IMP: Integrative Multi-species Prediction

Mus musculus

11 known processes

Klk1b9

kallikrein 1-related peptidase b9

(Aliases: mGk-9,Klk9,Egfbp-3,Egfbp3)

Ensembl: ENSMUSG00000059042
Entrez: 13648
UniProtKB: P15949

Process Predictions
Disease Predictions

Klk1b9 biological process predictions

Show only novel predictionsHighlight processes of functional analogs

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Biological process	GO term ID	Process size	Probability	Func Analog Org
kinin cascade	GO:0002254	2	0.880	Mouse
tissue kallikrein kinin cascade	GO:0002255	1	0.875	Mouse
left ventricular cardiac muscle tissue morphogenesis	GO:0003220	2	0.870	Mouse
negative regulation of neuron projection regeneration	GO:0070571	3	0.781	Mouse
positive regulation of vasoconstriction	GO:0045907	4	0.779	Rat
protein activation cascade	GO:0072376	19	0.736	Mouse
binding of sperm to zona pellucida	GO:0007339	34	0.539	Mouse
positive regulation of lipid kinase activity	GO:0090218	11	0.419	Mouse
bradykinin biosynthetic process	GO:0002936	1	0.360	Mouse
phospholipid metabolic process	GO:0006644	87	0.349	Mouse
protein maturation	GO:0051604	176	0.332
regulation of membrane potential	GO:0042391	192	0.328
brain renin angiotensin system	GO:0002035	5	0.322	Mouse
circulatory system process	GO:0003013	197	0.319	Mouse Rat
sperm egg recognition	GO:0035036	37	0.305	Mouse
peptide metabolic process	GO:0006518	46	0.277	Mouse
striated muscle contraction	GO:0006941	45	0.276	Mouse
cellular amide metabolic process	GO:0043603	58	0.273	Mouse
vasodilation	GO:0042311	28	0.266	Mouse
muscle contraction	GO:0006936	101	0.265	Mouse
action potential	GO:0001508	78	0.262
keratinocyte proliferation	GO:0043616	21	0.260	Mouse
cell cell recognition	GO:0009988	44	0.258	Mouse
organonitrogen compound biosynthetic process	GO:1901566	192	0.242	Mouse
regulation of phosphatidylinositol 3 kinase activity	GO:0043551	14	0.236	Mouse
inflammatory response	GO:0006954	244	0.231	Mouse
regulation of kinase activity	GO:0043549	249	0.230	Mouse
heart process	GO:0003015	94	0.229	Mouse
regulation of tube size	GO:0035150	57	0.221	Mouse Rat
heart morphogenesis	GO:0003007	178	0.216	Mouse
protein catabolic process	GO:0030163	221	0.213	Mouse
regulation of systemic arterial blood pressure by renin angiotensin	GO:0003081	20	0.211	Mouse
neurological system process involved in regulation of systemic arterial blood pressure	GO:0001976	18	0.210	Mouse
cognition	GO:0050890	149	0.208	Mouse
heart contraction	GO:0060047	93	0.205	Mouse
zymogen activation	GO:0031638	41	0.204
cellular lipid metabolic process	GO:0044255	323	0.198	Mouse
negative regulation of neuron projection development	GO:0010977	50	0.197	Mouse
ensheathment of neurons	GO:0007272	76	0.194	Mouse
blood circulation	GO:0008015	195	0.194	Mouse Rat
regulation of neuron projection development	GO:0010975	169	0.193	Mouse
macromolecule catabolic process	GO:0009057	281	0.192	Mouse
regulation of myelination	GO:0031641	20	0.185	Mouse
transmission of nerve impulse	GO:0019226	76	0.185
protein processing	GO:0016485	163	0.182
memory	GO:0007613	58	0.179	Mouse
learning or memory	GO:0007611	148	0.173	Mouse
regulation of blood vessel size	GO:0050880	56	0.170	Mouse Rat
regulation of blood pressure	GO:0008217	93	0.169	Mouse
regulation of system process	GO:0044057	200	0.168	Mouse Rat
regulation of systemic arterial blood pressure by hormone	GO:0001990	25	0.167	Mouse
striated muscle tissue development	GO:0014706	293	0.165	Mouse
regulation of systemic arterial blood pressure	GO:0003073	61	0.161	Mouse
small gtpase mediated signal transduction	GO:0007264	97	0.160	Mouse
regulation of transferase activity	GO:0051338	263	0.159	Mouse
neuronal action potential	GO:0019228	54	0.157
fertilization	GO:0009566	127	0.156	Mouse
positive regulation of phosphatidylinositol 3 kinase activity	GO:0043552	11	0.151	Mouse
regulation of blood volume by renin angiotensin	GO:0002016	7	0.149	Mouse
regulation of blood circulation	GO:1903522	93	0.145	Rat
regulation of neuron projection regeneration	GO:0070570	7	0.143	Mouse
positive regulation of transferase activity	GO:0051347	167	0.140	Mouse
cardiac chamber morphogenesis	GO:0003206	93	0.134	Mouse
multicellular organismal signaling	GO:0035637	91	0.133
cardiac muscle contraction	GO:0060048	32	0.132	Mouse
regulation of lipid kinase activity	GO:0043550	14	0.130	Mouse
cardiac left ventricle morphogenesis	GO:0003214	9	0.125	Mouse
transmembrane transport	GO:0055085	412	0.118
cardiac ventricle morphogenesis	GO:0003208	50	0.117	Mouse
cardiac ventricle development	GO:0003231	83	0.110	Mouse
synapse organization	GO:0050808	125	0.108	Mouse
peptide biosynthetic process	GO:0043043	11	0.104	Mouse
regulation of cell projection organization	GO:0031344	206	0.101	Mouse
muscle system process	GO:0003012	141	0.101	Mouse
extracellular structure organization	GO:0043062	148	0.101	Mouse
muscle tissue development	GO:0060537	308	0.096	Mouse
myelination	GO:0042552	74	0.096	Mouse
cardiac muscle tissue morphogenesis	GO:0055008	44	0.096	Mouse
endocrine process	GO:0050886	39	0.095	Mouse
single fertilization	GO:0007338	82	0.090	Mouse
extracellular matrix organization	GO:0030198	147	0.088	Mouse
cell recognition	GO:0008037	83	0.086	Mouse
regulation of neuron differentiation	GO:0045664	281	0.086	Mouse
ion transmembrane transport	GO:0034220	361	0.083
negative regulation of response to wounding	GO:1903035	77	0.080	Mouse
cation transport	GO:0006812	399	0.079
negative regulation of cell projection organization	GO:0031345	56	0.079	Mouse
cardiac muscle tissue development	GO:0048738	130	0.077	Mouse
regulation of response to wounding	GO:1903034	189	0.075	Mouse
positive regulation of kinase activity	GO:0033674	155	0.075	Mouse
nitrogen compound transport	GO:0071705	271	0.074
regulation of anatomical structure size	GO:0090066	178	0.074	Mouse Rat
axon ensheathment	GO:0008366	76	0.071	Mouse
regulation of cellular response to stress	GO:0080135	159	0.070	Mouse
regulation of lipid metabolic process	GO:0019216	118	0.064	Mouse
regulation of systemic arterial blood pressure mediated by a chemical signal	GO:0003044	33	0.063	Mouse
cardiac chamber development	GO:0003205	108	0.062	Mouse
odontogenesis	GO:0042476	78	0.062	Mouse
negative regulation of cellular component organization	GO:0051129	194	0.060	Mouse
muscle tissue morphogenesis	GO:0060415	53	0.060	Mouse
negative regulation of neurological system process	GO:0031645	7	0.060	Mouse
ventricular cardiac muscle tissue morphogenesis	GO:0055010	32	0.058	Mouse
regulation of neurological system process	GO:0031644	22	0.058	Mouse
positive regulation of blood circulation	GO:1903524	22	0.056	Rat
epithelial cell proliferation	GO:0050673	174	0.055	Mouse
vascular process in circulatory system	GO:0003018	62	0.055	Mouse Rat
ventricular cardiac muscle tissue development	GO:0003229	38	0.054	Mouse
vasoconstriction	GO:0042310	27	0.053	Rat
carbohydrate derivative biosynthetic process	GO:1901137	183	0.052
positive regulation of lipid metabolic process	GO:0045834	40	0.050	Mouse
amine metabolic process	GO:0009308	45	0.047
nucleotide metabolic process	GO:0009117	332	0.043
odontogenesis of dentin containing tooth	GO:0042475	66	0.043	Mouse
negative regulation of nervous system development	GO:0051961	156	0.042	Mouse
spermatogenesis	GO:0007283	284	0.042
sterol homeostasis	GO:0055092	45	0.041
regulation of body fluid levels	GO:0050878	162	0.041
synaptic transmission	GO:0007268	329	0.039	Mouse
male gamete generation	GO:0048232	285	0.038
maintenance of location	GO:0051235	89	0.037
lipid localization	GO:0010876	126	0.036
cellular amino acid metabolic process	GO:0006520	103	0.035
organic hydroxy compound transport	GO:0015850	93	0.034
nucleobase containing small molecule metabolic process	GO:0055086	352	0.034
amide transport	GO:0042886	138	0.033
acute inflammatory response	GO:0002526	41	0.032	Mouse
cellular amine metabolic process	GO:0044106	44	0.032
negative regulation of myelination	GO:0031642	6	0.031	Mouse
regulation of ion transport	GO:0043269	215	0.031
regulation of cellular amine metabolic process	GO:0033238	20	0.030
cellular ketone metabolic process	GO:0042180	84	0.030
monocarboxylic acid metabolic process	GO:0032787	191	0.029
amide biosynthetic process	GO:0043604	16	0.029	Mouse
amelogenesis	GO:0097186	12	0.029	Mouse
organic cyclic compound catabolic process	GO:1901361	295	0.028
negative regulation of cholesterol transport	GO:0032375	4	0.028
cation transmembrane transport	GO:0098655	266	0.028
regeneration	GO:0031099	38	0.028	Mouse
blastocyst development	GO:0001824	80	0.028
organic acid biosynthetic process	GO:0016053	86	0.028
negative regulation of neuron differentiation	GO:0045665	101	0.026	Mouse
membrane organization	GO:0061024	245	0.026
positive regulation of cell death	GO:0010942	224	0.026
small molecule biosynthetic process	GO:0044283	132	0.026
inorganic cation transmembrane transport	GO:0098662	207	0.026
response to organonitrogen compound	GO:0010243	246	0.026
negative regulation of cell development	GO:0010721	169	0.025	Mouse
nucleoside phosphate metabolic process	GO:0006753	338	0.025
endomembrane system organization	GO:0010256	147	0.025
skin development	GO:0043588	220	0.025
peptide secretion	GO:0002790	114	0.025
sensory perception of sound	GO:0007605	97	0.025
oxidation reduction process	GO:0055114	342	0.025
purine nucleotide metabolic process	GO:0006163	302	0.025
organic anion transport	GO:0015711	137	0.025
sterol transport	GO:0015918	38	0.025
negative regulation of protein metabolic process	GO:0051248	282	0.024
carbohydrate metabolic process	GO:0005975	230	0.023
organophosphate biosynthetic process	GO:0090407	122	0.022
cholesterol transport	GO:0030301	38	0.022
cellular homeostasis	GO:0019725	240	0.022
regulation of vasoconstriction	GO:0019229	14	0.022	Rat
purine ribonucleotide metabolic process	GO:0009150	290	0.022
multicellular organism growth	GO:0035264	161	0.021
lipid transport	GO:0006869	98	0.021
respiratory system development	GO:0060541	190	0.021
regulation of secretion	GO:0051046	274	0.021
response to organic cyclic compound	GO:0014070	198	0.021
organelle fission	GO:0048285	170	0.021
glucose homeostasis	GO:0042593	128	0.021
ribose phosphate metabolic process	GO:0019693	291	0.020
carboxylic acid biosynthetic process	GO:0046394	86	0.020
purine containing compound metabolic process	GO:0072521	311	0.020
regulation of cytokine production	GO:0001817	266	0.020
response to extracellular stimulus	GO:0009991	127	0.020
divalent metal ion transport	GO:0070838	172	0.020
nucleoside metabolic process	GO:0009116	246	0.020
positive regulation of programmed cell death	GO:0043068	218	0.020
neuron projection regeneration	GO:0031102	14	0.020	Mouse
inorganic ion transmembrane transport	GO:0098660	234	0.019
wnt signaling pathway	GO:0016055	188	0.019
axon regeneration	GO:0031103	12	0.019	Mouse
negative regulation of cellular protein metabolic process	GO:0032269	247	0.019
regulation of secretion by cell	GO:1903530	249	0.019
spermatid development	GO:0007286	108	0.019
negative regulation of immune system process	GO:0002683	209	0.019
myeloid cell differentiation	GO:0030099	233	0.018
regulation of cell activation	GO:0050865	289	0.018
purine containing compound catabolic process	GO:0072523	213	0.018
regulation of cellular ketone metabolic process	GO:0010565	66	0.018
anion transport	GO:0006820	177	0.018
blastocyst growth	GO:0001832	23	0.018
negative regulation of cellular amine metabolic process	GO:0033239	1	0.018
negative regulation of protein modification process	GO:0031400	163	0.018
spermatid differentiation	GO:0048515	115	0.018
regulation of cellular amino acid metabolic process	GO:0006521	5	0.018
cellular response to lipid	GO:0071396	145	0.018
regulation of cell division	GO:0051302	76	0.018
homeostasis of number of cells	GO:0048872	210	0.017
ribonucleotide metabolic process	GO:0009259	291	0.017
lipid homeostasis	GO:0055088	63	0.017
reactive oxygen species metabolic process	GO:0072593	84	0.017
sphingolipid metabolic process	GO:0006665	45	0.017
negative regulation of sterol transport	GO:0032372	4	0.017
lipid biosynthetic process	GO:0008610	179	0.017
nuclear division	GO:0000280	158	0.017
sensory organ morphogenesis	GO:0090596	242	0.017
cytoplasmic transport	GO:0016482	234	0.017
peptide hormone secretion	GO:0030072	109	0.017
digestion	GO:0007586	40	0.017
aromatic compound catabolic process	GO:0019439	286	0.017
negative regulation of cellular amino acid metabolic process	GO:0045763	0	0.017
cellular calcium ion homeostasis	GO:0006874	119	0.017
regulation of intracellular transport	GO:0032386	159	0.016
peptide transport	GO:0015833	133	0.016
regulation of transmembrane transport	GO:0034762	128	0.016
intestinal epithelial structure maintenance	GO:0060729	4	0.016
striated muscle myosin thick filament assembly	GO:0071688	1	0.016
ribonucleoside metabolic process	GO:0009119	245	0.016
methylation	GO:0032259	134	0.016
inner cell mass cell proliferation	GO:0001833	15	0.016
cytokine production	GO:0001816	319	0.015
negative regulation of phosphorylation	GO:0042326	166	0.015
response to nutrient levels	GO:0031667	109	0.015
cholesterol homeostasis	GO:0042632	44	0.015
regulation of sterol transport	GO:0032371	17	0.015
regulation of synaptic growth at neuromuscular junction	GO:0008582	4	0.015
myeloid leukocyte differentiation	GO:0002573	119	0.015
nucleoside phosphate catabolic process	GO:1901292	222	0.015
sulfur compound metabolic process	GO:0006790	100	0.015
sperm motility	GO:0030317	47	0.015
glutathione metabolic process	GO:0006749	16	0.015
g protein coupled receptor signaling pathway	GO:0007186	243	0.015
germ cell development	GO:0007281	185	0.015
c21 steroid hormone biosynthetic process	GO:0006700	3	0.015
regulation of apoptotic signaling pathway	GO:2001233	197	0.014
amino acid transport	GO:0006865	61	0.014
regulation of metal ion transport	GO:0010959	106	0.014
cellular nitrogen compound catabolic process	GO:0044270	280	0.014
multicellular organismal homeostasis	GO:0048871	164	0.014
heterocycle catabolic process	GO:0046700	280	0.014
alpha amino acid metabolic process	GO:1901605	59	0.014
gland development	GO:0048732	330	0.014
nucleoside triphosphate metabolic process	GO:0009141	230	0.014
regulation of peptide transport	GO:0090087	91	0.014
nucleoside catabolic process	GO:0009164	206	0.013
regulation of lymphocyte activation	GO:0051249	240	0.013
regulation of protein localization	GO:0032880	231	0.013
regulation of defense response	GO:0031347	233	0.013
organic acid transport	GO:0015849	101	0.013
meiotic cell cycle process	GO:1903046	77	0.013
sequestering of metal ion	GO:0051238	19	0.013
skeletal system development	GO:0001501	356	0.013
negative regulation of protein phosphorylation	GO:0001933	126	0.013
positive regulation of potassium ion transport	GO:0043268	3	0.013
divalent inorganic cation homeostasis	GO:0072507	138	0.013
hormone secretion	GO:0046879	128	0.013
intracellular protein transport	GO:0006886	204	0.013
metanephric glomerulus development	GO:0072224	13	0.013
innate immune response	GO:0045087	157	0.013
purine nucleoside metabolic process	GO:0042278	241	0.013
regulation of interleukin 8 production	GO:0032677	3	0.013
eye photoreceptor cell differentiation	GO:0001754	41	0.013
chromatin modification	GO:0016568	187	0.013
modification dependent protein catabolic process	GO:0019941	133	0.013
purine ribonucleoside metabolic process	GO:0046128	241	0.013
body fluid secretion	GO:0007589	53	0.013
carbohydrate derivative catabolic process	GO:1901136	231	0.013
leukocyte differentiation	GO:0002521	342	0.013
positive regulation of cellular amine metabolic process	GO:0033240	5	0.013
ceramide metabolic process	GO:0006672	31	0.012
ubiquitin dependent protein catabolic process	GO:0006511	129	0.012
leukocyte migration	GO:0050900	124	0.012
ribonucleoside monophosphate metabolic process	GO:0009161	80	0.012
proteolysis involved in cellular protein catabolic process	GO:0051603	147	0.012
developmental maturation	GO:0021700	193	0.012
purine nucleoside triphosphate catabolic process	GO:0009146	203	0.012
cellular chemical homeostasis	GO:0055082	215	0.012
regulation of peptide hormone secretion	GO:0090276	75	0.012
stem cell differentiation	GO:0048863	268	0.012
nucleotide catabolic process	GO:0009166	217	0.012
regulation of mapk cascade	GO:0043408	248	0.012
exocytosis	GO:0006887	121	0.012
negative regulation of intracellular signal transduction	GO:1902532	167	0.012
regulation of purine nucleotide metabolic process	GO:1900542	169	0.012
morphogenesis of a polarized epithelium	GO:0001738	37	0.012
transmembrane receptor protein serine threonine kinase signaling pathway	GO:0007178	194	0.012
morphogenesis of a branching epithelium	GO:0061138	193	0.012
detection of molecule of bacterial origin	GO:0032490	2	0.012
regulation of protein catabolic process	GO:0042176	108	0.012
insulin secretion	GO:0030073	89	0.012
cellular macromolecule catabolic process	GO:0044265	206	0.012
cellular response to organonitrogen compound	GO:0071417	145	0.012
tissue homeostasis	GO:0001894	115	0.012
response to acid chemical	GO:0001101	111	0.012
coagulation	GO:0050817	78	0.012
regulation of hormone levels	GO:0010817	211	0.012
membrane lipid biosynthetic process	GO:0046467	32	0.012
progesterone metabolic process	GO:0042448	4	0.012
ribonucleoside triphosphate metabolic process	GO:0009199	220	0.011
alcohol metabolic process	GO:0006066	116	0.011
negative regulation of molecular function	GO:0044092	258	0.011
sequestering of calcium ion	GO:0051208	18	0.011
regulation of peptide secretion	GO:0002791	77	0.011
carboxylic acid transport	GO:0046942	100	0.011
plasma membrane organization	GO:0007009	90	0.011
purine nucleoside triphosphate metabolic process	GO:0009144	226	0.011
cholesterol efflux	GO:0033344	24	0.011
innate immune response in mucosa	GO:0002227	3	0.011
regulation of vesicle mediated transport	GO:0060627	139	0.011
positive regulation of apoptotic process	GO:0043065	217	0.011
cation homeostasis	GO:0055080	212	0.011
positive regulation of hydrolase activity	GO:0051345	148	0.011
ribonucleoside catabolic process	GO:0042454	206	0.011
digestive system development	GO:0055123	200	0.011
purine ribonucleoside triphosphate metabolic process	GO:0009205	220	0.011
nucleoside monophosphate metabolic process	GO:0009123	85	0.011
cytosolic calcium ion homeostasis	GO:0051480	70	0.011
organelle localization	GO:0051640	179	0.011
alpha amino acid biosynthetic process	GO:1901607	15	0.011
divalent inorganic cation transport	GO:0072511	178	0.011
carbohydrate homeostasis	GO:0033500	128	0.011
cellular protein catabolic process	GO:0044257	155	0.011
purine ribonucleoside monophosphate metabolic process	GO:0009167	80	0.011
icosanoid metabolic process	GO:0006690	33	0.011
organonitrogen compound catabolic process	GO:1901565	264	0.011
cellular component assembly involved in morphogenesis	GO:0010927	139	0.011
nucleoside phosphate biosynthetic process	GO:1901293	79	0.011
protein localization to nucleus	GO:0034504	121	0.011
cell maturation	GO:0048469	127	0.010
posttranscriptional regulation of gene expression	GO:0010608	155	0.010
organelle assembly	GO:0070925	177	0.010
fatty acid biosynthetic process	GO:0006633	41	0.010
rna interference	GO:0016246	2	0.010
purine nucleotide catabolic process	GO:0006195	211	0.010
inorganic anion transport	GO:0015698	43	0.010
cell type specific apoptotic process	GO:0097285	268	0.010
dna metabolic process	GO:0006259	303	0.010
anatomical structure homeostasis	GO:0060249	145	0.010
atp catabolic process	GO:0006200	55	0.010
negative regulation of phosphorus metabolic process	GO:0010563	184	0.010
myeloid cell homeostasis	GO:0002262	114	0.010
protein modification by small protein conjugation or removal	GO:0070647	207	0.010
retina development in camera type eye	GO:0060041	119	0.010
astrocyte fate commitment	GO:0060018	4	0.010
oligopeptide transmembrane transport	GO:0035672	4	0.010
regulation of proteolysis	GO:0030162	164	0.010
positive regulation of macrophage derived foam cell differentiation	GO:0010744	4	0.010
protein localization to organelle	GO:0033365	185	0.010
organophosphate catabolic process	GO:0046434	232	0.010
nucleotide biosynthetic process	GO:0009165	78	0.010
nucleocytoplasmic transport	GO:0006913	139	0.010
activation of immune response	GO:0002253	138	0.010
rho protein signal transduction	GO:0007266	32	0.010
positive regulation of protein kinase activity	GO:0045860	144	0.010
epithelial cell development	GO:0002064	159	0.010

Klk1b9 disease predictions

Disease predictions are made from cross-annotation of human disease genes to the identified functional analogs in mouse and predicted with the mouse functional network.

Disease	DO term ID	Probability
cancer	DOID:162	0.018
organ system cancer	DOID:0050686	0.018
disease of cellular proliferation	DOID:14566	0.018
disease of anatomical entity	DOID:7	0.013
nervous system disease	DOID:863	0.013
disease of metabolism	DOID:0014667	0.012
immune system disease	DOID:2914	0.012
connective tissue disease	DOID:65	0.011
musculoskeletal system disease	DOID:17	0.011
bone disease	DOID:0080001	0.011

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