IMP: Integrative Multi-species Prediction

Mus musculus

26 known processes

Gprc6a

G protein-coupled receptor, family C, group 6, member A

(Aliases: MGC124360)

Entrez: 210198
Ensembl: ENSMUSG00000019905
UniProtKB: Q8K4Z6

Process Predictions
Disease Predictions

Gprc6a biological process predictions

Show only novel predictionsHighlight processes of functional analogs

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Biological process	GO term ID	Process size	Probability	Func Analog Org
type b pancreatic cell proliferation	GO:0044342	10	0.265
regulation of hormone secretion	GO:0046883	88	0.258
positive regulation of hormone secretion	GO:0046887	38	0.218
nitrogen compound transport	GO:0071705	271	0.181
hormone secretion	GO:0046879	128	0.169
insulin secretion	GO:0030073	89	0.152
regulation of secretion by cell	GO:1903530	249	0.144
positive regulation of secretion by cell	GO:1903532	114	0.142
peptide transport	GO:0015833	133	0.138
regulation of peptide secretion	GO:0002791	77	0.137
peptide secretion	GO:0002790	114	0.135
blood vessel morphogenesis	GO:0048514	285	0.126
response to peptide	GO:1901652	136	0.119
response to insulin	GO:0032868	100	0.118
regulation of peptide hormone secretion	GO:0090276	75	0.115
response to peptide hormone	GO:0043434	127	0.112
carbohydrate derivative biosynthetic process	GO:1901137	183	0.111
regulation of peptide transport	GO:0090087	91	0.108
cellular response to hormone stimulus	GO:0032870	150	0.105
positive regulation of peptide secretion	GO:0002793	33	0.103
cellular response to organonitrogen compound	GO:0071417	145	0.099
peptide hormone secretion	GO:0030072	109	0.097
cellular response to peptide hormone stimulus	GO:0071375	92	0.095
response to testosterone	GO:0033574	3	0.094
regulation of ion transport	GO:0043269	215	0.094	Mouse
regulation of secretion	GO:0051046	274	0.094
ion transmembrane transport	GO:0034220	361	0.092
nucleotide metabolic process	GO:0009117	332	0.089	Mouse
negative regulation of vasculature development	GO:1901343	26	0.084
transmembrane transport	GO:0055085	412	0.082
positive regulation of peptide hormone secretion	GO:0090277	31	0.079
cellular response to peptide	GO:1901653	92	0.075
positive regulation of secretion	GO:0051047	130	0.075
cellular response to insulin stimulus	GO:0032869	78	0.074
cellular homeostasis	GO:0019725	240	0.073
cation homeostasis	GO:0055080	212	0.067
negative regulation of angiogenesis	GO:0016525	25	0.066
sequestering of metal ion	GO:0051238	19	0.064
positive regulation of insulin secretion	GO:0032024	26	0.063
response to organonitrogen compound	GO:0010243	246	0.062
negative regulation of blood vessel morphogenesis	GO:2000181	25	0.061
sequestering of calcium ion	GO:0051208	18	0.056
regulation of hormone levels	GO:0010817	211	0.056
cellular chemical homeostasis	GO:0055082	215	0.055
myeloid leukocyte differentiation	GO:0002573	119	0.055
anion transport	GO:0006820	177	0.053
purine containing compound metabolic process	GO:0072521	311	0.052	Mouse
angiogenesis	GO:0001525	201	0.051
positive regulation of thymocyte migration	GO:2000412	2	0.051
multicellular organismal signaling	GO:0035637	91	0.050
immune response regulating signaling pathway	GO:0002764	125	0.050
metal ion homeostasis	GO:0055065	189	0.049
positive regulation of camp mediated signaling	GO:0043950	3	0.046
regulation of cellular amine metabolic process	GO:0033238	20	0.046
sensory perception	GO:0007600	245	0.044	Mouse
cellular metal ion homeostasis	GO:0006875	151	0.044
regulation of striated muscle cell differentiation	GO:0051153	81	0.044
muscle fiber development	GO:0048747	76	0.043
cellular lipid catabolic process	GO:0044242	52	0.042
skeletal system development	GO:0001501	356	0.042
amine metabolic process	GO:0009308	45	0.041
purine ribonucleotide metabolic process	GO:0009150	290	0.041	Mouse
cellular nitrogen compound catabolic process	GO:0044270	280	0.040	Mouse
cellular amino acid metabolic process	GO:0006520	103	0.040
nucleoside phosphate metabolic process	GO:0006753	338	0.039	Mouse
response to drug	GO:0042493	75	0.039
leukocyte differentiation	GO:0002521	342	0.038
negative regulation of blood vessel endothelial cell migration	GO:0043537	3	0.038
tissue remodeling	GO:0048771	102	0.038
osteoblast development	GO:0002076	17	0.038
response to vitamin d	GO:0033280	3	0.038
regulation of reactive oxygen species metabolic process	GO:2000377	40	0.037
lipid catabolic process	GO:0016042	69	0.036
neuron apoptotic process	GO:0051402	142	0.036
nucleobase containing small molecule metabolic process	GO:0055086	352	0.036	Mouse
activation of immune response	GO:0002253	138	0.035
ribonucleotide metabolic process	GO:0009259	291	0.035	Mouse
regulation of reactive oxygen species biosynthetic process	GO:1903426	2	0.033
regulation of cell activation	GO:0050865	289	0.033
activation of mapk activity involved in innate immune response	GO:0035419	2	0.032
glucose homeostasis	GO:0042593	128	0.032
cellular ion homeostasis	GO:0006873	165	0.032
transmission of nerve impulse	GO:0019226	76	0.032
negative regulation of endothelial cell migration	GO:0010596	4	0.031
positive regulation of protein modification process	GO:0031401	299	0.031
reactive oxygen species metabolic process	GO:0072593	84	0.031
positive regulation of t cell activation	GO:0050870	101	0.030
immune response activating signal transduction	GO:0002757	116	0.030
carbohydrate homeostasis	GO:0033500	128	0.030
regulation of cellular ketone metabolic process	GO:0010565	66	0.030
regulation of neuron death	GO:1901214	134	0.030
neuron death	GO:0070997	154	0.029
amide transport	GO:0042886	138	0.029
regulation of membrane potential	GO:0042391	192	0.029
calcium ion transport	GO:0006816	159	0.028	Mouse
positive regulation of purine nucleotide metabolic process	GO:1900544	114	0.028	Mouse
inorganic cation transmembrane transport	GO:0098662	207	0.027
regulation of neuron apoptotic process	GO:0043523	122	0.027
muscle cell development	GO:0055001	133	0.027
regulation of cell migration	GO:0030334	219	0.027
cytosolic calcium ion transport	GO:0060401	48	0.027
organonitrogen compound catabolic process	GO:1901565	264	0.026	Mouse
bone remodeling	GO:0046849	53	0.026
positive regulation of protein serine threonine kinase activity	GO:0071902	106	0.026
ossification	GO:0001503	216	0.026
heterocycle catabolic process	GO:0046700	280	0.026	Mouse
cation transmembrane transport	GO:0098655	266	0.025
membrane organization	GO:0061024	245	0.025
striated muscle cell development	GO:0055002	125	0.025
prevention of polyspermy	GO:0060468	4	0.025
calcium ion transmembrane transport	GO:0070588	85	0.025
response to lipopolysaccharide	GO:0032496	128	0.025
dna metabolic process	GO:0006259	303	0.024
carbohydrate derivative catabolic process	GO:1901136	231	0.024	Mouse
response to nutrient levels	GO:0031667	109	0.024
glycosyl compound metabolic process	GO:1901657	246	0.024	Mouse
skeletal muscle fiber development	GO:0048741	58	0.024
lymphocyte proliferation	GO:0046651	164	0.023
lymphocyte differentiation	GO:0030098	242	0.023
regulation of angiogenesis	GO:0045765	81	0.023
regulation of establishment of protein localization	GO:0070201	181	0.023
regulation of protein secretion	GO:0050708	82	0.022
ribose phosphate metabolic process	GO:0019693	291	0.022	Mouse
regulation of vasculature development	GO:1901342	88	0.022
cellular response to organic cyclic compound	GO:0071407	87	0.021
cell aging	GO:0007569	35	0.021
muscle cell differentiation	GO:0042692	261	0.021
regulation of tumor necrosis factor ligand superfamily member 11 production	GO:2000307	1	0.021
nucleoside phosphate catabolic process	GO:1901292	222	0.021	Mouse
regulation of metal ion transport	GO:0010959	106	0.021	Mouse
innate immune response	GO:0045087	157	0.021
positive regulation of nucleotide metabolic process	GO:0045981	114	0.021	Mouse
response to extracellular stimulus	GO:0009991	127	0.021
activation of innate immune response	GO:0002218	56	0.021
ribonucleotide catabolic process	GO:0009261	208	0.021	Mouse
epithelial cell development	GO:0002064	159	0.020
regulation of innate immune response	GO:0045088	91	0.020
cellular response to growth factor stimulus	GO:0071363	197	0.020
circulatory system process	GO:0003013	197	0.020
positive regulation of transferase activity	GO:0051347	167	0.020
carbohydrate metabolic process	GO:0005975	230	0.020
pattern recognition receptor signaling pathway	GO:0002221	47	0.020
regulation of purine nucleotide metabolic process	GO:1900542	169	0.020	Mouse
positive regulation of eosinophil migration	GO:2000418	2	0.020
regulation of eosinophil migration	GO:2000416	2	0.019
negative regulation of neuron apoptotic process	GO:0043524	92	0.019
av node cell to bundle of his cell communication	GO:0086067	2	0.019
exocytosis	GO:0006887	121	0.019
regulation of protein kinase activity	GO:0045859	232	0.019
action potential	GO:0001508	78	0.019
regulation of apoptotic signaling pathway	GO:2001233	197	0.018
blood circulation	GO:0008015	195	0.018
purine ribonucleoside metabolic process	GO:0046128	241	0.018	Mouse
organic hydroxy compound metabolic process	GO:1901615	203	0.018
glycoprotein biosynthetic process	GO:0009101	89	0.018
cofactor metabolic process	GO:0051186	80	0.018
positive regulation of hydrolase activity	GO:0051345	148	0.018	Mouse
sensory perception of chemical stimulus	GO:0007606	51	0.018	Mouse
purine containing compound catabolic process	GO:0072523	213	0.018	Mouse
purine nucleoside metabolic process	GO:0042278	241	0.018	Mouse
positive regulation of map kinase activity	GO:0043406	84	0.017
purine nucleotide metabolic process	GO:0006163	302	0.017	Mouse
response to organic cyclic compound	GO:0014070	198	0.017
extracellular matrix dependent thymocyte migration	GO:0072680	1	0.017
divalent inorganic cation transport	GO:0072511	178	0.017	Mouse
cellular lipid metabolic process	GO:0044255	323	0.017
protein kinase b signaling	GO:0043491	74	0.017
regulation of response to wounding	GO:1903034	189	0.017
antigen processing and presentation	GO:0019882	47	0.017
negative regulation of protein phosphorylation	GO:0001933	126	0.017
leukocyte migration	GO:0050900	124	0.017
spermatogenesis	GO:0007283	284	0.016
germ cell development	GO:0007281	185	0.016
cellular response to nutrient levels	GO:0031669	64	0.016
nucleoside metabolic process	GO:0009116	246	0.016	Mouse
inorganic ion transmembrane transport	GO:0098660	234	0.016
regulation of cellular component biogenesis	GO:0044087	181	0.016
neuronal action potential	GO:0019228	54	0.016
positive regulation of cytokine production	GO:0001819	174	0.016
cytoplasmic transport	GO:0016482	234	0.016
tissue homeostasis	GO:0001894	115	0.016
negative regulation of cell proliferation	GO:0008285	296	0.016
purine ribonucleoside catabolic process	GO:0046130	205	0.016	Mouse
cellular response to dna damage stimulus	GO:0006974	207	0.016
purine nucleotide catabolic process	GO:0006195	211	0.016	Mouse
nucleoside catabolic process	GO:0009164	206	0.016	Mouse
leukocyte activation involved in immune response	GO:0002366	126	0.016
positive regulation of cell death	GO:0010942	224	0.016
positive regulation of lymphocyte activation	GO:0051251	140	0.015
positive regulation of reactive oxygen species metabolic process	GO:2000379	11	0.015
cell chemotaxis	GO:0060326	81	0.015
negative regulation of hormone metabolic process	GO:0032351	4	0.015
regulation of cytokine production	GO:0001817	266	0.015
regulation of cell cycle	GO:0051726	281	0.015
myotube differentiation	GO:0014902	105	0.015
regulation of ion homeostasis	GO:2000021	64	0.015
single organismal cell cell adhesion	GO:0016337	131	0.015
aromatic compound catabolic process	GO:0019439	286	0.015	Mouse
plasma membrane organization	GO:0007009	90	0.015
ear development	GO:0043583	200	0.015
positive regulation of innate immune response	GO:0045089	80	0.015
regulation of lymphocyte activation	GO:0051249	240	0.015
anatomical structure homeostasis	GO:0060249	145	0.015
carboxylic acid transport	GO:0046942	100	0.015
response to starvation	GO:0042594	65	0.015
axon ensheathment	GO:0008366	76	0.015
cyclic nucleotide metabolic process	GO:0009187	59	0.015
t cell differentiation in thymus	GO:0033077	77	0.015
macromolecule catabolic process	GO:0009057	281	0.015
ribonucleoside triphosphate metabolic process	GO:0009199	220	0.015	Mouse
single organism cell adhesion	GO:0098602	156	0.015
synaptic transmission	GO:0007268	329	0.014
cell type specific apoptotic process	GO:0097285	268	0.014
positive regulation of protein secretion	GO:0050714	52	0.014
actin filament based movement	GO:0030048	23	0.014
calcium mediated signaling	GO:0019722	46	0.014
reactive oxygen species biosynthetic process	GO:1903409	8	0.014
skeletal muscle organ development	GO:0060538	163	0.014
mapk cascade	GO:0000165	281	0.014
purine ribonucleoside triphosphate metabolic process	GO:0009205	220	0.014	Mouse
regulation of defense response	GO:0031347	233	0.014
positive regulation of protein kinase activity	GO:0045860	144	0.014
regulation of cellular carbohydrate metabolic process	GO:0010675	75	0.014
regulation of leukocyte proliferation	GO:0070663	121	0.014
glucosamine containing compound metabolic process	GO:1901071	3	0.014
response to monosaccharide	GO:0034284	67	0.014
leukocyte chemotaxis	GO:0030595	69	0.014
ribonucleoside catabolic process	GO:0042454	206	0.014	Mouse
regulation of monocyte chemotaxis	GO:0090025	3	0.014
regulation of neuron differentiation	GO:0045664	281	0.013
transmembrane receptor protein tyrosine kinase signaling pathway	GO:0007169	247	0.013
response to acid chemical	GO:0001101	111	0.013
multi multicellular organism process	GO:0044706	109	0.013
positive regulation of cell migration	GO:0030335	109	0.013
positive regulation of membrane protein ectodomain proteolysis	GO:0051044	3	0.013
regulation of t cell activation	GO:0050863	170	0.013
myeloid leukocyte activation	GO:0002274	83	0.013
inter male aggressive behavior	GO:0002121	3	0.013
striated muscle tissue development	GO:0014706	293	0.013
ribonucleoside metabolic process	GO:0009119	245	0.013	Mouse
regulation of homeostatic process	GO:0032844	182	0.013
glycerolipid metabolic process	GO:0046486	122	0.013
regulation of vesicle mediated transport	GO:0060627	139	0.013
inflammatory response to antigenic stimulus	GO:0002437	30	0.013
visual perception	GO:0007601	52	0.013
myotube cell development	GO:0014904	60	0.012
myelination	GO:0042552	74	0.012
regulation of inflammatory response	GO:0050727	147	0.012
regulation of hydrolase activity	GO:0051336	246	0.012	Mouse
epithelium migration	GO:0090132	63	0.012
positive regulation of synaptic growth at neuromuscular junction	GO:0045887	1	0.012
endomembrane system organization	GO:0010256	147	0.012
adaptive immune response	GO:0002250	155	0.012
wnt signaling pathway	GO:0016055	188	0.012
cellular divalent inorganic cation homeostasis	GO:0072503	127	0.012
synapse organization	GO:0050808	125	0.012
connective tissue development	GO:0061448	179	0.012
heart process	GO:0003015	94	0.012
ribonucleoside triphosphate catabolic process	GO:0009203	199	0.012	Mouse
posttranscriptional regulation of gene expression	GO:0010608	155	0.012
glycosyl compound catabolic process	GO:1901658	206	0.012	Mouse
purine ribonucleotide biosynthetic process	GO:0009152	59	0.012
regulation of map kinase activity	GO:0043405	120	0.012
leukocyte homeostasis	GO:0001776	79	0.012
cellular response to lipid	GO:0071396	145	0.012
pma inducible membrane protein ectodomain proteolysis	GO:0051088	1	0.012
response to radiation	GO:0009314	165	0.012
organophosphate catabolic process	GO:0046434	232	0.012	Mouse
guanosine containing compound metabolic process	GO:1901068	144	0.012
endocytosis	GO:0006897	168	0.012
detection of light stimulus	GO:0009583	25	0.012
b cell activation	GO:0042113	161	0.012
regulation of t cell proliferation	GO:0042129	92	0.012
t cell differentiation	GO:0030217	174	0.012
regulation of cytokine secretion	GO:0050707	61	0.012
t cell activation	GO:0042110	289	0.012
pancreas development	GO:0031016	57	0.012
cyclic nucleotide biosynthetic process	GO:0009190	44	0.012
positive regulation of cell activation	GO:0050867	158	0.012
positive regulation of cytokine biosynthetic process	GO:0042108	40	0.012
regulation of thymocyte migration	GO:2000410	2	0.012
organic acid transport	GO:0015849	101	0.011
organic cyclic compound catabolic process	GO:1901361	295	0.011	Mouse
positive regulation of cell adhesion	GO:0045785	80	0.011
release of sequestered calcium ion into cytosol	GO:0051209	42	0.011
cellular ketone metabolic process	GO:0042180	84	0.011
nucleoside triphosphate catabolic process	GO:0009143	205	0.011	Mouse
regulation of androgen receptor signaling pathway	GO:0060765	3	0.011
ras protein signal transduction	GO:0007265	77	0.011
regulation of blood circulation	GO:1903522	93	0.011
purine ribonucleoside triphosphate catabolic process	GO:0009207	199	0.011	Mouse
regulation of membrane protein ectodomain proteolysis	GO:0051043	3	0.011
positive regulation of inositol phosphate biosynthetic process	GO:0060732	2	0.011
divalent inorganic cation homeostasis	GO:0072507	138	0.011
monosaccharide metabolic process	GO:0005996	106	0.011
positive regulation of cell development	GO:0010720	237	0.011
maintenance of location	GO:0051235	89	0.011
alcohol metabolic process	GO:0006066	116	0.011
phospholipase c activating g protein coupled receptor signaling pathway	GO:0007200	26	0.011
negative regulation of keratinocyte differentiation	GO:0045617	4	0.011
positive regulation of programmed cell death	GO:0043068	218	0.011
positive regulation of cd8 positive alpha beta t cell extravasation	GO:2000451	2	0.011
fibronectin dependent thymocyte migration	GO:0072681	1	0.011
regulation of lymphocyte migration	GO:2000401	14	0.011
midgut development	GO:0007494	4	0.011
negative regulation of cellular protein metabolic process	GO:0032269	247	0.011
positive regulation of protein phosphorylation	GO:0001934	242	0.010
positive regulation of inflammatory response	GO:0050729	47	0.010
regulation of viral transcription	GO:0046782	3	0.010
lymphocyte apoptotic process	GO:0070227	54	0.010
intrinsic apoptotic signaling pathway	GO:0097193	132	0.010
apoptotic signaling pathway	GO:0097190	306	0.010
positive regulation of tumor necrosis factor ligand superfamily member 11 production	GO:2000309	1	0.010
multicellular organism growth	GO:0035264	161	0.010
negative regulation of apoptotic signaling pathway	GO:2001234	104	0.010
sa node cell to atrial cardiac muscle cell signalling	GO:0086018	4	0.010
adult behavior	GO:0030534	135	0.010
cellular response to lipopolysaccharide	GO:0071222	77	0.010
cytokine metabolic process	GO:0042107	71	0.010
negative regulation of cellular component organization	GO:0051129	194	0.010
negative regulation of neuron death	GO:1901215	98	0.010
response to growth factor	GO:0070848	198	0.010
glucose metabolic process	GO:0006006	92	0.010
guanosine containing compound catabolic process	GO:1901069	144	0.010
morphogenesis of a branching epithelium	GO:0061138	193	0.010
cellular response to vitamin	GO:0071295	2	0.010
protein targeting to lysosome	GO:0006622	2	0.010
regulation of cellular response to stress	GO:0080135	159	0.010
regulation of adaptive immune response based on somatic recombination of immune receptors built from immunoglobulin superfamily domains	GO:0002822	87	0.010
negative regulation of muscle cell differentiation	GO:0051148	33	0.010

Gprc6a disease predictions

Disease predictions are made from cross-annotation of human disease genes to the identified functional analogs in mouse and predicted with the mouse functional network.

	Disease	DO term ID	Size	Probability	Func Analog Org
	inherited metabolic disorder	DOID:655	0	0.017
	disease of metabolism	DOID:0014667	0	0.017

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