IMP: Integrative Multi-species Prediction

Mus musculus

0 known processes

Il18rap

interleukin 18 receptor accessory protein

Ensembl: ENSMUSG00000026068
Entrez: 16174
UniProtKB: Q9Z2B1
UniProtKB: Q0VBK3
UniProtKB: Q3TTU1

Process Predictions
Disease Predictions

Il18rap biological process predictions

Show only novel predictionsHighlight processes of functional analogs

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Biological process	GO term ID	Process size	Probability	Func Analog Org
positive regulation of defense response	GO:0031349	124	0.948	Mouse
stimulatory c type lectin receptor signaling pathway	GO:0002223	2	0.934
cell surface pattern recognition receptor signaling pathway	GO:0002752	2	0.923
detection of fungus	GO:0016046	2	0.902
natural killer cell activation	GO:0030101	44	0.887	Mouse
detection of yeast	GO:0001879	2	0.865
regulation of leukocyte mediated immunity	GO:0002703	104	0.856
regulation of defense response	GO:0031347	233	0.850	Mouse
leukocyte activation involved in immune response	GO:0002366	126	0.847	Mouse
defense response to bacterium	GO:0042742	119	0.830
defense response to gram positive bacterium	GO:0050830	50	0.811
cellular response to lipopolysaccharide	GO:0071222	77	0.806
cytokine production	GO:0001816	319	0.775	Mouse
response to molecule of bacterial origin	GO:0002237	143	0.772
cell chemotaxis	GO:0060326	81	0.767
defense response to other organism	GO:0098542	197	0.757
cytokine mediated signaling pathway	GO:0019221	115	0.747	Mouse
immune effector process	GO:0002252	321	0.745	Mouse
cellular response to cytokine stimulus	GO:0071345	189	0.745	Mouse
regulation of cytokine production	GO:0001817	266	0.691	Mouse
positive regulation of inflammatory response	GO:0050729	47	0.690	Mouse
leukocyte mediated immunity	GO:0002443	174	0.680
myeloid leukocyte mediated immunity	GO:0002444	42	0.678
alpha beta t cell activation	GO:0046631	91	0.671	Mouse
cell killing	GO:0001906	67	0.666
i kappab kinase nf kappab signaling	GO:0007249	85	0.650	Mouse
cd8 positive alpha beta t cell extravasation	GO:0035697	3	0.640
leukocyte mediated cytotoxicity	GO:0001909	62	0.626
positive regulation of t cell costimulation	GO:2000525	2	0.601
myeloid cell differentiation	GO:0030099	233	0.600
response to lipopolysaccharide	GO:0032496	128	0.594
immune response regulating cell surface receptor signaling pathway	GO:0002768	80	0.581
cytokine secretion	GO:0050663	72	0.579	Mouse
pattern recognition receptor signaling pathway	GO:0002221	47	0.566
cell activation involved in immune response	GO:0002263	126	0.560	Mouse
positive regulation of interferon gamma production	GO:0032729	39	0.557	Mouse
regulation of leukocyte mediated cytotoxicity	GO:0001910	38	0.549
positive regulation of t cell activation	GO:0050870	101	0.547	Mouse
regulation of t cell extravasation	GO:2000407	3	0.544
regulation of natural killer cell mediated immunity	GO:0002715	19	0.532
regulation of interferon gamma production	GO:0032649	57	0.530	Mouse
adaptive immune response	GO:0002250	155	0.530	Mouse
cellular response to molecule of bacterial origin	GO:0071219	83	0.527
myeloid leukocyte migration	GO:0097529	57	0.518
positive regulation of monocyte chemotaxis	GO:0090026	2	0.513
positive regulation of leukocyte mediated cytotoxicity	GO:0001912	31	0.511
regulation of innate immune response	GO:0045088	91	0.511
mature dendritic cell differentiation	GO:0097029	3	0.511
regulation of inflammatory response	GO:0050727	147	0.506	Mouse
positive regulation of leukocyte differentiation	GO:1902107	86	0.486	Mouse
positive regulation of leukocyte mediated immunity	GO:0002705	70	0.484
regulation of cd8 positive alpha beta t cell extravasation	GO:2000449	3	0.479
positive regulation of immune effector process	GO:0002699	107	0.475
cellular response to molecule of fungal origin	GO:0071226	2	0.467
regulation of lymphocyte activation	GO:0051249	240	0.453	Mouse
interferon gamma production	GO:0032609	67	0.448	Mouse
immune response activating signal transduction	GO:0002757	116	0.443
mapk cascade	GO:0000165	281	0.441
neutrophil mediated killing of gram positive bacterium	GO:0070946	2	0.433
natural killer cell mediated cytotoxicity	GO:0042267	29	0.421
regulation of protein transport	GO:0051223	163	0.420	Mouse
interleukin 18 mediated signaling pathway	GO:0035655	2	0.417	Mouse
positive regulation of cytokine production	GO:0001819	174	0.413	Mouse
response to molecule of fungal origin	GO:0002238	4	0.412
eosinophil activation	GO:0043307	1	0.397
positive regulation of immunological synapse formation	GO:2000522	1	0.394
regulation of adaptive immune response based on somatic recombination of immune receptors built from immunoglobulin superfamily domains	GO:0002822	87	0.388	Mouse
positive regulation of innate immune response	GO:0045089	80	0.387
helper t cell chemotaxis	GO:0035704	1	0.387
erk1 and erk2 cascade	GO:0070371	77	0.378
inflammatory response	GO:0006954	244	0.372	Mouse
regulation of cytokine secretion	GO:0050707	61	0.372	Mouse
regulation of secretion	GO:0051046	274	0.372	Mouse
t cell extravasation	GO:0072683	4	0.371
positive regulation of tumor necrosis factor superfamily cytokine production	GO:1903557	31	0.371
negative regulation of extrinsic apoptotic signaling pathway	GO:2001237	45	0.370
lymphocyte mediated immunity	GO:0002449	139	0.369
innate immune response	GO:0045087	157	0.358
positive regulation of lymphocyte activation	GO:0051251	140	0.351	Mouse
extrinsic apoptotic signaling pathway	GO:0097191	126	0.347
g protein coupled receptor signaling pathway	GO:0007186	243	0.342
neutrophil chemotaxis	GO:0030593	36	0.339
t cell activation	GO:0042110	289	0.339	Mouse
regulation of response to wounding	GO:1903034	189	0.338	Mouse
leukocyte differentiation	GO:0002521	342	0.337	Mouse
regulation of regulated secretory pathway	GO:1903305	20	0.334
regulation of monocyte chemotaxis	GO:0090025	3	0.331
regulation of chemokine production	GO:0032642	30	0.331	Mouse
neutrophil migration	GO:1990266	37	0.330
interleukin 12 secretion	GO:0072610	3	0.328
granzyme mediated apoptotic signaling pathway	GO:0008626	1	0.327
cation transport	GO:0006812	399	0.324
activation of innate immune response	GO:0002218	56	0.320
granulocyte chemotaxis	GO:0071621	39	0.319
negative regulation of immune system process	GO:0002683	209	0.318	Mouse
adaptive immune response based on somatic recombination of immune receptors built from immunoglobulin superfamily domains	GO:0002460	145	0.318	Mouse
regulation of cell killing	GO:0031341	40	0.310
regulation of cell activation	GO:0050865	289	0.308	Mouse
neutrophil mediated killing of bacterium	GO:0070944	6	0.299
positive regulation of t cell receptor signaling pathway	GO:0050862	4	0.299
positive regulation of lymphocyte mediated immunity	GO:0002708	62	0.298
positive regulation of response to wounding	GO:1903036	66	0.295	Mouse
regulation of extrinsic apoptotic signaling pathway	GO:2001236	77	0.292
cellular response to biotic stimulus	GO:0071216	92	0.291
apoptotic signaling pathway	GO:0097190	306	0.290
regulation of t cell costimulation	GO:2000523	2	0.289
positive regulation of chemokine production	GO:0032722	22	0.284	Mouse
disruption by host of symbiont cells	GO:0051852	11	0.279
detection of other organism	GO:0098543	8	0.277
eosinophil degranulation	GO:0043308	1	0.277
leukocyte migration	GO:0050900	124	0.275
regulation of protein secretion	GO:0050708	82	0.275	Mouse
leukocyte chemotaxis	GO:0030595	69	0.271
eosinophil activation involved in immune response	GO:0002278	1	0.268
lymphocyte activation involved in immune response	GO:0002285	93	0.258	Mouse
positive regulation of cell killing	GO:0031343	33	0.257
acute inflammatory response	GO:0002526	41	0.257	Mouse
natural killer cell mediated immunity	GO:0002228	29	0.255
myeloid leukocyte activation	GO:0002274	83	0.251	Mouse
dendritic cell differentiation	GO:0097028	26	0.249
immune response activating cell surface receptor signaling pathway	GO:0002429	72	0.247
killing of cells in other organism involved in symbiotic interaction	GO:0051883	13	0.247
positive regulation of t cell extravasation	GO:2000409	2	0.247
regulation of antigen receptor mediated signaling pathway	GO:0050854	29	0.245
killing of cells of other organism	GO:0031640	13	0.245
signal transduction in absence of ligand	GO:0038034	55	0.245
regulation of adaptive immune response	GO:0002819	90	0.234	Mouse
immune response regulating signaling pathway	GO:0002764	125	0.233
wound healing	GO:0042060	157	0.226
interaction with symbiont	GO:0051702	14	0.221
positive regulation of natural killer cell mediated cytotoxicity	GO:0045954	16	0.219
negative regulation of eosinophil degranulation	GO:0043310	1	0.217
tumor necrosis factor superfamily cytokine production	GO:0071706	51	0.217
killing by host of symbiont cells	GO:0051873	11	0.214
eosinophil mediated immunity	GO:0002447	1	0.214
regulation of t helper 1 type immune response	GO:0002825	17	0.214	Mouse
protein secretion	GO:0009306	111	0.208	Mouse
regulation of cytokine biosynthetic process	GO:0042035	59	0.207	Mouse
neutrophil mediated immunity	GO:0002446	19	0.207
regulation of lymphocyte mediated immunity	GO:0002706	84	0.200
positive regulation of monocyte extravasation	GO:2000439	1	0.199
positive regulation of cd8 positive alpha beta t cell extravasation	GO:2000451	2	0.198
regulation of dendritic cell chemotaxis	GO:2000508	1	0.191
divalent inorganic cation homeostasis	GO:0072507	138	0.190
negative regulation of macrophage apoptotic process	GO:2000110	3	0.188
sequestering of metal ion	GO:0051238	19	0.186
epithelial tube morphogenesis	GO:0060562	303	0.184
chemokine production	GO:0032602	34	0.184	Mouse
activation of immune response	GO:0002253	138	0.183
interleukin 2 production	GO:0032623	33	0.182	Mouse
regulation of tumor necrosis factor production	GO:0032680	49	0.181
regulation of eosinophil degranulation	GO:0043309	1	0.180
t cell activation involved in immune response	GO:0002286	43	0.179	Mouse
microglial cell activation involved in immune response	GO:0002282	1	0.176
positive regulation of natural killer cell mediated immunity	GO:0002717	16	0.174
neutrophil mediated cytotoxicity	GO:0070942	8	0.171
action potential	GO:0001508	78	0.171
regulation of protein localization	GO:0032880	231	0.170	Mouse
morphogenesis of a branching epithelium	GO:0061138	193	0.169
amine metabolic process	GO:0009308	45	0.169
endocytosis	GO:0006897	168	0.168
positive regulation of mapk cascade	GO:0043410	170	0.168
chemokine mediated signaling pathway	GO:0070098	17	0.167
cytosolic calcium ion transport	GO:0060401	48	0.163
regulation of cell motility	GO:2000145	236	0.161
defense response to virus	GO:0051607	68	0.161
chemokine secretion	GO:0090195	5	0.160	Mouse
antigen receptor mediated signaling pathway	GO:0050851	64	0.159
t cell mediated immunity	GO:0002456	50	0.158
positive regulation of glycoprotein biosynthetic process involved in immunological synapse formation	GO:2000526	1	0.152
positive regulation of lymphocyte proliferation	GO:0050671	70	0.151
regulation of mapk cascade	GO:0043408	248	0.149
reactive nitrogen species metabolic process	GO:2001057	0	0.149
positive regulation of dendritic cell chemotaxis	GO:2000510	1	0.148
t cell proliferation	GO:0042098	120	0.146
rho protein signal transduction	GO:0007266	32	0.146
regulation of cell migration	GO:0030334	219	0.145
cell type specific apoptotic process	GO:0097285	268	0.145
innate immune response activating cell surface receptor signaling pathway	GO:0002220	4	0.144
extrinsic apoptotic signaling pathway in absence of ligand	GO:0097192	55	0.144
cellular response to interleukin 15	GO:0071350	2	0.143
negative regulation of apoptotic signaling pathway	GO:2001234	104	0.142
reactive oxygen species metabolic process	GO:0072593	84	0.140
phagocytosis	GO:0006909	66	0.136
disruption of cells of other organism involved in symbiotic interaction	GO:0051818	13	0.136
membrane organization	GO:0061024	245	0.135
chemotaxis	GO:0006935	247	0.135
monocyte extravasation	GO:0035696	2	0.134
protein localization to organelle	GO:0033365	185	0.134	Mouse
neutrophil mediated killing of symbiont cell	GO:0070943	8	0.133
positive regulation of secretion	GO:0051047	130	0.132	Mouse
myeloid leukocyte differentiation	GO:0002573	119	0.130
ras protein signal transduction	GO:0007265	77	0.130
immune complex clearance	GO:0002434	2	0.129
leukocyte apoptotic process	GO:0071887	71	0.129
regulation of anatomical structure size	GO:0090066	178	0.128
immune complex clearance by monocytes and macrophages	GO:0002436	2	0.126
regulation of reactive oxygen species biosynthetic process	GO:1903426	2	0.126
positive regulation of adaptive immune response	GO:0002821	61	0.125
cellular response to lipid	GO:0071396	145	0.124
peptidyl amino acid modification	GO:0018193	336	0.123
regulation of t cell activation	GO:0050863	170	0.123	Mouse
regulation of secretion by cell	GO:1903530	249	0.123	Mouse
t helper 17 cell chemotaxis	GO:0035705	1	0.122
regulation of cellular response to stress	GO:0080135	159	0.122
regulation of monocyte extravasation	GO:2000437	2	0.122
production of molecular mediator of immune response	GO:0002440	103	0.119
positive regulation of chemokine secretion	GO:0090197	4	0.117	Mouse
second messenger mediated signaling	GO:0019932	73	0.114
blood vessel morphogenesis	GO:0048514	285	0.114
regulation of immunological synapse formation	GO:2000520	2	0.114
regulation of myeloid leukocyte mediated immunity	GO:0002886	25	0.112
positive regulation of macrophage activation	GO:0043032	10	0.112	Mouse
regulation of phagocytosis	GO:0050764	33	0.110
dendritic cell chemotaxis	GO:0002407	7	0.110
positive regulation of tumor necrosis factor production	GO:0032760	30	0.108
detection of biotic stimulus	GO:0009595	10	0.107
innate immune response activating signal transduction	GO:0002758	50	0.106
positive regulation of t cell differentiation	GO:0045582	52	0.106	Mouse
positive regulation of hematopoietic stem cell migration	GO:2000473	1	0.105
toll like receptor signaling pathway	GO:0002224	38	0.105
positive regulation of protein modification process	GO:0031401	299	0.104
regulation of cellular amine metabolic process	GO:0033238	20	0.104
single organismal cell cell adhesion	GO:0016337	131	0.103
negative regulation of growth	GO:0045926	99	0.102
positive regulation of neutrophil chemotaxis	GO:0090023	12	0.101
regulation of apoptotic signaling pathway	GO:2001233	197	0.100
hematopoietic stem cell migration	GO:0035701	1	0.100
regulation of map kinase activity	GO:0043405	120	0.099
regulation of establishment of protein localization	GO:0070201	181	0.099	Mouse
lymphocyte proliferation	GO:0046651	164	0.099
positive regulation of epithelial cell proliferation	GO:0050679	68	0.099
negative regulation of intracellular signal transduction	GO:1902532	167	0.098	Mouse
negative regulation of extrinsic apoptotic signaling pathway in absence of ligand	GO:2001240	16	0.098
positive regulation of cellular amino acid metabolic process	GO:0045764	3	0.097
regulation of homeostatic process	GO:0032844	182	0.097
negative regulation of signal transduction in absence of ligand	GO:1901099	16	0.097
positive regulation of protein transport	GO:0051222	93	0.096	Mouse
regulation of reactive oxygen species metabolic process	GO:2000377	40	0.096
cell adhesion	GO:0007155	329	0.096
response to interleukin 18	GO:0070673	4	0.096	Mouse
multicellular organismal signaling	GO:0035637	91	0.096
single organism cell adhesion	GO:0098602	156	0.095
response to acid chemical	GO:0001101	111	0.094
regulation of b cell mediated immunity	GO:0002712	37	0.094
cellular response to acid chemical	GO:0071229	68	0.094
cellular divalent inorganic cation homeostasis	GO:0072503	127	0.093
cytokine biosynthetic process	GO:0042089	68	0.093	Mouse
negative regulation of chemokine production	GO:0032682	4	0.092	Mouse
small gtpase mediated signal transduction	GO:0007264	97	0.092
positive regulation of hydrolase activity	GO:0051345	148	0.091
sequestering of calcium ion	GO:0051208	18	0.091
negative regulation of protein metabolic process	GO:0051248	282	0.091	Mouse
t helper 1 type immune response	GO:0042088	25	0.090	Mouse
modification of morphology or physiology of other organism	GO:0035821	18	0.090
regulation of immunoglobulin mediated immune response	GO:0002889	37	0.090
positive regulation of chemotaxis	GO:0050921	38	0.090
ameboidal type cell migration	GO:0001667	128	0.090
leukocyte proliferation	GO:0070661	172	0.089
jnk cascade	GO:0007254	72	0.089
cd4 positive alpha beta t cell differentiation involved in immune response	GO:0002294	28	0.089	Mouse
positive regulation of cytokine secretion	GO:0050715	41	0.088	Mouse
regulation of rho protein signal transduction	GO:0035023	71	0.088
detection of stimulus	GO:0051606	84	0.088
positive regulation of cell activation	GO:0050867	158	0.088	Mouse
cellular extravasation	GO:0045123	17	0.087
regulation of vascular endothelial growth factor production	GO:0010574	13	0.087
macromolecule catabolic process	GO:0009057	281	0.086
positive regulation of neutrophil mediated killing of symbiont cell	GO:0070961	1	0.086
regulation of natural killer cell mediated cytotoxicity	GO:0042269	19	0.086
wnt signaling pathway	GO:0016055	188	0.085
regulation of acute inflammatory response	GO:0002673	27	0.085
positive regulation of secretion by cell	GO:1903532	114	0.084	Mouse
positive regulation of phagocytosis	GO:0050766	26	0.084
negative regulation of leukocyte mediated immunity	GO:0002704	29	0.084
calcium ion homeostasis	GO:0055074	127	0.084
cellular amine metabolic process	GO:0044106	44	0.083
t cell differentiation	GO:0030217	174	0.083	Mouse
regulation of alpha beta t cell activation	GO:0046634	53	0.083
regulation of chemokine secretion	GO:0090196	4	0.082	Mouse
positive regulation of cellular amine metabolic process	GO:0033240	5	0.082
alpha beta t cell differentiation	GO:0046632	69	0.082	Mouse
regulation of membrane potential	GO:0042391	192	0.081
regulation of macrophage activation	GO:0043030	17	0.081	Mouse
nitrogen compound transport	GO:0071705	271	0.080	Mouse
regulation of leukocyte differentiation	GO:1902105	159	0.079	Mouse
regulation of jun kinase activity	GO:0043506	40	0.079
positive regulation of adaptive immune response based on somatic recombination of immune receptors built from immunoglobulin superfamily domains	GO:0002824	61	0.078
positive regulation of myeloid leukocyte mediated immunity	GO:0002888	14	0.077
microglial cell activation	GO:0001774	3	0.077
cellular calcium ion homeostasis	GO:0006874	119	0.077
establishment of protein localization to organelle	GO:0072594	118	0.077	Mouse
positive regulation of intracellular transport	GO:0032388	70	0.076	Mouse
regulation of phospholipase c activity	GO:1900274	3	0.076
regulation of leukocyte proliferation	GO:0070663	121	0.076
positive regulation of behavior	GO:0048520	40	0.075
cell recognition	GO:0008037	83	0.075
regulation of angiogenesis	GO:0045765	81	0.075
regulation of symbiosis encompassing mutualism through parasitism	GO:0043903	52	0.074
negative thymic t cell selection	GO:0045060	12	0.074
leukocyte degranulation	GO:0043299	27	0.073
amino sugar catabolic process	GO:0046348	1	0.073
regulation of vesicle mediated transport	GO:0060627	139	0.072
leukocyte homeostasis	GO:0001776	79	0.072
skeletal muscle organ development	GO:0060538	163	0.072
regulation of extrinsic apoptotic signaling pathway in absence of ligand	GO:2001239	26	0.071
positive regulation of cytokine biosynthetic process	GO:0042108	40	0.071
regulation of stress activated mapk cascade	GO:0032872	69	0.071
protein import into nucleus	GO:0006606	95	0.071	Mouse
regulation of acute inflammatory response to non antigenic stimulus	GO:0002877	2	0.070
anion transport	GO:0006820	177	0.070
negative regulation of interferon gamma production	GO:0032689	18	0.070	Mouse
t helper 2 cell cytokine production	GO:0035745	4	0.070
homeostasis of number of cells	GO:0048872	210	0.069
urogenital system development	GO:0001655	261	0.069
positive regulation of apoptotic process	GO:0043065	217	0.069
protein catabolic process	GO:0030163	221	0.069
receptor mediated endocytosis	GO:0006898	51	0.068
regulation of granulocyte chemotaxis	GO:0071622	17	0.068
detection of external biotic stimulus	GO:0098581	9	0.068
positive regulation of antigen receptor mediated signaling pathway	GO:0050857	9	0.067
t helper cell differentiation	GO:0042093	28	0.067	Mouse
regulation of hydrolase activity	GO:0051336	246	0.066
regulation of blood pressure	GO:0008217	93	0.066
antibacterial peptide secretion	GO:0002779	1	0.066
cellular amino acid metabolic process	GO:0006520	103	0.066
type 2 immune response	GO:0042092	23	0.066
positive regulation of immune complex clearance by monocytes and macrophages	GO:0090265	2	0.065
t cell differentiation involved in immune response	GO:0002292	30	0.065	Mouse
alpha beta t cell differentiation involved in immune response	GO:0002293	30	0.064	Mouse
nucleotide metabolic process	GO:0009117	332	0.064
regulation of myeloid cell differentiation	GO:0045637	96	0.064
negative regulation of cell activation	GO:0050866	111	0.064
regulation of exocytosis	GO:0017157	61	0.064
glial cell differentiation	GO:0010001	131	0.064
bone resorption	GO:0045453	38	0.063
cd4 positive alpha beta t cell differentiation	GO:0043367	41	0.063	Mouse
positive regulation of protein phosphorylation	GO:0001934	242	0.063
positive regulation of alpha beta t cell activation	GO:0046635	39	0.063
antibacterial peptide production	GO:0002778	2	0.062
protein localization to nucleus	GO:0034504	121	0.061	Mouse
regulation of cell projection assembly	GO:0060491	38	0.061
regulation of angiotensin levels in blood	GO:0002002	4	0.059
regulation of hematopoietic stem cell migration	GO:2000471	1	0.059
response to organonitrogen compound	GO:0010243	246	0.059
cd4 positive alpha beta t cell cytokine production	GO:0035743	4	0.058
transmission of nerve impulse	GO:0019226	76	0.058
negative regulation of chemokine biosynthetic process	GO:0045079	2	0.058	Mouse
carbohydrate derivative biosynthetic process	GO:1901137	183	0.058
regulation of ras protein signal transduction	GO:0046578	114	0.058
regulation of ion homeostasis	GO:2000021	64	0.058
regulation of neutrophil mediated killing of bacterium	GO:0070950	1	0.058
extracellular matrix organization	GO:0030198	147	0.057
toll like receptor 7 signaling pathway	GO:0034154	4	0.057
myeloid cell apoptotic process	GO:0033028	22	0.057
peptidyl tyrosine modification	GO:0018212	145	0.057
macrophage chemotaxis	GO:0048246	14	0.057
cellular ketone metabolic process	GO:0042180	84	0.057
epithelial cell proliferation	GO:0050673	174	0.056
circulatory system process	GO:0003013	197	0.056
divalent inorganic cation transport	GO:0072511	178	0.056
activation of mapk activity	GO:0000187	59	0.055
t cell costimulation	GO:0031295	14	0.055
regulation of immune complex clearance by monocytes and macrophages	GO:0090264	2	0.055
positive regulation of reactive oxygen species metabolic process	GO:2000379	11	0.055
regulation of type 2 immune response	GO:0002828	18	0.055
protein import	GO:0017038	101	0.055	Mouse
regulation of neutrophil chemotaxis	GO:0090022	14	0.055
synaptic transmission	GO:0007268	329	0.054
reactive oxygen species biosynthetic process	GO:1903409	8	0.054
cd4 positive alpha beta t cell activation	GO:0035710	45	0.054	Mouse
positive regulation of protein secretion	GO:0050714	52	0.054	Mouse
positive regulation of granulocyte chemotaxis	GO:0071624	12	0.053
bone morphogenesis	GO:0060349	78	0.053
regulation of cellular ketone metabolic process	GO:0010565	66	0.052
negative regulation of phosphate metabolic process	GO:0045936	184	0.052
regulation of mast cell activation	GO:0033003	21	0.052
purine containing compound metabolic process	GO:0072521	311	0.051
cytosolic calcium ion homeostasis	GO:0051480	70	0.051
positive regulation of reactive oxygen species biosynthetic process	GO:1903428	2	0.050
muscle contraction	GO:0006936	101	0.050
cytoplasmic transport	GO:0016482	234	0.050	Mouse
regulation of immunoglobulin production	GO:0002637	42	0.049
sensory perception	GO:0007600	245	0.049
regulation of erk1 and erk2 cascade	GO:0070372	71	0.049
intracellular protein transport	GO:0006886	204	0.049	Mouse
stress activated protein kinase signaling cascade	GO:0031098	81	0.048
regulation of inflammatory response to antigenic stimulus	GO:0002861	21	0.048
b cell activation	GO:0042113	161	0.048
regulation of epithelial cell proliferation	GO:0050678	141	0.048
release of sequestered calcium ion into cytosol	GO:0051209	42	0.047
regulation of toll like receptor 4 signaling pathway	GO:0034143	4	0.047
interleukin 1 secretion	GO:0050701	16	0.047
regulation of chemokine biosynthetic process	GO:0045073	8	0.047	Mouse
myeloid cell activation involved in immune response	GO:0002275	34	0.047
regulation of t cell differentiation	GO:0045580	83	0.046	Mouse
renal system development	GO:0072001	225	0.046
eosinophil migration	GO:0072677	3	0.046
positive regulation of interleukin 6 production	GO:0032755	37	0.046	Mouse
gliogenesis	GO:0042063	141	0.045
mast cell activation	GO:0045576	27	0.045
regulation of hematopoietic stem cell proliferation	GO:1902033	3	0.045
antibacterial peptide biosynthetic process	GO:0002780	2	0.045
exocytosis	GO:0006887	121	0.045
positive regulation of interleukin 12 production	GO:0032735	21	0.045
vascular endothelial growth factor production	GO:0010573	13	0.045
regulation of leukocyte apoptotic process	GO:2000106	56	0.045
alpha beta t cell proliferation	GO:0046633	21	0.045
regulation of cellular amino acid metabolic process	GO:0006521	5	0.044
regulation of endocytosis	GO:0030100	69	0.044
regulation of eosinophil migration	GO:2000416	2	0.044
b cell activation involved in immune response	GO:0002312	50	0.044
regulation of transferase activity	GO:0051338	263	0.044
regulation of protein serine threonine kinase activity	GO:0071900	157	0.044
symbiosis encompassing mutualism through parasitism	GO:0044403	83	0.044
positive regulation of glial cell differentiation	GO:0045687	21	0.044
regulation of multi organism process	GO:0043900	111	0.044
positive regulation of cell migration	GO:0030335	109	0.044
tissue homeostasis	GO:0001894	115	0.043
positive regulation of erk1 and erk2 cascade	GO:0070374	47	0.043
regulation of angiotensin metabolic process	GO:0060177	4	0.043
negative regulation of lipopolysaccharide mediated signaling pathway	GO:0031665	3	0.042
tumor necrosis factor production	GO:0032640	50	0.042
positive regulation of inflammatory response to antigenic stimulus	GO:0002863	11	0.042
regulation of t cell proliferation	GO:0042129	92	0.042
anatomical structure homeostasis	GO:0060249	145	0.042
response to growth factor	GO:0070848	198	0.041
metal ion homeostasis	GO:0055065	189	0.041
neuron migration	GO:0001764	122	0.041
gland development	GO:0048732	330	0.041
positive regulation of alpha beta t cell proliferation	GO:0046641	12	0.040
positive regulation of t helper 1 cell differentiation	GO:0045627	4	0.040
positive regulation of neutrophil mediated cytotoxicity	GO:0070960	1	0.040
regulation of t helper 2 cell cytokine production	GO:2000551	3	0.040
extracellular structure organization	GO:0043062	148	0.040
positive regulation of b cell mediated immunity	GO:0002714	26	0.040
nucleobase containing small molecule metabolic process	GO:0055086	352	0.040
positive regulation of phospholipase c activity	GO:0010863	2	0.039
ossification	GO:0001503	216	0.039
positive regulation of myeloid leukocyte differentiation	GO:0002763	26	0.039
neutrophil mediated killing of gram negative bacterium	GO:0070945	4	0.039
alpha beta t cell activation involved in immune response	GO:0002287	31	0.039	Mouse
microglia development	GO:0014005	2	0.039
regulation of immunoglobulin production in mucosal tissue	GO:2000557	1	0.039
interleukin 12 production	GO:0032615	32	0.039
regulation of lymphocyte differentiation	GO:0045619	107	0.039	Mouse
regulation of cellular component biogenesis	GO:0044087	181	0.038
ribonucleotide metabolic process	GO:0009259	291	0.038
microglia differentiation	GO:0014004	2	0.038
negative regulation of cell proliferation	GO:0008285	296	0.037
regulation of hormone levels	GO:0010817	211	0.037
leukocyte cell cell adhesion	GO:0007159	14	0.037
positive regulation of myotube differentiation	GO:0010831	24	0.037
muscle tissue development	GO:0060537	308	0.037
positive regulation of b cell chemotaxis	GO:2000538	2	0.037
regulation of actin filament based process	GO:0032970	99	0.037
purine ribonucleoside triphosphate catabolic process	GO:0009207	199	0.037
negative regulation of toll like receptor 2 signaling pathway	GO:0034136	3	0.037
peptide secretion	GO:0002790	114	0.037
positive regulation of cell motility	GO:2000147	116	0.037
positive regulation of cell projection organization	GO:0031346	95	0.037
blood circulation	GO:0008015	195	0.036
regulation of interleukin 8 production	GO:0032677	3	0.036
regulation of t cell receptor signaling pathway	GO:0050856	21	0.036
positive regulation of cell development	GO:0010720	237	0.036
negative regulation of defense response	GO:0031348	77	0.036
negative regulation of serotonin secretion	GO:0014063	2	0.036
negative regulation of myeloid leukocyte differentiation	GO:0002762	20	0.036
divalent metal ion transport	GO:0070838	172	0.035
positive regulation of t helper 2 cell cytokine production	GO:2000553	3	0.035
tumor necrosis factor biosynthetic process	GO:0042533	10	0.035
positive regulation of transferase activity	GO:0051347	167	0.035
cellularization	GO:0007349	1	0.035
positive regulation of cell death	GO:0010942	224	0.035
branching morphogenesis of an epithelial tube	GO:0048754	159	0.035
positive regulation of camp mediated signaling	GO:0043950	3	0.034
t cell migration	GO:0072678	19	0.034
regulation of interleukin 2 production	GO:0032663	28	0.034
positive regulation of dendritic cell dendrite assembly	GO:2000549	1	0.034
macrophage activation	GO:0042116	27	0.034	Mouse
regulation of ossification	GO:0030278	112	0.034
telencephalon cell migration	GO:0022029	55	0.034
regulation of actin cytoskeleton organization	GO:0032956	84	0.034
transcription factor import into nucleus	GO:0042991	26	0.034	Mouse
regulation of endothelial cell proliferation	GO:0001936	23	0.034
macrophage differentiation	GO:0030225	20	0.034
negative regulation of lymphocyte activation	GO:0051250	91	0.034
response to sterol	GO:0036314	4	0.033
positive regulation of protein kinase activity	GO:0045860	144	0.033
regulation of interleukin 6 production	GO:0032675	55	0.033	Mouse
positive regulation of natural killer cell chemotaxis	GO:2000503	1	0.033
regulated secretory pathway	GO:0045055	32	0.033
positive regulation of thymocyte migration	GO:2000412	2	0.033
regulation of cellular catabolic process	GO:0031329	242	0.033
regulation of tumor necrosis factor superfamily cytokine production	GO:1903555	50	0.033
lymphocyte migration	GO:0072676	26	0.033

Il18rap disease predictions

Disease predictions are made from cross-annotation of human disease genes to the identified functional analogs in mouse and predicted with the mouse functional network.

Disease	DO term ID	Probability
cancer	DOID:162	0.053
disease of cellular proliferation	DOID:14566	0.053
organ system cancer	DOID:0050686	0.036

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