation of protein metabolic process	GO:0051248	282	0.049
positive regulation of proteasomal ubiquitin dependent protein catabolic process	GO:0032436	23	0.048
posttranscriptional regulation of gene expression	GO:0010608	155	0.048
nucleobase containing small molecule metabolic process	GO:0055086	352	0.048
protein oligomerization	GO:0051259	67	0.048
regulation of organelle organization	GO:0033043	289	0.047
single organism nuclear import	GO:1902593	95	0.046
nucleoside metabolic process	GO:0009116	246	0.046
dephosphorylation	GO:0016311	129	0.045
protein maturation	GO:0051604	176	0.044
proteasome mediated ubiquitin dependent protein catabolic process	GO:0043161	88	0.043
membrane invagination	GO:0010324	17	0.043
regulation of proteolysis involved in cellular protein catabolic process	GO:1903050	56	0.043
establishment of organelle localization	GO:0051656	122	0.041
regulation of protein transport	GO:0051223	163	0.041
striated muscle tissue development	GO:0014706	293	0.040
spermatogenesis	GO:0007283	284	0.040
positive regulation of chromatin modification	GO:1903310	28	0.040
regulation of histone modification	GO:0031056	56	0.039
exocytosis	GO:0006887	121	0.039
positive regulation of protein phosphorylation	GO:0001934	242	0.039
nucleoside triphosphate metabolic process	GO:0009141	230	0.039
maintenance of location	GO:0051235	89	0.039
positive regulation of apoptotic process	GO:0043065	217	0.038
purine containing compound metabolic process	GO:0072521	311	0.038
purine ribonucleoside triphosphate metabolic process	GO:0009205	220	0.038
cellular ketone metabolic process	GO:0042180	84	0.038
organelle fission	GO:0048285	170	0.037
positive regulation of protein localization to nucleus	GO:1900182	30	0.037
regulation of cellular protein catabolic process	GO:1903362	61	0.037
mitotic cell cycle	GO:0000278	195	0.036
protein import into nucleus	GO:0006606	95	0.036
organic cyclic compound catabolic process	GO:1901361	295	0.036
developmental maturation	GO:0021700	193	0.036
regulation of transferase activity	GO:0051338	263	0.035
nucleoside phosphate catabolic process	GO:1901292	222	0.035
regulation of chromosome organization	GO:0033044	83	0.035
ribose phosphate metabolic process	GO:0019693	291	0.035
maternal determination of anterior posterior axis embryo	GO:0008358	2	0.035
protein targeting	GO:0006605	143	0.035
purine nucleoside triphosphate catabolic process	GO:0009146	203	0.035
regulation of protein modification by small protein conjugation or removal	GO:1903320	57	0.034
carbohydrate derivative catabolic process	GO:1901136	231	0.034
cellular response to inorganic substance	GO:0071241	37	0.033
heterocycle catabolic process	GO:0046700	280	0.033
organelle localization	GO:0051640	179	0.033
oocyte anterior posterior axis specification	GO:0007314	2	0.033
metaphase plate congression	GO:0051310	2	0.033
purine nucleotide metabolic process	GO:0006163	302	0.033
protein import	GO:0017038	101	0.033
amine metabolic process	GO:0009308	45	0.032
attachment of spindle microtubules to kinetochore	GO:0008608	4	0.032
regulation of transcription factor import into nucleus	GO:0042990	24	0.032
positive regulation of cell death	GO:0010942	224	0.032
chromatin modification	GO:0016568	187	0.032
chromatin organization	GO:0006325	206	0.032
regulation of protein ubiquitination	GO:0031396	52	0.031
response to starvation	GO:0042594	65	0.031
establishment of protein localization to organelle	GO:0072594	118	0.031
rna interference	GO:0016246	2	0.031
organonitrogen compound catabolic process	GO:1901565	264	0.030
positive regulation of programmed cell death	GO:0043068	218	0.030
nuclear transport	GO:0051169	139	0.029
protein glycosylation	GO:0006486	55	0.029
purine ribonucleoside metabolic process	GO:0046128	241	0.029
glycosylation	GO:0070085	62	0.028
regulation of endopeptidase activity	GO:0052548	89	0.028
regulation of chromatin organization	GO:1902275	57	0.028
positive regulation of proteolysis involved in cellular protein catabolic process	GO:1903052	31	0.028
posttranscriptional gene silencing	GO:0016441	10	0.028
ribonucleoside triphosphate catabolic process	GO:0009203	199	0.027
regulation of chromatin modification	GO:1903308	57	0.027
regionalization	GO:0003002	337	0.027
response to inorganic substance	GO:0010035	96	0.027
positive regulation of cellular amino acid metabolic process	GO:0045764	3	0.027
microtubule cytoskeleton organization involved in mitosis	GO:1902850	4	0.026
synaptic transmission	GO:0007268	329	0.026
oocyte axis specification	GO:0007309	2	0.026
positive regulation of organelle organization	GO:0010638	128	0.026
skeletal system development	GO:0001501	356	0.026
mitotic sister chromatid segregation	GO:0000070	14	0.026
protein complex disassembly	GO:0043241	40	0.026
regulation of proteolysis	GO:0030162	164	0.026
positive regulation of proteolysis	GO:0045862	85	0.026
positive regulation of intracellular transport	GO:0032388	70	0.026
purine nucleoside metabolic process	GO:0042278	241	0.026
engulfment of apoptotic cell	GO:0043652	3	0.025
neuron apoptotic process	GO:0051402	142	0.025
atp metabolic process	GO:0046034	75	0.025
positive regulation of endopeptidase activity	GO:0010950	43	0.025
action potential	GO:0001508	78	0.025
positive regulation of cellular catabolic process	GO:0031331	148	0.025
cellular response to topologically incorrect protein	GO:0035967	25	0.024
negative regulation of cellular component organization	GO:0051129	194	0.024
regulation of cytoplasmic transport	GO:1903649	112	0.024
golgi vesicle transport	GO:0048193	30	0.024
regulation of proteasomal ubiquitin dependent protein catabolic process	GO:0032434	40	0.024
cartilage development	GO:0051216	140	0.024
muscle tissue development	GO:0060537	308	0.024
nucleocytoplasmic transport	GO:0006913	139	0.024
activation of cysteine type endopeptidase activity	GO:0097202	27	0.024
vacuole organization	GO:0007033	38	0.024
cellular nitrogen compound catabolic process	GO:0044270	280	0.024
regulation of cell migration	GO:0030334	219	0.023
mitotic cell cycle process	GO:1903047	159	0.023
cation transport	GO:0006812	399	0.023
positive regulation of peptidase activity	GO:0010952	49	0.023
ribonucleoside monophosphate metabolic process	GO:0009161	80	0.023
ribonucleoside triphosphate metabolic process	GO:0009199	220	0.023
response to radiation	GO:0009314	165	0.023
negative regulation of cell proliferation	GO:0008285	296	0.023
regulation of protein maturation	GO:1903317	96	0.023
microtubule based process	GO:0007017	236	0.023
ribonucleotide catabolic process	GO:0009261	208	0.023
macromolecular complex disassembly	GO:0032984	43	0.023
regulation of cellular component biogenesis	GO:0044087	181	0.022
intrinsic apoptotic signaling pathway	GO:0097193	132	0.022
regulation of establishment of protein localization	GO:0070201	181	0.022
positive regulation of protein transport	GO:0051222	93	0.022
dna metabolic process	GO:0006259	303	0.022
ribonucleoside metabolic process	GO:0009119	245	0.022
regulation of cellular amine metabolic process	GO:0033238	20	0.021
nucleoside catabolic process	GO:0009164	206	0.021
regulation of protein kinase activity	GO:0045859	232	0.021
cellular amine metabolic process	GO:0044106	44	0.021
nucleoside triphosphate catabolic process	GO:0009143	205	0.021
protein modification by small protein removal	GO:0070646	21	0.021
histone ubiquitination	GO:0016574	10	0.021
gene silencing	GO:0016458	38	0.021
aromatic compound catabolic process	GO:0019439	286	0.020
response to topologically incorrect protein	GO:0035966	25	0.020
multicellular organism growth	GO:0035264	161	0.020
regulation of peptidase activity	GO:0052547	96	0.020
glycoprotein metabolic process	GO:0009100	116	0.020
negative regulation of intracellular signal transduction	GO:1902532	167	0.020
response to uv	GO:0009411	44	0.020
purine ribonucleotide catabolic process	GO:0009154	208	0.019
positive regulation of dna templated transcription elongation	GO:0032786	2	0.019
response to cadmium ion	GO:0046686	8	0.019
regulation of hydrolase activity	GO:0051336	246	0.019
transmembrane transport	GO:0055085	412	0.019
regulation of cellular amino acid metabolic process	GO:0006521	5	0.019
glycosyl compound catabolic process	GO:1901658	206	0.019
regulation of protein deubiquitination	GO:0090085	1	0.018
protein ubiquitination involved in ubiquitin dependent protein catabolic process	GO:0042787	25	0.018
gene silencing by rna	GO:0031047	19	0.018
canonical wnt signaling pathway	GO:0060070	130	0.018
cation transmembrane transport	GO:0098655	266	0.018
guanosine containing compound metabolic process	GO:1901068	144	0.018
positive regulation of cellular amine metabolic process	GO:0033240	5	0.018
wnt signaling pathway	GO:0016055	188	0.018
positive regulation of protein kinase activity	GO:0045860	144	0.018
nuclear import	GO:0051170	95	0.017
positive regulation of intracellular protein transport	GO:0090316	42	0.017
atp catabolic process	GO:0006200	55	0.017
regulation of protein complex assembly	GO:0043254	83	0.017
regulation of kinase activity	GO:0043549	249	0.017
negative regulation of protein maturation	GO:1903318	79	0.017
reactive oxygen species metabolic process	GO:0072593	84	0.017
protein homooligomerization	GO:0051260	43	0.017
positive regulation of chromosome organization	GO:2001252	33	0.016
misfolded or incompletely synthesized protein catabolic process	GO:0006515	4	0.016
positive regulation of protein complex assembly	GO:0031334	45	0.016
purine ribonucleoside triphosphate catabolic process	GO:0009207	199	0.016
regulation of cellular ketone metabolic process	GO:0010565	66	0.016
cellular response to organonitrogen compound	GO:0071417	145	0.016
protein deubiquitination	GO:0016579	19	0.016
regulation of protein catabolic process	GO:0042176	108	0.016
regulation of protein serine threonine kinase activity	GO:0071900	157	0.016
purine nucleoside catabolic process	GO:0006152	205	0.016
positive regulation of growth	GO:0045927	104	0.015
cellular amino acid metabolic process	GO:0006520	103	0.015
rna catabolic process	GO:0006401	29	0.015
cellular protein complex assembly	GO:0043623	116	0.015
response to light stimulus	GO:0009416	135	0.015
germ cell development	GO:0007281	185	0.015
regulation of cysteine type endopeptidase activity	GO:2000116	65	0.015
male meiosis	GO:0007140	37	0.015
purine ribonucleoside catabolic process	GO:0046130	205	0.015
lipid localization	GO:0010876	126	0.015
regulation of protein import into nucleus	GO:0042306	52	0.015
purine nucleoside triphosphate metabolic process	GO:0009144	226	0.015
cellular response to metal ion	GO:0071248	31	0.015
stem cell differentiation	GO:0048863	268	0.014
protein targeting to er	GO:0045047	2	0.014
positive regulation of protein serine threonine kinase activity	GO:0071902	106	0.014
positive regulation of kinase activity	GO:0033674	155	0.014
positive regulation of histone modification	GO:0031058	28	0.014
double strand break repair	GO:0006302	48	0.014
dna repair	GO:0006281	107	0.014
muscle cell differentiation	GO:0042692	261	0.014
positive regulation of cellular component biogenesis	GO:0044089	94	0.014
organophosphate catabolic process	GO:0046434	232	0.014
mapk cascade	GO:0000165	281	0.014
regulation of intrinsic apoptotic signaling pathway	GO:2001242	61	0.014
response to metal ion	GO:0010038	47	0.014
transmembrane receptor protein serine threonine kinase signaling pathway	GO:0007178	194	0.014
negative regulation of protein modification process	GO:0031400	163	0.014
positive regulation of transcription elongation from rna polymerase ii promoter	GO:0032968	2	0.014
positive regulation of transferase activity	GO:0051347	167	0.014
sequestering of calcium ion	GO:0051208	18	0.014
stem cell development	GO:0048864	219	0.014
regulation of mapk cascade	GO:0043408	248	0.014
sensory perception	GO:0007600	245	0.013
cell type specific apoptotic process	GO:0097285	268	0.013
organic hydroxy compound metabolic process	GO:1901615	203	0.013
purine ribonucleoside monophosphate metabolic process	GO:0009167	80	0.013
nitrogen compound transport	GO:0071705	271	0.013
amp metabolic process	GO:0046033	4	0.013
aggresome assembly	GO:0070842	2	0.013
cellular lipid metabolic process	GO:0044255	323	0.013
purine nucleoside monophosphate metabolic process	GO:0009126	81	0.013
regulation of apoptotic signaling pathway	GO:2001233	197	0.013
negative regulation of phosphate metabolic process	GO:0045936	184	0.013
negative regulation of immune system process	GO:0002683	209	0.013
regulation of cell cycle	GO:0051726	281	0.013
regulation of cell motility	GO:2000145	236	0.013
establishment of protein localization to membrane	GO:0090150	54	0.013
stress activated mapk cascade	GO:0051403	80	0.013
regulation of wnt signaling pathway	GO:0030111	123	0.013
g protein coupled receptor signaling pathway	GO:0007186	243	0.013
neuron death	GO:0070997	154	0.012
peptide transport	GO:0015833	133	0.012
ribonucleoside catabolic process	GO:0042454	206	0.012
connective tissue development	GO:0061448	179	0.012
regulation of vesicle mediated transport	GO:0060627	139	0.012
cellular response to oxidative stress	GO:0034599	76	0.012
regulation of androgen receptor signaling pathway	GO:0060765	3	0.012
regulation of rna polymerase ii transcriptional preinitiation complex assembly	GO:0045898	2	0.012
regulation of protein ubiquitination involved in ubiquitin dependent protein catabolic process	GO:2000058	14	0.012
oogenesis	GO:0048477	56	0.012
organic anion transport	GO:0015711	137	0.012
regulation of cytokine production	GO:0001817	266	0.012
protein methylation	GO:0006479	81	0.012
cardiac muscle tissue development	GO:0048738	130	0.012
regulation of secretion	GO:0051046	274	0.012
cell adhesion	GO:0007155	329	0.012
protein k63 linked deubiquitination	GO:0070536	1	0.011
negative regulation of neuron apoptotic process	GO:0043524	92	0.011
er to golgi vesicle mediated transport	GO:0006888	11	0.011
positive regulation of protein modification by small protein conjugation or removal	GO:1903322	30	0.011
peptidyl asparagine modification	GO:0018196	1	0.011
skeletal muscle organ development	GO:0060538	163	0.011
sister chromatid segregation	GO:0000819	20	0.011
intracellular mrna localization	GO:0008298	4	0.011
nucleoside monophosphate metabolic process	GO:0009123	85	0.011
regulation of cellular response to stress	GO:0080135	159	0.011
response to organic cyclic compound	GO:0014070	198	0.011
response to organonitrogen compound	GO:0010243	246	0.011
positive regulation of cysteine type endopeptidase activity involved in apoptotic process	GO:0043280	36	0.011
response to hydrogen peroxide	GO:0042542	32	0.011
cytokine production	GO:0001816	319	0.011
apoptotic mitochondrial changes	GO:0008637	48	0.011
divalent inorganic cation transport	GO:0072511	178	0.011
guanosine containing compound catabolic process	GO:1901069	144	0.011
maintenance of location in cell	GO:0051651	24	0.011
trna wobble base modification	GO:0002097	2	0.011
positive regulation of hydrolase activity	GO:0051345	148	0.011
mitotic nuclear division	GO:0007067	48	0.011
regulation of homeostatic process	GO:0032844	182	0.011
monocarboxylic acid metabolic process	GO:0032787	191	0.011
transmission of nerve impulse	GO:0019226	76	0.011
leukocyte differentiation	GO:0002521	342	0.011
intra golgi vesicle mediated transport	GO:0006891	1	0.011
ossification	GO:0001503	216	0.011
vesicle organization	GO:0016050	60	0.011
cellular homeostasis	GO:0019725	240	0.011
regulation of neuron apoptotic process	GO:0043523	122	0.010
neuronal action potential	GO:0019228	54	0.010
regulation of fat cell differentiation	GO:0045598	81	0.010
regulation of translation	GO:0006417	71	0.010
dna templated transcriptional preinitiation complex assembly	GO:0070897	4	0.010
homeostasis of number of cells	GO:0048872	210	0.010
regulation of cell projection organization	GO:0031344	206	0.010
negative regulation of kinase activity	GO:0033673	81	0.010
stress activated protein kinase signaling cascade	GO:0031098	81	0.010
vesicle localization	GO:0051648	86	0.010
protein targeting to membrane	GO:0006612	20	0.010
cellular chemical homeostasis	GO:0055082	215	0.010
jnk cascade	GO:0007254	72	0.010
rna processing	GO:0006396	105	0.010
activation of cysteine type endopeptidase activity involved in apoptotic process	GO:0006919	27	0.010

Ufd1l disease predictions

Disease predictions are made from cross-annotation of human disease genes to the identified functional analogs in mouse and predicted with the mouse functional network.

Disease	DO term ID	Probability
central nervous system disease	DOID:331	0.117
nervous system disease	DOID:863	0.117
disease of anatomical entity	DOID:7	0.117
musculoskeletal system disease	DOID:17	0.027
neurodegenerative disease	DOID:1289	0.026
motor neuron disease	DOID:231	0.016
amyotrophic lateral sclerosis	DOID:332	0.014

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