IMP: Integrative Multi-species Prediction

Mus musculus

18 known processes

Eif3b

eukaryotic translation initiation factor 3, subunit B

(Aliases: PRT1,AL033369,AW208965,EIF3-P116,AL033316,D5Wsu45e,AL033334,EIF3-ETA,EIF3-P110,Eif3s9)

Ensembl: ENSMUSG00000056076
Entrez: 27979
UniProtKB: Q8JZQ9

Process Predictions
Disease Predictions

Eif3b biological process predictions

Show only novel predictionsHighlight processes of functional analogs

Filter by process size:

Biological process	GO term ID	Process size	Probability	Func Analog Org
translational initiation	GO:0006413	24	0.999
cytoplasmic translational initiation	GO:0002183	3	0.980
translation	GO:0006412	93	0.961
regulation of translation	GO:0006417	71	0.734	Human
dna metabolic process	GO:0006259	303	0.389
nls bearing protein import into nucleus	GO:0006607	2	0.372
mitotic cell cycle	GO:0000278	195	0.371
rna processing	GO:0006396	105	0.243
protein modification by small protein conjugation or removal	GO:0070647	207	0.178
chromatin organization	GO:0006325	206	0.150
cellular amine metabolic process	GO:0044106	44	0.147
regulation of translational initiation	GO:0006446	15	0.143	Human
protein localization to nucleus	GO:0034504	121	0.133
cellular response to dna damage stimulus	GO:0006974	207	0.102
posttranscriptional regulation of gene expression	GO:0010608	155	0.100	Human
aromatic compound catabolic process	GO:0019439	286	0.095
amine metabolic process	GO:0009308	45	0.084
microtubule cytoskeleton organization	GO:0000226	157	0.084
positive regulation of cell death	GO:0010942	224	0.067
microtubule based process	GO:0007017	236	0.062
nuclear division	GO:0000280	158	0.061
regulation of cell cycle	GO:0051726	281	0.061
rrna processing	GO:0006364	10	0.060
dna repair	GO:0006281	107	0.056
spindle organization	GO:0007051	28	0.055
macromolecule catabolic process	GO:0009057	281	0.055
oocyte anterior posterior axis specification	GO:0007314	2	0.054
protein dna complex subunit organization	GO:0071824	28	0.054
regulation of intracellular transport	GO:0032386	159	0.054
methylation	GO:0032259	134	0.053
positive regulation of protein modification process	GO:0031401	299	0.049
purine nucleoside catabolic process	GO:0006152	205	0.049
protein modification by small protein conjugation	GO:0032446	187	0.049
nuclear transport	GO:0051169	139	0.048
stem cell differentiation	GO:0048863	268	0.047	Zebrafish
placenta development	GO:0001890	140	0.046
macromolecule methylation	GO:0043414	120	0.046
positive regulation of rna polymerase ii transcriptional preinitiation complex assembly	GO:0045899	2	0.045
regulation of protein localization	GO:0032880	231	0.045
response to nutrient levels	GO:0031667	109	0.045
stem cell development	GO:0048864	219	0.044	Zebrafish
purine ribonucleoside triphosphate catabolic process	GO:0009207	199	0.044
purine ribonucleoside triphosphate metabolic process	GO:0009205	220	0.043
glycosyl compound metabolic process	GO:1901657	246	0.043
cellular response to extracellular stimulus	GO:0031668	81	0.043
organelle fission	GO:0048285	170	0.043
cellular response to nutrient levels	GO:0031669	64	0.041
trna modification	GO:0006400	9	0.041
ribosomal small subunit biogenesis	GO:0042274	4	0.041
protein catabolic process	GO:0030163	221	0.039
response to temperature stimulus	GO:0009266	55	0.038
mitotic cell cycle process	GO:1903047	159	0.038
cellular response to lipid	GO:0071396	145	0.038
protein desumoylation	GO:0016926	2	0.037
spermatogenesis	GO:0007283	284	0.037
purine nucleoside triphosphate catabolic process	GO:0009146	203	0.036
ribonucleoside metabolic process	GO:0009119	245	0.035
gonad development	GO:0008406	141	0.035
positive regulation of apoptotic process	GO:0043065	217	0.035
cellular amino acid metabolic process	GO:0006520	103	0.034
organic cyclic compound catabolic process	GO:1901361	295	0.034
response to heat	GO:0009408	27	0.033
regulation of cell growth	GO:0001558	91	0.033
attachment of spindle microtubules to kinetochore	GO:0008608	4	0.032
female gamete generation	GO:0007292	74	0.032
male gamete generation	GO:0048232	285	0.032
rna polymerase ii transcriptional preinitiation complex assembly	GO:0051123	3	0.032
mitotic spindle organization	GO:0007052	10	0.031
regulation of protein import into nucleus	GO:0042306	52	0.031
nucleobase containing small molecule metabolic process	GO:0055086	352	0.030
regulation of response to alcohol	GO:1901419	2	0.030
establishment of protein localization to organelle	GO:0072594	118	0.030
purine ribonucleoside metabolic process	GO:0046128	241	0.030
positive regulation of programmed cell death	GO:0043068	218	0.030
cellularization	GO:0007349	1	0.030
purine containing compound metabolic process	GO:0072521	311	0.029
spermatid differentiation	GO:0048515	115	0.029
protein ubiquitination	GO:0016567	171	0.029
regulation of cytoplasmic transport	GO:1903649	112	0.028
nucleoside triphosphate metabolic process	GO:0009141	230	0.028
ribonucleotide catabolic process	GO:0009261	208	0.027
positive regulation of intracellular transport	GO:0032388	70	0.027
endoplasmic reticulum unfolded protein response	GO:0030968	19	0.027
nuclear export	GO:0051168	34	0.027
molting cycle	GO:0042303	90	0.027
ribose phosphate metabolic process	GO:0019693	291	0.027
response to acid chemical	GO:0001101	111	0.027
positive regulation of protein localization to nucleus	GO:1900182	30	0.027
regulation of establishment of protein localization	GO:0070201	181	0.025
nucleoside triphosphate catabolic process	GO:0009143	205	0.025
dna modification	GO:0006304	50	0.025
mitotic nuclear division	GO:0007067	48	0.025
dna packaging	GO:0006323	30	0.025
endonucleolytic cleavage involved in rrna processing	GO:0000478	1	0.025
carbohydrate metabolic process	GO:0005975	230	0.024
cellular homeostasis	GO:0019725	240	0.024
organophosphate catabolic process	GO:0046434	232	0.024
organonitrogen compound catabolic process	GO:1901565	264	0.024
response to endoplasmic reticulum stress	GO:0034976	53	0.024
dephosphorylation	GO:0016311	129	0.023
substrate adhesion dependent cell spreading	GO:0034446	30	0.023
glycosyl compound catabolic process	GO:1901658	206	0.023
cellular response to organic cyclic compound	GO:0071407	87	0.023
trna wobble uridine modification	GO:0002098	2	0.023
purine ribonucleoside catabolic process	GO:0046130	205	0.023
stem cell maintenance	GO:0019827	130	0.023
nuclear import	GO:0051170	95	0.023
wnt signaling pathway	GO:0016055	188	0.023
regulation of mitotic cell cycle phase transition	GO:1901990	73	0.023
skin development	GO:0043588	220	0.022
purine nucleotide catabolic process	GO:0006195	211	0.022
divalent inorganic cation homeostasis	GO:0072507	138	0.022
development of primary sexual characteristics	GO:0045137	143	0.022
proteolysis involved in cellular protein catabolic process	GO:0051603	147	0.021
germ cell development	GO:0007281	185	0.021
regulation of ran gtpase activity	GO:0032316	3	0.021
positive regulation of translation	GO:0045727	19	0.021
regulation of cellular amine metabolic process	GO:0033238	20	0.021
protein modification by small protein removal	GO:0070646	21	0.021
small gtpase mediated signal transduction	GO:0007264	97	0.021
cellular protein complex assembly	GO:0043623	116	0.021
blastocyst development	GO:0001824	80	0.020
single organism nuclear import	GO:1902593	95	0.020
vitamin d receptor signaling pathway	GO:0070561	2	0.020
maintenance of location	GO:0051235	89	0.020	Worm
maturation of 5 8s rrna from tricistronic rrna transcript ssu rrna 5 8s rrna lsu rrna	GO:0000466	1	0.020
positive regulation of cellular amine metabolic process	GO:0033240	5	0.020
purine containing compound catabolic process	GO:0072523	213	0.019
cellular macromolecule catabolic process	GO:0044265	206	0.019
positive regulation of transcription initiation from rna polymerase ii promoter	GO:0060261	5	0.019
organonitrogen compound biosynthetic process	GO:1901566	192	0.019
nucleoside monophosphate metabolic process	GO:0009123	85	0.019
nucleocytoplasmic transport	GO:0006913	139	0.019
glucose homeostasis	GO:0042593	128	0.019
ribonucleoside monophosphate catabolic process	GO:0009158	57	0.018
regulation of mitotic cell cycle	GO:0007346	126	0.018
intracellular protein transport	GO:0006886	204	0.018
epithelial tube morphogenesis	GO:0060562	303	0.018
protein localization to organelle	GO:0033365	185	0.017
polyamine biosynthetic process	GO:0006596	2	0.017
heterocycle catabolic process	GO:0046700	280	0.017
negative regulation of protein metabolic process	GO:0051248	282	0.017
cellular nitrogen compound catabolic process	GO:0044270	280	0.017
ncrna processing	GO:0034470	26	0.017
positive regulation of intracellular protein transport	GO:0090316	42	0.017
pole plasm assembly	GO:0007315	2	0.016
peptidyl amino acid modification	GO:0018193	336	0.016
dna dealkylation	GO:0035510	11	0.016
regulation of intracellular protein transport	GO:0033157	82	0.016
chromatin modification	GO:0016568	187	0.016
aggresome assembly	GO:0070842	2	0.016
nucleoside phosphate catabolic process	GO:1901292	222	0.016
transmembrane transport	GO:0055085	412	0.016
embryonic placenta development	GO:0001892	98	0.016
maturation of lsu rrna from tricistronic rrna transcript ssu rrna 5 8s rrna lsu rrna	GO:0000463	1	0.016
cellular response to external stimulus	GO:0071496	88	0.016
response to unfolded protein	GO:0006986	21	0.016
nucleotide catabolic process	GO:0009166	217	0.016
dna templated transcriptional preinitiation complex assembly	GO:0070897	4	0.016
epidermis development	GO:0008544	187	0.016
regulation of protein catabolic process	GO:0042176	108	0.016
atp catabolic process	GO:0006200	55	0.016
ribonucleoside catabolic process	GO:0042454	206	0.016
response to light stimulus	GO:0009416	135	0.016
negative regulation of protein phosphorylation	GO:0001933	126	0.016
purine nucleoside metabolic process	GO:0042278	241	0.016
purine nucleoside monophosphate metabolic process	GO:0009126	81	0.016
regulation of cell motility	GO:2000145	236	0.016
regulation of carbohydrate biosynthetic process	GO:0043255	40	0.016
regulation of cell migration	GO:0030334	219	0.015
multicellular organismal signaling	GO:0035637	91	0.015
purine ribonucleoside monophosphate catabolic process	GO:0009169	57	0.015
carbohydrate homeostasis	GO:0033500	128	0.015
gluconeogenesis	GO:0006094	39	0.015
ribonucleoside triphosphate metabolic process	GO:0009199	220	0.015
cellular biogenic amine metabolic process	GO:0006576	28	0.015
positive regulation of cellular amino acid metabolic process	GO:0045764	3	0.015
developmental maturation	GO:0021700	193	0.015
positive regulation of protein serine threonine kinase activity	GO:0071902	106	0.015
nucleoside phosphate metabolic process	GO:0006753	338	0.014
regulation of defense response	GO:0031347	233	0.014
cellular ketone metabolic process	GO:0042180	84	0.014
negative regulation of cell cycle	GO:0045786	123	0.014
immune effector process	GO:0002252	321	0.014
cellular protein catabolic process	GO:0044257	155	0.014
dna conformation change	GO:0071103	37	0.014
positive regulation of defense response	GO:0031349	124	0.014
amino acid activation	GO:0043038	1	0.014
positive regulation of protein phosphorylation	GO:0001934	242	0.013
leukocyte differentiation	GO:0002521	342	0.013
cell adhesion	GO:0007155	329	0.013
ribonucleotide metabolic process	GO:0009259	291	0.013
protein maturation	GO:0051604	176	0.013
regulation of nucleocytoplasmic transport	GO:0046822	73	0.013
regulation of protein transport	GO:0051223	163	0.013
histone modification	GO:0016570	159	0.013
cellular carbohydrate metabolic process	GO:0044262	119	0.013
multicellular organismal aging	GO:0010259	24	0.013	Worm
cytoplasmic transport	GO:0016482	234	0.013
protein processing	GO:0016485	163	0.013
nucleoside metabolic process	GO:0009116	246	0.013
oocyte construction	GO:0007308	2	0.013
purine ribonucleoside monophosphate metabolic process	GO:0009167	80	0.013
meiotic nuclear division	GO:0007126	115	0.013
purine ribonucleotide catabolic process	GO:0009154	208	0.013
carbohydrate derivative biosynthetic process	GO:1901137	183	0.013
maturation of 5 8s rrna	GO:0000460	1	0.013
t cell proliferation	GO:0042098	120	0.012
metaphase plate congression	GO:0051310	2	0.012
regulation of cell activation	GO:0050865	289	0.012
carbohydrate biosynthetic process	GO:0016051	74	0.012
skeletal system development	GO:0001501	356	0.012
mrna splicing via spliceosome	GO:0000398	43	0.012
regulation of transmembrane transport	GO:0034762	128	0.012
protein import	GO:0017038	101	0.012
regulation of substrate adhesion dependent cell spreading	GO:1900024	12	0.012
leukocyte proliferation	GO:0070661	172	0.012
regulation of mrna metabolic process	GO:1903311	43	0.012
proteasomal protein catabolic process	GO:0010498	98	0.012
connective tissue development	GO:0061448	179	0.011
lymphocyte proliferation	GO:0046651	164	0.011
cleavage involved in rrna processing	GO:0000469	1	0.011
regulation of cytokine production	GO:0001817	266	0.011
modification dependent macromolecule catabolic process	GO:0043632	133	0.011
regulation of kinase activity	GO:0043549	249	0.011
multi multicellular organism process	GO:0044706	109	0.011
negative regulation of intracellular signal transduction	GO:1902532	167	0.011
regulation of cellular ketone metabolic process	GO:0010565	66	0.011
sensory organ morphogenesis	GO:0090596	242	0.011
regulation of cell substrate adhesion	GO:0010810	73	0.011
positive regulation of transcription elongation from rna polymerase ii promoter	GO:0032968	2	0.011
response to organic cyclic compound	GO:0014070	198	0.011
rhythmic process	GO:0048511	174	0.011
cytokine production	GO:0001816	319	0.011
leukocyte apoptotic process	GO:0071887	71	0.010
ribosome biogenesis	GO:0042254	20	0.010
protein targeting	GO:0006605	143	0.010
regulation of wnt signaling pathway	GO:0030111	123	0.010
circadian regulation of gene expression	GO:0032922	48	0.010
transmission of nerve impulse	GO:0019226	76	0.010
regulation of rna polymerase ii transcriptional preinitiation complex assembly	GO:0045898	2	0.010
peptide metabolic process	GO:0006518	46	0.010
nucleoside monophosphate catabolic process	GO:0009125	59	0.010
regulation of ion transmembrane transport	GO:0034765	119	0.010
regulation of protein localization to nucleus	GO:1900180	60	0.010

Eif3b disease predictions

Disease predictions are made from cross-annotation of human disease genes to the identified functional analogs in mouse and predicted with the mouse functional network.

Disease	DO term ID	Probability
nervous system disease	DOID:863	0.794
disease of anatomical entity	DOID:7	0.794
central nervous system disease	DOID:331	0.298
neurodegenerative disease	DOID:1289	0.254
neuropathy	DOID:870	0.071
neuromuscular disease	DOID:440	0.045
charcot marie tooth disease	DOID:10595	0.020
sensory system disease	DOID:0050155	0.018
retinal degeneration	DOID:8466	0.018
eye and adnexa disease	DOID:1492	0.018
retinal disease	DOID:5679	0.018
eye disease	DOID:5614	0.018
parkinson s disease	DOID:14330	0.012
synucleinopathy	DOID:0050890	0.012

Loading network...

Network Filters

Minimum relationship confidence:

Maximum number of genes:

Highlight known relationships in gold.

Graphical Options

Adjust edge length:

Adjust node size:

Fixed layout

Black background

Low confidence color:

Med confidence color:

High confidence color:

Hide the legend in the network