IMP: Integrative Multi-species Prediction

Mus musculus

0 known processes

Klk1b8

kallikrein 1-related peptidase b8

(Aliases: Klk8,mGK-8,Nrpn,TADG14,MGC18615)

Ensembl: ENSMUSG00000063089
Entrez: 16624
UniProtKB: P07628

Process Predictions
Disease Predictions

Klk1b8 biological process predictions

Show only novel predictionsHighlight processes of functional analogs

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Biological process	GO term ID	Process size	Probability	Func Analog Org
bradykinin biosynthetic process	GO:0002936	1	0.998	Mouse
tissue kallikrein kinin cascade	GO:0002255	1	0.998	Mouse
kinin cascade	GO:0002254	2	0.996	Mouse
left ventricular cardiac muscle tissue morphogenesis	GO:0003220	2	0.995	Mouse
positive regulation of vasoconstriction	GO:0045907	4	0.978	Rat
protein activation cascade	GO:0072376	19	0.977	Mouse
positive regulation of lipid kinase activity	GO:0090218	11	0.970	Mouse
negative regulation of neuron projection regeneration	GO:0070571	3	0.962	Mouse
regulation of phosphatidylinositol 3 kinase activity	GO:0043551	14	0.944	Mouse
positive regulation of lipid metabolic process	GO:0045834	40	0.919	Mouse
binding of sperm to zona pellucida	GO:0007339	34	0.915	Mouse
regulation of blood volume by renin angiotensin	GO:0002016	7	0.854	Mouse
positive regulation of phosphatidylinositol 3 kinase activity	GO:0043552	11	0.819	Mouse
zymogen activation	GO:0031638	41	0.778	Mouse
regulation of lipid kinase activity	GO:0043550	14	0.763	Mouse
cell cell recognition	GO:0009988	44	0.730	Mouse
cellular lipid metabolic process	GO:0044255	323	0.688	Mouse
sperm egg recognition	GO:0035036	37	0.679	Mouse
keratinocyte proliferation	GO:0043616	21	0.669	Mouse
neurological system process involved in regulation of systemic arterial blood pressure	GO:0001976	18	0.647	Mouse
brain renin angiotensin system	GO:0002035	5	0.609	Mouse
inflammatory response	GO:0006954	244	0.600	Mouse
action potential	GO:0001508	78	0.585
cardiac muscle contraction	GO:0060048	32	0.573	Mouse
protein processing	GO:0016485	163	0.573	Mouse
muscle system process	GO:0003012	141	0.518	Mouse
peptide metabolic process	GO:0006518	46	0.502	Mouse
regulation of systemic arterial blood pressure by renin angiotensin	GO:0003081	20	0.474	Mouse
protein maturation	GO:0051604	176	0.473	Mouse
fertilization	GO:0009566	127	0.448	Mouse
single fertilization	GO:0007338	82	0.447	Mouse
cognition	GO:0050890	149	0.437	Mouse
cardiac chamber development	GO:0003205	108	0.395	Mouse
striated muscle contraction	GO:0006941	45	0.378	Mouse
regulation of lipid metabolic process	GO:0019216	118	0.377	Mouse
phospholipid metabolic process	GO:0006644	87	0.354	Mouse
regulation of systemic arterial blood pressure by hormone	GO:0001990	25	0.350	Mouse
regulation of transferase activity	GO:0051338	263	0.332	Mouse
regulation of blood pressure	GO:0008217	93	0.331	Mouse
muscle tissue morphogenesis	GO:0060415	53	0.318	Mouse
regulation of neuron projection regeneration	GO:0070570	7	0.317	Mouse
cellular amide metabolic process	GO:0043603	58	0.308	Mouse
endocrine process	GO:0050886	39	0.293	Mouse
regulation of myelination	GO:0031641	20	0.288	Mouse
axon ensheathment	GO:0008366	76	0.283	Mouse
regulation of neuron differentiation	GO:0045664	281	0.280	Mouse
neuronal action potential	GO:0019228	54	0.261
heart morphogenesis	GO:0003007	178	0.260	Mouse
learning or memory	GO:0007611	148	0.254	Mouse
extracellular structure organization	GO:0043062	148	0.253	Mouse
positive regulation of transferase activity	GO:0051347	167	0.251	Mouse
regulation of membrane potential	GO:0042391	192	0.249
cardiac left ventricle morphogenesis	GO:0003214	9	0.234	Mouse
regulation of blood circulation	GO:1903522	93	0.231	Rat
multicellular organismal signaling	GO:0035637	91	0.207
regulation of response to wounding	GO:1903034	189	0.200	Mouse
cardiac ventricle morphogenesis	GO:0003208	50	0.198	Mouse
cardiac muscle tissue development	GO:0048738	130	0.198	Mouse
cardiac ventricle development	GO:0003231	83	0.196	Mouse
negative regulation of nervous system development	GO:0051961	156	0.195	Mouse
regulation of neuron projection development	GO:0010975	169	0.193	Mouse
cardiac chamber morphogenesis	GO:0003206	93	0.193	Mouse
small gtpase mediated signal transduction	GO:0007264	97	0.192	Mouse
cardiac muscle tissue morphogenesis	GO:0055008	44	0.185	Mouse
regulation of systemic arterial blood pressure	GO:0003073	61	0.185	Mouse
acute inflammatory response	GO:0002526	41	0.183	Mouse
muscle tissue development	GO:0060537	308	0.181	Mouse
macromolecule catabolic process	GO:0009057	281	0.177	Mouse
regulation of tube size	GO:0035150	57	0.173	Mouse Rat
positive regulation of kinase activity	GO:0033674	155	0.171	Mouse
blood circulation	GO:0008015	195	0.165	Mouse Rat
oxidation reduction process	GO:0055114	342	0.164
regulation of cellular response to stress	GO:0080135	159	0.164	Mouse
muscle contraction	GO:0006936	101	0.159	Mouse
synapse organization	GO:0050808	125	0.155	Mouse
vasoconstriction	GO:0042310	27	0.151	Rat
positive regulation of blood circulation	GO:1903524	22	0.149	Rat
organonitrogen compound biosynthetic process	GO:1901566	192	0.146	Mouse
vasodilation	GO:0042311	28	0.143	Mouse
ensheathment of neurons	GO:0007272	76	0.138	Mouse
cellular response to insulin stimulus	GO:0032869	78	0.136
myelination	GO:0042552	74	0.127	Mouse
regulation of cell projection organization	GO:0031344	206	0.121	Mouse
regulation of neurological system process	GO:0031644	22	0.121	Mouse
peptide biosynthetic process	GO:0043043	11	0.121	Mouse
negative regulation of cell development	GO:0010721	169	0.121	Mouse
circulatory system process	GO:0003013	197	0.120	Mouse Rat
neuron projection regeneration	GO:0031102	14	0.117	Mouse
cell recognition	GO:0008037	83	0.117	Mouse
heart contraction	GO:0060047	93	0.116	Mouse
protein catabolic process	GO:0030163	221	0.114	Mouse
transmission of nerve impulse	GO:0019226	76	0.114
extracellular matrix organization	GO:0030198	147	0.109	Mouse
regulation of vasoconstriction	GO:0019229	14	0.109	Rat
axon regeneration	GO:0031103	12	0.105	Mouse
epithelial cell proliferation	GO:0050673	174	0.102	Mouse
negative regulation of neurological system process	GO:0031645	7	0.100	Mouse
negative regulation of neuron differentiation	GO:0045665	101	0.093	Mouse
negative regulation of response to wounding	GO:1903035	77	0.089	Mouse
regulation of blood vessel size	GO:0050880	56	0.088	Mouse Rat
negative regulation of cellular component organization	GO:0051129	194	0.082	Mouse
heart process	GO:0003015	94	0.080	Mouse
regulation of kinase activity	GO:0043549	249	0.079	Mouse
negative regulation of neuron projection development	GO:0010977	50	0.078	Mouse
amine metabolic process	GO:0009308	45	0.075
ventricular cardiac muscle tissue morphogenesis	GO:0055010	32	0.073	Mouse
ventricular cardiac muscle tissue development	GO:0003229	38	0.072	Mouse
vascular process in circulatory system	GO:0003018	62	0.071	Mouse Rat
multicellular organism growth	GO:0035264	161	0.071
regulation of systemic arterial blood pressure mediated by a chemical signal	GO:0003044	33	0.068	Mouse
positive regulation of cellular amine metabolic process	GO:0033240	5	0.068
homeostasis of number of cells	GO:0048872	210	0.066
monosaccharide biosynthetic process	GO:0046364	44	0.065
olfactory learning	GO:0008355	2	0.065
striated muscle tissue development	GO:0014706	293	0.065	Mouse
regulation of anatomical structure size	GO:0090066	178	0.064	Mouse Rat
amelogenesis	GO:0097186	12	0.063	Mouse
cellular amino acid metabolic process	GO:0006520	103	0.060
cellular response to testosterone stimulus	GO:0071394	1	0.060
regulation of cellular ketone metabolic process	GO:0010565	66	0.058
mitochondrion organization	GO:0007005	134	0.058
carbohydrate biosynthetic process	GO:0016051	74	0.057
cellular response to peptide hormone stimulus	GO:0071375	92	0.056
spermatogenesis	GO:0007283	284	0.055
gluconeogenesis	GO:0006094	39	0.054
regulation of myeloid cell differentiation	GO:0045637	96	0.054
cellular ketone metabolic process	GO:0042180	84	0.053
positive regulation of cellular amino acid metabolic process	GO:0045764	3	0.052
regulation of gluconeogenesis	GO:0006111	30	0.052
cellular response to food	GO:0071240	1	0.048
lipid biosynthetic process	GO:0008610	179	0.048
myeloid cell differentiation	GO:0030099	233	0.045
carbohydrate metabolic process	GO:0005975	230	0.045
negative regulation of myelination	GO:0031642	6	0.044	Mouse
amide biosynthetic process	GO:0043604	16	0.044	Mouse
regulation of cellular amino acid metabolic process	GO:0006521	5	0.044
cellular carbohydrate metabolic process	GO:0044262	119	0.044
regulation of cellular amine metabolic process	GO:0033238	20	0.042
negative regulation of cell proliferation	GO:0008285	296	0.041
alpha amino acid metabolic process	GO:1901605	59	0.039
positive regulation of programmed cell death	GO:0043068	218	0.038
cellular amine metabolic process	GO:0044106	44	0.038
monocarboxylic acid metabolic process	GO:0032787	191	0.038
response to peptide	GO:1901652	136	0.037
negative regulation of insulin secretion	GO:0046676	14	0.036
retina development in camera type eye	GO:0060041	119	0.036
reactive oxygen species metabolic process	GO:0072593	84	0.036
generation of precursor metabolites and energy	GO:0006091	103	0.035
skin development	GO:0043588	220	0.034
hexose biosynthetic process	GO:0019319	39	0.033
tissue homeostasis	GO:0001894	115	0.033
positive regulation of cell death	GO:0010942	224	0.033
nitrogen compound transport	GO:0071705	271	0.033
epidermis development	GO:0008544	187	0.033
negative regulation of molecular function	GO:0044092	258	0.032
glucose homeostasis	GO:0042593	128	0.032
regulation of carbohydrate metabolic process	GO:0006109	75	0.032
carboxylic acid biosynthetic process	GO:0046394	86	0.031
cellular response to hormone stimulus	GO:0032870	150	0.031
cellular response to organonitrogen compound	GO:0071417	145	0.030
regulation of cellular carbohydrate metabolic process	GO:0010675	75	0.030
insulin receptor signaling pathway	GO:0008286	49	0.029
negative regulation of protein metabolic process	GO:0051248	282	0.029
response to peptide hormone	GO:0043434	127	0.028
digestive tract development	GO:0048565	190	0.028
metal ion homeostasis	GO:0055065	189	0.028
response to organonitrogen compound	GO:0010243	246	0.027
regulation of eosinophil migration	GO:2000416	2	0.027
positive regulation of apoptotic process	GO:0043065	217	0.027
cation transport	GO:0006812	399	0.026
organic acid biosynthetic process	GO:0016053	86	0.025
cell maturation	GO:0048469	127	0.025
erythrocyte differentiation	GO:0030218	88	0.025
regulation of glucose metabolic process	GO:0010906	60	0.025
gland development	GO:0048732	330	0.025
regulation of synaptic growth at neuromuscular junction	GO:0008582	4	0.024
lipid localization	GO:0010876	126	0.024
glucose metabolic process	GO:0006006	92	0.024
columnar cuboidal epithelial cell differentiation	GO:0002065	82	0.024
regeneration	GO:0031099	38	0.024	Mouse
male gamete generation	GO:0048232	285	0.024
regulation of hormone levels	GO:0010817	211	0.023
myeloid cell homeostasis	GO:0002262	114	0.023
anatomical structure homeostasis	GO:0060249	145	0.023
single organismal cell cell adhesion	GO:0016337	131	0.023
circadian rhythm	GO:0007623	114	0.023
positive regulation of thymocyte migration	GO:2000412	2	0.023
cofactor metabolic process	GO:0051186	80	0.022
amide transport	GO:0042886	138	0.022
neutrophil mediated killing of gram positive bacterium	GO:0070946	2	0.022
multicellular organismal homeostasis	GO:0048871	164	0.022
peptide transport	GO:0015833	133	0.021
axonogenesis	GO:0007409	274	0.021
hexose metabolic process	GO:0019318	98	0.021
nucleotide metabolic process	GO:0009117	332	0.021
morphogenesis of a branching structure	GO:0001763	203	0.021
response to organic cyclic compound	GO:0014070	198	0.021
isoprenoid metabolic process	GO:0006720	29	0.021
negative regulation of insulin secretion involved in cellular response to glucose stimulus	GO:0061179	4	0.021
cellular response to external stimulus	GO:0071496	88	0.020
macromolecule glycosylation	GO:0043413	55	0.020
organic cyclic compound catabolic process	GO:1901361	295	0.020
regulation of angiotensin levels in blood	GO:0002002	4	0.020
vitamin a metabolic process	GO:0006776	2	0.020
cellular response to monosaccharide stimulus	GO:0071326	47	0.020
positive regulation of protein secretion	GO:0050714	52	0.019
regulation of cytokine production	GO:0001817	266	0.019
negative regulation of cell projection organization	GO:0031345	56	0.019	Mouse
neural tube development	GO:0021915	160	0.019
cellular macromolecule catabolic process	GO:0044265	206	0.019
protein glycosylation	GO:0006486	55	0.019
peptide hormone secretion	GO:0030072	109	0.019
reactive nitrogen species metabolic process	GO:2001057	0	0.019
cellular response to peptide	GO:1901653	92	0.019
cellular ion homeostasis	GO:0006873	165	0.019
reactive oxygen species biosynthetic process	GO:1903409	8	0.019
cell type specific apoptotic process	GO:0097285	268	0.019
cellular response to organic cyclic compound	GO:0071407	87	0.019
catecholamine uptake	GO:0090493	4	0.019
granzyme mediated apoptotic signaling pathway	GO:0008626	1	0.018
sensory perception	GO:0007600	245	0.018
learning	GO:0007612	98	0.018
protein modification by small protein conjugation or removal	GO:0070647	207	0.018
spermatid differentiation	GO:0048515	115	0.018
carboxylic acid catabolic process	GO:0046395	51	0.018
dephosphorylation	GO:0016311	129	0.018
regulation of phospholipase c activity	GO:1900274	3	0.018
cellular chemical homeostasis	GO:0055082	215	0.018
maintenance of location	GO:0051235	89	0.017
peptidyl amino acid modification	GO:0018193	336	0.017
cellular homeostasis	GO:0019725	240	0.017
germ cell development	GO:0007281	185	0.017
negative regulation of peptide hormone secretion	GO:0090278	16	0.017
negative regulation of phosphorylation	GO:0042326	166	0.017
glycosylation	GO:0070085	62	0.017
positive regulation of organelle organization	GO:0010638	128	0.017
digestive system development	GO:0055123	200	0.017
purine containing compound metabolic process	GO:0072521	311	0.017
regulation of hydrolase activity	GO:0051336	246	0.017
positive regulation of phospholipase activity	GO:0010518	3	0.017
response to decreased oxygen levels	GO:0036293	59	0.016
negative regulation of protein modification process	GO:0031400	163	0.016
cellularization	GO:0007349	1	0.016
cellular glucose homeostasis	GO:0001678	52	0.016
development of primary sexual characteristics	GO:0045137	143	0.016
single organism cell adhesion	GO:0098602	156	0.016
defense response to bacterium	GO:0042742	119	0.016
negative regulation of intracellular signal transduction	GO:1902532	167	0.015
endothelial cell differentiation	GO:0045446	41	0.015
response to insulin	GO:0032868	100	0.015
regulation of vitamin metabolic process	GO:0030656	3	0.015
response to nutrient levels	GO:0031667	109	0.015
response to oxygen levels	GO:0070482	62	0.015
cell adhesion	GO:0007155	329	0.015
visual perception	GO:0007601	52	0.015
epithelial cell development	GO:0002064	159	0.015
regulation of secretion by cell	GO:1903530	249	0.015
negative regulation of cellular protein metabolic process	GO:0032269	247	0.015
response to acid chemical	GO:0001101	111	0.015
cellular metal ion homeostasis	GO:0006875	151	0.015
regulation of reactive oxygen species metabolic process	GO:2000377	40	0.015
protein secretion	GO:0009306	111	0.014
regulation of body fluid levels	GO:0050878	162	0.014
response to inorganic substance	GO:0010035	96	0.014
regulation of mapk cascade	GO:0043408	248	0.014
defense response to other organism	GO:0098542	197	0.014
inorganic cation transmembrane transport	GO:0098662	207	0.014
carbohydrate derivative biosynthetic process	GO:1901137	183	0.014
negative regulation of phosphorus metabolic process	GO:0010563	184	0.014
positive regulation of eosinophil migration	GO:2000418	2	0.014
anion transport	GO:0006820	177	0.014
wound healing	GO:0042060	157	0.014
immune effector process	GO:0002252	321	0.014
activation of phospholipase c activity	GO:0007202	2	0.014
leukocyte differentiation	GO:0002521	342	0.013
regulation of lymphocyte differentiation	GO:0045619	107	0.013
regulation of t cell differentiation	GO:0045580	83	0.013
defense response to gram positive bacterium	GO:0050830	50	0.013
monosaccharide metabolic process	GO:0005996	106	0.013
leukocyte proliferation	GO:0070661	172	0.013
odontogenesis	GO:0042476	78	0.013	Mouse
regulation of isoprenoid metabolic process	GO:0019747	1	0.013
purine nucleotide metabolic process	GO:0006163	302	0.013
terpenoid metabolic process	GO:0006721	25	0.013
retinoid metabolic process	GO:0001523	24	0.013
sequestering of calcium ion	GO:0051208	18	0.013
regulation of cellular component biogenesis	GO:0044087	181	0.013
response to oxidative stress	GO:0006979	123	0.013
cation homeostasis	GO:0055080	212	0.013
regulation of system process	GO:0044057	200	0.013	Mouse Rat
heterocycle catabolic process	GO:0046700	280	0.013
organelle fission	GO:0048285	170	0.013
cellular response to carbohydrate stimulus	GO:0071322	50	0.013
negative regulation of leukocyte differentiation	GO:1902106	51	0.013
cation transmembrane transport	GO:0098655	266	0.013
response to monosaccharide	GO:0034284	67	0.012
regulation of epithelial cell proliferation	GO:0050678	141	0.012
cellular divalent inorganic cation homeostasis	GO:0072503	127	0.012
regulation of inward rectifier potassium channel activity	GO:1901979	1	0.012
cellular response to biotic stimulus	GO:0071216	92	0.012
renal system development	GO:0072001	225	0.012
eosinophil migration	GO:0072677	3	0.012
chromatin organization	GO:0006325	206	0.012
response to lipopolysaccharide	GO:0032496	128	0.012
t cell differentiation	GO:0030217	174	0.012
branching morphogenesis of an epithelial tube	GO:0048754	159	0.012
hormone secretion	GO:0046879	128	0.012
leukocyte homeostasis	GO:0001776	79	0.012
placenta development	GO:0001890	140	0.012
organic hydroxy compound metabolic process	GO:1901615	203	0.012
cellular respiration	GO:0045333	38	0.012
epithalamus development	GO:0021538	2	0.012
regulation of carbohydrate biosynthetic process	GO:0043255	40	0.012
positive regulation of thyroid hormone generation	GO:2000611	2	0.012
apoptotic signaling pathway	GO:0097190	306	0.012
blood vessel morphogenesis	GO:0048514	285	0.012
glycoprotein metabolic process	GO:0009100	116	0.012
nucleobase containing small molecule metabolic process	GO:0055086	352	0.012
regulation of sequence specific dna binding transcription factor activity	GO:0051090	106	0.011
lymphocyte mediated immunity	GO:0002449	139	0.011
peptide secretion	GO:0002790	114	0.011
positive regulation of protein modification process	GO:0031401	299	0.011
insulin secretion	GO:0030073	89	0.011
cellular potassium ion transport	GO:0071804	43	0.011
energy reserve metabolic process	GO:0006112	39	0.011
dibenzo p dioxin metabolic process	GO:0018894	1	0.011
negative regulation of immune effector process	GO:0002698	55	0.011
thymocyte migration	GO:0072679	2	0.011
positive regulation of phospholipase c activity	GO:0010863	2	0.011
cellular response to lipid	GO:0071396	145	0.011
positive regulation of keratinocyte proliferation	GO:0010838	4	0.011
retinal blood vessel morphogenesis	GO:0061304	3	0.011
negative regulation of peptide secretion	GO:0002792	16	0.011
purine ribonucleoside metabolic process	GO:0046128	241	0.011
positive regulation of cell development	GO:0010720	237	0.011
rho protein signal transduction	GO:0007266	32	0.011
stem cell proliferation	GO:0072089	117	0.011
drug metabolic process	GO:0017144	4	0.011
cellular modified amino acid metabolic process	GO:0006575	63	0.011
protein modification by small protein conjugation	GO:0032446	187	0.011
monocarboxylic acid biosynthetic process	GO:0072330	61	0.011
divalent metal ion transport	GO:0070838	172	0.011
viral gene expression	GO:0019080	3	0.011
protein acylation	GO:0043543	64	0.011
wnt signaling pathway	GO:0016055	188	0.011
sperm motility	GO:0030317	47	0.011
mast cell proliferation	GO:0070662	4	0.011
calcium mediated signaling	GO:0019722	46	0.010
ribonucleotide metabolic process	GO:0009259	291	0.010
calcium ion homeostasis	GO:0055074	127	0.010
regulation of proteolysis	GO:0030162	164	0.010
regulation of leukocyte differentiation	GO:1902105	159	0.010
energy derivation by oxidation of organic compounds	GO:0015980	77	0.010
activation of mapk activity involved in innate immune response	GO:0035419	2	0.010
regulation of organelle organization	GO:0033043	289	0.010
digestion	GO:0007586	40	0.010

Klk1b8 disease predictions

Disease predictions are made from cross-annotation of human disease genes to the identified functional analogs in mouse and predicted with the mouse functional network.

Disease	DO term ID	Probability
nervous system disease	DOID:863	0.017
disease of anatomical entity	DOID:7	0.017
neurodegenerative disease	DOID:1289	0.017
central nervous system disease	DOID:331	0.017
bone disease	DOID:0080001	0.011
connective tissue disease	DOID:65	0.011
musculoskeletal system disease	DOID:17	0.011

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