IMP: Integrative Multi-species Prediction

Mus musculus

133 known processes

Il1a

interleukin 1 alpha

(Aliases: Il-1a)

Entrez: 16175
Ensembl: ENSMUSG00000027399
UniProtKB: Q3U0Y6
UniProtKB: P01582

Process Predictions
Disease Predictions

Il1a biological process predictions

Show only novel predictionsHighlight processes of functional analogs

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Biological process	GO term ID	Process size	Probability	Func Analog Org
cellular response to lipopolysaccharide	GO:0071222	77	0.879
regulation of inflammatory response	GO:0050727	147	0.827	Mouse
cellular response to biotic stimulus	GO:0071216	92	0.705
positive regulation of reactive oxygen species biosynthetic process	GO:1903428	2	0.666
response to molecule of bacterial origin	GO:0002237	143	0.661	Zebrafish Mouse
monocyte chemotactic protein 1 production	GO:0071605	1	0.655
reactive nitrogen species metabolic process	GO:2001057	0	0.654
myeloid cell differentiation	GO:0030099	233	0.649
inflammatory response	GO:0006954	244	0.589
defense response to bacterium	GO:0042742	119	0.587	Zebrafish
positive regulation of cytokine production	GO:0001819	174	0.578
granulocyte migration	GO:0097530	43	0.566	Mouse
regulation of cell activation	GO:0050865	289	0.564
cellular response to lipid	GO:0071396	145	0.547
cellular response to molecule of bacterial origin	GO:0071219	83	0.546
adiponectin secretion	GO:0070162	2	0.544	Mouse
inflammatory response to wounding	GO:0090594	4	0.514
fat soluble vitamin biosynthetic process	GO:0042362	4	0.496
myeloid leukocyte differentiation	GO:0002573	119	0.488
cell chemotaxis	GO:0060326	81	0.471	Mouse
myeloid leukocyte migration	GO:0097529	57	0.462	Mouse
chemotaxis	GO:0006935	247	0.457	Mouse
regulation of response to wounding	GO:1903034	189	0.446	Mouse
response to arsenic containing substance	GO:0046685	5	0.442	Zebrafish
response to lipopolysaccharide	GO:0032496	128	0.441	Zebrafish Mouse
regulation of acute inflammatory response	GO:0002673	27	0.439	Mouse
single organism cell adhesion	GO:0098602	156	0.439
regulation of defense response	GO:0031347	233	0.436	Mouse
single organismal cell cell adhesion	GO:0016337	131	0.433
leukocyte chemotaxis	GO:0030595	69	0.424	Mouse
positive regulation of angiogenesis	GO:0045766	46	0.416
defense response to other organism	GO:0098542	197	0.403	Zebrafish
t cell proliferation	GO:0042098	120	0.400
response to atp	GO:0033198	8	0.398	Mouse
neutrophil migration	GO:1990266	37	0.398	Mouse
neutrophil chemotaxis	GO:0030593	36	0.397	Mouse
apoptotic signaling pathway	GO:0097190	306	0.385
mapk cascade	GO:0000165	281	0.383	Mouse
vitamin d biosynthetic process	GO:0042368	3	0.382
negative regulation of lipid metabolic process	GO:0045833	30	0.372	Mouse
wound healing involved in inflammatory response	GO:0002246	4	0.367
regulation of cytokine production	GO:0001817	266	0.367
regulation of reactive oxygen species biosynthetic process	GO:1903426	2	0.366
protein catabolic process	GO:0030163	221	0.360
positive regulation of lipid catabolic process	GO:0050996	6	0.359	Mouse
positive regulation of cell motility	GO:2000147	116	0.354
response to organic cyclic compound	GO:0014070	198	0.353	Zebrafish Mouse
regulation of t cell activation	GO:0050863	170	0.345
macromolecule catabolic process	GO:0009057	281	0.341
leukocyte apoptotic process	GO:0071887	71	0.340
positive regulation of programmed cell death	GO:0043068	218	0.331
leukocyte migration	GO:0050900	124	0.330	Mouse
regulation of chemotaxis	GO:0050920	53	0.330
keratinocyte migration	GO:0051546	3	0.326
regulation of lymphocyte activation	GO:0051249	240	0.326
cellular ketone metabolic process	GO:0042180	84	0.321
granulocyte chemotaxis	GO:0071621	39	0.317	Mouse
positive regulation of cell activation	GO:0050867	158	0.317
cytokine production	GO:0001816	319	0.314
positive regulation of defense response	GO:0031349	124	0.312	Mouse
regulation of adiponectin secretion	GO:0070163	2	0.310	Mouse
wound healing	GO:0042060	157	0.300
regulation of cellular catabolic process	GO:0031329	242	0.289
positive regulation of membrane protein ectodomain proteolysis	GO:0051044	3	0.285
extrinsic apoptotic signaling pathway in absence of ligand	GO:0097192	55	0.281
cell surface pattern recognition receptor signaling pathway	GO:0002752	2	0.279
anion transport	GO:0006820	177	0.278	Mouse
negative regulation of cellular protein metabolic process	GO:0032269	247	0.277	Mouse
regulation of lipid catabolic process	GO:0050994	15	0.277	Mouse
activation of immune response	GO:0002253	138	0.277
alcohol metabolic process	GO:0006066	116	0.276
leukocyte homeostasis	GO:0001776	79	0.274
leukocyte differentiation	GO:0002521	342	0.274
positive regulation of cellular catabolic process	GO:0031331	148	0.263
t cell activation	GO:0042110	289	0.261
immune response activating cell surface receptor signaling pathway	GO:0002429	72	0.259
nik nf kappab signaling	GO:0038061	14	0.256	Zebrafish
gland development	GO:0048732	330	0.256
positive regulation of lipid metabolic process	GO:0045834	40	0.256	Mouse
leukocyte proliferation	GO:0070661	172	0.255
negative regulation of map kinase activity	GO:0043407	34	0.253	Mouse
signal transduction in absence of ligand	GO:0038034	55	0.253
regulation of interleukin 8 production	GO:0032677	3	0.252
regulation of monocyte chemotaxis	GO:0090025	3	0.252
positive regulation of immune effector process	GO:0002699	107	0.251
regulation of proteolysis	GO:0030162	164	0.247
detection of fungus	GO:0016046	2	0.242
regulation of mapk cascade	GO:0043408	248	0.238	Mouse
regulation of vascular endothelial growth factor production	GO:0010574	13	0.237
stimulatory c type lectin receptor signaling pathway	GO:0002223	2	0.237
regulation of steroid biosynthetic process	GO:0050810	26	0.237
response to organophosphorus	GO:0046683	22	0.236	Mouse
cytokine metabolic process	GO:0042107	71	0.235	Human Mouse
regulation of leukocyte apoptotic process	GO:2000106	56	0.230
response to organonitrogen compound	GO:0010243	246	0.226	Mouse
positive regulation of monocyte chemotaxis	GO:0090026	2	0.226
defense response to gram positive bacterium	GO:0050830	50	0.223
leukocyte cell cell adhesion	GO:0007159	14	0.220
regulation of cell migration	GO:0030334	219	0.220
innate immune response	GO:0045087	157	0.219
positive regulation of lipid transport	GO:0032370	22	0.219	Mouse
positive regulation of transferase activity	GO:0051347	167	0.218
protein kinase b signaling	GO:0043491	74	0.217
steroid metabolic process	GO:0008202	119	0.213
regulation of reactive oxygen species metabolic process	GO:2000377	40	0.210
rho protein signal transduction	GO:0007266	32	0.209
regulation of lymphocyte proliferation	GO:0050670	117	0.205
positive regulation of cell migration	GO:0030335	109	0.205
regulation of vasculature development	GO:1901342	88	0.205
positive regulation of t cell activation	GO:0050870	101	0.205
regulation of insulin receptor signaling pathway	GO:0046626	21	0.202	Mouse
cytokine secretion	GO:0050663	72	0.201	Human
vitamin metabolic process	GO:0006766	23	0.201
lipid biosynthetic process	GO:0008610	179	0.200
jnk cascade	GO:0007254	72	0.200	Mouse
lymphocyte proliferation	GO:0046651	164	0.198
leukocyte activation involved in immune response	GO:0002366	126	0.197
regulation of transferase activity	GO:0051338	263	0.195	Mouse
acute inflammatory response	GO:0002526	41	0.193	Mouse
positive regulation of chemokine biosynthetic process	GO:0045080	6	0.192	Mouse
amine metabolic process	GO:0009308	45	0.189
adaptive immune response based on somatic recombination of immune receptors built from immunoglobulin superfamily domains	GO:0002460	145	0.189
negative regulation of protein modification process	GO:0031400	163	0.188	Mouse
regulation of t cell proliferation	GO:0042129	92	0.186
positive regulation of kinase activity	GO:0033674	155	0.186
cellular response to cytokine stimulus	GO:0071345	189	0.185	Human
regulation of hydrolase activity	GO:0051336	246	0.185
organic anion transport	GO:0015711	137	0.184	Mouse
carboxylic acid transport	GO:0046942	100	0.183	Mouse
regulation of apoptotic signaling pathway	GO:2001233	197	0.182
small molecule biosynthetic process	GO:0044283	132	0.182
interleukin 2 biosynthetic process	GO:0042094	15	0.181	Human
regulation of secretion	GO:0051046	274	0.180	Human Mouse
positive regulation of neutrophil mediated cytotoxicity	GO:0070960	1	0.179
homeostasis of number of cells	GO:0048872	210	0.179
regulation of innate immune response	GO:0045088	91	0.179
protein maturation	GO:0051604	176	0.177
positive regulation of protein modification process	GO:0031401	299	0.176
positive regulation of protein kinase activity	GO:0045860	144	0.176
negative regulation of extrinsic apoptotic signaling pathway	GO:2001237	45	0.176
positive regulation of protein serine threonine kinase activity	GO:0071902	106	0.174
regulation of cellular ketone metabolic process	GO:0010565	66	0.172
regulation of extrinsic apoptotic signaling pathway	GO:2001236	77	0.172
g protein coupled receptor signaling pathway	GO:0007186	243	0.171
mature dendritic cell differentiation	GO:0097029	3	0.170
positive regulation of cytokine biosynthetic process	GO:0042108	40	0.169	Human Mouse
positive regulation of proteolysis	GO:0045862	85	0.168
blood coagulation	GO:0007596	76	0.168
activation of innate immune response	GO:0002218	56	0.168
positive regulation of neutrophil mediated killing of symbiont cell	GO:0070961	1	0.167
regulation of interleukin 2 production	GO:0032663	28	0.165	Human
reactive oxygen species metabolic process	GO:0072593	84	0.165
neutrophil mediated killing of gram negative bacterium	GO:0070945	4	0.160
organic hydroxy compound metabolic process	GO:1901615	203	0.160
cellular amino acid metabolic process	GO:0006520	103	0.159
regulation of cellular response to stress	GO:0080135	159	0.157	Mouse
regulation of membrane protein ectodomain proteolysis	GO:0051043	3	0.157
negative regulation of protein processing	GO:0010955	79	0.157
negative regulation of insulin receptor signaling pathway	GO:0046627	14	0.156	Mouse
positive regulation of cellular amino acid metabolic process	GO:0045764	3	0.156
positive regulation of interferon gamma production	GO:0032729	39	0.156
negative regulation of secretion	GO:0051048	61	0.156	Mouse
positive regulation of innate immune response	GO:0045089	80	0.155
regulation of interferon gamma production	GO:0032649	57	0.155
cellular homeostasis	GO:0019725	240	0.155
regulation of stress activated mapk cascade	GO:0032872	69	0.154	Mouse
positive regulation of map kinase activity	GO:0043406	84	0.153
vascular endothelial growth factor production	GO:0010573	13	0.152
positive regulation of granulocyte chemotaxis	GO:0071624	12	0.152
cellular response to organic cyclic compound	GO:0071407	87	0.151
steroid biosynthetic process	GO:0006694	47	0.151
extrinsic apoptotic signaling pathway	GO:0097191	126	0.150
lipopolysaccharide mediated signaling pathway	GO:0031663	25	0.150
cellular chemical homeostasis	GO:0055082	215	0.150
regulation of jnk cascade	GO:0046328	62	0.149	Mouse
positive regulation of leukocyte proliferation	GO:0070665	73	0.147
positive regulation of macrophage chemotaxis	GO:0010759	5	0.147
regulation of lipid metabolic process	GO:0019216	118	0.147	Mouse
negative regulation of phosphate metabolic process	GO:0045936	184	0.143	Mouse
regulation of hormone levels	GO:0010817	211	0.142	Mouse
regulation of cytokine biosynthetic process	GO:0042035	59	0.141	Human Mouse
nucleotide catabolic process	GO:0009166	217	0.139
negative regulation of macrophage apoptotic process	GO:2000110	3	0.138
regulation of protein serine threonine kinase activity	GO:0071900	157	0.136	Mouse
regulation of map kinase activity	GO:0043405	120	0.136	Mouse
dendritic cell differentiation	GO:0097028	26	0.136
nitrogen compound transport	GO:0071705	271	0.136	Mouse
positive regulation of neutrophil chemotaxis	GO:0090023	12	0.135
regulation of protein processing	GO:0070613	96	0.135
cellular amine metabolic process	GO:0044106	44	0.135
maintenance of location	GO:0051235	89	0.135
positive regulation of secretion by cell	GO:1903532	114	0.135	Human
positive regulation of protein phosphorylation	GO:0001934	242	0.134
regulation of hemostasis	GO:1900046	28	0.133
positive regulation of lymphocyte proliferation	GO:0050671	70	0.132
alcohol biosynthetic process	GO:0046165	43	0.132
chemokine metabolic process	GO:0050755	10	0.130	Mouse
negative regulation of phosphorus metabolic process	GO:0010563	184	0.128	Mouse
regulation of neutrophil mediated killing of gram negative bacterium	GO:0070951	1	0.128
regulation of muscle tissue development	GO:1901861	97	0.127
positive regulation of natural killer cell chemotaxis	GO:2000503	1	0.126
innate immune response activating cell surface receptor signaling pathway	GO:0002220	4	0.126
cell activation involved in immune response	GO:0002263	126	0.126
positive regulation of acute inflammatory response	GO:0002675	16	0.126	Mouse
purine ribonucleoside triphosphate metabolic process	GO:0009205	220	0.124
regulation of cell motility	GO:2000145	236	0.124
response to purine containing compound	GO:0014074	28	0.124	Mouse
stress activated protein kinase signaling cascade	GO:0031098	81	0.123	Mouse
positive regulation of fatty acid transport	GO:2000193	8	0.122	Mouse
negative regulation of myoblast differentiation	GO:0045662	18	0.121
reactive oxygen species biosynthetic process	GO:1903409	8	0.121
regulation of chemokine production	GO:0032642	30	0.120	Mouse
regulation of leukocyte proliferation	GO:0070663	121	0.120
regulation of neutrophil chemotaxis	GO:0090022	14	0.120
regulation of toll like receptor 2 signaling pathway	GO:0034135	3	0.119
organic acid transport	GO:0015849	101	0.119	Mouse
pattern recognition receptor signaling pathway	GO:0002221	47	0.118
positive regulation of apoptotic process	GO:0043065	217	0.118
regulation of protein catabolic process	GO:0042176	108	0.118
thymocyte migration	GO:0072679	2	0.116
ribonucleotide catabolic process	GO:0009261	208	0.116
adaptive immune response	GO:0002250	155	0.116
aromatic compound catabolic process	GO:0019439	286	0.116
regulation of cell adhesion	GO:0030155	154	0.115
protein localization to nucleus	GO:0034504	121	0.114
sequestering of calcium ion	GO:0051208	18	0.114
cell adhesion	GO:0007155	329	0.113
regulation of neutrophil migration	GO:1902622	14	0.112
immune response regulating cell surface receptor signaling pathway	GO:0002768	80	0.112
regulation of angiogenesis	GO:0045765	81	0.112
fat soluble vitamin metabolic process	GO:0006775	11	0.111
stress activated mapk cascade	GO:0051403	80	0.111	Mouse
regulation of glucose transport	GO:0010827	32	0.110	Mouse
positive regulation of protein secretion	GO:0050714	52	0.110	Human
angiogenesis	GO:0001525	201	0.110
positive regulation of reactive oxygen species metabolic process	GO:2000379	11	0.110
regulation of lymphocyte apoptotic process	GO:0070228	41	0.108
interleukin 8 production	GO:0032637	4	0.108
organonitrogen compound catabolic process	GO:1901565	264	0.108
lipid catabolic process	GO:0016042	69	0.108	Mouse
activation of mapk activity	GO:0000187	59	0.108
protein processing	GO:0016485	163	0.106
protein import	GO:0017038	101	0.106
endocrine process	GO:0050886	39	0.105	Mouse
glycosyl compound catabolic process	GO:1901658	206	0.105
interferon gamma production	GO:0032609	67	0.105
positive regulation of interleukin 8 production	GO:0032757	2	0.105
membrane organization	GO:0061024	245	0.105
positive regulation of cellular amine metabolic process	GO:0033240	5	0.104
positive regulation of chemotaxis	GO:0050921	38	0.102
regulation of establishment of protein localization	GO:0070201	181	0.102	Human
regulation of fatty acid transport	GO:2000191	10	0.101	Mouse
nitric oxide biosynthetic process	GO:0006809	25	0.101
regulation of protein secretion	GO:0050708	82	0.101	Human
positive regulation of homeostatic process	GO:0032846	64	0.101	Mouse
mucopolysaccharide metabolic process	GO:1903510	25	0.101
regulation of kinase activity	GO:0043549	249	0.100	Mouse
positive regulation of lymphocyte activation	GO:0051251	140	0.100
positive regulation of eosinophil migration	GO:2000418	2	0.100
protein secretion	GO:0009306	111	0.099	Human
regulation of ion homeostasis	GO:2000021	64	0.099
positive regulation of cell death	GO:0010942	224	0.098
regulation of thymocyte migration	GO:2000410	2	0.097
macrophage chemotaxis	GO:0048246	14	0.097
tissue remodeling	GO:0048771	102	0.096
negative regulation of hydrolase activity	GO:0051346	71	0.096
lipid localization	GO:0010876	126	0.095	Mouse
immune effector process	GO:0002252	321	0.094
skeletal muscle fiber development	GO:0048741	58	0.094
positive regulation of steroid biosynthetic process	GO:0010893	4	0.094
positive regulation of intracellular transport	GO:0032388	70	0.093
positive regulation of thymocyte migration	GO:2000412	2	0.092
positive regulation of cell development	GO:0010720	237	0.092
cellular metal ion homeostasis	GO:0006875	151	0.092
immune response regulating signaling pathway	GO:0002764	125	0.092
regulation of cellular amine metabolic process	GO:0033238	20	0.092
interleukin 1 beta production	GO:0032611	30	0.092	Mouse
negative regulation of protein metabolic process	GO:0051248	282	0.091	Mouse
positive regulation of hematopoietic stem cell proliferation	GO:1902035	2	0.090
t helper 2 cell cytokine production	GO:0035745	4	0.090
regulation of eosinophil migration	GO:2000416	2	0.089
cytoplasmic transport	GO:0016482	234	0.089
negative regulation of phosphorylation	GO:0042326	166	0.089	Mouse
negative regulation of immune system process	GO:0002683	209	0.088
regulation of hormone secretion	GO:0046883	88	0.088	Mouse
regulation of intracellular transport	GO:0032386	159	0.088
peptide hormone secretion	GO:0030072	109	0.088	Mouse
response to insulin	GO:0032868	100	0.087	Mouse
interleukin 12 secretion	GO:0072610	3	0.087
blood vessel morphogenesis	GO:0048514	285	0.087
positive regulation of ion transport	GO:0043270	65	0.087	Mouse
organic hydroxy compound biosynthetic process	GO:1901617	77	0.087
cellular response to insulin stimulus	GO:0032869	78	0.086	Mouse
positive regulation of protein transport	GO:0051222	93	0.086	Human
regulation of prostaglandin secretion	GO:0032306	5	0.086	Mouse
cellular response to transforming growth factor beta stimulus	GO:0071560	88	0.086
homotypic cell cell adhesion	GO:0034109	28	0.085
multicellular organismal homeostasis	GO:0048871	164	0.085	Mouse
icosanoid transport	GO:0071715	14	0.084	Mouse
regulation of steroid metabolic process	GO:0019218	39	0.084
detection of yeast	GO:0001879	2	0.084
cytosolic calcium ion transport	GO:0060401	48	0.083
b cell chemotaxis	GO:0035754	3	0.083
response to growth factor	GO:0070848	198	0.083
monosaccharide transport	GO:0015749	58	0.082	Mouse
lymphocyte activation involved in immune response	GO:0002285	93	0.081
negative regulation of apoptotic signaling pathway	GO:2001234	104	0.081
response to alcohol	GO:0097305	48	0.081
regulation of t cell differentiation	GO:0045580	83	0.081
cellular response to drug	GO:0035690	15	0.078
positive regulation of intracellular protein transport	GO:0090316	42	0.078
cell type specific apoptotic process	GO:0097285	268	0.078
purine nucleoside triphosphate metabolic process	GO:0009144	226	0.078
positive regulation vascular endothelial growth factor production	GO:0010575	10	0.077
cellular response to peptide	GO:1901653	92	0.077	Mouse
negative regulation of kinase activity	GO:0033673	81	0.077	Mouse
peptidyl amino acid modification	GO:0018193	336	0.077
calcium ion homeostasis	GO:0055074	127	0.076
regulation of organic acid transport	GO:0032890	16	0.076	Mouse
regulation of protein kinase activity	GO:0045859	232	0.076	Mouse
regulation of interleukin 6 production	GO:0032675	55	0.076	Mouse
regulation of interleukin 2 biosynthetic process	GO:0045076	13	0.075	Human
regulation of defense response to bacterium	GO:1900424	3	0.075
peptide secretion	GO:0002790	114	0.075	Mouse
prostaglandin transport	GO:0015732	7	0.075	Mouse
peptidyl tyrosine modification	GO:0018212	145	0.074
t cell apoptotic process	GO:0070231	39	0.074
small gtpase mediated signal transduction	GO:0007264	97	0.074
cd4 positive alpha beta t cell cytokine production	GO:0035743	4	0.074
negative regulation of secretion by cell	GO:1903531	54	0.073	Mouse
response to peptide	GO:1901652	136	0.073	Mouse
regulation of cellular amino acid metabolic process	GO:0006521	5	0.072
purine containing compound catabolic process	GO:0072523	213	0.071
nitric oxide metabolic process	GO:0046209	25	0.071
regulation of nik nf kappab signaling	GO:1901222	10	0.071	Zebrafish
insulin receptor signaling pathway	GO:0008286	49	0.071	Mouse
monocarboxylic acid transport	GO:0015718	44	0.071	Mouse
sequestering of metal ion	GO:0051238	19	0.071
phosphatidylinositol mediated signaling	GO:0048015	41	0.071
organic cyclic compound catabolic process	GO:1901361	295	0.070
heat generation	GO:0031649	13	0.070	Mouse
cellular response to external stimulus	GO:0071496	88	0.070
lymphocyte apoptotic process	GO:0070227	54	0.070
carbohydrate transport	GO:0008643	62	0.069	Mouse
positive regulation of dendritic cell dendrite assembly	GO:2000549	1	0.069
exocytosis	GO:0006887	121	0.069
regulation of membrane potential	GO:0042391	192	0.069
antibacterial peptide biosynthetic process	GO:0002780	2	0.068
regulation of monocyte chemotactic protein 1 production	GO:0071637	1	0.068
regulation of nitric oxide biosynthetic process	GO:0045428	18	0.068
regulation of cd4 positive alpha beta t cell proliferation	GO:2000561	2	0.068
regulation of protein kinase b signaling	GO:0051896	56	0.068
negative regulation of proteolysis	GO:0045861	74	0.068
nucleoside phosphate metabolic process	GO:0006753	338	0.067
regulation of protein localization	GO:0032880	231	0.067	Human
purine nucleoside triphosphate catabolic process	GO:0009146	203	0.067
cellular ion homeostasis	GO:0006873	165	0.067
nuclear transport	GO:0051169	139	0.066
protein localization to organelle	GO:0033365	185	0.066
muscle cell differentiation	GO:0042692	261	0.066
regulation of protein transport	GO:0051223	163	0.066	Human
epithelial cell proliferation	GO:0050673	174	0.066
immune response activating signal transduction	GO:0002757	116	0.066
regulation of secretion by cell	GO:1903530	249	0.066	Human Mouse
negative regulation of cell activation	GO:0050866	111	0.065
myotube differentiation	GO:0014902	105	0.065
negative regulation of cell proliferation	GO:0008285	296	0.065	Human
response to drug	GO:0042493	75	0.065
regulation of system process	GO:0044057	200	0.065	Mouse
negative regulation of cellular response to insulin stimulus	GO:1900077	16	0.064	Mouse
nuclear division	GO:0000280	158	0.064	Human
mononuclear cell migration	GO:0071674	8	0.064
ribonucleoside catabolic process	GO:0042454	206	0.064
positive regulation of lymphocyte mediated immunity	GO:0002708	62	0.063
fat cell differentiation	GO:0045444	160	0.063
positive regulation of hydrolase activity	GO:0051345	148	0.063
intracellular protein transport	GO:0006886	204	0.063
positive regulation of jnk cascade	GO:0046330	46	0.063	Mouse
endocytosis	GO:0006897	168	0.063
protein import into nucleus	GO:0006606	95	0.063
fatty acid transport	GO:0015908	28	0.063	Mouse
lipid transport	GO:0006869	98	0.062	Mouse
negative regulation of hormone secretion	GO:0046888	20	0.062	Mouse
lymphocyte differentiation	GO:0030098	242	0.062
morphogenesis of a branching structure	GO:0001763	203	0.062
regulation of ras protein signal transduction	GO:0046578	114	0.061
negative regulation of transferase activity	GO:0051348	85	0.061	Mouse
positive regulation of behavior	GO:0048520	40	0.060
positive regulation of prostaglandin secretion	GO:0032308	5	0.060	Mouse
negative regulation of toll like receptor 2 signaling pathway	GO:0034136	3	0.060
heterocycle catabolic process	GO:0046700	280	0.060
regulation of lipid biosynthetic process	GO:0046890	54	0.060
ribonucleoside metabolic process	GO:0009119	245	0.060
positive regulation of stress activated mapk cascade	GO:0032874	48	0.060	Mouse
single organism nuclear import	GO:1902593	95	0.059
positive regulation of cytokine secretion	GO:0050715	41	0.059	Human
cellular response to oxidative stress	GO:0034599	76	0.059
regulation of rho protein signal transduction	GO:0035023	71	0.059
regulation of adaptive immune response based on somatic recombination of immune receptors built from immunoglobulin superfamily domains	GO:0002822	87	0.059
regulation of nuclear division	GO:0051783	56	0.058	Human
purine ribonucleoside triphosphate catabolic process	GO:0009207	199	0.058
gtp catabolic process	GO:0006184	143	0.058
purine nucleoside metabolic process	GO:0042278	241	0.058
regulation of cell cycle process	GO:0010564	160	0.058	Human
positive regulation of mapk cascade	GO:0043410	170	0.058	Mouse
carbohydrate derivative catabolic process	GO:1901136	231	0.058
nucleoside phosphate catabolic process	GO:1901292	222	0.057
alpha beta t cell activation	GO:0046631	91	0.057
ribonucleoside triphosphate metabolic process	GO:0009199	220	0.057
regulation of protein localization to nucleus	GO:1900180	60	0.057
acid secretion	GO:0046717	33	0.057	Mouse
negative regulation of endopeptidase activity	GO:0010951	44	0.057
negative regulation of cytokine production	GO:0001818	84	0.057	Mouse
regulation of protein maturation	GO:1903317	96	0.056
negative regulation of intracellular signal transduction	GO:1902532	167	0.056	Mouse
myoblast differentiation	GO:0045445	52	0.056
regulation of vitamin metabolic process	GO:0030656	3	0.056
nucleoside metabolic process	GO:0009116	246	0.056
transmembrane receptor protein tyrosine kinase signaling pathway	GO:0007169	247	0.055	Mouse
connective tissue replacement involved in inflammatory response wound healing	GO:0002248	3	0.055
glucose transport	GO:0015758	56	0.055	Mouse
gtp metabolic process	GO:0046039	144	0.055
nucleoside triphosphate catabolic process	GO:0009143	205	0.055
sequestering of triglyceride	GO:0030730	6	0.054
phosphatidylinositol 3 kinase signaling	GO:0014065	36	0.054
divalent metal ion transport	GO:0070838	172	0.054
regulation of neutrophil mediated killing of bacterium	GO:0070950	1	0.054
positive regulation of t cell receptor signaling pathway	GO:0050862	4	0.054
mammary gland epithelium development	GO:0061180	65	0.054
cellular response to organonitrogen compound	GO:0071417	145	0.054	Mouse
inositol lipid mediated signaling	GO:0048017	41	0.053
hexose transport	GO:0008645	56	0.053	Mouse
eosinophil migration	GO:0072677	3	0.053
cellular response to molecule of fungal origin	GO:0071226	2	0.053
regulation of cytoplasmic transport	GO:1903649	112	0.053
positive regulation of nucleoside metabolic process	GO:0045979	91	0.052
i kappab kinase nf kappab signaling	GO:0007249	85	0.052	Mouse
regulation of granulocyte chemotaxis	GO:0071622	17	0.052
regulation of organelle organization	GO:0033043	289	0.052	Human
nuclear import	GO:0051170	95	0.052
muscle fiber development	GO:0048747	76	0.052
negative regulation of molecular function	GO:0044092	258	0.052	Mouse
regulation of multi organism process	GO:0043900	111	0.052
regulation of lipid transport	GO:0032368	36	0.052	Mouse
myotube cell development	GO:0014904	60	0.051
interleukin 1 secretion	GO:0050701	16	0.051
regulation of icosanoid secretion	GO:0032303	8	0.051	Mouse
ectopic germ cell programmed cell death	GO:0035234	9	0.051
cell substrate adhesion	GO:0031589	130	0.051
aminoglycan metabolic process	GO:0006022	34	0.051
positive regulation of interleukin 6 biosynthetic process	GO:0045410	6	0.051	Mouse
purine nucleoside catabolic process	GO:0006152	205	0.051
positive regulation of neutrophil migration	GO:1902624	12	0.051
positive regulation of protein localization to nucleus	GO:1900182	30	0.050
regulation of intracellular protein transport	GO:0033157	82	0.050
regulation of extrinsic apoptotic signaling pathway in absence of ligand	GO:2001239	26	0.050
second messenger mediated signaling	GO:0019932	73	0.050
regulation of interleukin 1 beta secretion	GO:0050706	15	0.050
morphogenesis of a branching epithelium	GO:0061138	193	0.050
regulation of cellular response to insulin stimulus	GO:1900076	30	0.049	Mouse
regulation of ion transport	GO:0043269	215	0.049	Mouse
regulation of b cell chemotaxis	GO:2000537	2	0.049
extracellular structure organization	GO:0043062	148	0.049
glycoprotein metabolic process	GO:0009100	116	0.049
purine ribonucleoside catabolic process	GO:0046130	205	0.049
inflammatory cell apoptotic process	GO:0006925	11	0.049
leukocyte mediated immunity	GO:0002443	174	0.049
response to oxidative stress	GO:0006979	123	0.048
negative regulation of protein serine threonine kinase activity	GO:0071901	49	0.048	Mouse
cellular nitrogen compound catabolic process	GO:0044270	280	0.048
purine nucleotide metabolic process	GO:0006163	302	0.048
regulation of peptidase activity	GO:0052547	96	0.048
positive regulation of response to wounding	GO:1903036	66	0.048	Mouse
astrocyte cell migration	GO:0043615	3	0.048
cytokine mediated signaling pathway	GO:0019221	115	0.048	Human
negative regulation of mapk cascade	GO:0043409	65	0.048	Mouse
hyaluronan metabolic process	GO:0030212	4	0.048
positive regulation of inflammatory response	GO:0050729	47	0.048	Mouse
peptide transport	GO:0015833	133	0.048	Mouse
regulation of monooxygenase activity	GO:0032768	7	0.047
cell killing	GO:0001906	67	0.047
organophosphate catabolic process	GO:0046434	232	0.047
defense response to virus	GO:0051607	68	0.047
nucleoside catabolic process	GO:0009164	206	0.047
positive regulation of b cell chemotaxis	GO:2000538	2	0.047
response to transforming growth factor beta	GO:0071559	88	0.047
positive regulation of secretion	GO:0051047	130	0.047	Human Mouse
positive regulation of organic acid transport	GO:0032892	11	0.047	Mouse
regulation of cell projection assembly	GO:0060491	38	0.047
icosanoid secretion	GO:0032309	12	0.047	Mouse
striated muscle cell development	GO:0055002	125	0.047
positive regulation of lymphocyte migration	GO:2000403	11	0.046
coagulation	GO:0050817	78	0.046
purine nucleotide catabolic process	GO:0006195	211	0.046
response to inorganic substance	GO:0010035	96	0.046	Human

Il1a disease predictions

Disease predictions are made from cross-annotation of human disease genes to the identified functional analogs in mouse and predicted with the mouse functional network.

Disease	DO term ID	Probability
disease of cellular proliferation	DOID:14566	0.130
cancer	DOID:162	0.097
organ system cancer	DOID:0050686	0.097
gastrointestinal system cancer	DOID:3119	0.079

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