Mus musculus

129 known processes

Irs1

insulin receptor substrate 1

(Aliases: IRS-1,G972R)

Irs1 biological process predictions


Filter by process size:
Biological processGO term IDProcess sizeProbabilityFunc Analog Org
positive regulation of lipid kinase activityGO:0090218110.972
regulation of cellular ketone metabolic processGO:0010565660.971
Human
positive regulation of kinase activityGO:00336741550.958
transmembrane receptor protein tyrosine kinase signaling pathwayGO:00071692470.951
Human Mouse Rat Fly
cellular ketone metabolic processGO:0042180840.941
Human
positive regulation of lipid metabolic processGO:0045834400.862
regulation of insulin receptor signaling pathwayGO:0046626210.850
Rat
regulation of transferase activityGO:00513382630.842
regulation of kinase activityGO:00435492490.835
cellular amino acid metabolic processGO:00065201030.831
regulation of protein kinase activityGO:00458592320.824
regulation of protein serine threonine kinase activityGO:00719001570.819
striated muscle tissue developmentGO:00147062930.799
cell adhesionGO:00071553290.796
axonogenesisGO:00074092740.796
positive regulation of protein serine threonine kinase activityGO:00719021060.771
small gtpase mediated signal transductionGO:0007264970.762
positive regulation of cellular amine metabolic processGO:003324050.762
heart morphogenesisGO:00030071780.757
regulation of cell adhesionGO:00301551540.728
regulation of cellular response to stressGO:00801351590.721
regulation of mapk cascadeGO:00434082480.707
muscle cell differentiationGO:00426922610.701
negative regulation of cell proliferationGO:00082852960.691
positive regulation of protein kinase activityGO:00458601440.689
cytoplasmic transportGO:00164822340.686
cellular response to insulin stimulusGO:0032869780.667
mapk cascadeGO:00001652810.662
positive regulation of mapk cascadeGO:00434101700.642
cell cell adhesion via plasma membrane adhesion moleculesGO:0098742400.632
regulation of protein localizationGO:00328802310.627
female gamete generationGO:0007292740.619
Fly
regulation of cellular catabolic processGO:00313292420.618
Human
cellular response to organonitrogen compoundGO:00714171450.617
syncytium formation by plasma membrane fusionGO:0000768420.606
positive regulation of protein modification processGO:00314012990.603
regulation of cellular amino acid metabolic processGO:000652150.598
regulation of cytoskeleton organizationGO:00514931220.591
glucose metabolic processGO:0006006920.589
Human
response to monosaccharideGO:0034284670.582
Mouse
negative regulation of synapse assemblyGO:005196430.574
axon guidanceGO:00074111410.569
stem cell proliferationGO:00720891170.558
regulation of secretion by cellGO:19035302490.547
Human Mouse Rat
ras protein signal transductionGO:0007265770.529
response to organonitrogen compoundGO:00102432460.526
positive regulation of protein phosphorylationGO:00019342420.526
actin cytoskeleton organizationGO:00300362200.525
response to testosteroneGO:003357430.521
protein localization to organelleGO:00333651850.513
polysaccharide metabolic processGO:0005976390.506
Human
positive regulation of transferase activityGO:00513471670.505
olfactory learningGO:000835520.503
Fly
establishment of protein localization to organelleGO:00725941180.500
regulation of lipid kinase activityGO:0043550140.493
regulation of phosphatidylinositol 3 kinase activityGO:0043551140.492
skeletal muscle organ developmentGO:00605381630.491
negative regulation of cellular protein metabolic processGO:00322692470.488
monosaccharide metabolic processGO:00059961060.487
Human
regulation of actin cytoskeleton organizationGO:0032956840.483
response to growth factorGO:00708481980.482
positive regulation of cell developmentGO:00107202370.480
regulation of neuron differentiationGO:00456642810.478
regulation of cellular component biogenesisGO:00440871810.478
myeloid cell differentiationGO:00300992330.476
positive regulation of map kinase activityGO:0043406840.475
regionalizationGO:00030023370.469
regulation of proteolysisGO:00301621640.464
regulation of protein transportGO:00512231630.464
regulation of cell migrationGO:00303342190.464
multicellular organism growthGO:00352641610.462
Fly
cognitionGO:00508901490.462
Fly
regulation of lipid metabolic processGO:00192161180.461
positive regulation of cellular amino acid metabolic processGO:004576430.460
positive regulation of nervous system developmentGO:00519622210.459
positive regulation of cell motilityGO:20001471160.451
negative regulation of kinase activityGO:0033673810.450
Mouse
single organism nuclear importGO:1902593950.445
positive regulation of cell migrationGO:00303351090.442
organ growthGO:00352651170.440
Fly
protein processingGO:00164851630.435
glycerolipid biosynthetic processGO:0045017500.435
regulation of stress activated mapk cascadeGO:0032872690.429
digestive tract morphogenesisGO:00485461470.424
cellular response to peptideGO:1901653920.421
axial mesoderm morphogenesisGO:004831950.421
neural precursor cell proliferationGO:00613511210.420
sensory organ morphogenesisGO:00905962420.417
regulation of map kinase activityGO:00434051200.409
polarity specification of proximal distal axisGO:001008520.403
digestive tract developmentGO:00485651900.401
regulation of cellular amine metabolic processGO:0033238200.398
glucose transportGO:0015758560.393
Human
positive regulation of phosphatidylinositol 3 kinase activityGO:0043552110.390
positive regulation of growthGO:00459271040.387
Fly
muscle system processGO:00030121410.383
response to peptide hormoneGO:00434341270.383
regulation of cell morphogenesis involved in differentiationGO:00107691510.381
neuron projection guidanceGO:00974851410.379
development of primary sexual characteristicsGO:00451371430.378
response to amino acidGO:0043200370.376
syncytium formationGO:0006949430.376
carbohydrate metabolic processGO:00059752300.376
Human
positive regulation of cellular component biogenesisGO:0044089940.370
regulation of anatomical structure sizeGO:00900661780.364
Fly
germ cell developmentGO:00072811850.359
Fly
cellular lipid metabolic processGO:00442553230.357
muscle tissue developmentGO:00605373080.354
embryonic placenta developmentGO:0001892980.354
cell growthGO:00160491300.353
Fly
ribonucleotide metabolic processGO:00092592910.350
positive regulation of neuron differentiationGO:00456661410.349
macromolecule catabolic processGO:00090572810.348
actin filament organizationGO:00070151130.347
protein localization to nucleusGO:00345041210.345
regulation of cell motilityGO:20001452360.343
regulation of protein import into nucleusGO:0042306520.338
digestive system developmentGO:00551232000.336
regulation of actin filament based processGO:0032970990.334
telencephalon developmentGO:00215371860.332
amine metabolic processGO:0009308450.329
cell type specific apoptotic processGO:00972852680.322
Mouse
germ line stem cell divisionGO:004207820.322
Fly
negative regulation of molecular functionGO:00440922580.318
Mouse
glucose importGO:0046323320.317
Human
connective tissue developmentGO:00614481790.316
apoptotic signaling pathwayGO:00971903060.314
protein import into nucleusGO:0006606950.314
protein importGO:00170381010.314
learning or memoryGO:00076111480.305
Fly
nuclear importGO:0051170950.303
camera type eye developmentGO:00430102660.297
hindbrain developmentGO:00309021280.295
regulation of intracellular protein transportGO:0033157820.295
morphogenesis of embryonic epitheliumGO:00163311590.290
appendage developmentGO:00487361660.289
skeletal muscle satellite cell maintenance involved in skeletal muscle regenerationGO:001483430.288
spermatogenesisGO:00072832840.287
Fly
peptidyl serine modificationGO:0018209830.287
peptide secretionGO:00027901140.279
Human Mouse Rat
single organism cell adhesionGO:00986021560.279
wnt signaling pathwayGO:00160551880.278
regulation of cell projection assemblyGO:0060491380.276
regulation of hormone secretionGO:0046883880.276
Human Mouse Rat
glucan metabolic processGO:0044042320.274
Human
intracellular protein transportGO:00068862040.273
positive regulation of glial cell proliferationGO:006025240.269
negative regulation of apoptotic signaling pathwayGO:20012341040.265
regulation of endopeptidase activityGO:0052548890.265
establishment or maintenance of cell polarityGO:0007163860.265
regulation of cellular component sizeGO:00325351210.264
positive regulation of glycogen metabolic processGO:007087580.258
Human
positive regulation of lymphocyte activationGO:00512511400.257
Mouse
skeletal system developmentGO:00015013560.254
protein targetingGO:00066051430.253
microtubule based processGO:00070172360.253
regulation of fatty acid metabolic processGO:0019217280.252
Human
single organismal cell cell adhesionGO:00163371310.249
stem cell differentiationGO:00488632680.247
regulation of stem cell proliferationGO:0072091780.246
maintenance of cell numberGO:009872730.246
regulation of system processGO:00440572000.245
regulation of cell projection organizationGO:00313442060.245
positive regulation of neuron projection developmentGO:0010976790.244
peptide transportGO:00158331330.244
Human Mouse Rat
axial mesoderm formationGO:004832030.242
peptidyl serine phosphorylationGO:0018105740.240
glial cell differentiationGO:00100011310.240
regulation of establishment of protein localizationGO:00702011810.238
regulation of organelle organizationGO:00330432890.237
neural tube formationGO:00018411080.237
circulatory system processGO:00030131970.236
cell fate commitmentGO:00451652100.234
positive regulation of cytoskeleton organizationGO:0051495490.233
associative learningGO:0008306610.233
Fly
regulation of mitotic cell cycleGO:00073461260.232
regulation of intracellular transportGO:00323861590.230
negative regulation of protein processingGO:0010955790.228
cellular response to peptide hormone stimulusGO:0071375920.227
neuron apoptotic processGO:00514021420.226
negative regulation of neuron projection developmentGO:0010977500.225
stem cell developmentGO:00488642190.225
myotube differentiationGO:00149021050.224
positive regulation of programmed cell deathGO:00430682180.223
peptidyl amino acid modificationGO:00181933360.221
carbohydrate transportGO:0008643620.221
Human
muscle fiber developmentGO:0048747760.218
regulation of body fluid levelsGO:00508781620.217
membrane organizationGO:00610242450.216
positive regulation of lipid catabolic processGO:005099660.216
Human
regulation of neuron projection developmentGO:00109751690.215
generation of precursor metabolites and energyGO:00060911030.215
Human
cell cell adhesionGO:0098609410.213
urogenital system developmentGO:00016552610.212
synapse organizationGO:00508081250.212
negative regulation of phosphorylationGO:00423261660.212
Mouse
energy reserve metabolic processGO:0006112390.212
Human
insulin receptor signaling pathwayGO:0008286490.211
Human Mouse Rat Fly
kidney developmentGO:00018222130.210
regulation of peptide secretionGO:0002791770.210
Human Mouse Rat
positive regulation of organelle organizationGO:00106381280.209
regulation of fatty acid beta oxidationGO:003199810.208
Human
neural tube developmentGO:00219151600.206
cartilage developmentGO:00512161400.204
translationGO:0006412930.202
endothelial cell migrationGO:0043542440.201
extrinsic apoptotic signaling pathwayGO:00971911260.201
regulation of peptidase activityGO:0052547960.200
muscle contractionGO:00069361010.200
monosaccharide transportGO:0015749580.200
Human
transmembrane receptor protein serine threonine kinase signaling pathwayGO:00071781940.199
Fly
ribonucleoside metabolic processGO:00091192450.198
cell divisionGO:00513011200.198
Fly
blood circulationGO:00080151950.198
cellular response to dna damage stimulusGO:00069742070.197
cellular response to growth factor stimulusGO:00713631970.195
epithelium migrationGO:0090132630.193
locomotory behaviorGO:00076261950.190
exocrine system developmentGO:0035272450.188
positive regulation of sequence specific dna binding transcription factor activityGO:0051091680.187
regulation of rna polymerase ii transcriptional preinitiation complex assemblyGO:004589820.186
regulation of lipid catabolic processGO:0050994150.186
Human
regulation of blood pressureGO:0008217930.184
regulation of apoptotic signaling pathwayGO:20012331970.182
negative regulation of nervous system developmentGO:00519611560.181
negative regulation of phosphate metabolic processGO:00459361840.180
Mouse
regulation of sequence specific dna binding transcription factor activityGO:00510901060.180
morphogenesis of a branching structureGO:00017632030.179
nuclear transportGO:00511691390.178
nucleoside catabolic processGO:00091642060.178
regulation of ras protein signal transductionGO:00465781140.177
fat cell differentiationGO:00454441600.176
negative regulation of epithelial cell proliferationGO:0050680640.175
guanosine containing compound metabolic processGO:19010681440.174
regulation of secretionGO:00510462740.173
Human Mouse Rat
asymmetric stem cell divisionGO:009872230.173
Fly
organic cyclic compound catabolic processGO:19013612950.172
positive regulation of insulin secretionGO:0032024260.172
Mouse
heart contractionGO:0060047930.171
cellular carbohydrate metabolic processGO:00442621190.169
Human
ossificationGO:00015032160.168
cellular response to cytokine stimulusGO:00713451890.165
osteoclast differentiationGO:0030316620.164
glycosyl compound catabolic processGO:19016582060.164
regulation of nucleoside metabolic processGO:00091181300.161
commissural neuron axon guidanceGO:007167980.160
rhythmic processGO:00485111740.159
positive regulation of cellular catabolic processGO:00313311480.159
Human
regulation of hydrolase activityGO:00513362460.158
nucleoside triphosphate catabolic processGO:00091432050.155
posttranscriptional regulation of gene expressionGO:00106081550.154
glycerophospholipid biosynthetic processGO:0046474320.152
inner ear morphogenesisGO:00424721010.152
response to insulinGO:00328681000.151
female sex differentiationGO:0046660840.151
body morphogenesisGO:0010171450.151
regulation of embryonic developmentGO:0045995710.150
negative regulation of cellular component organizationGO:00511291940.150
regulation of jnk cascadeGO:0046328620.150
response to peptideGO:19016521360.149
regulation of rho protein signal transductionGO:0035023710.149
retina development in camera type eyeGO:00600411190.149
stress activated mapk cascadeGO:0051403800.148
syncytiotrophoblast cell differentiation involved in labyrinthine layer developmentGO:006071520.147
cell junction organizationGO:0034330770.146
regulation of vesicle mediated transportGO:00606271390.146
positive regulation of jnk cascadeGO:0046330460.145
asymmetric neuroblast divisionGO:005505910.143
lipid biosynthetic processGO:00086101790.143
male germ line stem cell asymmetric divisionGO:004813320.142
Fly
learningGO:0007612980.142
Fly
developmental maturationGO:00217001930.142
proteolysis involved in cellular protein catabolic processGO:00516031470.139
male gamete generationGO:00482322850.139
Fly
regulation of peptidyl serine phosphorylationGO:0033135390.138
regulation of protein processingGO:0070613960.138
regulation of glucan biosynthetic processGO:001096270.138
Human
regulation of wnt signaling pathwayGO:00301111230.137
regulation of cysteine type endopeptidase activity involved in apoptotic processGO:0043281620.137
developmental cell growthGO:0048588840.137
Fly
negative regulation of transferase activityGO:0051348850.136
Mouse
labyrinthine layer developmentGO:0060711490.136
lymphocyte proliferationGO:00466511640.135
Mouse
synapse assemblyGO:0007416560.132
metal ion homeostasisGO:00550651890.132
hippocampus developmentGO:0021766520.132
insulin like growth factor receptor signaling pathwayGO:0048009210.132
Human
gland developmentGO:00487323300.131
regulation of leukocyte proliferationGO:00706631210.130
Mouse
cerebellum morphogenesisGO:0021587420.129
gtp metabolic processGO:00460391440.129
ureteric bud developmentGO:0001657940.129
homophilic cell adhesion via plasma membrane adhesion moleculesGO:0007156180.129
phosphatidylinositol biosynthetic processGO:0006661150.129
negative regulation of protein serine threonine kinase activityGO:0071901490.128
carbohydrate derivative catabolic processGO:19011362310.128
adult behaviorGO:00305341350.127
actomyosin structure organizationGO:0031032560.127
regulation of bmp signaling pathwayGO:0030510600.126
plasma membrane long chain fatty acid transportGO:001591110.126
regulation of peptide hormone secretionGO:0090276750.125
Human Mouse Rat
rho protein signal transductionGO:0007266320.124
regulation of protein targetingGO:1903533610.124
positive regulation of cell projection organizationGO:0031346950.123
regulation of canonical wnt signaling pathwayGO:0060828820.123
negative regulation of intracellular signal transductionGO:19025321670.122
regulation of epithelial cell proliferationGO:00506781410.122
peptidyl tyrosine modificationGO:00182121450.122
regulation of protein localization to nucleusGO:1900180600.121
positive regulation of stress activated mapk cascadeGO:0032874480.121
purine nucleotide catabolic processGO:00061952110.120
response to nutrient levelsGO:00316671090.119
Fly
negative regulation of prostatic bud formationGO:006068640.118
immune effector processGO:00022523210.117
regulation of angiogenesisGO:0045765810.117
response to extracellular stimulusGO:00099911270.116
Fly
regulation of cellular response to growth factor stimulusGO:0090287820.116
cellular macromolecule catabolic processGO:00442652060.116
response to metal ionGO:0010038470.116
regulation of protein maturationGO:1903317960.116
neuron migrationGO:00017641220.116
cerebral cortex developmentGO:0021987860.115
skin developmentGO:00435882200.115
cartilage development involved in endochondral bone morphogenesisGO:0060351240.114
regulation of feeding behaviorGO:006025930.113
defecationGO:003042110.113
regulation of glucose transportGO:0010827320.112
Human
regulation of generation of precursor metabolites and energyGO:0043467380.112
Human
ear developmentGO:00435832000.112
neuron deathGO:00709971540.112
regulation of synaptic plasticityGO:0048167870.111
protein catabolic processGO:00301632210.111
dna metabolic processGO:00062593030.111
regulation of nucleocytoplasmic transportGO:0046822730.111
regulation of gliogenesisGO:0014013500.111
wnt signaling pathway planar cell polarity pathwayGO:0060071270.110
epithelial cell proliferationGO:00506731740.110
regulation of cysteine type endopeptidase activityGO:2000116650.110
ovulationGO:0030728150.110
hexose metabolic processGO:0019318980.109
Human
negative regulation of extrinsic apoptotic signaling pathwayGO:2001237450.109
negative regulation of phosphorus metabolic processGO:00105631840.109
Mouse
germline stem cell asymmetric divisionGO:009872820.109
Fly
glycogen metabolic processGO:0005977320.109
Human
nitrogen compound transportGO:00717052710.109
Human Mouse Rat
muscle cell proliferationGO:0033002520.108
organophosphate catabolic processGO:00464342320.107
cellular response to acid chemicalGO:0071229680.106
adult locomotory behaviorGO:0008344910.106
heterocycle catabolic processGO:00467002800.106
cellular response to amino acid stimulusGO:0071230290.106
negative regulation of cell cycleGO:00457861230.105
pallium developmentGO:00215431200.105
epidermis developmentGO:00085441870.105
central nervous system neuron differentiationGO:00219531620.105
ephrin receptor signaling pathwayGO:0048013200.105
positive regulation of cell activationGO:00508671580.104
Mouse
cellular response to hormone stimulusGO:00328701500.104
nucleotide metabolic processGO:00091173320.103
embryonic epithelial tube formationGO:00018381300.103
activation of janus kinase activityGO:004297620.102
oligodendrocyte differentiationGO:0048709530.101
protein maturationGO:00516041760.101
heart processGO:0003015940.101
notochord cell developmentGO:006003510.100
b cell activationGO:00421131610.100
Mouse
epithelial cell developmentGO:00020641590.100
cell matrix adhesionGO:0007160680.100
oogenesisGO:0048477560.099
Fly
nucleobase containing small molecule metabolic processGO:00550863520.098
negative regulation of neuron differentiationGO:00456651010.097
response to radiationGO:00093141650.097
gtp catabolic processGO:00061841430.096
axis elongation involved in somitogenesisGO:009024540.096
platelet activationGO:0030168400.096
organonitrogen compound catabolic processGO:19015652640.096
regulation of ion transmembrane transportGO:00347651190.095
cellular glucan metabolic processGO:0006073320.095
Human
regulation of glial cell differentiationGO:0045685410.095
purine containing compound metabolic processGO:00725213110.094
primary neural tube formationGO:0014020950.094
gastrulationGO:00073691160.094
cellular component assembly involved in morphogenesisGO:00109271390.094
protein autophosphorylationGO:0046777610.093
leukocyte apoptotic processGO:0071887710.093
Mouse
regulation of protein secretionGO:0050708820.092
neuron projection regenerationGO:0031102140.092
purine ribonucleotide catabolic processGO:00091542080.092
regulation of endothelial cell migrationGO:0010594220.092
regulation of neuron projection regenerationGO:007057070.092
leukocyte differentiationGO:00025213420.092
progesterone secretionGO:004270110.092
coagulationGO:0050817780.092
cellular amine metabolic processGO:0044106440.091
cellular response to carbohydrate stimulusGO:0071322500.091
negative regulation of proteolysisGO:0045861740.091
positive regulation of fatty acid oxidationGO:004632140.091
Human
positive regulation of fatty acid beta oxidationGO:003200010.090
Human
regulation of catenin import into nucleusGO:003541250.090
positive regulation of glucose transportGO:0010828160.090
Human
sensory perceptionGO:00076002450.089
mesoderm developmentGO:00074981000.089
limb developmentGO:00601731660.089
amide transportGO:00428861380.088
Human Mouse Rat
glial cell developmentGO:0021782540.087
central nervous system neuron developmentGO:0021954670.087
cation homeostasisGO:00550802120.087
homotypic cell cell adhesionGO:0034109280.087
epithelial tube morphogenesisGO:00605623030.087
regulation of cartilage developmentGO:0061035440.086
nucleocytoplasmic transportGO:00069131390.086
positive regulation of peptide secretionGO:0002793330.086
Mouse Rat
positive regulation of cell cycleGO:0045787920.086
neuron projection extensionGO:1990138640.086
negative regulation of fatty acid transportGO:200019210.085
negative regulation of mesenchymal cell proliferationGO:007220130.085
positive regulation of secretionGO:00510471300.085
Mouse Rat
cerebellum vasculature morphogenesisGO:006130110.085
ear morphogenesisGO:00424711180.084
transforming growth factor beta receptor signaling pathwayGO:0007179710.084
regulation of lymphocyte activationGO:00512492400.084
Mouse
fasciculation of motor neuron axonGO:009715620.084
regulation of b cell proliferationGO:0030888390.084
Mouse
peptide hormone secretionGO:00300721090.084
Human Mouse Rat
gonad developmentGO:00084061410.084
regulation of cell sizeGO:0008361720.083
layer formation in cerebral cortexGO:0021819130.083
regulation of ras gtpase activityGO:0032318880.083
positive regulation of protein transportGO:0051222930.083
regulation of cellular response to insulin stimulusGO:1900076300.083
Human Rat
ribonucleoside catabolic processGO:00424542060.082
glucose homeostasisGO:00425931280.082
positive regulation of leukocyte proliferationGO:0070665730.082
Mouse
organelle fissionGO:00482851700.082
positive regulation of peptidyl serine phosphorylationGO:0033138250.082
negative regulation of protein metabolic processGO:00512482820.082
carbohydrate derivative biosynthetic processGO:19011371830.081
retina morphogenesis in camera type eyeGO:0060042450.081
regulation of tight junction assemblyGO:200081020.081
heart trabecula formationGO:0060347140.081
developmental growth involved in morphogenesisGO:00605601380.081
positive regulation of lymphocyte proliferationGO:0050671700.081
Mouse
regulation of striated muscle cell differentiationGO:0051153810.081
positive regulation of transmembrane receptor protein serine threonine kinase signaling pathwayGO:0090100430.080
myotube cell developmentGO:0014904600.080
embryonic organ morphogenesisGO:00485622760.080
morphogenesis of a branching epitheliumGO:00611381930.079
negative regulation of protein phosphorylationGO:00019331260.079
cell maturationGO:00484691270.078
modification dependent macromolecule catabolic processGO:00436321330.078
establishment of planar polarity involved in neural tube closureGO:0090177150.078
mammary gland epithelium developmentGO:0061180650.078
phosphatidylinositol phosphorylationGO:0046854230.078
stress activated protein kinase signaling cascadeGO:0031098810.078
bmp signaling pathwayGO:0030509930.077
purine ribonucleotide metabolic processGO:00091502900.077
striated muscle cell proliferationGO:0014855390.076
regulation of jun kinase activityGO:0043506400.076
hindbrain radial glia guided cell migrationGO:0021932120.075
photoreceptor cell developmentGO:0042461400.075
metencephalon developmentGO:0022037890.075
regulation of extrinsic apoptotic signaling pathwayGO:2001236770.075
fatty acid transmembrane transportGO:190200110.075
defense response to other organismGO:00985421970.074
endocrine system developmentGO:0035270980.074
protein kinase b signalingGO:0043491740.074
purine ribonucleoside triphosphate metabolic processGO:00092052200.073
central nervous system projection neuron axonogenesisGO:0021952210.073
nucleotide catabolic processGO:00091662170.073
dendritic spine organizationGO:0097061260.073
positive regulation of stem cell proliferationGO:2000648590.072
negative regulation of catenin import into nucleusGO:003541420.072
negative regulation of protein maturationGO:1903318790.072
cerebellum developmentGO:0021549770.072
response to acid chemicalGO:00011011110.071
negative regulation of cellular amino acid metabolic processGO:004576300.071
nucleoside phosphate catabolic processGO:19012922220.071
positive regulation of rna polymerase ii transcriptional preinitiation complex assemblyGO:004589920.071
positive regulation of long term neuronal synaptic plasticityGO:004817030.071
chemotaxisGO:00069352470.071
lipid localizationGO:00108761260.070
aromatic compound catabolic processGO:00194392860.070
embryonic camera type eye developmentGO:0031076360.070
oocyte maturationGO:0001556180.070
cell fate specificationGO:0001708720.070
positive regulation of jun kinase activityGO:0043507300.070
positive regulation of b cell proliferationGO:0030890240.070
Mouse
forebrain developmentGO:00309003020.069
multicellular organismal agingGO:0010259240.069
Fly
development of primary female sexual characteristicsGO:0046545730.069

Irs1 disease predictions

Disease predictions are made from cross-annotation of human disease genes to the identified functional analogs in mouse and predicted with the mouse functional network.

DiseaseDO term IDSizeProbabilityFunc Analog Org
diabetes mellitusDOID:935100.156
Human
type 2 diabetes mellitusDOID:935200.156
Human
disease of metabolismDOID:001466700.156
Human
carbohydrate metabolism diseaseDOID:005001300.156
Human
glucose metabolism diseaseDOID:419400.156
Human
acquired metabolic diseaseDOID:006015800.156
Human